CN109965273A - A kind of children's hyperkinetic syndrome tailored version clinical nutrition formula and preparation method thereof - Google Patents

A kind of children's hyperkinetic syndrome tailored version clinical nutrition formula and preparation method thereof Download PDF

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CN109965273A
CN109965273A CN201910267975.3A CN201910267975A CN109965273A CN 109965273 A CN109965273 A CN 109965273A CN 201910267975 A CN201910267975 A CN 201910267975A CN 109965273 A CN109965273 A CN 109965273A
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powder
children
vitamin
oil
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尤俊
季敬东
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Shanghai Olympic Medical Biotechnology Co Ltd
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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L17/00—Food-from-the-sea products; Fish products; Fish meal; Fish-egg substitutes; Preparation or treatment thereof
    • A23L17/20—Fish extracts
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/115—Fatty acids or derivatives thereof; Fats or oils
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/115—Fatty acids or derivatives thereof; Fats or oils
    • A23L33/12—Fatty acids or derivatives thereof
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/16—Inorganic salts, minerals or trace elements
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17—Amino acids, peptides or proteins
    • A23L33/175—Amino acids
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/40—Complete food formulations for specific consumer groups or specific purposes, e.g. infant formula
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

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Abstract

The present invention relates to a kind of children's hyperkinetic syndrome tailored version clinical nutrition formulas comprising: 10-25 parts of protein, 3-15 parts of fat, 30-60 parts of carbohydrate, 5-25 parts of dietary fibers, 2-5 parts of macroelements, 0.1-0.4 parts of microelements, 0.000001-0.00001 parts of liposoluble vitamins, 0.05-0.3 parts of water soluble vitamins, 0.01-3 parts of integration of drinking and medicinal herbs ingredients, 0.5-3 parts of natural plants compounds and 0.01-3 parts of new resource foods；The invention further relates to the preparation methods of above-mentioned clinical nutrition formula.Pass through the screening and proportion of said components, the present invention is by selecting reasonable basal nutrient element, using the proportion of general equilibrium, the supplement daily required necessary nutritional ingredient of children's hyperkinetic syndrome patient comprehensively, and the nutrient formulation is easier to be absorbed by children's hyperkinetic syndrome people digest, to improve the memory of patient, concentration and study idea, and stablize patient mood, and alleviate and treat the symptom of related hyperactivity, to improve the psychological problems of patient, patient is made to be easier to incorporate the daily life of normal population.

Description

A kind of children's hyperkinetic syndrome tailored version clinical nutrition formula and preparation method thereof
Technical field
The present invention relates to special medicine purposes formula food fields, and in particular to a kind of children's hyperkinetic syndrome tailored version clinic battalion Support formula and preparation method thereof.
Background technique
Children's hyperkinetic syndrome is also known as attention deficit hyperactivity disorder (ADHD) or minimal brain dysfunciton syndrome, is a kind of normal The child behavior abnormal diseases seen, be mainly shown as it is apparent pay attention to disorientation and persistence of attention is of short duration, hyperactivity hyperkinesia, Mood is inflammable, behavior is got excited with difficulty of learning and conduct disorder.It is biology-psychology-society that most scholars, which accept ADHD, The disease type that factor cooperatively forms.Biological factor includes biochemistry, science of heredity, immunology, nervous system development barrier Hinder, Electroencephalo, iconography etc..
Inherent cause plays an important role in hyperactivity morbidity.Congenital constitution defect and organs abnormality, chromosome are different Often, the inherent causes such as mental disease of parent can influence the brain function of child to some extent, cause its congenital constitution defect, thus Cause to move more.Mother, which has abnormal pregnancy history, premature labor or postmature delivery and baby to be in a bad state of health in young period, causes ADHD illness rate to increase Height, may be related with children's impaired brain development caused by unfavorable factor.Family factors include home environment, home education, father Female schooling, relationship between parents and emotion.Home environment is the principal element for influencing Children's psychological development, good home environment It is avoided that the generation of children ADHD or mitigates hyperactivity shape, bad domestic environment is to inspire the basis of hyperactivity.
According to incompletely statistics, domestic ADHD disease incidence is increased, it is now recognized that disease incidence is about 3%~5%, Nan Haifa Sick rate is about 3 times of girl, wherein the symptom of about 50%~60% infant can continue to it is adult in addition it is lifelong in spite of illness, but 80% ADHD patient do not obtain formal diagnosis.
The main clinical manifestation of ADHD are as follows: (1) attention deficit disorder: children's attention with this disease is obviously compared under child of the same age Drop, not interested to the things around at one's side, upper class hour likes gazing around, be unable to the attention of oneself in complete set specially cause in Attention will not be absorbed in thing by something by strong impulse.For disease in school age children, on classroom Performance just seem more prominent, be embodied in do not pay attention to paying attention to the class, be absent-minded, the symptoms such as thought is sneaked away；(2) activity Degree: the children with ADHD most it is outstanding performance be exactly it is active, after illness children's activity than previously obviously increases.With the age Increase, more dynamic, active habits of infant persistently exist.On often just sat down after class or just stand shortly can be automatic Left and right activity is got up, and does not stop to do various little tricks on classroom, after lower jump of leaping up when on foot, jump front jumping, a variety of occasions Under behavior off one's feet；(3) cacesthesia: perception is blunt, all more of the same age to the feeling of things, discrimination, elaborative faculty Youngster is low.Constantly, not accurate enough to the analysis ability of things, such as: proper motion is normal for mistake often for this infant in daily life Oneself is injured, concept of space is unclear, and things is out of one's reckoning, for sound, pain etc. without stronger feeling etc.；(4) get excited, The disturbance of emotion: often mood is apt to change for ADHD infant, will be generated impulsive action by after a dot environmental stimuli, sometimes excited It dances for joy, love cries and screams, flies into a rage sometimes, and mood constantly and irregularly changes.Disease in school age children is usually quarrelled or is fought with classmate, and thing is encountered Just make decision when feelings without pondering deeply, follow one's bent, do at will, not only cause itself behavior disorder, return around Other people cause adverse effect；(5) adapt to obstacle: ADHD infant individual character is prominent, advocates individualistic heroism.Be unwilling and other Child of the same age plays together, to control other people playing together, can not harmoniously live in collective, class with other classmates Together, often incompatible with the academic environment of class due to inharmonious with classmate's relationship, therefore, it is difficult to pleasant with classmate Life, study are together.Such situation makes infant be easy to be isolated by classmate, it is easy to infant heart suffering is caused, when the time is long Infant becomes unsociable and eccentric, cannot psychologically incorporate in collective livelihood, the management according to teacher, school of being also unwilling in behavior Regulation is done things, and is considered bad student by others in school；(6) difficulty of learning: although ADHD infant intelligence is learned in normal range (NR) The main reason for difficult is practised one is the impairment of itself, makes its school grade be lower than normal child of the same age mostly；Secondly infant It cannot conscientiously be paid attention to the class on most classroom, learning efficiency is decreased obviously, especially the knowledge of natural sciences class, such as calculate, think deeply etc. Learn relative difficulty.
Human nutrition situation and the relationship of Mental health more and more cause researcher note that also constantly there is scholar's report There are certain correlations with ADHD for road children's adolescent nutrition situation.American scholar Harding is in 10 ADHD children taking benefits His woods is given in the comparative study of diet supplement with 10 ADHD children and finds, food replenish improve ADHD child attention and It is effective in automatic control, and propose may there is same function with using ritalin drug therapy using food supplementary therapy ADHD Effect.There is provided in the diet of supplement includes: essential fatty acid, phosphatide, vitamin, minerals, nutrient for plants, amino acid etc.. The pathogenesis and unknown etiology as yet of ADHD, larger arguement are whether acquired environment has an impact to it.It focuses mostly in discussion Gene, society and family factors, Neuropsychological Characteristics etc..With deepening continuously to human spirit's psychological problems research, people Increasingly find that the nutrition condition of itself plays highly important role.
Treatment children's hyperkinetic syndrome relatively conventional at present is Chinese medicine composition, such as China CN104474341B is disclosed A kind of pharmaceutical composition for treating children's hyperkinetic syndrome comprising 15-25 parts of the fruit of glossy privet, 10-20 parts of fructus lycii, oyster 10-18 Part, 8-16 parts of mother-of-pearl, 16-24 parts of Os Draconis, 12-26 parts of Fructus Tritici Levis, 6-12 parts of Radix Glycyrrhizae, 10-16 parts of jujube, Radix Codonopsis 8-14 Part, 10-16 parts of the seed of Oriental arborvitae, 10-20 parts of Radix Polygalae, Radix Ophiopogonis 10-20 part, but it is not directed to necessary to human body more comprehensively Nutriment is not able to satisfy the daily demand of children's hyperkinetic syndrome patient, therefore, develops a facing for children's hyperkinetic syndrome Bed nutrition product is particularly important.
Summary of the invention
The purpose of the present invention is to overcome the defects in the prior art, provides a kind of clinical nutrition for children's hyperkinetic syndrome Product helps children to improve hyperactivity shape, the attention of children is improved, in favor of the healthy growth of infant.
To achieve the above object, the present invention adopts the following technical scheme:
The first purpose of the invention is to provide a kind of children's hyperkinetic syndrome tailored version clinical nutrition formulas, which is characterized in that Including following component and its parts by weight: 10-25 parts of protein, 3-15 parts of fat, 30-60 parts of carbohydrate, 5-25 portions of meals Eat fiber, 2-5 parts of macroelements, 0.1-0.4 parts of microelements, 0.000001-0.00001 parts of liposoluble vitamins, 0.05- The new money of 0.3 part of water soluble vitamin, 0.01-3 parts of integration of drinking and medicinal herbs ingredients, 0.5-3 parts of natural plants compounds and 0.01-3 parts Source food.
In order to advanced optimize above-mentioned clinical nutrition formula, technical measures adopted by the present invention further include:
Further, the protein be selected from PURE WHEY, soybean protein isolate, Isin glue collagen peptide, whole milk powder, At least one of dried whole-egg, lactoferrin, colostrum, amino acid, protein peptides.
Wherein, the amino acid is selected from L-lysine-Pidolidone, Pidolidone, L-arginine, L-Trp, L- paddy At least one of glutamine, taurine, Valine, l-Isoleucine, L-Leu, branched-chain amino acid powder；The albumen Peptide is selected from soybean oligopeptide, wheat protein peptide, pupa albumen peptide, ocean fish oligopeptide powder, laughable peptide, amino peptide, ovalbumin At least one of peptide.
Further, the protein includes PURE WHEY, soybean protein isolate, Lyophilized Bovine Colostrums, branch ammonia Base acid powder, taurine.
Further, the fat includes saturated fatty acid, polyunsaturated fatty acid, monounsaturated fatty acids, OPO knot At least one of structure rouge, DHA, EPA, ARA, phosphatide, the more specifically described fat includes safflower seed oil, walnut oil, peanut Oil, soybean oil, Ah's glycerol, olive oil, tea oil, oil and fat of sacha inchi, olive oil, coconut oil, perilla herb oil, cupu oil, palm oil, ox Oil, cream, lard, medium chain triglyceride, lecithin, Purple Perilla Seed Oil etc.；More preferably perilla herb oil microcapsule powder.
Further, the carbohydrate includes fructose, rock sugar, lactose, maltodextrin, tapioca, resistant starch In at least two；More preferably maltodextrin.
Further, the dietary fiber includes inulin, konjaku flour, galactooligosaccharide, oligofructose, oligomeric different malt At least one of sugar, soybean polyoses, cyclodextrin, resistant dextrin, soybean fiber；It is highly preferred that the dietary fiber is resistance Dextrin and oligofructose.
Further, the macroelement is selected from calcium citrate, L-calcium lactate, calcium monohydrogen phosphate, K-IAO, citric acid At least one of sodium and magnesium gluconate；More preferably: magnesium gluconate, calcium, wherein calcium is with calcium citrate, L-calcium lactate And/or the form addition of calcium monohydrogen phosphate.
Further, the microelement is selected from ferrous gluconate, potassium iodide, zinc gluconate, sodium selenite, grape At least one of saccharic acid copper, chromium sulfate, manganese gluconate and sodium molybdate；More preferably: iron, zinc, wherein iron is with gluconic acid Ferrous and/or zinc gluconate form addition, zinc are added in the form of zinc gluconate.
Further, the liposoluble vitamin is selected from vitamin A, beta carotene, vitamin D3, vitamin E, dimension life Plain K1At least one of；More preferably: vitamin D3。
Further, the water soluble vitamin is selected from vitamin B1, vitamin B2, vitamin B6, vitamin B12, dimension life At least one of plain C, pantothenic acid, folic acid, niacin, choline, inositol, biotin；More preferably: vitamin B1, vitamin B2, dimension Raw element B6, vitamin C.
Further, the natural plants compound be selected from L-carnitine, Glucosamine, lutein, phytosterol, kind At least one of Lycopene, resveratrol, allicin；More preferably L-carnitine.
Further, the integration of drinking and medicinal herbs ingredient is selected from radish seed, fructus lycii, oyster, semen ziziphi spinosae, Radix Glycyrrhizae, arillus longan, Fu At least one of Siberian cocklebur, jujube, Chinese yam；More preferably: oyster, semen ziziphi spinosae, Radix Glycyrrhizae, arillus longan, Poria cocos, jujube, Chinese yam, specifically For 0.01-0.5 portions of oysters, 0.01-0.5 parts of semen ziziphi spinosaes, 0.01-0.5 portions of Radix Glycyrrhizaes, 0.01-0.5 portions of arillus longans, 0.01-0.5 parts Poria cocos, 0.01-0.5 portion jujube, 0.01-0.5 portions of Chinese yams.
Further, it is few to be selected from first milk basic protein, hydrolysis yolk powder, γ-aminobutyric acid, shell for the new resource food Sugar, eucommia Bark male flower, bamboo-leaves flavones, casein phosphopeptide, fish oil, avenabeta glucosan, Oligomeric manna sugar, Rosa roxburghii Tratt, yeast β-Portugal At least one of glycan, newborn mineral salt, pueraria root powder, Rosa roxburghii Tratt, xylo-oligosaccharide；It is highly preferred that the new resource food is γ-ammonia Base butyric acid, fish oil, wherein the fish oil uses fish oil microcapsule powder.
Further, above-mentioned nutrient formulation may also include nucleotide, be specially 5 ' monophosphate cytidines.
Further, above-mentioned nutrient formulation may also include diet essence, the diet essence be selected from cereal, beans, potato, At least one of greengrocery, Homonemeae, nut-seed class, fish and shrimp, poultry meat, fruits；The cereal is selected from rice At least one of powder, millet flour, black rice flour, coixlacrymajobi powder, corn flour, wheat germ powder, oatmeal, buckwheat；The beans At least one selected from peameal, mung bean flour, black bean powder, red bean powder, soy meal；The potato is mainly made of common yam rhizome powder；Institute State at least one of Vegetable powder in carrot meal, white radish powder, pumpkin powder, spinach powder, tomato meal, broccoli powder, balsam pear powder Kind；The Homonemeae is selected from least one of mushroom powder, Kelp Powder and tremella powder；The nut-seed class is selected from pumpkin seed powder At least one of with lotus nut starch；The fish and shrimp are selected from least one of salmon powder and cod meal；The poultry meat Selected from least one of chicken meal, powdered beef, pork liver powder and pig kidney powder；The fruits are selected from red date powder, longan powder, apple At least one of powder, cherry powder, citrus powder, pyrus nivalis powder.
Further, above-mentioned nutrient formulation may also include cycle of sixty years and heart, and additive amount is 0.5~2 part, has and mends Iron, zinc supplementation nourish heart, improve cranial nerve function, have significant curative effect to children's hyperkinetic syndrome is alleviated.
Further, the children's hyperkinetic syndrome tailored version clinical nutrition formula includes: maltodextrin, PURE WHEY, resists Property dextrin, oligofructose, soybean protein isolate, perilla herb oil microcapsule powder, magnesium gluconate, fish oil microcapsule powder, branched-chain amino acid powder, Oyster, semen ziziphi spinosae, Radix Glycyrrhizae, arillus longan, Poria cocos, jujube, Chinese yam, Lyophilized Bovine Colostrums, γ-aminobutyric acid, L-carnitine, calcium, Iron, zinc, vitamin D3, vitamin B1, vitamin B2, vitamin B6, vitamin C, taurine.
A second object of the present invention is to provide a kind of preparation sides of above-mentioned children's hyperkinetic syndrome tailored version clinical nutrition formula Method method comprising following steps:
Step 1) prepares fat powder, liposoluble vitamin powder and water soluble vitamin powder using micro-capsule embedding techniques End；
Step 2) mentioned using crushing, alcohol extracting, water, be spray-dried and sifting step prepares integration of drinking and medicinal herbs component powders；
Step 3) is smart by the protein of predetermined weight, carbohydrate, dietary fiber, macroelement, microelement, diet China, natural plants compound and new resource food are prepared into the powder that partial size is 150~250 μm respectively, if necessary Above-mentioned raw materials can be carried out in advance baking processing；
Step 4) is by step 1)~3) powder of preparation sterilize after mixing it is spare；
The mixed powder of step 4) is prepared into nutrient powder, nutrition emulsion, capsule according to conventional technical means by step 5) At least one of agent, tablet, pill or oral solution；
Wherein, step 1) -3) sequence can mutually replace.
Finally, the present invention relates to a kind of products prepared by above-mentioned children's hyperkinetic syndrome tailored version clinical nutrition formula, including Nutrient powder, nutrition emulsion, capsule, tablet, pill, oral solution etc..
In the above preparation method, wherein the raw material of the integration of drinking and medicinal herbs ingredient crushed, alcohol extracting concentration, water concentrate Contracting, and concentrate is subjected to spray drying, integration of drinking and medicinal herbs component powders are made；Wherein, the vitamin and fat are respectively by micro- Encapsulated processing is prepared into vitamin powder and fat powder.
Preferably, the preparation process of the integration of drinking and medicinal herbs component powders is as follows: using pulverizer to predetermined weight number Raw material is crushed, and the raw material of crushing is placed in container, and 7~8 times of 30~40% second that weight is raw material weight are added Alcohol is impregnated, is extracted 3 times, is merged alcohol extract and is concentrated into no alcohol taste；After the raw medicine dregs of a decoction fling to ethyl alcohol, it is original that weight, which is added, 3~4 times of water of material weight is impregnated, and carries out 15~20min of decoction to soak, filtering removal raw material leaves and takes decoction Liquid；Alcohol extract and decoction liquor after merging concentration, and it is spray-dried, it is same finally to prepare medicine food with 60~80 meshes point Derived components powder.
Preferably, specific step is as follows for the microencapsulation processing of the vitamin: 1) using liposoluble vitamin as core Material selects sodium carboxymethylcellulose, gelatin, carragheen, xanthan gum, Arabic gum, maltodextrin, lipoprotein, corn syrup, big Beans protein isolate, whole-fat milk powder, dietary fiber, inulin, PURE WHEY, oligoisomaltose, soybean fiber, lactose, rock sugar One of powder, emulsifier, stabilizer are a variety of as wall material, and high-pressure homogeneous emulsification is spraying instantaneous dry, with 60~80 meshes Divide and prepares liposoluble vitamin powder；2) using water soluble vitamin as core material, sodium carboxymethylcellulose, gelatin, OK a karaoke club are selected Glue, xanthan gum, Arabic gum, maltodextrin, lipoprotein, corn syrup, soybean protein isolate, whole-fat milk powder, dietary fiber, chrysanthemum One of powder, PURE WHEY, oligoisomaltose, soybean fiber, lactose, candy sugar powder, emulsifier, stabilizer or a variety of works For wall material, it is uniformly mixed, it is spraying instantaneous dry, water soluble vitamin powder is prepared with 60~80 meshes point.
Preferably, the specific implementation step of the micro-capsule embedding techniques of the fat is as follows: by fat, emulsifier, wall material with Water mixed dissolution prepares emulsion；After above-mentioned emulsion is stirred, emulsifying homogeneous processing is carried out, is then done by spraying Dry, screening prepares fat powder, and fat powder is compared with conventional grease, and dispersibility, water solubility, emulsibility, inoxidizability are all It improves a lot；Wherein, the emulsifier be selected from fatty acid glyceride (glyceride), methyl glycol fatty acid ester (propylene glycol ester), Sorbitan aliphatic ester (sorbitan acid), sucrose fatty ester (sucrose ester), lecithin, monoglyceride, one in Tween 80 Kind is a variety of；The wall material is selected from sodium carboxymethylcellulose, gelatin, carragheen, xanthan gum, Arabic gum, maltodextrin, rouge egg White, corn syrup, soybean protein isolate, whole-fat milk powder, dietary fiber, inulin, PURE WHEY, oligoisomaltose, soybean One of fiber, lactose, candy sugar powder, emulsifier, stabilizer are a variety of.
The present invention also provides a kind of preparation methods of above-mentioned a variety of disease tailored version clinical nutrition formulas of children, are wet process work Skill includes the following steps:
Step 1) prepare the protein containing predetermined weight number, fat, carbohydrate, dietary fiber, macroelement, Microelement, vitamin, integration of drinking and medicinal herbs ingredient, natural plants compound and new resource food raw material, in predetermined amount It in water, according to the physical behavior of raw material, is successively added according to sequencing, is stirred while addition, raw material is made Mixed emulsion；
The mixed emulsion temperature that step 1) obtains is maintained at 40-50 DEG C by step 2), and adjustment homogenization pressure protects it always It holds between 10-18Mpa, emulsifying homogeneous is carried out to mixed emulsion, is then placed emulsion in evaporator, with preset technology Parameter is concentrated, and is sterilized at 85-88 DEG C, and concentrate is obtained；
The concentrate that step 2) obtains is spray-dried by step 3), is crossed 60~80 meshes, is prepared into powder；Using upper It states powder and is prepared at least one of nutrient powder, nutrition emulsion, capsule, tablet, pill or oral solution.
Using the integration of drinking and medicinal herbs ingredient for including oyster, semen ziziphi spinosae, Radix Glycyrrhizae, arillus longan, Poria cocos, jujube, Chinese yam in the present invention； Wherein, it is rich in vitamin and minerals in oyster, is conducive to the effects of adjusting nerve, setting the mind at rest；Semen ziziphi spinosae has calming heart Sedative action；Radix Glycyrrhizae play the role of nourishing heart allay excitement, easing up the urgency with moist and sweet drugs；Arillus longan has tonifying heart and spleen, nourishing blood and tranquilization effect；Poria cocos has The effect of tranquilizing and allaying excitement；Jujube has the function of tonifying middle-Jiao and Qi, health care stomach, calms the nerves and enrich blood；Chinese yam has strengthening spleen and nourishing stomach, beneficial lung Effect.Have the function of alleviating each symptom of children's hyperkinetic syndrome patient after mentioned component compatibility synergy and improves its concentrated force.
Compared with prior art, the invention has the following advantages:
Children's hyperkinetic syndrome tailored version clinical nutrition formula supplement addition zinc, magnesium, calcium of the present invention, zinc have a variety of lifes Object function such as participates in the composition of many enzymes, and required for the activity of enzyme；In protein synthesis and amino acid metabolism mistake Cheng Zhong and indispensable ingredient；Zinc has protective effect to nerve cell film integrality, the growth and brain function to normal brain activity Maintenance play an important role, become together with calcium, potassium, sodium central nervous system neurons excitatoty one it is key Instrumentality.Magnesium has different physiological roles, and a variety of enzyme systems can be activated to participate in the metabolism of body sugar, protein, fat.To mind Have through movable control, the transmitting of neural muscle excitability, the contraction of muscle, heart activation and antiotasis etc. important Effect；Discovered in recent years magnesia mixture is a kind of important neuroprotective agent and EAA antagonists, can remain neural thin The oxidative phosphorylation reaction of born of the same parents, the synthesis of protein and phosphatide, increase brain cell energy supply, reduce free radical and generate； Meanwhile reaction of the histocyte to insulin can be promoted, accelerate glucose clearance, the acidic metabolic for reducing cerebral apoplexy position produces Object, reduces the range of cerebral arterial thrombosis, to mitigate the damage of brain tissue.Calcium is the activator of neuron metabolism, works as mind When reaching the cynapse of nerve endings through impulsion, synaptic membrane generates action potential, membrane depolarization, calcium ion due to ion-transfer Stream enters cell in a manner of equilibrium potential difference, promotes neural vesicle to contact with synaptic membrane and passs to synaptic cleft release nerve Matter.The inside and outside transfer of calcium ion cell membrane in this course is necessary, while also relying on the concentration of calcium transfer to response intensity It is adjusted, reacts strong when calcium concentration is high, it is on the contrary then weak.Due to calcium nerve modulation effect to excitatory transmitter (second phthalein choline, Norepinephrine) and inhibitory transmitter (the light tryptamines of dopamine, 5-, γ-aminobutyric acid) effect having the same, therefore work as machine When body calcium deficiency, neurotransmitter regulator is affected, and the excitement of nervous system and inhibition function get muddled.Match simultaneously in the nutrition Fang Zhong, also addition vitamin C, to improve iron, calcium utilization participates in the effects of synthesizing neurotransmitter.
Children's hyperkinetic syndrome tailored version clinical nutrition formula of the present invention also adds branched-chain amino acid, in protein in body Also important adjustment effect is played in matter, carbohydrate and lipid-metabolism.Branched-chain amino acid decline shows body catabolism Increase, illustrates that body is in stress situation, energy consumption increases；This decline can influence protein synthesis simultaneously, cause immune function decline And compromised brain function.And add γ-aminobutyric acid, γ-aminobutyric acid belongs to inhibitory aminoacid (IAA), IAA metabolism and/or Change to brain transport process, results in the change of nervous function, thus there is the increased symptom of excitability, it is such as more Dynamic, absent minded and impulsive action etc..
The present invention also adds fish oil, and omega-3 fatty acid is the essential component for constituting brain cell membrane, and maintenance brain is good for The important person who has rendered outstanding service of health, it can make chemical message, and successfully efficient communication is made in transmission between brain cell, and fish oil can not only increase Strong learning ability, memory and concentration, can also alleviate pressure.
The present invention is by selecting reasonable basal nutrient element, using the proportion of general equilibrium, while adding small with adjusting Integration of drinking and medicinal herbs ingredient, the natural plants chemical combination of youngster hyperactivity patient memory, concentration and study idea, stable patient mood etc. The specific nutrients such as object, new resource food, and adjust its proportion and carry out compatibility synergy with basal nutrient element, it is more that children are supplemented comprehensively The dynamic daily required necessary nutritional ingredient of disease patient, and the nutrient formulation is easier to be absorbed by children's hyperkinetic syndrome people digest, fills The effect of its each component is waved in distribution effectively guarantees nutrient necessary to patient's growth and development, and alleviates and treat related more The symptom of dynamic disease makes patient be easier to incorporate the daily life of normal population to improve the psychological problems of patient.
Specific embodiment
The present invention provides a kind of children's hyperkinetic syndrome tailored version clinical nutrition formula comprising following component and its parts by weight Number: 10-25 parts of protein, 3-15 parts of fat, 30-60 parts of carbohydrate, 5-25 parts of dietary fibers, 2-5 parts of macroelements, 0.1-0.4 parts of microelements, 0.000001-0.00001 parts of liposoluble vitamins, 0.05-0.3 parts of water soluble vitamins, 0.01-3 parts of integration of drinking and medicinal herbs ingredients, 0.5-3 parts of natural plants compounds and 0.01-3 parts of new resource foods.
With reference to embodiment, the specific embodiment of the present invention is further described.Following embodiment is only used for more Add and clearly demonstrate technical solution of the present invention, and not intended to limit the protection scope of the present invention.
Embodiment 1
Children's hyperkinetic syndrome tailored version clinical nutrition formula of the present invention includes maltodextrin 40g, PURE WHEY 10g, resistant dextrin 10g, oligofructose 10g, soybean protein isolate 8g, perilla herb oil microcapsule powder 5g, magnesium gluconate 3.5g, fish oil Microcapsule powder 2g, branched-chain amino acid powder 2g, oyster 0.5g, semen ziziphi spinosae 0.2g, Radix Glycyrrhizae 0.5g, arillus longan 0.2g, Poria cocos 0.5g, jujube 0.2g, Chinese yam 0.2g, Lyophilized Bovine Colostrums 0.5g, γ-aminobutyric acid 0.2g, L-carnitine 1g, calcium 0.37g, iron 0.17g, zinc 0.13g, vitamin D30.0000013g, vitamin B10.002g, vitamin B20.002g, vitamin B60.002g, dimension life Plain C0.198g, taurine 0.12g.
Embodiment 2
Children's hyperkinetic syndrome tailored version clinical nutrition formula of the present invention includes maltodextrin 40g, PURE WHEY 10g, resistant dextrin 10g, oligofructose 10g, soybean protein isolate 8g, perilla herb oil microcapsule powder 5g, magnesium gluconate 3.5g, fish oil Microcapsule powder 0.02g, branched-chain amino acid powder 2g, oyster 0.5g, semen ziziphi spinosae 0.2g, Radix Glycyrrhizae 0.5g, arillus longan 0.2g, Poria cocos 0.5g, Jujube 0.2g, Chinese yam 0.2g, Lyophilized Bovine Colostrums 0.5g, γ-aminobutyric acid 0.01g, L-carnitine 1g, calcium 0.37g, iron 0.17g, zinc 0.13g, vitamin D30.0000013g, vitamin B10.002g, vitamin B20.002g, vitamin B6 0.002g, vitamin C 0.198g, taurine 0.12g.
Embodiment 3
Children's hyperkinetic syndrome tailored version clinical nutrition formula of the present invention includes maltodextrin 40g, PURE WHEY 10g, resistant dextrin 10g, oligofructose 10g, soybean protein isolate 8g, perilla herb oil microcapsule powder 5g, magnesium gluconate 3.5g, fish oil Microcapsule powder 0.02g, branched-chain amino acid powder 2g, oyster 0.01g, semen ziziphi spinosae 0.01g, Radix Glycyrrhizae 0.01g, arillus longan 0.01g, Poria cocos 0.01g, jujube 0.01g, Chinese yam 0.01g, Lyophilized Bovine Colostrums 0.5g, γ-aminobutyric acid 0.01g, L-carnitine 1g, calcium 0.37g, iron 0.17g, zinc 0.13g, vitamin D30.0000013g, vitamin B10.002g, vitamin B20.002g, dimension life Plain B60.002g, vitamin C 0.198g, taurine 0.12g.
Embodiment 4
It is a kind of as embodiment 1~children's hyperkinetic syndrome described in embodiment 3 tailored version clinical nutrition formula preparation method such as Under:
1) powdered oil (powder fat) is prepared:
A) it prepares wall material aqueous solution: taking 8 grams of maltodextrin, 11 grams of whole-fat milk powder, dietary fiber 2 grams of (resistant dextrin), chrysanthemums 0.5 gram of powder, 5 grams of PURE WHEY, 0.5 gram of oligoisomaltose, 1 gram of soybean fiber, 0.2 gram of Arabic gum, 0.5 gram of lactose, 2 grams of candy sugar powder, 50 milliliters of water stir evenly (have ready conditions and heat while stirring to 60 DEG C, keep 30 minutes after be cooled to room temperature).
B) 0.1 gram (total solid concentration is 0.2%) is taken uniformly to be dissolved in (perilla herb oil in 4.69 milliliters of greases monoglyceride 4.69 milliliter).
C) 0.1 gram (total solid concentration is 0.2%) is taken uniformly to be dissolved in wall material aqueous solution Tween 80.
D) the wall material aqueous solution of the mixed plant grease and addition Over emulsfication agent Tween 80 of Over emulsfication agent monoglyceride will be added It is sufficiently mixed.
E) addition stabilizer agar takes 0.1 gram (total solid concentration be 0.2%) into after mixed solution, is settled to water 200 milliliters (total solid concentration be 25%), high speed dispersion 2 minutes under 20000r/min.
F) homogenization pressure is 25MPa, and homogeneous 3 times (every time 5 minutes), homogeneous emulsion is made.
G) emulsion obtained is spray-dried, inlet air temperature is 195 DEG C, and leaving air temp is 80 DEG C.Collect powder Grease (powder fat), i.e. perilla herb oil microcapsule powder；
The identical mode with step 1) is taken to prepare fish oil microcapsule powder.
2) integration of drinking and medicinal herbs component powders are prepared: being crushed, will be crushed using raw material of the pulverizer to predetermined weight number Raw material be placed in container, crushed using raw material of the pulverizer to predetermined weight number, the raw material of crushing be placed in container In, 4 times of 75% ethyl alcohol that weight is raw material weight is added, impregnated, extracted 2 times, merges alcohol extract and is concentrated into no alcohol Taste；After the raw medicine dregs of a decoction fling to ethyl alcohol, 6 times of the water that weight is raw material weight is added and is impregnated, soak is decocted 45min, filtering removal raw material, leaves and takes decoction liquor；Alcohol extract and decoction liquor after merging concentration, and it is spray-dried, Finally integration of drinking and medicinal herbs component powders are prepared with 60 meshes point；
3) it prepares vitamin powder: using the liposoluble vitamin of predetermined weight number as core material, selecting oligomeric different malt Sugar is used as wall material, carries out 2 emulsifying homogeneous processing under high pressure, and the emulsifying homogeneous time is 15min, is then instantaneously done by spraying It is dry, liposoluble vitamin powder is prepared with 80 meshes point；Using the water soluble vitamin of predetermined weight number as core material, wheat is selected Bud dextrin, oligoisomaltose are uniformly mixed as wall material, spraying instantaneous dry, prepare water soluble vitamin with 80 meshes point Powder；
4) by the protein of predetermined weight, carbohydrate, dietary fiber, macroelement, microelement, diet essence, Natural plants compound and new resource food are prepared into the powder that partial size is 200 μm respectively；(step 1) -4) sequence can phase Mutually replacement)
5) by step 1) -4) preparation powder sterilized after mixing in the similar devices such as mixing machine it is spare；
6) according to conventional technical means by the powder in step 5) be prepared into nutrient powder, nutrition emulsion, capsule, tablet, At least one of pill or oral solution.
In step 6), optionally increase suitable food thickening agent, food additives and related dosage form auxiliary material. The food thickening agent is guar gum, in xanthan gum, locust bean gum, konjac glucomannan, pectin, carragheen, agar, gelatin, Arabic gum At least one, the food additives be at least one of Aspartame, edible essence fragrance, brown sugar；More preferable OK a karaoke club Glue, Arabic gum, guar gum, Aspartame, edible essence fragrance.
Aforesaid operations step is both needed to carry out under the protection of inert gas, such as nitrogen, argon gas, helium etc., to prevent from producing The danger of green powder explosion.
It can be prepared into the classifications such as powdery, graininess, capsule shape, tablet shape, beverage according to the formula.
Embodiment 5
The present embodiment verifies influence of the nutrient formulation of the present invention to children's hyperkinetic syndrome.The present embodiment uses embodiment The nutrient powder and following comparative examples of 1 formula preparation:
Comparative example 1: the Chinese medicine composition of commercially available treatment children's hyperkinetic syndrome, by specification are taken；
Comparative example 2: the Western medicine ritalin of commercially available treatment children's hyperkinetic syndrome, by specification are taken；
Comparative example 3: not adding fish oil microcapsule powder and γ-aminobutyric acid, the battalion that remaining component is prepared by the formula of embodiment 1 Support powder；
Comparative example 4: not adding integration of drinking and medicinal herbs ingredient, the nutrient powder that remaining component is prepared by the formula of embodiment 1；
Comparative example 5: not adding macroelement, microelement and vitamin, remaining component is prepared by the formula of embodiment 1 Nutrient powder；
Comparative example 6: addition cycle of sixty years and each 0.8g of Pigs Hearts, cycle of sixty years and Pigs Hearts are all made of freeze-dried powder technology and are prepared into powder, The nutrient powder that remaining component is prepared by the formula of embodiment 1.
7 groups of experimental group of setting, children's hyperkinetic syndrome patient 20 of corresponding nutrient powder are voluntarily taken in every group of selection, and nutrient powder is every Day takes three times, brews 150mg every time.Each 10 parts of men and women of the patient that above-mentioned each experimental group uses, the age at 7~12 years old, The course of disease is 6 months~4 years, continuously takes related preparations 8 weeks, and carries out curative effect judgement with following standards:
(1) fully recover: cardinal symptom disappears, and mostly dynamic index score reduces > 80%, and school grade significantly improves, and is discontinued 0.5 year Efficacy consolidation；
(2) effective: cardinal symptom is obviously improved, and mostly dynamic index score reduces > 50%, and school grade has to be mentioned in various degree It is high；
(3) effectively: cardinal symptom improves, and mostly dynamic index score reduces > 30%, and school grade improves, but unstable；
(4) invalid: above-mentioned symptom and index without improvement or deteriorate.
The treatment results of above-mentioned experimental group are as shown in the table:
Group Recovery from illness It is effective Effectively In vain Total effective rate Total effective rate
Example 1 group 3 7 8 2 50% 90%
1 group of comparative example 2 6 5 7 40% 65%
2 groups of comparative example 1 8 3 8 45% 60%
3 groups of comparative example 2 6 7 5 40% 75%
4 groups of comparative example 1 5 7 7 30% 65%
5 groups of comparative example 1 4 12 3 25% 85%
6 groups of comparative example 3 8 6 3 55% 85%
As seen from the above table, compared with comparative example 1~2 (existing preparation), 1 nutrient formulation of embodiment and addition are pressed in the present invention Active cycle of sixty years and the nutrient powder of comparative example 6 nutrient formulation of Pigs Hearts preparation are that children's hyperkinetic syndrome patient has more excellent treatment Effect, and for comparative example 3~5, though having the effect of certain, its effect is slightly weaker than nutrient formulation of the present invention, This shows that each component combination and compatibility uses in the nutrient formulation of the invention used, produces synergistic beneficial effect.
Through the foregoing embodiment it is found that children's hyperkinetic syndrome tailored version clinical nutrition formula of the present invention is closed by selecting The basal nutrient element of reason using the proportion of general equilibrium, while adding to have and adjusting children's hyperkinetic syndrome patient memory, concentration With the specific nutrients such as study idea, the integration of drinking and medicinal herbs ingredient for stablizing patient mood etc., natural plants compound, new resource food, And adjust its proportion and carry out compatibility synergy with basal nutrient element, the daily required necessary nutrition of children's hyperkinetic syndrome patient is supplemented comprehensively Ingredient, and the nutrient formulation is easier the effect of being absorbed by children's hyperkinetic syndrome people digest, giving full play to its each component, effectively Guarantee nutrient necessary to patient's growth and development, and alleviate and treat the symptom of related hyperactivity, to improve the psychology of patient Problem makes patient be easier to incorporate the daily life of normal population.
Specific embodiments of the present invention are described in detail above, but it is only used as example, the present invention is not intended to limit In particular embodiments described above.To those skilled in the art, the equivalent modifications and replace that any couple of present invention carries out In generation, is also all among scope of the invention.Therefore, without departing from the spirit and scope of the invention made by equal transformation and repair Change, all should be contained within the scope of the invention.

Claims (10)

1. a kind of children's hyperkinetic syndrome tailored version clinical nutrition formula, which is characterized in that including following component and its parts by weight: 10-25 parts of protein, 3-15 parts of fat, 30-60 parts of carbohydrate, 5-25 parts of dietary fibers, 2-5 parts of macroelements, 0.1- 0.4 part of microelement, 0.000001-0.00001 parts of liposoluble vitamins, 0.05-0.3 parts of water soluble vitamins, 0.01-3 parts Integration of drinking and medicinal herbs ingredient, 0.5-3 parts of natural plants compounds and 0.01-3 parts of new resource foods；
Wherein, the protein includes PURE WHEY, soybean protein isolate, bovine colostrum, taurine, branched-chain amino acid powder； The new resource food includes γ-aminobutyric acid；Wherein, the integration of drinking and medicinal herbs at selected from radish seed, fructus lycii, oyster, semen ziziphi spinosae, At least one of Radix Glycyrrhizae, arillus longan, Poria cocos, jujube, Chinese yam.
