CN100556401C - Effervescence tablet for cold - Google Patents
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- CN100556401C CN100556401C CNB2005100195208A CN200510019520A CN100556401C CN 100556401 C CN100556401 C CN 100556401C CN B2005100195208 A CNB2005100195208 A CN B2005100195208A CN 200510019520 A CN200510019520 A CN 200510019520A CN 100556401 C CN100556401 C CN 100556401C
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Abstract
The present invention relates to the particularly annular effervescence tablet for cold of effervescence tablet for cold.Medicine of the present invention is a raw material with Rhizoma Atractylodis, Radix Bupleuri, Rhizoma Et Radix Notopterygii, Radix Saposhnikoviae, the Radix Angelicae Dahuricae, Rhizoma Chuanxiong, Herba Pogostemonis, Radix Peucedani, Fructus Forsythiae, Pericarpium Citri Reticulatae, Fructus Crataegi, Fructus Aurantii Immaturus, Fructus Hordei Germinatus (stir-fry), Radix Glycyrrhizae, Radix Platycodonis, Massa Medicata Fermentata (stir-fry), Folium Perillae, Cortex Magnoliae Officinalis, black tea, through preparing effervescence tablet for cold, its effect is to separate in the harmony in the exterior, be used to be affected by the cold, the internal injury food stagnation, cold and heat are vomited and diarrhoea, and have improved bioavailability, and have be easy to oral, dosage is little, characteristics such as easy to carry.Preferred adjuvant of the present invention and annular effervescent tablet can make the rapid disintegrate of effervescence tablet for cold.
Description
Technical field
The present invention relates to the technical field of Chinese patent medicine effervescent tablet, relate in particular to effervescence tablet for cold.
Background technology
At present, the domestic main effervescent tablet of China is health product, as vitamin C, the effervescent tablet of replenishing the calcium, also has plenty of the effervescent tablet of gynecological external use medicine, as JIEERYIN PAOTENGPIAN, and metronidazole vagina effervescent tablet etc., but the oral Chinese medicine effervescent formulation is less.And with the period of the day from 11 a.m. to 1 p.m tea prescription make the effervescent tablet of oral pure Chinese medicinal preparation, rarely found report.In addition, ring segment early has application in food industry, but less in the field of medicaments application, particularly in the effervescent tablet preparation field, and rarely found report.
The Chinese medicine effervescent tablet is a kind of new dosage form, have that drug release rate is fast, dosage is little, divided dose is accurate, take, advantage such as easy to carry, and the oral administration effervescing sheet is specially adapted to the patient of child, old people and the solid preparation of can not swallowing.
The period of the day from 11 a.m. to 1 p.m, the effect of teas Chinese patent medicine was to separate in the harmony in the exterior, is used to be affected by the cold, and the internal injury food stagnation, cold and heat are vomited and diarrhoea.Former dosage form is a granule, carries inconvenience.
The period of the day from 11 a.m. to 1 p.m, the raw material of Chinese medicine of tea was made up of Rhizoma Atractylodis, Radix Bupleuri, Rhizoma Et Radix Notopterygii, Radix Saposhnikoviae, the Radix Angelicae Dahuricae, Rhizoma Chuanxiong, Herba Pogostemonis, Radix Peucedani, Fructus Forsythiae, Pericarpium Citri Reticulatae, Fructus Crataegi, Fructus Aurantii Immaturus, Fructus Hordei Germinatus (stir-fry), Radix Glycyrrhizae, Radix Platycodonis, Massa Medicata Fermentata (stir-fry), Folium Perillae, Cortex Magnoliae Officinalis, black tea.
Conventional Chinese medicine effervescent tablet adopts the form of conventional tablet, and disintegration rate is too slow, and the time that patient waits for is oversize, easily causes impatient emotion, influences Chinese medicine effervescent tablet commercial value.The administrative provisions of Chinese medicine effervescent tablet for example, the disintegration time of effervescent tablet is higher than 5 minutes, is judged to defective.This is because of slow excessively disintegration rate, inconvenient patient's treatment.
It is long partially that the health care products effervescent dosage form of Chinese medicine effervescent dosage form and other two big classes and Western medicine effervescent dosage form are compared on disintegration time, influenced the application of Chinese medicine effervescent dosage form.
