CN106074305A - A kind of Noni fruit toothpaste with oral mucosa protective effect and preparation method thereof - Google Patents
A kind of Noni fruit toothpaste with oral mucosa protective effect and preparation method thereof Download PDFInfo
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/738—Cyclodextrins
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- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/602—Glycosides, e.g. rutin
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/731—Cellulose; Quaternized cellulose derivatives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/736—Chitin; Chitosan; Derivatives thereof
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- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
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- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
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Abstract
The invention belongs to daily necessities field, be specifically related to a kind of Noni fruit toothpaste with oral mucosa protective effect and preparation method thereof.The Noni fruit toothpaste with oral mucosa protective effect that the present invention provides comprises glucityl beta cyclodextrin clathrate; described glucityl beta cyclodextrin clathrate comprises Noni fruit mixture and glucityl beta cyclodextrin, and described Noni fruit mixture is made up of Noni extract, ethyl cellulose and Macrogol 4000.The Noni fruit toothpaste with oral mucosa protective effect that the present invention provides has significant bactericidal action, can effectively reduce the pain of oral ulcer patient, shortens the healing time of oral ulcer, has significant protective effect to oral mucosa.And the Noni fruit toothpaste with oral mucosa protective effect that the present invention provides has that moisture retention is good, stablize high advantage, is a kind of ideal toothpaste.
Description
Technical field
The invention belongs to daily necessities field, be specifically related to a kind of Noni fruit toothpaste with oral mucosa protective effect and
Preparation method.
Background technology
Toothpaste is for cleaning tooth, the articles for daily use of protection oral hygiene health.It is to improve on the basis of dentifrice
Being formed, dentifrice in early days is by forming as surfactant using calcium carbonate as abrasivus with using soap.Along with science and technology
Development, toothpaste industry is developed the most rapidly, the development and application of new abrasivus, thickening agent and surfactant, makes tooth
Cream product constantly upgrades.
At present, there is various toothpaste on the market, such as: toothpaste with fluoride, Chinese herbal toothpaste, inflammation-diminishing toothpaste, hypo-allergenic
Toothpaste and de-sludging whitening toothpaste etc..Toothpaste with fluoride is to be added in toothpaste by appropriate fluoride, can increase oral cavity partial
Fluorine, forms strong protective layer at dental surface, thus reduces the generation of dental caries, and fluorine can also improve the anti-corruption of tooth
Erosion ability, suppresses the growth and breeding of cariogenic antibacterial, can preferably take care of one's teeth.But long-term Excess free enthalpy fluorine can cause body
Chronic poisoning, affect the sclerous tissues of human body, including tooth, skeleton, some other soft tissue also had damage, the most also can draw
Play dental fluorosis and skeletal fluorosis.
Chinese herbal toothpaste is to add some Chinese herbal medicine on the basis of ordinary toothpaste, and it has heat-clearing and toxic substances removing, anti-inflammation hemostasia
Effect, to alleviate gingivitis have certain assosting effect.But owing to Chinese herbal medicine onset time length, content are many, cause effect
The most inconspicuous.Allergy-free toothpaste is to add the desensitization composition such as potassium nitrate or strontium chloride in toothpaste, has dentin hypersensitiveness necessarily
Mitigation, but potassium nitrate or strontium chloride are harmful, are unfavorable for life-time service.Therefore, cleaning is researched and developed out
The toothpaste that effect is notable, safety is high is still the problem currently needing solution badly.
Chinese patent CN103417402B discloses a kind of Bactericidal azulene toothpaste, and described Bactericidal azulene toothpaste is by Flos Chrysanthemi
Ring, aluminium hydroxide, sodium lauroamphopg-acetate phosphate, guar gum, Pyrusussuriensis alcohol and water form.This Bactericidal azulene
Toothpaste has foaming abundancy, sterilizing power by force, and energy total care oral cavity, protection oral cavity and the advantage of dental health, be that one meets
The sterilization toothpaste that modern requires.
Chinese patent CN103417400B discloses a kind of toothpaste containing vinegar, and described toothpaste containing vinegar is by glacial acetic acid, calcium carbonate, the moon
Osmanthus acyl both sexes base PG-acetate sodium phosphate, hydroxyethyl cellulose, Pyrusussuriensis alcohol and water form.This toothpaste containing vinegar has antiinflammatory, takes off
The multi-efficiencies such as quick, antihalitosis, removing smoke spots, energy total care oral cavity, protection oral cavity and dental health.
