CN106962904A - Ward off Gu Dan and preparation method thereof - Google Patents
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- CN106962904A CN106962904A CN201710096865.6A CN201710096865A CN106962904A CN 106962904 A CN106962904 A CN 106962904A CN 201710096865 A CN201710096865 A CN 201710096865A CN 106962904 A CN106962904 A CN 106962904A
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8969—Polygonatum (Solomon's seal)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
- A61K35/64—Insects, e.g. bees, wasps or fleas
- A61K35/644—Beeswax; Propolis; Royal jelly; Honey
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/076—Poria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/72—Rhamnaceae (Buckthorn family), e.g. buckthorn, chewstick or umbrella-tree
- A61K36/725—Ziziphus, e.g. jujube
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/77—Sapindaceae (Soapberry family), e.g. lychee or soapberry
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
- A61K36/815—Lycium (desert-thorn)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/894—Dioscoreaceae (Yam family)
- A61K36/8945—Dioscorea, e.g. yam, Chinese yam or water yam
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
Abstract
Ward off Gu Dan and preparation method thereof the present invention relates to one kind, raw material components by weight, including：20~40 parts of 20~30 parts of sealwort, 10~20 parts of radix polygonati officinalis, 5~10 parts of jujube, 6~9 parts of matrimony vine, 5~8 parts of longan, 5~10 parts of Poria cocos, 6~10 parts of Chinese yam, 6~8 parts of Semen sesami nigrum, 200~280 parts of yellow rice wine and honey.What the present invention was provided wards off Gu Dan, can avoid the use for the conventional medicament that side effect is larger and therapeutic effect is undesirable, and the Gu Dan that wards off prepared has significant effect of weight reducing, and instant effect, have hypoglycemic and hypotensive effect concurrently simultaneously, safe without toxic side effect is with low cost.
Description
Technical field
The present invention relates to technical field of pharmaceuticals, and in particular to one kind wards off Gu Dan and preparation method thereof.
Background technology
Pi Gudanshi Taoist schools " prey " " regimen " most important part, the day the succession of teachings from masters to disciples Zhang Daoling of Han dynasty is that Taoism is first in history
Gu Dan inventor is warded off in position, once made " Tai Qingdan ", and had arrived early Medieval China, supernatant sends the second generation founder (of a school of learning) poplar legendary ruler of great antiquity, the first of the Three August Ones that " cloud has been made
Instrument wards off Gu Dan ".It is that the energy-dense foods of some concentration property are formed into red medicine to ward off Gu Dan, and its purpose is to ward off the famine except the follower of Taoism
The effects such as starving, and reach mediation the five internal organs, get rid of illness, preserve youthful looks, returning strong, long-lived.The traditional preparation method for warding off Gu Dan of current China
The step of be：Select herbal medicine, it is broken beat powder, honey boil, craft or machine pill.What current market was made wards off the red main component of paddy also
Be some enrich blood, the herbal medicine of beneficial the five internal organs, raw material is mainly based on plantation class herbal medicine, mainly even changed with sulphur in anti-corrosion measure
Length of schooling agent, this kind of herbal medicine of long-term taking, not only effect is little, it could even be possible to unhealthful；Furthermore, what is prepared wards off Gu Dan
Herbal medicine thick taste, is not easy to long-term taking.Therefore, it is necessary to transform traditional Gu Dan that wards off, Gu Danben is warded off to overcome
The defect that body is present, while optimizing its therapeutic efficiency to illness.
The content of the invention
For defect of the prior art, present invention aims at providing one kind to ward off Gu Dan and preparation method thereof, to avoid
The use for the conventional medicament that side effect is larger and therapeutic effect is undesirable, the Gu Dan that wards off prepared has significant slimming exercise
Effect, and instant effect, while having hypoglycemic and hypotensive effect concurrently, safe without toxic side effect is with low cost.
To achieve the above object, the technical scheme that provides of the present invention is：
In a first aspect, ward off Gu Dan the invention provides one kind, raw material components by weight, including：
20~30 parts of sealwort, 10~20 parts of radix polygonati officinalis, 5~10 parts of jujube, 6~9 parts of matrimony vine, 5~8 parts of longan, Poria cocos 5~10
20~40 parts of part, 6~10 parts of Chinese yam, 6~8 parts of Semen sesami nigrum, 200~280 parts of yellow rice wine and honey.It should be noted that sealwort is excellent
Choosing uses health product, partially the sealwort raw material more than plump, juice.
In the further embodiment of the present invention, raw material components also include：1~5 part of spina date seed, 2~3 parts of peach kernel, mulberry
2~5 parts of 1~4 part of leaf and rose.
The present invention further embodiment in, raw material components by weight, including：25 parts of sealwort, 15 parts of radix polygonati officinalis,
7.5 parts of jujube, 7.5 parts of matrimony vine, 7.5 parts of longan, 7.5 parts of Poria cocos, 7.5 parts of Chinese yam, 7.5 parts of Semen sesami nigrum, 2.5 parts of spina date seed, peach
30 parts of 2.5 parts of benevolence, 2.5 parts of mulberry leaf, 2.5 parts of rose, 250 parts of yellow rice wine and honey.
In the further embodiment of the present invention, raw material components also include：10~15 parts of Ilex Latifolia Thunb, 3~8 parts of hawthorn,
2~4 parts of 1~2 part of Asian puccoon, 5~7 parts of water chestnut, 8~12 parts of the root of kudzu vine and wormwood.
The present invention further embodiment in, raw material components by weight, including：25 parts of sealwort, 15 parts of radix polygonati officinalis,
7.5 parts of jujube, 7.5 parts of matrimony vine, 7.5 parts of longan, 7.5 parts of Poria cocos, 7.5 parts of Chinese yam, 7.5 parts of Semen sesami nigrum, 2.5 parts of spina date seed, peach
2.5 parts of benevolence, 2.5 parts of mulberry leaf, 2.5 parts of rose, 12 parts of Ilex Latifolia Thunb, 5 parts of hawthorn, 1.5 parts of Asian puccoon, 6 parts of water chestnut, 10 parts of the root of kudzu vine and
30 parts of 3 parts of wormwood, 250 parts of yellow rice wine and honey.
