CN106377516A - Tea plant hollow hard capsule and preparation method and application thereof - Google Patents
Tea plant hollow hard capsule and preparation method and application thereof Download PDFInfo
- Publication number
- CN106377516A CN106377516A CN201610780487.9A CN201610780487A CN106377516A CN 106377516 A CN106377516 A CN 106377516A CN 201610780487 A CN201610780487 A CN 201610780487A CN 106377516 A CN106377516 A CN 106377516A
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- Prior art keywords
- tea
- capsule
- hard capsule
- carboxymethyl cellulose
- glue
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- 244000269722 Thea sinensis Species 0.000 title claims abstract description 72
- 239000007902 hard capsule Substances 0.000 title claims abstract description 29
- 235000006468 Thea sinensis Nutrition 0.000 title claims abstract description 24
- 238000002360 preparation method Methods 0.000 title claims abstract description 21
- 229920002134 Carboxymethyl cellulose Polymers 0.000 claims abstract description 28
- 239000000835 fiber Substances 0.000 claims abstract description 19
- 229920001817 Agar Polymers 0.000 claims abstract description 15
- 239000008272 agar Substances 0.000 claims abstract description 15
- 235000010419 agar Nutrition 0.000 claims abstract description 15
- 235000010418 carrageenan Nutrition 0.000 claims abstract description 13
- 239000000679 carrageenan Substances 0.000 claims abstract description 13
- 229920001525 carrageenan Polymers 0.000 claims abstract description 13
- 229940113118 carrageenan Drugs 0.000 claims abstract description 13
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 claims abstract description 13
- 239000003814 drug Substances 0.000 claims abstract description 8
- 239000004014 plasticizer Substances 0.000 claims abstract description 7
- 238000012545 processing Methods 0.000 claims abstract description 4
- 239000002775 capsule Substances 0.000 claims description 44
- 239000000243 solution Substances 0.000 claims description 44
- 239000003292 glue Substances 0.000 claims description 30
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 24
- 239000001768 carboxy methyl cellulose Substances 0.000 claims description 22
- 235000010948 carboxy methyl cellulose Nutrition 0.000 claims description 22
- 239000008112 carboxymethyl-cellulose Substances 0.000 claims description 22
- 239000007788 liquid Substances 0.000 claims description 22
- 239000000284 extract Substances 0.000 claims description 13
- 239000000047 product Substances 0.000 claims description 13
- 238000003756 stirring Methods 0.000 claims description 13
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 12
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 11
- 238000000605 extraction Methods 0.000 claims description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 9
- 238000001914 filtration Methods 0.000 claims description 8
- 239000002671 adjuvant Substances 0.000 claims description 7
- 238000001035 drying Methods 0.000 claims description 7
- 230000036541 health Effects 0.000 claims description 7
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims description 6
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 6
- PEDCQBHIVMGVHV-UHFFFAOYSA-N glycerol group Chemical group OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 6
- 230000007935 neutral effect Effects 0.000 claims description 6
- 238000006243 chemical reaction Methods 0.000 claims description 5
- DATAGRPVKZEWHA-YFKPBYRVSA-N N(5)-ethyl-L-glutamine Chemical compound CCNC(=O)CC[C@H]([NH3+])C([O-])=O DATAGRPVKZEWHA-YFKPBYRVSA-N 0.000 claims description 4
- 229920002565 Polyethylene Glycol 400 Polymers 0.000 claims description 4
- 239000007864 aqueous solution Substances 0.000 claims description 4
- 238000006266 etherification reaction Methods 0.000 claims description 4
- 235000013305 food Nutrition 0.000 claims description 4
- 238000007602 hot air drying Methods 0.000 claims description 4
- 230000004048 modification Effects 0.000 claims description 4
- 238000012986 modification Methods 0.000 claims description 4
- JLFNLZLINWHATN-UHFFFAOYSA-N pentaethylene glycol Chemical compound OCCOCCOCCOCCOCCO JLFNLZLINWHATN-UHFFFAOYSA-N 0.000 claims description 4
- 229960000583 acetic acid Drugs 0.000 claims description 3
- 239000012295 chemical reaction liquid Substances 0.000 claims description 3
- 238000004140 cleaning Methods 0.000 claims description 3
- 238000005520 cutting process Methods 0.000 claims description 3
- 230000006837 decompression Effects 0.000 claims description 3
- 238000007598 dipping method Methods 0.000 claims description 3
- 239000012362 glacial acetic acid Substances 0.000 claims description 3
- 238000003306 harvesting Methods 0.000 claims description 3
- 239000012535 impurity Substances 0.000 claims description 3
- 238000005461 lubrication Methods 0.000 claims description 3
- 238000006386 neutralization reaction Methods 0.000 claims description 3
- FDRCDNZGSXJAFP-UHFFFAOYSA-M sodium chloroacetate Chemical compound [Na+].[O-]C(=O)CCl FDRCDNZGSXJAFP-UHFFFAOYSA-M 0.000 claims description 3
