CN104173317A - Gelatin hollow capsule - Google Patents
Gelatin hollow capsule Download PDFInfo
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- CN104173317A CN104173317A CN201410364814.3A CN201410364814A CN104173317A CN 104173317 A CN104173317 A CN 104173317A CN 201410364814 A CN201410364814 A CN 201410364814A CN 104173317 A CN104173317 A CN 104173317A
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Abstract
The invention discloses a gelatin hollow capsule which comprises the following components in parts by mass: 20 to 30 parts of bone gelatin obtained by virtue of an acid method, 20 to 30 parts of bone gelatin obtained by virtue of an enzymatic method, 20 to 30 parts of polyacrylic resin, 2 to 6 parts of malt extract, 0.2 to 0.8 part of a nipagin preservative, 40 to 60 parts of ethyl alcohol, 5 to 13 parts of carrageenan, 2 to 5 parts of triethyl phosphate, 1 to 4 parts of glycerin, 0.5 to 1 part of titanium dioxide powder, 1 to 3 parts of magnesium stearate, 0.1 to 0.3 part of ethylparaben, 2 to 5 parts of methyl 4-hydroxybenzoate, 0.2 to 0.6 part of methyl silicone oil, 1 to 3 parts of food colourants and 40 to 70 parts of purified water. Based on the technical scheme disclosed by the invention, the quality of the gelatin hollow capsule is improved, and the production cycle of gelatin is shortened at the same time, so that a production process is greatly improved.
Description
[technical field]
The present invention relates to the technical field, particularly a kind of technical field of gelatin Capsules of Capsules formula.
[background technology]
With the medicine of capsule dress, be all generally to esophagus and gastric mucosa powder excitatory or granule, or mouthfeel bad, be easy to volatilization, in oral cavity, easily by saliva, decomposed, and the medicine that easily sucks trachea.These medicines incapsulate, and have both protected the medicine property of medicine not to be destroyed, and have also protected digestive organs and respiratory tract.Removing capsule shells may cause drug wastage, drug waste, drug effect to reduce.In addition, some medicine need to be at enteral solution absorption, and capsule is a kind of protection, and protection medicine is not by stomach acids destroy.Capsules is at the bladder that pharmaceutically refers to make with extraordinary filmogen (as gelatin, cellulose, polysaccharide etc.), content (as powdery, liquid various kinds of drug etc.) or according to dosage pack into wherein, is convenient to swallow.Traditional gelatine capsule inferior quality, the production cycle is longer.
[summary of the invention]
Object of the present invention solves the problems of the prior art exactly, a kind of gelatin Capsules is proposed, by adopting the mixing gelatin being formed by acid system bone gelatin and enzyme process bone gelatin, and strictly control acid system bone gelatin and enzyme process bone gelatin production technology, not only improved the quality of gelatin Capsules, also greatly shorten the production cycle of gelatin simultaneously, improved greatly production technology.
For achieving the above object, the present invention proposes a kind of gelatin Capsules, the mass ratio that comprises following component and each component is: acid system bone gelatin: 20～30 parts, enzyme process bone gelatin: 20～30 parts, polyacrylic resin: 20～30 parts, malt extract: 2～6 parts, parabens antiseptic: 0.2～0.8 part, ethanol: 40～60 parts, carrageenan: 5～13 parts, triethyl: 2～5 parts, glycerol: 1～4 part, titanium dioxide: 0.5～1 part, magnesium stearate: 1～3 part, ethyl hydroxybenzoate: 0.1～0.3 part, methyl parahydroxybenzoate: 2～5 parts, methyl-silicone oil: 0.2～0.6 part, food coloring: 1～3 part, purified water: 40～70 parts.
As preferably, in the hydrochloric acid that described acid system bone gelatin is 3.5～5% by the animal aggregate after defat in concentration, soak and make, the temperature of hydrochloric acid solution is controlled at 15～17 ℃, aggregate after pickling carries out the washing of 2～4 times, until the residual salt acid content in washing water lower than 0.1%, then proceeds to aggregate in the Muffle furnace of 600 ℃, burn and finally obtain finished product acid system bone gelatin.
As preferably, described enzyme process bone gelatin passes through proteasome degradation after being mixed with water by animal aggregate, after enzymolysis, use the pH value to 9.0 of limestone regulator solution, then heat mixed solution to 80～95 ℃, keep obtaining glue after 1h, glue is first gone out particle by cottonseed cake, then spent ion exchange resin removes soluble inorganic salt ion, and last glue is dried and is obtained finished product enzyme process bone gelatin by freezer dryer.
