KR940006938B1 - Food composition for good health - Google Patents

Abstract

The health food composition contains one or more components selected from 10-150 wt.% ginseng extract contg. 4-27 % ginsenoside, 3-50 wt.% ginko leaves extract contg. 6-24 % ginkoflavon glycoside, 20-40 wt.% garlic extract and/or ginger extract contg. 90 % or more oxoamidine, and 5-100 wt.% of one or more of licorice, gardenia seed, Gastrodia elata Blume and guarana extract contg. 6-12 % alkaloid.

Description

Health food composition

The present invention relates to a health food composition containing ginseng and the like, and more particularly, to a health food composition of tablets, capsules or drinks containing ginseng, ginkgo biloba and garlic or ginger extract.

Ginseng, ginkgo biloba, garlic, ginger, etc. have been known for a long time as a herbal medicine or a folk remedy. Therefore, in recent years, various pharmaceutical forms of herbal formulations using these ingredients have been developed and marketed.

Among them, ginseng tonic drinks are mainly marketed. Ginseng leaf extracts are also marketed. Vascular improvement agents are mainly marketed. Other ingredients such as ganoderma lucidum, honey, ginseng, and pollen are also formulated in an appropriate amount. It is marketed as a nourishing tonic.

However, these products can not find a big characteristic technology in terms of simply using a herbal extract that has been used as a herbal medicine in the Orient in the past, it was mostly aimed at simply using the nourishing tonic or known efficacy.

In this situation, the development of a healthy food composition of the desired composition effective for the various nervous system and respiratory system caused by various adult diseases or pollution due to the improvement of living standards in recent years, in particular, by combining appropriately extracts of these herbal ingredients There is an urgent need for healthy foods that are effective in preventing or treating diseases.

Therefore, the present invention is to improve health, such as excellent prevention and treatment for various adult diseases and diseases of the respiratory tract with the main ingredients of stomach, ginkgo biloba and garlic or ginger in order to manufacture a health food composition of a new composition that has not been conventionally used in combination The purpose is to provide a new health food composition that has an effect.

Hereinafter, the present invention will be described in detail.

In the health food composition containing ginseng, (1) 10 to 150 parts by weight of ginseng extract containing 4 to 27% ginsenoside and (2) 6 to 24% ginkgo flavone glycoside 3 to 50 parts by weight of the extract, (3) 20 to 40 parts by weight of any one or two components selected from garlic extract and ginger extract containing 90% or more of oxoamidine, and (4) licorice, gardenia, sorghum and 6 to It is characterized in that it contains 5 to 100 parts by weight of any one or more components selected from the extract of Guarana containing 12% alkaloid.

Referring to the present invention in more detail as follows.

The present invention is a health food composition composed of ginseng extract, ginkgo biloba extract, garlic extract, ginger extract and the like as a main ingredient, mixed with other auxiliary ingredients and known additives, the ginseng component used in the present invention is well known As it is, it enhances various immunity, and is effective in anti-cancer, anti-diabetic, anti-aging, anti-stress and gastrointestinal function. This ginseng component is used as a ginseng extract containing 4 to 27% of ginsenosides, which is prepared by using an ultrasonic extractor according to the method described in Korean Patent No. 90-9853. 10-150 weight part mixes and uses.

In addition, the present invention also used ginkgo biloba extract, which was used as a conventional herbal medicine, but was not used as a liquid, the ginkgo biloba extract used here uses 3 to 50 parts by weight containing 6 to 24% of ginkgo flavo glycosides. It can manufacture by a well-known method. Such ginkgo biloba extract is already known for its efficacy, especially as a blood circulation improving effect on the brain and peripheral blood vessels, in addition to the brain function, anti-asthma, anti-allergic and nervous system strengthening effect. If the ginkgo biloba extract is used in excess of 50 parts by weight, it is also uneconomical, but especially when consumed as a drink, the bitter taste is strong and drinking is not desirable.

In the present invention, a mixture of any one or two components selected from garlic extract and ginger extract containing 90% or more of oxodiamine in addition to the above components is mixed and used so that the total amount thereof is 20 to 40 parts by weight. Garlic and ginger are also known to have medicinal effects in the private sector, but were not used in compositions such as health foods. Garlic is known to be effective in antibacterial, antithrombotic, anti-arteriosclerosis, anti-diabetic, anti-cancer, etc., ginger is known to be effective in strengthening heart, antipyretic analgesic, Jinhae, jinhae, gastrointestinal movement.

These garlic extracts can be lyophilized garlic powder containing 0.1% garlic oil or garlic extracts containing more than 90% oxoamidine, but in the case of powder, it is recommended to use garlic extract because of the possibility of precipitation. Extract or ginger extract can be prepared by using a cold or gown extraction method in an aqueous solution or an aqueous alcohol solution in a conventional manner.