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims description 2
- 229930195725 Mannitol Natural products 0.000 claims description 2
- 229930013930 alkaloid Natural products 0.000 claims description 2
- 150000003797 alkaloid derivatives Chemical class 0.000 claims description 2
- 125000002057 carboxymethyl group Chemical group [H]OC(=O)C([H])([H])[*] 0.000 claims description 2
- 239000003795 chemical substances by application Substances 0.000 claims description 2
- 238000013329 compounding Methods 0.000 claims description 2
- 239000000706 filtrate Substances 0.000 claims description 2
- 239000000594 mannitol Substances 0.000 claims description 2
- 235000010355 mannitol Nutrition 0.000 claims description 2
- 239000000049 pigment Substances 0.000 claims description 2
- 150000008442 polyphenolic compounds Chemical class 0.000 claims description 2
- 235000013824 polyphenols Nutrition 0.000 claims description 2
- 229940026510 theanine Drugs 0.000 claims description 2
- 239000011782 vitamin Substances 0.000 claims description 2
- 229940088594 vitamin Drugs 0.000 claims description 2
- 229930003231 vitamin Natural products 0.000 claims description 2
- 235000013343 vitamin Nutrition 0.000 claims description 2
- 150000003722 vitamin derivatives Chemical class 0.000 claims description 2
- 241000220324 Pyrus Species 0.000 claims 1
- 235000021017 pears Nutrition 0.000 claims 1
- 238000001935 peptisation Methods 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 abstract description 8
- 239000002994 raw material Substances 0.000 abstract description 8
- 230000004071 biological effect Effects 0.000 abstract description 2
- 229940079593 drug Drugs 0.000 abstract description 2
- 239000003344 environmental pollutant Substances 0.000 abstract description 2
- 239000007903 gelatin capsule Substances 0.000 abstract description 2
- 239000004615 ingredient Substances 0.000 abstract description 2
- 231100000719 pollutant Toxicity 0.000 abstract description 2
- 238000009776 industrial production Methods 0.000 abstract 1
- 238000002386 leaching Methods 0.000 abstract 1
- 238000003754 machining Methods 0.000 abstract 1
- 230000000144 pharmacologic effect Effects 0.000 abstract 1
- 241000196324 Embryophyta Species 0.000 description 13
- 238000005516 engineering process Methods 0.000 description 12
- 229920000159 gelatin Polymers 0.000 description 7
- 235000019322 gelatine Nutrition 0.000 description 7
- 239000001828 Gelatine Substances 0.000 description 5
- 229920002148 Gellan gum Polymers 0.000 description 5
- 235000010492 gellan gum Nutrition 0.000 description 5
- 239000000216 gellan gum Substances 0.000 description 5
- 239000000463 material Substances 0.000 description 5
- 239000000126 substance Substances 0.000 description 5
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical group CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 description 4
- 238000009413 insulation Methods 0.000 description 4
- 108010059892 Cellulase Proteins 0.000 description 3
- 230000008901 benefit Effects 0.000 description 3
- 229940106157 cellulase Drugs 0.000 description 3
- 229920002678 cellulose Polymers 0.000 description 3
- 239000001913 cellulose Substances 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- -1 hydroxypropyl methyl Chemical group 0.000 description 3
- 229920000609 methyl cellulose Polymers 0.000 description 3
- 239000001923 methylcellulose Substances 0.000 description 3
- 235000010981 methylcellulose Nutrition 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 235000010413 sodium alginate Nutrition 0.000 description 3
- 239000000661 sodium alginate Substances 0.000 description 3
- 229940005550 sodium alginate Drugs 0.000 description 3
- 108010010803 Gelatin Proteins 0.000 description 2
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 2
- 239000002131 composite material Substances 0.000 description 2
- 238000011049 filling Methods 0.000 description 2
- 239000008273 gelatin Substances 0.000 description 2
- 235000011852 gelatine desserts Nutrition 0.000 description 2
- 150000004676 glycans Chemical class 0.000 description 2
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 description 2
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 2
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 2
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 description 2
- 229910052751 metal Inorganic materials 0.000 description 2
- 239000002184 metal Substances 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 229920001282 polysaccharide Polymers 0.000 description 2
- 239000005017 polysaccharide Substances 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 238000007873 sieving Methods 0.000 description 2
- 239000002893 slag Substances 0.000 description 2
- 230000002195 synergetic effect Effects 0.000 description 2
- 238000005406 washing Methods 0.000 description 2
- QCVGEOXPDFCNHA-UHFFFAOYSA-N 5,5-dimethyl-2,4-dioxo-1,3-oxazolidine-3-carboxamide Chemical compound CC1(C)OC(=O)N(C(N)=O)C1=O QCVGEOXPDFCNHA-UHFFFAOYSA-N 0.000 description 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
- 102000002322 Egg Proteins Human genes 0.000 description 1
