CN107854696A - A kind of filming type medical ultrasonic coupling agent and preparation method thereof and application method - Google Patents
A kind of filming type medical ultrasonic coupling agent and preparation method thereof and application method Download PDFInfo
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- CN107854696A CN107854696A CN201711407239.0A CN201711407239A CN107854696A CN 107854696 A CN107854696 A CN 107854696A CN 201711407239 A CN201711407239 A CN 201711407239A CN 107854696 A CN107854696 A CN 107854696A
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- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
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Abstract
The invention discloses a kind of filming type medical ultrasonic coupling agent and preparation method thereof and application method, it is related to medical ultrasonic coupling agent technical field, including 8 15 parts of polyvinyl alcohol, 35 parts of polyethylene glycol, 5 10 parts of sodium alginate, 8 15 parts of carboxymethyl chitosan, 5 10 parts of gelatin, 14 parts of hyaluronic acid, 6 10 parts of Chinese medical concrete, 400 500 parts of deionized water；Wherein, using poplar Chinese holly flower, radix bupleuri, shield-fern, floating fern, grass of meadow rue, Lindley Butterflybush Herb, Grape Skin as raw material, blended extraction obtains Chinese medical concrete.Ultrasonic coupling agent stretchability prepared by the present invention is good, non-stimulated to skin, corrosion-free to ultrasonic probe, the few imaging clearly of bubble, greasy property are superior, and being capable of overall conjunctiva after a period of time is sprayed, film layer can intactly be taken off, and environment temperature is higher, and its conjunctiva time is shorter, take film layer after ultrasonic examination off, it is simple to operate without cleaning, it is easy to use.
Description
Technical field
The present invention relates to medical ultrasonic coupling agent technical field, more particularly to a kind of filming type medical ultrasonic coupling agent and its
Preparation method and application method.
Background technology
When ultrasonic wave incides the interface of two kinds of different mediums, two kinds of medium impedances differences are bigger, and reflectance factor is got over
Greatly, the acoustic energy that another medium is entered through interface is fewer.For medical supersonic, if allowing probe and skin " dry contact ", by
Acted in the strong reflection of air layer therebetween, the launched ultrasonic wave of probe cannot be introduced into human body at all.For that purpose it is necessary to
Certain material is filled between detecting head surface and skin, to drive away air, formation makes ultrasonic wave smooth and the passage of undistorted propagation,
This material is known as medical ultrasonic coupling agent.
Purpose using ultrasonic coupling agent is the slight void between filling probe and skin contact first, excludes these
Influence of the interstitial micro-air to ultrasonic penetration；Next to that by the transitional function of couplant, reduce probe and skin it
Between acoustic impedance difference, so as to reduce reflection loss of the ultrasonic energy at this interface.In addition, also playing lubrication, reduce probe face
Friction between skin, probe is neatly slided and detect.In recent years, to prevent clinical cross-infection, and meet to make
With the gelation condition requirement needed for ultrasound guided puncture, production sterilization, sterilization type coupling gel are all had started to both at home and abroad, makes its tool
There is living tissue biocompatibility and biodegradable, and lubrication property is excellent, can be coated on inside and outside probe or sheath, so as to reach
Entrant sound, lubrication and living tissue bio-compatible, the resultant effect for preventing medical cross infection.However, existing ultrasonic coupling agent
, it is necessary to which carrying out cleaning could remove after ultrasonic examination terminates, it is inconvenient for use to result in its.
The content of the invention
In view of this, it is an object of the invention to provide a kind of filming type medical ultrasonic coupling agent, applying ultrasonic coupling agent
Smear after a period of time can overall conjunctiva, ultrasonic examination only need to take film layer off after terminating, easy to use without cleaning.
