CN106389378A - Pectin hollow capsule - Google Patents
Pectin hollow capsule Download PDFInfo
- Publication number
- CN106389378A CN106389378A CN201610916954.6A CN201610916954A CN106389378A CN 106389378 A CN106389378 A CN 106389378A CN 201610916954 A CN201610916954 A CN 201610916954A CN 106389378 A CN106389378 A CN 106389378A
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- CN
- China
- Prior art keywords
- parts
- pectin
- capsuleses
- hollow capsule
- aqueous dispersion
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Inorganic Chemistry (AREA)
- Jellies, Jams, And Syrups (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention discloses a pectin hollow capsule. The pectin hollow capsule comprises, by mass, 50 to 65 parts of pectin powder, 15 to 20 parts of polyacrylic acid resin, 15 to 20 parts of an ethyl cellulose aqueous dispersion, 10 to 15 parts of a cellulose acetate aqueous dispersion, 2 to 3 parts of polyethylene glycol, 10 to 20 parts of polylactic acid, 3 to 4 parts of triethyl ester, 2 to 3 parts of glycerin, 0.5-1 part of titanium dioxide, 1 to 3 parts of magnesium stearate, 0.1 to 0.3 parts of ethyl hydroxybenzoate, 2 to 5 parts of potassium citrate, 2 to 5 parts of starch, 0.2 to 0.6 parts of methyl silicone oil , 1 to 3 parts of food color and 80 to 100 parts of purified water. The pectin hollow capsule overcomes the defects of the existing capsule. Through use of appropriate pectin powder in the formula of the hollow capsule, the pectin hollow capsule protects the gastric mucosa and helps digestion and can prevent absorption of the medical powder until the medical powder enters the intestinal tract.
Description
Technical field
The present invention relates to pectin application technology technical field, particularly belong to a kind of pectin Capsuleses.
Background technology
The Capsuleses using at present are all to form gastric solubleness Capsuleses by after gelatin or plant gum machine-shaping；As at it
The enteric-coating material of the anti-gastric acid of outer cladding or not only anti-gastric acid but also the coating material of anti-intestinal juice (pH value >=6.8), are formed for enteric
Capsuleses and colonic-coated hollow capsule.The course of processing of Capsuleses is by colloidal sol, to dip in glue, drying, the demoulding, cutting and fit each
Plant operation to constitute, completed by professional automatic production line.Obtain gelatine capsule or plant gum capsule material (i.e. capsule in dry solidification
Shell) surface carries out enteric coating process or the Cotton seeds of anti-intestinal juice, then the operation such as drying solidification cooling, cutting obtains enteric
Capsuleses or colonic-coated hollow capsule.Gelatin is by connective tissues such as the skin of animal, bone, cartilage, ligament, tendons through hydrolysis or enzyme
The water soluble protein that solution obtains.Processing Capsuleses are to prevent from albumen from going mouldy to add oxybenzene esters preservative.Capsuleses
Moisture content generally 13～16%, the change for preventing water content leads to tacky, deformation, not can be stored in high temperature, high humidity bar
Under part, also should not leave in environment too cold or being dried, in order to avoid embrittlement.Preferably deposit in the dark, 15～25 DEG C of temperature, relatively wet
Degree 35%～65%.Capsule can improve to photaesthesia, the stability to thermally labile medicine, is conducive to improving biological utilisation
Degree, can cover bad smell and the bitterness of medicine simultaneously, be a kind of well accepted dosage form of patient；But it is not a kind of ideal glue
Capsule raw material, existing research pectin can use as the raw material of your Capsuleses, and pectin also has other well to inhale simultaneously
Attached property for adsorbing heavy metal of body.
Content of the invention
For the problems referred to above, it is an object of the invention to provide a kind of pectin Capsuleses, overcome prior art not
Foot, by adding suitable jelly powder in the formula of Capsuleses, plays protection gastric mucosa, digestive health care, with
When can protect medicated powder enter intestinal absorbed.
The technical solution used in the present invention is as follows：
A kind of pectin Capsuleses, including following components and the mass fraction of each component is：50～65 parts of jelly powder, poly- third
15～20 parts of olefin(e) acid resin, 15～20 parts of Aquacoat, 10～15 parts of cellulose acetate aqueous dispersion, poly- second two
2～3 parts of alcohol, 10～20 parts of polylactic acid, 3～4 parts of triethyl, 2～3 parts of glycerol, 0.5～1 part of titanium dioxide, magnesium stearate 1～3
Part, 0.1～0.3 part of ethyl hydroxybenzoate, 2～5 parts of potassium citrate, 2～5 parts of starch, 0.2～0.6 part of methyl-silicone oil, food coloring 1
～3 parts, 80～100 parts of purified water.
