CN102343093B - Seaweed polysaccharide medicinal plant film coating and preparation method thereof - Google Patents
Seaweed polysaccharide medicinal plant film coating and preparation method thereof Download PDFInfo
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- CN102343093B CN102343093B CN2010102432656A CN201010243265A CN102343093B CN 102343093 B CN102343093 B CN 102343093B CN 2010102432656 A CN2010102432656 A CN 2010102432656A CN 201010243265 A CN201010243265 A CN 201010243265A CN 102343093 B CN102343093 B CN 102343093B
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- seaweed polysaccharide
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Abstract
The invention relates to a drug tablet core coating technology, and specifically, relates to a seaweed polysaccharide medicinal plant film coating and a preparation method thereof. The seaweed polysaccharide medicinal plant film coating comprises a component A, a component B, and a water solvent, wherein the component A comprises seaweed polysaccharide and/or dietary vegetable fibers and the component B comprises one or more of modified starch, guar gum, edible pigment and brown seaweed polysaccharide. Specifically, the seaweed polysaccharide medicinal plant film coating comprises 5 to 15 wt% of the seaweed polysaccharide, 9 to 16 wt% of the dietary vegetable fibers, 1 to 3 wt% of the modified starch, 0.5 to 0.1 wt% of the guar gum, 0.1 to 1 wt% of the brown seaweed polysaccharide, based on the total weight of the seaweed polysaccharide medicinal plant film coating, 0.1 to 0.5ppm of the edible pigment, and the balance the water solvent. A film forming agent and the most of auxiliary additives adopted by the preparation method of the seaweed polysaccharide medicinal plant film coating are all high-molecular materials with excellent physiochemical performances. Therefore, after coating, the seaweed polysaccharide medicinal plant film coating has the effects of proofing moisture, avoiding light, covering peculiar smell and resisting wear, is difficult to mildew, is easy for disintegration, and improves greatly a drug dissolution rate, bioavailability and a period of drug validity.
Description
Technical field
The present invention relates to Sargassum polysaccharides medicine label packaging technique, specifically a kind of seaweed polysaccharide medicinal plant film coating and preparation method thereof.
Background technology
Medical coating be spray thin layer on the tablet embryo that raw material is pressed into the good film of stability with the taste of covering medicinal tablet itself and the stability that increases tablet, avoid the active medicine of chemical property and other material generation chemical reactions and go bad etc.Coating material is also a kind of pharmaceutic adjuvant that national SFDA controls and supervises.
Traditional packaging technique is sweet tablet, and its major auxiliary burden composition is Pulvis Talci, uses talcous coated tablet can make the weight of medicine label increase 50%-100%, causes the patient to take a large amount of and the incoherent adjuvant of pharmaceutical compositions.
The 1950's, at first the U.S. developed first thin membrane coated tablet, after this abroad begin one's study and popular film-coated technique, over nearly 10 years in the world the medicinal tablet of 70%-90% all used film coating.
China's film-coated technique is started late, and various thin film coating materials and the film coating procedure of minority medical research unit and pharmaceutical factory development just appear in late 1970s successively, and progressively promote the use of.Until the mid-90 in 20th century China occurred that just the thin packaging technique of thin film develops the stage rapidly.But many pharmacy corporations, due to the raw-material complicated technical reason with preparing of medicated bag clothing, therefore still exist many problems in application.
The main thin film coating material of China is film-coated technique--the Opadry (Opadry) that Shanghai Colorcon Coating Technology Co., Ltd is mainly introduced by Britain at present, be to belong to the film coating that contains hypromellose (HPMC), obtained the approval of Chinese Pharmacopoeia committee and U.S. FDA.Domestic other famous film coating products have the medical coating thin film premixing auxiliary material that the little human relations coating material of Slus film coating agent and Wenzhou City company that Tianjin Si Lusen medical material Science and Technology Ltd. produces produces etc.The material with good medicinal plants film coating effect of China's independent development is high value added product and the technology that current China pharmaceutic adjuvant-medical coating industry needs in a hurry.This technology has actual effectively popularizing action to promoting China's pharmaceutic adjuvant-plant coating industry.