Health product effervescent dosage form contains the material that easily is dissolved in water mostly, for example easily is dissolved in the small-molecule substance and the inorganic compound of water, and disintegrate is very fast; The common dose of Western medicine is little, and easily is dissolved in water, and Western medicine only accounts for below 3% of Western medicine effervescent formulation weight usually, and all the other all can adopt acid, alkali disintegrating agent, and sour, alkali disintegrating agent can be up to more than 90%, so the disintegrate of Western medicine effervescent chance water is also very fast; Health care products effervescent dosage form and Western medicine effervescent dosage form even are finished disintegrate usually in one minute in the several seconds, therefore do not have the technical problem of poor practicability on disintegration time.And Chinese medicine is when making the effervescent dosage form, usually water is carried with alcohol extraction and is obtained multiple blended macromolecular active substance, comprise multiple stickums such as pectin class, saccharide, polysaccharide, Chinese medicine effervescent dosage form is met the influence that the water disintegrate is subjected to stickum, disintegrate is slower, on the other hand for guaranteeing curative effect, the Chinese medicine effervescent dosage form dose of monolithic is bigger, this has also influenced disintegration rate, for guaranteeing disintegrate, have to increase the consumption of adjuvant, make some effervescent tablet will accomplish the 4-5g/ sheet, not only increased cost, also made troubles to producing, transport, carry, using.After the disintegration rate of Chinese medicine effervescent reached several minutes, compare advantage with Chinese medicine granules not outstanding, limited the application of Chinese medicine effervescent.
Summary of the invention
The purpose of this invention is to provide a kind of effervescence tablet for cold,, satisfy needs of medical treatment better to overcome the deficiency of present dosage form.
Particularly provide a kind of disintegration rate the fast tea annular effervescent tablet period of the day from 11 a.m. to 1 p.m.
Each constituent of effervescence tablet for cold of the present invention comprises the tea extract period of the day from 11 a.m. to 1 p.m, disintegrating agent and other adjuvant, and the tea extract period of the day from 11 a.m. to 1 p.m is wherein made by the following weight Chinese medicinal raw materials: Rhizoma Atractylodis 10-50, Radix Bupleuri 10-50, Rhizoma Et Radix Notopterygii 10-50, Radix Saposhnikoviae 10-50, Radix Angelicae Dahuricae 10-50, Rhizoma Chuanxiong 10-50, Herba Pogostemonis 10-50, Radix Peucedani 10-50, Fructus Forsythiae 10-50, Pericarpium Citri Reticulatae 10-50, Fructus Crataegi 10-50, Fructus Aurantii Immaturus 10-50, Fructus Hordei Germinatus (stir-fry) 20-60 Radix Glycyrrhizae 10-50, Radix Platycodonis 20-60, Massa Medicata Fermentata (stir-fry) 10-50, Folium Perillae 20-60, Cortex Magnoliae Officinalis 20-60, black tea 920-1000.
Each constituent of effervescence tablet for cold of the present invention comprises the tea extract period of the day from 11 a.m. to 1 p.m, disintegrating agent and other adjuvant, and the tea extract period of the day from 11 a.m. to 1 p.m is wherein made by the following weight Chinese medicinal raw materials: Rhizoma Atractylodis 30, Radix Bupleuri 30, Rhizoma Et Radix Notopterygii 30, Radix Saposhnikoviae 30, the Radix Angelicae Dahuricae 30, Rhizoma Chuanxiong 30, Herba Pogostemonis 30, Radix Peucedani 30, Fructus Forsythiae 30, Pericarpium Citri Reticulatae 30, Fructus Crataegi 30, Fructus Aurantii Immaturus 30, Fructus Hordei Germinatus (stir-fry) 45, Radix Glycyrrhizae 30, Radix Platycodonis 45, Massa Medicata Fermentata (stir-fry) 30, Folium Perillae 45, Cortex Magnoliae Officinalis 45, black tea 960.
Effervescence tablet for cold, wherein each constituent proportioning is by weight: the period of the day from 11 a.m. to 1 p.m tea extract 1-50 part, disintegrating agent comprises sour agent 10-30 part, alkaline agent 10-30 part, other adjuvant comprises binding agent 0-15 part, lubricant 0-15 part, sweeting agent 0-10 part, aromatic 0-5 part.
Effervescence tablet for cold, wherein the effervescent tablet profile is an annular.
The annular of effervescence tablet for cold is made up of some bursts; Be provided with the connecting band of easy fracture between each burst.Disintegration rate can be further accelerated in the setting of connecting band between the burst.
An important feature of the present invention is that ring segment is incorporated into the effervescence tablet for cold preparation field, has invented the tea annular effervescent tablet period of the day from 11 a.m. to 1 p.m.Contain various saccharides, polysaccharide macromolecular material the period of the day from 11 a.m. to 1 p.m in the tea medical material, so the tea extract period of the day from 11 a.m. to 1 p.m that makes after the drying has very strong viscosity.After being made into effervescence tablet for cold, these materials form one deck adhesive film in tablet surface easily when effervescent tablet is met the water disintegrate, influence the disintegration rate of effervescent tablet.After being made into ring segment, increased the contact surface of disintegrating agent and water, made disintegrating agent outer two aspects and water effect of ring in ring, increased the contact surface with water, made effervescent tablet complete disintegrate in the short time.
Because health care products effervescent dosage form and Western medicine effervescent dosage form are very fast because of self Material Characteristics disintegrate, health care products effervescent dosage form and Western medicine effervescent dosage form are made the technical meaning that ring segment further improves disintegration rate do not give prominence to.But to effervescence tablet for cold, be made into annular, but can improve disintegration rate greatly, significant, the annular effervescence tablet for cold of disintegrate had both met national standard in two minutes even in one minute, can satisfy patient's demand easy to use again; Need the disintegrate of 4-5 minute ability to compare with common effervescence tablet for cold, the commercial value of annular effervescence tablet for cold aspect the disintegrate convenience is higher.