Described jelly powder degree of gelation>97 degree, esterification degree 52-58%, galacturonic acid>85%.
Described Aquacoat and cellulose acetate aqueous dispersion are according to 2.5:1.5 ratio is mixed.
Described food coloring adopts in the natural Rhizoma Curcumae Longae of extracting directly, beta-carotene, chlorophyll and Monas cuspurpureus Went from plant
One or any several mixture.
Compared with the prior art, beneficial effects of the present invention are as follows：
The present invention passes through to add pectin in Capsuleses, and pectin is one of plant acidic polysaccharose material, and pectin has
Adsorptivity well, can bond and eliminate Endophytic bacteria toxin and other harmful substances, as the lead in heavy metal, hydrargyrum and radioactivity
Element, plays Detoxication, pectin can also protect gastrointestinal tract mucous, from coarse food stimulate, promote ulcer surface healing, fit
It is suitable for patients with gastric disease, promotes bile secretion, strengthen gastrointestinal peristalsiss, help food digestion, aqueous polymer dispersion can subtract simultaneously
The usage amount of few organic solvent, reduces the water yield of the required evaporation of coating process, reduces energy consumption, shorten the process time simultaneously,
Component can be protected not to be damaged, simultaneously using enzyme process skin gelatin so that glue has good viscosity, jelly power and transparency etc.
Physicochemical property, improves the quality of enteric hollow capsule.
Specific embodiment
A kind of pectin Capsuleses of embodiment 1, including following components and the mass fraction of each component is：65 parts of jelly powder,
20 parts of polyacrylic resin, 20 parts of Aquacoat, 15 parts of cellulose acetate aqueous dispersion, 3 parts of Polyethylene Glycol, gathers
20 parts of lactic acid, 4 parts of triethyl, 3 parts of glycerol, 1 part of titanium dioxide, 3 parts of magnesium stearate, 0.3 part of ethyl hydroxybenzoate, 5 parts of potassium citrate, forms sediment
5 parts of powder, 0.6 part of methyl-silicone oil, 3 parts of food coloring, 100 parts of purified water；Jelly powder degree of gelation>97 degree, esterification degree 52-58%,
Galacturonic acid>85%；Aquacoat and cellulose acetate aqueous dispersion are according to 2.5:1.5 ratio is mixed
Close；Food coloring adopt natural one of the Rhizoma Curcumae Longae of extracting directly, beta-carotene, chlorophyll and Monas cuspurpureus Went from plant or
Arbitrarily several mixture of person.
A kind of pectin Capsuleses of embodiment 2, including following components and the mass fraction of each component is：50 parts of jelly powder,
15 parts of polyacrylic resin, 15 parts of Aquacoat, 10 parts of cellulose acetate aqueous dispersion, 2 parts of Polyethylene Glycol, gathers
10 parts of lactic acid, 3 parts of triethyl, 2 parts of glycerol, 0.5 part of titanium dioxide, 1 part of magnesium stearate, 0.1 part of ethyl hydroxybenzoate, 2 parts of potassium citrate,
2 parts of starch, 0.2 part of methyl-silicone oil, 1 part of food coloring, 80 parts of purified water；Jelly powder degree of gelation>97 degree, esterification degree 52-58%,
Galacturonic acid>85%；Aquacoat and cellulose acetate aqueous dispersion are according to 2.5:1.5 ratio is mixed
Close；Food coloring adopt natural one of the Rhizoma Curcumae Longae of extracting directly, beta-carotene, chlorophyll and Monas cuspurpureus Went from plant or
Arbitrarily several mixture of person.
