CN105381019A - Effervescent tablet with internal-fire clearing function and preparation method thereof - Google Patents
Effervescent tablet with internal-fire clearing function and preparation method thereof Download PDFInfo
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- CN105381019A CN105381019A CN201510801255.2A CN201510801255A CN105381019A CN 105381019 A CN105381019 A CN 105381019A CN 201510801255 A CN201510801255 A CN 201510801255A CN 105381019 A CN105381019 A CN 105381019A
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- effervescent tablet
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- 239000007938 effervescent tablet Substances 0.000 title claims abstract description 31
- 238000002360 preparation method Methods 0.000 title claims abstract description 14
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims abstract description 46
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 claims abstract description 30
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims abstract description 28
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims abstract description 28
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims abstract description 24
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims abstract description 24
- 239000001530 fumaric acid Substances 0.000 claims abstract description 15
- 239000000843 powder Substances 0.000 claims abstract description 15
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims abstract description 15
- 239000000284 extract Substances 0.000 claims abstract description 13
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 claims abstract description 12
- 229930003268 Vitamin C Natural products 0.000 claims abstract description 12
- 235000019154 vitamin C Nutrition 0.000 claims abstract description 12
- 239000011718 vitamin C Substances 0.000 claims abstract description 12
- UEDUENGHJMELGK-HYDKPPNVSA-N Stevioside Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@]12C(=C)C[C@@]3(C1)CC[C@@H]1[C@@](C)(CCC[C@]1([C@@H]3CC2)C)C(=O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O UEDUENGHJMELGK-HYDKPPNVSA-N 0.000 claims abstract description 10
- 229940013618 stevioside Drugs 0.000 claims abstract description 10
- OHHNJQXIOPOJSC-UHFFFAOYSA-N stevioside Natural products CC1(CCCC2(C)C3(C)CCC4(CC3(CCC12C)CC4=C)OC5OC(CO)C(O)C(O)C5OC6OC(CO)C(O)C(O)C6O)C(=O)OC7OC(CO)C(O)C(O)C7O OHHNJQXIOPOJSC-UHFFFAOYSA-N 0.000 claims abstract description 10
- 235000019202 steviosides Nutrition 0.000 claims abstract description 10
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims abstract description 8
- 235000013305 food Nutrition 0.000 claims abstract description 8
- 239000008101 lactose Substances 0.000 claims abstract description 8
- UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 claims abstract description 4
- 241000628997 Flos Species 0.000 claims description 38
- 239000008187 granular material Substances 0.000 claims description 25
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 claims description 24
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 22
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 18
- 235000014443 Pyrus communis Nutrition 0.000 claims description 15
- 230000001476 alcoholic effect Effects 0.000 claims description 15
- 206010061218 Inflammation Diseases 0.000 claims description 13
- 230000004054 inflammatory process Effects 0.000 claims description 13
- 229910000030 sodium bicarbonate Inorganic materials 0.000 claims description 12
- 235000017557 sodium bicarbonate Nutrition 0.000 claims description 12
- 238000001035 drying Methods 0.000 claims description 10
- 239000000706 filtrate Substances 0.000 claims description 10
- 235000013399 edible fruits Nutrition 0.000 claims description 7
- 239000012141 concentrate Substances 0.000 claims description 5
- 239000000203 mixture Substances 0.000 claims description 5
- 239000002244 precipitate Substances 0.000 claims description 5
- 238000002156 mixing Methods 0.000 claims description 4
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 claims description 2
- 238000000227 grinding Methods 0.000 claims description 2
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- 238000010298 pulverizing process Methods 0.000 claims 1
- 235000013361 beverage Nutrition 0.000 abstract description 7
- 235000009508 confectionery Nutrition 0.000 abstract description 5
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- 208000015220 Febrile disease Diseases 0.000 abstract description 3
- 239000000796 flavoring agent Substances 0.000 abstract description 3
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- 239000002994 raw material Substances 0.000 abstract description 3
- 230000036039 immunity Effects 0.000 abstract description 2
