CN101297972A - Special glue for producing algal polysaccharides plant capsules - Google Patents
Special glue for producing algal polysaccharides plant capsules Download PDFInfo
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- CN101297972A CN101297972A CNA200810016403XA CN200810016403A CN101297972A CN 101297972 A CN101297972 A CN 101297972A CN A200810016403X A CNA200810016403X A CN A200810016403XA CN 200810016403 A CN200810016403 A CN 200810016403A CN 101297972 A CN101297972 A CN 101297972A
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Abstract
The invention relates to seaweed chemistry and empty capsules, in particular to a special gum used for producing seaweed polysaccharide plant capsules, comprising a film-forming agent, a filming aid, water, a colloid with thermal reversibility and a coagulant aid. The proportions of the components are calculated by weight: when the water is 100 portions, cellulose hydroxy propyl methyl ether, locust bean gum or acacia is selected as the film-forming agent which is 7 to 15 portions; algal polysaccharides is selected as the filming aid which is 1 to 5 portions; hydrolyzed starch or maltodextrin is selected as the colloid with thermal reversibility which is 1 to 10 portions; dissoluble sylivine or calcium salt is selected as the coagulant aid and when 7kg to 15kg film-forming agent is selected, the dosage is 2ml to 10ml and the weight concentration ranges from 0.5 percent to 1.2 percent. The gum of the invention has reasonable mixture ratio of raw materials and obtained products can meet the product quality required by National Formulary.
Description
Technical field
The present invention relates to Sargassum chemistry and Capsules, specifically a kind of special glue for producing algal polysaccharides plant capsules.
Background technology
Capsules is divided into gastric solubleness Capsules, enteric hollow capsule, soft capsule and hard-shell capsule.Medicinal hollow capsule is a kind of special pharmaceutic adjuvant, and it is along with pharmaceutical preparation enters the digestive system of human body together, by human body is absorbed, so the quality of medicinal hollow capsule is directly connected to the quality and the safety of medicine finished product.
The skin that at present domestic and international duricrust Capsules (common name animal capsule) the employed raw material overwhelming majority of preparation is pig or cattle, the animal proteinum colloid gelatin that bone is made.This zoogenous duricrust Capsules have in use that water content is too high, cholesterol levels is too high and have cause the animal sources infectious disease may wait defective.
The frequent appearance of cattle disease and foot and mouth disease more impels people to put forth effort to discover the new used raw material of duricrust Capsules.
Use the material of vegetative fiber, the variety of issue that can avoid traditional animal sources hard-shell capsule to exist fully as hard-shell capsule.At first its water content can reduce and be unlikely to crisp broken, is fit to filling hygroscopicity medicine.Simultaneously,, can not react, can prolong effective storage life of product greatly with the composition that contains aldehyde radical because its stability better.
Now, there has been sophisticated vegetalitas capsule product-feed listing in countries such as Japan, the U.S., France, though price is high more a lot of than conventional capsule, but still are subjected to very much the welcome of consumer.
The invention motivation and theoretical foundation thereof:
Show according to novelty assessment report: it all is animal capsule manufacture line that China produces these Capsuleses, does not almost have the plant capsule production line, and the plant capsule product is in space state substantially.Though it is plant capsule that the product of indivedual factories statement oneself is arranged, detects these products of discovery through the applicant and can not satisfy the standard-required of country duricrust Capsules product.
There is one of basic reason of above-mentioned these problems, be exactly that the physicochemical properties of producing the plant capsule products material are not had not on top of, can not well select to use the raw material of producing plant capsule, just China does not have the rational formula of sophisticated plant capsule special glue.
Is prerequisite by us to the understanding of these raw material chemical physical properties and practice production that we have had and qualified product index in order to solve this critical technical problems, has proposed the production compatibility of plant capsule special glue.Supply to wish to carry out technological innovation and technological transformation both at home and abroad and wish that enterprise's production plant capsule of lifting capsule technique level carries out reference.
Summary of the invention
Of the present inventionly be to provide a kind of special glue for producing algal polysaccharides plant capsules, its reasonable raw material proportioning, the product that obtains can meet the product quality (main indexes that national standard requires is: Capsules thickness is at the 8-12 silk, and the gastric solubleness time is within 10 minutes) that state-promulgated pharmacopoeia requires.
For achieving the above object, the technical solution used in the present invention is:
1. the principle that material of the present invention is selected for use is:
1) Plant fiber's selection need possess following physicochemical properties:
Has good water solublity; Has good hot gelation; Has good metabolism inertia; Has good antienzyme (ability of opposing enzyme activity, product can keep viscosity to stablize); Has good water-retaining property; PH stability; Good thickening property and film property etc.
2) selection of Sargassum polysaccharides need possess following physical property: have good dissolubility; Stronger viscosity (can show viscosity) in very low concentration; Good coagulability and gel strength etc.
According to the present invention of these conditions:
Select cellulose hydroxypropyl methyl ether as film former; Select arabic gum or locust bean gum as film former; Select red seaweed polysaccharide glue to help membrane as gel; Select potassium salt or sodium salt as flocculation aid; Select maltodextrin or hydrolyzed starch as the thermal reversibility colloid.
