CN101238871B - Balloonflower loquat honey tablet - Google Patents
Balloonflower loquat honey tablet Download PDFInfo
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- CN101238871B CN101238871B CN2007100562494A CN200710056249A CN101238871B CN 101238871 B CN101238871 B CN 101238871B CN 2007100562494 A CN2007100562494 A CN 2007100562494A CN 200710056249 A CN200710056249 A CN 200710056249A CN 101238871 B CN101238871 B CN 101238871B
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Abstract
The invention provides the functional food fresh ballonflower loquat sweet slice and the producing method thereof. The product uses fresh ballonflower and loquat as raw materials, and is produced by the processes of steaming, slicing, vacuum honey infiltration, and so on, which keep the original flavor of ballonflower and effective ingredients, and make it taste good while maintain the medical effects.
Description
Background of invention
Balloonflower root is China's traditional Chinese medicine, belongs to one of 40 kinds of large medicinal materials commonly used, food medicine dual-purpose.With a surname lung, relieve sore throat, eliminate the phlegm, effect such as apocenosis is widely used in the various prescriptions.Modern pharmacology shows that balloonflower root has multiple pharmacologically active:
1, anti-inflammatory activity
The anti-inflammatory activity of balloonflower root mainly is owing to wherein contain platycodin (Platycodins).Zoopery shows, gastric infusion, balloonflower root can resist rat paw edema due to carrageenan and the acetic acid; Oral administration can significantly suppress the formation that fat ball granulation expands.Platycodin can effectively suppress adjuvant and cause rat arthritis.Molecular biology research to inflammatory model due to the lipopolysaccharides shows that balloonflower root water extract anti-inflammatory mechanism is regulation and control NF-
KThe activity of the B factor and anti-inflammation gene are expressed.Zoopery confirms, Platycodin D and D
3Has anti-inflammatory activity.The mechanism of its anti-inflammatory activity is that it can regulate and control the early stage medium of inflammation, and as inflammatory model due to TPA, Platycodin D can suppress PGE
2Produce; To lipopolysaccharides (inflammatory model due to (LPS), Platycodin D and D
3Can suppress the secretion that NO produced and increased TNF-α.
The scholar who has studies show that 2, and " O-acetyl group polygalic acid D, platycodin A, Platycodin D and polygalic acid D can suppress iNOS and COX-2 to the anti-inflammatory activity of 7 kinds of platycodins.Electrophoretic mobility mutation analysis (EMSA) shows: platycodin is by stoping NF-to the inhibitory action of iNOS and COX-2
KThe activity of the B factor, minimizing iNOS and COX-2 gene expression realize.
Zoopery confirms that balloonflower root water extract (CK) can suppress APAP and CCl
4The mouse hepatotoxicity wind agitation that causes.Experiment in vitro studies show that this protective effect is because it can stop biologically active and the measured by esr technique of the APAP of P450 mediation.Balloonflower root water extract (CK) can also suppress acute CCl simultaneously
4The rat liver fibrosis degree that causes increases.To CCl
4The HSCs molecular biology research of poisoning rats'liver and in vitro culture shows: its mechanism of action is relevant with the activation that it can suppress the inflammation of liver and HSCs.Platycodin has protective effect to the mouse hepatic injury due to the tetrabutyl peroxide (t-BHP); interior animal experiment and external liver cell model experiment confirm; platycodin can obviously reduce the liver oxidative damage due to the tetrabutyl peroxide; remove 1; 1-diphenyl-2-trinitrophenyl-hydrazine (DPPH) and peroxide radical, and then confirmed that also platycodin has antioxidation.
2, eliminate the phlegm and antitussive activity
Balloonflower root has cough-relieving and the effect of reducing phlegm.Resolve phlegm effect comprises the generation that promotes saliva and bronchial secretion.Expectorant activity to monomer saponin studies show that, Platycodin D and D
3By atomized medicine introducing, can increase the release of mucoitin in the rat epithelial cell.Platycodin D
3Effect stronger than the effect of ATP and Ambroxole.Thereby Platycodin D and D
3All can be used as a kind of effective apophlegmatisant uses.