Chinese patent application 201510711524.6 discloses a kind of chitin tooth-caring toothpaste, described chitin tooth-caring toothpaste
Main by chitin, sorbitol sugar liquid, silicon dioxide, sodium lauryl sulphate, sodium carboxymethyl cellulose, deionized water, saccharin
Sodium, Mentholum, Flos Caryophylli, nipalgin fat composition, the chitin tooth-caring toothpaste prepared is except having ordinary toothpaste cleaning oral cavity
Outside function, have more anti-treating dental ulcer, gingival swelling and pain, the effect such as hemorrhage, wherein containing-OH and NH in chitin molecule2+Polarity
Group, can effectively suppress the breeding of oral cavity harmful bacteria, the growth of propagation probiotics, improve internal environment of oral cavity, and chitin is exclusive
Trophic factors and functional factor, there is the strongest biocompatibility and film forming ability, effectively protection gingiva and the flank of tooth is not invaded
Erosion, protects oral cavity comprehensively.
But, current toothpaste there is also in storage process that dehydration is very fast, moisture-retaining capacity is low and the shortcoming of poor stability,
Still can not meet modern Man's Demands.
Summary of the invention
In order to solve in prior art toothpaste problem present in the storage process, it is an object of the invention to provide one
Noni fruit toothpaste with oral mucosa protective effect and preparation method thereof, to solve the problems referred to above.What the present invention provided has
The Noni fruit toothpaste of oral mucosa protective effect has significant protective effect to oral mucosa, and this Noni fruit toothpaste also has
Having moisture retention and frost resistance good, safety is high, and the advantage that stability is high, is a kind of ideal health type toothpaste.
The invention provides a kind of Noni fruit toothpaste with oral mucosa protective effect, described Noni fruit toothpaste includes Portugal
Glycosyl-beta-cyclodexterin clathrate, described glucityl-Benexate Hydrochloride comprises Noni fruit mixture and glucityl-β-ring is stuck with paste
Essence, described Noni fruit mixture is made up of Noni extract, ethyl cellulose and Macrogol 4000.
Further, described glucityl-Benexate Hydrochloride addition in Noni fruit toothpaste is 1-15%, described
Glucityl-Benexate Hydrochloride preferred addition in Noni fruit toothpaste is 10%.
Further, the preparation method of described glucityl-Benexate Hydrochloride is:
Fresh Noni fruit is cleaned by S1, section, places under conditions of temperature is 35-45 DEG C and dry, pulverize 80-100 mesh
Sieve, obtains fine powder；The ethanol solution that 6-8 times of volume fraction is 55-65% of above-mentioned fine powder gross weight, ultrasound wave is added in fine powder
Extract 25-35min, filter, obtain filtrate I；Then it is the second of 65-75% toward filtering residue adds 6-8 times of volume fraction of above-mentioned filtering residue
Alcoholic solution, ultrasonic extraction 20-30min, filters, filtrate II；Merging filtrate, reclaims ethanol dense under the conditions of temperature is 60 DEG C
Contracting, obtains Noni extract；
The Noni extract that step S1 is obtained by S2 is mixed homogeneously with ethyl cellulose and Macrogol 4000, obtains promise
Beautiful fruit mixture；
S3 adds water toward glucose group-beta-cyclodextrin, is configured to glucose group-beta-cyclodextrin saturated aqueous solution；
The Noni fruit mixture that step S2 is obtained by S4 adds the glucose group-beta-cyclodextrin saturated aqueous solution that step S3 obtains
In, under conditions of temperature is 35-60 DEG C, stirs 2-5h, filters, filtering residue is dried under the conditions of 60 DEG C, cross 80 mesh sieves, through P2O5
It is dried, obtains glucityl-Benexate Hydrochloride.
Further, Noni extract and ethyl cellulose and Macrogol 4000 2-in mass ratio in described step S2
4:1-3:3-5 mixes；In described step S4, Noni fruit mixture is carried out with glucose group-beta-cyclodextrin 1:2-6 in mass ratio
Mixing.
Further, Noni extract and ethyl cellulose and Macrogol 4000 in mass ratio 3 in described step S2:
2:4 mixes；In described step S4, Noni fruit mixture mixes with glucose group-beta-cyclodextrin 1:5 in mass ratio.
Further, described Noni fruit toothpaste also includes following components:
40-60% calcium carbonate, 18-40% wetting agent, 4-8% binding agent, 2-4% sodium lauryl sulfate, 0.1-0.4% sugar
Essence sodium, 0.8-1.5% essence, 0.1-0.5% sorbic acid and 1-2% deionized water.
