CN106722258A - A kind of astaxanthin colla corii asini cake and preparation method thereof - Google Patents
A kind of astaxanthin colla corii asini cake and preparation method thereof Download PDFInfo
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- CN106722258A CN106722258A CN201611031762.3A CN201611031762A CN106722258A CN 106722258 A CN106722258 A CN 106722258A CN 201611031762 A CN201611031762 A CN 201611031762A CN 106722258 A CN106722258 A CN 106722258A
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- parts
- astaxanthin
- powder
- root
- corii asini
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Classifications
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a kind of astaxanthin colla corii asini cake and preparation method thereof.The astaxanthin colla corii asini cake, is made with astaxanthin powder, donkey-hide gelatin, Semen sesami nigrum, walnut kernel, rock sugar, yellow rice wine, jujube, longan, matrimony vine, raisins, rose powder, peppermint, lotus nut, Radix Angelicae Sinensis, the root of herbaceous peony, the root of kudzu vine, Gorgon fruit, sweet osmanthus, lamiophlomis rotata, Cynanchum glaucescens, coix seed, milk thistle, rhizoma cyperi, Asiatic plantain, emblic, the root of Chinese clematis by raw material.The astaxanthin colla corii asini cake, take full advantage of the nutritional ingredient and medium-height grass the effective elements of the medicine contained by natural food, in addition to it common are beneficial composition containing donkey-hide gelatin etc., also contain various Chinese herbal medicine effective ingredientses, all raw material effect collaborations, outside the effects such as with regulation biological rhythm, antioxidant and anti-aging, enhancing immune function of human body, moreover it is possible to effectively regulation sleep, realize with health food to replace conventional medicament.
Description
Technical field
The present invention relates to a kind of astaxanthin colla corii asini cake and preparation method thereof.
Background technology
With the continuous quickening of rhythm of life, people can usually be faced work overloadingly for a long time, thought pressure is excessive, diet
It is irregular, the problems such as lack exercise, this can cause people to be chronically at sub-health state, so that endocrinopathy, sleep quality
The situations such as reduction, immunity degradation.At present, increasing people is had a strong impact on by having a sleepless night and hypoimmunity is perplexed
Routine work and life.Insomnia, sleep shakiness and hypoimmunity have turned into one of main public health problem of China.
At present, for insomnia and the problem of hypoimmunity, drug therapy is typically with, though immediate effect is pretty good,
But there is different degrees of side effect, and patient is produced dependence to medicine.
The content of the invention
The present invention is in order to make up the deficiencies in the prior art, there is provided a kind of shrimp for improving the health care of sleep, strengthening body immunity is blue or green
Plain colla corii asini cake and preparation method thereof.
The present invention is achieved through the following technical solutions：
A kind of astaxanthin colla corii asini cake, its active component is prepared from the following raw materials in parts by weight：8~12 parts of astaxanthin powder,
5~8 parts of donkey-hide gelatin, 3~6 parts of Semen sesami nigrum, 5~9 parts of walnut kernel, 3~5 parts of rock sugar, 13~16 parts of yellow rice wine, 4~6 parts of jujube, longan 5
~7 parts, 4~7 parts of matrimony vine, 4~6 parts of raisins, 3~5 parts of rose powder, 4~7 parts of peppermint, 1.5~2.2 parts of lotus nut, Radix Angelicae Sinensis 4
~7 parts, 5~7 parts of the root of herbaceous peony, 5~8 parts of the root of kudzu vine, 4~6 parts of Gorgon fruit, 3~5 parts of sweet osmanthus, 3~4 parts of lamiophlomis rotata, 4~6 parts of Cynanchum glaucescens, the heart of a lotus seed
3~5 parts of the seed of jog's tears, 3~6 parts of milk thistle, 3~5 parts of rhizoma cyperi, 4~7 parts of Asiatic plantain, 2~3 parts of emblic, 3~7 parts of the root of Chinese clematis.
Preferably, the parts by weight of each active component are：10 parts of astaxanthin powder, 7 parts of donkey-hide gelatin, 5 parts of Semen sesami nigrum, walnut kernel 7
Part, 4 parts of rock sugar, 15 parts of yellow rice wine, 5 parts of jujube, 6 parts of longan, 6 parts of matrimony vine, 5 parts of raisins, 4 parts of rose powder, 6 parts of peppermint, lotus seeds
1.9 parts of the heart, 6 parts of Radix Angelicae Sinensis, 6 parts of the root of herbaceous peony, 7 parts of the root of kudzu vine, 5 parts of Gorgon fruit, 4 parts of sweet osmanthus, 3.5 parts of lamiophlomis rotata, 5 parts of Cynanchum glaucescens, coix seed 4
Part, 5 parts of milk thistle, 4 parts of rhizoma cyperi, 6 parts of Asiatic plantain, 2.5 parts of emblic, 5 parts of the root of Chinese clematis.
Described astaxanthin powder is Astaxanthin In Haematococcus Pluvialis powder.
A kind of preparation method of astaxanthin colla corii asini cake, using following steps：
(1) Radix Angelicae Sinensis, the root of herbaceous peony, the root of kudzu vine, rhizoma cyperi and the root of Chinese clematis are cut into slices, are placed in marmite, add 5~7 times of Radix Angelicae Sinensis, the root of herbaceous peony,
The pure water of the root of kudzu vine, rhizoma cyperi and root of Chinese clematis quality sum, after soaking 4~6 hours, adds lotus nut and Gorgon fruit, adds water to cook twice,
Filtered after decocting 40~60 minutes every time, merge filtrate twice；
(2) peppermint, sweet osmanthus, lamiophlomis rotata and Asiatic plantain are made meal, water extraction twice, after boiling 1 hour every time during water extraction
Filtering, merges filtrate twice, to being well mixed after rose powder is added in merging filtrate, mass concentration is added after standing 3~4 hours
It is 70%~75% alcohol, is sufficiently stirred for, filter, removal precipitation is dense by the solution after removing precipitation at 35 DEG C~40 DEG C
The thick paste that relative density is 1.2~1.4 is reduced to, thick paste then be dry, pulverize into fine powder below 60 DEG C, cross 60~80 mesh
Sieve, obtains powder；
(3) Cynanchum glaucescens, coix seed, milk thistle and emblic are crushed, crosses 40~60 mesh sieves, mixed, by the mixing after mixing
Material is placed in Chinese medicine extracting tank, to 8~10 times of water of mixed material quality are added in Chinese medicine extracting tank, is extracted twice, every time
Filtered after extracting 60~80 minutes, merge filtrate twice, the filtrate after merging is stood overnight, filtered, add step (1) gained
Filtrate, is well mixed, and the thick paste that relative density is 1.25~1.35 is concentrated at 38 DEG C~41 DEG C, is added in gained thick paste
Mass concentration is 55%~60% ethanol solution, to ethanol mass concentration be 29%~36% when stop addition, stirring, will
Plus after the thick paste after ethanol solution stands overnight again, ethanol is recovered under reduced pressure, and step (2) gained powder is added, it is well mixed, will
What is obtained after mixing is placed in vacuum drying chamber without alcohol condensed cream, and dry extract is dried at a temperature of 55 DEG C~65 DEG C, standby；
(4) in one layer of preservative film of surfacing shakedown of stainless steel pallet, on preservative film surface, one layer of sesame oil of brush, standby；
(5) Semen sesami nigrum is eluriated twice, is dried, the Semen sesami nigrum after drying is placed in frying pan, slow fire is slowly heated not
Disconnected stirring, fries to Semen sesami nigrum slightly fragrance and is taken the dish out of the pot when being extruded and easily crushed with thumb and forefinger, is cooled to room temperature, obtains frying black
Sesame, it is standby；
(6) walnut kernel is placed in another frying pan, when the temperature that slow fire is slowly heated to walnut kernel is 38 DEG C~42 DEG C, text
Fire turns underwear when moderate heat continuation stir-fry extremely gently twists with the fingers walnut kernel with hand and easily comes off, and ceases fire, and takes the dish out of the pot, and is down to room temperature, obtains frying walnut kernel,
It is standby；
(7) jujube and longan are enucleated, are placed in baking box, baked 5~10 minutes at 160 DEG C~180 DEG C, taken out, cooled
After be placed in medicinal herb grinder, add step (6) gained frying walnut kernel, crush, cross 80~120 mesh sieves, obtain powder；
(8) donkey-hide gelatin is placed in powder beater and is crushed, cross 100~140 mesh sieves, the gelatin powder after sieving is placed in non-iron ware
In, add by the rock sugar after crushing, place 2~3 days, yellow rice wine is added, Steam by water bath in pot is put into, big fire is boiled to after boiling and turns text
Fiery steaming slowly, endures and adds matrimony vine and raisins when flag is hung, and stirs, and after continuing the slow steaming of slow fire 25~35 minutes, adds step
(3) gained dry extract and step (7) gained powder, stir, and after continuing the slow steaming of slow fire 15~20 minutes, add astaxanthin powder
With the frying Semen sesami nigrum obtained by step (5), stir 8~10 minutes clockwise, Guan Huo is taken the dish out of the pot, and the product after taking the dish out of the pot is poured on into step
Suddenly in (4) ready stainless steel pallet, flatten, cool to room temperature, freezed 15~25 hours at a temperature of -4 DEG C~-8 DEG C,
Stripping and slicing is carried out with every piece of quality 28g~30g, is packed, obtain final product the astaxanthin colla corii asini cake.