3, antitumor and immunoregulation effect
Platycodon root polysaccharide is different from other polysaccharide immunomodulators such as lentinan, schizophyllan.Can activate the generation with NO of transcribing of iNOS in macrophage, can increase polyclone IgM production of antibodies in the B cell, be the specific activator of macrophage and B cell.To studies show that of signal transduction process in membrane receptor and the cell: platycodon root polysaccharide can pass through TLR4/NF-
KB signal pipeline activating macrophage, thus induce the generation of NO and the mRNA of iNOS to express.By to studies show that of Toll-like receptor 4 (TI R4) signal pipeline, the macrophage activation effect is relevant with AP-1 (activator protein-1) with MAPKs (MAPK) due to the platycodon root polysaccharide.
The water extract of balloonflower root has antitumor and immunoregulation effect.These activity can realize by potential effect cell such as macrophage.To studies show that of mouse peritoneal macrophages, the balloonflower root water extract can pass through NF-
KThe trans transcriptional activation function of B raises the expression of iNOS and TNF-α, thereby causes the release of NO and TNF-α
[41]The balloonflower root water extract can also stimulate hyperplasia, deployment capabilities, phagocytosis, the cell inhibitory activity of macrophage to strengthen, and is a kind of potential macrophage function reinforcing agent.The balloonflower root water extract can cause the human lung cancer cell A549 of in vitro culture to grow suppressing and apoptosis, molecular biological studies show that, and the Apoptosis Mechanism that the balloonflower root water extract causes is relevant with the downward modulation of the reduction of telomerase activation and Bcl-2 expression.
4, promote the effect of the outer glandular secretion of pancreas
Zoopery, the Platycodin D of 10～100mg carries out rat oral gavage, can stimulation in rats pancreas exocrine gland secretion.Simultaneously, serum CCK (CCK) concentration increases.10mgkg
-1The Platycodin D of dosage can weaken the inhibitory action of the atropine of intravenous injection 300g (kgh) dosage to pancreatic secretion.10mgkg
-1The pancreatic secretion effect that produces of Platycodin D can be 50mgkg by dosage
-1Loxiglumide (a kind of cck receptor antagonist) suppress.Platycodin D stimulate the eccrine secretory mechanism of pancreas be cause gastrointestinal hormone particularly CCK discharge from duodenum, Platycodin D can promote the release of CCK, thereby some Chinese prescription preparations that contain balloonflower root can be used for pancreatitic treatment.
5, suppress pancreatic lipase activity and anti-obesity activity
Relative activity with pancreatic lipase is an index, and by the experiment in vitro method, confirming in each extract part of balloonflower root that only total saponins of platycodon grandiflorum demonstrates suppresses the pancreatic lipase activity.A kind of based on 1, the multistep colorimetric method of 2-diglyceride is used for external test pancreatic lipase activity, confirms that Platycodin D can suppress the pancreatic lipase activity in a kind of mode of competition.Experiment in vitro confirms that total saponins of platycodon grandiflorum and Platycodin D, platycodin A and platycodoside C all can suppress the pancreatic lipase activity in various degree.When feeding mouse with the high fat diet that contains the balloonflower root water extract, fat mass and control group more obviously descend around mouse body weight and the uterus.Thereby think that the anti-obesic action of balloonflower root may be because the platycodin constituents suppresses the pancreatic lipase activity, thereby suppress absorption to food fat.
6, hypolipidemic activity
Experiment confirm, platycodin can influence the lipid content in serum and the liver.Be fed with the feed of balloonflower root for hyperlipidemia rats model due to the high lipid food of feeding.Feed mass fraction and be the rat of 5% balloonflower root feed, in its serum and the liver lipid, the concentration of T-CHOL and triglyceride significantly is lower than control group.To studies show that of total saponins of platycodon grandiflorum effect for reducing blood fat, the total saponins of platycodon grandiflorum of various dose is comparatively remarkable to the reduction difference between the effects of rat high fat of blood.Heavy dose of [200mg (kgd)
-1] can conspicuousness ground reduce TC (T-CHOL), LDI-C (low-density ester gp cholesterol), the HDL-C (high density ester gp cholesterol) of hyperlipidemia rats, its effect degree surpasses positive drug group (gynostemma pentaphylla); Small dose group and middle dosage group are only influential to the part index number of blood fat.