- 108010000912 Egg Proteins Proteins 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 108010059820 Polygalacturonase Proteins 0.000 description 1
- 241000195474 Sargassum Species 0.000 description 1
- 241000238370 Sepia Species 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000002421 anti-septic effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 239000007963 capsule composition Substances 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 239000007795 chemical reaction product Substances 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 238000004132 cross linking Methods 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 230000003292 diminished effect Effects 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 235000014103 egg white Nutrition 0.000 description 1
- 210000000969 egg white Anatomy 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 235000013376 functional food Nutrition 0.000 description 1
- 238000007306 functionalization reaction Methods 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 230000007062 hydrolysis Effects 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- 239000007943 implant Substances 0.000 description 1
- 238000009434 installation Methods 0.000 description 1
- 239000010977 jade Substances 0.000 description 1
- 238000011031 large-scale manufacturing process Methods 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 230000000050 nutritive effect Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 238000003672 processing method Methods 0.000 description 1
- 238000010298 pulverizing process Methods 0.000 description 1
- 238000005956 quaternization reaction Methods 0.000 description 1
- 230000001932 seasonal effect Effects 0.000 description 1
- 238000007493 shaping process Methods 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 229940126680 traditional chinese medicines Drugs 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4816—Wall or shell material
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Jellies, Jams, And Syrups (AREA)
- General Preparation And Processing Of Foods (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention discloses a tea plant hollow hard capsule and a preparation method and application thereof. The tea plant hollow hard capsule is prepared from the following ingredients (by weight): 50-70% of tea leaching liquor, 15-35% of modified tea fiber, 7.5-12.0% of carboxymethyl cellulose (CMC), 0-5% of carrageenan, 0-8% of agar and 0.3-1.5% of a plasticizer. The product has a certain pharmacological activity and health-care function, and biological effect of the content drug is further enhanced. Processing can be carried out with existing gelatin capsule equipment without greatly changing original machining process and technological parameters, utilization rate of equipment is raised, and production cost is remarkably reduced. The raw materials are easily available, and cost is low. There is basically no discharge of pollutants during the production process. According to the invention, industrial production is easy to realize.
Description
【Technical field】
The invention belongs to the technical field of capsule, it is related to a kind of preparation method of plant capsule and in particular to one kind is with tea
Leaf is high healthcare plant empty hard capsule of base stock and preparation method thereof.
【Background technology】
Capsule is one of current Good and the most basic dosage form of functional food, as the excellent carrier of medicine filling,
It has been widely used in multiple industry such as pharmacy, food, cosmetics and household supplies, chemical industry.At present, domestic the overwhelming majority enterprise with
Gelatin is as the primary raw material of Capsuleses.Preparing capsule with gelatin for raw material can bring some inevitable to end product
Negative effect, such as pollution risk is high, poor chemical stability, and market scope is little etc..
After especially there is " toxic capsule " event in recent years, market needs a kind of safe and reliable, green natural, consumer groups badly
Extensively, abundant raw material, capsule product with low cost.And plant type safety capsule is acknowledged as optimal gelatine capsule and substitutes product
Product.Plant type capsule is not only able to largely make up the quality problems of gelatine capsule and wide material sources, stable in properties
And antiseptic property is high.
Chemical composition in Folium Camelliae sinensis is rich and varied, pharmacologically active is high, and contains substantial amounts of biological element, has very high battalion
Support and be worth and health care.When Summer-autumn tea resource faces seasonal surplus, the low problem of added value of product, by the tea in Folium Camelliae sinensis
The effective ingredient such as polysaccharide, tea albumen as the natural origin of capsule capsule material, not only can be of high nutritive value, health care strong
Novel capsule product, also provide green natural for capsule industry, raw material with low cost simultaneously.