In addition, the composition of the present invention uses a mixture of at least one component of Glycyrrhiga, Gardenia Gastrodia and 6-12% alkaloid-containing Guarana in 5 to 100 parts by weight. It is effective in promoting digestion, anti-ulcer, anti-viral, anti-inflammatory and anti-allergic effect. Gardenia has effects such as diarrhea, liver protection, antibacterial, anti-fungal, antipyretic, hemostasis, and cheonma has lowered blood pressure, lowered blood lipid, and strengthened nervous system. , Anticonvulsions, brain function (dry skin), pain is effective. Guarana also has anti-fatigue, diuretic, and convergent effects.

Among these components, Gardenia, Cheonma, etc. are freeze-dried or reduced-pressure dry powder or liquid extract obtained by removing the insoluble material by cold or warm extraction with an aqueous or alcoholic solution, and licorice and guarana are extracted with an aqueous ethyl alcohol solution and concentrated under reduced pressure. Use the obtained extract.

In particular, the present invention has a synergistic effect due to the mixing composition of the main active ingredients as described above, it shows an excellent health promoting effect in various diseases of the adult and respiratory organs, anti-cancer effect and the like. In particular, the composition of the present invention, as shown in Table 1 comparing the arterial pressure on the rats of the new composition in the examples to be described later than ginseng, garlic or ginseng, ginger mixed with ginkgo biloba extract alone It can be seen that the composition is more effective for health promotion.

On the other hand, the composition of the present invention, in addition to the main components, as a secondary component, vitamins A, D, C, B, E or K, Ca, Mg, Fe, Cu, Zn, Mn, Mo, CO, I, F, P minerals Phospholipid-containing compounds, phospholipids such as lecithin, sterol compounds such as β-sitosterol, compounds such as citric acid, amino acids, and pangamic acid. Among these, vitamins C, E, Ca, Zn, lecithin, citric acid and plate It is more preferable to mix and use two to three components in 10 to 200 parts by weight in subtraction or the like, since the bioactive effect can be enhanced or enhanced.

In addition to the above ingredients, in order to enhance the taste as a known additive, natural flavors such as rose, lemon, vanilla or peppermint or natural pigments such as chlorophyllin and flavonoids and sweeteners such as glucose, honey, You can mix and use sugar.

As described above, the present invention can be prepared as tablets, capsules, drinks, etc. as a new natural extract composition, unlike the composition in the conventional general health food composition, drink is excellent in drinking, especially simple nutritious tonic In addition to the effects, it is a health food composition having excellent effects on health promotion, such as preventing various adult diseases, preventing respiratory diseases and anti-cancer effects.

Hereinafter, the present invention will be described in detail with reference to Examples.

Reference Example 1

Preparation of Ginkgo Leaf Extract

According to the method of the already known Korean Patent Publication No. 90-5319, 10 kg of the dry powder of ginkgo biloba leaves were put into 100 혼합 of a mixed solvent of methyl alcohol-methyl ethyl ketone (2: 1), extracted for 9 hours while refluxing, and the filtrate was filtered. Concentrate. 100% of 30% acetone aqueous solution was added to the concentrate to dissolve the solution, and 50% aqueous NaCl solution was added thereto. Then, the pH was adjusted to 4 with a weak alkali aqueous solution, and the resulting precipitate was filtered and removed.

The filtrate was neutralized again with an aqueous alkali solution and concentrated to dryness to obtain 1.2 kg of solid powder. The powder was dissolved in 20 alcohol of ethyl alcohol to remove the precipitate, and the resultant solution was added with bismuth nitrate suspension and stirred. Then, the mixture was concentrated under reduced pressure to 7 ι, repeated three times with butyl alcohol 7 ι, and concentrated under reduced pressure to 3 ι. Then 50% ethyl alcohol aqueous solution 50ι was added and dissolved, and the resultant precipitate was filtered for 24 hours at low temperature (-2 to -5 ° C), and the filtrate was concentrated under reduced pressure to obtain 240 g of purified extract. The extract obtained at this time can be confirmed by a known method that contains 20-25% of the active physiologically active ginkgo flavone glycoside (see National Pharmaceutical Standards and Test Methods, Pharmaceutical Newspaper, 1990).

Reference Example 2

Preparation of Ginseng Extract

1kg of ground ginseng powder finely pulverized into 100 mesh is placed in an ultrasonic extractor containing 3ι distilled water, the frequency is adjusted to 25KHz, extracted at room temperature for 3 hours, and the extract is filtered. The filtrate is concentrated under reduced pressure to obtain ginseng extract 330g. The ginseng extract obtained at this time contains 20-27% of ginsenoside (total ginseng glycosides) (confirmation method: domestic drug standards and test methods, medicinal newspapers, 1990).