It refers to that donkey-hide gelatin slabbing is hung on shovel, in a face flag when containing some with wood shovel to lift that flag is hung described in step (8)
Shape slowly falls down, and the concentration of paste is 1.46g/cm when hanging flag3~1.49g/cm3。
Astaxanthin powder in step (8) is Astaxanthin In Haematococcus Pluvialis powder.
Usage and dosage：It is edible daily to eat one piece every time twice, eaten within 1 hour with after supper before meals respectively at early, take
When more drink warm water.
The pharmaceutical characteristic of each active component of the present invention is as follows：
Astaxanthin powder：Astaxanthin belongs to a kind of fat-soluble and water miscible pigment.Rain is used to give birth to red ball in the present invention
Algae astaxanthin, extracts from haematococcus pluvialis, and Determination of Astaxanthin in Haematococcus Pluvialis content is 1.5%-3.0%, and astaxanthin has powerful
Inoxidizability.Its common health-care efficacy：Protection eye and central nervous system；Ultraviolet radiation preventing；Prevention of cardiovascular disease；
Strengthen immunity；Alleviate sports fatigue, enhancing human body energy metabolism；The anti-infective characteristic of anti-inflammatory；Suppress tumour；Suppress diabetogenous nephrosis
Disease.
Donkey-hide gelatin：It is sweet, it is mild-natured.Return lung, liver and kidney channel.Donkey-hide gelatin is the skin of equine species donkey, through consolidating that decoction, concentration are made
Body glue, is traditional nourishing top grade, panacea of enriching blood.With tonifying the blood and arrest bleeding, nourshing Yin and drynsessmoistening prescription the effects such as, medicine-food two-purpose can enrich blood foster
Blood, beauty face-whitening-nourishing, anti-aging, antifatigue, enhance immunity.
Semen sesami nigrum：It is sweet, it is mild-natured.Semen sesami nigrum is the black seeds of Pedaliaceae sesame, containing substantial amounts of fat and protein,
Also contain the nutritional ingredients such as carbohydrate, VitAVitE, lecithin, calcium, iron, chromium.With nourishing liver and kidney, beneficial blood ease constipation, lead to
Just the function of breast, is led to.
Walnut kernel：Phosphatide in walnut, has excellent health functions to cranial nerve.Walnut oil contains unrighted acid, has
Prevent and treat effect of artery sclerosis.Contain the indispensable trace elements of human body such as zinc, manganese, chromium in walnut kernel.The antibechic of walnut kernel
Antiasthmatic effect is also fairly obvious, and, the prevention cardiovascular to protection such as arginine, oleic acid, polyphenoils contained in walnut
Coronary heart disease, apoplexy, senile dementia etc. are that quite have benifit.
Rock sugar：It is sweet, mild-natured.Return lung, the spleen channel.Rock sugar is the crystallization reproduced goods of granulated sugar, can make medicinal, can also make candy food
With.Rock sugar can increase sugariness, neutralize unnecessary acidity, and have functions that to reduce internal heat.With tonifying middle-Jiao and Qi and stomach moistening lung, support
Yin and promoting production of body liquid, the effect for moistening the lung and relieve the cough.For the dryness of the lung, the deficiency syndrome of the lung, chill fatigue caused by cough and asthma, infantile malaria, dysentery with vomiting, aphtha,
Acute toothache.
Yellow rice wine：Yellow rice wine be a class with rice, milled glutinous broomcorn millet, corn, millet, wheat etc. as primary raw material, using boiling, with wine
Bent, saccharification, fermentation, the brewed wine for squeezing, filter, decocting wine, store, blend.Contain polyphenol, melanoidin, glutathione etc.
Physiologically active ingredient, with removing free radical, prevention of cardiovascular disease, anticancer, anti-ageing physiological function of waiting for a long time.Yellow rice wine contains abundant
Nutrition, including several human bodies itself can not synthesize the amino acid that must rely on food intake.
Jujube：Sweet, micro- sweet, slightly warm in nature.Jujube for Rhamnaceae plant jujube fruit, containing protein, fat, carbohydrate,
The abundant nutrition such as organic acid, vitamin A, vitamin C, micro-calcium several amino acids.With invigorating the spleen and benefiting qi, enriching yin mends
Sun, effect of nourishing blood and tranquilization.Jujube can improve body immunity, and can suppress cancer cell.Pharmacological research finds that jujube can promote
The generation of leucocyte, reduce serum cholesterol improves seralbumin, protects liver, also containing cancer cell is suppressed in jujube, very
Material of the cancer cell to normal cell turnover can extremely be made.
Longan：It is sweet, it is warm in nature.The thoughts of returning home, the spleen channel.Longan is the aril of sapindaceous plant longan, contains various nutrition
Material, has functions that blood-enriching tranquillizing, brain tonic and intelligence development, takes a tonic or nourishing food to build up one's health heart spleen.Thin and weak for consumptive disease, insomnia is forgetful, palpitation with fear, palpitation.
Research finds that longan is to the inhibiting rate of uterine cancer cells more than 90%.
Matrimony vine：It is sweet, mild-natured.Return liver, kidney, lung channel.Matrimony vine is the dry mature fruit of plant of Solanaceae lycium barbarum.Containing Chinese holly
Qi polysaccharide, glycine betaine, atropine, hyoscyamine, zeaxanthine, wintercherry red pigment, kryptoxanthin, Scopoletin, carrotene, core
Flavine, nicotinic acid, vitamin etc..There is nourishing the liver, nourshing kidney, moistening lung.For caused by liver and kidney deficiency, have a dizzy spell, visually unclear, waist
Knees soreness, impotence and seminal emission, cough due to consumptive disease is quenched one's thirst and draws drink.
Raisins：Raisins are the fruits of sun cured or the grape for drying in the shade.Iron and calcium content ten in raisins
It is point abundant, can replenishing blood and vital energy, warm kidney, help improve anaemia, decrease of platelet.Raisins contain a large amount of glucose, nutritious to cardiac muscle
Effect, contributes to the rehabilitation of patients with coronary heart disease.Raisins also contain several mineral materials and vitamin, amino acid, and often to eat is to nerve
Weak and fatigue person has preferable benefiting action.