Summary of the invention
The object of the invention is to provide a kind of seaweed polysaccharide medicinal plant film coating and preparation method thereof.
For achieving the above object, the technical solution used in the present invention is:
A kind of seaweed polysaccharide medicinal plant film coating: the plant film coating is for to be comprised of A component, B component and aqueous solvent; Edible glue, aqueous solvent, wherein the A component is fucoidin and/or meals Plant fiber; The B component is one or more in modified starch, guar gum, food coloring, fucoidin; By the fucoidin of coating total weight percent 5-15%, the meals Plant fiber of 9-16%, the modified starch of 1-3%, the guar gum of 0.5-0.1%, the fucoidin of 0.1-1%, and the food coloring of coating gross mass meter 0.1-0.5ppm, surplus is aqueous solvent.Described modified starch is the pharmaceutical grade modified starch.
The preparation method of seaweed polysaccharide medicinal plant film coating: from 80 ℃ of gradient dissolution mechanisms that drop to 50-55 ℃, fully be dissolved in aqueous solvent the fucoidin of aforementioned proportion and/or meals Plant fiber dry powder rear in 50 ℃ of insulations, stand-by; Again that the modified starch of aforementioned proportion, guar gum, food coloring and/or fucoidin stirring and dissolving is even, the quiet 2-4 hour of putting of insulation under room temperature, then with fucoidin and meals Plant fiber's solute, mix homogeneously, and can carry out spray coating after static balance under room temperature, obtain seaweed polysaccharide medicinal plant film coating.
When described gradient is dissolved, fucoidin and meals Plant fiber dry powder join in 80 ℃ of aqueous solvent while stirring in 2-5min.
The present invention compared with prior art has advantages of:
1. quality is good.Because film former of the present invention and most auxiliary additive are all the macromolecular materials of physicochemical property excellence, make the Film coated tablets that is bundled into not only can protection against the tide, lucifuge, taste masking, wear-resisting, and be difficult for going mouldy, easily disintegrate, greatly improved dissolution, bioavailability and the EDD of medicine, it is because the present invention is used for the thin film coating material of medicine label with Sargassum polysaccharides and meals Plant fiber as coating materials.Be a kind of polysaccharide that extracts from marine algae due to Sargassum polysaccharides, this polysaccharide has good hydrophilic, coagulability, reversibility and dilute aqueous solution and has good viscosity etc.Sargassum polysaccharides is as a kind of polysaccharide of structure uniqueness, also be proved to be have antiviral activity, blood coagulation resisting function, the effect of reduction cholesterol, active anticancer and at aspects such as antiulcer, anticoagulations, have comparatively ideal pharmacologically active.It can be used as food additive in many food as thickening agent, coagulant etc.
Have very large biochemical difference between Sargassum and land plant, topmost difference is that algae is used polysaccharide as supporting material, and land plant is to use cellulose as supporting material.The meals Plant fiber is a kind of cellulosic polymer that extracts from natural plants, has the physicochemical properties such as suitable water solublity, hot gelling properties, surface activity, metabolism inertia, antienzyme, pH stability, water-retaining property, thickening property, film property and emulsibility.
2. weightening finish is few.Adopt plant film coating of the present invention not need to add any additive, Sargassum polysaccharides has good bleeding and with the medicine label, good cohesive is arranged.Coating of the present invention only makes plate core weight increase by 2%～3%, and sugar coated tablet (wherein the major auxiliary burden composition is the external Pulvis Talci of having eliminated) often can make label weight increase 50%～100%, and the present invention is seriously lower than the requirement of national 3-5%.
3. fast drying.The coating operating time is short, generally only needs 2～3h.The dry time is with also relevant with the physicochemical properties of raw material outside the Pass operative temperature has.
4. the film-coated film former of seaweed polysaccharide plant is natural Sargassum polysaccharides and meals Plant fiber with helping the membrane raw material, with the chemical solvent of the film coating agent of existing import relatively, the solvent of seaweed polysaccharide plant film coating agent is water, as pharmaceutic adjuvant to human body safety; The solvent that is specially thin film coating materials a lot of in prior art needs with an organic solvent, even these solvents are volatile, and do not affect the quality of coating material, but physiological action and inflammability are arranged more, and be difficult for reclaiming, general plant film-coated technique need to add antiseptic and anti-blushing agent simultaneously.