The research of domestic plant capsule is ripe not enough at present, though the report being related to plant type capsule product mostly stops
Stay the exploratory experiment stage, fail to accomplish scale production.Abroad have the appearance of non-gelatin capsules material and products thereof, but
It is relatively costly compared with traditional gelatine capsule, lacks the market competitiveness.Additionally, the shortage of production equipment special also limit plant
Composite capsule development at home.Though there being part factory energy large-scale production plant type capsule, mainly it is processed as leading with supplied materials, and
Do not grasp core technology.
For forming the plant polyoses capsule production technology with independent intellectual property right, thoroughly solve the product of traditional gelatine capsule
Quality and safety problem, are upgraded with the replacement realizing capsule formulation.The present invention is using compositions such as Tea Polysaccharides and albumen as plant
Composite capsule exploitation primary raw material, and with content Synergistic, be conducive to lifted capsule quality, realize product functionalization wound
Newly.This is showed no research in existing documents and materials and reports, belongs to first public report.
【Content of the invention】
The purpose of the present invention is exactly to solve the problems of the prior art, proposes a kind of fine based on Folium Camelliae sinensis extract and modified tea
Plant hollow hard capsule and its processing method that dimension, carboxymethyl cellulose, carrageenan, agar etc. are made, this plant hollow hard
Capsule can be used for the fields such as medicine, food and health product.
For achieving the above object, the present invention proposes a kind of tea plant empty hard capsule, by the Folium Camelliae sinensis of 50～70wt%
Lixiviating solution, the modified tea fiber of 15～35wt%, the carboxymethyl cellulose (CMC) of 7.5～12.0wt%, the OK a karaoke club of 0～5wt%
Glue, the agar of 0～8wt%, the plasticizer of 0.3～1.5wt% are prepared from.Aforementioned carrageenan and agar can select in formula
Select and do not put, so also can reach certain effect, if adding the carrageenan of 0.1～more than 5wt% and the fine jade of 0.1～8wt%
If fat, then this programme is better.
Preferably, in described Folium Camelliae sinensis lixiviating solution including but not limited to：2.5～25% tea polyphenols, 4.5～20% egg
White matter, 0.1～5.0% alkaloid, 2.5～20% saccharide, 1～2% theanine, 0.1～0.8% pigment, 0.2～
0.9% vitamin, balance of inorganic matters.
Preferably, described carboxymethyl cellulose is the carboxymethyl cellulose of different viscosities, the carboxylic first of described different viscosities
Base cellulose refers in 25 DEG C of viscositys using Brookfield viscometer surveyed 1wt% high viscosity carboxymethyl cellulose aqueous solution
For 1500～3100mpa.s；The viscosity of 1wt% low viscosity carboxymethyl cellulose aqueous solution is 50～300mpa.s.
Preferably, described plasticizer be glycerol, Sorbitol, PEG400 (PEG-400), propylene glycol, in Mannitol
One or more compounding use.
Preferably, described modification tea fiber refers to the obtained filtering residue after alkalinity extraction of the thick old leaf of Summer-autumn tea through hot blast
Be dried, alkalization, etherification modified, cleaning remove impurity after be prepared from.
Preferably, each component ratio is：The Folium Camelliae sinensis lixiviating solution of 55.1wt%, the modified tea fiber of 25wt%, 10wt%
Carboxymethyl cellulose (CMC), the carrageenan of 3wt%, the agar of 6.5wt%, the plasticizer of 0.4wt%.