The present invention solves above-mentioned technical problem by following technological means：
A kind of filming type medical ultrasonic coupling agent, include the raw material of following parts by weight：
Polyvinyl alcohol 8-15 parts, polyethylene glycol 3-5 parts, sodium alginate 5-10 parts, carboxymethyl chitosan 8-15 parts, gelatin 5-
10 parts, hyaluronic acid 1-4 parts, Chinese medical concrete 6-10 parts, deionized water 400-500 parts；
Wherein, Chinese medical concrete is using poplar Chinese holly flower, radix bupleuri, shield-fern, floating fern, grass of meadow rue, Lindley Butterflybush Herb, Grape Skin as raw material, warp
Mixing extraction obtains.Extracted using poplar Chinese holly flower, radix bupleuri, shield-fern, floating fern, grass of meadow rue, Lindley Butterflybush Herb, Grape Skin as raw material in obtaining
Rich in a variety of anti-inflammations, the traditional Chinese medicine ingredients of blood stasis removing analgesic in medicine medicinal extract, medical ultrasonic coupling agent is set to possess anti-inflammation, dissipate the stasis of blood
The effect of analgesic.
Further, the lower parts by weight for extracting the various Chinese medicines of Chinese medical concrete are as follows：
It is poplar Chinese holly flower 30-60 parts, radix bupleuri 35-60 parts, shield-fern 40-80 parts, floating fern 50-90 parts, grass of meadow rue 40-60 parts, liquor-saturated
Water shield 30-50 parts, Grape Skin 60-90 parts.
Further, the extracting method of Chinese medical concrete is as follows：
After poplar Chinese holly flower, radix bupleuri, shield-fern, floating fern, grass of meadow rue, Lindley Butterflybush Herb, Grape Skin are dried, co-grinding crosses 60 mesh
Sieve, obtain mixed powder, pouch be bundled into by mixed powder and with filter paper, then successively with concentration be 65%, 70%, 75%,
80% ethanol carries out gradient extraction, and Extracting temperature is 65-70 DEG C, and the extraction time of each gradient is 20-40min, Ran Houhe
And the filtrate of each gradient, filtrate decompression distillation and concentration to pulpous state, that is, obtain Chinese medical concrete.
Further, being evaporated under reduced pressure contracting condition is：Prior to 55 DEG C~60 DEG C of temperature, steamed under vacuum 0.06MPa~0.07MPa
Evaporate to without phegma, make ethanol be kept completely separate out, to recycle；Then at prior to 76 DEG C~80 DEG C of temperature, vacuum
Distillation, with evaporating water, obtains the Chinese medical concrete of pulpous state to without phegma under 0.06MPa~0.07MPa.
Further, mixed powder is with ethanol gradient extraction process, mixed powder and the second that concentration is 65% and 70%
Alcohol solid-liquid ratio is 1:4, the ethanol solid-liquid ratio that mixed powder is 75% and 80%% with concentration is 1:2.
In addition, present invention also offers a kind of preparation method of filming type medical ultrasonic coupling agent, comprise the following steps：
1) remove ionized water and be heated to 60 DEG C, then add gelatin, be sufficiently stirred dissolving, obtain gelatin solution；
2) after gelatin solution is cooled to 50 DEG C, carboxymethyl chitosan is slowly added under stirring condition, it is to be mixed uniform
Afterwards, polyvinyl alcohol, polyethylene glycol, sodium alginate, hyaluronic acid are added, is uniformly mixed, obtains complex sol；
3) Chinese medical concrete is taken, complex sol is added under 50 DEG C of stirring conditions, after being well mixed, is cooled down under stirring condition
To room temperature, that is, obtain ultrasonic coupling agent.
A kind of application method of filming type medical ultrasonic coupling agent of the present invention is as follows：
Ultrasonic coupling agent is mixed with deionized water, stirred, obtains ultrasonic coupling agent dilution, ultrasonic coupling agent with
Deionized water mixed proportion is 1:0.5-1:3；
Ultrasonic coupling agent dilution is loaded into spray bottle spraying to use.
More it is convenient to spray after ultrasonic coupling agent is diluted with deionized water, its dilution ratio can be according to environment temperature
Regulation, the deionized water ratio of environment temperature more highly diluted is bigger, to slow down conjunctiva speed, ensures the suitable of this checking process
Profit is completed；Spraying the method used can make couplant scattered more uniformly in skin surface, and ultrasonic coupling agent is smearing one section
Form that film globality is stronger, and thickness is more uniform after time, film layer can be avoided damaged during opening, make entirely to take off film mistake
Journey is more convenient.