As preferably, the particle diameter of described animal aggregate is 3～12mm.
As preferably, described food coloring adopt natural from plant the direct one or any several mixture in Rhizoma Curcumae Longae, beta-carotene, chlorophyll and the Monas cuspurpureus Went of extraction.
As preferably, described parabens antiseptic is methyl hydroxybenzoate, ethyl hydroxybenzoate, propylparaben is the strongest and butoben mixes and forms.
As preferably, comprise that the mass ratio of following component and each component is: acid system bone gelatin: 20 parts, enzyme process bone gelatin: 20 parts, polyacrylic resin: 20 parts, malt extract: 2 parts, parabens antiseptic: 0.2 part, ethanol: 40 parts, carrageenan: 5 parts, triethyl: 2 parts, glycerol: 1 part, titanium dioxide: 0.5 part, magnesium stearate: 1 part, ethyl hydroxybenzoate: 0.1 part, methyl parahydroxybenzoate: 2 parts, methyl-silicone oil: 0.2 part, food coloring: 1 part, purified water: 40 parts.
As preferably, comprise that the mass ratio of following component and each component is: acid system bone gelatin: 25 parts, enzyme process bone gelatin: 25 parts, polyacrylic resin: 25 parts, malt extract: 4 parts, parabens antiseptic: 0.5 part, ethanol: 50 parts, carrageenan: 9 parts, triethyl: 3 parts, glycerol: 2 parts, titanium dioxide: 0.8 part, magnesium stearate: 1.5 parts, ethyl hydroxybenzoate: 0.2 part, methyl parahydroxybenzoate: 3.5 parts, methyl-silicone oil: 0.4 part, food coloring: 2 parts, purified water: 55 parts.
As preferably, comprise that the mass ratio of following component and each component is: acid system bone gelatin: 30 parts, enzyme process bone gelatin: 30 parts, polyacrylic resin: 30 parts, malt extract: 6 parts, parabens antiseptic: 0.8 part, ethanol: 60 parts, carrageenan: 13 parts, triethyl: 5 parts, glycerol: 4 parts, titanium dioxide: 1 part, magnesium stearate: 3 parts, ethyl hydroxybenzoate: 0.3 part, methyl parahydroxybenzoate: 5 parts, methyl-silicone oil: 0.6 part, food coloring: 3 parts, purified water: 70 parts.
Beneficial effect of the present invention: the animal aggregate that the present invention is 3～12mm by employing particle diameter is as raw material, shortened the process cycle of acid system and enzymatic treatment animal aggregate, improved production efficiency, acid system bone gelatin and enzyme process bone gelatin have good viscosity, freeze the physicochemical properties such as power and transparency, and strictly control acid system bone gelatin and enzyme process bone gelatin production technology, not only improved the quality of gelatin Capsules, also greatly shorten the production cycle of gelatin simultaneously, improved greatly production technology.
[specific embodiment]
A kind of gelatin Capsules of the present invention, the mass ratio that comprises following component and each component is: acid system bone gelatin: 20～30 parts, enzyme process bone gelatin: 20～30 parts, polyacrylic resin: 20～30 parts, malt extract: 2～6 parts, parabens antiseptic: 0.2～0.8 part, ethanol: 40～60 parts, carrageenan: 5～13 parts, triethyl: 2～5 parts, glycerol: 1～4 part, titanium dioxide: 0.5～1 part, magnesium stearate: 1～3 part, ethyl hydroxybenzoate: 0.1～0.3 part, methyl parahydroxybenzoate: 2～5 parts, methyl-silicone oil: 0.2～0.6 part, food coloring: 1～3 part, purified water: 40～70 parts, in the hydrochloric acid that described acid system bone gelatin is 3.5～5% by the animal aggregate after defat in concentration, soak and make, the temperature of hydrochloric acid solution is controlled at 15～17 ℃, aggregate after pickling carries out the washing of 2～4 times, until the residual salt acid content in washing water is lower than 0.1%, then aggregate is proceeded in the Muffle furnace of 600 ℃ and burn and finally obtain finished product acid system bone gelatin, described enzyme process bone gelatin passes through proteasome degradation after being mixed with water by animal aggregate, after enzymolysis, use the pH value to 9.0 of limestone regulator solution, then heat mixed solution to 80～95 ℃, keep obtaining glue after 1h, glue is first gone out particle by cottonseed cake, spent ion exchange resin is removed soluble inorganic salt ion again, last glue is dried and is obtained finished product enzyme process bone gelatin by freezer dryer, the particle diameter of described animal aggregate is 3～12mm, described food coloring adopts the natural Rhizoma Curcumae Longae of directly extracting from plant, beta-carotene, one or any several mixture in chlorophyll and Monas cuspurpureus Went, described parabens antiseptic is methyl hydroxybenzoate, ethyl hydroxybenzoate, the strongest and butoben of propylparaben mixes composition.