- 235000019640 taste Nutrition 0.000 abstract description 2
- 238000011282 treatment Methods 0.000 abstract description 2
- 241000723353 Chrysanthemum Species 0.000 abstract 3
- 244000167230 Lonicera japonica Species 0.000 abstract 2
- 235000017617 Lonicera japonica Nutrition 0.000 abstract 2
- 241000287420 Pyrus x nivalis Species 0.000 abstract 2
- 241000555682 Forsythia x intermedia Species 0.000 abstract 1
- 241000245240 Lonicera Species 0.000 abstract 1
- 240000000249 Morus alba Species 0.000 abstract 1
- 235000008708 Morus alba Nutrition 0.000 abstract 1
- 230000004069 differentiation Effects 0.000 abstract 1
- 230000002708 enhancing effect Effects 0.000 abstract 1
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 14
- 230000000694 effects Effects 0.000 description 11
- 239000001569 carbon dioxide Substances 0.000 description 7
- 229910002092 carbon dioxide Inorganic materials 0.000 description 7
- 238000007605 air drying Methods 0.000 description 6
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- 231100000614 poison Toxicity 0.000 description 6
- 239000003440 toxic substance Substances 0.000 description 6
- 102000011759 adducin Human genes 0.000 description 4
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- 239000000314 lubricant Substances 0.000 description 4
- 201000007100 Pharyngitis Diseases 0.000 description 3
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 3
- 239000002253 acid Substances 0.000 description 3
- 239000001768 carboxy methyl cellulose Substances 0.000 description 3
- 239000006071 cream Substances 0.000 description 3
- 206010022000 influenza Diseases 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
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- 210000003800 pharynx Anatomy 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 3
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 3
- 239000001509 sodium citrate Substances 0.000 description 3
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 3
- 239000003826 tablet Substances 0.000 description 3
- 206010018286 Gingival pain Diseases 0.000 description 2
- 206010018291 Gingival swelling Diseases 0.000 description 2
- 206010068319 Oropharyngeal pain Diseases 0.000 description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
- 229930006000 Sucrose Natural products 0.000 description 2
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 2
- GAMYVSCDDLXAQW-AOIWZFSPSA-N Thermopsosid Natural products O(C)c1c(O)ccc(C=2Oc3c(c(O)cc(O[C@H]4[C@H](O)[C@@H](O)[C@H](O)[C@H](CO)O4)c3)C(=O)C=2)c1 GAMYVSCDDLXAQW-AOIWZFSPSA-N 0.000 description 2
- 206010046306 Upper respiratory tract infection Diseases 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 229930003944 flavone Natural products 0.000 description 2
- -1 flavone compound Chemical class 0.000 description 2
- 235000011949 flavones Nutrition 0.000 description 2
- 238000005187 foaming Methods 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
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- 210000004072 lung Anatomy 0.000 description 2
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- 229940093429 polyethylene glycol 6000 Drugs 0.000 description 2
- 230000001835 salubrious effect Effects 0.000 description 2
- UIIMBOGNXHQVGW-UHFFFAOYSA-N sodium;hydron;carbonate Chemical compound [Na+].OC(O)=O UIIMBOGNXHQVGW-UHFFFAOYSA-N 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 239000005720 sucrose Substances 0.000 description 2
- VHBFFQKBGNRLFZ-UHFFFAOYSA-N vitamin p Natural products O1C2=CC=CC=C2C(=O)C=C1C1=CC=CC=C1 VHBFFQKBGNRLFZ-UHFFFAOYSA-N 0.000 description 2
- 241000959626 Calvatia Species 0.000 description 1
- 241000131317 Capitulum Species 0.000 description 1
- 208000005623 Carcinogenesis Diseases 0.000 description 1
- 235000008495 Chrysanthemum leucanthemum Nutrition 0.000 description 1
- 244000192528 Chrysanthemum parthenium Species 0.000 description 1
- 235000000604 Chrysanthemum parthenium Nutrition 0.000 description 1
- 244000189548 Chrysanthemum x morifolium Species 0.000 description 1
- 206010010774 Constipation Diseases 0.000 description 1
- 241000721047 Danaus plexippus Species 0.000 description 1
- 206010018275 Gingival atrophy Diseases 0.000 description 1
- 208000032843 Hemorrhage Diseases 0.000 description 1
- 206010020772 Hypertension Diseases 0.000 description 1
- 206010021135 Hypovitaminosis Diseases 0.000 description 1
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- 235000014676 Phragmites communis Nutrition 0.000 description 1
- 206010037660 Pyrexia Diseases 0.000 description 1
- 206010057190 Respiratory tract infections Diseases 0.000 description 1
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 1
- 239000004141 Sodium laurylsulphate Substances 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
