CN104544051A - Hollow capsule adopting lactobacillus acidophilus - Google Patents
Hollow capsule adopting lactobacillus acidophilus Download PDFInfo
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- CN104544051A CN104544051A CN201410778048.5A CN201410778048A CN104544051A CN 104544051 A CN104544051 A CN 104544051A CN 201410778048 A CN201410778048 A CN 201410778048A CN 104544051 A CN104544051 A CN 104544051A
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- lactobacillus acidophilus
- ethanol
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- powder
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- 240000001046 Lactobacillus acidophilus Species 0.000 title claims abstract description 63
- 235000013956 Lactobacillus acidophilus Nutrition 0.000 title claims abstract description 63
- 229940039695 lactobacillus acidophilus Drugs 0.000 title claims abstract description 63
- 239000002775 capsule Substances 0.000 title claims abstract description 30
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 59
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 27
- 239000000843 powder Substances 0.000 claims abstract description 27
- 108010010803 Gelatin Proteins 0.000 claims abstract description 21
- 239000003814 drug Substances 0.000 claims abstract description 21
- 229920000159 gelatin Polymers 0.000 claims abstract description 21
- 239000008273 gelatin Substances 0.000 claims abstract description 21
- 235000019322 gelatine Nutrition 0.000 claims abstract description 21
- 235000011852 gelatine desserts Nutrition 0.000 claims abstract description 21
- 210000000988 bone and bone Anatomy 0.000 claims abstract description 20
- 238000000034 method Methods 0.000 claims abstract description 20
- OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 claims abstract description 13
- GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 claims abstract description 13
- 235000013871 bee wax Nutrition 0.000 claims abstract description 13
- 239000012166 beeswax Substances 0.000 claims abstract description 13
- 239000000648 calcium alginate Substances 0.000 claims abstract description 13
- 235000010410 calcium alginate Nutrition 0.000 claims abstract description 13
- 229960002681 calcium alginate Drugs 0.000 claims abstract description 13
- OKHHGHGGPDJQHR-YMOPUZKJSA-L calcium;(2s,3s,4s,5s,6r)-6-[(2r,3s,4r,5s,6r)-2-carboxy-6-[(2r,3s,4r,5s,6r)-2-carboxylato-4,5,6-trihydroxyoxan-3-yl]oxy-4,5-dihydroxyoxan-3-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylate Chemical compound [Ca+2].O[C@@H]1[C@H](O)[C@H](O)O[C@@H](C([O-])=O)[C@H]1O[C@H]1[C@@H](O)[C@@H](O)[C@H](O[C@H]2[C@H]([C@@H](O)[C@H](O)[C@H](O2)C([O-])=O)O)[C@H](C(O)=O)O1 OKHHGHGGPDJQHR-YMOPUZKJSA-L 0.000 claims abstract description 13
- 229940041514 candida albicans extract Drugs 0.000 claims abstract description 13
- 235000011187 glycerol Nutrition 0.000 claims abstract description 13
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims abstract description 13
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims abstract description 13
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims abstract description 13
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims abstract description 13
- 239000008213 purified water Substances 0.000 claims abstract description 13
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 13
- 239000012138 yeast extract Substances 0.000 claims abstract description 13
- 102000004190 Enzymes Human genes 0.000 claims description 19
- 108090000790 Enzymes Proteins 0.000 claims description 19
- 230000008569 process Effects 0.000 claims description 19
- 239000000576 food coloring agent Substances 0.000 claims description 18
- 239000001856 Ethyl cellulose Substances 0.000 claims description 12
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 claims description 12
- 235000009754 Vitis X bourquina Nutrition 0.000 claims description 12
- 235000012333 Vitis X labruscana Nutrition 0.000 claims description 12
- 235000014787 Vitis vinifera Nutrition 0.000 claims description 12
- 235000010443 alginic acid Nutrition 0.000 claims description 12
- 229920000615 alginic acid Polymers 0.000 claims description 12
- 235000019325 ethyl cellulose Nutrition 0.000 claims description 12