Further, described Noni fruit toothpaste also includes following components:
47.3% calcium carbonate, 30% wetting agent, 6% binding agent, 3% sodium lauryl sulfate, 0.2% saccharin sodium, 1.2% perfume
Essence, 0.3% sorbic acid and 2% deionized water.
Further, described wetting agent is by sorbitol, Polyethylene Glycol and oligochitosan 2-4:1-3:0.5-1 group by weight
Become；Described binding agent is made up of by weight 4-6:1-3 Carboxymethyl cellulose sodium and lauryl glucoside.
Further, described wetting agent is made up of by weight 3:2:0.8 sorbitol, Polyethylene Glycol and oligochitosan；Described
Binding agent is made up of by weight 5:2 Carboxymethyl cellulose sodium and lauryl glucoside.
It addition, present invention also offers the preparation method of a kind of Noni fruit toothpaste with oral mucosa protective effect, bag
Include following steps:
S1 by calcium carbonate, wetting agent, binding agent, sodium lauryl sulfate, saccharin sodium, sorbic acid and deionized water in vacuum
For stirring under conditions of-0.08Mpa～0.10Mpa, obtain mixture；
Essence and glucityl-Benexate Hydrochloride is added in the mixture that step S1 obtains by S2, vacuum be-
Stir under conditions of 0.08Mpa～0.10Mpa, to obtain final product.
Glucityl-beta-cyclodextrin inclusion compound Noni fruit mixture that the present invention uses adds in toothpaste, can effectively increase
The dissolubility of strong Noni extract, improves bioavailability and the stability of Noni extract.Find through test, the present invention
The Noni fruit toothpaste with oral mucosa protective effect provided has significant bactericidal action, and it is to colibacillary sterilizing rate
More than 99.08%, the sterilizing rate of staphylococcus aureus is more than 99.10%, the sterilizing rate of Candida albicans is more than
99.12%, the sterilizing rate of Streptococcus mutans is more than 99.16%, the sterilizing rate of porphyromonas gingivalis is more than 98.04%.
Escherichia coli, staphylococcus aureus, white are read by the Noni fruit toothpaste with oral mucosa protective effect that the present invention provides
Coccus, Streptococcus mutans and porphyromonas gingivalis have significant bactericidal action, to oral mucosa, recurrent oral ulceration more
Close, suppression dental plaque, alleviate gingivitis there is preferably protection and therapeutical effect.
Further, finding through test, the Noni fruit toothpaste with oral mucosa protective effect that the present invention provides is permissible
Significantly (P ＜ 0.05) reduces the pain of oral ulcer patient, shortens the ulcer time of oral ulcer patient, to oral ulcer
There is significant therapeutic effect, oral cavity is had more significant protective effect simultaneously.
Further, the moisturizing being made up of by certain weight ratio sorbitol, Polyethylene Glycol and oligochitosan that the present invention provides
Agent has significant moistening effect, and oligochitosan can solve to cause toothpaste to stablize poor lacking owing to sorbitol water content is high
Fall into.Finding through test, the Noni fruit toothpaste with oral mucosa protective effect that the present invention provides is 20 DEG C in temperature, the wettest
Under conditions of degree is 54%, fluid loss during 48h is less than 5.8%, illustrate that the present invention provides by sorbitol, Polyethylene Glycol and shell
The wetting agent of certain weight ratio composition pressed by oligosaccharide mutually coordinated can act the effect strengthening moisturizing.
Further, what the present invention provided is made up of by constant weight Carboxymethyl cellulose sodium and lauryl glucoside
Binding agent has the advantage that adhesiveness is strong and stability is high, and lauryl glucoside can effectively solve hydroxylmethyl cellulose
Water outlet, anti-thick, mastic matt appearance, the defect of viscous mouth of brushing teeth easily is there is in element sodium in the storage process of toothpaste.Send out through test
Existing, the viscosity of the Noni fruit toothpaste with oral mucosa protective effect that the present invention provides rate of change over time is less,
When 90 days, its viscosity is more than 13Pa s, illustrate that the present invention provides by Carboxymethyl cellulose sodium and lauryl glucoside by one
Determine the binding agent of weight composition to have interacted the enhancing viscosity of toothpaste and the effect of stability, can effectively extend toothpaste
Shelf-life.
Compared with prior art, the Noni fruit toothpaste with oral mucosa protective effect that the present invention provides has following excellent
Gesture:
(1) the Noni fruit toothpaste with oral mucosa protective effect that the present invention provides has significant bactericidal action, can
With the effective pain reducing oral ulcer patient, shorten the healing time of oral ulcer, oral cavity is had significantly protection
Effect；
(2) the Noni fruit toothpaste with oral mucosa protective effect that the present invention provides has moisture retention and frost resistance is good,
Safety is high, and the advantage that stability is high, is a kind of ideal health type toothpaste.