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- 150000007516 brønsted-lowry acids Chemical class 0.000 description 1
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- 238000002474 experimental method Methods 0.000 description 1
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- 235000008384 feverfew Nutrition 0.000 description 1
- 150000002212 flavone derivatives Chemical class 0.000 description 1
- 239000006260 foam Substances 0.000 description 1
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- 235000011087 fumaric acid Nutrition 0.000 description 1
- 201000005562 gingival recession Diseases 0.000 description 1
- 229930182478 glucoside Natural products 0.000 description 1
- 150000008131 glucosides Chemical class 0.000 description 1
- 238000005469 granulation Methods 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/287—Chrysanthemum, e.g. daisy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
- A61K36/355—Lonicera (honeysuckle)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0007—Effervescent
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
Abstract
The invention discloses an effervescent tablet with an internal-fire clearing function. The effervescent tablet is prepared from the following components in percentage by mass: 10-20 percent of snow pear powder, 10-20 percent of lonicera japonica and chrysanthemum mixed extract, 0.1-0.25 percent of vitamin C, 15-25 percent of citric acid, 10-15 percent of sodium bicarbonate, 10.75-37.4 percent of lactose, 3 percent of fumaric acid, 1-2 percent of stevioside, 3 percent of polyvinylpyrrolidone and 0.5-1 percent of food flavor. The invention further discloses a preparation method of the effervescent tablet. According to the traditional Chinese medical theory in Treatise on Febrile Diseases and prescription of powder of lonicera and forsythia and decoction of mulberry and chrysanthemum in the Treatise on Differentiation and Treatment of Epidemic Febrile Disease, the medical and edible raw materials including lonicera japonica, chrysanthemum and snow pear are combined with vitamin C which can be used for enhancing the immunity of human bodies by means of effervescent table preparation method to prepare a food suitable for the rapid pace of modern lives. The effervescent tablet is convenient to carry, can be taken when being brewed, tastes sweet and refreshing, can be easily accepted, and can be used as a common beverage for relieving summer heat in summer.
Description
Technical field
The invention belongs to food manufacture field, be specifically related to a kind of effervescent tablet with function of relieving inflammation or internal heat.
Background technology
Effervescent tablet be with suitable acid, alkali is for disintegrating agent and add a kind of tablet that other raw material makes, drop in water, there is violent chemical reaction in bronsted lowry acids and bases bronsted lowry, produce carbon dioxide, impel a kind of novel troche that tablet disintegrate within the section time is dissolved, national GB/T29602-2013 " solid beverage " is to arrange it for specific type solid beverage.
The traditional Chinese medical science is thought: our daily indication " getting angry " is real attacks lung system for damp with the gas cut of suction, visitor is in the pathological change in throat and oral cavity, it shows as: thirsty, red tongue, have sore throat, gingival swelling and pain etc., tcm therapy, heat-clearing and toxic substances removing should rank first, the cause of disease is only had to remove, heat could move back cool skin, but only have heat clearing away and non-YIN nourishing, though to bring down a fever and the difficulty that swells and ache disappears, therefore the product of removing dampness row Tianjin yin nourishing should be joined, so select the product of medicine-food two-purpose: Flos Lonicerae, Flos Chrysanthemi, pear, the above two heat-clearing and toxic substances removing, the latter's yin nourishing dampness removing, plays the effect that Tianjin is adjusted in heat clearing away altogether.
Summary of the invention
The object of the present invention is to provide a kind of effervescent tablet with function of relieving inflammation or internal heat.
Technical scheme of the present invention is achieved in the following ways:
A kind of effervescent tablet with function of relieving inflammation or internal heat, by mass percentage, comprise pear fruit powder 10 ~ 20%, Flos Lonicerae, Flos Chrysanthemi mixed extract 10 ~ 20%, vitamin C 0.1 ~ 0.25%, citric acid 15 ~ 25%, sodium bicarbonate 10 ~ 15%, lactose 10.75 ~ 37.4%, fumaric acid 3%, stevioside 1 ~ 2%, polyvinylpyrrolidone 3%, essence for food 0.5 ~ 1%.