- 229920001249 ethyl cellulose Polymers 0.000 claims description 12
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 claims description 12
- 239000010931 gold Substances 0.000 claims description 12
- 229910052737 gold Inorganic materials 0.000 claims description 12
- 238000001556 precipitation Methods 0.000 claims description 12
- 229920002545 silicone oil Polymers 0.000 claims description 12
- 239000006228 supernatant Substances 0.000 claims description 9
- 244000163122 Curcuma domestica Species 0.000 claims description 6
- 235000003392 Curcuma domestica Nutrition 0.000 claims description 6
- 241000196324 Embryophyta Species 0.000 claims description 6
- OENHQHLEOONYIE-UKMVMLAPSA-N all-trans beta-carotene Natural products CC=1CCCC(C)(C)C=1/C=C/C(/C)=C/C=C/C(/C)=C/C=C/C=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C OENHQHLEOONYIE-UKMVMLAPSA-N 0.000 claims description 6
- 235000013734 beta-carotene Nutrition 0.000 claims description 6
- TUPZEYHYWIEDIH-WAIFQNFQSA-N beta-carotene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CCCC1(C)C)C=CC=C(/C)C=CC2=CCCCC2(C)C TUPZEYHYWIEDIH-WAIFQNFQSA-N 0.000 claims description 6
- 239000011648 beta-carotene Substances 0.000 claims description 6
- 229960002747 betacarotene Drugs 0.000 claims description 6
- 239000003795 chemical substances by application Substances 0.000 claims description 6
- 235000019804 chlorophyll Nutrition 0.000 claims description 6
- 229930002875 chlorophyll Natural products 0.000 claims description 6
- ATNHDLDRLWWWCB-AENOIHSZSA-M chlorophyll a Chemical compound C1([C@@H](C(=O)OC)C(=O)C2=C3C)=C2N2C3=CC(C(CC)=C3C)=[N+]4C3=CC3=C(C=C)C(C)=C5N3[Mg-2]42[N+]2=C1[C@@H](CCC(=O)OC\C=C(/C)CCC[C@H](C)CCC[C@H](C)CCCC(C)C)[C@H](C)C2=C5 ATNHDLDRLWWWCB-AENOIHSZSA-M 0.000 claims description 6
- 238000004040 coloring Methods 0.000 claims description 6
- 235000003373 curcuma longa Nutrition 0.000 claims description 6
- 235000013305 food Nutrition 0.000 claims description 6
- 238000004108 freeze drying Methods 0.000 claims description 6
- 239000000203 mixture Substances 0.000 claims description 6
- 235000015097 nutrients Nutrition 0.000 claims description 6
- 239000003223 protective agent Substances 0.000 claims description 6
- 235000013976 turmeric Nutrition 0.000 claims description 6
- OENHQHLEOONYIE-JLTXGRSLSA-N β-Carotene Chemical compound CC=1CCCC(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C OENHQHLEOONYIE-JLTXGRSLSA-N 0.000 claims description 6
- 239000002244 precipitate Substances 0.000 claims description 3
- 238000002360 preparation method Methods 0.000 claims description 3
- 238000002390 rotary evaporation Methods 0.000 claims description 3
- 240000006365 Vitis vinifera Species 0.000 claims 4
- 210000002784 stomach Anatomy 0.000 abstract description 6
- 229940079593 drug Drugs 0.000 abstract description 5
- 210000000936 intestine Anatomy 0.000 abstract description 3
- 230000036541 health Effects 0.000 abstract description 2
- FJKROLUGYXJWQN-UHFFFAOYSA-N 4-hydroxybenzoic acid Chemical compound OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 abstract 1
- 241001474374 Blennius Species 0.000 abstract 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 239000000499 gel Substances 0.000 abstract 1
- 229940087603 grape seed extract Drugs 0.000 abstract 1
- 235000002532 grape seed extract Nutrition 0.000 abstract 1
- 239000000049 pigment Substances 0.000 abstract 1
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 abstract 1
- 239000000600 sorbitol Substances 0.000 abstract 1
- 239000001717 vitis vinifera seed extract Substances 0.000 abstract 1
- 241000219095 Vitis Species 0.000 description 8
- 230000000694 effects Effects 0.000 description 3
- 230000000857 drug effect Effects 0.000 description 2
- 230000007160 gastrointestinal dysfunction Effects 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 230000008485 antagonism Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 210000003238 esophagus Anatomy 0.000 description 1
- 230000002964 excitative effect Effects 0.000 description 1