Rose powder：After rose powder is rose through membrane technology purification, concentration, vacuum freeze drying is obtained, and fully keeps
The nutritional ingredient of rose, color effects etc..Rich in amino acid needed by human body, protein, organic acid vitamin C, a large amount of natural
Pigment and several mineral materials, the acid of the water rose of Sharon；And containing three big abundant rare elements：Natural anthocyanidin, natural fiavanoids are plain, natural total
Polyphenol.
Peppermint：Taste is pungent, it is cool in nature.Return lung, Liver Channel.Peppermint is the dry aerial parts of Labiatae mint peppermint.Contain
Volatile oil 0.8~1%, main component is menthol in volatile oil, is secondly menthones, also containing menthyl acetate, amphene, lemon
Alkene, isomenthone, firpene, piperitenone, resin and a small amount of tannin, Rosmarinic acid etc..With dispelling wind-heat, refresh oneself, promoting eruption
Effect.For anemopyretic cold, wind-warm syndrome is from the beginning of headache, hot eyes, larynx numbness, aphtha, rubella, measles, Breast bilges frowsty about.
Lotus nut：Bitter, it is cold in nature.The thoughts of returning home, kidney channel.Lotus nut is the green embryo in the middle of the mature seed of nymphaeaceae plant lotus
Root (lotus nut).There is clearing away the heart fire and tranquillizing, restoring normal coordination between heart and kidney, unsmoothing the sperm and stopping bleeding.For the invasion of pericardium by heat, coma and delirium, breakdown of the normal physiological coordination between the heart and the kidney,
Insomnia seminal emission, blood-head is spitted blood.
Radix Angelicae Sinensis：Sweet, pungent, slight bitter, it is warm in nature.Return liver, the heart, the spleen channel.When the dry root for being classified as umbelliferae angelica.Have
Replenishing and activating blood, menstruction regulating and pain relieving, the effect for relaxing bowel.For blood deficiency chlorosis, dizziness palpitaition, irregular menstruation, closed dysmenorrhea, the cold of insufficiency type
Stomachache, dry constipation of intestines, arthralgia pain due to rheumatism, injury from falling down, ulcer sores.
The root of herbaceous peony：Bitter, acid, it is cold in nature.Return liver, the spleen channel.The root of herbaceous peony is the dry root of ranunculaceae plant Chinese herbaceous peony.Stop with soothing the liver
Bitterly, nourishing blood for regulating menstruation, effect of astringing YIN to stop sweating.For dizziness of having a headache, hypochondriac pain, stomachache, four limbs contraction bitterly, blood deficiency chlorosis, irregular menstruation,
Spontaneous perspiration, night sweat.
The root of kudzu vine：It is sweet, pungent, it is cool in nature.Returns spleen, stomach.The root of kudzu vine is the dry root of legume pueraria lobata.Brought down a fever with expelling pathogenic factors from muscles and skin,
Promote the production of body fluid, promoting eruption, effect of Shengyang Zhixie.It is thirsty for fever caused by exogenous pathogens headache, stiff nape and back, to quench one's thirst, measles without adequate eruption, hot dysentery is let out
Rush down；Hypertension neck pain.
Gorgon fruit：It is sweet, puckery, it is mild-natured.Returns spleen, kidney channel.Gorgon fruit is the dry mature kernal of nymphaeaceae plant Gorgon euryale.With kidney-nourishing
Controlling nocturnal emission with astringent drugs, tonifying spleen and stopping diarrhea, effect of tonifying spleen and stopping diarrhea.For emission, enuresis frequent micturition, insufficiency of the spleen chronic diarrhea, gonorrhoea, under band.
Sweet osmanthus：Taste is pungent, it is warm in nature.Sweet osmanthus is the flower of Oleaceae plants sweet-scented osmanthus.Flower contain aromatic substance, such as decanolactone, α-
Irisone, alpha, beta-lonone, trans- linalool oxide, cis- linalool oxide, linalool, aldehyde C-9 and β-phellandrene,
Nerol, Geraniol, dihydro-β-ionone.There is resolving sputum, the stasis of blood is dissipated.Ridiculed for phlegm and retained fluid and coughed, intestines wind bloody flux, hernia
Lump in the abdomen, toothache, halitosis.
Lamiophlomis rotata：Sweet, hardship, it is mild-natured.Herb is dried for labiate lamiophlomis rotata.With promoting blood circulation and hemostasis, wind-dispelling stops
Bitterly, effect of dry yellow water.For traumatic injury, traumatism and bleeding, arthralgia pain due to rheumatism, grasserie.
Cynanchum glaucescens：Taste is pungent, hardship, slightly warm in nature.Return lung is passed through.It is Asclepiadaceae plant rhizoma et radix cynanchi stauntoni or the dry rhizome of leaves of Daphne genkwa Cynanchum glaucescens
And root.With sending down abnormally ascending, dissolving phlegm, effect of cough-relieving.Stop up in fact for lung qi, coughing with a lot of sputum, fullness sensation in chest breathes heavily urgency.
Coix seed：It is sweet, light, it is cool in nature.Returns spleen, stomach, lung channel.It is the dry mature kernal of grass Job's tears.Have
Invigorating the spleen excreting dampness, remove numbness antidiarrheal, effect of clearing away heat and eliminating pus.For oedema, tinea pedis, difficult urination, arthritis with fixed pain caused by dampness contraction, splenasthenic diarrhea, lung
Bitterly, acute appendicitis, flat wart, invigorating the spleen excreting dampness, remove numbness antidiarrheal.
Milk thistle：Bitter, it is cool in nature.Return liver, gallbladder channel.It is the dry mature fruit of feverfew milk thistle.With heat-clearing solution
Poison, effect of 'Shugan Lidan '.For liver and gallbladder damp-heat, hypochondriac pain, jaundice.
Rhizoma cyperi：Taste is pungent, slight bitter, micro-sweet, it is mild-natured.Return liver, the spleen channel.It is the dry rhizome of sedge nutgrass flatsedge.With row
Gas solution is strongly fragrant, effect of menstruction regulating and pain relieving.For stagnation of QI due to depression of the liver, chest, the side of body, abdominal distention, indigestion, chest gastral cavity ruffian, cold hernia stomachache,
Swollen breasts, irregular menstruation, closed dysmenorrhea.
Asiatic plantain：It is sweet, it is cold in nature.Return liver, kidney, lung, small intestinl channel.For the drying of plantago plant Chinese herbaceous peony or ordinary building is complete
Grass.There is reducing fever and causing diuresis, eliminating the phlegm, cool blood, removing toxic substances.For oedema oliguria, puckery pain of heat gonorrhea, summer-heat and damp rush down dysentery, phlegm-heat cough,
Hematemesis and epistaxis, carbuncle sore tumefacting virus.
Emblic：It is sweet, sour, puckery, it is cool in nature.Attach to the lung and stomach meridians.It is the dry mature fruit of euphorbia plant emblic.Tool
There are clearing heat and cooling blood, food digesting stomach fortifying, the effect for cough-relieving of promoting the production of body fluid.For blood-head blood stasis, indigestion, abdominal distension, cough, laryngalgia, dry.
The root of Chinese clematis：It is taste is pungent, salty, it is warm in nature.Return bladder warp.It is the ranunculaceae plant root of Chinese clematis, Clematis hexapetala or northeast iron wire
Lotus dries root and rhizome.With dispelling wind and eliminating dampness, the effect removed obstruction in channels to relieve pain.For arthralgia pain due to rheumatism, extremity numbness, muscle arteries and veins contraction,
Joint stuffiness, bone chokes down larynx.
