CN102727618B - Application of Caulis et Folium Hedyotis Hedyotideae in preparation of drug or health product for promoting lead removing - Google Patents
Application of Caulis et Folium Hedyotis Hedyotideae in preparation of drug or health product for promoting lead removing Download PDFInfo
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- CN102727618B CN102727618B CN201210231668.8A CN201210231668A CN102727618B CN 102727618 B CN102727618 B CN 102727618B CN 201210231668 A CN201210231668 A CN 201210231668A CN 102727618 B CN102727618 B CN 102727618B
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Abstract
The invention relates to application of Caulis et Folium Hedyotis Hedyotideae in preparation of drug or health product for promoting lead removing. An adoptive technical scheme is as follows: the lead-removing drug or health product is prepared from Caulis et Folium Hedyotis Hedyotideae or decoction thereof individually or in combination with other lead-removing drugs (one or combination of Fructus Lycii, Flos Chrysanthemi, Spora Lygodii, Herba Plantaginis, and Semen Cassiae). According to the invention, Caulis et Folium Hedyotis Hedyotideae with lead removal promoting effect is selected, thereby achieving the aim of relieving or preventing lead damage to human body, and improving symptoms; Caulis et Folium Hedyotis Hedyotideae has no toxic and side effects; and is suitable for long-term administration by population with high blood lead, and is also suitable for children with high blood lead.
Description
Technical field
The present invention relates to the application of Chinese medicine Caulis et Folium hedyotis hedyotideae, is that it is in the purposes of preparing in health product or the medicine that promotes lead-eliminating effect in body specifically.
Background technology
Lead is a Heavy Metallic Elements, it is human body non-essential element, it has very strong affinity to body tissue, and disturb the element of needed by human, upset physiology combination and the proportion relation balance of indispensable element in human body, thereby the physiologically active of enzyme system and biomacromolecule in upset body, makes the interior enzyme system of body lose normal physiological activity and other regulate the regulating action of body function balances to get muddled, and then affects the multiple physiological system functions of human body.
In body, lead content should be zero in theory, but along with Environmental Lead Exposure is on the rise, it directly affects the mankind's health; Lead in environment can enter human body by respiratory tract and skin, and with the formal distribution of phosphoric acid hydrogen lead in whole body, wherein have 90-95% to be converted into orthophosphate and be deposited in skeleton, tooth, internal organs, skin, hair, then transfer to lentamente in blood.The each tissue system of human body is all had to harm, and wherein nerve and hemopoietic system are the most responsive to lead.Concrete clinical manifestation: affect blood lead content rising person's intelligence and skeleton development, form dyspepsia and endocrine disturbance, cause anemia, hypertension and arrhythmia, affect human body kidney merit and immunologic function.
According to international children ' s lead poisoning diagnostic criteria (blood lead value >100ug/L), China's urban children lead poisoning prevalence rate is between 30%-40%, industrial pollution district, urban nearly 100%, even there is no the common urban district of obvious industrial pollution, also there is the children blood lead of 10%-30% to exceed standard.Plumbous to healthy potential hazard, especially the intelligence to child and development impact cause people's attention day by day.
At present, preventing and treating saturnine basic principle is that environment intervention, health education and clinical treatment three combine, and environment intervention is basic, and health education is basic means, and more than alignment degree lead poisoning is just considered Drug therapy.The saturnine medicine of clinical treatment mainly contains calcium disodium chelate (CaNa2EDTA), sodium dimercaptosuccinate (DMSA) etc., though driving lead, these medicines can reduce lead load in body, Plumbum removing is effective, but can make micro elements needed by human run off, also can cause damage to kidney, side effect is larger, and drives nervous lesion that plumbous medicine causes lead and reverse and have little significance, so outside medicine Plumbum removing a good appetite suddenly appearing in a serious disease severe lead poisoning, clinically generally do not adopt.Dietetic therapy or Chinese medicine Plumbum removing gain unanimous acceptance at present, and have obtained certain curative effect, can be used for prevention or treat light, moderate lead poisoning.