- 210000001156 gastric mucosa Anatomy 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 239000003292 glue Substances 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 235000013402 health food Nutrition 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 244000000010 microbial pathogen Species 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 210000000214 mouth Anatomy 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 230000035764 nutrition Effects 0.000 description 1
- 229940127249 oral antibiotic Drugs 0.000 description 1
- 210000004798 organs belonging to the digestive system Anatomy 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 210000002345 respiratory system Anatomy 0.000 description 1
- 210000003296 saliva Anatomy 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2400/00—Lactic or propionic acid bacteria
- A23V2400/11—Lactobacillus
- A23V2400/113—Acidophilus
Landscapes
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
- Jellies, Jams, And Syrups (AREA)
Abstract
The invention discloses a hollow capsule adopting lactobacillus acidophilus. The hollow capsule is prepared from the following components in parts by mass: 5-10 parts of lactobacillus acidophilus powder, 30-40 parts of enzyme-method bone gelatin, 5-15 parts of seaweed gel, 10-20 parts of calcium alginate, 10-18 parts of hydroxypropyl methyl cellulose, 15-25 parts of ethyecellulose, 30-40 parts of ethanol, 2-6 parts of yeast extract, 2-8 parts of grape seed extract, 1-4 parts of beeswax, 2-6 parts of maltose, 1-4 parts of glycerol, 1-3 parts of sorbitol, 2-5 parts of triethyl ester, 0.5-1 part of edible pigment, 0.2-0.4 part of paraben, 0.2-0.6 part of methyl silicone oil and 70-100 parts of purified water. According to the hollow capsule, the lactobacillus acidophilus powder is added so that the intestines and stomach health function of the hollow capsule can be enhanced, and medicines can be sufficiently absorbed by the intestines and stomach.
Description
[technical field]
The present invention relates to the technical field of health food, particularly adopt the technical field of the Capsules of lactobacillus acidophilus.
[background technology]
Most medicine is to esophagus and gastric mucosa powder excitatory or particle, or mouthfeel bad, be easy to volatilization, easily decomposed by saliva in the oral cavity, and easily suck the medicine of tracheae, in order to ensure drug effect, facilitate patients, medicine capsule wraps up by normal employing.These medicines incapsulate, and have both protected the medicine property of medicine and have not been destroyed, also protected digestive organs and respiratory tract.Removing capsule shells may cause drug wastage, drug waste, drug effect to reduce.In addition, some medicine needs solution absorption in intestines, and capsule is a kind of protection, and protection medicine is not by stomach acids destroy.Capsules, at the bladder pharmaceutically referring to make with extraordinary filmogen (as gelatin, cellulose, polysaccharide etc.), content (as powdery, liquid various kinds of drug etc.) or according to dosage load wherein, is convenient to swallow.Existing Capsules just plays the effect of protection medicine mostly, and itself is without any health-care effect, is therefore necessary to propose a kind of Capsules adopting lactobacillus acidophilus.
[summary of the invention]
Object of the present invention solves the problems of the prior art exactly, proposes a kind of Capsules adopting lactobacillus acidophilus, can make the health care of Capsules increase to stomach, and can ensure that medicine can be absorbed fully by stomach.
For achieving the above object, the present invention proposes a kind of Capsules adopting lactobacillus acidophilus, comprise following component and the mass ratio of each component is: 5 ~ 10 parts, lactobacillus acidophilus powder, enzyme process bone gelatin: 30 ~ 40 parts, algin: 5 ~ 15 parts, calcium alginate: 10 ~ 20 parts, hydroxypropyl methylcellulose: 10 ~ 18 parts, ethyl cellulose: 15 ~ 25 parts, ethanol: 30 ~ 40 parts, yeast extract: 2 ~ 6 parts, grape pip gets thing: 2 ~ 8 parts, beeswax: 1 ~ 4, maltose: 2 ~ 6 parts, glycerine: 1 ~ 4 part, sorbierite: 1 ~ 3 part, triethyl: 2 ~ 5 parts, food coloring: 0.5 ~ 1 part, Nepal's gold fat: 0.2 ~ 0.4 part, methyl-silicone oil: 0.2 ~ 0.6 part, purified water: 70 ~ 100 parts.