Detailed description of the invention
Below by way of the description of detailed description of the invention, the invention will be further described, but this is not the limit to the present invention
System, those skilled in the art are according to the basic thought of the present invention, and various modifications may be made or improves, but without departing from this
The basic thought of invention, the most within the scope of the present invention.
Embodiment 1, the preparation of a kind of glucityl-Benexate Hydrochloride
Fresh Noni fruit is cleaned by S1, section, places under conditions of temperature is 35 DEG C and dry, pulverize 80 mesh sieves, obtains carefully
Powder；The 6 times of volume fractions adding above-mentioned fine powder gross weight in fine powder are the ethanol solution of 55%, ultrasonic extraction 25min, mistake
Filter, obtains filtrate I；Then it is the ethanol solution of 65% toward filtering residue adds 6 times of volume fractions of above-mentioned filtering residue, ultrasonic extraction
20min, filters, filtrate II；Merging filtrate, reclaims ethanol under the conditions of temperature is 60 DEG C and concentrates, obtaining Noni extract；
The Noni extract that step S1 is obtained by S2 is mixed homogeneously with ethyl cellulose and Macrogol 4000, described promise
Beautiful berry extract mixes with ethyl cellulose and Macrogol 4000 2:1:5 in mass ratio, obtains Noni fruit mixture；
S3 adds water toward glucose group-beta-cyclodextrin, is configured to glucose group-beta-cyclodextrin saturated aqueous solution；
The Noni fruit mixture that step S2 is obtained by S4 adds the glucose group-beta-cyclodextrin saturated aqueous solution that step S3 obtains
In, in described step S4, Noni fruit mixture mixes with glucose group-beta-cyclodextrin 1:4 in mass ratio, in temperature is
Stir 3h under conditions of 35 DEG C, filter, filtering residue is dried under the conditions of 60 DEG C, cross 80 mesh sieves, through P2O5Be dried, obtain glucityl-β-
Cyclodextrin clathrate.
Embodiment 2, the preparation of a kind of glucityl-Benexate Hydrochloride
Fresh Noni fruit is cleaned by S1, section, places under conditions of temperature is 40 DEG C and dry, pulverize 100 mesh sieves, obtains carefully
Powder；The 8 times of volume fractions adding above-mentioned fine powder gross weight in fine powder are the ethanol solution of 60%, ultrasonic extraction 30min, mistake
Filter, obtains filtrate I；Then it is the ethanol solution of 70% toward filtering residue adds 8 times of volume fractions of above-mentioned filtering residue, ultrasonic extraction
25min, filters, filtrate II；Merging filtrate, reclaims ethanol under the conditions of temperature is 60 DEG C and concentrates, obtaining Noni extract；
The Noni extract that step S1 is obtained by S2 is mixed homogeneously with ethyl cellulose and Macrogol 4000, described promise
Beautiful berry extract mixes with ethyl cellulose and Macrogol 4000 3:2:4 in mass ratio, obtains Noni fruit mixture；
S3 adds water toward glucose group-beta-cyclodextrin, is configured to glucose group-beta-cyclodextrin saturated aqueous solution；
The Noni fruit mixture that step S2 is obtained by S4 adds the glucose group-beta-cyclodextrin saturated aqueous solution that step S3 obtains
In, described Noni fruit mixture mixes with glucose group-beta-cyclodextrin 1:5 in mass ratio, under conditions of temperature is 55 DEG C
Stirring 4h, filters, and is dried by filtering residue under the conditions of 60 DEG C, crosses 80 mesh sieves, through P2O5It is dried, obtains glucityl-beta-cyclodextrin inclusion compound
Thing.
Embodiment 3, a kind of Noni fruit toothpaste with oral mucosa protective effect
The described Noni fruit toothpaste with oral mucosa protective effect is composed of the following components:
6% glucityl-Benexate Hydrochloride, 55.6% calcium carbonate, 22% wetting agent, 8% binding agent, 4% lauryl alcohol
Sodium sulfate, 0.4% saccharin sodium, 1.5% essence, 0.5% sorbic acid and 2% deionized water；Described wetting agent is by sorbitol, poly-second
Glycol and oligochitosan form by weight 2:3:1；Described binding agent is pressed weight by Carboxymethyl cellulose sodium and lauryl glucoside
Measure and form than 4:3.