The solvent of plant film coating raw material of the present invention is that aqueous solvent does not exist any problem to the drug effect of medicine label itself and the recovery of solvent, and water is that a kind of good, healthy atent solvent is compared with organic solvent and had good advantage.
5. applied range, the seaweed polysaccharide plant film coating can be used for the coating of Chinese medicine label and Western medicine label, also can be used for the coating of pill and hard-shell capsule agent.
6. good stability.Not dry and cracked, do not melt.
7. production technology is simple.The film-coated preparation technology of plant does not simply need to increase any other equipment and preparation condition, the existing equipment process conditions can meet the film-coated requirement of plant, making the medicine label carry out the film-coated technology of seaweed polysaccharide plant can standardization, to entering international market, has considerable advantage.
8. cost is low.Sargassum polysaccharides thin film coating material price is low than the cost of import coating materials and sweet tablet.
The specific embodiment
Embodiment 1
The preparation of seaweed polysaccharide medicinal plant film coating:
Pharmaceutical grade Sargassum polysaccharides 21kg, pharmaceutical grade meals Plant fiber (available from Shandong) 30kg inserts 250-300kg with in heat-insulation layer and agitator and the rustless steel agitated kettle with outlet, at least slowly added while stirring 200kg within 3 minutes, 80 ℃ of hot water, fully stir 2-4 hour,, until temperature drops to 50 ℃, when solution is transparence, starts lagging facility and maintain the temperature at 50 ℃.
Add the 0.5kg fucoidin in the agitated kettle that the 200kg capacity is identical with above-mentioned condition in addition, and add 100kg, 25 ℃ of warm water, fully stir 2-4 hour to solution be transparence, add 100-200mg food coloring at the needs according to plant film coating gross mass, continue to stir 1 hour, guarantee the molecular balance of glue and eliminate and stir a large amount of bubbles that produce.
Above-mentioned two pots of materials are put into the rustless steel preserving jar continuation stirring that with lagging facility, also can be connected with high-efficiency coating machine from outlet also to be made between material and reaches balance in 30 minutes in static 1 hour, guarantee all even light of post-injection to medicine label coating material, can be used for the coating of Chinese medicine label and Western medicine label while carrying out spray coating, also can be used for the coating of pill and hard-shell capsule agent.Adopt the coating of the present invention's preparation to spray on above-mentioned label, only make plate core weight increase by 2%～3%, it weighs less than the requirement of national 3-5%.
Embodiment 2
Capacity 250kg-300kg with heat-insulation layer and agitator and the rustless steel agitated kettle with outlet in, add 200kg, 80 ℃ of hot water, stir on limit, and limit adds pharmaceutical grade Sargassum polysaccharides 15kg, meals Plant fiber 42kg, fully stir 3-5 hour,, until temperature drops to 55 ℃, when solution is transparence, starts lagging facility and maintain the temperature at 55 ℃.
At first add 50kg cold water in the agitated kettle that the 100kg capacity is identical with above-mentioned condition in addition, add again 3kg pharmaceutical grade modified starch (available from Jiangsu), fully stir 2-4 hour, add again 50kg, 90 ℃ of hot water also transfer to 60 ℃ with temperature, continue to be incubated and to stir 1 hour, static insulation is standby after 20 minutes.
Above-mentioned two pots of materials are put into the rustless steel preserving jar continuation stirring that with lagging facility, also can be connected with high-efficiency coating machine from outlet also to be made between material and reaches balance, the standby spray coating that carries out in 30 minutes in static 1 hour.
Embodiment 3
Pharmaceutical grade Sargassum polysaccharides 33kg, add 90 ℃ of hot water of 200kg, and in the rustless steel agitated kettle with heat-insulation layer and agitator and material outlet, insulated and stirred 1 hour to solution is transparence.Disconnect naturally static 2 hours of heat-preserving equipment, keep the temperature of solution at 60-70 ℃.
Guar gum 0.2kg, add the warm water of 100kg20-25 ℃, stirs, after static 30 minutes, continue to stir after 10 minutes, mix and continue stirring with above-mentioned Sargassum polysaccharides solution, keep mixing temperature 48-50 ℃, as coating spraying standby material, carried out spray coating in 1-2 hour.