The acid agent can be selected from one or more in tartaric acid, malic acid, fumaric acid, anhydrous citric acid, citric acid or the sodium dihydrogen citrate salt; Alkaline agent can be selected from one or more in potassium carbonate, potassium bicarbonate, sodium carbonate, sodium bicarbonate, calcium carbonate, the calcium bicarbonate; Binding agent can be selected from carboxymethylstach sodium, hyprolose, carmethose, low-substituted hydroxypropyl cellulose (L-HPC), microcrystalline Cellulose (MCC), crospolyvinylpyrrolidone (PVPP), polyvinylpyrrolidone (PVP), Polyethylene Glycol (PEG) 6000, Polyethylene Glycol (PEG) 4000.
Lubricant can be selected from one or more in sodium lauryl sulphate, magnesium stearate, Pulvis Talci, the silicon dioxide.
In the additive of tablet field, materials such as Polyethylene Glycol (PEG) 6000, Polyethylene Glycol (PEG) 4000 have the effect of binding agent, lubricant simultaneously concurrently.It is divided into binding agent or lubricant all belongs to normal.
In the additive of tablet field, have the effect that binding agent, speed collapse agent simultaneously concurrently as carboxymethylstach sodium, hyprolose, carmethose, low-substituted hydroxypropyl cellulose (L-HPC), microcrystalline Cellulose (MCC), crospolyvinylpyrrolidone (PVPP), the polyvinylpyrrolidone (PVP) of binding agent.It is divided into binding agent or speed collapses agent and all belongs to normal.
Sweeting agent can be selected from one or more in cyclamate, steviosin, acesulfame potassium, aspartame, protein sugar, sucrose, the saccharin sodium (calcium) etc.
Aromatic can be selected from one or more among orange essence, flavoring orange essence, Herba Menthae essence or Fructus Citri Limoniae essence, the flavoring banana essence etc.
Effervescent tablet of the present invention was taken after every day, three times consumption was dissolved in water by each 1-3 sheet.
Being conventional substances because sour agent, alkaline agent, binding agent, lubricant, sweeting agent, aromatic, the speed in effervescent tablet field collapse the kind of agent, is not emphasis of the present invention.So the present invention does not do detailed expansion to this partial content.
Effervescence tablet for cold of the present invention can be by following three kinds of methods preparation, and concrete steps are:
Method one: (1) spray-dried airtight preservation of the tea extract period of the day from 11 a.m. to 1 p.m that obtains is standby; Sour agent, alkaline agent, binding agent pulverize separately are crossed the 80-100 mesh sieve, and airtight preservation is standby; Sweeting agent and aromatic were pulverized the 100-120 mesh sieve, and lubricant was pulverized the 140-200 mesh sieve; In the preparation process control preparation ambient temperature at 25 ℃, humidity below 45%; (2) press required proportioning with the period of the day from 11 a.m. to 1 p.m tea extract and sour agent mix homogeneously, or add sweeting agent again or/and the aromatic mix homogeneously gets powders A 1; (3), get powder B1 with the alkaline agent mix homogeneously; (4) powders A 1 is mixed with powder B1, add lubricant, fully mixing; (5) with the 4th step gained mixed-powder tabletting, obtain required effervescence tablet for cold.
Method two: (1) spray-dried airtight preservation of the tea extract period of the day from 11 a.m. to 1 p.m that obtains is standby; Sour agent, alkaline agent, binding agent pulverize separately are crossed the 80-100 mesh sieve, and airtight preservation is standby; Sweeting agent and aromatic were pulverized the 100-120 mesh sieve, and lubricant was pulverized the 140-200 mesh sieve; In the preparation process control preparation ambient temperature at 25 ℃, humidity below 45%; (2) press required proportioning with the period of the day from 11 a.m. to 1 p.m tea extract and sour agent mix homogeneously, or add sweeting agent again, get granule A2 or/and the aromatic mix homogeneously is granulated; (3), granulate with the alkaline agent mix homogeneously; Get granule B2; (4) granule A2 is mixed with granule B2, add lubricant, fully mixing; (5) with the 4th step gained hybrid particles tabletting, obtain required effervescence tablet for cold.
Method three: (1) spray-dried airtight preservation of the tea extract period of the day from 11 a.m. to 1 p.m that obtains is standby; Sour agent, alkaline agent, binding agent pulverize separately are crossed the 80-100 mesh sieve, and airtight preservation is standby; Sweeting agent and aromatic were pulverized the 100-120 mesh sieve, and lubricant was pulverized the 140-200 mesh sieve; In the preparation process control preparation ambient temperature at 25 ℃, humidity below 45%; (2) press required proportioning with the period of the day from 11 a.m. to 1 p.m tea extract and sour agent mix homogeneously, or add sweeting agent again or/and the aromatic mix homogeneously gets powders A 3; (3), get powder B3 with the alkaline agent mix homogeneously; (4) powders A 3 is mixed with powder B3, add lubricant, fully mixing; (5) the 4th step gained mixed-powder is added non-aqueous solution (as ethanol, isopropyl alcohol etc.) pelletizing press sheet, obtain required effervescence tablet for cold.