7, improve the insulin resistance effect of diabetes
On adult-onset diabetes complication model-diabetes obesity and modest Zucker mouse, studied balloonflower root to improving the effect of diabetic complication and lipid.Take balloonflower root after 4 weeks, the content of modest and fat Zucker mouse serum levels of triglyceride obviously reduces.In oral glucose tolerance test, balloonflower root can obviously reduce fat Zucker mouse serum triglyceride and serum insulin content, and glucose content significantly reduces during 30min behind clothes, and its former glucose transporter-4-protein content has increase trend.Result of study shows that for being the metabolic disorder patient of feature such as adult-onset diabetes complication, X syndrome and coronary heart disease etc. with the hyperinsulinemia, balloonflower root can stop and improve these symptoms effectively.
8, other biological activity
Balloonflower root has analgesic activity: in the tail-flick method experiment.The painful effect in town during the intraventricular injection Platycodin D is proportionate with dosage, and the painful effect in the town of its generation continues 1h at least.Further result of study shows, the painful effect in the town that Platycodin D produces and supraspinal GABA (A), GA-BA (B) (GABA), NMDA and non-NMDA (N-methyl D-asparatate) are receptor related.The painful effect in its town is because stimulation has weakened norepinephrine and serotonin path, and is irrelevant with the morphine path.Discover that further when the Platycodin D ventricles of the brain or film inner injecting and administering, at whipping, turn round and all shown the painful effect in strong town in the experiment of dissimilar pain models such as body and formalin, it acts on mainly in central nervous system, not influenced by opiate receptors.The antiviral activity of balloonflower root etc.: anti-RSV (Respiratory Syncytial Virus(RSV)) activity:, detected the anti-RSV activity of 44 kinds of Chinese medicines with cell pathology effect analysis (CPE).27 kinds of Chinese medicines that comprise balloonflower root have shown effectively or the anti-RSV activity that relaxes Radix Platycodonis extract half-inhibition concentration (IC
50) value is 6.3～52.1mgmL
-1, studies show that further platycodin is its active component.Activity research to balloonflower root shows that also it has: its extracting in boiling water thing has insecticidal activity, antimutagenic activity, antioxidation activity and restraint of tyrosinase activity preferably.
The invention summary
The present invention is a kind of balloonflower root goods, and directly edible bright balloonflower root honey sheet of a kind of people of being suitable for and preparation method thereof specifically is provided.
At present, as the salted vegetables, other products are rare except traditionally for the balloonflower root goods, and in the manufacturing process in order to remove bitter taste, float through water repeatedly, the platycodin composition that embodies bitter taste also runs off thereupon.The report of the article of balloonflower root dried meat was also once arranged, but do not see its launch, all through candy or sweet boiling, loss of effective components is big for its technology, and some active ingredients of honey are destroyed when using honey, and the technology relative complex, is not easy to operation.
The purpose of this invention is to provide the strong sweet sheet preparation method of a kind of simple possible, can keep having kept to greatest extent under the good condition of mouthfeel active ingredients such as platycodin, the medicinal efficacy of balloonflower root is brought into play to a certain extent, demonstrated fully the characteristics of integration of drinking and medicinal herbs.
Innovative point of the present invention is to utilize balloonflower root on the basis of traditional Chinese medicine eliminating phlegm and relieving cough effect, is aided with loquat honey, because in the place that produces loquat honey, the locals uses loquat honey to treat various coughs, its effect is remarkable.The experiment and the result of balloonflower loquat honey tablet are as follows:
[experiment material]
Sample: total saponin(e and balloonflower loquat honey tablet extract
Animal: Kunming mouse, 18～22g.Male and female half and half are available from grinding animal housing in the Jilin Province.
Reagent: absolute ethyl alcohol (AR), 0.25% phenol red solution, 5%NaHCO3 solution.
[method and result]
One, phlegm-dispelling functions
Get 30 of mouse and be divided into three groups at random, first group is the normal control group, second group is total saponins of platycodon grandiflorum 250mg/kg group, the 3rd group is balloonflower loquat honey tablet extract 250mg/kg group, irritating stomach is subjected to reagent thing (0.2ml/10g) after 30 minutes, lumbar injection 0.25% phenol red solution 0.5ml/ only, after 30 minutes, put to death mouse, isolate tracheae, use 5%NaHCO3 solution lavation respiratory tract three times, each 0.5ml, the accurate washing lotion 1ml that draws, quantitatively add absolute ethyl alcohol 2ml, shake up, (3000r/min * 2min) supernatant is measured its trap in 721 type spectrophotometer 558nm places in centrifugation.Try to achieve the phenol red content of excretion according to phenol red calibration curve.Result's (seeing Table 3-1) control group is 0.957 ± 0.377 (ug/ml), and the total saponins of platycodon grandiflorum group is 3.10 ± 1.417 (p＜0.001), and balloonflower loquat honey tablet is 3.533 ± 1.330.Experimental result shows that total saponins of platycodon grandiflorum has significant phlegm-dispelling functions, and the phlegm-dispelling functions of balloonflower loquat honey tablet is more obvious.