As preferably, the preparation method of described lactobacillus acidophilus powder is as follows:
A) get lactobacillus acidophilus nutrient solution, by lactobacillus acidophilus nutrient solution in mass ratio 1:20 be dipped in 95% ethanol 30 minutes, leave standstill after isolate supernatant, precipitate stand-by;
B) ethanol then adding equivalent, in precipitation, isolates supernatant after leaving standstill 30 minutes, and supernatant rotary evaporation reclaims ethanol, and the lactobacillus acidophilus precipitation after alcohol precipitation of going to the bottom is for subsequent use;
C) adopt centrifugal freeze dryer to carry out freeze-drying lactobacillus acidophilus precipitation, rotating speed is 800 ~ 1000 revs/min, and the lactobacillus acidophilus porphyrize after freeze-drying is made lactobacillus acidophilus powder.
As preferably, described sorbierite is the protective agent of lactobacillus acidophilus powder.
As preferably, described enzyme process bone gelatin mixes with the ratio of ethanol according to 1:1.
As preferably, described food coloring adopts the one or any several mixture in the turmeric of natural extracting directly from plant, beta carotene, chlorophyll and red colouring agent for food, also used as a Chinese medicine.
As preferably, comprise following component and the mass ratio of each component is: 5 parts, lactobacillus acidophilus powder, enzyme process bone gelatin: 30 parts, algin: 5 parts, calcium alginate: 10 parts, hydroxypropyl methylcellulose: 10 parts, ethyl cellulose: 15 parts, ethanol: 30 parts, yeast extract: 2 parts, grape pip gets thing: 2 parts, beeswax: 1, maltose: 2 parts, glycerine: 1 part, sorbierite: 1 part, triethyl: 2 parts, food coloring: 0.5 part, Nepal's gold fat: 0.2 part, methyl-silicone oil: 0.2 part, purified water: 70 parts.
As preferably, comprise following component and the mass ratio of each component is: 8 parts, lactobacillus acidophilus powder, enzyme process bone gelatin: 35 parts, algin: 10 parts, calcium alginate: 15 parts, hydroxypropyl methylcellulose: 14 parts, ethyl cellulose: 20 parts, ethanol: 35 parts, yeast extract: 4 parts, grape pip gets thing: 5 parts, beeswax: 3, maltose: 5 parts, glycerine: 3 parts, sorbierite: 2 parts, triethyl: 4 parts, food coloring: 0.8 part, Nepal's gold fat: 0.3 part, methyl-silicone oil: 0.4 part, purified water: 90 parts.
As preferably, comprise following component and the mass ratio of each component is: 10 parts, lactobacillus acidophilus powder, enzyme process bone gelatin: 40 parts, algin: 15 parts, calcium alginate: 20 parts, hydroxypropyl methylcellulose: 18 parts, ethyl cellulose: 25 parts, ethanol: 40 parts, yeast extract: 6 parts, grape pip gets thing: 8 parts, beeswax: 4, maltose: 6 parts, glycerine: 4 parts, sorbierite: 3 parts, triethyl: 5 parts, food coloring: 1 part, Nepal's gold fat: 0.4 part, methyl-silicone oil: 0.6 part, purified water: 100 parts.
Beneficial effect of the present invention: the present invention is by joining in Capsules by lactobacillus acidophilus, and lactobacillus acidophilus is the main probio of stomach, can adjust gut flora balance, suppress the propagation of enteron aisle undesirable microorganism.Lactobacillus acidophilus has antagonism to pathogenic microorganisms.Particularly the infant of gastrointestinal dysfunction and some Long-term Oral antibiotic are caused to the patient of gastrointestinal dysfunction; the flora in enteron aisle can be made rapidly to recover normal equilibrium; suppress the propagation of spoilage organisms; so have good nutrition health-care functions; enzyme process bone gelatin makes glue have good viscosity, freezes the physicochemical property such as power and transparency, improves the effect of the protection property of medicine of Capsules.