Present invention also offers above-mentioned having to relieve inflammation or internal heat the preparation method of effervescent tablet of function, its step comprises:
A, decoction and alcohol sedimentation technique prepare Flos Lonicerae, Flos Chrysanthemi powdery mixed extract;
The alcoholic solution of B, citric acid, vitamin C PVP is granulated, the alcoholic solution of sodium bicarbonate, lactose, stevioside PVP is granulated, above granule takes according to quantity, and take Flos Lonicerae, Flos Chrysanthemi mixed extract powder, pear fruit powder, add fumaric acid and essence for food mix homogeneously tabletting, packaging.
Further, in described steps A, Flos Lonicerae, Flos Chrysanthemi add 10 times of water gagings, soak 30min, 100 DEG C of decoctions, decoct twice, each 1 hour, and filtrate merges, and filtrate is concentrated into relative density 1.10 ~ 1.15%, add 95% ethanol precipitate with ethanol, concentrate, drying under reduced pressure powdering.
Further, the alcoholic solution of described PVP is 90% alcoholic solution of the PVP of 3%.
The present invention is theoretical for instructing with traditional Chinese medical science treatise on Febrile Diseases, change and cut out " Lonicerae and Forsythiae Powder " and " SANGJU YIN " compatibility of medicines in a prescription in " Wenbing Tiaobian, Detailed Analysis of Epidemic Warm Diseases ", the Flos Lonicerae of medicine-food two-purpose, Flos Chrysanthemi, pear is selected to be raw material, strengthened the vitamin C of human immunity, the food of a kind of applicable modern fast pace life style of inventing in conjunction with this Modern preparations mode of effervescent tablet.Effervescent tablet of the present invention has easy to carry, and with bubble with drink, taste and sweet mouthfeel is salubrious, and the advantage of taking like a shot, also can be used as the conventional beverage of relieving summer heat summer.
Described Flos Lonicerae is dry flower or the first flower opened of band of vine Radix Ophiopogonis Radix Ophiopogonis, sweet in the mouth, cold in nature, energy heat-clearing and toxic substances removing, be usually used in anemopyretic cold, sore throat etc., Flos Lonicerae is mainly containing compounds such as organic acid, flavone, triterpenes, Flos Lonicerae is the monarch drug of many Chinese medicine preparation, and as loose in YINQIAO Lasiosphaera Seu Calvatia, silver-colored short, bristly hair or beard a kind of reed mentioned in ancient books connects soup, wuwei xiaodu drink etc., and the preparation based on Flos Lonicerae has good effect to flu, influenza, upper respiratory tract infection etc.
Described Flos Chrysanthemi is the dry capitulum of feverfew chrysanthemum, sweet in the mouth, hardship, cold nature, has effect of loose wind heat clearing away, suppressing the hyperactive liver improving eyesight, heat-clearing and toxic substances removing, record according to Compendium of Material Medica: cure mainly head's wind heat, brain osteodynia pain, except unhappy in the heart, Flos Chrysanthemi principle active component is flavone compound.
Described pear, records according to Compendium of Material Medica: can control wind heat, lung moistening, quench, removing toxic substances, modern medicine proves, the dry pharynx that pear occurs acute upper respiratory tract infection patient, pharyngalgia, expectorant are thick, constipation, dark coloured urine all have good effect.
Described vitamin C is a kind of water soluble antioxidant, the integrity of cell and normally carrying out of metabolism can be ensured, promote the removing toxic substances of liver and improve enzymatic activity, hypovitaminosis C, easy gingival atrophy, hemorrhage, there is periodontitis and laryngopharynx swelling and pain, vitamin C is the vitamin that treatment flu, pharyngitis, rhinitis etc. are commonly used.
Described stevioside is a kind of glucosides extracted from the leaf of Folium Stevlae Rebaudianae, as a kind of safe and reliable non-nutritive sweetener, there is high sugariness, feature low in calories, its sugariness is 200-300 times of sucrose, and heat is only 1/300th of sucrose, through experimental results demonstrate, stevioside has no side effect, non-carcinogenesis, and can prophylaxis of hypertension, diabetes, obesity, dental caries etc. is the desirable for sugared sweeting agent of a kind of natural origin.