Embodiment mono-:
A kind of gelatin Capsules, the mass ratio that comprises following component and each component is: acid system bone gelatin: 20 parts, enzyme process bone gelatin: 20 parts, polyacrylic resin: 20 parts, malt extract: 2 parts, parabens antiseptic: 0.2 part, ethanol: 40 parts, carrageenan: 5 parts, triethyl: 2 parts, glycerol: 1 part, titanium dioxide: 0.5 part, magnesium stearate: 1 part, ethyl hydroxybenzoate: 0.1 part, methyl parahydroxybenzoate: 2 parts, methyl-silicone oil: 0.2 part, food coloring: 1 part, purified water: 40 parts, in the hydrochloric acid that described acid system bone gelatin is 5% by the animal aggregate after defat in concentration, soak and make, the temperature of hydrochloric acid solution is controlled at 15 ℃, aggregate after pickling carries out the washing of 4 times, until the residual salt acid content in washing water is lower than 0.1%, then aggregate is proceeded in the Muffle furnace of 600 ℃ and burn and finally obtain finished product acid system bone gelatin, described enzyme process bone gelatin passes through proteasome degradation after being mixed with water by animal aggregate, after enzymolysis, use the pH value to 9.0 of limestone regulator solution, then heat mixed solution to 85 ℃, keep obtaining glue after 1h, glue is first gone out particle by cottonseed cake, spent ion exchange resin is removed soluble inorganic salt ion again, last glue is dried and is obtained finished product enzyme process bone gelatin by freezer dryer, the particle diameter of described animal aggregate is 6mm, described food coloring adopts the natural Rhizoma Curcumae Longae of directly extracting from plant, beta-carotene, one or any several mixture in chlorophyll and Monas cuspurpureus Went, described parabens antiseptic is methyl hydroxybenzoate, ethyl hydroxybenzoate, the strongest and butoben of propylparaben mixes composition.
Embodiment bis-:
A kind of gelatin Capsules, the mass ratio that comprises following component and each component is: acid system bone gelatin: 25 parts, enzyme process bone gelatin: 25 parts, polyacrylic resin: 25 parts, malt extract: 4 parts, parabens antiseptic: 0.5 part, ethanol: 50 parts, carrageenan: 9 parts, triethyl: 3 parts, glycerol: 2 parts, titanium dioxide: 0.8 part, magnesium stearate: 1.5 parts, ethyl hydroxybenzoate: 0.2 part, methyl parahydroxybenzoate: 3.5 parts, methyl-silicone oil: 0.4 part, food coloring: 2 parts, purified water: 55 parts, in the hydrochloric acid that described acid system bone gelatin is 5% by the animal aggregate after defat in concentration, soak and make, the temperature of hydrochloric acid solution is controlled at 15 ℃, aggregate after pickling carries out the washing of 4 times, until the residual salt acid content in washing water is lower than 0.1%, then aggregate is proceeded in the Muffle furnace of 600 ℃ and burn and finally obtain finished product acid system bone gelatin, described enzyme process bone gelatin passes through proteasome degradation after being mixed with water by animal aggregate, after enzymolysis, use the pH value to 9.0 of limestone regulator solution, then heat mixed solution to 85 ℃, keep obtaining glue after 1h, glue is first gone out particle by cottonseed cake, spent ion exchange resin is removed soluble inorganic salt ion again, last glue is dried and is obtained finished product enzyme process bone gelatin by freezer dryer, the particle diameter of described animal aggregate is 6mm, described food coloring adopts the natural Rhizoma Curcumae Longae of directly extracting from plant, beta-carotene, one or any several mixture in chlorophyll and Monas cuspurpureus Went, described parabens antiseptic is methyl hydroxybenzoate, ethyl hydroxybenzoate, the strongest and butoben of propylparaben mixes composition.