Poplar Chinese holly is spent：The hero of Chinese white poplar dries inflorescence, rich in protein, several amino acids, polysaccharide, phosphorus, calcium, flavonoid
Thing and phenols；Wherein, flavone compound is main active material, has obvious antioxidation；Poplar structure spends extract solution
In medicine glycosides content it is higher, there is obvious inhibiting bacteria and diminishing inflammation and antianaphylactic effect.
Radix bupleuri：Umbelliferae Bupleunim. L, radix bupleuri are conventional Chinese medicine, are used as medicine with root, have inducing diaphoresis and it is inner, bring down a fever, rising Yang,
The function of soothing liver-qi stagnation；Also, radix bupleuri has good antipyretic-antalgic and antiinflammation.
Shield-fern：Dryopteridaceae plant has significant antibacterial activity, to staphylococcus aureus, Escherichia coli, typhoid fever bar
Bacterium, Bacillus acidi lactici, fungi and Gram-negative bacteria have different degrees of antibacterial activity.
Floating fern：Floating fern is a kind of untapped wild fern resource, and plant is edible, among the people to have the record being used as medicine,
With sterilize, go to swell, stagnation resolvation, bring down a fever, anti-inflammatory, resistance building and other effects.
Grass of meadow rue：It is bitter, cold in nature, can eliminate scorching pain, the soft contracting of lump, water decoction in vitro to staphylococcus aureus,
Diplococcus pneumopniae, corynebacterium diphtheriae, proteus, shigella flexneri etc. have inhibitory action.
Lindley Butterflybush Herb：Flower and leaf are containing a variety of flavonoids such as buddleo-glucoside, linariin, robinins；Flower, leaf and root hyoscine,
Have the effect of dispelling wind and eliminating dampness, it is relieving cough and reducing sputum, dissipate the stasis of blood.
Grape Skin：Resveratrol is rich in Grape Skin, there is anti-oxidant, antitumor, Green Tea Extract, protection liver, protection
Cardiovascular, immune, the antiviral, antibacterium of regulation and fungi, antiallergic action, radiation protection, prevention acute infective atypia
Pneumonia (SARS) and other effects.
Beneficial effects of the present invention：Ultrasonic coupling agent stretchability prepared by the present invention is good, it is non-stimulated to skin, ultrasound is visited
Corrosion-free, the few imaging clearly of bubble, greasy property are superior, and after a period of time is sprayed can overall conjunctiva, film layer can
Intactly to take off, and its higher conjunctiva time of environment temperature is shorter, takes film layer after ultrasonic examination off, without cleaning,
It is simple to operate, it is easy to use.
Embodiment
Below with reference to embodiment, the present invention is described in detail：
The preparation embodiment one of Chinese medical concrete
The Chinese medical concrete of the present invention, include the Chinese medicine of following parts by weight：
Poplar Chinese holly spend 30 parts, 35 parts of radix bupleuri, 40 parts of shield-fern, 50 parts of floating fern, 40 parts of grass of meadow rue, 30 parts of Lindley Butterflybush Herb, Grape Skin
60 parts.Its preparation method is as follows：
After poplar Chinese holly flower, radix bupleuri, shield-fern, floating fern, grass of meadow rue, Lindley Butterflybush Herb, Grape Skin are dried, co-grinding crosses 60 mesh
Sieve, obtain mixed powder, pouch be bundled into by mixed powder and with filter paper, then successively with concentration be 65%, 70%, 75%,
80% ethanol carries out gradient extraction, wherein, Extracting temperature is 65 DEG C, and extraction time of each gradient is 20min, mixed powder
It is 1 with ethanol solid-liquid ratio that concentration is 65% and 70%:4, mixed powder and concentration are 75% and 80%% ethanol solid-liquid ratio
For 1:2, merge the filtrate of each gradient after the completion of extraction, filtrate prior to 55 DEG C~60 DEG C of temperature, vacuum 0.06MPa~
Distillation is to without phegma under 0.07MPa, then at prior to 76 DEG C~80 DEG C of temperature, distilled under vacuum 0.06MPa~0.07MPa to
Without phegma, that is, obtain Chinese medical concrete.