The phlegm-dispelling functions of table 1 platycodin and balloonflower loquat honey tablet
Annotate: n=10, X ± SD,
*P＜0.001
Two, antitussive effect
Get 30 random packet of mouse, the grouping administration is the same.1h puts into spray tank (every group) with mouse after the administration, sprays into the concentrated ammonia liquor aerosol and stops after 30 seconds, opens tabula, the time (draw cough incubation period) of record mouse from contact ammonia mist to the appearance cough first time.Result's (seeing Fig. 1-1) control group was 37.92 ± 3.44 (seconds), and the total saponins of platycodon grandiflorum group is 92.92 ± 9.36 (p＜0.001), and balloonflower root balloonflower loquat honey tablet group is 99.50 ± 10.77 (p＜0.001).Experimental result shows that total saponins of platycodon grandiflorum and balloonflower loquat honey tablet all have significant antitussive effect, and balloonflower loquat honey tablet is a little more than total saponin(e.
Invention realization approach
The present invention is achieved in that
With fresh balloonflower root and loquat honey is raw material, with balloonflower root through scrub, steam, section, electrolyte treatment, vacuum ooze series of process such as honey, oven dry, packing and make balloonflower loquat honey tablet.This technology one big characteristics are that the training of balloonflower root raw material steams, and have kept the minimum loss of active ingredient like this, can keep the distinctive taste of balloonflower root itself to greatest extent again, and equipment is not had strict demand, and general steamer gets final product.Calcium chloride and citric acid that we adopt are electrolyte, and calcium ion can form gel with the pectin in the balloonflower root, has increased the plumpness of product, and citric acid also helps the formation of gel.After the electrolyte treatment, significantly increased the toughness of sweet sheet, technological operation after being easy to, guarantor's type is effective.Increased the tart flavour mouthfeel of sweet sheet itself so on the one hand, on the other hand,, added calcareous again from the nutrition angle.Meanwhile, we have added cycloheptaamylose again in the electrolyte immersion process, have so just covered the fat-soluble material that is bitter taste in the balloonflower root.This technology adopts vacuum to ooze honey in oozing sweet process, honey is seethed with excitement at a lower temperature, and can extract the air in the balloonflower root tissue out, quicken to ooze sweet speed and kept not only honey some easy ruined nutritional labelings but also honey is recycled under the too high condition of temperature simultaneously.Ooze honey time weak point like this, effective.The present invention adopts vacuum packaging, can prevent brown stain under the condition without sodium hydrogensulfite, never degenerates without long preservation under the situation of anticorrisive agent.
This method changes a little, just goes for dried balloonflower root, and is the same on outward appearance and the interior quality.
By the balloonflower loquat honey tablet of this explained hereafter, the pure orange colour that is of color, vivid transparent, the quality softness, fresh and sweet and slightly bitter.
The smell of balloonflower root own is strong, and cost is low, steady quality, and period of storage is long.
In conjunction with production practices, balloonflower loquat honey tablet and preparation method thereof is done to describe in detail.
Selecting for use of raw and auxiliary material:
1, bright balloonflower root is selected 3 years living balloonflower root for use, selects diameter more than 1 centimetre, and the less balloonflower root of branch is raw material.
2, honey is selected loquat honey for use, should be to process from strand, and is convenient to operation.
Manufacture craft:
1, scrubs a large amount of washing and join the machine washing brush, get final product with hairbrush on a small quantity with the high-pressure water jet formula.Clean earth is removed in requirement, tissue and sick scar addle.
2, steam according to the size of balloonflower root raw material and adjust steaming time, the general steaming gets final product thoroughly.
3, manual peeling is adopted in peeling
4, section is cut into slices with disk rotor formula slicer.Can cut into slices by hand on a small quantity.Oblique sheet is cut in requirement, thickness 2.5-3 millimeter.Thickness is even, and appearance does not rupture.