Beneficial effects of the present invention：The astaxanthin colla corii asini cake, with Astaxanthin In Haematococcus Pluvialis powder, donkey-hide gelatin, Semen sesami nigrum, walnut
The auxiliary materials such as benevolence, rock sugar and raw material based on yellow rice wine, additional jujube, longan, matrimony vine, raisins, rose powder, peppermint and it is various in
Herbal medicine is refined to be formed.Property during preparation according to all raw materials uses different processing modes, and the Chinese herbal medicine for using, root
Different treatment is used according to the pharmacology of all Chinese herbal medicines, such as adds lotus seeds after soaking Radix Angelicae Sinensis, the root of herbaceous peony, the root of kudzu vine, rhizoma cyperi and the root of Chinese clematis
The heart and Gorgon fruit are decocted jointly, rose powder will be added after peppermint, sweet osmanthus, lamiophlomis rotata and Asiatic plantain water extraction and concentrated, by Cynanchum glaucescens, Job's tears
Mix with other active ingredients after benevolence, milk thistle and emblic effective component extracting.The astaxanthin colla corii asini cake, was sought in the modern times
Support on the basis of learning, organically combined with the traditional Chinese medicine of Chinese tradition, take full advantage of nutritional ingredient contained by natural food and
Medium-height grass the effective elements of the medicine, in addition to it common are beneficial composition containing donkey-hide gelatin etc., also contains various Chinese herbal medicine effective ingredientses, Zhu Yuan
Material effect collaboration, outside the effects such as adjusting biological rhythm, antioxidant and anti-aging, enhancing immune function of human body, moreover it is possible to effectively adjust
Section sleep, realizes with health food to replace conventional medicament.
Specific embodiment
With reference to embodiment, the invention will be further described, but the invention is not limited in this, the system in embodiment
Preparation Method is customary preparation methods, no longer describes in detail.
Embodiment 1：The astaxanthin colla corii asini cake, the raw material for taking following portions by weight is prepared from (every part takes 30g)：Astaxanthin
8 parts of powder, 5 parts of donkey-hide gelatin, 3 parts of Semen sesami nigrum, 5 parts of walnut kernel, 3 parts of rock sugar, 13 parts of yellow rice wine, 4 parts of jujube, 5 parts of longan, 4 parts of matrimony vine, Portugal
Dry 4 parts of grape, 3 parts of rose powder, 4 parts of peppermint, 1.5 parts of lotus nut, 4 parts of Radix Angelicae Sinensis, 5 parts of the root of herbaceous peony, 5 parts of the root of kudzu vine, 4 parts of Gorgon fruit, sweet osmanthus 3
Part, 3 parts of lamiophlomis rotata, 4 parts of Cynanchum glaucescens, 3 parts of coix seed, 3 parts of milk thistle, 3 parts of rhizoma cyperi, 4 parts of Asiatic plantain, 2 parts of emblic, the root of Chinese clematis 3
Part.
The preparation method of above-mentioned astaxanthin colla corii asini cake, using following steps：
(1) Radix Angelicae Sinensis, the root of herbaceous peony, the root of kudzu vine, rhizoma cyperi and the root of Chinese clematis are cut into slices, is placed in marmite, add 6 times of Radix Angelicae Sinensis, the root of herbaceous peony, Pueraria lobotas
The pure water of root, rhizoma cyperi and root of Chinese clematis quality sum, after soaking 5 hours, adds lotus nut and Gorgon fruit, adds water to cook twice, every time
Filtered after decocting 50 minutes, merge filtrate twice；
(2) peppermint, sweet osmanthus, lamiophlomis rotata and Asiatic plantain are made meal, water extraction twice, after boiling 1 hour every time during water extraction
Filter, merge filtrate twice, to being well mixed after rose powder is added in merging filtrate, addition mass concentration is after standing 4 hours
73% alcohol, is sufficiently stirred for, filtering, removal precipitation, and the solution after removing precipitation is concentrated into relative density at 38 DEG C is
1.3 thick paste, then dry, pulverize into fine powder by thick paste below 60 DEG C, cross 70 mesh sieves, obtain powder；
(3) Cynanchum glaucescens, coix seed, milk thistle and emblic are crushed, crosses 50 mesh sieves, mixed, by the mixed material after mixing
It is placed in Chinese medicine extracting tank, to 9 times of water of mixed material quality are added in Chinese medicine extracting tank, extracts twice, 70 points is extracted every time
Filtered after clock, merge filtrate twice, the filtrate after merging is stood overnight, filtered, add step (1) gained filtrate, mixing is equal
It is even, the thick paste that relative density is 1.3 is concentrated at 40 DEG C, to being added in gained thick paste, the ethanol that mass concentration is 58% is molten
Liquid, to ethanol mass concentration be 33% when stop addition, stirring, will plus ethanol solution after thick paste stand overnight again after,
It is recovered under reduced pressure ethanol, adds step (2) gained powder, be well mixed, will obtains being placed in vacuum without alcohol condensed cream after mixing and do
In dry case, dry extract is dried at a temperature of 60 DEG C, it is standby；
(4) in one layer of preservative film of surfacing shakedown of stainless steel pallet, on preservative film surface, one layer of sesame oil of brush, standby；
(5) Semen sesami nigrum is eluriated twice, is dried, the Semen sesami nigrum after drying is placed in frying pan, slow fire is slowly heated not
Disconnected stirring, fries to Semen sesami nigrum slightly fragrance and is taken the dish out of the pot when being extruded and easily crushed with thumb and forefinger, is cooled to room temperature, obtains frying black
Sesame, it is standby；
(6) walnut kernel is placed in another frying pan, when the temperature that slow fire is slowly heated to walnut kernel is 40 DEG C, during slow fire turns
Fire continues to fry when walnut kernel is gently twisted with the fingers with hand underwear and easily comes off, and ceases fire, and takes the dish out of the pot, and is down to room temperature, obtains frying walnut kernel, standby；
(7) jujube and longan are enucleated, are placed in baking box, baked 8 minutes at 170 DEG C, taken out, traditional Chinese medicine powder is placed in after cooling
In broken machine, step (6) gained frying walnut kernel is added, crushed, cross 100 mesh sieves, obtain powder；
(8) donkey-hide gelatin is placed in powder beater and is crushed, cross 120 mesh sieves, the gelatin powder after sieving is placed in non-iron ware, plus
Enter by the rock sugar after crushing, place 3 days, add yellow rice wine, be put into Steam by water bath in pot, big fire is boiled and turns slow fire to after boiling and steam slowly,
Endure to hang flag (with wood shovel contain some lift when, donkey-hide gelatin slabbing hang over shovel on, slowly fallen down in a face flag shape, hang flag when
The concentration of paste is 1.47g/cm3) when add matrimony vine and raisins, stir, continue slow fire slowly steam 30 minutes after, add
Step (3) gained dry extract and step (7) gained powder, stir, and after continuing the slow steaming of slow fire 18 minutes, add astaxanthin powder
Frying Semen sesami nigrum obtained by (being Astaxanthin In Haematococcus Pluvialis powder, purchased from Xi'an Hao Yuan Bioisystech Co., Ltd) and step (5),
Stir 9 minutes clockwise, Guan Huo is taken the dish out of the pot, and the product after taking the dish out of the pot is poured in step (4) ready stainless steel pallet, flatten,
Cool to room temperature, freezed 20 hours at a temperature of -6 DEG C, stripping and slicing is carried out with every piece of quality 30g, pack, obtain final product astaxanthin Ah
Glue cake.
Usage and dosage：It is edible daily to eat one piece every time twice, eaten within 1 hour with after supper before meals respectively at early, take
When more drink warm water.