Reference Example 3

Preparation of Garlic Extract

5 kg of garlic is fumigated with steam for 20 minutes and then crushed.

Put the ground garlic and purified water 25ι into the reactor, stirred and extracted at room temperature for 4 days, and then refluxed while stirring again at 100 ° C for 5 hours, and cooled and centrifuged to add 20 butyl alcohol to the filtrate, and the organic solvent layer was sufficient. Throw away.

The separated aqueous layer was concentrated to a specific gravity of 1.15 and added dropwise while stirring to 20ι of ethyl alcohol. At this time, the resulting precipitate is filtered and dried under reduced pressure at 50 ℃ to obtain a 75g garlic extract.

The extract obtained at this time contains more than 90% of oxoamidine, the main bioactive substance of garlic (Confirmation method: domestic pharmaceutical standards and test methods, Pharmaceutical Newspaper, 1990)

Reference Example 4

Preparation of Ginger Extract

5kg of dried ginger is placed in 30% of 50% ethanol and extracted for 5 hours while refluxing, and the filtrate is concentrated by 10ι. After leaving for 24 hours at low temperature (-2 ℃ ~ -5 ℃) to remove the precipitate formed, the filtrate was concentrated under reduced pressure to 5ι and lyophilized to obtain 750g ginger extract.

Example 1

(Furtherance)

Ginseng Extract 40mg (Contains 7% Ginsenosides)

Ginkgo biloba extract 20mg (contains 24% ginkgo flavone glycosides)

Garlic Extract 20mg (contains 90% oxoamidine)

Chunma Extract 60mg

Zinc Sulfide 10mg

Lecithin 12mg

The components of the composition were mixed well and mixed directly to prepare tablets of the health food composition. Using the health food composition prepared in Example 1 was tested the rat arterial peak blood pressure trends are shown in Table 1 below.

Example 2

(Furtherance)

Ginseng Extract 40mg (Contains 7% Ginsenosides)

Ginkgo biloba extract 10mg (containing ginkgo flavone glucoside 24%) 50mg

Ginger Extract 50mg

Guarana Extract 50mg (with 12% alkaloids)

10 mg glucose

Vitamin C 8mg

Honey 10mg

15 mg of sugar

10 mg citric acid

4mg of lemon flavored natural flavor was added to the composition, distilled water was added to make a total of 50ml, and the mixture was well mixed, passed through a filtration membrane, filled into a bottle, and sterilized and sealed to prepare a healthy beverage composition. Experimental trend of arterial hypertension in rats using the health food composition prepared by Example 2 is shown in Table 1 below.

Table 1 Peak Arterial Blood Pressure Trend in Rats

In the above values,

* P lower than 0.05

P lower than 0.01

* * * P lower than 0.001

Example 3

In the same manner as in Example 1, but using a ginseng extract 100mg, ginkgo biloba extract 40mg, garlic extract 50mg, Cheonma 60mg to prepare a soft cap health food.

Example 4

In the same manner as in Example 2, but using a mixture of ginseng extract 100mg, ginkgo biloba extract 40mg and ginger extract instead of garlic extract 50mg and ginger extract 20mg in the composition to prepare a soft capsule health food.

Example 5

The same composition as in Example 2, but in the composition ginseng extract 40mg, ginkgo biloba extract 20mg, ginger extract 20mg, and instead of guarana extract licorice extract 20mg and gardenia extract 40mg mixture using the same, the rest of the health food of the tablet Was prepared.

Example 6

In the same manner as in Example 5, but was carried out in the composition ginseng extract 100mg, ginkgo biloba extract 40g, ginger extract 20mg, licorice extract 40mg, gardenia extract 80mg.

Example 7

In the same manner as in Example 4, but in the composition ginseng extract 40mg, ginkgo biloba extract 10mg, garlic extract 50mg, ginger extract 50mg, licorice 40mg to prepare a healthy drink.

Example 8

It was carried out in the same composition as in Example 4, but in the composition ginseng extract 40mg, ginkgo biloba extract 20mg, garlic extract 20mg, ginger extract 20mg to prepare a healthy food of tablets.

The health food composition according to the present invention prepared as described above may be appropriately different in composition within the scope of the present invention in addition to the composition as described above, and may be prepared while changing the formulation.

Claims (1)

A health food composition containing ginseng, comprising: (1) 10 to 150 parts by weight of ginseng extract containing 4 to 27% ginsenosides, and (2) 3 to 3 ginkgo leaf extracts containing 6 to 24% ginkgo flavone glycosides. 50 parts by weight, (3) 20 to 40 parts by weight of any one or two components selected from garlic extract and ginger extract containing 90% or more of oxoamidine, and (4) licorice, gardenia, sorghum and 6 to 12% A health food composition comprising 5 to 100 parts by weight of any one or more components selected from extracts of guarana containing alkaloids.