Experimental example:
The tea extract 80g period of the day from 11 a.m. to 1 p.m that the spray drying of learning from else's experience respectively obtains, the citric acid 50g that pulverized 100 mesh sieves, sodium bicarbonate 55g, low-substituted hydroxypropyl cellulose (L-HPC) 10g, the PEG40005g that pulverized 120 mesh sieves make the effervescence tablet for cold of about 4g/ sheet by above-mentioned three kinds of preparation methoies, in the preparation process control preparation ambient temperature at 25 ℃, humidity below 45%.Prepared effervescence tablet for cold is with reference to " 2000 editions one appendix XIIA inspection technique disintegration of Chinese pharmacopoeia detects, and the result is up to specification.
Check result disintegration of three kinds of preparation method gained effervescence tablet for cold
An important feature of the present invention is that the tablet speed commonly used that has added other in the pelletization collapses agent (also having the binding agent effect concurrently) as low-substituted hydroxypropyl cellulose (L-HPC), as can be seen from the table, prepare effervescence tablet for cold by above-mentioned three kinds of methods, the effervescent tablet that adds L-HPC is shorter than the effervescent tablet disintegration time that does not add L-HPC, and can significantly improve disintegration rate after making annular effervescent tablet.
Other gets above-mentioned raw materials, is pressed into the annular effervescence tablet for cold of being made up of connecting band between some bursts and the burst.Contrast disintegration with common annular effervescence tablet for cold:
In the above-mentioned preparation method, granulating process can adopt methods such as wet granulation, dry granulation, one-step palletizing when big production.
The effervescent tablet of preparation health:
(1) it is standby to get the airtight preservation of vitamin C 10g.Citric acid 150g, sodium bicarbonate 100g, sodium carbonate 10g pulverize separately are crossed 100 mesh sieves, and airtight preservation is standby; Aspartame 8g and essence 1g pulverized 100 mesh sieves, and PEG 600021g pulverized 140 mesh sieves; In the preparation process control preparation ambient temperature at 25 ℃, humidity below 45%; With vitamin C and citric acid mix homogeneously, add steviosin and essence mix homogeneously by required proportioning again, granulate, get granule A; With sodium bicarbonate, sodium carbonate mix homogeneously, granulate, get granule B; Granule A is mixed with granule B, add PEG 6000, fully mixing; The gained hybrid particles is divided into identical two parts, and tabletting gets 50 of 50 of solid effervescent tablets of vitamin C and vitamin C annular effervescent tablets.
Adopt method for preparing other than ring type be that solid vitamin C effervescent tablet and vitamin C annular effervescent tablet is about the 3g/ sheet, the outer ring diameter of wherein annular effervescent dosage form is 20 millimeters, interior ring diameter is 8 millimeters.
(2) the airtight preservation of extracting lactic acid calcium 10g is standby.Citric acid 150g, sodium bicarbonate 100g, sodium carbonate 10g pulverize separately are crossed 100 mesh sieves, and airtight preservation is standby; Aspartame 8g and essence 1g pulverized 100 mesh sieves, and PEG 600021g pulverized 140 mesh sieves; In the preparation process control preparation ambient temperature at 25 ℃, humidity below 45%; With calcium lactate and citric acid mix homogeneously, add steviosin and essence mix homogeneously by required proportioning again, granulate, get granule A; With sodium bicarbonate, sodium carbonate mix homogeneously, granulate, get granule B; Granule A is mixed with granule B, add PEG 6000, fully mixing; The gained hybrid particles is divided into identical two parts, and tabletting gets 50 of 50 of solid effervescent tablets of calcium lactate and calcium lactate annular effervescent tablets.
Adopt method for preparing other than ring type be that solid calcium lactate effervescent tablet and calcium lactate annular effervescent tablet is about the 3g/ sheet, the outer ring diameter of wherein annular effervescent dosage form is 20 millimeters, interior ring diameter is 8 millimeters.
With reference to " 2000 editions one appendix XIIA inspection technique disintegration of Chinese pharmacopoeia is checked, 25 ℃ of a slice effervescent tablet inputs are filled in the 250ml beaker of 200ml water, there are a large amount of bubbles to emit immediately, tablet dissolves, is scattered in the water rapidly, formed even or clear solution in 5 minutes, it is left not have accumulative granule.Check respectively 6 all qualified, the result is up to specification.
