CN110140969A - A kind of preparation process thereof containing powder and the full nutrient formulation powder of tumour using its preparation - Google Patents
A kind of preparation process thereof containing powder and the full nutrient formulation powder of tumour using its preparation Download PDFInfo
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- CN110140969A CN110140969A CN201910558344.7A CN201910558344A CN110140969A CN 110140969 A CN110140969 A CN 110140969A CN 201910558344 A CN201910558344 A CN 201910558344A CN 110140969 A CN110140969 A CN 110140969A
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- 238000009472 formulation Methods 0.000 title description 8
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- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 claims description 10
- 230000035764 nutrition Effects 0.000 claims description 10
- 239000011719 vitamin A Substances 0.000 claims description 10
- 235000019155 vitamin A Nutrition 0.000 claims description 10
- 229940045997 vitamin a Drugs 0.000 claims description 10
- 239000000463 material Substances 0.000 claims description 6
- KDYFGRWQOYBRFD-UHFFFAOYSA-N succinic acid Chemical compound OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 claims description 6
- 238000012545 processing Methods 0.000 claims description 5
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 4
- 239000011734 sodium Substances 0.000 claims description 4
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- 235000015424 sodium Nutrition 0.000 claims description 4
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- 239000003963 antioxidant agent Substances 0.000 claims description 3
- 239000005018 casein Substances 0.000 claims description 3
- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 claims description 3
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- 229920000159 gelatin Polymers 0.000 claims description 2
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- 239000011715 vitamin B12 Substances 0.000 description 12
- FDJOLVPMNUYSCM-WZHZPDAFSA-L cobalt(3+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(1r,2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2 Chemical compound [Co+3].N#[C-].N([C@@H]([C@]1(C)[N-]\C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C(\C)/C1=N/C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C\C1=N\C([C@H](C1(C)C)CCC(N)=O)=C/1C)[C@@H]2CC(N)=O)=C\1[C@]2(C)CCC(=O)NC[C@@H](C)OP([O-])(=O)O[C@H]1[C@@H](O)[C@@H](N2C3=CC(C)=C(C)C=C3N=C2)O[C@@H]1CO FDJOLVPMNUYSCM-WZHZPDAFSA-L 0.000 description 7
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- ODKSFYDXXFIFQN-BYPYZUCNSA-N L-arginine Chemical compound OC(=O)[C@@H](N)CCCN=C(N)N ODKSFYDXXFIFQN-BYPYZUCNSA-N 0.000 description 6
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- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 description 2
- 238000012938 design process Methods 0.000 description 2
- BVTBRVFYZUCAKH-UHFFFAOYSA-L disodium selenite Chemical compound [Na+].[Na+].[O-][Se]([O-])=O BVTBRVFYZUCAKH-UHFFFAOYSA-L 0.000 description 2
- 239000003995 emulsifying agent Substances 0.000 description 2
- 235000010413 sodium alginate Nutrition 0.000 description 2
- 229940005550 sodium alginate Drugs 0.000 description 2
- 239000000661 sodium alginate Substances 0.000 description 2
- 229960001471 sodium selenite Drugs 0.000 description 2
- 239000011781 sodium selenite Substances 0.000 description 2
- 235000015921 sodium selenite Nutrition 0.000 description 2
- 238000001694 spray drying Methods 0.000 description 2
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 1
- 239000005864 Sulphur Substances 0.000 description 1
- 229930003270 Vitamin B Natural products 0.000 description 1
- 230000003321 amplification Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- ARUVKPQLZAKDPS-UHFFFAOYSA-L copper(II) sulfate Chemical compound [Cu+2].[O-][S+2]([O-])([O-])[O-] ARUVKPQLZAKDPS-UHFFFAOYSA-L 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 238000010348 incorporation Methods 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 239000011785 micronutrient Substances 0.000 description 1
- 235000013369 micronutrients Nutrition 0.000 description 1
- 239000011812 mixed powder Substances 0.000 description 1
- 238000003199 nucleic acid amplification method Methods 0.000 description 1
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- 235000010378 sodium ascorbate Nutrition 0.000 description 1
- PPASLZSBLFJQEF-RKJRWTFHSA-M sodium ascorbate Substances [Na+].OC[C@@H](O)[C@H]1OC(=O)C(O)=C1[O-] PPASLZSBLFJQEF-RKJRWTFHSA-M 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
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- 235000019156 vitamin B Nutrition 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/15—Vitamins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/15—Vitamins
- A23L33/155—Vitamins A or D
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/16—Inorganic salts, minerals or trace elements
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
- A23P10/00—Shaping or working of foodstuffs characterised by the products
- A23P10/30—Encapsulation of particles, e.g. foodstuff additives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Mycology (AREA)
- Health & Medical Sciences (AREA)
- Nutrition Science (AREA)
- Inorganic Chemistry (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Abstract
The object of the present invention is to provide a kind of methods of the mixture homogeneity of the less vitamin and mineral of powder additive amount in raising preparation, by being used further to formula powder production after the remanufacturing respectively of liposoluble vitamin, water soluble vitamin and trace mineral, it can effectively improve each monomer vitamin, mixture homogeneity of the minerals in nutrient powder product, guarantee that finished product meets evenly distributing for national standard and nutrient.