Embodiment 2：The astaxanthin colla corii asini cake, its active component is made up (every part takes 15g) of the raw material of following weight：Shrimp is blue or green
12 parts of plain powder, 8 parts of donkey-hide gelatin, 6 parts of Semen sesami nigrum, 9 parts of walnut kernel, 5 parts of rock sugar, 16 parts of yellow rice wine, 6 parts of jujube, 7 parts of longan, matrimony vine 7
Part, 6 parts of raisins, 5 parts of rose powder, 7 parts of peppermint, 2.2 parts of lotus nut, 7 parts of Radix Angelicae Sinensis, 7 parts of the root of herbaceous peony, 8 parts of the root of kudzu vine, 6 parts of Gorgon fruit, osmanthus
Spend 5 parts, 4 parts of lamiophlomis rotata, 6 parts of Cynanchum glaucescens, 5 parts of coix seed, 6 parts of milk thistle, 5 parts of rhizoma cyperi, 7 parts of Asiatic plantain, 3 parts of emblic, Wheeling
It is celestial 7 parts.
Preparation method is with usage and dosage with embodiment 1.
Embodiment 3：The astaxanthin colla corii asini cake, its active component is made up (every part takes 25g) of the raw material of following weight：Shrimp is blue or green
9 parts of plain powder, 6 parts of donkey-hide gelatin, 4 parts of Semen sesami nigrum, 6 parts of walnut kernel, 3.5 parts of rock sugar, 14 parts of yellow rice wine, 4.5 parts of jujube, 5.5 parts of longan, Chinese holly
5 parts of Qi, 4.5 parts of raisins, 3.5 parts of rose powder, 5 parts of peppermint, 1.8 parts of lotus nut, 5 parts of Radix Angelicae Sinensis, 5.5 parts of the root of herbaceous peony, 6 parts of the root of kudzu vine,
4.5 parts of Gorgon fruit, 3.5 parts of sweet osmanthus, 3.3 parts of lamiophlomis rotata, 4.5 parts of Cynanchum glaucescens, 3.5 parts of coix seed, 4 parts of milk thistle, 3.5 parts of rhizoma cyperi, car
First careless 5 parts, 2.3 parts of emblic, 4 parts of the root of Chinese clematis.
Preparation method is with usage and dosage with embodiment 1.
Embodiment 4：The astaxanthin colla corii asini cake, its active component is made up (every part takes 20g) of the raw material of following weight：Shrimp is blue or green
11 parts of plain powder, 7 parts of donkey-hide gelatin, 5 parts of Semen sesami nigrum, 8 parts of walnut kernel, 4.5 parts of rock sugar, 15 parts of yellow rice wine, 5.5 parts of jujube, 6.5 parts of longan,
6 parts of matrimony vine, 5.5 parts of raisins, 4.5 parts of rose powder, 6 parts of peppermint, 1.9 parts of lotus nut, 6 parts of Radix Angelicae Sinensis, 6.5 parts of the root of herbaceous peony, the root of kudzu vine 7
Part, 5.5 parts of Gorgon fruit, 4.5 parts of sweet osmanthus, 3.7 parts of lamiophlomis rotata, 5.5 parts of Cynanchum glaucescens, 4.5 parts of coix seed, 5 parts of milk thistle, 4.5 parts of rhizoma cyperi,
6 parts of Asiatic plantain, 2.7 parts of emblic, 6 parts of the root of Chinese clematis.
Preparation method is with usage and dosage with embodiment 1.
Embodiment 5：The astaxanthin colla corii asini cake, its active component is made up (every part takes 35g) of the raw material of following weight：Shrimp is blue or green
10 parts of plain powder, 7 parts of donkey-hide gelatin, 5 parts of Semen sesami nigrum, 7 parts of walnut kernel, 4 parts of rock sugar, 15 parts of yellow rice wine, 5 parts of jujube, 6 parts of longan, matrimony vine 6
Part, 5 parts of raisins, 4 parts of rose powder, 6 parts of peppermint, 1.9 parts of lotus nut, 6 parts of Radix Angelicae Sinensis, 6 parts of the root of herbaceous peony, 7 parts of the root of kudzu vine, 5 parts of Gorgon fruit, osmanthus
Spend 4 parts, 3.5 parts of lamiophlomis rotata, 5 parts of Cynanchum glaucescens, 4 parts of coix seed, 5 parts of milk thistle, 4 parts of rhizoma cyperi, 6 parts of Asiatic plantain, 2.5 parts of emblic,
5 parts of the root of Chinese clematis.
Preparation method is with usage and dosage with embodiment 1.
Test example：For present invention gained astaxanthin colla corii asini cake, we have done the effect experiment for improving the health care of sleep quality respectively
With the effect experiment of strengthen immunity.
Experiment 1：Improve the health care of sleep the effect experiment of quality
In order to verify the curative effect for improving the health care of sleep of present invention gained astaxanthin colla corii asini cake, inventor is in May, 2011-2011
November in year has done the clinical trial for improving the health care of sleep by experimental subjects of small white mouse.
(1) experiment material
Random to take present invention gained astaxanthin colla corii asini cake (embodiment 1-5), yellow Jackets, barbital sodium are by middle traditional Chinese medical science
Medicine (group) Solution on Chemical Reagents in Shanghai company provides.
The Kunming small white mouse 210 of health is screened, 18~22g of body weight is provided by Jinan institute of Chinese materia medica.In constant temperature, peace
Under quiet, cleaning ambient, sub-cage rearing.(control group is condition control group and blank to be randomly divided into experimental group and control group
Group), wherein, experimental group 150, control group 60 (condition control group and blank control group are respectively 30), two groups body weight,
The aspects such as health status there are no significant difference (P ＞ 0.05), with comparativity.
(2) specific experiment method
Experimental group：Random to take present invention gained astaxanthin colla corii asini cake (embodiment 1-5), chopping, plus distilled water is boiled into liquid
Shape, feed daily twice, respectively at it is early before meals with supper after 1 hour, continuously feed 30 days.Control group：Condition control group, daily
Feed other health products for improving the health care of sleep (purchased from Shandong Sheng Hai health products Co., Ltd) of equivalent, equally respectively at it is early before meals and
Feed twice within 1 hour after supper, continuously feed 30 days；Blank control group, feeds the distilled water of equivalent, equally respectively at morning daily
Fed twice within 1 hour with after supper before meals, continuously fed 30 days.
1st, direct sleep laboratory：Observe whether mouse sleep phenomenon occurs after last dose, sleep is disappeared with righting reflex
Lose is index (righting reflex can immediately right body position i.e. when mouse is placed in dorsal position).Such as more than 60s can not the person of righting, i.e.,
Righting reflex loss is thought, into sleep.Righting reflex recovers to be animal awakening, and righting reflex loss to righting reflex is recovered
This period be the length of one's sleep, compare control group and experimental group sleep number of animals and the length of one's sleep.
As a result, eat the experimental group of present invention gained astaxanthin colla corii asini cake and eat other health products for improving the health care of sleep quality
Condition control group and the no animal of blank control group there are righting reflex loss, i.e. all animals and do not enter into sleep
State, it can be seen that the astaxanthin colla corii asini cake and other improve the health care of sleep the health products of quality all without the work for directly improving mice sleep
With that is, without obvious directly syngignoscism.
2nd, indirect sleep laboratory
Criterion：According to《Health food is checked and assessment technique specification》In improve the health care of sleep functional check method judgement
Standard, if extension yellow Jackets length of one's sleep experiment, yellow Jackets sub-threshold dose hypnosis experiment, barbital sodium sleep latency
Phase tests 2 positives in 3 experiments, and without substantially direct syngignoscism, can determine that the given the test agent has and improve the health care of sleep function
Effect.
2.1 extension yellow Jackets length of one's sleep experiments：After last dose 20~25 minutes, to experimental group and control
The animal of group carries out intraperitoneal injection yellow Jackets 40mg/kg.Indicated to fall asleep with righting reflex loss, observation present invention gained
Can the health products that astaxanthin colla corii asini cake improves the health care of sleep quality with other extend the yellow Jackets length of one's sleep.Comparative experiments group with
The length of one's sleep of control group.