[detailed description of the invention]
A kind of Capsules adopting lactobacillus acidophilus of the present invention, comprise following component and the mass ratio of each component is: 5 ~ 10 parts, lactobacillus acidophilus powder, enzyme process bone gelatin: 30 ~ 40 parts, algin: 5 ~ 15 parts, calcium alginate: 10 ~ 20 parts, hydroxypropyl methylcellulose: 10 ~ 18 parts, ethyl cellulose: 15 ~ 25 parts, ethanol: 30 ~ 40 parts, yeast extract: 2 ~ 6 parts, grape pip gets thing: 2 ~ 8 parts, beeswax: 1 ~ 4, maltose: 2 ~ 6 parts, glycerine: 1 ~ 4 part, sorbierite: 1 ~ 3 part, triethyl: 2 ~ 5 parts, food coloring: 0.5 ~ 1 part, Nepal's gold fat: 0.2 ~ 0.4 part, methyl-silicone oil: 0.2 ~ 0.6 part, purified water: 70 ~ 100 parts.
The preparation method of described lactobacillus acidophilus powder is as follows:
A) get lactobacillus acidophilus nutrient solution, by lactobacillus acidophilus nutrient solution in mass ratio 1:20 be dipped in 95% ethanol 30 minutes, leave standstill after isolate supernatant, precipitate stand-by;
B) ethanol then adding equivalent, in precipitation, isolates supernatant after leaving standstill 30 minutes, and supernatant rotary evaporation reclaims ethanol, and the lactobacillus acidophilus precipitation after alcohol precipitation of going to the bottom is for subsequent use;
C) adopt centrifugal freeze dryer to carry out freeze-drying lactobacillus acidophilus precipitation, rotating speed is 800 ~ 1000 revs/min, and the lactobacillus acidophilus porphyrize after freeze-drying is made lactobacillus acidophilus powder.
Described sorbierite is the protective agent of lactobacillus acidophilus powder; described enzyme process bone gelatin mixes with the ratio of ethanol according to 1:1, and described food coloring adopts the one or any several mixture in the turmeric of natural extracting directly from plant, beta carotene, chlorophyll and red colouring agent for food, also used as a Chinese medicine.
Embodiment one:
A kind of Capsules adopting lactobacillus acidophilus, comprise following component and the mass ratio of each component is: 5 parts, lactobacillus acidophilus powder, enzyme process bone gelatin: 30 parts, algin: 5 parts, calcium alginate: 10 parts, hydroxypropyl methylcellulose: 10 parts, ethyl cellulose: 15 parts, ethanol: 30 parts, yeast extract: 2 parts, grape pip gets thing: 2 parts, beeswax: 1, maltose: 2 parts, glycerine: 1 part, sorbierite: 1 part, triethyl: 2 parts, food coloring: 0.5 part, Nepal's gold fat: 0.2 part, methyl-silicone oil: 0.2 part, purified water: 70 parts, described sorbierite is the protective agent of lactobacillus acidophilus powder, described enzyme process bone gelatin mixes with the ratio of ethanol according to 1:1, described food coloring adopts the turmeric of natural extracting directly from plant, beta carotene, one or any several mixture in chlorophyll and red colouring agent for food, also used as a Chinese medicine.
Embodiment two:
A kind of Capsules adopting lactobacillus acidophilus, comprise following component and the mass ratio of each component is: 8 parts, lactobacillus acidophilus powder, enzyme process bone gelatin: 35 parts, algin: 10 parts, calcium alginate: 15 parts, hydroxypropyl methylcellulose: 14 parts, ethyl cellulose: 20 parts, ethanol: 35 parts, yeast extract: 4 parts, grape pip gets thing: 5 parts, beeswax: 3, maltose: 5 parts, glycerine: 3 parts, sorbierite: 2 parts, triethyl: 4 parts, food coloring: 0.8 part, Nepal's gold fat: 0.3 part, methyl-silicone oil: 0.4 part, purified water: 90 parts, described sorbierite is the protective agent of lactobacillus acidophilus powder, described enzyme process bone gelatin mixes with the ratio of ethanol according to 1:1, described food coloring adopts the turmeric of natural extracting directly from plant, beta carotene, one or any several mixture in chlorophyll and red colouring agent for food, also used as a Chinese medicine.
