CN101485643A - Plant hollow capsule - Google Patents
Plant hollow capsule Download PDFInfo
- Publication number
- CN101485643A CN101485643A CNA2009101162426A CN200910116242A CN101485643A CN 101485643 A CN101485643 A CN 101485643A CN A2009101162426 A CNA2009101162426 A CN A2009101162426A CN 200910116242 A CN200910116242 A CN 200910116242A CN 101485643 A CN101485643 A CN 101485643A
- Authority
- CN
- China
- Prior art keywords
- capsule
- hollow capsule
- glue
- capsules
- gum
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Jellies, Jams, And Syrups (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention provides a vegetable hollow capsule, which is prepared by taking cellulose ether as a raw material. The hollow capsule is characterized by comprising the following components in percentage by weight: 80 to 90 percent of carboxymethyl cellulose, 1.5 to 10 percent of curing agent and 1.5 to 10 percent of coagulant aid, wherein the curing agent is selected from one or mixed glue of more than two of vegetable glue, or microbial glue or seaweed glue; and the coagulant aid is selected from potassium citrate or sodium citrate and the like. Just like the gelatin hollow capsule, the preparation of the vegetable hollow capsule also comprises the preparation of glue materials and the processing of capsule shell, and the processing equipment of the gelatin hollow capsule is also used. The capsule has the advantages of bright surface gloss, good fluency, and high rate of capsule filling; moreover, the indexes such as disintegration time limit, friability at different temperatures and the like, meet national standards of the gelatin hollow capsule.
Description
One, technical field
The present invention relates to the adjuvant that a kind of pharmaceutical preparation is used, specifically a kind of plant hollow capsule with carboxymethyl cellulose processing.
Two, background technology
Capsules is the main adjuvant of processing medicament capsule preparation.The Capsules that uses is processed by gelatin mostly at present.Glue after gelatin elder generation water logging bubble, the swelling, after send the capsule manufacture line to obtain Capsules (softgel shell) through dipping in operations such as gum forming, dry solidification, cooling, cutting.Described glue is exactly the gelatin after the swelling to be dropped in the mixing kettle to heat up with water, surfactant etc. stir, after filtration, remove bubble, obtain sizing material after transferring proportion.
The water soluble protein that gelatin is obtained through hydrolysis by the collagen protein in the connective tissues such as the skin of animal, bone, tendon, ligament.Protein is subject to the influence of acid, alkali, and medicated powder acidity or alkalescence that Ruo Qinei fills are stronger, and practice shows, in storage process, although also in the shelf-life, the quality of capsule also seriously descends, such as sclerosis, embrittlement, easy disintegrating not, serious only remaining a pile powder.In addition, because of the religions belief reason, take as taboos such as Islam, kosher; In recent years epidemic situations such as " bovine spongiform encephalopathy " of Chu Xianing, " foot and mouth disease " again serious impact gelatine capsule agent market.Other feedstock production capsules that exploitation substitutes gelatin have realistic meaning.So have human hydroxypropyl emthylcellulose (HPMC) and polysaccharide to prepare Capsules.But more capsular physicochemical properties of this class such as low temperature friability, not anti-temperature storage etc. still can not be satisfactory more than 30 ℃.
Gelatin is taken from animal, and cellulose ether and polysaccharide for being different from the gelatin Capsules, claim that the Capsules with cellulose ether and polysaccharide processing is a plant hollow capsule from plant.
Three, summary of the invention
The present invention aims to provide the new plant hollow capsule that a kind of every physicochemical property all meets the pharmacopeia regulation, and technical problem to be solved is to select suitable cellulose ether composition.
Cellulose ether is be raw material with the native cellulose through chemistry change a social system the class molding high molecular weight water soluble polymer that narrows, principal item has ion-type such as carboxymethyl cellulose, sulfonic acid ethyl cellulose and nonionic such as methylcellulose (CM), hydroxyethyl-cellulose (HEC) etc.The applicant is through the condition test of system, and choosing carboxymethyl cellulose (CMC) in the cellulose ether series of products is raw material, and is aided with firming agent and flocculation aid processing plant hollow capsule, and each component has following percentage by weight:
CMC:80～96%, firming agent: 1.5～10%, flocculation aid: 1.5～10%.
Described firming agent is selected from plant gum, as arabic gum or sesbania gum or carrageenan or pectin, and perhaps microbiological gum, as gellan gum or xanthan gum, perhaps one or more epoxy glues in alginate jelly or the agar etc.Preferred carrageenan is or/and arabic gum or/and xanthan gum etc.