Sealwort, it is sweet, it is mild-natured, the effects such as with strengthening by means of tonics internal organ, antibacterial, tonifying Qi and blood, hypotensive, available for treating
Diabetes and other diseases.Radix polygonati officinalis, it is sweet, it is mild-natured, attach to the lung and stomach meridians, with preserving youthful looks, moisturizing, eliminate disease and prolong life, nourish qi and blood, anti-aging,
Promote the production of body fluid, the effects such as hypoglycemic, blood fat, blood pressure.Jujube, property sugariness temperature, returns spleen, stomach, Vitamin C content enriches, and every 100 grams reach
To 300 milligrams of vitamins, the effects such as being had a sleepless night with blood-enriching face-nourishing, treatment.Matrimony vine, property is sweet, and taste is put down, and carotene carotene content is very high, also
Containing a large amount of mineral elements, amino acid can also strengthen eyesight, hypoglycemic, have effects that nourishing the liver, nourshing kidney, moistening lung, available for treating
The illnesss such as immune deficiency, hyperglycaemia, fatty liver, hypertension.Longan, there is a variety of nutriments, there is a blood-enriching tranquillizing, brain tonic and intelligence development,
Take a tonic or nourishing food to build up one's health effect of heart spleen；Dried longan has the ability of extremely strong removing free radical, has radioresistance, prevention cardiovascular and cerebrovascular disease, carries
The effects such as high immunity, anti-aging.Poria cocos, nature and flavor, Gan Danping enter the heart, lung, the spleen channel, with eliminating dampness and diuresis, strengthening the spleen and stomach,
Effect of antitoxic heart-soothing and sedative.Chinese yam, it is sweet, mild-natured, it is not dry oiliness, enter lung, spleen, kidney channel, with strengthening the spleen and tonifying the lung, beneficial stomach kidney tonifying, consolidate
Kidney strengthening the essence, hearing-improing and eyesight improving, the five internal organs, strengthening the bones and muscles, long will to calm the nerves, the effect promoted longevity are helped, for weakness of the spleen and the stomach, diet is reduced,
Suffer from diarrhoea loose stool；Women's lukorrhagia due to hypofunction of the spleen；Chronic cough of deficiency lung dry throat；Emission due to the kidney deficiency.Cure mainly weakness of the spleen and the stomach, lassitude, poor appetite, long
Let out dry protracted dysentery, Lung Qi deficiency, asthma due to excessive phlegm cough, kidney qi loss, soreness and weakness of waist and knees, lower limb impotence is weak, frequent micturition of quenching one's thirst, red with lower gonorrhoea, skin
The illnesss such as swollen, obesity.Semen sesami nigrum, property sugariness is put down, Return liver, kidney, large intestine channel, with filling liver kidney, benefiting essence-blood and the dry effect of ease constipation,
For illnesss such as dizzy, Hiccough and deaf, poliosis, post disease alopecia and dry constipation of intestines.Spina date seed, sweet, acid is mild-natured,
Fat oil containing volume and protein, and containing sterol, triterpenes, jujuboside, volume vitamin C；Have calmness, hypnosis, analgesia,
Anticonvulsant action, has certain antihypertensive effect, has excitation to uterus, has effects that to nourish conscience, calms the nerves and arrest sweating.Peach
Benevolence, bitter but sweet flavor and it is mild-natured, enter the heart, liver, large intestine channel, with promoting blood circulation, relax bowel, relieving cough and asthma effect, for Amenorrhea
Dysmenorrhoea, lump in the abdomen lump in the abdomen lump in the abdomen, lung carbuncle acute appendicitis, injury from falling down, dry constipation of intestines, the illness such as cough and asthma.Mulberry leaf, it is bitter, sweet, it is cold in nature, return
Lung, Liver Channel, have effects that clearing liver nourishing the liver, dispelling wind and heat from the body, clearing lung-heat, improving eyesight, for anemopyretic cold, wind-warm syndrome from the beginning of, fever and headache,
Perspiration and aversion to wind, pectoralgia of coughing；Or dryness of the lung dry cough without phlegm；Dry throat and mouth；Disturbed on wind-heat and liver-yang；The illnesss such as red eye, swell pain.Rose
Flower, warm-natured, sweet and slightly bitter taste, Return liver, the spleen channel, have effects that nourishing the stomach, promoting blood circulation for regulating menstruation, relax bowel, resolving stagnation for tranquilization, available for controlling
Treat the illnesss such as not enough, the hepatogastric function imbalance of vim and vigour.Ilex Latifolia Thunb, property is sweet, bitter, cold, enter liver, lung, stomach, with dissipate wind-heat, clear head
The effects such as mesh, relieving thirst and restlessness, it can be used to treat the illnesss such as headache, toothache, hot eyes, pyreticosis polydipsia, dysentery.Hawthorn, sour warm-natured, gas
Blood is simultaneously walked, and stagnation resolvation is without hindering new blood, and row stagnant gas is without hindering healthy tendency, and applied to meat stagnation card, diarrhea dysentery abdominal pain, hernia pain, the stasis of blood are stagnant
Stomachache pectoralgia, lochiorrhagia, dysmenorrhoea, spit blood, have blood in stool.Asian puccoon, cold in nature, sweet, salty, the thoughts of returning home, Liver Channel, with hemostatic, cool
The effects such as blood medicine, heat-clearing and detoxifying drug, cool blood is cured mainly, invigorated blood circulation, promoting eruption of detoxifying.For blood-heat and toxin exuberance, atropurpureus macula, measles without adequate eruption,
Sore, eczema, scald, clearing heat and cooling blood, for measles, pyreticosis ecchymosis, eczema, hematuria, blood strangury, bloody flux, sore, erysipelas,
Burn, the illness such as constipation with heat retention.Water chestnut, it is cold in nature, it is sweet, there is relieving heat and thirst, dampness removing resolving sputum, hypotensive, can be used for
Treat consumption of body fluid caused by febrile disease polydipsia, abscess of throat, stomatitis, jaundice with damp-heat pathogen, high blood pressure, difficult urination, measles, cough with lung heat, silicon
Lung, the illness such as hemorrhoid hemorrhage.The root of kudzu vine, cool in nature, pungent, sweet, returns spleen, stomach, lung, bladder warp, bring down a fever, promote the production of body fluid to quench thirst with inducing diaphoresis,
Effect of expelling pathogenic factors from muscles and skin analgesic, available for illnesss such as treatment fever caused by exogenous pathogens headache, neck pain, measless without adequate eruption.Wormwood, bitter in taste, pungent,
Temperature, enters spleen, liver and kidney channel, has effects that the antiabortive Zhi Beng ﹑ dispelling cold and removing dampnesses of menstruation regulating Zhi Xue ﹑, available for treatment menstruation Bu Tiao ﹑ dysmenorrhoea
Abdomen pain ﹑ miscarriage ﹑ uterine hemorrhages, radical cure of rheumatic closes the illness such as wind in the section ﹑ wind ﹑ months of inflammation.