For achieving the above object, the invention allows for a kind of preparation method of tea plant empty hard capsule, wrap successively
Include following steps：
A) extract：The thick old leaf of Summer-autumn tea after harvesting is cleaned, dry, pulverize, cross 40 mesh sieves after obtain tealeaf residue, Folium Camelliae sinensis
Slag adds water and is configured to mass concentration (w/v) is 1：40 tealeaf residue solution, that is, every 1 gram of tealeaf residue join 40 milliliters of water, then by tea
Leaf slag solution is mixed with the NaOH of 0.06mol/L；90 DEG C of water-baths extract 40～50min, and every 5min vibrates an extracting solution；Water-bath
Filtered after the completion of extraction, gained filtrate is adjusted to PH=5.0～6.5 with hydrochloric acid (HCl), obtained Summer-autumn tea lixiviating solution；
B) tea fiber is modified：Thick for Summer-autumn tea old leaf is carried out alkalinity extraction, the filtering residue obtaining is cleaned, be dried after, use
75% ethanol, 20% NaOH, alkalize at 30 DEG C of temperature, the rotating speed of 200r/min 90min；Entered with monoxone after alkalization
Row etherification reaction 150min；Afterwards with glacial acetic acid neutralization reaction liquid to PH 7.0～7.5；Decompression sucking filtration, wash to neutral, be dried
Obtain final product modified tea fiber；
C) colloidal sol：After Summer-autumn tea lixiviating solution preheats 5min in 75 DEG C of water-baths, under fast stirring, by solid-to-liquid ratio be 1:15
Carrageenan, solid-to-liquid ratio 1:It is thoroughly mixed in 12 agar addition lixiviating solution；Then by modified tea fiber, different viscosities carboxylic
Methylcellulose presses solid-to-liquid ratio 1 respectively:10 add be sufficiently mixed in 75 DEG C of lixiviating solution stirring 30min form it into uniform and stable
Glue, and be incubated standing 25～40min after adding various adjuvants, then remove solution top layer bubble with scraper plate, that is, formed and dip in
Sol solution；
D) dip in glue base：It is dried by capsule die sufficient lubrication and with hot-air flow first；When dipping in glue, by appropriate gauge
Mould keeps plumbness to be gradually immersed in the glue being cooled to 60 DEG C, after making glue submergence capsule die 5～6s, template is delayed
Delay and lift, leave glue liquid surface, then die flip is allowed to cool for several times, dip in glue speed and be typically advisable with 5～6 times per minute, system
Become capsule base；
E) it is dried：Capsule base is carried out with drying and processing, the temperature of drying is 50～60 DEG C, duration 2～2.5h, softgel shell are dried
Final water content is 6～8wt%；Through pulling out shell, cutting, fastening after, obtain Folium Camelliae sinensis hard capsule.
Preferably, in described c) colloidal sol step different viscosities carboxymethyl cellulose medium-high viscosity carboxymethyl cellulose with low
The mass ratio of viscosity carboxymethyl cellulose is 0.1～1.
For achieving the above object, the invention allows for a kind of purposes of tea plant empty hard capsule, tea plant is empty
Hard-hearted capsule is used in medicine, food and health product capsule agent.
This plant hollow capsule mainly raw material based on Summer-autumn tea extract, and the carboxymethyl with the use of different viscosities
Cellulose, carrageenan, agar etc..The capsule finished product water content prepared is low, good stability, indeformable during storage, not embrittlement,
Drug compatibility is high, and the items physical and chemical index such as elasticity, friability, disintegration and content of beary metal all can meet《Middle traditional Chinese medicines
Allusion quotation》With country, industry standard.The tea plant capsule shaping effect that the present invention provides is good, any surface finish is in pitchy and contains
Many Folium Camelliae sinensis flooding extract active component, have certain pharmacologically active and health care.Generally adopt for existing plant capsule
With more multi-component problem, the present invention from Summer-autumn tea extract and suitable adjuvant collocation, with less component preparation
Go out to meet the tea plant empty hard capsule of all standard, solve defect of the prior art.
Compared with prior art, the invention has the advantages that and beneficial effect：
1. the tea plant empty hard capsule of the present invention, water content is low, be suitable for hygroscopicity by force and to moisture-sensitive medicine
Filling, appearance improves the photophobism of implant in sepia, and has that the suitability is wide, no cross-linking reaction risk and stability is high
Advantage, related physical and chemical index include but is not limited to elasticity, friability, disintegration and content of beary metal etc. meet pharmacopeia and
Concerned countries standard.
2. the plant capsule of the present invention contains multiple Folium Camelliae sinensis flooding extract compositions, has certain pharmacologically active and health care work(
Can, and further increase the biological effect of content medicine.
3. this Novel capsule can be processed with existing gelatine capsule equipment, need not significantly alter original course of processing
And technological parameter, improve utilization rate of equipment and installations, significantly reduce production cost.
4. the present invention is obtained with Summer-autumn tea flooding extract and modified tea fiber for base stock, and raw material is easy to get and low cost
Honest and clean, the basic non-pollutant discharge of production process, it is easy to accomplish industrialized production.
The feature of the present invention and advantage will combine accompanying drawing by embodiment and be described in detail.
【Brief description】
Fig. 1 is the schematic flow sheet of the preparation method of tea plant empty hard capsule in the present invention.
【Specific embodiment】
With reference to being embodied as example, the present invention is described in further detail.It should be understood that example below is only used for
The bright present invention rather than the restriction scope of the invention.