Description
Technical field
The present invention relates to the full nutrition special medicine purposes formula powder of tumour and its preparation fields, and in particular to a kind of improve is swollen
The full nutrient formulation of tumour of its preparation of the preparation process of the mixture homogeneity of micronutrient and application in the full nutrient formulation powder of tumor
Powder.
Background technique
Special medicine purposes formula food generally provides whether nutrient can be divided into three categories comprehensively by it: non-full nutrition is special
Different medical usage formula food, full nutrition special medicine purposes formula food and specific full nutrition special medicine purposes formula food
Product.
The full nutrient formulation powder of tumour belongs to specific full nutrition special medicine purposes formula food, in the full nutrient formulation powder of tumour
Formula design process in, because regulation limitation product in accounting of the part vitamin and mineral in finished product be 1/106~
1/108, and their addition manner is vitamin or minerals monomer directly adds or raw material monomer is using maltodextrin etc.
It is added after dry-mixed amplification；It on the other hand may be due to the physico-chemical property of itself, such as raw material particle size, density and other raw materials
Compared to there are bigger differences.It is detected through test of many times, nutrient includes vitamin A, vitamin D, vitamin K, vitamin B12、
Biotin, copper, selenium, during tumour full nutrition special medicine purposes formula powder, mixture homogeneity is detected in product for they
RSD result is distributed very uneven in the product 6%~15%.The problem also has become in the dry-mixed production industry of powder and shares
There are phenomenons.
In recent years, it around the mixing resultant for improving powder, is also deepening continuously always to the mixing mechanism research of powder.
It is generally believed that whether the mixing of each nutrient uniformly related with many factors, include mixing apparatus, incorporation time, feeding sequence,
The physico-chemical property etc. of each component, such as: CN 207187602U discloses a kind of uniformly mixed powder blenders,
CN207203927U discloses a kind of uniformly mixed batching kettle, CN201210174763 disclose a kind of vitamin powder and its
Preparation method, but have no and have been reported that raw material and machine cladding feed change physico-chemical property processed goes to improve battalion again by spray drying
Support the research of element mixture homogeneity.
Summary of the invention
The full nutrient formulation powder of tumour belongs to specific full nutrition special medicine purposes formula food, in the formula of tumour formula powder
In design process, the accounting that regulation limits part vitamin and mineral in product is very small, and then to product mix in producing
Uniformity detection RSD value has specific regulation again.Since the vitamin and mineral of part addition belongs to micro addition, and simultaneously
Often raw material particle size is unevenly distributed the vitamin and mineral of the micro addition in the part, leads to final products in actual production
Mixture homogeneity is unqualified, gained knot after the partial size of vitamin and mineral raw material and Density Detection used in product formula
Shown in the following Tables 1 and 2 of fruit.
Each raw material particle size testing result of table 1
Each material density testing result of table 2
It can be seen that different types of feed particles have different partial size and density, but the density contrast between variety classes is most very much not
More than 3 times, and partial size difference is maximum up to as many as 10 times, and the influence density to mixing resultant can not show a candle to partial size.