The preparation embodiment two of Chinese medical concrete
Poplar Chinese holly spend 60 parts, 60 parts of radix bupleuri, 80 parts of shield-fern, 90 parts of floating fern, 60 parts of grass of meadow rue, 50 parts of Lindley Butterflybush Herb, Grape Skin
90 parts.Its preparation method is as follows：
After poplar Chinese holly flower, radix bupleuri, shield-fern, floating fern, grass of meadow rue, Lindley Butterflybush Herb, Grape Skin are dried, co-grinding crosses 60 mesh
Sieve, obtain mixed powder, pouch be bundled into by mixed powder and with filter paper, then successively with concentration be 65%, 70%, 75%,
80% ethanol carries out gradient extraction, wherein, Extracting temperature is 70 DEG C, and extraction time of each gradient is 40min, mixed powder
It is 1 with ethanol solid-liquid ratio that concentration is 65% and 70%:4, mixed powder and concentration are 75% and 80%% ethanol solid-liquid ratio
For 1:2, merge the filtrate of each gradient after the completion of extraction, filtrate prior to 55 DEG C~60 DEG C of temperature, vacuum 0.06MPa~
Distillation is to without phegma under 0.07MPa, then at prior to 76 DEG C~80 DEG C of temperature, distilled under vacuum 0.06MPa~0.07MPa to
Without phegma, that is, obtain Chinese medical concrete.
The preparation embodiment three of Chinese medical concrete
Poplar Chinese holly spend 50 parts, 40 parts of radix bupleuri, 70 parts of shield-fern, 60 parts of floating fern, 50 parts of grass of meadow rue, 40 parts of Lindley Butterflybush Herb, Grape Skin
80 parts.Its preparation method is as follows：
After poplar Chinese holly flower, radix bupleuri, shield-fern, floating fern, grass of meadow rue, Lindley Butterflybush Herb, Grape Skin are dried, co-grinding crosses 60 mesh
Sieve, obtain mixed powder, pouch be bundled into by mixed powder and with filter paper, then successively with concentration be 65%, 70%, 75%,
80% ethanol carries out gradient extraction, wherein, Extracting temperature is 68 DEG C, and extraction time of each gradient is 30min, mixed powder
It is 1 with ethanol solid-liquid ratio that concentration is 65% and 70%:4, mixed powder and concentration are 75% and 80%% ethanol solid-liquid ratio
For 1:2, merge the filtrate of each gradient after the completion of extraction, filtrate prior to 55 DEG C~60 DEG C of temperature, vacuum 0.06MPa~
Distillation is to without phegma under 0.07MPa, then at prior to 76 DEG C~80 DEG C of temperature, distilled under vacuum 0.06MPa~0.07MPa to
Without phegma, that is, obtain Chinese medical concrete.
The preparation example IV of ultrasonic coupling agent
8 parts of polyvinyl alcohol, 3 parts of polyethylene glycol, 5 parts of sodium alginate, 8 parts of carboxymethyl chitosan, 5 parts of gelatin, hyaluronic acid 1
Part, 6 parts of Chinese medical concrete, 400 parts of deionized water.Its preparation method is as follows：
Remove ionized water and be heated to 60 DEG C, then add gelatin, be sufficiently stirred dissolving, obtain gelatin solution；Treat that gelatin is molten
After liquid is cooled to 50 DEG C, be slowly added to carboxymethyl chitosan under stirring condition, it is to be mixed uniformly after, add polyvinyl alcohol, poly-
Ethylene glycol, sodium alginate, hyaluronic acid, are uniformly mixed, and obtain complex sol；Chinese medical concrete is taken, in 50 DEG C of stirring conditions
Lower addition complex sol, after being well mixed, room temperature is cooled under stirring condition, that is, obtains ultrasonic coupling agent.
The preparation embodiment five of ultrasonic coupling agent
It is 15 parts of polyvinyl alcohol, 5 parts of polyethylene glycol, 10 parts of sodium alginate, 15 parts of carboxymethyl chitosan, 10 parts of gelatin, transparent
4 parts of matter acid, 10 parts of Chinese medical concrete, 500 parts of deionized water.Its preparation method is identical with example IV.
