CN1513503A - Medicinal composition for preventing and treating lead toxication - Google Patents
Medicinal composition for preventing and treating lead toxication Download PDFInfo
- Publication number
- CN1513503A CN1513503A CNA031252915A CN03125291A CN1513503A CN 1513503 A CN1513503 A CN 1513503A CN A031252915 A CNA031252915 A CN A031252915A CN 03125291 A CN03125291 A CN 03125291A CN 1513503 A CN1513503 A CN 1513503A
- Authority
- CN
- China
- Prior art keywords
- pharmaceutical composition
- taurine
- lead
- granule
- calcined
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Medicinal Preparation (AREA)
Abstract
A composite medicine in the form of particles for preventing and treating lead poisoning is prepared from wolfberry fruit, galangal fruit, roasted oyster shell and taurine. Its advantages are high curative effect and no toxic by-effect.
Description
Technical field
The present invention relates to the pharmaceutical composition of a kind of treatment and prevention children ' s lead poisoning, particularly a kind of is the pharmaceutical composition with nourishing the liver and kidney, the effect of reduction blood lead that raw material is made with the Chinese herbal medicine.
Background technology
Existing a lot of medicines all have the effect of nourishing the liver and kidney, but the medicine with lead-eliminating effect is not seen any report.Along with development of modern industry, the environment lead contamination is on the rise, and plumbous murder by poisoning to human body is well-known, but the influence of the plumbous Children exposed of low dosage is that medical experts are shocked.The Center for Disease Control allows lead concentration of children to be limited to 0.48 μ Mol/L (10 μ g/dl), and internationally recognized danger level is 250 μ g/L.Show about 93% blood lead of the cities and towns child who lives in the industrial occupancy greater than 0.48 μ Mol/L according to domestic preliminary epidemiology, studies show that of Shanghai has 33% urban district children blood lead value above internationally recognized danger level; 1 routine excessive Plumbum absorption is just arranged among per 3 children.Further research also shows, too high blood lead has produced extremely harmful effect to youngster heavy growth promoter, especially intellectual development.Discover that its average IQ of child that blood lead has surpassed 250 μ g/L is than low about 10 minutes of the low person of blood lead, the too high child of blood lead aspect Physique growth and psychological aspects harmful effect is all arranged.The clinical symptoms that shows is: intelligence that kidney deficiency shows and physical dysplasia, children's often occurs that simulation learning difficulty, spatial synthesis ability drop, many moving, inflammable, aprosexia, aggressive increase, IQ decline, and degradation under total perception, linguistic competence, quantitation capabilities and the memory ability, slow, poor, the immunologic hypofunction of body constitution of anthropometic in addition.Study consistent the confirmation both at home and abroad, plumbous influence to the higher nerve function, the particularly influence of infant function and remote effect, as if do not have concentration limit can stipulate, and influence can not be returned contrary, promptly in case generation then has been difficult to reverse, therefore prevention has more important, more positive meaning than treating.The most basic preventive measure is to eliminate environmental pollution or break away from lead contamination environment (I and II prevention), this is huge system's social engineering, can't accomplish according to domestic present circumstances, unique preventive measure that can realize is to employing prevention property of high risk child administration (tertiary prevention) under the existence conditions, to strengthen its resistivity to Toxicity of Lead, eliminate or alleviate the harmful effect that the child is caused, the present invention is based on this background and basic thought.
Summary of the invention
Purpose of the present invention provides a kind of pharmaceutical composition that has nourishing the liver and kidney, reduces the blood lead effect.This pharmaceutical composition by nourishing the liver and kidney, strong shape muscles and bones, reduce blood lead and play and increase intelligence, physical strength reinforcing, promotion upgrowth and development of children.Evident in efficacy, nontoxic through experiment and this pharmaceutical composition of clinical research confirmation, have no side effect, be treatment and the good medicine that prevents children ' s lead poisoning.
Medicament of the present invention is to be made by weight ratio by following substances:
Fructus Lycii 800-1200g Fructus Alpiniae Oxyphyllae 400-600g
Concha Ostreae (calcined) 160-240g taurine 200-300g
Above-mentioned substance preferred weight proportioning is as follows:
Fructus Lycii 900-1100g Fructus Alpiniae Oxyphyllae 450-550g
Concha Ostreae (calcined) 180-220g taurine 225-275g
Above-mentioned substance preferred weight proportioning is as follows:
Fructus Lycii 1000g Fructus Alpiniae Oxyphyllae 500g
Concha Ostreae (calcined) 200g taurine 250g
Aforementioned pharmaceutical compositions can be prepared into any pharmaceutical dosage form in capsule, tablet, extractum, pill, oral liquid, granule, syrup, the powder according to the practice of pharmacy of routine.