It is prepared in the way of the prior art, RSD is not ideal enough.Below test be in the way of the prior art into
Row preparation.Each raw material is finished and according to formula ratio weighing according to PURE WHEY 22%, medium chain triglyceride microcapsule powder
20%, linseed oil microcapsule powder 5%, formulated food additive (vitamin) 2%, fish oil microcapsule powder 1.5%, oligofructose
4.5%, formulated food additive (macro mineral) 3.8%, L-Leu 0.8%, essence for food 1.8%, L-arginine
1.2%, sunflower oil microcapsule powder 15%, maltodextrin 22.4% sequence be successively added into three-dimensional mixer, with
12rpm mixing 15min.Vitamin A, vitamin D, vitamin K, vitamin B are detected after mixing12, biotin, copper, selenium is in product
In content, as a result see the table below 3, it can be seen that RSD is in 6%~15% range.
Each nutrient testing result (n=10) of table 3
| Nutrient | Unit | Theoretical value (/ 100g) | Mean value | RSD/% |
| Vitamin A | μg RE | 505 | 508.9 | 12.1 |
| Vitamin D | μg | 6.8 | 6.4 | 7.9 |
| Vitamin K | μg | 32 | 35.1 | 6.5 |
| Vitamin B12 | μg | 3.1 | 3.4 | 14.8 |
| Biotin | μg | 20 | 23.5 | 7.3 |
| Copper | μg | 400 | 372 | 10.0 |
| Selenium | μg | 33.5 | 34.8 | 11.2 |
For above-mentioned problem, present invention research simultaneously discloses a kind of tumors of nutrients formula being prepared again by raw material
Powder, and preparation method thereof.From raw material itself, feed change materialization is coated by being spray-dried again raw material and machine processed
Matter guarantees that finished product meets national standard to improve each monomer vitamin, mixture homogeneity of the minerals in nutrient powder product
With evenly distributing for nutrient.
The present invention provides a kind of preparation process thereof containing powder, includes the following steps:
1) by liposoluble vitamin microencapsulation embedding treatment needed for preparation of the preparation containing powder；
2) will preparation the preparation containing powder needed for water soluble vitamin dissolution mixing after crystallizing and drying, after crushing again into
The processing of row cladding；
3) microelement needed for preparation of the preparation containing powder is pulverized respectively, then carries out cladding processing.
The liposoluble vitamin are as follows: vitamin A, vitamin D and vitamin K, water soluble vitamin are vitamin B12With
Biotin, the microelement are copper and selenium.
Step 1) the liposoluble vitamin microencapsulation embedding treatment includes mixing liposoluble vitamin, after shearing homogeneous
It is spray dried to liposoluble vitamin mixture, control partial size: 50 μm of D50 <, 180 μm of D90 <.
Water soluble vitamin mixture is obtained after step 2) the water soluble vitamin cladding, control partial size: 50 μm of D50 <,
180 μm of D90 <.
Each microelement covering body is respectively obtained after step 3) the microelement cladding, control partial size: 60 μm of D50 <,
160 μm of D90 <.
The liposoluble vitamin mixture includes liposoluble vitamin 5~55%, pungent dilute base succinic acid starch sodium 28%
~65%, assist wall material 3~20%, emulsifier 0.5%~2.0%, antioxidant 0.1%~2.0%.
The auxiliary wall material is one or more of sodium alginate, gelatin, Arabic gum, casein.
The water soluble vitamin mixture uses maltodextrin to be coated for parent.
The microelement covering body uses maltodextrin to be coated for parent.
The preparation containing powder is the preparation comprising liposoluble vitamin, water soluble vitamin and microelement, excellent
Select tumors of nutrients formula powder.
The present invention also provides the full nutrient formulation powder of tumour of application above-mentioned preparation process preparation.
Beneficial effects of the present invention: the preparation containing powder is handled using technique of the invention, obtained preparation
Each component mixes more evenly.The present invention is proved using technique of the invention with example first to the liposoluble in the full nutrient formulation powder of tumour
Property vitamin, water soluble vitamin and microelement are respectively processed, and each nutritional ingredient can be made to mix more uniform,
RSD is greatly improved 1%~4%, 6%~15% compared with the prior art.