Embodiment 1：
Refering to Fig. 1, the preparation method of tea plant empty hard capsule, comprise the following steps：
(1) sieve and extract：The thick old leaf of Summer-autumn tea after harvesting, after remove impurity cleaning, drying, pulverizing, 40 mesh sieves excessively, is pressed
1:40 (w/v) are mixed with the NaOH of 0.06mol/L.Extract 40min under 90 DEG C of water-baths, every 5min vibration mixed once is extracted
Liquid.Filtration under diminished pressure after the completion of extraction, gained extracting solution is adjusted to PH=5.0-6.5 with dilute HCl.
(2) etherification modified：5g is taken to wash to the neutral and tea grounds after hot air drying in three mouthfuls of burnings with agitating device
In bottle, add 75% ethanol 50ml, 20%NaOH 50ml, 30 DEG C of alkalization temperature, under 200r/min, carry out quaternization 90min.
After alkalization terminates, add 75% ethanol and monoxone, be gradually heating to 70 DEG C of reaction 30min.Add 1.5g NaOH in reaction
In system, 70 DEG C of constant temperature, stirring reaction 150min.Finally use glacial acetic acid (or aqueous hydrochloric acid solution of 0.1mol/L) neutralization reaction liquid
To PH 7.0-7.5.Decompression sucking filtration, 3 times of 75% washing with alcohol 3 times, then with 95% washing with alcohol 1 time, 60 DEG C of drying modifications
Tea fiber.
(3) colloidal sol：After Summer-autumn tea lixiviating solution preheats 5min in 75 DEG C of water-baths, under fast stirring, by carrageenan (solid-liquid
Ratio 1:15), agar (solid-to-liquid ratio 1:12) add in lixiviating solution and be thoroughly mixed.Then by modified tea fiber, different viscosities carboxylic
Methylcellulose (high viscosity CMC and low viscosity CMC mass ratio are 0.5-1) presses solid-to-liquid ratio 1 respectively:10 lixiviating solution adding 75 DEG C
In be sufficiently mixed stirring 30min form it into uniform and stable glue, and add various adjuvants after insulation standing 25-40min,
Remove solution top layer bubble with scraper plate again, that is, formed and dip in sol solution.
(4) dip in glue base：It is dried by capsule die sufficient lubrication and with hot-air flow first.When dipping in glue, by appropriate gauge
Mould keep plumbness be gradually immersed in the glue being cooled to 60 DEG C, after making glue submergence capsule die 5-6s, by template
Slowly lift, leave glue liquid surface, then die flip is allowed to cool for several times, dip in glue speed and be typically advisable with 5-6 time per minute.
(5) it is dried：Capsule is dried and adopts baking oven hot air drying, 50-60 DEG C of baking temperature, and duration 2-2.5h, softgel shell are dried
Final water content is 6-8wt%.Through pulling out shell, cutting, fastening after, obtain described Folium Camelliae sinensis hard capsule.
Embodiment 2：
Different to the process of tea grounds after Folium Camelliae sinensis extraction and colloidal sol mode, other preparation technologies with embodiment 1, in place of difference
For：
Tea grounds digests：By 20%NaOH (or 2% dilution heat of sulfuric acid) with wash to the neutral and tea grounds after hot air drying
Through 10:1 mixing, filter after (liquid 10mL solid 1g) micro-boiling 30min in 120 DEG C of water-baths be washed to neutral standby.To 250ml
It is separately added into 2g in conical flask with stopper and washs cellulase to neutral tea grounds fiber and 100U, add 100ml
0.2mol/L, pH value is 4.8 HAc-NaAc buffer, places it in constant temperature oscillator, and setting speed is 150rmp,
24-48h is reacted at 50 DEG C.Enzymolysis completes, and after being filtered to remove tea grounds, tea grounds enzymolysis solution is incorporated in Folium Camelliae sinensis lixiviating solution, carries out next
Step colloidal sol work.
Colloidal sol：After Folium Camelliae sinensis mixing lixiviating solution preheats 5min in 85 DEG C of water-baths, under fast stirring, by carrageenan (solid-liquid
Ratio 1:15), agar (solid-to-liquid ratio 1:12) add in lixiviating solution and be thoroughly mixed.Then by different viscosities carboxymethyl cellulose
(high viscosity CMC and low viscosity CMC mass ratio are 0.1-1) presses solid-to-liquid ratio 1:It is sufficiently mixed stirring in 10 lixiviating solution adding 75 DEG C
30min forms it into uniform and stable glue, and insulation standing 25-40min after adding various adjuvants, then is removed molten with scraper plate
Liquid top layer bubble, that is, form and dip in sol solution.Remaining preparation technology is with embodiment 1.