This pharmaceutical composition has nourishing the liver and kidney, reduces the blood lead effect, is used for the treatment of and prevents children ' s lead poisoning.
Preparation technology's flow process of medicinal granule of the present invention is:
A, with the Fructus Alpiniae Oxyphyllae water at atmospheric pressure distill Fructus Alpiniae Oxyphyllae volatile oil, in addition device is preserved; Medicinal residues are standby;
B, Fructus Lycii, Fructus Alpiniae Oxyphyllae medicinal residues merge and decoct three times, and each 1.5 hours, the decocting with 1.5 times of amounts of medical material boiled at every turn, refilters, and merges three times filtrate, concentrated filtrate, and spray drying again must extract powder;
C, weighing: take by weighing the real weighing of Fructus Lycii, Fructus Alpiniae Oxyphyllae mixing dry extract and the real weighing of taurine and Concha Ostreae (calcined) (the real weighing of dry extract=crude drug recipe quantity * yield, the real weighing of taurine and Concha Ostreae (calcined)=recipe quantity ÷ purity),
D granulates: in the input wet mixing pelletizer, stirring at low speed 120 seconds is opened granulation cutting knife low or first gear, adds 95% an amount of ethanol wetting agent simultaneously, granulates, and gets soft material, receives soft material in 68-70 ℃, constant pressure and dry 110-130 minute, gets dried material; Pulverize with 120 mesh sieves when dried material is cooled to room temperature, get comminuting matter; Comminuting matter is dropped in the wet mixing pelletizer, and stirring at low speed 120 seconds is opened granulation cutting knife low or first gear, adds 80% an amount of ethanol wetting agent simultaneously, granulates, and gets soft material; Soft material is granulated once with 16 order stainless steel meshs on oscillating granulator, granule behind the granulate; Granule behind the granulate and an amount of essence, stevioside are sucked in the V-type high efficient mixed machine, evenly spray into the Fructus Alpiniae Oxyphyllae volatile oil solution simultaneously,, always mixed 15 minutes, get finished particle, be packed as 5 gram/bags, wherein contain crude drug 1.95g if any utilizing material to suck in the lump.
According to the theory of Chinese medical science the kidney invigorating is basic, and the kidney being the origin of congenital constitution, the kidney generating marrow and dominating bone, and again because of kidney storing essence, it is clever that smart foot then makes us wisdom, kidney governing bones, but also bone strengthening of the kidney invigorating.Pharmaceutical composition of the present invention passes through nourishing the liver and kidney just, strong muscles and bones, reduce blood lead and come nootropics, physical strength reinforcing, promote youngster's long hair of living again to educate, intelligence core has the effect of warming spleen and tonifying kidney in the prescription, indirect supply calcium preparation, and calcium and lead belong to divalent metal element together, the competition effect is arranged in the metabolic process in vivo, Concha Ostreae (calcined) has the heat clearing away nourishing YIN, the suppressing the hyperactive YANG for relieving convulsion effect, and the same delivery of competition is conjugated protein in small intestinal, the supply of calcium also suppresses plumbous toxicity, Fructus Lycii is sweet flat with nourishing the liver and kidney in the prescription, and the toxicity of lead is had tangible antagonism, can be used for reducing plumbous inhibitory action to immunologic function.Taurine is the necessary aminoacid of a kind of condition, has physiologically active widely, and animal experiment proof taurine is to the child, and special neonate nervous system and audition are grown important effect is all arranged, and have become a kind of additive that increases the intelligence product at present.
With medicinal granule of the present invention is that the sub-granule of intelligence is to the rat long term toxicity test, its concrete condition is: adopt 3 dosage groups to amount to crude drug 16.75g/kg, 33.5g/kg and 67g/kg, be equivalent to 12.5,25 and 50 times of the clinical consumption of people, learn aspects such as inspection and histopathological examination from growth of animal, organ coefficient mensuration, blood test, uroscopy, blood biochemical, the result does not find that medicinal granule of the present invention has tangible toxicity to produce to animal.Specifically see below attached one: " the sub-granule rat of intelligence long term toxicity test ".
With medicinal granule of the present invention its mouse oral acute toxicity is tested, its concrete condition is: get 20 of Kunming mouses, male and female half and half, body weight 18-22g, after the fasting 16 hours, press the administration of 20g/kg body weight, observe the mice response situation at once, rarely seen mice reposes, discomfort is arranged slightly, full recovery is normal after half an hour, and continuous seven days, the weight of animals increased, ordinary circumstance is good, do not see death, its dosage behaviour consumption per day 150mg/kg 100 surplus times, the experiment show that this medicinal granule is to its mouse oral acute toxicity LD
50＞20g/kg body weight.Can think medicinal granule this to people's avirulence.Specifically see below Annex II: " the sub-granule its mouse oral of intelligence acute toxicity test report ", " acute toxicity test report in the sub-granule rat warp of intelligence ".