Specific embodiment
Embodiment 1
Retinol1 3.7%, vitamin D 0.18%, vitamin K 0.9% are mixed as oily phase, are added anti-oxidant
Agent -- sodium ascorbate 0.2%)；Pungent dilute base succinic acid starch sodium 10.5% assists wall material sodium alginate and casein total
8.8%, emulsifier phosphatidase 0 .7% are dissolved in 50% water, are sheared after water phase and an oil phase is mixed, are spray-dried after homogeneous
At product.Pressure is 35MPa in homogenizing step, and 2 times, spray drying EAT is 175 DEG C, and leaving air temp is 90 DEG C, control
The partial size D50 of above-mentioned spray dried products is 48.5 μm, and D90 is 165.3 μm, obtains mixtures of fat-soluble vitamins.
Embodiment 2
It include B by water soluble vitamin120.16%, biotin 1.0% after being dissolved with water, is added dropwise in brilliant kettle, knot
Brilliant kettle stirring rate is 80~120rpm, and mode is added dropwise and is added dropwise for speed change, 8~10mL/min to last 1 by most~
2mL/min, 1.5~3.5h of rearing crystal time, solution concentration are 1.0~1.4wt%, and gained mixture is dried in vacuo, true
Reciprocal of duty cycle 0.05~0.10MPa, it is dry to moisture content < 5% under the conditions of 35~55 DEG C, it is then 1.12% by gained mixture,
Being pulverized be D10 to partial size is 0.41~0.58 μm, and D50 is 2.7~3.5 μm, and D90 is 3.7~5.2 μm, further
It is coated with high-speed flow impinging particle composite system, parent is maltodextrin (additive amount be mixture 8.5 times), the mistake
Journey high speed air-flow machine blade frequencies are 35Hz, and the cladding time is 10min, and partial size D50 is 38.5 μm, and D90 is 142.5 μm,
Obtain the mixture of water soluble vitamin and biotin.
Embodiment 3
It is 0.45~0.65 μm that obtained finely divided partial size, which is D10, after copper sulphate is pulverized, D50 is 2.8~
3.8 μm, D90 is 4.0~5.5 μm, is coated with high-speed flow impinging particle composite system, and parent is maltodextrin (with sulphur
Sour copper ratio is 7.3:1), high-speed flow robot blade frequency is 40Hz during being somebody's turn to do, and the cladding time is 10min, and partial size D50 is
51.3 μm, D90 is 156.7 μm, then the copper mine substance prepared.
Embodiment 4
It is 0.45~0.65 μm that the finely divided partial size obtained after sodium selenite is pulverized, which is D10, D50 2.8
~3.8 μm, D90 be 4.0~5.5 μm, coated with high-speed flow impinging particle composite system, parent be maltodextrin (with
The ratio of sodium selenite is 7.6:1), high-speed flow robot blade frequency is 40Hz during being somebody's turn to do, and the cladding time is 10min, grain
Diameter D50 is 53.8 μm, and D90 is 142 μm, then the selenium minerals matter prepared.
Embodiment 5
Each raw material is finished and according to formula ratio weighing according to PURE WHEY 22%, medium chain triglyceride microcapsule powder
20%, linseed oil microcapsule powder 5%, formulated food additive (vitamin) 2%, vitaminAD K mixture 2%, water soluble vitamin
Raw element B12With biotin mixture 2.5%, fish oil microcapsule powder 1.5%, oligofructose 4.5%, formulated food additive (magnanimity mine
Substance) 3.8%, again copper mine substance 1.0% processed, again selenium minerals matter 1.0% processed, L-Leu 0.8%, essence for food 1.8%,
L-arginine 1.2%, sunflower oil microcapsule powder 15%, maltodextrin 15.9% sequence be successively added into three-dimensional mixer
It is interior, with 12rpm mixing 15min.