Preparation method:
S1 by calcium carbonate, wetting agent, binding agent, sodium lauryl sulfate, saccharin sodium, sorbic acid and deionized water in vacuum
For stirring under conditions of-0.08Mpa, obtain mixture；
Essence and glucityl-Benexate Hydrochloride is added in the mixture that step S1 obtains by S2, vacuum be-
Stir under conditions of 0.08Mpa, to obtain final product.
Embodiment 4, a kind of Noni fruit toothpaste with oral mucosa protective effect
The described Noni fruit toothpaste with oral mucosa protective effect is composed of the following components:
10% glucityl-Benexate Hydrochloride, 47.3% calcium carbonate, 30% wetting agent, 6% binding agent, 3% lauryl alcohol
Sodium sulfate, 0.2% saccharin sodium, 1.2% essence, 0.3% sorbic acid and 2% deionized water；Described wetting agent is by sorbitol, poly-second
Glycol and oligochitosan form by weight 3:2:0.8；Described binding agent is pressed by Carboxymethyl cellulose sodium and lauryl glucoside
Weight ratio 5:2 forms.
Preparation method is similar to Example 3.
Embodiment 5, a kind of Noni fruit toothpaste with oral mucosa protective effect
The described Noni fruit toothpaste with oral mucosa protective effect is composed of the following components:
15% glucityl-Benexate Hydrochloride, 40.8% calcium carbonate, 36% wetting agent, 4% binding agent, 2% lauryl alcohol
Sodium sulfate, 0.2% saccharin sodium, 0.8% essence, 0.2% sorbic acid and 1% deionized water；Described wetting agent is by sorbitol, poly-second
Glycol and oligochitosan form by weight 4:1:0.5；Described binding agent is pressed by Carboxymethyl cellulose sodium and lauryl glucoside
Weight ratio 6:1 forms.
Preparation method is similar to Example 3.
Comparative example 1, a kind of Noni fruit toothpaste with oral mucosa protective effect
The described Noni fruit toothpaste with oral mucosa protective effect is composed of the following components:
10% glucityl-Benexate Hydrochloride, 47.3% calcium carbonate, 30% wetting agent, 6% binding agent, 3% lauryl alcohol
Sodium sulfate, 0.2% saccharin sodium, 1.2% essence, 0.3% sorbic acid and 2% deionized water；Described wetting agent is by sorbitol and gathers
Ethylene glycol forms by weight 1:1；Described binding agent is by Carboxymethyl cellulose sodium and lauryl glucoside 5:2 group by weight
Become.
Preparation method is similar to Example 3.
Difference with embodiment 4 is, described wetting agent is made up of by weight 1:1 sorbitol and Polyethylene Glycol.
Comparative example 2, a kind of Noni fruit toothpaste with oral mucosa protective effect
The described Noni fruit toothpaste with oral mucosa protective effect is composed of the following components:
10% glucityl-Benexate Hydrochloride, 47.3% calcium carbonate, 30% wetting agent, 6% binding agent, 3% lauryl alcohol
Sodium sulfate, 0.2% saccharin sodium, 1.2% essence, 0.3% sorbic acid and 2% deionized water；Described wetting agent is by sorbitol, poly-second
Glycol and oligochitosan form by weight 1:1:1；Described binding agent is pressed weight by Carboxymethyl cellulose sodium and lauryl glucoside
Measure and form than 5:2.
Preparation method is similar to Example 3.
Difference with embodiment 4 is, described wetting agent is by sorbitol, Polyethylene Glycol and oligochitosan 1:1:1 by weight
Composition.Comparative example 3, a kind of Noni fruit toothpaste with oral mucosa protective effect
The described Noni fruit toothpaste with oral mucosa protective effect is composed of the following components:
10% glucityl-Benexate Hydrochloride, 47.3% calcium carbonate, 30% wetting agent, 6% binding agent, 3% lauryl alcohol
Sodium sulfate, 0.2% saccharin sodium, 1.2% essence, 0.3% sorbic acid and 2% deionized water；Described wetting agent is by sorbitol, poly-second
Glycol and oligochitosan form by weight 3:2:0.8；Described binding agent is Carboxymethyl cellulose sodium.
Preparation method is similar to Example 3.
Difference with embodiment 4 is, described binding agent is Carboxymethyl cellulose sodium.