Embodiment three:
A kind of Capsules adopting lactobacillus acidophilus, comprise following component and the mass ratio of each component is: 10 parts, lactobacillus acidophilus powder, enzyme process bone gelatin: 40 parts, algin: 15 parts, calcium alginate: 20 parts, hydroxypropyl methylcellulose: 18 parts, ethyl cellulose: 25 parts, ethanol: 40 parts, yeast extract: 6 parts, grape pip gets thing: 8 parts, beeswax: 4, maltose: 6 parts, glycerine: 4 parts, sorbierite: 3 parts, triethyl: 5 parts, food coloring: 1 part, Nepal's gold fat: 0.4 part, methyl-silicone oil: 0.6 part, purified water: 100 parts, described sorbierite is the protective agent of lactobacillus acidophilus powder, described enzyme process bone gelatin mixes with the ratio of ethanol according to 1:1, described food coloring adopts the turmeric of natural extracting directly from plant, beta carotene, one or any several mixture in chlorophyll and red colouring agent for food, also used as a Chinese medicine.
Above-described embodiment is to explanation of the present invention, is not limitation of the invention, anyly all belongs to protection scope of the present invention to the scheme after simple transformation of the present invention.
Claims (8)
1. one kind adopts the Capsules of lactobacillus acidophilus, it is characterized in that: comprise following component and the mass ratio of each component is: 5 ~ 10 parts, lactobacillus acidophilus powder, enzyme process bone gelatin: 30 ~ 40 parts, algin: 5 ~ 15 parts, calcium alginate: 10 ~ 20 parts, hydroxypropyl methylcellulose: 10 ~ 18 parts, ethyl cellulose: 15 ~ 25 parts, ethanol: 30 ~ 40 parts, yeast extract: 2 ~ 6 parts, grape pip gets thing: 2 ~ 8 parts, beeswax: 1 ~ 4, maltose: 2 ~ 6 parts, glycerine: 1 ~ 4 part, sorbierite: 1 ~ 3 part, triethyl: 2 ~ 5 parts, food coloring: 0.5 ~ 1 part, Nepal's gold fat: 0.2 ~ 0.4 part, methyl-silicone oil: 0.2 ~ 0.6 part, purified water: 70 ~ 100 parts.
2. a kind of Capsules adopting lactobacillus acidophilus as claimed in claim 1, is characterized in that: the preparation method of described lactobacillus acidophilus powder is as follows:
A) get lactobacillus acidophilus nutrient solution, by lactobacillus acidophilus nutrient solution in mass ratio 1:20 be dipped in 95% ethanol 30 minutes, leave standstill after isolate supernatant, precipitate stand-by;
B) ethanol then adding equivalent, in precipitation, isolates supernatant after leaving standstill 30 minutes, and supernatant rotary evaporation reclaims ethanol, and the lactobacillus acidophilus precipitation after alcohol precipitation of going to the bottom is for subsequent use;
C) adopt centrifugal freeze dryer to carry out freeze-drying lactobacillus acidophilus precipitation, rotating speed is 800 ~ 1000 revs/min, and the lactobacillus acidophilus porphyrize after freeze-drying is made lactobacillus acidophilus powder.
3. a kind of Capsules adopting lactobacillus acidophilus as claimed in claim 1, is characterized in that: described sorbierite is the protective agent of lactobacillus acidophilus powder.
4. a kind of Capsules adopting lactobacillus acidophilus as claimed in claim 1, is characterized in that: described enzyme process bone gelatin mixes with the ratio of ethanol according to 1:1.
5. a kind of Capsules adopting lactobacillus acidophilus as claimed in claim 1, is characterized in that: described food coloring adopts the one or any several mixture in the turmeric of natural extracting directly from plant, beta carotene, chlorophyll and red colouring agent for food, also used as a Chinese medicine.
6. a kind of Capsules adopting lactobacillus acidophilus as claimed in claim 1, it is characterized in that: comprise following component and the mass ratio of each component is: 5 parts, lactobacillus acidophilus powder, enzyme process bone gelatin: 30 parts, algin: 5 parts, calcium alginate: 10 parts, hydroxypropyl methylcellulose: 10 parts, ethyl cellulose: 15 parts, ethanol: 30 parts, yeast extract: 2 parts, grape pip gets thing: 2 parts, beeswax: 1, maltose: 2 parts, glycerine: 1 part, sorbierite: 1 part, triethyl: 2 parts, food coloring: 0.5 part, Nepal's gold fat: 0.2 part, methyl-silicone oil: 0.2 part, purified water: 70 parts.