In described effervescent tablet, effervescent is citric acid and sodium bicarbonate, violent chemical reaction is there is in citric acid and sodium bicarbonate in water, produce carbon dioxide, in certain volume water, citric acid is directly proportional to the generation of the amount of sodium bicarbonate to the carbon dioxide in effervescent tablet, the best aerogenesis of citric acid and sodium bicarbonate than being 0.76:1, but now about aqueous ph value neutrality, mouthfeel is poor, in order to adjust mouthfeel, the ratio of general citric acid and sodium bicarbonate is 0.9 ~ 1.7:1, and pH value is 4.5 ~ 5.0.Carbon dioxide is indispensable composition in soda pop, and the Main Function of carbon dioxide in soda pop strengthens local flavor, can also bring mouthfeel of stopping to people.Amount of carbon dioxide is higher, and effervescent tablet foaming effect Shaoxing opera is strong.But while consideration foaming effect, the sodium citrate produced in the beverage after also will taking into account acid-base reaction, because sodium citrate can make beverage produce offending astringent taste, thus produces important impact to the mouthfeel of beverage, therefore the consumption of citric acid and sodium bicarbonate is also unsuitable too high.Therefore citric acid of the present invention and the sodium bicarbonate consumption in effervescent tablet formula is sodium citrate 15 ~ 25%, sodium bicarbonate 10 ~ 15%, and bubble violent, the persistent period is longer.
Described polyvinylpyrrolidone (PVP) is binding agent, convas tablet binding agent has PVP, sugar liquid, starch slurry, polyvinyl acetate copolymer, sodium carboxymethyl cellulose etc., the present inventor contrasts discovery by experiment, select sugar liquid as binding agent, batching citric acid powder is easily lumpd in granulation process, slow-drying, the dried granule also very easily moisture absorption.Select sodium carboxymethyl cellulose as binding agent, sodium carboxymethyl cellulose is difficult to dissolve at short notice, also easily lumps in pelletization, is difficult to dry, and is unsuitable for large production operation.PVP is as binding agent, and rapidly, product dissolves rapidly for granule prevented from caking, drying.Therefore select 90% alcoholic solution containing 3%PVP as binding agent.
Described fumaric acid is lubricant, and for avoiding that suitability for industrialized production time slice heavily fluctuates greatly, the phenomenon such as sticking and slice difficulty, sheeting process is carried out smoothly, and granule must add lubricant before tabletting.Conventional lubricant has polyethylene glycol 6000, fumaric acid, sodium lauryl sulphate, silicon dioxide etc., although polyethylene glycol 6000 lubricity and resistance to bond are pretty good, but addition is DeGrain below 3%, and can foam be produced during effervescent, extend the effervescent time.Fumaric acid does not have hygroscopicity, and there is fabulous lubrication, fumaric acid itself is a kind of acid source, faintly acid, have salubrious tart flavour after dissolving, weak point is water solublity is not fine, and the fumaric acid tabletting adding 3% can carry out smoothly, substantially without undissolved fumaric acid after effervescent, mouthfeel is salubriouser.Therefore select fumaric acid as the lubricant of effervescent tablet, mix with granule before tabletting, addition is 3%.
Detailed description of the invention
Below in conjunction with embodiment, the invention will be further described, but the present invention is not limited.
Embodiment 1:
The present invention has the preparation method of the effervescent tablet of effect of relieving inflammation or internal heat:
1, produce extract: Flos Lonicerae, Flos Chrysanthemi add 10 times of water gagings, soak 30min, 100 DEG C of decoctions, decoct twice, each 1 hour, filtrate merges, filtrate is concentrated into relative density 1.10 ~ 1.15%, and add 95% ethanol precipitate with ethanol, concentrate, drying under reduced pressure becomes dry cream and is ground into powdery;
2, granulate: citric acid 25%, vitamin C 0.25% are pulverized rear mixing, granule is made with 90% alcoholic solution containing 3% polyvinylpyrrolidone (PVP), with 40 mesh sieve granulate, at 50 DEG C, forced air drying is to water content < 3%; Sodium bicarbonate 15%, lactose 10.75%, stevioside 2% are mixed, granule is made with 90% alcoholic solution containing 3% polyvinylpyrrolidone (PVP), with 40 mesh sieve granulate, at 50 DEG C, forced air drying is to water content < 3%.