Yellow rice wine, be a class with rice, milled glutinous broomcorn millet, corn, millet, wheat etc. for primary raw material, using boiling, plus distiller's yeast, sugar
The brewed wine for changing, ferment, squeezing, filter, decocting wine, store, blend, lives containing physiology such as polyphenol, melanoidin, glutathione
Property composition, with remove free radical, prevention of cardiovascular disease, anticancer, anti-ageing physiological function of waiting for a long time.The inorganic salts detected in yellow rice wine
Up to 18 kinds, including calcium, magnesium, potassium, phosphorus, iron, zinc, etc..The content of vitamin B, E in yellow rice wine is also very abundant, essentially from raw material
And yeast autolyzate.Protein content in yellow rice wine be in wine most, the protein content of every liter of Shaoxing Rice Wine reaches 16g, is
4 times of beer.The many forms with peptide and amino acid of protein in yellow rice wine are present, and are easily absorbed by the body.Peptide have trophic function,
Biological function and regulatory function.Yellow rice wine is containing abundant functional oligose, such as the isomaltose in every liter of Shaoxing Rice Wine, Pan
Sugar, Isomaltotriose content reach 6g.These oligosaccharide are that in brewing process, material is produced through the effect of microbial enzyme.
Functional oligose enters after human body, is hardly absorbed by the body, does not produce heat, but beneficial microbe in enteron aisle can be promoted double
Growing for discrimination bacillus, can improve function of intestinal canal, strengthen immunity, promote health.
The nectar that honey is insect honeybee to be adopted from the spending of flowering plant, the honey brewed in honeycomb.Honeybee is from plant
Spend in take the nectar or secretion that water content is about 80%, be stored in oneself second stomach, the effect of invertase in vivo
The lower fermentation for passing through 30 minutes, returns in honeycomb and spues, and temperature is always maintained at 35 DEG C or so in honeycomb, after a period of time,
Moisture evaporation, the honey as moisture less than 20%, is stored into nest hole, is sealed with beeswax.The composition of honey is except Portugal
Also contain various vitamins, mineral matter and amino acid outside grape sugar, fructose.1 kilogram of honey contains the heat of 2940 cards.Honey
It is the supersaturated solution of sugar, crystallization can be produced during low temperature, generation crystallization is glucose, the part that crystallization is not produced is mainly fruit
Sugar.Honey is described as in the Nature most perfect nutraceutical, and Greeks regard honey as the present being bestowed by heaven.China from ancient times just
Start artificial bee-keeping gathering honey, honey is both good medicine, is first-class beverage again, can promote longevity.It can be additionally used in health product for beauty treatment.Honeybee
Honey also has certain curative effect to some chronic diseases.Informal dress honey for heart disease, hypertension, tuberculosis, illness in eye, hepatopathy, dysentery,
Constipation, anaemia, the nervous system disease, gastric duodenal ulcer disease etc. have good medical assistance effect.Honey contains it
His indispensable trace element of a variety of human bodies, so still natural cosmetic health product, enjoys favor.Grape in honey
Sugar, vitamin, magnesium, phosphorus, calcium etc. can adjust nervous system, promote sleep simultaneously, and the enzyme and mineral matter contained in honey is helped
Improve immunity.
Second aspect, the invention provides the preparation method for warding off Gu Dan, comprises the following steps：S101：After sealwort is cleaned
Section, is then placed in yellow rice wine and boils；S102：The product that S101 is obtained is added after other raw material components in addition to honey are cleaned
In, boil again；S103：The obtained products of S102 are dried into constant weight crushing, dry powder is obtained；S104：S103 is obtained
Pill after product and honey are well mixed, obtains warding off Gu Dan.
In the further embodiment of the present invention, in S101 and S102, the temperature boiled is 80~100 DEG C, is boiled
Time is 30~45min.
In the further embodiment of the present invention, in S103, the temperature of drying is 100~150 DEG C.
In the further embodiment of the present invention, in S103, the particle diameter of the dry powder after crushing is less than or equal to 0.15mm.
In the further embodiment of the present invention, in S103, also comprise the following steps：Dry powder and yellow rice wine are well mixed
Afterwards, 5~6h is stood at 20~30 DEG C, is then heated at 60~70 DEG C after 80~90min, regulation pH value to 9.0~10.5,85
~90 DEG C of 10~15min of heating, by obtained mixture in 120~135 DEG C of drying to constant weight；Wherein, in S101 and S103
The ratio of yellow rice wine is (2.5~3):1.
It should be noted that in S104, by the well mixed rear pill of the obtained products of S103 and honey, what is prepared wards off
Gu Dan, the quality of every red ball is preferably 1g, naturally it is also possible to be other quality sizes.What the present invention was provided wards off Gu Dan food
It is with method：Three times a day, per less preferred edible 5g, daily 15g, eating method is eaten respectively after the meal for early, neutralization dinner, is eaten
It was a course for the treatment of with 7 days, it is edible to be adjusted according to the state of an illness total time.
The technical scheme that the present invention is provided, with following beneficial effect：(1) present invention is by using sealwort, radix polygonati officinalis, big
Jujube, matrimony vine, longan, Poria cocos, Chinese yam, Semen sesami nigrum, yellow rice wine and honey and other substances are as raw material, and what is prepared wards off Gu Dan with aobvious
The effect of weight reducing of work, and instant effect, while having hypoglycemic and hypotensive effect concurrently；(2) what the present invention was prepared wards off Gu Dan
, can be with long-term taking, rich in several mineral materials and vitamin in the absence of specific peculiar smell, in good taste, the red ball being made can be with
Directly take, similarly suitable the elderly is edible；(3) what the present invention was prepared wards off the red safe without toxic side effect of paddy, to body
It is harmless；(4) preparation method for warding off Gu Dan that the present invention is provided is simple, and production cost is low.
The additional aspect and advantage of the present invention will be set forth in part in the description, and will partly become from the following description
Obtain substantially, or recognized by the practice of the present invention.
Embodiment
Technical scheme is clearly and completely described below in conjunction with the embodiment of the present invention.Implement below
Example is only used for clearly illustrating technical scheme, therefore is intended only as example, and can not limit this hair with this
Bright protection domain.
Experimental method in following embodiments, is conventional method unless otherwise specified.Examination used in following embodiments
Material is tested, is to be commercially available from conventional reagent shop unless otherwise specified.Quantitative test in following examples, is all provided with
Three repetition experiments are put, data are the average value or mean+SD of three repetition experiments.
The present invention provides one kind and wards off Gu Dan, raw material components by weight, including：20~30 parts of sealwort, radix polygonati officinalis 10~20
Part, 5~10 parts of jujube, 6~9 parts of matrimony vine, 5~8 parts of longan, 5~10 parts of Poria cocos, 6~10 parts of Chinese yam, 6~8 parts of Semen sesami nigrum, Huang
20~40 parts of 200~280 parts of wine and honey.
Preferably, raw material components also include：1~5 part of spina date seed, 2~3 parts of peach kernel, 1~4 part of mulberry leaf and rose 2~5
Part.
Preferably, raw material components also include：10~15 parts of Ilex Latifolia Thunb, 3~8 parts of hawthorn, 1~2 part of Asian puccoon, water chestnut 5~7
2~4 parts of part, 8~12 parts of the root of kudzu vine and wormwood.