Comparative example 4, a kind of Noni fruit toothpaste with oral mucosa protective effect
The described Noni fruit toothpaste with oral mucosa protective effect is composed of the following components:
10% glucityl-Benexate Hydrochloride, 47.3% calcium carbonate, 30% wetting agent, 6% binding agent, 3% lauryl alcohol
Sodium sulfate, 0.2% saccharin sodium, 1.2% essence, 0.3% sorbic acid and 2% deionized water；Described wetting agent is by sorbitol, poly-second
Glycol and oligochitosan form by weight 3:2:0.8；Described binding agent is pressed by Carboxymethyl cellulose sodium and lauryl glucoside
Weight ratio 1:1 forms.
Preparation method is similar to Example 3.
Difference with embodiment 4 is, described binding agent is by Carboxymethyl cellulose sodium and lauryl glucoside by weight
Form than 1:1.
Test example one, there is the bactericidal assay of the Noni fruit toothpaste of oral mucosa protective effect
1, test material: embodiment 1, embodiment 2 and the Noni fruit with oral mucosa protective effect of embodiment 3 preparation
Toothpaste.
2, test method: measure embodiment to escherichia coli, golden yellow with reference to the method for GB15979-2002 appendix C 3 regulation
The bactericidal effect of color staphylococcus, Candida albicans, Streptococcus mutans and porphyromonas gingivalis.
3, result of the test:
Result of the test is as shown in table 1.
Table 1 has the bactericidal action of the Noni fruit toothpaste of oral mucosa protective effect
As shown in Table 1, the Noni fruit toothpaste with oral mucosa protective effect that the present invention provides is to escherichia coli, golden yellow
Color staphylococcus, Candida albicans, Streptococcus mutans and porphyromonas gingivalis have bactericidal action, and it kills colibacillary
Bacterium rate is more than 99.08%, the sterilizing rate of staphylococcus aureus is more than 98.24%, is more than the sterilizing rate of Candida albicans
99.12%, the sterilizing rate of Streptococcus mutans is more than 99.16%, the sterilizing rate of porphyromonas gingivalis is more than 98.04%.
The Noni fruit toothpaste with oral mucosa protective effect that the present invention provides, to oral mucosa, recurrent oral ulceration healing, presses down
Dental plaque processed, alleviate gingivitis there is significantly protection and therapeutical effect.
Test example two, there is the clinical trial to oral ulcer of the Noni fruit toothpaste of oral mucosa protective effect
1, test material: the Noni fruit toothpaste with oral mucosa protective effect of embodiment 4 preparation.
2, subjects: select 20-65 year recurrent aphtha (RAU) patient 80, be randomly divided into test group and
Matched group, often organizes each 40.
3, test standard: experimenter is to meet to include in and the NAM of exclusion standard and women.
3.1, inclusive criteria: whole body health in order, has RAU morbidity history but without whole body system disease；Can read,
Understand Informed Consent Form hope to be intended to above to sign, can be according to test requirements document record and participate in inspection at any time during testing；Mouthful
Intracavity at least an oral ulcer and ulcer time of origin are less than 48h；Allergy will not be there is in toothpaste and composition thereof；Do not make
Use other treatment stomatocace medicine；Do not use the custom of other oral cavity cleaning measures in addition to toothbrush, such as dental floss with gargle
Water, chew gum etc.；Participate in other similar experimental studies the most simultaneously.
3.2, exclusion standard: heavy recurrent aphtha, Behcet disease；General disease background such as anemia, digestibility are burst
Infections, crohn, acute infectious diseases, autoimmune disease etc.；Analgesic or treatment oral ulcer medicine is used in 24h
Thing；Using antibiotic, antibiotic medicine in 1 month, in 3 months, whole body uses corticosteroid, immunosuppressant；Smoking in 3 months,
Alcoholic；Tumor patient；Oral health care product or its composition there are allergies；It is in the women of trimester of pregnancy and age of sucking.
4, evaluation index:
4.1, average ulcerative stage (my god, D): evaluate ulcer period, summation persistent period total divided by ulcer.
4.2, pain index (dividing, P): use Visual analogue scale (VAS) to record the pain scores of ulcerative stage every day.VAS
Representing the straight line using 10cm, 0 end of straight line represents " painless ", and 10cm end represents " the most violent pain ".Experimenter is according to pain
The level of sensitivity of pain is different, and the corresponding scale at straight line keeps a record, every day 1 time.