A kind of pectin Capsuleses of embodiment 3, including following components and the mass fraction of each component is：60 parts of jelly powder,
18 parts of polyacrylic resin, 18 parts of Aquacoat, 12 parts of cellulose acetate aqueous dispersion, 2.5 parts of Polyethylene Glycol,
15 parts of polylactic acid, 3.5 parts of triethyl, 2.5 parts of glycerol, 0.8 part of titanium dioxide, 2 parts of magnesium stearate, 0.2 part of ethyl hydroxybenzoate, citric acid
3 parts of potassium, 4 parts of starch, 0.4 part of methyl-silicone oil, 2 parts of food coloring, 90 parts of purified water；Jelly powder degree of gelation>97 degree, esterification degree
52-58%, galacturonic acid>85%；Aquacoat and cellulose acetate aqueous dispersion are according to 2.5:1.5 ratio
Example is mixed；Food coloring adopts in the natural Rhizoma Curcumae Longae of extracting directly, beta-carotene, chlorophyll and Monas cuspurpureus Went from plant
One or any several mixture.
Ultimate principle, principal character and the advantages of the present invention of the present invention have been shown and described above.The technology of the industry
, it should be appreciated that the present invention is not restricted to the described embodiments, the simply explanation described in above-described embodiment and description is originally for personnel
The principle of invention, without departing from the spirit and scope of the present invention, the present invention also has various changes and modifications, these changes
Change and improvement both falls within scope of the claimed invention.Claimed scope by appending claims and its
Equivalent thereof.
Claims (4)
1. a kind of pectin Capsuleses it is characterised in that：Including following components and the mass fraction of each component is：Jelly powder 50～
65 parts, 15～20 parts of polyacrylic resin, 15～20 parts of Aquacoat, cellulose acetate aqueous dispersion 10～15
Part, 2～3 parts of Polyethylene Glycol, 10～20 parts of polylactic acid, 3～4 parts of triethyl, 2～3 parts of glycerol, 0.5～1 part of titanium dioxide, Hard Fat
1～3 part of sour magnesium, 0.1～0.3 part of ethyl hydroxybenzoate, 2～5 parts of potassium citrate, 2～5 parts of starch, 0.2～0.6 part of methyl-silicone oil, food
With 1～3 part of pigment, 80～100 parts of purified water.
2. a kind of pectin Capsuleses according to claim 1 it is characterised in that：Described jelly powder degree of gelation>97 degree,
Esterification degree 52-58%, galacturonic acid>85%.
3. a kind of pectin Capsuleses according to claim 2 it is characterised in that：Described Aquacoat with
Cellulose acetate aqueous dispersion is according to 2.5:1.5 ratio is mixed.
4. a kind of pectin Capsuleses according to claim 3 it is characterised in that：Described food coloring adopt natural from
One of the Rhizoma Curcumae Longae of extracting directly, beta-carotene, chlorophyll and Monas cuspurpureus Went or arbitrarily several mixture in plant.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610916954.6A CN106389378A (en) | 2016-10-20 | 2016-10-20 | Pectin hollow capsule |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610916954.6A CN106389378A (en) | 2016-10-20 | 2016-10-20 | Pectin hollow capsule |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106389378A true CN106389378A (en) | 2017-02-15 |
Family
ID=58013251
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610916954.6A Pending CN106389378A (en) | 2016-10-20 | 2016-10-20 | Pectin hollow capsule |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106389378A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110200934A (en) * | 2019-05-20 | 2019-09-06 | 贵阳学院 | It is a kind of using pectin in melon and fruit peel in August as capsule shells of raw material and preparation method thereof |
| CN116283032A (en) * | 2022-07-29 | 2023-06-23 | 顺裕（龙岩）混凝土有限公司 | Preparation process of additive for improving workability of concrete |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104523647A (en) * | 2014-12-15 | 2015-04-22 | 浙江宏辉胶丸有限公司 | Enteric hollow capsule made from pectin |
-
2016
- 2016-10-20 CN CN201610916954.6A patent/CN106389378A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104523647A (en) * | 2014-12-15 | 2015-04-22 | 浙江宏辉胶丸有限公司 | Enteric hollow capsule made from pectin |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110200934A (en) * | 2019-05-20 | 2019-09-06 | 贵阳学院 | It is a kind of using pectin in melon and fruit peel in August as capsule shells of raw material and preparation method thereof |
| CN116283032A (en) * | 2022-07-29 | 2023-06-23 | 顺裕（龙岩）混凝土有限公司 | Preparation process of additive for improving workability of concrete |
| CN116283032B (en) * | 2022-07-29 | 2024-02-27 | 顺裕（龙岩）混凝土有限公司 | Preparation process of additive for improving workability of concrete |
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| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20170215 |
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| RJ01 | Rejection of invention patent application after publication |