In addition, present invention also offers the above-mentioned preparation method for warding off Gu Dan, comprising the following steps：
S101：Cut into slices after sealwort is cleaned, be then placed in yellow rice wine, 30~45min is boiled at 80~100 DEG C；
S102：Added after other raw material components in addition to honey are cleaned in the product that S101 is obtained, again 80~100
DEG C boil 30~45min；
S103：The product that S102 is obtained is crushed after 100~150 DEG C of drying to constant weights, is obtained particle diameter and is less than or equal to
0.15mm dry powder；
S104：By the well mixed rear pill of the obtained products of S103 and honey, obtain warding off Gu Dan.
Preferably, in S103, also comprise the following steps：By dry powder and yellow rice wine it is well mixed after, stand 5 at 20~30 DEG C~
6h, then heats after 80~90min, regulation pH value to 9.0~10.5 at 60~70 DEG C, 10~15min is heated at 85~90 DEG C,
By obtained mixture in 120~135 DEG C of drying to constant weight；Wherein, the ratio of the yellow rice wine in S101 and S103 is (2.5~3):
1。
The Gu Dan and preparation method thereof that wards off provided with reference to specific embodiment the present invention is described further.
Embodiment one
The present embodiment provides one kind and wards off Gu Dan, raw material components by weight, including：20 parts of sealwort, 20 parts of radix polygonati officinalis, jujube
40 parts of 5 parts, 9 parts of matrimony vine, 5 parts of longan, 10 parts of Poria cocos, 6 parts of Chinese yam, 8 parts of Semen sesami nigrum, 200 parts of yellow rice wine and honey.
By above-mentioned raw material, the preparation method for warding off Gu Dan provided using the present invention, Gu Dan is warded off in preparation：
S101：Cut into slices after sealwort is cleaned, be then placed in yellow rice wine, 45min is boiled at 80 DEG C；
S102：Add in the product that S101 is obtained, boiled at 100 DEG C after other raw material components in addition to honey are cleaned
30min；
S103：The product that S102 is obtained is crushed after 100 DEG C of drying to constant weights, obtains particle diameter less than or equal to 0.15mm
Dry powder；
S104：By the well mixed rear pill of the obtained products of S103 and honey, obtain warding off Gu Dan.
Embodiment two
The present embodiment provides one kind and wards off Gu Dan, raw material components by weight, including：30 parts of sealwort, 10 parts of radix polygonati officinalis, jujube
20 parts of 10 parts, 6 parts of matrimony vine, 8 parts of longan, 5 parts of Poria cocos, 10 parts of Chinese yam, 6 parts of Semen sesami nigrum, 280 parts of yellow rice wine and honey.
By above-mentioned raw material, the preparation method for warding off Gu Dan provided using the present invention, Gu Dan is warded off in preparation：
S101：Cut into slices after sealwort is cleaned, be then placed in yellow rice wine, 45min is boiled at 100 DEG C；
S102：Add in the product that S101 is obtained, boiled at 80 DEG C after other raw material components in addition to honey are cleaned
30min；
S103：The product that S102 is obtained is crushed after 150 DEG C of drying to constant weights, obtains particle diameter less than or equal to 0.15mm
Dry powder；
S104：By the well mixed rear pill of the obtained products of S103 and honey, obtain warding off Gu Dan.
Embodiment three
The present embodiment provides one kind and wards off Gu Dan, raw material components by weight, including：25 parts of sealwort, 15 parts of radix polygonati officinalis, jujube
7.5 parts, 7.5 parts of matrimony vine, 7.5 parts of longan, 7.5 parts of Poria cocos, 7.5 parts of Chinese yam, 7.5 parts of Semen sesami nigrum, 250 parts of yellow rice wine and honey 30
Part.
By above-mentioned raw material, the preparation method for warding off Gu Dan provided using the present invention, Gu Dan is warded off in preparation：
S101：Cut into slices after sealwort is cleaned, be then placed in yellow rice wine, 40min is boiled at 90 DEG C；
S102：Add in the product that S101 is obtained, endured again at 85 DEG C after other raw material components in addition to honey are cleaned
35min processed；
S103：The product that S102 is obtained is crushed after 120 DEG C of drying to constant weights, obtains particle diameter less than or equal to 0.15mm
Dry powder；
S104：By the well mixed rear pill of the obtained products of S103 and honey, obtain warding off Gu Dan.
Example IV
The present embodiment provides one kind and wards off Gu Dan, raw material components by weight, including：20 parts of sealwort, 20 parts of radix polygonati officinalis, jujube
5 parts, 9 parts of matrimony vine, 5 parts of longan, 10 parts of Poria cocos, 6 parts of Chinese yam, 8 parts of Semen sesami nigrum, 1 part of spina date seed, 3 parts of peach kernel, 1 part of mulberry leaf, rose
Spend 5 parts, 40 parts of 200 parts of yellow rice wine and honey.
By above-mentioned raw material, the preparation method for warding off Gu Dan provided using the present invention, Gu Dan is warded off in preparation：
S101：Cut into slices after sealwort is cleaned, be then placed in yellow rice wine, 45min is boiled at 80 DEG C；
S102：Add in the product that S101 is obtained, boiled at 100 DEG C after other raw material components in addition to honey are cleaned
30min；
S103：The product that S102 is obtained is crushed after 100 DEG C of drying to constant weights, obtains particle diameter less than or equal to 0.15mm
Dry powder；
S104：By the well mixed rear pill of the obtained products of S103 and honey, obtain warding off Gu Dan.
Embodiment five
The present embodiment provides one kind and wards off Gu Dan, raw material components by weight, including：30 parts of sealwort, 10 parts of radix polygonati officinalis, jujube
10 parts, 6 parts of matrimony vine, 8 parts of longan, 5 parts of Poria cocos, 10 parts of Chinese yam, 6 parts of Semen sesami nigrum, 5 parts of spina date seed, 2 parts of peach kernel, 4 parts of mulberry leaf, rose
It is rare to spend 2 parts, 20 parts of 280 parts of yellow rice wine and honey.
By above-mentioned raw material, the preparation method for warding off Gu Dan provided using the present invention, Gu Dan is warded off in preparation：
S101：Cut into slices after sealwort is cleaned, be then placed in yellow rice wine, 45min is boiled at 100 DEG C；
S102：Add in the product that S101 is obtained, boiled at 80 DEG C after other raw material components in addition to honey are cleaned
30min；
S103：The product that S102 is obtained is crushed after 150 DEG C of drying to constant weights, obtains particle diameter less than or equal to 0.15mm
Dry powder；
S104：By the well mixed rear pill of the obtained products of S103 and honey, obtain warding off Gu Dan.