Mixed sample is taken to carry out mixture homogeneity detection, testing result is as shown in table 4 below:
Each nutrient testing result (n=10) of table 4
| Nutrient | Unit | Theoretical value (/ 100g) | Mean value | RSD/% |
| Vitamin A | μg RE | 505 | 523.5 | 3.32 |
| Vitamin D | μg | 6.8 | 7.2 | 3.18 |
| Vitamin K | μg | 32 | 30.8 | 3.42 |
| Vitamin B12 | μg | 3.1 | 3.3 | 3.68 |
| Biotin | μg | 20 | 22 | 2.86 |
| Copper | μg | 400 | 390 | 1.94 |
| Selenium | μg | 33.5 | 33.1 | 2.58 |
Embodiment 6
Each raw material is finished according to formula ratio weighing (with embodiment 5), and according to PURE WHEY, medium chain triglyceride
Microcapsule powder, linseed oil microcapsule powder, formulated food additive (vitamin), vitaminAD K mixture, vitamin B12And biotin
Mixture, fish oil microcapsule powder, oligofructose, formulated food additive (macro mineral), again copper processed, again selenium processed, L-Leu,
Essence for food, L-arginine, sunflower oil (microcapsule powder), maltodextrin sequence be successively added into three-dimensional mixer
It is interior, with 12rpm mixing 20min.
Mixed sample is taken to carry out mixture homogeneity detection, testing result is as shown in table 5 below:
Each nutrient testing result (n=10) of table 5
Embodiment 7
Each raw material is finished according to formula ratio weighing (with embodiment 5), and according to PURE WHEY, linseed oil micro-capsule
Powder, vitaminAD K mixture, medium chain triglyceride microcapsule powder, formulated food additive (vitamin), vitamin B12And biotin
Mixture, fish oil microcapsule powder, again copper processed, again selenium processed, oligofructose, formulated food additive (macro mineral), L-Leu,
Essence for food, L-arginine, sunflower oil (microcapsule powder), maltodextrin sequence be successively added into three-dimensional mixer
It is interior, with 10rpm mixing 15min.
Mixed sample is taken to carry out mixture homogeneity detection, testing result is as shown in table 6 below:
Each nutrient testing result (n=10) of table 6
| Nutrient | Unit | Theoretical value (/ 100g) | Mean value | RSD/% |
| Vitamin A | μg RE | 505 | 510.9 | 2.77 |
| Vitamin D | μg | 6.8 | 6.9 | 3.36 |
| Vitamin K | μg | 32 | 33.1 | 2.98 |
| Vitamin B12 | μg | 3.1 | 2.7 | 2.46 |
| Biotin | μg | 20 | 19 | 3.01 |
| Copper | μg | 400 | 418 | 1.17 |
| Selenium | μg | 33.5 | 32.1 | 2.63 |
Embodiment 8
Each raw material is finished according to formula ratio weighing (with embodiment 5), and according to PURE WHEY, medium chain triglyceride
Microcapsule powder, linseed oil microcapsule powder, formulated food additive (vitamin), vitaminAD K mixture, vitamin B12And biotin
Mixture, fish oil microcapsule powder, oligofructose, formulated food additive (macro mineral), again copper processed, again selenium processed, L-Leu,
Essence for food, L-arginine, sunflower oil (microcapsule powder), maltodextrin sequence be successively added into three-dimensional mixer
It is interior, with 10rpm mixing 25min.
Mixed sample is taken to carry out mixture homogeneity detection, testing result is as shown in table 7 below:
Each nutrient testing result (n=10) of table 7
| Nutrient | Unit | Theoretical value (/ 100g) | Mean value | RSD/% |
| Vitamin A | μg RE | 505 | 535.3 | 2.05 |
| Vitamin D | μg | 6.8 | 7.1 | 2.16 |
| Vitamin K | μg | 32 | 30.9 | 2.37 |
| Vitamin B12 | μg | 3.1 | 3.4 | 3.47 |
| Biotin | μg | 20 | 23 | 3.12 |
| Copper | μg | 400 | 425 | 2.79 |
| Selenium | μg | 33.5 | 34.1 | 1.83 |
Embodiment 9
Each raw material is finished according to formula ratio weighing (with embodiment 5), and according to PURE WHEY, medium chain triglyceride
Microcapsule powder, vitaminAD K mixture, vitamin B12With biotin mixture, linseed oil microcapsule powder, formulated food additive
(vitamin), fish oil microcapsule powder, oligofructose, L-Leu, essence for food, formulated food additive (macro mineral),
Again copper processed, L-arginine, again selenium processed, sunflower oil (microcapsule powder), maltodextrin sequence be successively added into three-dimensional hybrid
In machine, with 15rpm mixing 12min.