Check result disintegration of two kinds of vitamin C effervescent tablets
Check result disintegration of two kinds of calcium lactate effervescent tablets
As can be known from the results, the vitamin C effervescent tablet of health, calcium lactate effervescent tablet, do not relate to curative effect, every contained vitamin C or calcium lactate are less, and there is not the interference of the multiple stickum such as pectin class, saccharide, polysaccharide of Chinese medicine, so disintegration rate is fast, there is not the slow technical barrier of similar Chinese medicine effervescent tablet disintegration rate.The effervescent tablet of health is prepared into the effect that annular has only novelty attractive in appearance, adopts annular and other than ring type vitamin C or calcium lactate effervescent tablet, it is limited to compare the disintegration rate raising, does not have obvious technological progress.
The dose of Western medicine is less, and is similar with vitamin C, the calcium lactate effervescent tablet of health aspect the disintegration rate raising, and annular is compared the disintegration rate raising with other than ring type Western medicine effervescent tablet limited, do not have obvious technological progress.
The present invention uses the modern pharmaceutical technology, it is carried out the dosage form process modification, thereby obtain a kind of effervescence tablet for cold, many weak points of original dosage form have been remedied, and make it become a kind of production technology by optimization more to become fully rationally, quality is easy to control, and drug release rate is fast, the bioavailability height carries, the tea new formulation period of the day from 11 a.m. to 1 p.m of taking convenience.
Each burst and connecting band can will be stamped to form after the medicated powder filling by the corresponding mould of design, and the realization of this technology can just can be finished by corresponding simple mould design.
The disintegration rate of solid Chinese medicine effervescent reaches several minutes, compare advantage with Chinese medicine granules not outstanding, its practicality is very poor, has limited the application of solid Chinese medicine effervescent, and Here it is does not see one of major reason of Chinese medicine being made oral annular effervescent dosage form report for a long time.When annular Chinese medicine effervescent dosage form was compared the obvious raising of disintegration rate with solid effervescent tablet after, its practicality improved greatly, can satisfy the demand of consumption market.Because health care products effervescent dosage form and Western medicine effervescent dosage form are very fast because of self Material Characteristics disintegrate, health care products effervescent dosage form and Western medicine effervescent dosage form are made the technical meaning that ring segment further improves disintegration rate do not give prominence to.But to the Chinese medicine effervescent tablet, be made into annular, but can improve disintegration rate greatly, significant, the annular Chinese medicine effervescent tablet of disintegrate had both met national standard in two minutes even in one minute, can satisfy patient's demand easy to use again; Need the disintegrate of 4-5 minute ability to compare with solid Chinese medicine effervescent tablet, the commercial value of annular Chinese medicine effervescent tablet aspect the disintegrate convenience is higher.
Specific embodiment
Embodiment 1
1, the period of the day from 11 a.m. to 1 p.m tea extract preparation: get 30 parts of Rhizoma Atractylodis, 30 parts of Radix Bupleuri, 30 parts of Rhizoma Et Radix Notopterygiis, 30 parts of Radix Saposhnikoviaes, 30 parts of the Radixs Angelicae Dahuricae, 30 parts of Rhizoma Chuanxiongs, 30 parts of Herba Pogostemonis, 30 parts of Radix Peucedanis, 30 parts of Fructus Forsythiaes, 30 parts of Pericarpium Citri Reticulataes, 30 parts of Fructus Crataegis, 30 parts of Fructus Aurantii Immaturuss, 45 parts in Fructus Hordei Germinatus (stir-fry), 30 parts in Radix Glycyrrhizae, 45 parts of Radix Platycodoniss, 30 parts of Massa Medicata Fermentatas (stir-fry), 45 parts of Folium Perillaes, 45 parts of Cortex Magnoliae Officinalis, 960 parts of black tea.Rhizoma Atractylodis, Radix Bupleuri, Rhizoma Et Radix Notopterygii, Radix Saposhnikoviae, the Radix Angelicae Dahuricae, Rhizoma Chuanxiong, Herba Pogostemonis, Fructus Forsythiae, Radix Peucedani, Pericarpium Citri Reticulatae, Fructus Aurantii Immaturus, Folium Perillae, Cortex Magnoliae Officinalis are extracted volatile oil, and the aqueous solution after distillation device is in addition collected; Six-element such as medicinal residues and Fructus Crataegi, decoct with water secondary, 2 hours for the first time, 1 hour for the second time, collecting decoction, filter, filtrate is left standstill, and gets supernatant and above-mentioned aqueous solution and merges, be concentrated into an amount of, add ethanol equivalent and make precipitation, get after the supernatant spray drying again that spray adds volatile oil mixings such as above-mentioned Rhizoma Atractylodis, promptly obtain the tea extract period of the day from 11 a.m. to 1 p.m.Obtain 120 parts of the tea extracts period of the day from 11 a.m. to 1 p.m altogether, yield 7.7%.