Caulis et Folium hedyotis hedyotideae is the stem and leaf of Maguireothamnus speciosus Caulis et Folium hedyotis hedyotideae, and its sweet in the mouth, light is cool in nature, has clearing heat and expelling damp effect; Clinical mainly application aspect clearing away summer-heat removing dampness, yet there are no bibliographical information but whether Caulis et Folium hedyotis hedyotideae has the effect of promotion human body Plumbum removing.
Summary of the invention
The object of the invention is to provide the application of Caulis et Folium hedyotis hedyotideae in the health product of preparation promotion lead-eliminating effect.
The technical solution used in the present invention is: Caulis et Folium hedyotis hedyotideae or its decocting liquid is alone or promote the application in medicine or the health product of lead-eliminating effect in preparation together with other promote lead-eliminating effect medicines.
Above-mentioned application, described other promote lead-eliminating effect medicines to comprise one or more the mixing in Fructus Lycii, Flos Chrysanthemi, Spora Lygodii, Herba Plantaginis or Semen Cassiae.
The present invention adopts Caulis et Folium hedyotis hedyotideae or its decocting liquid as raw material, and formulation method can be prepared into health product or the medicine of peroral dosage form routinely.
The invention has the beneficial effects as follows: the present invention is that screening obtains having the Caulis et Folium hedyotis hedyotideae that promotes lead-eliminating effect from Chinese medicine, can reach and promote the plumbous object of human body being damaged, improved symptom of Plumbum removing, alleviation or prevention, and have no side effect, be suitable for the higher crowd's long-term taking of blood lead, be also suitable for the higher child of blood lead.
The specific embodiment
Below in conjunction with embodiment, the invention will be further elaborated.
embodiment 1
60 of healthy Kunming mouses, clean level, male female half and half, body weight 20 ± 2g, is divided into 5 groups, i.e. and blank group, dyes plumbous model group, 3 dosage groups of high, medium and low Caulis et Folium hedyotis hedyotideae decocting liquid, 12 every group; Lead acetate is dissolved in distilled water by 40mg/kg lumbar injection, sets up mice and dye plumbous animal model.
Caulis et Folium hedyotis hedyotideae decocting liquid adopts conventional decocting method preparation, and decocting liquid various dose group comprises high dose group (10g/kg), middle dosage group (5g/kg), low dose group (2.5g/kg), gastric infusion is respectively organized in medication, and all the other each group gavages the normal saline of equivalent, experiment successive administration totally 6 weeks.After administration finishes, get mice right femoral vein blood 40ul, put into the plastic centrifuge tube with cover that fills 0.36ml1% nitric acid and shake up; Get side 50% femur, after weighing, digest, add rare nitric acid and be settled to 5ml, and get liver and cerebral tissue, carry out blood and bone, liver, brain Determination of Pb with atomic spectrophotometer.Data statistics is checked with T.The results are shown in
Following table 1.
Caulis et Folium hedyotis hedyotideae decocting liquid can reduce and dyes the plumbous regulating liver-QI lead content of plumbous mice blood lead, bone lead, brain, and each dosage group relatively has significant differences with model group on blood lead, bone lead, the plumbous regulating liver-QI lead content of brain
p< 0.01.
embodiment 2
Tested material preparation: equivalent takes Caulis et Folium hedyotis hedyotideae, Flos Chrysanthemi and Spora Lygodii, adopt conventional decocting method preparation, preparation tested material various dose group comprises high dose group (20g/kg), middle dosage group (10g/kg), low dose group (5g/kg), gastric infusion is respectively organized in medication, and all the other each group gavages the normal saline of equivalent, experiment successive administration totally 6 weeks.After administration finishes, get mice right femoral vein blood 40ul, put into the plastic centrifuge tube with cover that fills 0.36ml1% nitric acid and shake up; Get side 50% femur, after weighing, digest, add rare nitric acid and be settled to 5ml, and get liver and cerebral tissue, carry out blood and bone, liver, brain Determination of Pb with atomic spectrophotometer.Data statistics is checked with T.The results are shown in following table 2.