2.2 yellow Jackets sub-threshold dose hypnosis tests：After last dose 20~25 minutes, to experimental group and control
The animal of group carries out intraperitoneal injection yellow Jackets 30mg/kg.Each group sleep number of animals in 30 minutes is observed and records (to right anti-
Penetrate disappearance and reach more than 1 minute person).
2.3 barbital sodium Sleep Latency Tests：After last dose 20~25 minutes, to experimental group and control group
Animal carries out intraperitoneal injection barbital sodium 300mg/kg.Indicated to fall asleep with righting reflex loss, observation present invention gained shrimp is blue or green
Can the health products that plain colla corii asini cake improves the health care of sleep quality with other shorten barbital sodium Sleep latency.
Using the statistical softwares of SPSS 13.0, compare between different groups of the length of one's sleep and use variance analysis, with many between-group variances
LSD-t inspections take statistics treatment between analysis and group, and sleep incidence compares and uses χ2Inspection.When extension yellow Jackets are slept
Between experiment, yellow Jackets sub-threshold dose hypnosis experiment, the concrete condition of barbital sodium Sleep latency experiment be shown in Table 1 respectively,
Shown in table 2, table 3：
Table 1 extends yellow Jackets length of one's sleep experimental result (x ± s)
As seen from Table 1, the experimental group for eating present invention gained astaxanthin colla corii asini cake significantly extends mouse yellow Jackets
The length of one's sleep, with the same period eat other health products for improving the health care of sleep condition control group and blank control group compared with,
With significant difference (P ＜ 0.01), show that present invention gained astaxanthin colla corii asini cake extends the reality of the yellow Jackets length of one's sleep
It is positive, and more more significantly than the curative effect of the existing health products for improving the health care of sleep to test result.
Influence of the table 2 to yellow Jackets sub-threshold dose syngignoscism
As seen from Table 2, present invention gained astaxanthin colla corii asini cake and the condition for eating other health products for improving the health care of sleep are eaten
Control group and blank control group are compared, and the sleep rate of animal is dramatically increased (P ＜ 0.01).Show present invention gained astaxanthin Ah
The yellow Jackets subliminal hypnosis experimental result of glue cake is the positive, that is, illustrate the penta bar ratio of the astaxanthin colla corii asini cake and sub-threshold dose
Appropriate sodium has collaboration syngignoscism；And have the effect of the health products for improving the health care of sleep more significantly than existing other.
Experimental result (x ± s) of the table 3 to barbital sodium Sleep latency
As seen from Table 3, the experimental group for eating present invention gained astaxanthin colla corii asini cake significantly reduces mouse barbital sodium
Sleep latency, with the same period eat other health products for improving the health care of sleep condition control group and blank control group compared with,
Significant difference (P ＜ 0.01) is respectively provided with, shows that present invention gained astaxanthin colla corii asini cake shortens barbital sodium Sleep latency
Experimental result is positive and more more significantly than the curative effect of the existing health products for improving the health care of sleep.
In summary it can be seen, although present invention gained astaxanthin colla corii asini cake extends penta bar without substantially direct syngignoscism
The positive is than the experiment of the appropriate sodium length of one's sleep, yellow Jackets sub-threshold dose hypnosis experiment, the experiment of barbital sodium Sleep latency,
So according to《Health food is checked and assessment technique specification》In improve the health care of sleep functional check method criterion, can obtain
Astaxanthin colla corii asini cake of the present invention has the effect for improving the health care of sleep function.Meanwhile, there is the guarantor for improving the health care of sleep effect by with other
The control of strong product, it can be seen that the effect for improving the health care of sleep of astaxanthin colla corii asini cake of the present invention is more significantly, should be widely promoted.
Test the effect experiment of 2 strengthen immunities
In order to verify the present invention gained astaxanthin colla corii asini cake strengthen immunity effect, inventor in April, 2011-
In October, 2012 has done contrast test, and by determining the phagocytic function of macrophage, (macrophage is that a kind of being located at is organized respectively
Interior white blood cell, is phagocyte, non-specific defence is participated in vertebrate and specificity is defended.Major function be with
The form of fixed cell or free cell carries out phagocytosis to cell debris and pathogen, and activates lymph corpuscle or other are immune
Cell, makes it react pathogen.Macrophage is the important right of the phagocytosis of research cell, cellular immunity and molecular immunology
As) and PBLC ANAE positive rates carry out immunity evaluation.
2.1 test materials
The experimental rabbit 210 of health is screened, the body size of rabbit, age and feeding and management are close or identical, through variance
Analysis difference is not notable (p ＞ 0.05).
2.2 test methods
The experimental rabbit of 210 health screened is randomly divided into two groups of experimental group and control group, wherein experimental group has 150
Only, 5 groups are randomly divided into, each group there are 30, and control group there are 60, is randomly divided into condition control group and blank
Group, each group has 30.The edible present invention gained astaxanthin colla corii asini cake of the experimental rabbit of experimental group, condition control group eats equivalent
Other there are the health products (such as albumen powder, purchased from Shandong Sheng Hai health products Co., Ltd) of enhance immunity, blank control group
The pure water of edible equivalent.Each group is immunized by the immune programme for children of regulation, experimental group and the equal free choice feeding of control group, raises pipe
Manage bar part is identical.Each group experimental rabbit feeds off-test when observing 5 months.
2.21 Peritoneal Macrophage Phagocytosis are determined
Two groups carry out the albumen of intraperitoneal injection 5% to experimental rabbit when 1 month, 2 months, 3 months, 4 months, 5 months
Peptone, the 1mL/ intraperitoneal injection of inactivated vaccine after 24h to dilute, extracts peritoneal fluid after 0.5h, clean sterilizing is coated in rapidly
On slide, after 1.0h is incubated in wet box, gently rinsed with physiological saline, remove not adherent cell, dried, methyl alcohol is fixed,
300 macrophages are counted after acid-fast stain under oil mirror, phagocytic activity is represented with following two indices：Phagocytic percentage：(gulp down
Bite the peritoneal macrophage number of tubercle bacillus/by the peritoneal macrophage number of radix) × 100%.Phagocytic index：That is each macrophage
The average (by phagocytosis tubercle bacillus number/by numeration peritoneal macrophage number) of the tubercle bacillus of cell phagocytosis.
Using Excel 2003 and the software kits of SPASS 13.0, counted with the univariate analysis of variance and Chi-square Test,
Data represent that P ＜ 0.05 are significant difference with average and standard deviation (X ± SD), and P ＜ 0.01 are that difference is extremely notable, specific feelings
Condition is shown in Table 4
Influence of the table 4 to experimental rabbit Peritoneal Macrophage Phagocytosis
The curative effect for being statistically analyzed experimental group and control group has effective sex differernce (p ＜ 0.001), illustrates the treatment of experimental group
Effect effect is better than control group.And as can be seen from Table 4, the experimental group of present invention gained astaxanthin colla corii asini cake is eaten to experimental rabbit
The Peritoneal Macrophage Phagocytosis effect of increasing significantly, and the control group of the health products of other enhance immunities is eaten to reality
Rabbit Peritoneal Macrophage Phagocytosis are tested far away from experimental group.Wherein, the 5th of the gained astaxanthin colla corii asini cake of embodiment 5 is eaten
Month when, the phagocytic percentage and phagocytic index of experimental group be respectively 25.83 ± 2.12 and 0.91 ± 0.05, and condition control group
Phagocytic percentage and phagocytic index are respectively 18.31 ± 2.04 and 0.69 ± 0.05, the phagocytic percentage of blank control group and gulp down
Bite index and be respectively 15.78 ± 1.88 and 0.49 ± 0.04.
From the point of view of whole process of the test, eat present invention gained astaxanthin colla corii asini cake and experimental rabbit peritoneal macrophage is swallowed
Function much than blank control group and eat other enhance immunities health products condition control group it is high.This shows, this
Invention gained astaxanthin colla corii asini cake can preferably strengthen the nonspecific mental retardation of body, so as to further significantly improve body
Resistance.