Described flocculation aid is selected from potassium citrate or sodium citrate or potassium chloride or calcium chloride.Optimization citric acid acid potassium.
CMC is commonly used to be the anionic cellulose ether for sodium salt, is generated by alkali fiber (native cellulose and finite concentration NaOH solution effects generate) and the reaction of etherifying agent sodium chloroacetate.Can obtain the CMC of different molecular weight in preparation process, the molecular weight difference only influences the viscosity of CMC solution, and experiment shows that the CMC of different molecular weight all can be used to prepare Capsules.
CMC, firming agent and flocculation aid are the key components of this plant hollow capsule, and be the same with processing gelatin Capsules in addition, also can add food coloring according to actual needs or/and opacifier titanium dioxide etc.
The preparation of this Capsules also comprises the preparation of sizing material and the processing of softgel shell.Will CMC and water drop into that heated and stirred dissolving back adds firming agent and flocculation aid in the mixing kettle, the after-filtration that stirs, remove bubble, transfer proportion (being CMC concentration), send capsule manufacture line processing softgel shell then.
This Capsules appearance surfaces is glossy, and fluency is good, probability height on the capsule shells filling medicated powder, and the user uses percent defective low.And HPMC plant hollow capsule and polysaccharide vegetable Capsules appearance surfaces are lackluster, and fluency is poor, and probability is low on the capsule shells filling medicated powder, the percent defective height, and particularly HPMC plant hollow capsule surface is poorer.
" 2 000 editions regulation Capsuleses of Chinese pharmacopoeia disintegration time is 10 minutes, and this capsule only needs 6 minutes, and other two plant capsules generally all need 10-15 minute.
Insulation is 4 hours under the different temperatures.Observe the viscosity degradation percentage rate, comparative test the results are shown in Table 1.
Table 1:
| 45℃ | 50℃—60℃ | 70℃—80℃ | |
| The CMC plant hollow capsule | 0 | 0 | 1％ |
| Capsules | Expand and do not dissolve | 2％ | 5％ |
| The HPMC plant hollow capsule | 0 | 8％ | 100％ |
| The polysaccharide vegetable Capsules | 0 | 10％ | 25％ |
The leftover bits and pieces or the waste product that produce in this explanation CMC production process, quality does not descend, can reclaim use repeatedly again, product cost is just low, and other three kinds recovery service property (quality)s are poor, the leftover bits and pieces or the waste product that resemble the HPMC plant hollow capsule just can not reclaim, and this has just improved the cost of product undoubtedly.
Under the different temperatures, preserved three months, comparative test the results are shown in Table 2.
Table 2:
Friability is by " 2 00 editions two Capsules standard operations of Chinese pharmacopoeia, 50 capsules detect with 20 gram counterweights, crisp broken capsule does not allow to exceed 15, from these four kinds of capsules of result 15--25 ℃ can both be qualified, but CMC plant hollow capsule advantage is more obvious under low temperature and hot conditions.And Capsules is in that " Chinese pharmacopoeia 2 000 editions is clear and definite regulation just, must store (below 20 ℃) in the cool, and this illustrates that the capsule of other two kinds requires relatively harshness on temperature.
Four, the specific embodiment
Below the present invention is described in further detail, and provide the specific embodiment.
Embodiment 1, get low viscosity CMC30kg, carrageenan 3kg, potassium citrate 3kg, water 64kg.
Production equipment is identical with former useful manufacturing of gelatin Capsules.Pour CMC and water into the reaction pot heated and stirred, dissolving, add firming agent and flocculation aid again, 60 ℃-90 ℃ of the recirculated water water temperatures of reaction pot, stirred 2-4 hours, fully glue is filtered with 200 purpose filter bags in the dissolving back, glue is stored in the heat-preserving container, see proportion, regulate gelatin concentration, different institutes add versicolor food coloring and add a certain amount of opacifier titanium dioxide etc. according to user's demand, leave standstill insulation again except that bubble, put into again on the capsule manufacture line through dipping in glue, oven dry, cooling, the demoulding, cutting, fit, check, packing needs lettering lettering etc. behind fit.
Embodiment 2, get medium viscosity (FM
6) CMC25kg, arabic gum 1.5kg, carrageenan 1kg, potassium citrate 2.5kg, water 70kg.Also can be according to user's demand difference with adding versicolor food coloring and a certain amount of opacifier titanium dioxide etc.Its production method is with embodiment 1.