Embodiment six
The present embodiment provides one kind and wards off Gu Dan, raw material components by weight, including：25 parts of sealwort, 15 parts of radix polygonati officinalis, jujube
7.5 parts, 7.5 parts of matrimony vine, 7.5 parts of longan, 7.5 parts of Poria cocos, 7.5 parts of Chinese yam, 7.5 parts of Semen sesami nigrum, 2.5 parts of spina date seed, peach kernel 2.5
30 parts of part, 2.5 parts of mulberry leaf, 2.5 parts of rose, 250 parts of yellow rice wine and honey.
By above-mentioned raw material, the preparation method for warding off Gu Dan provided using the present invention, Gu Dan is warded off in preparation：
S101：Cut into slices after sealwort is cleaned, be then placed in yellow rice wine, 40min is boiled at 90 DEG C；
S102：Add in the product that S101 is obtained, endured again at 85 DEG C after other raw material components in addition to honey are cleaned
35min processed；
S103：The product that S102 is obtained is crushed after 120 DEG C of drying to constant weights, obtains particle diameter less than or equal to 0.15mm
Dry powder；
S104：By the well mixed rear pill of the obtained products of S103 and honey, obtain warding off Gu Dan.
Embodiment seven
The present embodiment provides one kind and wards off Gu Dan, raw material components by weight, including：20 parts of sealwort, 20 parts of radix polygonati officinalis, jujube
5 parts, 9 parts of matrimony vine, 5 parts of longan, 10 parts of Poria cocos, 6 parts of Chinese yam, 8 parts of Semen sesami nigrum, 1 part of spina date seed, 3 parts of peach kernel, 1 part of mulberry leaf, rose
Spend 5 parts, 10 parts of Ilex Latifolia Thunb, 8 parts of hawthorn, 1 part of Asian puccoon, 7 parts of water chestnut, 8 parts of the root of kudzu vine, 4 parts of wormwood, 40 parts of 200 parts of yellow rice wine and honey.
By above-mentioned raw material, the preparation method for warding off Gu Dan provided using the present invention, Gu Dan is warded off in preparation：
S101：Cut into slices after sealwort is cleaned, be then placed in yellow rice wine, 45min is boiled at 80 DEG C；
S102：Add in the product that S101 is obtained, boiled at 100 DEG C after other raw material components in addition to honey are cleaned
30min；
S103：The product that S102 is obtained is crushed after 100 DEG C of drying to constant weights, obtains particle diameter less than or equal to 0.15mm
Dry powder；
S104：By the well mixed rear pill of the obtained products of S103 and honey, obtain warding off Gu Dan.
Embodiment eight
The present embodiment provides one kind and wards off Gu Dan, raw material components by weight, including：30 parts of sealwort, 10 parts of radix polygonati officinalis, jujube
10 parts, 6 parts of matrimony vine, 8 parts of longan, 5 parts of Poria cocos, 10 parts of Chinese yam, 6 parts of Semen sesami nigrum, 5 parts of spina date seed, 2 parts of peach kernel, 4 parts of mulberry leaf, rose
It is rare spend 2 parts, 15 parts of Ilex Latifolia Thunb, 3 parts of hawthorn, 2 parts of Asian puccoon, 5 parts of water chestnut, 12 parts of the root of kudzu vine, 2 parts of wormwood, 280 parts of yellow rice wine and honey 20
Part.
By above-mentioned raw material, the preparation method for warding off Gu Dan provided using the present invention, Gu Dan is warded off in preparation：
S101：Cut into slices after sealwort is cleaned, be then placed in yellow rice wine, 45min is boiled at 100 DEG C；
S102：Add in the product that S101 is obtained, boiled at 80 DEG C after other raw material components in addition to honey are cleaned
30min；
S103：The product that S102 is obtained is crushed after 150 DEG C of drying to constant weights, obtains particle diameter less than or equal to 0.15mm
Dry powder；
S104：By the well mixed rear pill of the obtained products of S103 and honey, obtain warding off Gu Dan.
Embodiment nine
The present embodiment provides one kind and wards off Gu Dan, raw material components by weight, including：25 parts of sealwort, 15 parts of radix polygonati officinalis, jujube
7.5 parts, 7.5 parts of matrimony vine, 7.5 parts of longan, 7.5 parts of Poria cocos, 7.5 parts of Chinese yam, 7.5 parts of Semen sesami nigrum, 2.5 parts of spina date seed, peach kernel 2.5
Part, 2.5 parts of mulberry leaf, 2.5 parts of rose, 12 parts of Ilex Latifolia Thunb, 5 parts of hawthorn, 1.5 parts of Asian puccoon, 6 parts of water chestnut, 10 parts of the root of kudzu vine, wormwood 3
30 parts of part, 250 parts of yellow rice wine and honey.
By above-mentioned raw material, the preparation method for warding off Gu Dan provided using the present invention, Gu Dan is warded off in preparation：
S101：Cut into slices after sealwort is cleaned, be then placed in yellow rice wine, 40min is boiled at 90 DEG C；
S102：Add in the product that S101 is obtained, endured again at 85 DEG C after other raw material components in addition to honey are cleaned
35min processed；
S103：The product that S102 is obtained is crushed after 120 DEG C of drying to constant weights, obtains particle diameter less than or equal to 0.15mm
Dry powder；
S104：By the well mixed rear pill of the obtained products of S103 and honey, obtain warding off Gu Dan.
Embodiment ten
The present embodiment provides one kind and wards off Gu Dan, raw material components by weight, including：20 parts of sealwort, 20 parts of radix polygonati officinalis, jujube
5 parts, 9 parts of matrimony vine, 5 parts of longan, 10 parts of Poria cocos, 6 parts of Chinese yam, 8 parts of Semen sesami nigrum, 1 part of spina date seed, 3 parts of peach kernel, 1 part of mulberry leaf, rose
Spend 5 parts, 10 parts of Ilex Latifolia Thunb, 8 parts of hawthorn, 1 part of Asian puccoon, 7 parts of water chestnut, 8 parts of the root of kudzu vine, 4 parts of wormwood, 40 parts of 200 parts of yellow rice wine and honey.
By above-mentioned raw material, the preparation method for warding off Gu Dan provided using the present invention, Gu Dan is warded off in preparation：
S101：Cut into slices after sealwort is cleaned, be then placed in yellow rice wine, 45min is boiled at 80 DEG C；
S102：Add in the product that S101 is obtained, boiled at 100 DEG C after other raw material components in addition to honey are cleaned
30min；
S103：The product that S102 is obtained is crushed after 100 DEG C of drying to constant weights, obtains particle diameter less than or equal to 0.15mm
Dry powder；
After dry powder and yellow rice wine are well mixed, 5h are stood at 20 DEG C, 80min, regulation pH value to 9.0 are then heated at 60 DEG C
Afterwards, 10min is heated at 85 DEG C, by obtained mixture in 120 DEG C of drying to constant weight；Wherein, yellow rice wine in S101 and S103
Ratio is 2.5:1；
S104：By the well mixed rear pill of the obtained products of S103 and honey, obtain warding off Gu Dan.