Embodiment tri-:
A kind of gelatin Capsules, the mass ratio that comprises following component and each component is: acid system bone gelatin: 30 parts, enzyme process bone gelatin: 30 parts, polyacrylic resin: 30 parts, malt extract: 6 parts, parabens antiseptic: 0.8 part, ethanol: 60 parts, carrageenan: 13 parts, triethyl: 5 parts, glycerol: 4 parts, titanium dioxide: 1 part, magnesium stearate: 3 parts, ethyl hydroxybenzoate: 0.3 part, methyl parahydroxybenzoate: 5 parts, methyl-silicone oil: 0.6 part, food coloring: 3 parts, purified water: 70 parts, in the hydrochloric acid that described acid system bone gelatin is 5% by the animal aggregate after defat in concentration, soak and make, the temperature of hydrochloric acid solution is controlled at 15 ℃, aggregate after pickling carries out the washing of 4 times, until the residual salt acid content in washing water is lower than 0.1%, then aggregate is proceeded in the Muffle furnace of 600 ℃ and burn and finally obtain finished product acid system bone gelatin, described enzyme process bone gelatin passes through proteasome degradation after being mixed with water by animal aggregate, after enzymolysis, use the pH value to 9.0 of limestone regulator solution, then heat mixed solution to 85 ℃, keep obtaining glue after 1h, glue is first gone out particle by cottonseed cake, spent ion exchange resin is removed soluble inorganic salt ion again, last glue is dried and is obtained finished product enzyme process bone gelatin by freezer dryer, the particle diameter of described animal aggregate is 6mm, described food coloring adopts the natural Rhizoma Curcumae Longae of directly extracting from plant, beta-carotene, one or any several mixture in chlorophyll and Monas cuspurpureus Went, described parabens antiseptic is methyl hydroxybenzoate, ethyl hydroxybenzoate, the strongest and butoben of propylparaben mixes composition.
The present invention, writes benefit.
Above-described embodiment is to explanation of the present invention, is not limitation of the invention, any scheme after simple transformation of the present invention is all belonged to protection scope of the present invention.
Claims (9)
1. a gelatin Capsules, it is characterized in that: the mass ratio that comprises following component and each component is: acid system bone gelatin: 20～30 parts, enzyme process bone gelatin: 20～30 parts, polyacrylic resin: 20～30 parts, malt extract: 2～6 parts, parabens antiseptic: 0.2～0.8 part, ethanol: 40～60 parts, carrageenan: 5～13 parts, triethyl: 2～5 parts, glycerol: 1～4 part, titanium dioxide: 0.5～1 part, magnesium stearate: 1～3 part, ethyl hydroxybenzoate: 0.1～0.3 part, methyl parahydroxybenzoate: 2～5 parts, methyl-silicone oil: 0.2～0.6 part, food coloring: 1～3 part, purified water: 40～70 parts.
2. a kind of gelatin Capsules as claimed in claim 1, it is characterized in that: in the hydrochloric acid that described acid system bone gelatin is 3.5～5% by the animal aggregate after defat in concentration, soak and make, the temperature of hydrochloric acid solution is controlled at 15～17 ℃, aggregate after pickling carries out the washing of 2～4 times, until the residual salt acid content in washing water lower than 0.1%, then proceeds to aggregate in the Muffle furnace of 600 ℃, burn and finally obtain finished product acid system bone gelatin.
3. a kind of gelatin Capsules as claimed in claim 1, it is characterized in that: described enzyme process bone gelatin passes through proteasome degradation after being mixed with water by animal aggregate, after enzymolysis, use the pH value to 9.0 of limestone regulator solution, then heat mixed solution to 80～95 ℃, keep obtaining glue after 1h, glue is first gone out particle by cottonseed cake, then spent ion exchange resin removes soluble inorganic salt ion, and last glue is dried and is obtained finished product enzyme process bone gelatin by freezer dryer.
4. a kind of gelatin Capsules as claimed in claim 2 or claim 3, is characterized in that: the particle diameter of described animal aggregate is 3～12mm.
5. a kind of gelatin Capsules as claimed in claim 1, is characterized in that: described food coloring adopts the one or any several mixture in the natural Rhizoma Curcumae Longae, beta-carotene, chlorophyll and the Monas cuspurpureus Went that directly extract from plant.
6. a kind of gelatin Capsules as claimed in claim 1, is characterized in that: described parabens antiseptic is methyl hydroxybenzoate, ethyl hydroxybenzoate, propylparaben is the strongest and butoben mixes composition.