2.22 peripheral bloods acidity ɑ-naphthyl acetate esterase (ANAE) positive rate
(1) principle：The ripe lymphocyte endochylema of normal development is contained within the acid ɑ-naphthyl acetate esterase of certain content, its
The number of content can reflect the function of lymphocyte.
(2) preparation of reagent：
2.5% glutaraldehyde fixer：2.5% glutaraldehyde is added in the phosphate buffer of 9m1 0.1mol/L pH value 7.4
Solution 1ml, it is standby that 4 DEG C of Refrigerator stores are put in mixing.
Peacock green dyeing liquor：Peacock green 1g is taken, the distilled water 100ml of pre-temperature to 37 DEG C is added, rearmounted Refrigerator store is dissolved
It is standby.
Reaction solution：Solution A：KH2P049.12g, plus distilled water is to 1000ml；Second liquid：NaHP049.49g, plus distilled water is extremely
1000ml) second liquid 87ml is added to obtain final product 0.065mol/L, pH7.5 phosphate buffer in 13ml solution As.Paramagenta 4g is added
In 100m1 2mol/L hydrochloric acid, put and dissolve it in 37 DEG C of water-baths, after being filtered with filter paper, obtain paramagenta solution；Take natrium nitrosum
0.2g, is dissolved in 5ml distilled water, obtains sodium nitrite solution；The sodium nitrite solution 3ml of new configuration is taken, paramagenta is slowly added into
Solution 3ml, is shaken in drop, and now irritant gas is produced, and is sufficiently mixed, and obtains six azo paramagenta liquid.By ɑ-naphthylacetate
Enzyme 2g is dissolved in 100ml glycol monoethyl ethers, obtains ɑ-naphthylacetate enzyme solutions.Finally, 0.065mol/L, pH7.5 phosphoric acid is taken to delay
Fliud flushing 89ml, is poured into staining jar, is slowly added into six azo paramagenta liquid 6ml, after being sufficiently mixed, then slowly instills ɑ-acetic acid naphthalene
Esterase solution 2.5ml, fully mixes, and solution adjusts pH to 5.8~6.4 in uniform muddy, and this reaction solution should configured before use.
(3) experiment determines operation：
Anticoagulation centrifugal treating：1.5~2ml of lymphocytes separating solution is added toward centrifuge tube, anticoagulation is drawn with suction pipe
About 1ml, blows slowly along tube wall and is overlapped on layering liquid, 2000~3000 revs/min of centrifugation 20min.Ttom of pipe be granulocyte and red blood cell,
Upper plasma separately takes small centrifuge tube and adds 3~5ml Hank's liquid (being a kind of balanced salt solution), is drawn with glue head dropper and is centrifuged
Buffy coat (forming milky cellular layer between blood plasma and layering liquid after centrifugation) afterwards, mixing, 1000~1500r/min from
Heart 10min, abandons supernatant, gently shakes, and makes cell resuspended, then adds Hank ' s liquid centrifuge washings, totally three times, abandons supernatant.
Film-making：The lymphocyte of gained after a small amount of above-mentioned centrifugation is dipped with glass bar, is applied on slide.Smear is dried
Plus 1 afterwards and drip 2.5% glutaraldehyde, 10min is fixed at 4 DEG C, flowing water is fully rinsed, and slide is placed in 37 DEG C of reaction solution, 37 DEG C
L~1.5h is incubated, is rinsed with flowing water after taking-up, drying.By the drying of above-mentioned slide, 1% peacock green is added dropwise and redyes 30s, flowing water punching
Wash, dry up.
Observed under 10 × 40 power microscopes again, counted.Every part of sample at least counts 200 lymphocytes, and T, B are write down respectively
Lymphocyte number, calculates ANAE lymphocytes positive percentage (%).
Using Excel2003 and the software kits of SPASS 13.0, counted with the univariate analysis of variance and Chi-square Test, number
Average and standard deviation (X ± SD) expression, P according to this<0.05 is significant difference, P<0.01 is that difference is extremely notable, and concrete condition is shown in
Table 5
Influence (X ± SD) of the table 5 to experimental rabbit PBLC ANAE positive rates (%)
The curative effect for being statistically analyzed experimental group and control group has effective sex differernce (p<0.001) treatment of experimental group, is illustrated
Effect effect is better than control group.And as can be seen from Table 5, the experimental group of present invention gained astaxanthin colla corii asini cake is eaten to experimental rabbit
The PBLC ANAE positive rates effect of increasing significantly, and blank control group and eat other tools it is immune
The condition control group of health products is to the PBLC ANAE positive rates of experimental rabbit far away from experimental group.Wherein, eat real
When applying 5 gained astaxanthin colla corii asini cake of example 5th month, experimental group is to the PBLC ANAE positive rates of experimental rabbit
37.08 ± 1.76, and blank control group and eat other immune health products of tool condition control groups be only 31.73 ±
1.96 and 33.56 ± 2.11.
From the point of view of whole process of the test, PBLC of the present invention gained astaxanthin colla corii asini cake to experimental rabbit is eaten
The castering action of ANAE positive rates much than blank control group and eats the high of other health products with enhance immunity.This table
Bright, astaxanthin colla corii asini cake of the present invention can preferably strengthen the cellular immunity function of body, so as to further significantly improve body
Resistance.
Finally it should be noted that embodiment is the optimal specific embodiment of the present invention, this is not limited to
Invention, although being described in detail to the present invention with reference to the foregoing embodiments, for a person skilled in the art, its according to
The technical scheme described in foregoing embodiments can so be modified, or which part technical characteristic is equally replaced
Change.All any modification, equivalent substitution and improvements within the spirit and principles in the present invention, made etc., should be included in the present invention
Protection domain within.
Claims (6)
1. a kind of astaxanthin colla corii asini cake, it is characterized in that：Its active component is prepared from the following raw materials in parts by weight：Astaxanthin powder 8
~12 parts, 5~8 parts of donkey-hide gelatin, 3~6 parts of Semen sesami nigrum, 5~9 parts of walnut kernel, 3~5 parts of rock sugar, 13~16 parts of yellow rice wine, jujube 4~6
Part, 5~7 parts of longan, 4~7 parts of matrimony vine, 4~6 parts of raisins, 3~5 parts of rose powder, 4~7 parts of peppermint, lotus nut 1.5~2.2
Part, 4~7 parts of Radix Angelicae Sinensis, 5~7 parts of the root of herbaceous peony, 5~8 parts of the root of kudzu vine, 4~6 parts of Gorgon fruit, 3~5 parts of sweet osmanthus, 3~4 parts of lamiophlomis rotata, Cynanchum glaucescens 4
~6 parts, 3~5 parts of coix seed, 3~6 parts of milk thistle, 3~5 parts of rhizoma cyperi, 4~7 parts of Asiatic plantain, 2~3 parts of emblic, the root of Chinese clematis 3
~7 parts.
2. a kind of astaxanthin colla corii asini cake according to claim 1, it is characterized in that：Its active component is by following parts by weight
Raw material is made：10 parts of astaxanthin powder, 7 parts of donkey-hide gelatin, 5 parts of Semen sesami nigrum, 7 parts of walnut kernel, 4 parts of rock sugar, 15 parts of yellow rice wine, 5 parts of jujube, osmanthus
6 parts of circle, 6 parts of matrimony vine, 5 parts of raisins, 4 parts of rose powder, 6 parts of peppermint, 1.9 parts of lotus nut, 6 parts of Radix Angelicae Sinensis, 6 parts of the root of herbaceous peony, the root of kudzu vine 7
Part, 5 parts of Gorgon fruit, 4 parts of sweet osmanthus, 3.5 parts of lamiophlomis rotata, 5 parts of Cynanchum glaucescens, 4 parts of coix seed, 5 parts of milk thistle, 4 parts of rhizoma cyperi, 6 parts of Asiatic plantain,
2.5 parts of emblic, 5 parts of the root of Chinese clematis.