Embodiment 11
The present embodiment provides one kind and wards off Gu Dan, raw material components by weight, including：30 parts of sealwort, 10 parts of radix polygonati officinalis, jujube
10 parts, 6 parts of matrimony vine, 8 parts of longan, 5 parts of Poria cocos, 10 parts of Chinese yam, 6 parts of Semen sesami nigrum, 5 parts of spina date seed, 2 parts of peach kernel, 4 parts of mulberry leaf, rose
It is rare spend 2 parts, 15 parts of Ilex Latifolia Thunb, 3 parts of hawthorn, 2 parts of Asian puccoon, 5 parts of water chestnut, 12 parts of the root of kudzu vine, 2 parts of wormwood, 280 parts of yellow rice wine and honey 20
Part.
By above-mentioned raw material, the preparation method for warding off Gu Dan provided using the present invention, Gu Dan is warded off in preparation：
S101：Cut into slices after sealwort is cleaned, be then placed in yellow rice wine, 45min is boiled at 100 DEG C；
S102：Add in the product that S101 is obtained, boiled at 80 DEG C after other raw material components in addition to honey are cleaned
30min；
S103：The product that S102 is obtained is crushed after 150 DEG C of drying to constant weights, obtains particle diameter less than or equal to 0.15mm
Dry powder；
By dry powder and yellow rice wine it is well mixed after, stand 6h at 30 DEG C, then heat 90min at 70 DEG C, regulation pH value to
After 10.5,15min is heated at 90 DEG C, by obtained mixture in 135 DEG C of drying to constant weight；Wherein, the Huang in S101 and S103
The ratio of wine is 3:1；
S104：By the well mixed rear pill of the obtained products of S103 and honey, obtain warding off Gu Dan.
Embodiment 12
The present embodiment provides one kind and wards off Gu Dan, raw material components by weight, including：25 parts of sealwort, 15 parts of radix polygonati officinalis, jujube
7.5 parts, 7.5 parts of matrimony vine, 7.5 parts of longan, 7.5 parts of Poria cocos, 7.5 parts of Chinese yam, 7.5 parts of Semen sesami nigrum, 2.5 parts of spina date seed, peach kernel 2.5
Part, 2.5 parts of mulberry leaf, 2.5 parts of rose, 12 parts of Ilex Latifolia Thunb, 5 parts of hawthorn, 1.5 parts of Asian puccoon, 6 parts of water chestnut, 10 parts of the root of kudzu vine, wormwood 3
30 parts of part, 250 parts of yellow rice wine and honey.
By above-mentioned raw material, the preparation method for warding off Gu Dan provided using the present invention, Gu Dan is warded off in preparation：
S101：Cut into slices after sealwort is cleaned, be then placed in yellow rice wine, 40min is boiled at 90 DEG C；
S102：Add in the product that S101 is obtained, endured again at 85 DEG C after other raw material components in addition to honey are cleaned
35min processed；
S103：The product that S102 is obtained is crushed after 120 DEG C of drying to constant weights, obtains particle diameter less than or equal to 0.15mm
Dry powder；
By dry powder and yellow rice wine it is well mixed after, stand 5.5h at 25 DEG C, then heat 85min at 65 DEG C, regulation pH value to
After 9.5,12min is heated at 90 DEG C, by obtained mixture in 125 DEG C of drying to constant weight；Wherein, the yellow rice wine in S101 and S103
Ratio be 2.8:1；
S104：By the well mixed rear pill of the obtained products of S103 and honey, obtain warding off Gu Dan.
Comparative example one
This comparative example provides one kind and wards off Gu Dan, raw material components by weight, including：25 parts of sealwort, 15 parts of radix polygonati officinalis, jujube
7.5 parts, 7.5 parts of matrimony vine, 7.5 parts of longan, 7.5 parts of Poria cocos, 7.5 parts of Chinese yam, 7.5 parts of Semen sesami nigrum, 2.5 parts of spina date seed, peach kernel 2.5
Part, 2.5 parts of mulberry leaf, 2.5 parts of rose, 12 parts of Ilex Latifolia Thunb, 5 parts of hawthorn, 1.5 parts of Asian puccoon, 6 parts of water chestnut, 10 parts of the root of kudzu vine, yellow rice wine
250 parts and 30 parts of honey.
Preparation method be the same as Example 12.
Comparative example two
This comparative example provides one kind and wards off Gu Dan, raw material components by weight, including：25 parts of sealwort, 15 parts of radix polygonati officinalis, jujube
7.5 parts, 7.5 parts of matrimony vine, 7.5 parts of longan, 7.5 parts of Poria cocos, 7.5 parts of Chinese yam, 7.5 parts of Semen sesami nigrum, 2.5 parts of spina date seed, peach kernel 2.5
Part, 2.5 parts of mulberry leaf, 2.5 parts of rose, 1.5 parts of Asian puccoon, 6 parts of water chestnut, 10 parts of the root of kudzu vine, 3 parts of wormwood, 250 parts of yellow rice wine and honey 30
Part.
Preparation method be the same as Example 12.
Comparative example three
This comparative example provides one kind and wards off Gu Dan, raw material components be the same as Example 12.
By above-mentioned raw material, the preparation method for warding off Gu Dan provided using the present invention, Gu Dan is warded off in preparation：
S101：Cut into slices after sealwort is cleaned, be then placed in yellow rice wine, 40min is boiled at 90 DEG C；
S102：Add in the product that S101 is obtained, endured again at 85 DEG C after other raw material components in addition to honey are cleaned
35min processed；
S103：The product that S102 is obtained is crushed after 120 DEG C of drying to constant weights, obtains particle diameter less than or equal to 0.15mm
Dry powder；
After dry powder and yellow rice wine are well mixed, 5.5h are stood at 25 DEG C, 85min, regulation pH value to 7 are then heated at 65 DEG C
Afterwards, 12min is heated at 90 DEG C, by obtained mixture in 125 DEG C of drying to constant weight；Wherein, yellow rice wine in S101 and S103
Ratio is 2.8:1；
S104：By the well mixed rear pill of the obtained products of S103 and honey, obtain warding off Gu Dan.
Comparative example four
This comparative example provides one kind and wards off Gu Dan, raw material components be the same as Example 12.
By above-mentioned raw material, the preparation method for warding off Gu Dan provided using the present invention, Gu Dan is warded off in preparation：
S101：Cut into slices after sealwort is cleaned, be then placed in yellow rice wine, 40min is boiled at 90 DEG C；
S102：Add in the product that S101 is obtained, endured again at 85 DEG C after other raw material components in addition to honey are cleaned
35min processed；
S103：The product that S102 is obtained is crushed after 120 DEG C of drying to constant weights, obtains particle diameter less than or equal to 0.15mm
Dry powder；
By dry powder and yellow rice wine it is well mixed after, stand 5.5h at 25 DEG C, then heat 85min at 65 DEG C, regulation pH value to
After 11.5,12min is heated at 90 DEG C, by obtained mixture in 125 DEG C of drying to constant weight；Wherein, the Huang in S101 and S103
The ratio of wine is 2.8:1；
S104：By the well mixed rear pill of the obtained products of S103 and honey, obtain warding off Gu Dan.