Evaluation index classification: D1: average ulcerative stage shortens (t checks, P ＜ 0.05)；D0: (t examines in average ulcerative stage thing change
Test, P ＞ 0.05)；P1: pain index reduces (t checks, P ＜ 0.05)；P0: pain index unchanged (t checks, P ＞ 0.05).Comment
Price card is accurate: effective (D1P1)；Effectively (D1P0Or D0P1)；Invalid (D0P0)。
5, test method:
Church patient records pain index, issues " oral ulcer log ", and record experimenter's telephone number, issues simultaneously
Everyone a set of toothpaste, toothbrush, three before the meal 10min toothpaste is applied in affected part, take food again after Su Kou after 5min.Every day 2 times sooner or later,
Brush teeth according to oneself traditional approach with sent out toothpaste.Every day experimenter is carried out call-on back by phone subsequently, understands ulcer development, oral cavity
After ulcer healing, carrying out examination of mouth and reclaim " oral ulcer log ", test uses double-blind method to complete.
6, result of the test:
Result of the test is as shown in table 2 and table 3.
Table 2 pain index test data
As shown in Table 2, the Noni fruit toothpaste with oral mucosa protective effect using the present invention to provide can be significant
(P ＜ 0.05) reduces the pain of oral ulcer patient, has significantly treatment to oral ulcer.
Table 3 healing test data
As shown in Table 3, the Noni fruit toothpaste with oral mucosa protective effect using the present invention to provide can be significant
(P ＜ 0.05) shortens the ulcer time of oral ulcer patient, has significantly treatment to oral ulcer.
Test example three, the moisture retention of the Noni fruit toothpaste with oral mucosa protective effect are tested
1, test material: prepared by embodiment 3, embodiment 4, embodiment 5, comparative example 1 and comparative example 2 has oral mucosa
The Noni fruit toothpaste of protective effect.
2, test method: weigh the mastic of identical weight respectively, puts in same containers, makes mastic and air contact area
Equal, it is 20 DEG C in temperature, relative humidity is under the same terms of 54%, measures the fluid loss of each sample by weight method.Same
Under the conditions of sample, parallel three test determinations, average.Wherein: fluid loss=(sample-dehydration sample/sample) × 100%.
3, result of the test:
Result of the test is as shown in table 4.
Table 4 has the fluid loss of the Noni fruit toothpaste of oral mucosa protective effect and measures
As shown in Table 4, the Noni fruit toothpaste with oral mucosa protective effect that the present invention provides is 20 DEG C in temperature, phase
Under conditions of humidity is 54%, fluid loss during 48h be less than 5.8%, and comparative example 1 and comparative example 2 preparation there is oral cavity
The Noni fruit toothpaste of mucosa is 20 DEG C in temperature, and under conditions of relative humidity is 54%, fluid loss during 48h is more than
8.8%, illustrate that the present invention provides can phase by the wetting agent that certain weight ratio forms by sorbitol, Polyethylene Glycol and oligochitosan
Coordinate to strengthen the effect of moisturizing mutually.
Test example four, there is the viscosity test of the Noni fruit toothpaste of oral mucosa protective effect
1, test material: prepared by embodiment 3, embodiment 4, embodiment 5, comparative example 3 and comparative example 4 has oral mucosa
The Noni fruit toothpaste of protective effect.
2, test method: use rotary viscosimeter, under conditions of temperature is 28 DEG C measure sample in 90 days
Viscosity.
3, result of the test:
Result of the test is as shown in table 5.
Table 5 toothpaste viscosity is over time
As shown in Table 5, what prepared by embodiment of the present invention 1-3 has the viscosity of the Noni fruit toothpaste of oral mucosa protective effect
Rate of change over time is less, when 90 days, its viscosity be more than 13Pa s, and comparative example 3 and comparative example 4 preparation have
The viscosity of the Noni fruit toothpaste of oral mucosa protective effect rate of change over time is relatively big, when 90 days, its viscosity less than in
9Pa s, illustrates the binding agent being made up of Carboxymethyl cellulose sodium and lauryl glucoside that the present invention provides by constant weight
Interact and strengthened viscosity and the effect of stability of toothpaste, can effectively extend the shelf-life of toothpaste.
Claims (10)
1. a Noni fruit toothpaste with oral mucosa protective effect, it is characterised in that described Noni fruit toothpaste includes glucose
Group-beta-cyclodextrin clathrate, described glucityl-Benexate Hydrochloride comprises Noni fruit mixture and glucose group-beta-cyclodextrin,
Described Noni fruit mixture is made up of Noni extract, ethyl cellulose and Macrogol 4000.
There is the Noni fruit toothpaste of oral mucosa protective effect the most as claimed in claim 1, it is characterised in that described glucose
Group-beta-cyclodextrin clathrate addition in Noni fruit toothpaste is 1-15%.