Above-described embodiment is the better embodiment of the present invention; but embodiments of the present invention are not restricted to the described embodiments; other any do not deviate from change, the modification done under spirit of the present invention and principle, substitutes, combination, simplify; all should be the substitute mode of equivalence, within being included in protection scope of the present invention.
Claims (4)
1. seaweed polysaccharide medicinal plant film coating, it is characterized in that: the plant film coating is for to be comprised of A component, B component and aqueous solvent; Wherein the A component is the meals Plant fiber of Sargassum polysaccharides and/or the coating gross weight 9-16% of coating gross weight 5-15%; The B component is one or more in the fucoidin of food coloring, coating gross weight 0.1-1% of guar gum, the coating gross mass meter 0.1-0.5ppm of modified starch, the coating gross weight 0.1-0.5% of coating gross weight 1-3%.
2. by seaweed polysaccharide medicinal plant film coating claimed in claim 1, it is characterized in that: described modified starch is the pharmaceutical grade modified starch.
3. preparation method by seaweed polysaccharide medicinal plant film coating claimed in claim 1, it is characterized in that: from 80 ℃ of gradient dissolution mechanisms that drop to 50-55 ℃, fully be dissolved in aqueous solvent the Sargassum polysaccharides of aforementioned proportion and/or meals Plant fiber dry powder rear in 50 ℃ of insulations, stand-by; Again that the modified starch of aforementioned proportion, guar gum, food coloring and/or fucoidin stirring and dissolving is even, the quiet 2-4 hour of putting of insulation under room temperature, then with Sargassum polysaccharides and meals Plant fiber's solute, mix homogeneously, and can carry out spray coating after static balance under room temperature, obtain seaweed polysaccharide medicinal plant film coating.
4., by the preparation method of seaweed polysaccharide medicinal plant film coating claimed in claim 3, it is characterized in that: when described gradient is dissolved, Sargassum polysaccharides and meals Plant fiber dry powder join in 80 ℃ of aqueous solvent while stirring in 2-5min.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN2010102432656A CN102343093B (en) | 2010-07-30 | 2010-07-30 | Seaweed polysaccharide medicinal plant film coating and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN2010102432656A CN102343093B (en) | 2010-07-30 | 2010-07-30 | Seaweed polysaccharide medicinal plant film coating and preparation method thereof |
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| CN102343093A CN102343093A (en) | 2012-02-08 |
| CN102343093B true CN102343093B (en) | 2013-11-20 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102579391A (en) * | 2012-03-05 | 2012-07-18 | 北京皇岛海洋生物科技有限公司 | Gastric soluble compound seaweed polysaccharide film coating premix and liquid preparation method adopting same |
| CN104857520B (en) * | 2015-04-29 | 2017-12-29 | 南京圣诺生物科技实业有限公司 | A kind of sodium alginate coating solution composition and coating method |
| CN107189772A (en) * | 2017-05-02 | 2017-09-22 | 中国地质大学（武汉） | One kind can water swelling sealing agent |
| CN107151552A (en) * | 2017-05-04 | 2017-09-12 | 中国地质大学（武汉） | One kind can water swelling sealing agent |
| CN107349428A (en) * | 2017-06-07 | 2017-11-17 | 常州道博化工有限公司 | A kind of preparation method of moistureproof stable type film coating pre-mix dose |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1452916A (en) * | 2003-05-13 | 2003-11-05 | 黄海滨 | Edible film containing natural plant extractive and its production process |
| CN101316865A (en) * | 2004-12-03 | 2008-12-03 | 科学与工业研究委员会 | Method for preparing biological degradable membrane from semi-refined kappa carrageen glycan |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1452916A (en) * | 2003-05-13 | 2003-11-05 | 黄海滨 | Edible film containing natural plant extractive and its production process |
| CN101316865A (en) * | 2004-12-03 | 2008-12-03 | 科学与工业研究委员会 | Method for preparing biological degradable membrane from semi-refined kappa carrageen glycan |
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Granted publication date: 20131120 Termination date: 20190730 |