The main pharmacodynamics of this medicinal granule by test, confirms that this medicine can effectively reduce the mice Pb-B, improves ability of learning and memory, and saturnine preventive protection effect is better than each prescription solely use or other proportioning mode.Specifically see below Annex III: " research of the sub-granule of intelligence main pharmacodynamics ".
The clinical trial of this medicinal granule, its concrete condition is: select totally 399 of sons and younger brothers primary school of Nanjing Steel ﹠ Iron Plant two, tertions, carrying out blood lead measures, wherein there are 162 blood lead concentrations to be higher than 20 μ g/dl, 81 of boys, 81 of young girls took this medicinal granule one month, and blood lead concentration obviously descends.X=27.63 μ g/dl before the medication, X=14.56 μ g/dl after the medication reduces closely 50%, illustrates that this medicinal granule dropping blood lead curative effect is obvious, and its effective percentage reaches 94.1%, and the yellowish complexion body is thin to improving, also there is positive effect the sleep aspect.Specifically see below Annex IV: " the sub-granule clinical verification of intelligence brief summary ".
Medicinal granule of the present invention is applicable to child's caused by liver and kidney deficiency disease, and it is weak, stupid, weak to have muscle power, and diet is few, and is dizzy, vision is weak, pulse condition is thin or disease such as thin and delicate, thin white fur of tongue, can treat, and can prevent again.1 month was 1 course of treatment, can obey the 3-5 course of treatment.
Instructions about how to take medicine, dosage: oral.Below 3 years old, each 2.5 grams, every day 1 time; 3-8 year, each 5 grams (bag), every day 1 time; 9-15 year, each 5 grams (bag), every day 2 times.All use an amount of warm water delivery service.Attention: during if any diseases such as fever caused by exogenous pathogens, coughs, should not take.
The specific embodiment
Embodiment
Take by weighing raw material by following proportioning:
Fructus Lycii 1000g Fructus Alpiniae Oxyphyllae 500g Concha Ostreae (calcined) 200g taurine 250g
Production method is as follows:
By the consumption in the above-mentioned prescription, get Fructus Alpiniae Oxyphyllae and add the water air-distillation and get Fructus Alpiniae Oxyphyllae volatile oil, device is preserved in addition; The decocting that medicinal residues and Fructus Lycii add 1.5 times of amounts boils three times, and each 1.5 hours, collecting decoction filtered, concentrated filtrate, and spray drying gets extract powder again; Add Concha Ostreae (calcined), taurine and the adjuvant of recipe quantity, mixing is made granule, and drying adds Fructus Alpiniae Oxyphyllae volatile oil, and mixing gets finished particle, is packed as 5 gram/bags.
Claims (6)
1, a kind of pharmaceutical composition with treatment and prevention children ' s lead poisoning, make by weight ratio by following substances:
Fructus Lycii 800-1200g Fructus Alpiniae Oxyphyllae 400-600g
Concha Ostreae (calcined) 160-240g taurine 200-300g
2,, it is characterized in that above-mentioned substance preferred weight proportioning is as follows according to the described pharmaceutical composition of claim 1:
Fructus Lycii 900-1100g Fructus Alpiniae Oxyphyllae 450-550g
Concha Ostreae (calcined) 180-220g taurine 225-275g
3,, it is characterized in that above-mentioned substance preferred weight proportioning is as follows according to the described pharmaceutical composition of claim 1:
Fructus Lycii 1000g Fructus Alpiniae Oxyphyllae 500g
Concha Ostreae (calcined) 200g taurine 250g
4, according to claim 1,2 or 3 described pharmaceutical compositions, it is characterized in that aforementioned pharmaceutical compositions, can be prepared into any pharmaceutical dosage form in capsule, tablet, pill, oral liquid, granule, extractum, syrup, the powder according to the practice of pharmacy of routine.
5, pharmaceutical composition according to claim 4 is characterized in that said pharmaceutical composition is a granule.