Gu Dan is warded off by what the embodiment of the present invention one to embodiment 12 was prepared, and it is prepared by comparative example one to comparative example four
What is obtained wards off Gu Dan, by function assessment experiment come its effect of system evaluation.
1st, effect of weight reducing
(1) animal experiment
Test method：With healthy adult rat 180,18 groups are randomly divided into：Negative control group, high-fat adiposity control group
And administration group, every group of 10 animals.Before experiment after check weighing, tail blood is taken to survey serum total cholesterol (TC), triglycerides (TG) and height
Density lipoprotein (HDL-C).Other each groups give high lipid food and feed (high lipid food in addition to negative control group is to normal diet
Formula：78.8% basal feed, 1% cholesterol, 10% yolk powder, 10% lard and 0.2% cholate).Administration group gavage is given
What be the same as Example or comparative example were not prepared wards off Gu Dan, and two control groups (negative control group and high-fat adiposity control group) gavage is given
The deionized water of same volume is given, tested material 28d is given by 2g/1kgBW gavages.Once a day, weigh weekly once.Examination
Fasting 16h before end is tested, after weighing, broken end takes blood to survey serum total cholesterol (TC), triglycerides (TG) and high density lipoprotein level
White cholesterol (HDL-C), takes body fat (testis and perinephric fat pad) to weigh, and calculate body fat/end weight ratio while cutting open the belly.
Result of the test：All test datas carry out statistical analysis using the softwares of SPSS 17.0.Increased weight, body fat are wet
Weight and body fat/end weight ratio situation are specifically shown in Table 1.
Influence situation of the table 1 to rat body weight, body fat weight in wet base and body fat/end weight ratio
Influence situation to rat fat index is specifically shown in Table 2.
Influence situation of the table 2 to rat fat index
(2) clinical test
Test method：1300 simple obesity volunteers (body weight is in 100~150kg) are recruited, 13 groups are randomly divided into, often
100 (each 50 of men and women) of group, what the embodiment of the present invention four to embodiment 12 on probation was prepared respectively wards off Gu Dan, and contrast
Example one wards off Gu Dan to what comparative example four was prepared.Eating method：Three times a day, daily 15g, early, neutralization dinner is distinguished after the meal
Edible 5g, it 7 days is a course for the treatment of to eat, and is eaten 28 days.Body weight before and after all volunteers are tested is measured and remembered respectively
Record (empty stomach 4h before measurement), obtained result is as shown in table 3 below.
The volunteer's changes of weight situation of table 3
2nd, effect of lowering blood sugar
Test method：According to the Ministry of Public Health《Health food is examined and assessment technique specification (2003 editions)》Regulation carries out animal work(
Can experiment.The male mouse of kunming 150 of 4 week old is chosen, normal feed 1 week is adapted to after environment in animal feeding room, is surveyed small
Mouse body weight, blood glucose value.It is normal to feed by wherein 10 mouse as blank control group, normal diet is given all the time, by remaining
Streptozotocin (STZ) is injected intraperitoneally according to 70mg/kg dosage in 140 mouse, blood glucose value is determined after 72 hours, with blood glucose value
It is into mould animal for 10-25mmol/L mouse, high sugar feed is given all the time into mould animal.Choose 130 therein small into mould
Mouse, 13 groups are classified as according to blood glucose value, and approach every group of average blood sugar value, every group 10, are added as blank control group
Mouse, 15 groups altogether, 15 groups are respectively：Blank control group, model group：Give diabetic mice gavage physiological saline 0.3ml/d；
Ward off the red experimental group of paddy：Made to the diabetic mice gavage embodiment of the present invention four to embodiment 12, comparative example one to comparative example four
Gu Dan 25mg/kg/d are warded off for what is obtained.Daily gastric infusion 1 time, continuous 28 days, surveys blood glucose value after fasting 10h.
Result of the test：All test datas carry out statistical analysis, concrete outcome such as table 4 below institute using SPSS17.0 softwares
Show.
Influence of the table 4 to diabetes mice model
3rd, effect of hypotensive
Test method：Hyperpietic 1200 is recruited, the systolic pressure average value of patient is that (scope is 160 to 165mm mercury column
~170mm mercury column), patient is divided into 12 groups, every group 100；The embodiment of the present invention one to embodiment 12 is tried out respectively to make
Gu Dan is warded off for what is obtained, and comparative example one wards off Gu Dan to what comparative example four was prepared.Eating method：Three times a day, daily
15g, early, neutralization dinner eats 5g respectively after the meal, and it 7 days is a course for the treatment of to eat, and is eaten 28 days.Edible for patients is warded off Gu Danqian's
Systolic pressure measures (survey three times average) and recorded, and edible for patients is warded off to the systolic pressure after Gu Dan 28 days and measured
(survey three times and average) is simultaneously recorded, and statistical analysis is carried out to result.Wherein, curative effect situation criterion is, effective：Systolic pressure
Compared with decline 20~30mm mercury column before edible health mushroom juice；Effectively：Systolic pressure is compared with decline 0~20mm mercury before edible health mushroom juice
Post；It is invalid：Systolic pressure declines without any, remains unchanged substantially.As a result it is as shown in table 5 below.
Table 5 wards off immunoregulation functions of the Gu Dan to hyperpietic
4th, toxicity test
The small white mouse 60 (each 30 of male and female) for selecting body weight to be 18~22g, is divided into 12 groups, each 5 of every group of male and female take respectively
Gu Dan is warded off with what the embodiment of the present invention one to embodiment 12 was prepared, dosage is 25g/kg, can be added in small white mouse
In food, continuous 10 days.During edible and when stopping edible latter 1 week, observation white mouse growth conditions and activity and diet identify blood
, blood biochemical analysis, organ tissue structure and routine urinalysis etc..As a result the health existence of all small white mouses is found, without any poison
Side effect；Anatomic observation blood picture, liver function, each organs and tissues state, are compared indifference with normal small white mouse.It is demonstrated experimentally that this
What invention was provided wards off that Gu Dan is nontoxic, and edible safety is reliable.
5th, other clinical trial results
Subjects：From in April, 2013 in April, 2016, the Gu Dan that wards off prepared using the embodiment of the present invention six is adjusted
The obese diabetes crowd that reason 100 suffers from hypertension, the oldest person 73 years old, age reckling 30 years old, average age 48 years old.
Nursing one's health object includes hypertension, diabetes and obesity.
Opsonizing method：Three times a day, 5g is eaten every time, and it 7 days is a course for the treatment of to eat.