The preparation embodiment six of ultrasonic coupling agent
12 parts of polyvinyl alcohol, 4 parts of polyethylene glycol, 7 parts of sodium alginate, 10 parts of carboxymethyl chitosan, 8 parts of gelatin, hyalomitome
3 parts of acid, 8 parts of Chinese medical concrete, 450 parts of deionized water.Its preparation method is identical with example IV.
Take 30 small white mouses to be divided into 3 groups, and numbered with marking pen in root of the tail, 4 × 4cm is cut off then at every mouse back
Hair is as smear zone, and the ultrasonic coupling agent deionized water that example IV to embodiment six is prepared is according to 1:1 ratio
Example is well mixed, then in using spray bottle in the environment of 40 DEG C in the smear zone even application equivalent at every group of small white mouse back
Ultrasonic coupling agent dilution, detect film formation time (min), spraying situation, stimulation situation and the film forming situation of ultrasonic coupling agent, inspection
It is as shown in table 1 to survey result：
Take 30 small white mouses to be divided into 3 groups, 4 × 4cm hairs are cut off as smear zone, Ran Houping then at every mouse back
3 test groups (test group 1, test group 2, test group 3) are divided into, and are numbered with marking pen in root of the tail, be prepared by embodiment six
Obtained ultrasonic coupling agent deionized water is according to 1:1 ratio is well mixed, then with spray bottle at every group of small white mouse back
Smear zone even application equivalent ultrasonic coupling agent dilution, respectively at detecting ultrasonic coupling at 0 DEG C, 10 DEG C, 20 DEG C, 30 DEG C
The film formation time (min) of agent, testing result is as shown in table 2：
From Tables 1 and 2 testing result, ultrasonic coupling agent prepared by example IV to embodiment six sprays on skin
Smoothness, it is uniformly dispersed, and conjunctiva after certain time, the film formed can completely takes off after spray coating after spraying, and to skin
Skin is non-stimulated.The conjunctiva time shortens with the rise of temperature, and in 0 DEG C of environment, its conjunctiva time in 37-40min, works as temperature
When degree reaches 40 DEG C, the conjunctiva time is 15-17min.Therefore, the ultrasonic coupling agent stretchability for preparing of the present invention it is good, to skin without
Stimulation, bubble few imaging clearly corrosion-free to ultrasonic probe, greasy property are superior, and can be whole after a period of time is sprayed
Body conjunctiva, film layer can intactly be taken off, and its higher conjunctiva time of environment temperature is shorter, takes film layer after ultrasonic examination off i.e.
Can, it is simple to operate without cleaning, it is easy to use.
The above embodiments are merely illustrative of the technical solutions of the present invention and it is unrestricted, although with reference to preferred embodiment to this hair
It is bright to be described in detail, it will be understood by those within the art that, technical scheme can be modified
Or equivalent substitution, without departing from the objective and scope of technical solution of the present invention, it all should cover the claim in the present invention
Among scope.The present invention be not described in detail technology, shape, construction part be known technology.
Claims (7)
1. a kind of filming type medical ultrasonic coupling agent, it is characterised in that include the raw material of following parts by weight：
Polyvinyl alcohol 8-15 parts, polyethylene glycol 3-5 parts, sodium alginate 5-10 parts, carboxymethyl chitosan 8-15 parts, gelatin 5-10
Part, hyaluronic acid 1-4 parts, Chinese medical concrete 6-10 parts, deionized water 400-500 parts；
Wherein, the Chinese medical concrete is using poplar Chinese holly flower, radix bupleuri, shield-fern, floating fern, grass of meadow rue, Lindley Butterflybush Herb, Grape Skin as raw material, warp
Mixing extraction obtains.
2. a kind of filming type medical ultrasonic coupling agent according to claim 1, it is characterised in that extract the Chinese medical concrete
Various Chinese medicines lower parts by weight it is as follows：
Poplar Chinese holly flower 30-60 parts, radix bupleuri 35-60 parts, shield-fern 40-80 parts, floating fern 50-90 parts, grass of meadow rue 40-60 parts, Lindley Butterflybush Herb
30-50 parts, Grape Skin 60-90 parts.