5, electrolyte-impregnated adopts certain density calcium chloride and citric acid solution to soak 2 hours.
6, vacuum is oozed honey and will be soaked good balloonflower root sheet and put into through finished loquat honey 1 hour, reduced vacuum, heating, and temperature reaches 50 ℃, and vacuum is 0.08-0.09Mpa, when sweet concentration is that 70-72 gets final product when spending.
7, oven dry is soaked and was put into drying chamber or baking oven 50-60 ℃ of baking behind the honey 8-10 hour.
8, sterilization
9, packing vinyon packaging bag vacuum packaging.
The balloonflower loquat honey tablet water content that this example makes is at 10-12%, total reducing sugar 54-55%, total saponin(e 1.2-1.5%, 2 years shelf-lifves.
Description of drawings
Fig. 1 is total saponins of platycodon grandiflorum and balloonflower loquat honey tablet antitussive effect comparison diagram.
Fig. 2 is the balloonflower loquat honey tablet pictorial diagram.
Claims (3)
1. one kind is the balloonflower root honey sheet of raw material with bright balloonflower root and loquat honey, it is characterized in that selecting for use life in 3 years, diameter more than 1 centimetre, the less balloonflower root of branch is the oblique sheet of cutting 2.5-3 millimeter thickness after raw material steams, calcium chloride and citric acid solution that employing has added cycloheptaamylose soaked 2 hours, to soak good balloonflower root sheet and put into honey after 1 hour, heating, decompression, be that 50 ℃, vacuum are that 0.08-0.09Mpa, sweet concentration are that 70-72 oozes the honey success when spending to temperature, put in drying chamber or the baking oven 50-60 ℃ of baking 8-10 hour, promptly get the sweet sheet of balloonflower root Chinese lute.
2. balloonflower root honey sheet according to claim 1 is characterized in that honey should be the loquat honey that processes from strand.
3. balloonflower root honey sheet according to claim 1 is characterized in that water content at 10-12%, total reducing sugar 54-55%, and total saponin(e 1.2-1.5%, 2 years shelf-lifves, and adopt transparent polyethylene packaging bag vacuum packaging.
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| CN2007100562494A CN101238871B (en) | 2007-10-29 | 2007-10-29 | Balloonflower loquat honey tablet |
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| CN2007100562494A CN101238871B (en) | 2007-10-29 | 2007-10-29 | Balloonflower loquat honey tablet |
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| CN101238871B true CN101238871B (en) | 2011-08-17 |
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Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103039685A (en) * | 2013-01-04 | 2013-04-17 | 山东大学（威海） | Method for processing preserved platycodon grandiflorum |
| CN103583766A (en) * | 2013-10-31 | 2014-02-19 | 巫溪县瑞雪药材种植有限责任公司 | Making method for preserved platycodon grandiflorum fruit |
| CN104770735A (en) * | 2014-01-10 | 2015-07-15 | 山东大学（威海） | Processing method of panax quinquefolius radix ginseng rubra sliced honey slices |
| CN104770714A (en) * | 2014-01-11 | 2015-07-15 | 山东大学（威海） | Processing method of panax quinquefolius honey slices |
| CN105249335A (en) * | 2015-11-03 | 2016-01-20 | 界首市联发种植专业合作社 | Processing method of instant platycodon grandiflorum strips |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1988813A (en) * | 2005-04-22 | 2007-06-27 | 株式会社长生道拉吉 | Manufacturing method of old red platycodon, old red platycodon therefrom and functional food containing the same |
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2007
- 2007-10-29 CN CN2007100562494A patent/CN101238871B/en not_active Expired - Fee Related
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1988813A (en) * | 2005-04-22 | 2007-06-27 | 株式会社长生道拉吉 | Manufacturing method of old red platycodon, old red platycodon therefrom and functional food containing the same |
Non-Patent Citations (3)
| Title |
|---|
| 王敏.山楂果脯加工新工艺.农村百事通.2000,(2000年17期),40. * |
| 贾生平.桔梗的加工技术.上海蔬菜.2005,(2005(1)),76-77. * |
| 邹圣冬等.低糖胡萝卜脯的保藏性研究.食品研究与开发.2006,27((5)),141,134. * |
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