Conditioning standard：It is effective：Symptom and sign mitigate, and other Index for examination are obviously improved；It is invalid：Symptom and sign do not have
Change, other Index for examination are not improved.
Nurse one's health result：By the conditioning observation of a course for the treatment of, 98 have effective result, and 2 invalid, and total effective rate is
98%.
It should be noted that situation about being enumerated to embodiment 12 except above-described embodiment one, from other raw material groups
Distribution ratio and preparation method parameter are also feasible.
The technical scheme that the present invention is provided, with following beneficial effect：(1) present invention is by using sealwort, radix polygonati officinalis, big
Jujube, matrimony vine, longan, Poria cocos, Chinese yam, Semen sesami nigrum, yellow rice wine and honey and other substances are as raw material, and what is prepared wards off Gu Dan with aobvious
The effect of weight reducing of work, and instant effect, while having hypoglycemic and hypotensive effect concurrently；(2) what the present invention was prepared wards off Gu Dan
, can be with long-term taking, rich in several mineral materials and vitamin in the absence of specific peculiar smell, in good taste, the red ball being made can be with
Directly take, similarly suitable the elderly is edible；(3) what the present invention was prepared wards off the red safe without toxic side effect of paddy, to body
It is harmless；(4) preparation method for warding off Gu Dan that the present invention is provided is simple, and production cost is low.
It should be noted that unless otherwise indicated, technical term or scientific terminology used in this application should be this hair
The ordinary meaning that bright one of ordinary skill in the art are understood.Unless specifically stated otherwise, otherwise illustrate in these embodiments
Part and relative step, numerical expression and the numerical value of step are not limit the scope of the invention.It is illustrated and described herein
In all examples, unless otherwise prescribed, any occurrence should be construed as merely exemplary, not as limitation, because
This, other examples of exemplary embodiment can have different values.
Finally it should be noted that：Various embodiments above is merely illustrative of the technical solution of the present invention, rather than its limitations；To the greatest extent
The present invention is described in detail with reference to foregoing embodiments for pipe, it will be understood by those within the art that：Its according to
The technical scheme described in foregoing embodiments can so be modified, or which part or all technical characteristic are entered
Row equivalent substitution；And these modifications or replacement, the essence of appropriate technical solution is departed from various embodiments of the present invention technology
The scope of scheme, it all should cover among the scope of the present invention.
Claims (10)
1. one kind wards off Gu Dan, it is characterised in that raw material components by weight, including：
20~30 parts of sealwort, 10~20 parts of radix polygonati officinalis, 5~10 parts of jujube, 6~9 parts of matrimony vine, 5~8 parts of longan, 5~10 parts of Poria cocos,
20~40 parts of 6~10 parts of Chinese yam, 6~8 parts of Semen sesami nigrum, 200~280 parts of yellow rice wine and honey.
2. according to claim 1 ward off Gu Dan, it is characterised in that the raw material components also include：
2~5 parts of 1~5 part of spina date seed, 2~3 parts of peach kernel, 1~4 part of mulberry leaf and rose.
3. according to claim 2 ward off Gu Dan, it is characterised in that raw material components by weight, including：
25 parts of sealwort, 15 parts of radix polygonati officinalis, 7.5 parts of jujube, 7.5 parts of matrimony vine, 7.5 parts of longan, 7.5 parts of Poria cocos, 7.5 parts of Chinese yam, black sesame
30 parts of 7.5 parts of fiber crops, 2.5 parts of spina date seed, 2.5 parts of peach kernel, 2.5 parts of mulberry leaf, 2.5 parts of rose, 250 parts of yellow rice wine and honey.
4. according to claim 2 ward off Gu Dan, it is characterised in that the raw material components also include：
2~4 parts of 10~15 parts of Ilex Latifolia Thunb, 3~8 parts of hawthorn, 1~2 part of Asian puccoon, 5~7 parts of water chestnut, 8~12 parts of the root of kudzu vine and wormwood.
5. according to claim 4 ward off Gu Dan, it is characterised in that raw material components by weight, including：
25 parts of sealwort, 15 parts of radix polygonati officinalis, 7.5 parts of jujube, 7.5 parts of matrimony vine, 7.5 parts of longan, 7.5 parts of Poria cocos, 7.5 parts of Chinese yam, black sesame
7.5 parts of fiber crops, 2.5 parts of spina date seed, 2.5 parts of peach kernel, 2.5 parts of mulberry leaf, 2.5 parts of rose, 12 parts of Ilex Latifolia Thunb, 5 parts of hawthorn, Asian puccoon
30 parts of 3 parts of 1.5 parts, 6 parts of water chestnut, 10 parts of the root of kudzu vine and wormwood, 250 parts of yellow rice wine and honey.
6. the preparation method for warding off Gu Dan described in claim any one of 1-5, it is characterised in that comprise the following steps：
S101：Cut into slices after sealwort is cleaned, be then placed in yellow rice wine and boil；
S102：Add in the product that the S101 is obtained, boil again after other raw material components in addition to honey are cleaned；
S103：The obtained products of the S102 are dried into constant weight crushing, dry powder is obtained；
S104：By the well mixed rear pill of the obtained products of the S103 and honey, obtain warding off Gu Dan.
7. the preparation method according to claim 6 for warding off Gu Dan, it is characterised in that：
In the S101 and the S102, the temperature boiled is 80~100 DEG C, and the time boiled is 30~45min.
8. the preparation method according to claim 6 for warding off Gu Dan, it is characterised in that：
In the S103, the temperature of the drying is 100~150 DEG C.
9. the preparation method according to claim 6 for warding off Gu Dan, it is characterised in that：
In the S103, the particle diameter of the dry powder after the crushing is less than or equal to 0.15mm.
10. the preparation method according to claim 6 for warding off Gu Dan, it is characterised in that：
In the S103, also comprise the following steps：After the dry powder and yellow rice wine are well mixed, 5~6h are stood at 20~30 DEG C,
Then heated at 60~70 DEG C after 80~90min, regulation pH value to 9.0~10.5,10~15min is heated at 85~90 DEG C, will
Obtained mixture is in 120~135 DEG C of drying to constant weight；Wherein, the ratio of the S101 and the yellow rice wine in the S103 is
(2.5~3):1.
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| CN110772596A (en) * | 2019-11-28 | 2020-02-11 | 西安荷默奇医药科技有限公司 | A functional food, TAOHUAJING, prepared from Chinese medicinal materials, and its quality control and component analysis method |
| CN111184814A (en) * | 2020-03-25 | 2020-05-22 | 明昌平 | A Chinese medicinal composition for treating obesity and preparation method thereof |
| CN111346183A (en) * | 2020-04-11 | 2020-06-30 | 蒋磊 | Celery seed antihypertensive and lipid-lowering medicine and preparation method thereof |
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Application publication date: 20170721 |