6,, it is characterized in that this pharmaceutical composition has nourishing the liver and kidney, reduces the blood lead effect, has the purposes of treatment and prevention children ' s lead poisoning according to the described pharmaceutical composition of claim 1.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA031252915A CN1513503A (en) | 2003-08-19 | 2003-08-19 | Medicinal composition for preventing and treating lead toxication |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA031252915A CN1513503A (en) | 2003-08-19 | 2003-08-19 | Medicinal composition for preventing and treating lead toxication |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1513503A true CN1513503A (en) | 2004-07-21 |
Family
ID=34239581
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA031252915A Pending CN1513503A (en) | 2003-08-19 | 2003-08-19 | Medicinal composition for preventing and treating lead toxication |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1513503A (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102727618A (en) * | 2012-07-06 | 2012-10-17 | 辽宁大学 | Application of Caulis et Folium Hedyotis Hedyotideae in preparation of drug or health product for promoting lead removing |
| CN104666912A (en) * | 2015-02-11 | 2015-06-03 | 郭如英 | Medicament with capabilities of dispelling wind, dredging collaterals and improving intelligence for patient with intelligence impairment and preparation of medicament |
| CN105935422A (en) * | 2016-05-10 | 2016-09-14 | 浙江省中医院 | Traditional Chinese medicinal composition and application thereof in preparation of blood lead reducing medicines |
| CN106620468A (en) * | 2016-10-18 | 2017-05-10 | 广东医科大学 | Composition for promoting excretion of lead and preparation method thereof |
-
2003
- 2003-08-19 CN CNA031252915A patent/CN1513503A/en active Pending
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102727618A (en) * | 2012-07-06 | 2012-10-17 | 辽宁大学 | Application of Caulis et Folium Hedyotis Hedyotideae in preparation of drug or health product for promoting lead removing |
| CN102727618B (en) * | 2012-07-06 | 2014-05-21 | 辽宁大学 | Application of Caulis et Folium Hedyotis Hedyotideae in preparation of drug or health product for promoting lead removing |
| CN104666912A (en) * | 2015-02-11 | 2015-06-03 | 郭如英 | Medicament with capabilities of dispelling wind, dredging collaterals and improving intelligence for patient with intelligence impairment and preparation of medicament |
| CN105935422A (en) * | 2016-05-10 | 2016-09-14 | 浙江省中医院 | Traditional Chinese medicinal composition and application thereof in preparation of blood lead reducing medicines |
| CN105935422B (en) * | 2016-05-10 | 2020-01-14 | 浙江省中医院 | Traditional Chinese medicine composition and application thereof in preparation of blood lead reducing medicine |
| CN106620468A (en) * | 2016-10-18 | 2017-05-10 | 广东医科大学 | Composition for promoting excretion of lead and preparation method thereof |
| CN106620468B (en) * | 2016-10-18 | 2020-10-27 | 广东医科大学 | Composition for promoting lead discharge and preparation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101601827B (en) | Traditional Chinese medicine for preventing and/or treating dry syndrome and slowing down aging and preparation method thereof | |
| CN101972462A (en) | Alcohol-relieving healthcare product | |
| CN105105116A (en) | Health food with effects of relieving physical fatigue and enhancing immunity and preparation method of health food | |
| CN104127758A (en) | Traditional Chinese medicinal composition having spleen invigorating and stomach nourishing efficacies, and preparation method and application thereof | |
| CN104940645A (en) | Dendrobium officinale traditional Chinese medicine composition with functions of maintaining beauty and keeping young and preparation of dendrobium officinale traditional Chinese medicine composition | |
| CN104013733B (en) | Chitosan composition for prevention and treatment of chemical liver injury and preparation method thereof | |
| CN104544047B (en) | A kind of former orange taste sodium ascorbate buccal tablet and preparation technology thereof | |
| CN109170476A (en) | Health food containing witloof | |
| CN105663204A (en) | Composition and preparation capable of improving immune function, resisting fatigue and treating cold as well as preparation method and application of composition | |
| CN1513503A (en) | Medicinal composition for preventing and treating lead toxication | |
| CN106511740A (en) | Radix ginseng-containing health product and preparation method therefor | |
| CN109453317A (en) | A kind of anaesthetic and its preparation process for strengthening by means of tonics | |
| CN100438902C (en) | Medicine for preventing and controlling chicken's infectious rhinitis | |
| CN103584092A (en) | Health-care composition | |
| CN103238711A (en) | Food healthcare tea granules for promoting lead excreting | |
| CN107233491A (en) | It is a kind of to improve the antifatigue maca composition of energy | |
| CN102885884B (en) | Granule for treating poultry bacterial diseases and method for preparing granule | |
| CN101797353A (en) | Plant SOD composite body-building tablet (pill) and preparation method thereof | |
| CN109078089A (en) | A kind of anti-aging, the Chinese medicine composition and its preparation for preventing and treating osteoporosis | |
| CN101991659A (en) | Preparation with functions of clearing heat and releasing toxin and preparation method | |
| CN109349382A (en) | A kind of health care preparation with except the cold simultaneous weight-reducing health-preserving function of cold solution | |
| CN108669530A (en) | A kind of Hericium erinaceus composition, tablet and preparation method conducive to stomach health | |
| CN104435555B (en) | A kind of Chinese medicinal granular formulation containing Concha Ostreae Rhizoma Dioscoreae and preparation method thereof | |
| CN1062470C (en) | Chinese medicine prepn for infant anorexia | |
| CN102091135A (en) | Bezoar antidotal pills (tables and capsules) containing bezoar cultured in vitro and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |