CN104605227A - Hollow capsule with health-care function - Google Patents

Hollow capsule with health-care function Download PDF

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Publication number
CN104605227A
CN104605227A CN201510019468.XA CN201510019468A CN104605227A CN 104605227 A CN104605227 A CN 104605227A CN 201510019468 A CN201510019468 A CN 201510019468A CN 104605227 A CN104605227 A CN 104605227A
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China
Prior art keywords
parts
capsules
methyl
alginate
carragheen
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Pending
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CN201510019468.XA
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Chinese (zh)
Inventor
何荣军
王茜
叶丽雅
施俊妃
孙培龙
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Zhejiang University of Technology ZJUT
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Zhejiang University of Technology ZJUT
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Priority to CN201510019468.XA priority Critical patent/CN104605227A/en
Publication of CN104605227A publication Critical patent/CN104605227A/en
Pending legal-status Critical Current

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Abstract

The invention discloses a hollow capsule with a health-care function. The hollow capsule is prepared from components in parts by mass as follows: 5-10 parts of a ginseng extract, 3-12 parts of agaric, 2-10 parts of cordyceps, 4-10 parts of dodder seeds, 5-10 parts of kudzuvine roots, 5-10 parts of onion, 3-10 parts of ganoderma lucidum spore powder, 3-10 parts of Asiatic pennywort herbs, 2-6 parts of lentinus edodes mycelia polysaccharides, 5-15 parts of gelatin, 10-18 parts of HPMC (hydroxypropyl methyl cellulose), 10-19 parts of carrageenan, 7-18 parts of alginate, 7-18 parts of guar gum, 6-12 parts of seaweed polysaccharides, 1-3 parts of carboxymethyl glucomannan, 5-8 parts of PDMS (polydimethylsiloxane), 2-5 parts of triethyl citrate, 1-4 parts of glycerol, 0.1-0.5 parts of ethylparaben, 2-5 parts of methyl paraben, 0.2-0.6 parts of methyl silicone oil and 70-100 parts of purified water. The hollow capsule has the health-care function.

Description

A kind of Capsules with health care
Technical field
The present invention relates to the technical field of health food, particularly a kind of Capsules with health care.
Background technology
With the medicine of capsule dress, be all generally to esophagus and gastric mucosa powder excitatory or particle, or mouthfeel bad, be easy to volatilization, easily decomposed by saliva in the oral cavity, and easily suck the medicine of tracheae.These medicines incapsulate, and have both protected the medicine property of medicine and have not been destroyed, also protected digestive organs and respiratory tract.Removing capsule shells may cause drug wastage, drug waste, drug effect to reduce.In addition, some medicine needs solution absorption in intestines, and capsule is a kind of protection, and protection medicine is not by stomach acids destroy.
Capsules, at the bladder pharmaceutically referring to make with extraordinary filmogen (as gelatin, cellulose, polysaccharide etc.), according to dosage loads content (as powdery, liquid various kinds of drug etc.) wherein, is convenient to swallow.Existing Capsules just plays the effect of protection medicine mostly, and itself is without any health-care effect, is therefore necessary to propose a kind of Capsules with health care, can play protection medicine and not be damaged, have good health care simultaneously.
Summary of the invention
Object of the present invention solves the problems of the prior art exactly, and propose a kind of Capsules with health care, the medicine in the Capsules that can not only make is not damaged, and has good health care simultaneously.
For achieving the above object, the technical solution used in the present invention is:
A kind of Capsules with health care, the described Capsules with health care is obtained by the component of following mass parts: ginseng extract: 5 ~ 10 parts, auricularia auriculajudae: 3 ~ 12 parts, Chinese caterpillar fungus: 2 ~ 10 parts, the seed of Chinese dodder: 4 ~ 10 parts, the root of kudzu vine: 5 ~ 10 parts, onion: 5 ~ 10 parts, lucidum spore powder: 3 ~ 10 parts, centella: 3 ~ 10 parts, Lentinan: 2 ~ 6 parts, gelatin: 5 ~ 15 parts, hydroxypropyl methylcellulose: 10 ~ 18 parts, carragheen: 10 ~ 19 parts, alginate: 7 ~ 18 parts, guar gum: 7 ~ 18 parts, algal polysaccharides: 6 ~ 12 parts, Carboxyl Methyl Glucomannan: 1 ~ 3 part, dimethyl silicone polymer: 5 ~ 8 parts, triethyl citrate: 2 ~ 5 parts, glycerine: 1 ~ 4 part, ethyl hydroxy benzoate: 0.1 ~ 0.5 part, methyl p-hydroxybenzoate: 2 ~ 5 parts, methyl-silicone oil: 0.2 ~ 0.6 part, purified water: 70 ~ 100 parts.
In said components, auricularia auriculajudae, Chinese caterpillar fungus, the seed of Chinese dodder, the root of kudzu vine, onion, lucidum spore powder, centella, Lentinan, algal polysaccharides, Carboxyl Methyl Glucomannan are commercially available dry product, generally dry product are ground to 150 object material powders for subsequent use.
As preferably, described alginate is ultra-low viscosity potassium alginate, and the viscosity of ultra-low viscosity potassium alginate is 40-60cps.
Described carragheen preferably adopts the quick carragheen of potassium.
Described ginseng extract prepares according to following extraction process: dry gen-seng haulms is raw material, obtain Ginseng Root Powder after crushed, be that solvent extracts with water, Ginseng Root Powder, the mass ratio of water is 1:10, be heated to boiling extraction 3 times, each extraction 2 hours, extract is merged after filtration, adsorb through macroporous resin column, wash assorted with water wash, use ethanol again, the mixed solvent wash-out of water volume ratio 2:3, collect and merge eluent, reclaim ethanol extremely without alcohol, continue concentration and evaporation water to proportion d=1.15, spraying dry, pulverized 100 mesh sieves, obtained described ginseng extract.
Described ginseng extract comprises panaxan, ginseng polypeptide and gen-seng haulms polysaccharide, ginseng polypeptide can obviously reduce blood sugar and hepatic glycogen content, gen-seng haulms polysaccharide can obviously to the hypertension of antiadrenergic drug and alloxan, panaxan, ginseng polypeptide can reduce euglycemia and hepatic glycogen, all there is inhibitory action to the hyperglycaemia that adrenaline, alloxan and glucose cause simultaneously, and the decomposition of adrenaline to hepatic glycogen can be strengthened.
As preferably, described Chinese caterpillar fungus adopts ultralow temperature multiple sterilizations technology, and the cordyceps product of ultrasonic wave Rapid Cleaning, guarantees that Cordyceps sinensis raw material reaches safe edible grade standard, guarantee that the active component of Cordyceps sinensis is not destroyed, cordycep includes cordycepic acid, vitamin B12, fat, albumen etc. simultaneously.Chinese caterpillar fungus property is sweet, Wen Ping, nontoxic, it is famous strengthening by means of tonics medicine, conventional meat boiled dinner, there is the effect that qi-restoratives is healthy and strong, be applicable to treat Lung Qi deficiency and deficiency of both the lung and kidney, pulmonary tuberculosis etc. caused spitting of blood or blood-stained sputum, cough, breathe hard, night sweat etc., also good curative effect is had, the excellent tonic product of the person that is also oldaged physically weak to impotence due to deficiency of the kidney, waist knee ache etc.
As preferably, the described seed of Chinese dodder adopts the seed of Chinese dodder fried, the seed of Chinese dodder aches for the waist knee muscles and bones of kidney deficiency and liver, legs and feet are weak and feeble, impotence and seminal emission, crazy talk, frequent urination, dripping urination, dizzy, the disease tool such as blurring of vision, Hiccough and deaf and women is with down, habitual abortion improve significantly function, generally be listed in top grade, clothes of a specified duration have improving eyesight and make light of one's life by commiting suicide and prolong life, the nutritional labeling in the seed of Chinese dodder fried can better absorb by human body.
Described lucidum spore powder preferably adopts sporoderm-broken rate to be greater than the lucidum spore powder of 99%, and can direct market purchase obtain, lucidum spore powder can strengthen immune function, prevention and therapy tumour and cancer; Reduce blood pressure, prevent the generation of cardiovascular epidemic disease; Stimulate the secretion of insulin, reduce blood sugar concentration; Accelerate blood microcirculation, improve blood oxygen ability, reduce the invalid oxygen demand under body inactive state, eliminate interior free yl, improve the closed stratum of body cell film, anti-radiation, improve liver, marrow, blood synthetic DNA, RNA, protein ability, sporoderm-broken rate be greater than 99% lucidum spore powder can directly absorb by human body intestinal canal, health-care effect is obvious.
As preferably, the described Capsules with health care is obtained by the component of following mass parts: ginseng extract: 5 parts, auricularia auriculajudae: 3 parts, Chinese caterpillar fungus: 2 parts, the seed of Chinese dodder: 4 parts, the root of kudzu vine: 5 parts, onion: 5 parts, lucidum spore powder: 3 parts, centella: 3 parts, Lentinan: 2 parts, gelatin: 5 parts, hydroxypropyl methylcellulose: 10 parts, carragheen: 10 parts, alginate: 7 parts, guar gum: 7 parts, algal polysaccharides: 6 parts, Carboxyl Methyl Glucomannan: 1 part, dimethyl silicone polymer: 5 parts, triethyl: 2 parts, glycerine: 1 part, ethyl hydroxy benzoate: 0.1 part, methyl p-hydroxybenzoate: 2 parts, methyl-silicone oil: 0.2 part, purified water: 70 parts.
As preferably, the described Capsules with health care is obtained by the component of following mass parts: ginseng extract: 10 parts, auricularia auriculajudae: 12 parts, Chinese caterpillar fungus: 10 parts, the seed of Chinese dodder: 10 parts, the root of kudzu vine: 10 parts, onion: 10 parts, lucidum spore powder: 10 parts, centella: 10 parts, Lentinan: 6 parts, gelatin: 15 parts, hydroxypropyl methylcellulose: 18 parts, carragheen: 19 parts, alginate: 18 parts, guar gum: 18 parts, algal polysaccharides: 12 parts, Carboxyl Methyl Glucomannan: 3 parts, dimethyl silicone polymer: 8 parts, triethyl: 5 parts, glycerine: 4 parts, ethyl hydroxy benzoate: 0.5 part, methyl p-hydroxybenzoate: 5 parts, methyl-silicone oil: 0.6 part, purified water: 100 parts.
Purified water of the present invention is generally distilled water or deionized water.
Have the preparation method of the Capsules of health care described in the present invention also provides, described method is:
(1) capsule material glue is prepared: according to the formula of Capsules, get the raw material of prescription amount, gelatin, hydroxypropyl methylcellulose, carragheen and guar gum being put into purified water immersion makes it expand, other surplus stocks are added after gelatin, hydroxypropyl methylcellulose, carragheen and guar gum dissolve, be uniformly mixed, obtained capsule material glue;
(2) glue sheet: take out the capsule material glue that step (1) prepares, be evenly coated in smooth plate on the surface, be heated to 90 DEG C, evaporating surface moisture, obtained cushion compound, described cushion compound has certain toughness and flexible, and the thickness of cushion compound is generally 0.09 ~ 0.12mm.
(3) soft capsule is suppressed: during small lot batch manufacture, general with the manual compacting of pelleting mould; During production in enormous quantities, the normal automatic rotation rolling capsule machine that adopts is produced.
This well known to a person skilled in the art capsules preparation technique.
Beneficial effect of the present invention: the present invention by adding onion, auricularia auriculajudae, the root of kudzu vine in capsule housing; onion, auricularia auriculajudae, the root of kudzu vine all have the protective effect to cardiovascular and cerebrovascular; effectively can reduce cholesterol; coronary blood flow is increased; improve ischemic myocardium; reduce MCO, the effect such as platelet aggregation-against, anti-freezing.Ginseng polypeptide can obviously reduce blood sugar and hepatic glycogen content, gen-seng haulms polysaccharide can obviously to the hypertension of antiadrenergic drug and alloxan, panaxan, ginseng polypeptide can reduce euglycemia and hepatic glycogen, all there is inhibitory action to the hyperglycaemia that adrenaline, alloxan and glucose cause simultaneously, and the decomposition of adrenaline to hepatic glycogen can be strengthened; Cordycep includes cordycepic acid, vitamin B12, fat, albumen etc.Chinese caterpillar fungus property is sweet, Wen Ping, nontoxic, it is famous strengthening by means of tonics medicine, conventional meat boiled dinner, there is the effect that qi-restoratives is healthy and strong, be applicable to treat Lung Qi deficiency and deficiency of both the lung and kidney, pulmonary tuberculosis etc. caused spitting of blood or blood-stained sputum, cough, breathe hard, night sweat etc., also good curative effect is had, the excellent tonic product of the person that is also oldaged physically weak to impotence due to deficiency of the kidney, waist knee ache etc.; The seed of Chinese dodder aches for the waist knee muscles and bones of kidney deficiency and liver, legs and feet are weak and feeble, impotence and seminal emission, crazy talk, frequent urination, dripping urination, dizzy, the disease tool such as blurring of vision, Hiccough and deaf and women is with down, habitual abortion improve significantly function, generally be listed in top grade, clothes of a specified duration have improving eyesight and make light of one's life by commiting suicide and prolong life, the nutritional labeling in the seed of Chinese dodder fried can better absorb by human body; Lucidum spore powder can strengthen immune function, prevention and therapy tumour and cancer; Reduce blood pressure, prevent the generation of cardiovascular epidemic disease; Stimulate the secretion of insulin, reduce blood sugar concentration; Accelerate blood microcirculation, improve blood oxygen ability, reduce the invalid oxygen demand under body inactive state, eliminate interior free yl, improve the closed stratum of body cell film, anti-radiation, improve liver, marrow, blood synthetic DNA, RNA, protein ability, sporoderm-broken rate be greater than 99% lucidum spore powder can directly absorb by human body intestinal canal, health-care effect is obvious.Above-mentioned composition is added in capsule housing and makes capsule shape, make this health-care good product not by the restriction of time, place, raw material, making.
Detailed description of the invention
With specific embodiment, technical scheme of the present invention is described further below, but the protection content of this method is not limited thereto.
In the embodiment of the present invention, alginate is the ultra-low viscosity potassium alginate of viscosity 40-60cps, carragheen adopts the quick carragheen of potassium, Chinese caterpillar fungus is for adopting ultralow temperature multiple sterilizations technology, the cordyceps product of ultrasonic wave Rapid Cleaning, the seed of Chinese dodder adopts the seed of Chinese dodder fried, and lucidum spore powder is the lucidum spore powder that sporoderm-broken rate is greater than 99%, all obtains in market purchasing.
Ginseng extract prepares according to following extraction process: dry gen-seng haulms is raw material, obtain Ginseng Root Powder after crushed, 50g Ginseng Root Powder and the tinning of 500g water, be heated to boiling extraction 3 times, each extraction 2 hours, extract is merged after filtration, through macroporous resin column absorption, wash with water wash assorted, then use the mixed solvent wash-out of ethanol, water volume ratio 2:3, collect and merge eluent, reclaim ethanol to without alcohol, continue concentration and evaporation water to proportion d=1.15, spraying dry, pulverized 100 mesh sieves, obtained ginseng extract 6.3g.
Embodiment one:
A kind of Capsules with health care, obtained by following component: ginseng extract: 5g, auricularia auriculajudae: 3g, Chinese caterpillar fungus: 2g, the seed of Chinese dodder: 4g, the root of kudzu vine: 5g, onion: 5g, lucidum spore powder: 3g, centella: 3g, Lentinan: 2g, gelatin: 5g, hydroxypropyl methylcellulose: 10g, carragheen: 10g, alginate: 7g, guar gum: 7g, algal polysaccharides: 6g, Carboxyl Methyl Glucomannan: 1g, dimethyl silicone polymer: 5g, triethyl: 2g, glycerine: 1g, ethyl hydroxy benzoate: 0.1g, methyl p-hydroxybenzoate: 2g, methyl-silicone oil: 0.2g, distilled water: 70g.
Described Capsules obtains by following preparation method:
(1) capsule material glue is prepared: measure each raw material according to above-mentioned formula, gelatin, hydroxypropyl methylcellulose, carragheen and guar gum being put into distilled water immersion makes it expand, other surplus stocks are added after gelatin, hydroxypropyl methylcellulose, carragheen and guar gum dissolve, be uniformly mixed, obtained capsule material glue;
(2) glue sheet: take out the capsule material glue that step (1) prepares, be evenly coated in smooth plate on the surface, be heated to 90 DEG C, evaporating surface moisture, obtained cushion compound, described cushion compound has certain toughness and flexible, and the thickness of cushion compound is 0.1mm.
(3) soft capsule is suppressed: with the manual compacting of pelleting mould, prepare the Capsules with health care.
Embodiment two:
A kind of Capsules with health care, obtained by following component: ginseng extract: 10g, auricularia auriculajudae: 12g, Chinese caterpillar fungus: 10g, the seed of Chinese dodder: 10g, the root of kudzu vine: 10g, onion: 10g, lucidum spore powder: 10g, centella: 10g, Lentinan: 6g, gelatin: 15g, hydroxypropyl methylcellulose: 18g, carragheen: 19g, alginate: 18g, guar gum: 18g, algal polysaccharides: 12g, Carboxyl Methyl Glucomannan: 3g, dimethyl silicone polymer: 8g, triethyl: 5g, glycerine: 4g, ethyl hydroxy benzoate: 0.5g, methyl p-hydroxybenzoate: 5g, methyl-silicone oil: 0.6g, distilled water: 100g.
Preparation method is with embodiment one.

Claims (9)

1. one kind has the Capsules of health care, the described Capsules with health care is obtained by the component of following mass parts: ginseng extract: 5 ~ 10 parts, auricularia auriculajudae: 3 ~ 12 parts, Chinese caterpillar fungus: 2 ~ 10 parts, the seed of Chinese dodder: 4 ~ 10 parts, the root of kudzu vine: 5 ~ 10 parts, onion: 5 ~ 10 parts, lucidum spore powder: 3 ~ 10 parts, centella: 3 ~ 10 parts, Lentinan: 2 ~ 6 parts, gelatin: 5 ~ 15 parts, hydroxypropyl methylcellulose: 10 ~ 18 parts, carragheen: 10 ~ 19 parts, alginate: 7 ~ 18 parts, guar gum: 7 ~ 18 parts, algal polysaccharides: 6 ~ 12 parts, Carboxyl Methyl Glucomannan: 1 ~ 3 part, dimethyl silicone polymer: 5 ~ 8 parts, triethyl citrate: 2 ~ 5 parts, glycerine: 1 ~ 4 part, ethyl hydroxy benzoate: 0.1 ~ 0.5 part, methyl p-hydroxybenzoate: 2 ~ 5 parts, methyl-silicone oil: 0.2 ~ 0.6 part, purified water: 70 ~ 100 parts.
2. Capsules as claimed in claim 1, it is characterized in that described alginate is ultra-low viscosity potassium alginate, the viscosity of described ultra-low viscosity potassium alginate is 40-60cps.
3. Capsules as claimed in claim 1, is characterized in that described carragheen is the quick carragheen of potassium.
4. Capsules as claimed in claim 1, it is characterized in that described ginseng extract prepares according to following extraction process: dry gen-seng haulms is raw material, obtain Ginseng Root Powder after crushed, be that solvent extracts with water, Ginseng Root Powder, the mass ratio of water is 1:10, be heated to boiling extraction 3 times, each extraction 2 hours, extract is merged after filtration, adsorb through macroporous resin column, wash assorted with water wash, use ethanol again, the mixed solvent wash-out of water volume ratio 2:3, collect and merge eluent, reclaim ethanol extremely without alcohol, continue concentration and evaporation water to proportion d=1.15, spraying dry, pulverized 100 mesh sieves, obtained described ginseng extract.
5. Capsules as claimed in claim 1, is characterized in that described Chinese caterpillar fungus adopts ultralow temperature multiple sterilizations technology, the cordyceps product of ultrasonic wave Rapid Cleaning.
6. Capsules as claimed in claim 1, is characterized in that the described seed of Chinese dodder adopts the seed of Chinese dodder fried.
7. Capsules as claimed in claim 1, is characterized in that described lucidum spore powder is the lucidum spore powder that sporoderm-broken rate is greater than 99%.
8. Capsules as claimed in claim 1, it is characterized in that described Capsules is obtained by the component of following mass parts: ginseng extract: 5 parts, auricularia auriculajudae: 3 parts, Chinese caterpillar fungus: 2 parts, the seed of Chinese dodder: 4 parts, the root of kudzu vine: 5 parts, onion: 5 parts, lucidum spore powder: 3 parts, centella: 3 parts, Lentinan: 2 parts, gelatin: 5 parts, hydroxypropyl methylcellulose: 10 parts, carragheen: 10 parts, alginate: 7 parts, guar gum: 7 parts, algal polysaccharides: 6 parts, Carboxyl Methyl Glucomannan: 1 part, dimethyl silicone polymer: 5 parts, triethyl: 2 parts, glycerine: 1 part, ethyl hydroxy benzoate: 0.1 part, methyl p-hydroxybenzoate: 2 parts, methyl-silicone oil: 0.2 part, purified water: 70 parts.
9. Capsules as claimed in claim 1, it is characterized in that described Capsules is obtained by the component of following mass parts: ginseng extract: 10 parts, auricularia auriculajudae: 12 parts, Chinese caterpillar fungus: 10 parts, the seed of Chinese dodder: 10 parts, the root of kudzu vine: 10 parts, onion: 10 parts, lucidum spore powder: 10 parts, centella: 10 parts, Lentinan: 6 parts, gelatin: 15 parts, hydroxypropyl methylcellulose: 18 parts, carragheen: 19 parts, alginate: 18 parts, guar gum: 18 parts, algal polysaccharides: 12 parts, Carboxyl Methyl Glucomannan: 3 parts, dimethyl silicone polymer: 8 parts, triethyl: 5 parts, glycerine: 4 parts, ethyl hydroxy benzoate: 0.5 part, methyl p-hydroxybenzoate: 5 parts, methyl-silicone oil: 0.6 part, purified water: 100 parts.
CN201510019468.XA 2015-01-14 2015-01-14 Hollow capsule with health-care function Pending CN104605227A (en)

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CN105853388A (en) * 2016-04-25 2016-08-17 夏放军 Health care hollow capsule and preparation method thereof
CN105919073A (en) * 2016-04-25 2016-09-07 孙继勇 Vacant plant capsules made from wall-breaking glossy ganoderma spore powder and making method of vacant plant capsules
CN112220885A (en) * 2020-11-18 2021-01-15 生升美高科技(武汉)有限责任公司 Traditional Chinese medicine composition for protecting gastric mucosa and preparation method and application thereof

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* Cited by examiner, † Cited by third party
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CN105853388A (en) * 2016-04-25 2016-08-17 夏放军 Health care hollow capsule and preparation method thereof
CN105919073A (en) * 2016-04-25 2016-09-07 孙继勇 Vacant plant capsules made from wall-breaking glossy ganoderma spore powder and making method of vacant plant capsules
CN112220885A (en) * 2020-11-18 2021-01-15 生升美高科技(武汉)有限责任公司 Traditional Chinese medicine composition for protecting gastric mucosa and preparation method and application thereof

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Application publication date: 20150513