2. a kind of children's hyperkinetic syndrome tailored version clinical nutrition formula according to claim 1, which is characterized in that the fat Including safflower seed oil, walnut oil, peanut oil, soybean oil, Ah's glycerol, olive oil, tea oil, oil and fat of sacha inchi, olive oil, coconut oil, At least one of perilla herb oil, cupu oil, palm oil, butter, cream, lard, medium chain triglyceride, lecithin, Purple Perilla Seed Oil.
3. a kind of children's hyperkinetic syndrome tailored version clinical nutrition formula according to claim 1, which is characterized in that the medicine food With derived components include: 0.01-0.5 portions of oysters, 0.01-0.5 parts of semen ziziphi spinosaes, 0.01-0.5 portions of Radix Glycyrrhizaes, 0.01-0.5 portions of arillus longans, 0.01-0.5 parts of Poria cocos, 0.01-0.5 portions of jujubes, 0.01-0.5 portions of Chinese yams.
4. a kind of children's hyperkinetic syndrome tailored version clinical nutrition formula according to claim 1, which is characterized in that described natural Plant compound is in L-carnitine, Glucosamine, lutein, phytosterol, lycopene, resveratrol, allicin At least one.
5. a kind of children's hyperkinetic syndrome tailored version clinical nutrition formula according to claim 1, which is characterized in that the constant Element includes calcium and magnesium, and the microelement includes zinc, and the water soluble vitamin includes vitamin C.
6. a kind of children's hyperkinetic syndrome tailored version clinical nutrition formula according to claim 1, which is characterized in that the diet Fiber includes inulin, konjaku flour, galactooligosaccharide, oligofructose, oligoisomaltose, soybean polyoses, cyclodextrin, resistance paste At least one of essence, soybean fiber.
7. a kind of children's hyperkinetic syndrome tailored version clinical nutrition formula according to claim 1, which is characterized in that the nutrition Formula may also include cycle of sixty years and heart, and additive amount is 0.5~2 part.
8. a kind of children's hyperkinetic syndrome tailored version clinical nutrition formula according to claim 1, which is characterized in that the children Hyperactivity tailored version clinical nutrition formula includes: maltodextrin, PURE WHEY, resistant dextrin, oligofructose, soybean separation protein White, perilla herb oil microcapsule powder, magnesium gluconate, fish oil microcapsule powder, branched-chain amino acid powder, oyster, semen ziziphi spinosae, Radix Glycyrrhizae, arillus longan, Fu Siberian cocklebur, jujube, Chinese yam, Lyophilized Bovine Colostrums, γ-aminobutyric acid, L-carnitine, calcium, iron, zinc, vitamin D3, vitamin B1, dimension life Plain B2, vitamin B6, vitamin C, taurine.
9. a kind of preparation method of such as children's hyperkinetic syndrome tailored version clinical nutrition formula according to any one of claims 1 to 8, It is characterized by comprising the following steps:
The preparation of micro-capsule embedding techniques is respectively adopted simultaneously in the fat, liposoluble vitamin, water soluble vitamin of step (1) predetermined weight It crosses 60~80 meshes and powder is made；
The integration of drinking and medicinal herbs ingredient of step (2) predetermined weight is mentioned by crushing, alcohol extracting, water, is spray-dried and cross 60-80 mesh and is made Powder；
Remaining component of step (3) predetermined weight is prepared into the powder that partial size is 150~250 μm respectively；
Step (4) sterilizes powder prepared by step (1)~(3) spare after mixing；
Direct-edible pharmaceutical formulation is made in step (4) mixed powder by step (5)；
Wherein, step (1)~(3) sequence can be replaced mutually；The pharmaceutical formulation include nutrient powder, nutrition emulsion, capsule, Tablet, pill, oral solution.
10. the preparation method of tailored version clinical nutrition formula is energized when production described according to claim 1~any one of 8, It is characterized in that, includes the following steps:
Step 1) prepares the protein containing predetermined weight number, fat, carbohydrate, dietary fiber, macroelement, micro Element, vitamin, integration of drinking and medicinal herbs ingredient, natural plants compound and new resource food raw material powder, in predetermined amount It in water, according to the physical behavior of raw material, is successively added according to sequencing, is stirred while addition, raw material is made Mixed emulsion；
The mixed emulsion that step 2) obtains step 1) carries out emulsifying homogeneous, concentrating sterilizing, obtains concentrate；
The concentrate that step 2) obtains is spray-dried by step 3), and sieving is prepared into powder, and above-mentioned powder is prepared into At least one of nutrient powder, nutrition emulsion, capsule, tablet, pill or oral solution.
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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110237062A (en) * 2019-07-10 2019-09-17 吉林农业大学 It is a kind of using gucosamine as the preparation that can enhance attention of regulator
CN115317507A (en) * 2022-09-19 2022-11-11 中国科学院海洋研究所 Application of low molecular weight fucoidan in preparation of anti-hyperactivity drugs
WO2024057139A1 (en) * 2022-09-14 2024-03-21 Abiogen Pharma Spa Composition comprising l-leucine and fish oil

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110237062A (en) * 2019-07-10 2019-09-17 吉林农业大学 It is a kind of using gucosamine as the preparation that can enhance attention of regulator
WO2024057139A1 (en) * 2022-09-14 2024-03-21 Abiogen Pharma Spa Composition comprising l-leucine and fish oil
CN115317507A (en) * 2022-09-19 2022-11-11 中国科学院海洋研究所 Application of low molecular weight fucoidan in preparation of anti-hyperactivity drugs

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