2, the preparation tea effervescent solid sheet period of the day from 11 a.m. to 1 p.m (100)
The prescription proportioning:
The period of the day from 11 a.m. to 1 p.m tea extract 120g citric acid 115g
Steviosin 3g essence 1g
Sodium bicarbonate 95g sodium carbonate 10g
Low-substituted hydroxypropyl cellulose 35g PEG 600021g
3, preparation method
The spray-dried airtight preservation of the tea extract period of the day from 11 a.m. to 1 p.m that obtains is standby; Citric acid, sodium bicarbonate, sodium carbonate, low-substituted hydroxypropyl cellulose pulverize separately are crossed 100 mesh sieves, and airtight preservation is standby; Steviosin and essence were pulverized 100 mesh sieves, and PEG 6000 pulverized 140 mesh sieves; In the preparation process control preparation ambient temperature at 25 ℃, humidity below 45%; With the period of the day from 11 a.m. to 1 p.m tea extract and citric acid mix homogeneously, add steviosin and essence mix homogeneously by required proportioning again, get powders A 1; With sodium bicarbonate, sodium carbonate mix homogeneously, get powder B1; Powders A 1 is mixed with powder B1, add low-substituted hydroxypropyl cellulose, PEG 6000, fully mixing; Be pressed into solid sheet, get 100 of effervescence tablet for cold.
The average sheet of gained effervescence tablet for cold heavily is 4.00 ± 0.04g, any surface finish, exquisiteness.With reference to " 2000 editions one appendix XIIA inspection technique disintegration of Chinese pharmacopoeia is checked this product, 25 ℃ of a slice effervescent tablet inputs are filled in the 250ml beaker of 200ml water, there are a large amount of bubbles to emit immediately, tablet dissolves, is scattered in the water rapidly, formed light yellow transparent solution in 6 minutes, it is left not have accumulative granule.
Embodiment 2
1, the period of the day from 11 a.m. to 1 p.m tea extract preparation: with embodiment 1.
2, the annular effervescent tablet (100) of the tea period of the day from 11 a.m. to 1 p.m
The prescription proportioning:
The period of the day from 11 a.m. to 1 p.m tea extract 85g tartaric acid 168g
Cyclamate 5g essence 2g
Sodium bicarbonate 80g PEG 40005g
Microcrystalline Cellulose 30g PVP 25g
3, preparation method
The spray-dried airtight preservation of the tea extract period of the day from 11 a.m. to 1 p.m that obtains is standby; Tartaric acid, sodium bicarbonate, microcrystalline Cellulose pulverize separately are crossed 100 mesh sieves, and airtight preservation is standby; Cyclamate and essence were pulverized 100 mesh sieves, and PEG 4000 pulverized 140 mesh sieves; In the preparation process control preparation ambient temperature at 25 ℃, humidity below 45%; With the period of the day from 11 a.m. to 1 p.m tea extract and tartaric acid mix homogeneously, add cyclamate and essence mix homogeneously by required proportioning again, get powders A 2; With the sodium bicarbonate mix homogeneously, get powder B2; Powders A 2 is mixed with powder B2, add microcrystalline Cellulose, PEG 4000, fully mixing; The gained mixed-powder is granulated with the alcoholic solution of 3% PVP, tabletting, the period of the day from 11 a.m. to 1 p.m 100 of tea annular effervescent tablets.
The average sheet of gained tea period of the day from 11 a.m. to 1 p.m annular effervescent tablet heavily is 4.02 ± 0.03g, any surface finish, exquisiteness.With reference to " 2000 editions one appendix XIIA inspection technique disintegration of Chinese pharmacopoeia is checked this product, 25 ℃ of a slice effervescent tablet inputs are filled in the 250ml beaker of 200ml water, there are a large amount of bubbles to emit immediately, tablet dissolves, is scattered in the water rapidly, formed light yellow transparent solution in 5 minutes, it is left not have accumulative granule.Check 6 all qualified, the result is up to specification.
Embodiment 3
1, the period of the day from 11 a.m. to 1 p.m tea extract preparation: with embodiment 1.
2, preparation tea period of the day from 11 a.m. to 1 p.m annular effervescent tablet (100)
The prescription proportioning:
The period of the day from 11 a.m. to 1 p.m tea extract 55g malic acid 40g citric acid 115g
Aspartame 5g acesulfame potassium 3g essence 2g
Sodium bicarbonate 40g potassium carbonate 90g
Crospolyvinylpyrrolidone 35g magnesium stearate 15g
3, preparation method
The spray-dried airtight preservation of the tea extract period of the day from 11 a.m. to 1 p.m that obtains is standby; Malic acid, citric acid, sodium bicarbonate, potassium carbonate, crospolyvinylpyrrolidone pulverize separately are crossed 100 mesh sieves, and airtight preservation is standby; Acesulfame potassium and essence were pulverized 100 mesh sieves, and magnesium stearate was pulverized 140 mesh sieves; In the preparation process control preparation ambient temperature at 25 ℃, humidity below 45%; With the period of the day from 11 a.m. to 1 p.m tea extract and malic acid mix homogeneously, add aspartame, acesulfame potassium and essence mix homogeneously by required proportioning again, granulate, get granule A3; With sodium bicarbonate, potassium carbonate mix homogeneously, granulate, get granule B3; Granule A3 is mixed with granule B3, add crospolyvinylpyrrolidone, magnesium stearate, fully mixing; Tabletting gets 100 of the annular effervescent tablets of the tea period of the day from 11 a.m. to 1 p.m.