Mixed sample is taken to carry out mixture homogeneity detection, testing result is as shown in table 8 below:
Each nutrient testing result (n=10) of table 8
| Nutrient | Unit | Theoretical value (/ 100g) | Mean value | RSD/% |
| Vitamin A | μg RE | 505 | 550.4 | 3.61 |
| Vitamin D | μg | 6.8 | 7.4 | 3.03 |
| Vitamin K | μg | 32 | 33.6 | 2.94 |
| Vitamin B12 | μg | 3.1 | 3.4 | 3.13 |
| Biotin | μg | 20 | 24 | 2.77 |
| Copper | μg | 400 | 403 | 2.01 |
| Selenium | μg | 33.5 | 32.5 | 1.31 |
By above-mentioned test result it is found that for mixing non-uniform vitamin A, vitamin D, vitamin K, vitamin B12、
After biotin, copper, selenium are using above method processing, it is remarkably improved mixture homogeneity, RSD is respectively less than 5%, compared with before,
It significantly improves, it is ensured that it is balanced that product can meet the nutrition of regulation demand and eater during production is with storage.
Above-mentioned detailed description is illustrating for one of them possible embodiments of the present invention, the embodiment not to
The scope of the patents of the invention is limited, all equivalence enforcements or change without departing from carried out by the present invention are intended to be limited solely by the technology of the present invention
In the range of scheme.
Claims (10)
1. a kind of preparation process thereof containing powder, which comprises the steps of:
1) by liposoluble vitamin microencapsulation embedding treatment needed for preparation of the preparation containing powder；
2) it by crystallizing and drying after water soluble vitamin dissolution mixing needed for preparation of the preparation containing powder, is wrapped again after crushing
Cover processing；
3) microelement needed for preparation of the preparation containing powder is pulverized respectively, then carries out cladding processing.
2. according to claim 1 containing the preparation process thereof of powder, which is characterized in that the fat-soluble dimension life of step 1)
Plain microencapsulation embedding treatment includes mixing liposoluble vitamin, being spray dried to liposoluble vitamin mixing after shearing homogeneous
Body, control partial size: 50 μm of D50 <, 180 μm of D90 <.
3. the preparation process thereof according to claim 1 containing powder, which is characterized in that the step 2) water soluble vitamin
Water soluble vitamin mixture, control partial size: 50 μm of D50 <, 180 μm of D90 < are obtained after raw element cladding.
4. the preparation process thereof according to claim 1 containing powder, which is characterized in that the step 3) microelement
Each microelement covering body, control partial size: 60 μm of D50 <, 160 μm of D90 < are respectively obtained after cladding.
5. the preparation process thereof according to claim 2 containing powder, which is characterized in that the liposoluble vitamin is mixed
Zoarium includes liposoluble vitamin 5~55%, and pungent dilute base succinic acid starch sodium 28%~65% assists wall material 3~20%, emulsification
Agent 0.5%~2.0%, antioxidant 0.1%~2.0%.
6. the preparation process thereof according to claim 5 containing powder, which is characterized in that the auxiliary wall material is seaweed
One or more of sour sodium, gelatin, Arabic gum, casein.
7. the preparation process thereof according to claim 3 containing powder, which is characterized in that the water soluble vitamin is mixed
Zoarium uses maltodextrin to be coated for parent.
8. the preparation process thereof according to claim 4 containing powder, which is characterized in that the microelement covering body
Maltodextrin is used to be coated for parent.
9. the preparation process thereof according to claim 8 containing powder, which is characterized in that the preparation containing powder
For the tumors of nutrients formula powder comprising liposoluble vitamin, water soluble vitamin and microelement.
10. the full nutrition of tumour of the preparation process thereof preparation according to any one of claims 1 to 8 containing powder is matched
Fang Fen, which is characterized in that the liposoluble vitamin are as follows: vitamin A, vitamin D and vitamin K, water soluble vitamin are dimension
Raw element B12And biotin, the microelement are copper and selenium.
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| CN114259045A (en) * | 2022-01-04 | 2022-04-01 | 烟台大学 | Sea cucumber intestine and egg nutrition supplement for tumor patients and preparation method thereof |
| CN115252577A (en) * | 2022-08-11 | 2022-11-01 | 郑州瑞普生物工程有限公司 | Vitamin B12 microcapsule powder, preparation method thereof and solid preparation |
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