3, tabletting: the two kinds of granules getting above-mentioned drying are mixed homogeneously with Flos Lonicerae, Flos Chrysanthemi mixed extract powder 20%, pear fruit powder 10%, pear essence 1% and fumaric acid 3%, enter tabletting machine, every sheet 4 grams.
4, pack: the effervescent tablet pressed is packed, 20 every bottle.
The effervescent tablet monolithic that the present invention makes weighs 4 grams, uniform color, and hardness is moderate, is dissolved in 200ml warm water or cold water, sour and sweet palatability, and carbon dioxide is sufficient, mouthfeel of stopping, and has light pear fragrance.And use through dry pharynx, pharyngalgia person, prove that there is good effect of relieving inflammation or internal heat.
Efficacy detection is carried out to the effect of the effervescent tablet that above-described embodiment obtains, chooses 20 routine pure gingival swelling and pain patients, wherein male 7 example, women 13 example; At 20-50 years old ages, every patient takes the effervescent tablet 3 ~ 5 of the embodiment of the present invention 1 every day, continues one week, effective 12 examples, effective 8 examples.
Embodiment 2:
The present invention has the preparation method of the effervescent tablet of effect of relieving inflammation or internal heat:
1, produce extract: Flos Lonicerae, Flos Chrysanthemi add 10 times of water gagings, soak 30min, 100 DEG C of decoctions, decoct twice, each 1 hour, filtrate merges, filtrate is concentrated into relative density 1.10 ~ 1.15%, and add 95% ethanol precipitate with ethanol, concentrate, drying under reduced pressure becomes dry cream and is ground into powdery;
2, granulate: citric acid 15%, vitamin C 0.1% are pulverized rear mixing, granule is made with 90% alcoholic solution containing 3% polyvinylpyrrolidone (PVP), with 40 mesh sieve granulate, at 50 DEG C, forced air drying is to water content < 3%; Sodium bicarbonate 10%, lactose 37.4%, stevioside 1% are mixed; Make granule with 90% alcoholic solution containing 3% polyvinylpyrrolidone (PVP), with 40 mesh sieve granulate, at 50 DEG C, forced air drying is to water content < 3%.
3, tabletting: the two kinds of granules getting above-mentioned drying are mixed homogeneously with Flos Lonicerae, Flos Chrysanthemi mixed extract powder 10%, pear fruit powder 20%, pear essence 0.5% and fumaric acid 3%, enter tabletting machine, every sheet 4 grams.
4, pack: the effervescent tablet pressed is packed, 20 every bottle.
Embodiment 3:
The present invention has the preparation method of the effervescent tablet of effect of relieving inflammation or internal heat:
1, produce extract: Flos Lonicerae, Flos Chrysanthemi add 10 times of water gagings, soak 30min, 100 DEG C of decoctions, decoct twice, each 1 hour, filtrate merges, filtrate is concentrated into relative density 1.10 ~ 1.15%, and add 95% ethanol precipitate with ethanol, concentrate, drying under reduced pressure becomes dry cream and is ground into powdery;
2, granulate: citric acid 20%, vitamin C 0.15% are pulverized rear mixing, granule is made with 90% alcoholic solution containing 3% polyvinylpyrrolidone (PVP), with 40 mesh sieve granulate, at 50 DEG C, forced air drying is to water content < 3%; Sodium bicarbonate 13%, lactose 28.55%, stevioside 1.5% are mixed, granule is made with 90% alcoholic solution containing 3% polyvinylpyrrolidone (PVP), with 40 mesh sieve granulate, at 50 DEG C, forced air drying is to water content < 3%.
3, tabletting: the two kinds of granules getting above-mentioned drying are mixed homogeneously with Flos Lonicerae, Flos Chrysanthemi mixed extract powder 15%, pear fruit powder 15%, pear essence 0.8% and fumaric acid 3%, enter tabletting machine, every sheet 4 grams.
4, pack: the effervescent tablet pressed is packed, 20 every bottle.