The average sheet of gained effervescence tablet for cold heavily is 3.99 ± 0.04g, any surface finish, exquisiteness.With reference to " 2000 editions one appendix XII A of Chinese Pharmacopoeia inspection technique disintegration is checked this product, 25 ℃ of a slice effervescent tablet inputs are filled in the 250ml beaker of 200ml water, there are a large amount of bubbles to emit immediately, tablet dissolves, is scattered in the water rapidly, formed light yellow transparent solution in 5 minutes, it is left not have accumulative granule.Check 6 all qualified, the result is up to specification.
Embodiment 4
Effervescence tablet for cold, the composition of this effervescent tablet comprise the tea extract period of the day from 11 a.m. to 1 p.m, disintegrating agent and other adjuvant.
(1) the tea extract period of the day from 11 a.m. to 1 p.m is wherein made by the following weight Chinese medicinal raw materials: Rhizoma Atractylodis 50, Radix Bupleuri 10, Rhizoma Et Radix Notopterygii 50, Radix Saposhnikoviae 10, the Radix Angelicae Dahuricae 10, Rhizoma Chuanxiong 10, Herba Pogostemonis 50, Radix Peucedani 10, Fructus Forsythiae 50, Pericarpium Citri Reticulatae 10, Fructus Crataegi 50, Fructus Aurantii Immaturus 50, Fructus Hordei Germinatus (stir-fry) 20, Radix Glycyrrhizae 10, Radix Platycodonis 60, Massa Medicata Fermentata (stir-fry) 10, Folium Perillae 60, Cortex Magnoliae Officinalis 20, black tea 920.It is stand-by to obtain period of the day from 11 a.m. to 1 p.m tea extract by the method for embodiment 1, and its noon tea extract extraction ratio is 7.2%, and promptly the 7.2g tea extract period of the day from 11 a.m. to 1 p.m is equivalent to the 100g raw material of Chinese medicine.
(2) effervescence tablet for cold, each constituent proportioning is by weight:
Get 50 parts of the tea extracts period of the day from 11 a.m. to 1 p.m, disintegrating agent comprises 30 parts of sour agent, 30 parts of alkaline agents, 15 parts of lubricants, 10 parts of sweeting agents.
Sweeting agent is selected from 4 parts of steviosin, 2 parts of acesulfame potassiums, 4 parts of aspartames; The acid agent is selected from 14 parts of malic acids, 16 parts of anhydrous citric acids; Alkaline agent is selected from 15 parts of sodium bicarbonate, 15 parts of calcium bicarbonate; Lubricant is selected from 5 parts of sodium lauryl sulphates, 10 parts of magnesium stearate.All the other repeat embodiment 1,2,3 respectively.
Embodiment 5
(1) the tea extract period of the day from 11 a.m. to 1 p.m is wherein made by the following weight Chinese medicinal raw materials: Rhizoma Atractylodis 10, Radix Bupleuri 50, Rhizoma Et Radix Notopterygii 10, Radix Saposhnikoviae 50, the Radix Angelicae Dahuricae 50, Rhizoma Chuanxiong 50, Herba Pogostemonis 10, Radix Peucedani 50, Fructus Forsythiae 10, Pericarpium Citri Reticulatae 50, Fructus Crataegi 10, Fructus Aurantii Immaturus 10, Fructus Hordei Germinatus (stir-fry) 60, Radix Glycyrrhizae 50, Radix Platycodonis 20, Massa Medicata Fermentata (stir-fry) 50, Folium Perillae 20, Cortex Magnoliae Officinalis 60, black tea 1000.It is stand-by to obtain period of the day from 11 a.m. to 1 p.m tea extract by the method for embodiment 1, and its noon tea extract extraction ratio is 7.5%, and promptly the 7.5g tea extract period of the day from 11 a.m. to 1 p.m is equivalent to the 100g raw material of Chinese medicine.
(2) effervescence tablet for cold, each constituent proportioning is by weight:
Get above-mentioned stand-by period of the day from 11 a.m. to 1 p.m of 1 part of tea extract, disintegrating agent comprises 10 parts of sour agent, 10 parts of alkaline agents, 15 parts of binding agents, 5 parts of aromatic.
Aromatic wherein is selected from 2 parts of orange essences, 3 parts of flavoring orange essences.The acid agent is selected from 6 parts of citric acids, 4 parts in tartaric acid; Alkaline agent is selected from 2 parts of potassium carbonate, 1 part of potassium bicarbonate, 4 parts of sodium carbonate, 3 parts of sodium bicarbonate; Binding agent is selected from 10 parts of microcrystalline Cellulose, 5 parts of polyvinylpyrrolidones (PVP).All the other repeat embodiment 1,2,3 respectively.