There is the Noni fruit toothpaste of oral mucosa protective effect the most as claimed in claim 1, it is characterised in that described glucose
The preparation method of group-beta-cyclodextrin clathrate is:
Fresh Noni fruit is cleaned by S1, section, places under conditions of temperature is 35-45 DEG C and dry, pulverize 80-100 mesh sieve,
Fine powder；The ethanol solution that 6-8 times of volume fraction is 55-65% of above-mentioned fine powder gross weight, ultrasonic extraction is added in fine powder
25-35min, filters, obtains filtrate I；Then molten toward filtering residue adds the ethanol that 6-8 times of volume fraction of above-mentioned filtering residue is 65-75%
Liquid, ultrasonic extraction 20-30min, filters, filtrate II；Merging filtrate, reclaims ethanol under the conditions of temperature is 60 DEG C and concentrates filter
Liquid, obtains Noni extract；
The Noni extract that step S1 is obtained by S2 is mixed homogeneously with ethyl cellulose and Macrogol 4000, obtains Noni fruit
Mixture；
S3 adds water toward glucose group-beta-cyclodextrin, is configured to glucose group-beta-cyclodextrin saturated aqueous solution；
The Noni fruit mixture that step S2 is obtained by S4 adds in the glucose group-beta-cyclodextrin saturated aqueous solution that step S3 obtains,
Under conditions of temperature is 35-60 DEG C, stirs 2-5h, filters, filtering residue is dried under the conditions of 60 DEG C, cross 80 mesh sieves, through P2O5Dry
Dry, obtain glucityl-Benexate Hydrochloride.
There is the Noni fruit toothpaste of oral mucosa protective effect the most as claimed in claim 3, it is characterised in that described step S2
Middle Noni extract mixes with ethyl cellulose and Macrogol 4000 2-4:1-3:3-5 in mass ratio；Described step
In S4, Noni fruit mixture mixes with glucose group-beta-cyclodextrin 1:2-6 in mass ratio.
There is the Noni fruit toothpaste of oral mucosa protective effect the most as claimed in claim 4, it is characterised in that described step S2
Middle Noni extract mixes with ethyl cellulose and Macrogol 4000 3:2:4 in mass ratio；Promise in described step S4
Beautiful fruit mixture mixes with glucose group-beta-cyclodextrin 1:5 in mass ratio.
There is the Noni fruit toothpaste of oral mucosa protective effect the most as claimed in claim 1, it is characterised in that described Noni fruit
Toothpaste also includes component:
40-60% calcium carbonate, 18-40% wetting agent, 4-8% binding agent, 2-4% sodium lauryl sulfate, 0.1-0.4% saccharin
Sodium, 0.8-1.5% essence, 0.1-0.5% sorbic acid and 1-2% deionized water.
There is the Noni fruit toothpaste of oral mucosa protective effect the most as claimed in claim 6, it is characterised in that described Noni fruit
Toothpaste also includes following components:
47.3% calcium carbonate, 30% wetting agent, 6% binding agent, 3% sodium lauryl sulfate, 0.2% saccharin sodium, 1.2% essence,
0.3% sorbic acid and 2% deionized water.
There is the Noni fruit toothpaste of oral mucosa protective effect the most as claimed in claim 6, it is characterised in that described wetting agent
It is made up of by weight 2-4:1-3:0.5-1 sorbitol, Polyethylene Glycol and oligochitosan；Described binding agent is by Carboxymethyl cellulose sodium
Form by weight 4-6:1-3 with lauryl glucoside.
There is the Noni fruit toothpaste of oral mucosa protective effect the most as claimed in claim 8, it is characterised in that described wetting agent
It is made up of by weight 3:2:0.8 sorbitol, Polyethylene Glycol and oligochitosan；Described binding agent is by Carboxymethyl cellulose sodium and Laurel
Base glucoside forms by weight 5:2.
10. there is a preparation method for the Noni fruit toothpaste of oral mucosa protective effect, its feature as claimed in claim 6
It is, comprises the following steps:
S1 by calcium carbonate, wetting agent, binding agent, sodium lauryl sulfate, saccharin sodium, sorbic acid and deionized water vacuum be-
Stir under conditions of 0.08Mpa～0.10Mpa, obtain mixture；
Essence and glucityl-Benexate Hydrochloride is added in the mixture that step S1 obtains by S2, vacuum be-
Stir under conditions of 0.08Mpa～0.10Mpa, to obtain final product.
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| CN107875049A (en) * | 2017-10-20 | 2018-04-06 | 广州市西瑶玉池科技有限公司 | A kind of mothproof sound of baby talk cream of the mineral element containing the tremolite |
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