7. a kind of gelatin Capsules as claimed in claim 1, it is characterized in that: the mass ratio that comprises following component and each component is: acid system bone gelatin: 20 parts, enzyme process bone gelatin: 20 parts, polyacrylic resin: 20 parts, malt extract: 2 parts, parabens antiseptic: 0.2 part, ethanol: 40 parts, carrageenan: 5 parts, triethyl: 2 parts, glycerol: 1 part, titanium dioxide: 0.5 part, magnesium stearate: 1 part, ethyl hydroxybenzoate: 0.1 part, methyl parahydroxybenzoate: 2 parts, methyl-silicone oil: 0.2 part, food coloring: 1 part, purified water: 40 parts.
8. a kind of gelatin Capsules as claimed in claim 1, it is characterized in that: the mass ratio that comprises following component and each component is: acid system bone gelatin: 25 parts, enzyme process bone gelatin: 25 parts, polyacrylic resin: 25 parts, malt extract: 4 parts, parabens antiseptic: 0.5 part, ethanol: 50 parts, carrageenan: 9 parts, triethyl: 3 parts, glycerol: 2 parts, titanium dioxide: 0.8 part, magnesium stearate: 1.5 parts, ethyl hydroxybenzoate: 0.2 part, methyl parahydroxybenzoate: 3.5 parts, methyl-silicone oil: 0.4 part, food coloring: 2 parts, purified water: 55 parts.
9. a kind of gelatin Capsules as claimed in claim 1, it is characterized in that: the mass ratio that comprises following component and each component is: acid system bone gelatin: 30 parts, enzyme process bone gelatin: 30 parts, polyacrylic resin: 30 parts, malt extract: 6 parts, parabens antiseptic: 0.8 part, ethanol: 60 parts, carrageenan: 13 parts, triethyl: 5 parts, glycerol: 4 parts, titanium dioxide: 1 part, magnesium stearate: 3 parts, ethyl hydroxybenzoate: 0.3 part, methyl parahydroxybenzoate: 5 parts, methyl-silicone oil: 0.6 part, food coloring: 3 parts, purified water: 70 parts.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410364814.3A CN104173317A (en) | 2014-07-29 | 2014-07-29 | Gelatin hollow capsule |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410364814.3A CN104173317A (en) | 2014-07-29 | 2014-07-29 | Gelatin hollow capsule |
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| CN104173317A true CN104173317A (en) | 2014-12-03 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201410364814.3A Pending CN104173317A (en) | 2014-07-29 | 2014-07-29 | Gelatin hollow capsule |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104544051A (en) * | 2014-12-15 | 2015-04-29 | 浙江宏辉胶丸有限公司 | Hollow capsule adopting lactobacillus acidophilus |
| CN104605227A (en) * | 2015-01-14 | 2015-05-13 | 浙江工业大学 | Hollow capsule with health-care function |
| CN105853388A (en) * | 2016-04-25 | 2016-08-17 | 夏放军 | Health care hollow capsule and preparation method thereof |
| CN105853390A (en) * | 2016-05-20 | 2016-08-17 | 夏放军 | Natural harmless hollow capsules and preparation method thereof |
| CN107233329A (en) * | 2017-05-12 | 2017-10-10 | 安徽黄山胶囊股份有限公司 | A kind of instant Capsules and preparation method thereof |
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| CN101317830A (en) * | 2008-07-10 | 2008-12-10 | 青岛益青药用胶囊有限公司 | Enteric hollow capsule and preparation thereof |
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2014
- 2014-07-29 CN CN201410364814.3A patent/CN104173317A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101317830A (en) * | 2008-07-10 | 2008-12-10 | 青岛益青药用胶囊有限公司 | Enteric hollow capsule and preparation thereof |
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| 余群力，冯玉萍: "《家畜副产品综合利用》", 28 February 2014, 中国轻工业出版社 * |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104544051A (en) * | 2014-12-15 | 2015-04-29 | 浙江宏辉胶丸有限公司 | Hollow capsule adopting lactobacillus acidophilus |
| CN104605227A (en) * | 2015-01-14 | 2015-05-13 | 浙江工业大学 | Hollow capsule with health-care function |
| CN105853388A (en) * | 2016-04-25 | 2016-08-17 | 夏放军 | Health care hollow capsule and preparation method thereof |
| CN105853390A (en) * | 2016-05-20 | 2016-08-17 | 夏放军 | Natural harmless hollow capsules and preparation method thereof |
| CN107233329A (en) * | 2017-05-12 | 2017-10-10 | 安徽黄山胶囊股份有限公司 | A kind of instant Capsules and preparation method thereof |
| CN107233329B (en) * | 2017-05-12 | 2020-04-21 | 安徽黄山胶囊股份有限公司 | Instant hollow capsule and preparation method thereof |
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