3. a kind of filming type medical ultrasonic coupling agent according to claim 2, it is characterised in that the Chinese medical concrete carries
Take method as follows：
After poplar Chinese holly flower, radix bupleuri, shield-fern, floating fern, grass of meadow rue, Lindley Butterflybush Herb, Grape Skin are dried, co-grinding crosses 60 mesh sieves, obtains
To mixed powder, pouch is bundled into by mixed powder and with filter paper, then successively with the second that concentration is 65%, 70%, 75%, 80%
Alcohol carries out gradient extraction, and Extracting temperature is 65-70 DEG C, and the extraction time of each gradient is 20-40min, is then combined with each ladder
The filtrate of degree, filtrate decompression distillation and concentration to pulpous state, that is, obtain Chinese medical concrete.
A kind of 4. filming type medical ultrasonic coupling agent according to claim 3, it is characterised in that the vacuum distillation contracting bar
Part is：Prior to 55 DEG C~60 DEG C of temperature, distilled extremely without phegma under vacuum 0.06MPa~0.07MPa, then at prior to temperature 76
DEG C~80 DEG C, distillation is to without phegma under vacuum 0.06MPa~0.07MPa.
5. a kind of filming type medical ultrasonic coupling agent according to claim 4, it is characterised in that mixed powder is with ethanol
In gradient extraction process, the ethanol solid-liquid ratio that mixed powder is 65% and 70% with concentration is 1:4, mixed powder is with concentration
75% and 80%% ethanol solid-liquid ratio is 1:2.
A kind of 6. preparation method of filming type medical ultrasonic coupling agent as claimed in claim 1 or 2, it is characterised in that including
Following steps：
1) remove ionized water and be heated to 60 DEG C, then add gelatin, be sufficiently stirred dissolving, obtain gelatin solution；
2) after gelatin solution is cooled to 50 DEG C, be slowly added to carboxymethyl chitosan under stirring condition, it is to be mixed uniformly after, add
Enter polyvinyl alcohol, polyethylene glycol, sodium alginate, hyaluronic acid, be uniformly mixed, obtain complex sol；
3) Chinese medical concrete is taken, complex sol is added under 50 DEG C of stirring conditions, after being well mixed, room is cooled under stirring condition
Temperature, that is, obtain ultrasonic coupling agent.
A kind of 7. application method of filming type medical ultrasonic coupling agent as claimed in claim 6, it is characterised in that the user
The step of method, includes：
Ultrasonic coupling agent is mixed with deionized water, stirred, obtains ultrasonic coupling agent dilution, ultrasonic coupling agent and go from
Sub- water mixed proportion is 1:0.5-1:3；
Ultrasonic coupling agent dilution is loaded into spray bottle spraying to use.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109613125A (en) * | 2019-01-22 | 2019-04-12 | 中国地质大学（北京） | It is a kind of for detecting the couplant of masonry historical relic ultrasonic property |
| CN116549675A (en) * | 2023-05-10 | 2023-08-08 | 苏州大学附属儿童医院 | Non-irritating medical ultrasonic coupling agent and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102188723A (en) * | 2011-04-22 | 2011-09-21 | 北京道行中孚科技有限公司 | Cleaning-free medical ultrasonic couplant, and preparation method thereof |
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2017
- 2017-12-22 CN CN201711407239.0A patent/CN107854696B/en active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102188723A (en) * | 2011-04-22 | 2011-09-21 | 北京道行中孚科技有限公司 | Cleaning-free medical ultrasonic couplant, and preparation method thereof |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109613125A (en) * | 2019-01-22 | 2019-04-12 | 中国地质大学（北京） | It is a kind of for detecting the couplant of masonry historical relic ultrasonic property |
| CN116549675A (en) * | 2023-05-10 | 2023-08-08 | 苏州大学附属儿童医院 | Non-irritating medical ultrasonic coupling agent and preparation method thereof |
| CN116549675B (en) * | 2023-05-10 | 2024-01-23 | 苏州大学附属儿童医院 | Non-irritating medical ultrasonic coupling agent and preparation method thereof |
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