Claims (4)
1. one kind has the effervescent tablet of function of relieving inflammation or internal heat, it is characterized in that by mass percentage, comprise pear fruit powder 10 ~ 20%, Flos Lonicerae, Flos Chrysanthemi mixed extract 10 ~ 20%, vitamin C 0.1 ~ 0.25%, citric acid 15 ~ 25%, sodium bicarbonate 10 ~ 15%, lactose 10.75 ~ 37.4%, fumaric acid 3%, stevioside 1 ~ 2%, polyvinylpyrrolidone 3%, essence for food 0.5 ~ 1%.
2. have a preparation method for the effervescent tablet of function of relieving inflammation or internal heat, its step comprises:
A, decoction and alcohol sedimentation technique prepare Flos Lonicerae, Flos Chrysanthemi powdery mixed extract;
B, citric acid, vitamin C mix after pulverizing, granulate with the alcoholic solution of PVP, the alcoholic solution of the rear PVP of sodium bicarbonate, lactose, stevioside mixing is granulated, above granule takes according to quantity, and take Flos Lonicerae, Flos Chrysanthemi mixed extract powder, pear fruit powder, add fumaric acid and essence for food mix homogeneously tabletting, packaging.
3. the preparation method with the effervescent tablet of function of relieving inflammation or internal heat according to claim 2, it is characterized in that: in described steps A, Flos Lonicerae, Flos Chrysanthemi add 10 times of water gagings, soak 30min, 100 DEG C of decoctions, decoct twice, each 1 hour, filtrate merges, filtrate is concentrated into relative density 1.10 ~ 1.15%, adds 95% ethanol precipitate with ethanol, concentrates, drying under reduced pressure powdering.
4. having according to Claims 2 or 3 is relieved inflammation or internal heat the preparation method of effervescent tablet of function, it is characterized in that: the alcoholic solution of described PVP is 90% alcoholic solution of the PVP of 3%.
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| CN105685759A (en) * | 2016-03-13 | 2016-06-22 | 南京优能生物科技有限公司 | Effervescent tablets with lung heat clearing function and preparation method of effervescent tablets |
| CN105747219A (en) * | 2016-03-13 | 2016-07-13 | 南京优能生物科技有限公司 | Effervescent tablet with bone strengthening function and method for preparing effervescent tablet |
| CN108992480A (en) * | 2018-07-02 | 2018-12-14 | 郑州博凯医药保健品有限公司 | Honeysuckle chrysanthemum effervescent tablets and preparation method thereof |
| CN112715711A (en) * | 2020-12-31 | 2021-04-30 | 上海大学 | Health-care type toona sinensis effervescent tablets and preparation method thereof |
| CN115251273A (en) * | 2022-08-11 | 2022-11-01 | 亳州学院 | Mandarin duck rattan effervescent tablet and preparation method thereof |
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| CN103462002A (en) * | 2013-08-13 | 2013-12-25 | 深圳市麦金利实业有限公司 | Vitamin c effervescent tablet and preparation method thereof |
| CN104432060A (en) * | 2014-12-18 | 2015-03-25 | 郑州拓洋实业有限公司 | High-zinc and low-sodium vitamin C effervescent tablet and preparation method thereof |
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| CN101361585A (en) * | 2007-07-26 | 2009-02-11 | 刘洪生 | Honeysuckle effervescence decoction piece and manufacture technique thereof |
| CN102551169A (en) * | 2012-02-03 | 2012-07-11 | 湖北武当生物医药科技有限公司 | Formula and production method of effervescent tablet containing honeysuckle and chrysanthemum |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105685759A (en) * | 2016-03-13 | 2016-06-22 | 南京优能生物科技有限公司 | Effervescent tablets with lung heat clearing function and preparation method of effervescent tablets |
| CN105747219A (en) * | 2016-03-13 | 2016-07-13 | 南京优能生物科技有限公司 | Effervescent tablet with bone strengthening function and method for preparing effervescent tablet |
| CN108992480A (en) * | 2018-07-02 | 2018-12-14 | 郑州博凯医药保健品有限公司 | Honeysuckle chrysanthemum effervescent tablets and preparation method thereof |
| CN112715711A (en) * | 2020-12-31 | 2021-04-30 | 上海大学 | Health-care type toona sinensis effervescent tablets and preparation method thereof |
| CN115251273A (en) * | 2022-08-11 | 2022-11-01 | 亳州学院 | Mandarin duck rattan effervescent tablet and preparation method thereof |
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