Embodiment 3, get high viscosity (FH
6) CMC20kg, xanthan gum 1.5kg, carrageenan 0.5kg, potassium citrate 2kg, water 76kg.Also can be according to user's demand difference adds versicolor food coloring and a certain amount of opacifier titanium dioxide etc.Its production method is with embodiment 1.
Embodiment 4, get extra-high-speed viscosity CMC15kg, carrageenan 1.5kg, potassium citrate 1.5kg, water 82kg also can add versicolor food coloring and a certain amount of opacifier titanium dioxide etc. according to user's demand difference.Its production method is with embodiment 1.
Claims (5)
1, a kind of plant hollow capsule is to be the Capsules of feedstock production by cellulose ether, and it is characterized in that: each component has following percentage by weight: carboxymethyl cellulose 80～90%, firming agent 1.5～10%, flocculation aid 1.5～10%.
2, Capsules according to claim 1 is characterized in that: described firming agent is selected from one or more epoxy glues in arabic gum or sesbania gum or carrageenan or pectin or gellan gum or xanthan gum or alginate jelly or the agar.
3, Capsules according to claim 2 is characterized in that: described firming agent be selected from carrageenan or/and arabic gum or/and xanthan gum.
4, Capsules according to claim 1 and 2 is characterized in that: described flocculation aid is selected from potassium citrate or citric acid sodium or potassium chloride or calcium chloride.
5, Capsules according to claim 4 is characterized in that: described flocculation aid is selected from potassium citrate.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009101162426A CN101485643B (en) | 2009-02-25 | 2009-02-25 | Plant hollow capsule |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009101162426A CN101485643B (en) | 2009-02-25 | 2009-02-25 | Plant hollow capsule |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101485643A true CN101485643A (en) | 2009-07-22 |
| CN101485643B CN101485643B (en) | 2012-01-11 |
Family
ID=40888806
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2009101162426A Active CN101485643B (en) | 2009-02-25 | 2009-02-25 | Plant hollow capsule |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN101485643B (en) |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103861114A (en) * | 2014-03-13 | 2014-06-18 | 中国科学院化学研究所 | Functional vegetated substrate hollow capsule |
| CN104000798A (en) * | 2014-06-11 | 2014-08-27 | 青岛双鲸药业有限公司 | Vegetative soft capsule |
| CN106377516A (en) * | 2016-08-30 | 2017-02-08 | 浙江宏辉胶丸有限公司 | Tea plant hollow hard capsule and preparation method and application thereof |
| CN107233329A (en) * | 2017-05-12 | 2017-10-10 | 安徽黄山胶囊股份有限公司 | A kind of instant Capsules and preparation method thereof |
| CN109288809A (en) * | 2018-11-04 | 2019-02-01 | 李国桐 | A kind of compound material preparing medicinal plant capsule |
| CN109528689A (en) * | 2018-12-24 | 2019-03-29 | 江苏辰星药业股份有限公司 | A kind of enteric slow release plant capsule and preparation method thereof |
| CN109528676A (en) * | 2018-12-24 | 2019-03-29 | 江苏辰星药业股份有限公司 | A kind of seaweed polysaccharide plant soft capsule and preparation method thereof |
| CN113018275A (en) * | 2021-03-11 | 2021-06-25 | 安徽黄山胶囊股份有限公司 | Povidone empty capsule and production process thereof |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101167705B (en) * | 2007-11-13 | 2010-08-18 | 北京长征天民高科技有限公司 | Composition for preparing plant hollow hard capsule and preparation method of capsule |
-
2009
- 2009-02-25 CN CN2009101162426A patent/CN101485643B/en active Active
Cited By (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103861114A (en) * | 2014-03-13 | 2014-06-18 | 中国科学院化学研究所 | Functional vegetated substrate hollow capsule |
| CN104000798A (en) * | 2014-06-11 | 2014-08-27 | 青岛双鲸药业有限公司 | Vegetative soft capsule |
| CN104000798B (en) * | 2014-06-11 | 2016-02-03 | 青岛双鲸药业有限公司 | A kind of autonomic soft capsules |
| CN106377516A (en) * | 2016-08-30 | 2017-02-08 | 浙江宏辉胶丸有限公司 | Tea plant hollow hard capsule and preparation method and application thereof |
| CN107233329B (en) * | 2017-05-12 | 2020-04-21 | 安徽黄山胶囊股份有限公司 | Instant hollow capsule and preparation method thereof |