3. according to a kind of any described astaxanthin colla corii asini cakes of claim 1-2, it is characterized in that：Described astaxanthin powder is given birth to for rain
Haematococcus astaxanthin powder.
4. according to a kind of preparation method of any described astaxanthin colla corii asini cakes of claim 1-2, it is characterized in that：Including following step
Suddenly：
(1) Radix Angelicae Sinensis, the root of herbaceous peony, the root of kudzu vine, rhizoma cyperi and the root of Chinese clematis are cut into slices, are placed in marmite, add 5~7 times of Radix Angelicae Sinensis, the root of herbaceous peony, the root of kudzu vine,
Rhizoma cyperi and the pure water of root of Chinese clematis quality sum, after soaking 4~6 hours, add lotus nut and Gorgon fruit, add water to cook twice, every time
Filtered after decocting 40~60 minutes, merge filtrate twice；
(2) peppermint, sweet osmanthus, lamiophlomis rotata and Asiatic plantain are made meal, water extraction twice, is filtered after being boiled 1 hour every time during water extraction,
Merge filtrate twice, to being well mixed after rose powder is added in merging filtrate, addition mass concentration is after standing 3~4 hours
70%~75% alcohol, is sufficiently stirred for, filtering, removal precipitation, the solution concentration after removing precipitation at 35 DEG C~40 DEG C
To the thick paste that relative density is 1.2~1.4, thick paste then be dry, pulverize into fine powder below 60 DEG C, crosses 60~80 mesh sieves,
Obtain powder；
(3) Cynanchum glaucescens, coix seed, milk thistle and emblic are crushed, crosses 40~60 mesh sieves, mixed, by the mixed material after mixing
It is placed in Chinese medicine extracting tank, to 8~10 times of water of mixed material quality are added in Chinese medicine extracting tank, extracts twice, extracts every time
Filtered after 60~80 minutes, merge filtrate twice, the filtrate after merging is stood overnight, filtered, add step (1) gained filter
Liquid, is well mixed, and the thick paste that relative density is 1.25~1.35 is concentrated at 38 DEG C~41 DEG C, to adding matter in gained thick paste
Amount concentration be 55%~60% ethanol solution, to ethanol mass concentration be 29%~36% when stop addition, stirring, will plus
After thick paste after ethanol solution stands overnight again, ethanol is recovered under reduced pressure, adds step (2) gained powder, be well mixed, will be mixed
What is obtained after even is placed in vacuum drying chamber without alcohol condensed cream, and dry extract is dried at a temperature of 55 DEG C~65 DEG C, standby；
(4) in one layer of preservative film of surfacing shakedown of stainless steel pallet, on preservative film surface, one layer of sesame oil of brush, standby；
(5) Semen sesami nigrum is eluriated twice, is dried, the Semen sesami nigrum after drying is placed in frying pan, slow fire is slowly heated and constantly stirs
Mix, fry to Semen sesami nigrum slightly fragrance and taken the dish out of the pot when being extruded and easily crushed with thumb and forefinger, be cooled to room temperature, obtain the black sesame of frying
Fiber crops, it is standby；
(6) walnut kernel is placed in another frying pan, when the temperature that slow fire is slowly heated to walnut kernel is 38 DEG C~42 DEG C, slow fire turns
Moderate heat continues to fry when walnut kernel is gently twisted with the fingers with hand underwear and easily comes off, and ceases fire, and takes the dish out of the pot, and is down to room temperature, obtains frying walnut kernel, standby
With；
(7) jujube and longan are enucleated, are placed in baking box, baked 5~10 minutes at 160 DEG C~180 DEG C, taken out, cooled rearmounted
In medicinal herb grinder, step (6) gained frying walnut kernel is added, crushed, cross 80~120 mesh sieves, obtain powder；
(8) donkey-hide gelatin is placed in powder beater and is crushed, cross 100~140 mesh sieves, the gelatin powder after sieving is placed in non-iron ware,
Add by the rock sugar after crushing, place 2~3 days, add yellow rice wine, be put into Steam by water bath in pot, big fire is boiled and turns slow fire to after boiling
It is slow to steam, endure and add matrimony vine and raisins when flag is hung, stir, after continuation slow fire steams 25~35 minutes slowly, add step (3)
Gained dry extract and step (7) gained powder, stir, continue slow fire slowly steam 15~20 minutes after, add astaxanthin powder and
Frying Semen sesami nigrum obtained by step (5), is stirred 8~10 minutes clockwise, and Guan Huo is taken the dish out of the pot, and the product after taking the dish out of the pot is poured on into step
(4) in ready stainless steel pallet, flatten, cool to room temperature, freezed 15~25 hours at a temperature of -4 DEG C~-8 DEG C, with
Every piece of quality 28g~30g carries out stripping and slicing, packaging, obtains final product the astaxanthin colla corii asini cake.
5. the preparation method of a kind of astaxanthin colla corii asini cake according to claim 4, it is characterized in that：Hung described in step (8)
Flag refers to that donkey-hide gelatin slabbing is hung on shovel, is slowly fallen down in a face flag shape, paste when hanging flag when containing some with wood shovel to lift
The concentration of thing is 1.46g/cm3~1.49g/cm3。
6. the preparation method of a kind of astaxanthin colla corii asini cake according to claim 4, it is characterized in that：Shrimp in step (8) is blue or green
Plain powder is Astaxanthin In Haematococcus Pluvialis powder.
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Cited By (3)
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|---|---|---|---|---|
| CN107232514A (en) * | 2017-06-30 | 2017-10-10 | 江西景德中药股份有限公司 | A kind of donkey-hide gelatin vitality firming ointment and preparation method thereof |
| CN109527551A (en) * | 2018-12-21 | 2019-03-29 | 吉林省亿生食品有限公司 | A kind of colla corii asini cake and preparation method thereof |
| CN110742268A (en) * | 2018-12-11 | 2020-02-04 | 山东建筑大学 | Preparation method of natto donkey-hide gelatin cake and natto donkey-hide gelatin cake |
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| CN105726574A (en) * | 2016-04-02 | 2016-07-06 | 林�源 | Preparation and application of eretmochelys imbricate linnaeus colloid |
| CN106072509A (en) * | 2016-05-18 | 2016-11-09 | 任建军 | A kind of colla corii asini cake and preparation method thereof |
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| CN102895410A (en) * | 2012-09-10 | 2013-01-30 | 青岛广昭国际贸易有限公司 | Health-strengthening donkey-hide gelatin jelly for females |
| CN102987395A (en) * | 2012-12-10 | 2013-03-27 | 大连创达技术交易市场有限公司 | Health-maintaining vigor-curing paste |
| CN103005245A (en) * | 2012-12-27 | 2013-04-03 | 苗娥 | Longan paste and preparation method thereof |
| CN103393100A (en) * | 2013-06-28 | 2013-11-20 | 安徽燕之坊食品有限公司 | Paste product |
| CN105726574A (en) * | 2016-04-02 | 2016-07-06 | 林�源 | Preparation and application of eretmochelys imbricate linnaeus colloid |
| CN106072509A (en) * | 2016-05-18 | 2016-11-09 | 任建军 | A kind of colla corii asini cake and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN107232514A (en) * | 2017-06-30 | 2017-10-10 | 江西景德中药股份有限公司 | A kind of donkey-hide gelatin vitality firming ointment and preparation method thereof |
| CN110742268A (en) * | 2018-12-11 | 2020-02-04 | 山东建筑大学 | Preparation method of natto donkey-hide gelatin cake and natto donkey-hide gelatin cake |
| CN109527551A (en) * | 2018-12-21 | 2019-03-29 | 吉林省亿生食品有限公司 | A kind of colla corii asini cake and preparation method thereof |
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