7. a kind of Capsules adopting lactobacillus acidophilus as claimed in claim 1, it is characterized in that: comprise following component and the mass ratio of each component is: 8 parts, lactobacillus acidophilus powder, enzyme process bone gelatin: 35 parts, algin: 10 parts, calcium alginate: 15 parts, hydroxypropyl methylcellulose: 14 parts, ethyl cellulose: 20 parts, ethanol: 35 parts, yeast extract: 4 parts, grape pip gets thing: 5 parts, beeswax: 3, maltose: 5 parts, glycerine: 3 parts, sorbierite: 2 parts, triethyl: 4 parts, food coloring: 0.8 part, Nepal's gold fat: 0.3 part, methyl-silicone oil: 0.4 part, purified water: 90 parts.
8. a kind of Capsules adopting lactobacillus acidophilus as claimed in claim 1, it is characterized in that: comprise following component and the mass ratio of each component is: 10 parts, lactobacillus acidophilus powder, enzyme process bone gelatin: 40 parts, algin: 15 parts, calcium alginate: 20 parts, hydroxypropyl methylcellulose: 18 parts, ethyl cellulose: 25 parts, ethanol: 40 parts, yeast extract: 6 parts, grape pip gets thing: 8 parts, beeswax: 4, maltose: 6 parts, glycerine: 4 parts, sorbierite: 3 parts, triethyl: 5 parts, food coloring: 1 part, Nepal's gold fat: 0.4 part, methyl-silicone oil: 0.6 part, purified water: 100 parts.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410778048.5A CN104544051B (en) | 2014-12-15 | 2014-12-15 | A kind of Capsules using bacillus acidophilus |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN107233329A (en) * | 2017-05-12 | 2017-10-10 | 安徽黄山胶囊股份有限公司 | A kind of instant Capsules and preparation method thereof |
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| CN102440375A (en) * | 2010-09-30 | 2012-05-09 | 杜涵 | Probiotic for children and preparation method of probiotic |
| CN103191434A (en) * | 2013-03-28 | 2013-07-10 | 姜晓东 | Botanical non-toxic empty capsule and preparation process thereof |
| CN103992998A (en) * | 2014-05-09 | 2014-08-20 | 陕西科技大学 | Method of preparing lactobacillus acidophilus microcapsule by utilization of chitosan/xanthan gum and applications of the microcapsule |
| CN104107174A (en) * | 2014-07-08 | 2014-10-22 | 浙江越溪胶丸有限公司 | Health hollow capsule |
| CN104146982A (en) * | 2014-07-29 | 2014-11-19 | 浙江益立胶囊有限公司 | Hollow enteric capsule |
| CN104173317A (en) * | 2014-07-29 | 2014-12-03 | 浙江益立胶囊有限公司 | Gelatin hollow capsule |
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Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102440375A (en) * | 2010-09-30 | 2012-05-09 | 杜涵 | Probiotic for children and preparation method of probiotic |
| CN103191434A (en) * | 2013-03-28 | 2013-07-10 | 姜晓东 | Botanical non-toxic empty capsule and preparation process thereof |
| CN103992998A (en) * | 2014-05-09 | 2014-08-20 | 陕西科技大学 | Method of preparing lactobacillus acidophilus microcapsule by utilization of chitosan/xanthan gum and applications of the microcapsule |
| CN104107174A (en) * | 2014-07-08 | 2014-10-22 | 浙江越溪胶丸有限公司 | Health hollow capsule |
| CN104146982A (en) * | 2014-07-29 | 2014-11-19 | 浙江益立胶囊有限公司 | Hollow enteric capsule |
| CN104173317A (en) * | 2014-07-29 | 2014-12-03 | 浙江益立胶囊有限公司 | Gelatin hollow capsule |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107233329A (en) * | 2017-05-12 | 2017-10-10 | 安徽黄山胶囊股份有限公司 | A kind of instant Capsules and preparation method thereof |
| CN107233329B (en) * | 2017-05-12 | 2020-04-21 | 安徽黄山胶囊股份有限公司 | Instant hollow capsule and preparation method thereof |
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| CN104544051B (en) | 2016-08-24 |
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