Embodiment 3：
Prepare hard capsule of the present invention different to Folium Camelliae sinensis mode of action, other preparation technologies are with embodiment 2.The present embodiment
The cellulase of hydrolysis tea grounds is adjusted to polygalacturonase work with cellulase synergistic, other preparation technologies are with real
Apply example 2.
Embodiment 4：
Compared to embodiment 1, the present embodiment is changed to the modification of extraction tea grounds to discard, and by carrageenan, agar, carboxylic
Methylcellulose isocolloid is substituted for one or more of hydroxypropyl methyl cellulose (HPMC), gellan gum, sodium alginate group
Close, other preparation technologies are with embodiment 1.Specifically it is distinguished as：
Colloidal sol：After Summer-autumn tea lixiviating solution preheats 5min in 85 DEG C of water-baths, under fast stirring, by hydroxypropyl methyl fiber
One or more of plain (HPMC), gellan gum, sodium alginate combination is added in 85 DEG C of lixiviating solution by solid-to-liquid ratio 0.1-0.25
It is sufficiently mixed stirring 30min and form it into uniform and stable glue, and insulation standing 25-40min after adding various adjuvants, then
Remove solution top layer bubble with scraper plate, that is, formed and dip in sol solution.Remaining extraction of sieving, dip in the preparation technologies such as glue with embodiment 1.
Embodiment 5：
Compared to embodiment 1, carrageenan, agar, carboxymethyl cellulose isocolloid are substituted for hydroxypropyl first by the present embodiment
One or more of base cellulose (HPMC), gellan gum, sodium alginate combine, and other preparation technologies are with embodiment 1.Specifically
For：
Colloidal sol：After Summer-autumn tea lixiviating solution preheats 5min in 75 DEG C of water-baths, under fast stirring, by hydroxypropyl methyl fiber
One or more of plain (HPMC), gellan gum, sodium alginate combination is added in 75 DEG C of lixiviating solution by solid-to-liquid ratio 0.1-0.25
It is sufficiently mixed stirring 30min and form it into uniform and stable glue, and insulation standing 25-40min after adding various adjuvants, then
Remove solution top layer bubble with scraper plate, that is, formed and dip in sol solution.Remaining extraction of sieving, dip in the preparation technologies such as glue with embodiment 1.
Embodiment 6：
Prepare hard capsule of the present invention it should be strongly noted that OK a karaoke club in embodiment 2 and embodiment 3 collosol craft
Glue, agar, carboxymethyl cellulose (CMC) isocolloid all can be substituted for hydroxypropyl methyl cellulose (HPMC), gellan gum, Sargassum
One or more of sour sodium combines, and other preparation technologies are held essentially constant.
It should be pointed out that the above is only the preferred embodiment of the present invention, under the premise without departing from the principles of the invention,
Scheme after simple transformation of the present invention is belonged to the protection domain of this patent.
Claims (9)
1. a kind of tea plant empty hard capsule it is characterised in that：By the Folium Camelliae sinensis lixiviating solution of 50～70wt%, 15～35wt%
Modified tea fiber, the carboxymethyl cellulose (CMC) of 7.5～12.0wt%, the carrageenan of 0～5wt%, the agar of 0～8wt%,
The plasticizer of 0.3～1.5wt% is prepared from.
2. as claimed in claim 1 a kind of tea plant empty hard capsule it is characterised in that：Comprise in described Folium Camelliae sinensis lixiviating solution
But it is not limited to：2.5～25% tea polyphenols, 4.5～20% protein, 0.1～5.0% alkaloid, 2.5～20% sugar
Class, 1～2% theanine, 0.1～0.8% pigment, 0.2～0.9% vitamin, balance of inorganic matters.
3. as claimed in claim 1 a kind of tea plant empty hard capsule it is characterised in that：Described carboxymethyl cellulose is not
With the carboxymethyl cellulose of viscosity, the carboxymethyl cellulose of described different viscosities refers to utilize Brookfield viscometer at 25 DEG C
The viscosity of surveyed 1wt% high viscosity carboxymethyl cellulose aqueous solution is 1500～3100mpa.s；1wt% low-viscosity carboxymethyl is fine
The viscosity of the plain aqueous solution of dimension is 50～300mpa.s.