| CN107233329A (en) * | 2017-05-12 | 2017-10-10 | 安徽黄山胶囊股份有限公司 | A kind of instant Capsules and preparation method thereof |
| CN109288809B (en) * | 2018-11-04 | 2021-06-01 | 李国桐 | Composite raw material for preparing medicinal plant capsule |
| CN109288809A (en) * | 2018-11-04 | 2019-02-01 | 李国桐 | A kind of compound material preparing medicinal plant capsule |
| CN109528676A (en) * | 2018-12-24 | 2019-03-29 | 江苏辰星药业股份有限公司 | A kind of seaweed polysaccharide plant soft capsule and preparation method thereof |
| CN109528689A (en) * | 2018-12-24 | 2019-03-29 | 江苏辰星药业股份有限公司 | A kind of enteric slow release plant capsule and preparation method thereof |
| CN109528689B (en) * | 2018-12-24 | 2021-09-21 | 江苏辰星药业股份有限公司 | Enteric slow-release plant capsule and preparation method thereof |
| CN113018275A (en) * | 2021-03-11 | 2021-06-25 | 安徽黄山胶囊股份有限公司 | Povidone empty capsule and production process thereof |
| CN113018275B (en) * | 2021-03-11 | 2023-02-14 | 安徽黄山胶囊股份有限公司 | Povidone empty capsule and production process thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN101485643B (en) | 2012-01-11 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101485643B (en) | Plant hollow capsule | |
| CN103893772B (en) | A kind of hydroxypropyl starch Capsules and preparation technology thereof | |
| CN103893771B (en) | A kind of film-forming composition for the production of starch material soft capsule and preparation method thereof | |
| EP1117736B2 (en) | Modified starch film compositions | |
| CN102525995B (en) | Plant officinal hollow capsule and preparation method thereof | |
| CN105709234A (en) | Oxidized hydroxypropyl starch empty capsules and preparation process thereof | |
| WO2007122465A2 (en) | Process for manufacturing films | |
| JP2003505565A (en) | Pullulan membrane composition | |
| CN102805871B (en) | Material of soybean polysaccharide hollow capsule and production method of capsule | |
| CN102772386B (en) | Plant capsule compound adhesive and preparation method thereof | |
| CN104436204A (en) | Pullulan polysaccharide capsule and preparation process thereof | |
| CN101708171B (en) | Enteric plant hollow capsule | |
| CN109908103B (en) | Composition for preparing plant soft capsules | |
| CN104840447A (en) | Preparation method of pulullan vacant capsules | |
| CN105878208B (en) | A kind of starch base plant medicinal hard capsule forming agent and its application | |
| CN113768137A (en) | Starch film-forming composition and method for preparing capsule shell by using same | |
| CN104784148B (en) | A kind of film-forming composition for preparing plant capsule and preparation method thereof | |
| EP1072633A1 (en) | Pullulan film compositions | |
| CN106265592A (en) | Hypromellose empty hard capsule and preparation method thereof | |
| CN105456226A (en) | Hydroxypropyl methyl cellulose/hydroxypropyl starch plant empty capsule and preparation method | |
| CN106902093A (en) | A kind of plant enteric hollow capsule and its production method | |
| CN102343093B (en) | Seaweed polysaccharide medicinal plant film coating and preparation method thereof | |
| CN106279789B (en) | It is used to prepare the composite modified starch and preparation method of Capsules | |
| CN104224747A (en) | Algae-based gastric pH response disintegrative empty capsule and preparation method thereof | |
| CN104387476B (en) | The preparation method of food-class high-purity viscosity higher sodium carboxymethyl cellulose |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| ASS | Succession or assignment of patent right |
Owner name: ANHUI HUANGSHAN CAPSULE CO., LTD. Free format text: FORMER OWNER: LIU SONGLIN Effective date: 20121217 |
|
| C41 | Transfer of patent application or patent right or utility model | ||
| COR | Change of bibliographic data |
Free format text: CORRECT: ADDRESS; FROM: 242600 XUANCHENG, ANHUI PROVINCE TO: 242605 XUANCHENG, ANHUI PROVINCE |
|
| TR01 | Transfer of patent right |
Effective date of registration: 20121217 Address after: 242605 Anhui, Xuancheng County, Jingde Province, Hong Chuan Patentee after: Anhui Huangshan Capsule Co.,Ltd. Address before: 242600 Anhui County of Jingde province Jingyang town Liang Jia No. 5 Patentee before: Liu Songlin |