Embodiment 6
Effervescence tablet for cold, each constituent proportioning is by weight: get 20 parts of the tea extracts period of the day from 11 a.m. to 1 p.m, disintegrating agent comprises 20 parts of sour agent, 20 parts of alkaline agents, 3 parts of binding agents, 4 parts of lubricants, 6 parts of sweeting agents, 3 parts of aromatic.
Sweeting agent is selected from 2 parts of steviosin, 2 parts of sucrose, 2 parts of Calcium o-benzolsulfimides; Aromatic is selected from respectively 1 part of Herba Menthae essence, Fructus Citri Limoniae essence, flavoring banana essence; The acid agent is selected from 10 parts in tartaric acid, 10 parts of malic acids; Alkaline agent is selected from 15 parts of sodium bicarbonate, 5 parts of sodium carbonate; Binding agent is selected from 1 part of microcrystalline Cellulose (MCC), 2 parts of crospolyvinylpyrrolidone (PVPP); Lubricant is selected from 3 parts of sodium lauryl sulphates, silica 1 part.All the other are with embodiment 3.
Embodiment 7
Get the effervescence tablet for cold of embodiment 1,2,3,4,5,6, it is prepared into outer ring diameter respectively is 30 millimeters, and interior ring diameter is 3 millimeters a ring segment.
Embodiment 8
Get the effervescence tablet for cold of embodiment 1,2,3,4,5,6, it is prepared into outer ring diameter respectively is 20 millimeters, and interior ring diameter is 8 millimeters a ring segment.
Embodiment 9
Get the effervescence tablet for cold of embodiment 1,2,3,4,5,6, it is prepared into outer ring diameter respectively is 25 millimeters, and interior ring diameter is 5 millimeters a ring segment.
Embodiment 10
Get the effervescence tablet for cold of embodiment 1,2,3,4,5,6, it is prepared into annular respectively forms, be provided with the ring segment of the connecting band of easy fracture between each burst by some bursts.
Claims (2)
1, a kind of effervescence tablet for cold, the composition that it is characterized in that this effervescent tablet by the period of the day from 11 a.m. to 1 p.m tea extract, disintegrating agent and other adjuvant form, the tea extract period of the day from 11 a.m. to 1 p.m is wherein made by the following weight Chinese medicinal raw materials: Rhizoma Atractylodis 30, Radix Bupleuri 30, Rhizoma Et Radix Notopterygii 30, Radix Saposhnikoviae 30, the Radix Angelicae Dahuricae 30, Rhizoma Chuanxiong 30, Herba Pogostemonis 30, Radix Peucedani 30, Fructus Forsythiae 30, Pericarpium Citri Reticulatae 30, Fructus Crataegi 30, Fructus Aurantii Immaturus 30, Fructus Hordei Germinatus (parched) 45, Radix Glycyrrhizae 30, Radix Platycodonis 45, fry Massa Medicata Fermentata 30, Folium Perillae 45, Cortex Magnoliae Officinalis 45, black tea 960; Its noon tea extract 1-50 part, disintegrating agent comprises sour agent 10-30 part, alkaline agent 10-30 part, other adjuvant comprises binding agent 0-15 part, lubricant 0-15 part, sweeting agent 0-10 part, aromatic 0-5 part; It is characterized in that: prepared effervescent tablet profile is annular.
2, effervescence tablet for cold as claimed in claim 1 is characterized in that: the annular of effervescence tablet for cold is made up of some bursts; Be provided with the connecting band of easy fracture between each burst.
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| CNB2005100195208A CN100556401C (en) | 2005-09-30 | 2005-09-30 | Effervescence tablet for cold |
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| CN101558799B (en) * | 2009-05-14 | 2012-02-15 | 杭州六易科技有限公司 | Preparation method for hawthorn digesting green tea tablet |
| CN101558800B (en) * | 2009-05-14 | 2012-02-15 | 杭州六易科技有限公司 | Preparation method for hawthorn digesting black tea tablet |
| CN102228549B (en) * | 2011-06-21 | 2012-09-05 | 刘瑾 | Chinese herbal electuary for treating cold |
| CN102293404A (en) * | 2011-08-31 | 2011-12-28 | 上海交通大学 | Perilla effervescent tablets and preparation method thereof |
| CN103933421A (en) * | 2014-04-10 | 2014-07-23 | 成都中医药大学 | Medicine composition for treating exogenous damp stagnation, dizziness and heaviness and abdominal fullness and distention |
| CN104338062A (en) * | 2014-10-30 | 2015-02-11 | 崔银方 | Chinese medicinal preparation for treating stomachache and diarrhea |
| CN106110093A (en) * | 2016-07-27 | 2016-11-16 | 南京正宽医药科技有限公司 | A kind of wushicha granules and its preparation method and application |
| CN111407808B (en) * | 2020-02-26 | 2022-12-09 | 江苏康缘药业股份有限公司 | Traditional Chinese medicine composition and preparation method and pharmaceutical application thereof |
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| . 中国药典一部. 2000 * |
| 泡腾片研究进展. 罗延红等.西北药学杂志，第16卷第1期. 2001 * |
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