This tested material decocting liquid can reduce and dyes the plumbous regulating liver-QI lead content of plumbous mice blood lead, bone lead, brain, relatively reduces obviously with model group, has significant difference
p< 0.01.
Claims (2)
1. Caulis et Folium hedyotis hedyotideae or its decocting liquid is alone or promote the application in medicine or the health product of lead-eliminating effect in preparation together with other promote lead-eliminating effect medicines, wherein said other promote that lead-eliminating effect medicines are Flos Chrysanthemi and Spora Lygodii.
2. application according to claim 1, is characterized in that: described medicine or health product are peroral dosage form.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210231668.8A CN102727618B (en) | 2012-07-06 | 2012-07-06 | Application of Caulis et Folium Hedyotis Hedyotideae in preparation of drug or health product for promoting lead removing |
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| CN201210231668.8A CN102727618B (en) | 2012-07-06 | 2012-07-06 | Application of Caulis et Folium Hedyotis Hedyotideae in preparation of drug or health product for promoting lead removing |
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| CN102727618A CN102727618A (en) | 2012-10-17 |
| CN102727618B true CN102727618B (en) | 2014-05-21 |
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| CN201210231668.8A Active CN102727618B (en) | 2012-07-06 | 2012-07-06 | Application of Caulis et Folium Hedyotis Hedyotideae in preparation of drug or health product for promoting lead removing |
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Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1456210A (en) * | 2003-01-14 | 2003-11-19 | 江西江中药业股份有限公司 | Products for promoting human lead discharge and preparing method thereof |
| CN1471931A (en) * | 2002-07-30 | 2004-02-04 | 卢存国 | Lead removing preparation |
| CN1513503A (en) * | 2003-08-19 | 2004-07-21 | 湖北龙丹生物医药科技股份有限公司 | Medicinal composition for preventing and treating lead toxication |
| CN1557419A (en) * | 2004-02-09 | 2004-12-29 | 浙江泰利森药业有限公司 | Chinese medicine medlar-Chinese date preparation for promoting lead expel in high blood lead concentration children and its preparing process |
| CN1569164A (en) * | 2004-03-12 | 2005-01-26 | 湖南省儿童医院 | Blood lead content reducing medicine for treating plumbism |
| CN1579481A (en) * | 2004-05-14 | 2005-02-16 | 右江民族医学院 | Medicine for treating fluorine, lead, mercury, arsenic poisoning and its production method |
-
2012
- 2012-07-06 CN CN201210231668.8A patent/CN102727618B/en active Active
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1471931A (en) * | 2002-07-30 | 2004-02-04 | 卢存国 | Lead removing preparation |
| CN1456210A (en) * | 2003-01-14 | 2003-11-19 | 江西江中药业股份有限公司 | Products for promoting human lead discharge and preparing method thereof |
| CN1513503A (en) * | 2003-08-19 | 2004-07-21 | 湖北龙丹生物医药科技股份有限公司 | Medicinal composition for preventing and treating lead toxication |
| CN1557419A (en) * | 2004-02-09 | 2004-12-29 | 浙江泰利森药业有限公司 | Chinese medicine medlar-Chinese date preparation for promoting lead expel in high blood lead concentration children and its preparing process |
| CN1569164A (en) * | 2004-03-12 | 2005-01-26 | 湖南省儿童医院 | Blood lead content reducing medicine for treating plumbism |
| CN1579481A (en) * | 2004-05-14 | 2005-02-16 | 右江民族医学院 | Medicine for treating fluorine, lead, mercury, arsenic poisoning and its production method |
Non-Patent Citations (2)
| Title |
|---|
| 中草药防治铅中毒的研究概况;杨蓉等;《中国医药导报》;20090912;第6卷(第26期);80-81 * |
| 杨蓉等.中草药防治铅中毒的研究概况.《中国医药导报》.2009,第6卷(第26期), |
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