4. as claimed in claim 1 a kind of tea plant empty hard capsule it is characterised in that：Described plasticizer is glycerol, mountain
One or more of pears alcohol, PEG400 (PEG-400), propylene glycol, Mannitol compounding use.
5. as claimed in claim 1 a kind of tea plant empty hard capsule it is characterised in that：Described modification tea fiber refers to the summer
The obtained filtering residue after alkalinity extraction of the thick old leaf of autumn tea through hot air drying, alkalization, etherification modified, cleaning remove impurity after preparation and
Become.
6. a kind of tea plant empty hard capsule as any one of claim 1 to 5 it is characterised in that：Each component ratio
Example be：The Folium Camelliae sinensis lixiviating solution of 55.1wt%, the modified tea fiber of 25wt%, the carboxymethyl cellulose (CMC) of 10wt%, 3wt%
Carrageenan, the agar of 6.5wt%, the plasticizer of 0.4wt%.
7. a kind of preparation method of tea plant empty hard capsule it is characterised in that：In turn include the following steps：
A) extract：The thick old leaf of Summer-autumn tea after harvesting is cleaned, dry, pulverize, cross 40 mesh sieves after obtain tealeaf residue, tealeaf residue adds
It is 1 that water is configured to mass concentration (w/v)：40 tealeaf residue solution, that is, every 1 gram of tealeaf residue join 40 milliliters of water, then by tealeaf residue
Solution is mixed with the NaOH of 0.06mol/L；90 DEG C of water-baths extract 40～50min, and every 5min vibrates an extracting solution；Water-bath extracts
After the completion of filtered, gained filtrate is adjusted to PH=5.0～6.5 with hydrochloric acid (HCl), obtains Summer-autumn tea lixiviating solution；
B) tea fiber is modified：Thick for Summer-autumn tea old leaf is carried out alkalinity extraction, the filtering residue obtaining is cleaned, be dried after, with 75%
Ethanol, 20% NaOH, alkalize at 30 DEG C of temperature, the rotating speed of 200r/min 90min；It is etherified with monoxone after alkalization
Reaction 150min；Afterwards with glacial acetic acid neutralization reaction liquid to PH 7.0～7.5；Decompression sucking filtration, wash to neutral, be drying to obtain and change
Property tea fiber；
C) colloidal sol：After Summer-autumn tea lixiviating solution preheats 5min in 75 DEG C of water-baths, under fast stirring, by solid-to-liquid ratio be 1:15 card
Draw glue, solid-to-liquid ratio 1:It is thoroughly mixed in 12 agar addition lixiviating solution；Then by modified tea fiber, different viscosities carboxymethyl
Cellulose presses solid-to-liquid ratio 1 respectively:It is sufficiently mixed stirring 30min in 10 lixiviating solution adding 75 DEG C and form it into uniform and stable glue
Liquid, and it is incubated standing 25～40min after adding various adjuvants, then remove solution top layer bubble with scraper plate, that is, formed and dip in peptization
Liquid；
D) dip in glue base：It is dried by capsule die sufficient lubrication and with hot-air flow first；When dipping in glue, by the mould of appropriate gauge
Keep plumbness to be gradually immersed in the glue being cooled to 60 DEG C, after making glue submergence capsule die 5～6s, template is slowly carried
Rise, leave glue liquid surface, then die flip is allowed to cool for several times, dip in glue speed and be typically advisable with 5～6 times per minute, make glue
Capsule base；
E) it is dried：Capsule base is carried out with drying and processing, the temperature of drying is 50～60 DEG C, duration 2～2.5h is dried, softgel shell is final
Water content is 6～8wt%；Through pulling out shell, cutting, fastening after, obtain Folium Camelliae sinensis hard capsule.
8. as claimed in claim 7 a kind of preparation method of tea plant empty hard capsule it is characterised in that：Described c) colloidal sol
In step, different viscosities carboxymethyl cellulose medium-high viscosity carboxymethyl cellulose and the mass ratio of low viscosity carboxymethyl cellulose are
0.1～1.
9. a kind of purposes of tea plant empty hard capsule it is characterised in that：Tea plant according to claim 1 is hollow
Hard capsule is used in medicine, food and health product capsule agent.
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| CN112641121A (en) * | 2020-10-10 | 2021-04-13 | 广州启键生物科技有限公司 | Preparation method of filling hollow capsules of hydroxypropyl methylcellulose and algal polysaccharide |
| CN114767651A (en) * | 2022-03-07 | 2022-07-22 | 石家庄华加药用胶囊有限公司 | High-toughness hard plant empty capsule and preparation method thereof |
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