Be specially: special glue for producing algal polysaccharides plant capsules comprises film former, helps membrane, water, thermal reversibility colloid, flocculation aid;
By weight, when water was 100 parts, film former was selected cellulose hydroxypropyl methyl ether, locust bean gum or arabic gum, and it is 7-15 part; Help membrane to select Sargassum polysaccharides, it is 1-5 part; The thermal reversibility colloid is selected hydrolyzed starch or maltodextrin, and it is 1-10 part;
Flocculation aid is soluble potassium salt or calcium salt, and when selecting the 7-15kg film former for use, their consumptions are 2-10ml, and weight concentration is 0.5-1.2%.
Better formula is:
1) by weight, when water was 100 parts, film former cellulose hydroxypropyl methyl ether was 8-10 part, and helping the membrane Sargassum polysaccharides is 2-4 part, and thermal reversibility colloid hydrolyzed starch is 2-3 part; Flocculation aid is soluble potassium salt or calcium salt, and when selecting the 8-10kg film former for use, its consumption is 2-10ml, and concentration is 0.5-1.0%.
2) by weight, when water was 100 parts, the film former arabic gum was 7-10 part, and helping membrane is Sargassum polysaccharides 2-4 part, and it is 3-5 part that the thermal reversibility colloid is selected maltodextrin; Flocculation aid is soluble potassium salt or calcium salt, and when selecting the 7-10kg film former for use, its consumption is 0.5-1.2% for 2-10ml concentration; Described Sargassum polysaccharides is preferably the manna carbohydrate gum at this.
Described potassium salt can be potassium chloride, potassium phosphate and/or potassium citrate respectively, described calcium salt is a calcium citrate.
Major advantage of the present invention is:
1. announce the plant capsule raw materials for production compatibility technology of restriction China capsule adjuvant industry development first, the selection of plant capsule raw material has science and practicality.
Cellulose hydroxypropyl methyl ether is that a kind of meals Plant fiber compares with animal glue to have and the protein cross reaction be difficult for to take place and do not have problem such as animal sources pollution; Sargassum polysaccharides has numerous functional effects such as antioxidation, raising body immunity.The meals Plant fiber only just can form under the condition of Sargassum polysaccharides and these two kinds of materials existence of flocculation aid has flexible plant capsule.Therefore the selection of plant capsule raw material has science very much, also is one of main factor of restriction China's plant capsule industry development.
2. the product of proportioning raw materials acquisition can meet the product quality (can reach fully) that state-promulgated pharmacopoeia requires under reasonable production technology prerequisite.
The plant capsule that the prescription that provides according to the applicant is produced can meet State Food and Drug Administration to capsular prescription (patent applicant produces the product that meets national standard in enterprise, and Beijing Tongrentang uses).
3. best innovation part is: can change China and only can produce the capsular situation of animal in decades!
The U.S. food drug control FDA of committee has announced that recently the U.S. in 2010 must substitute the animal capsule with plant capsule comprehensively.This patent is announced seaweed polysaccharide plant capsule special glue technology in China first.
1) the present invention develops and discloses the main production raw material of plant capsule and working concentration etc. first;
2 the present invention are fit to national various territorial environment capsule enterprise and produce.
3) production technology of the present invention is simple, and is with low cost, and raw material is easy to get, and raw material control is convenient, uses simple and very high technology content (obtaining by research, test and practice) is arranged.
The specific embodiment
Main meaning of the present invention: the plant capsule special glue succeed in developing the lifting that can quicken China's capsule adjuvant industry technology level, can break external blockade on new techniques and control fully, improve the product quality class of the pharmaceutic adjuvant industry of China implementation of China.
In recent years along with the Institute of Oceanology of the Chinese Academy of Sciences studies to such an extent that deepen continuously to medicinal hollow capsule, a lot of enterprises have recognized plant capsule development and the significance and importance of producing, therefore a lot of enterprises rush forward, and indivedual enterprises have externally avowed the product that has had plant capsule.
But according to our investigation, the inreal critical technical problems of grasping of these enterprises---prescription of plant capsule raw materials for production just, so our so-called plant capsule product of seeing and not in full conformity with the requirement of state-promulgated pharmacopoeia and standard.
Main meaning of the present invention is the proof by the research and the production practices of our specialty, and the seaweed polysaccharide plant capsule special glue of invention is helpful to these enterprises.
Embodiment 1
When the umber of water is 100, the weight proportion of various material demands is: 8 kilograms of viscositys are that 10 centipoises (viscositys in the time of 20 ℃) cellulose hydroxypropyl methyl ether is dissolved in 70 kilogram of 30 degree warm water, after stirring dissolving, the Sargassum polysaccharides that adds 2 kilograms is heated to 70 degree while stirring as flocculating agent, adds the calcium citrate of 2ml 0.5% again as flocculation aid after 2 kinds of materials fully dissolve.3 kilograms of hydrolyzed starches are added 30 kg of water dissolving back to be mixed also water-bath and is warmed to 70 and spends with above-mentioned solution, after keeping making all substances reach molecular balance at least more than 2 hours, under 45 degree temperature conditions, the capsule template is immersed wherein 5 seconds, take out the back and in 35 degree drying alleys, dry, pull out the ball demoulding then.The thickness of the Capsules of the formulation that provides according to this embodiment meets the requirement of standard within the national gastric solubleness 10 minutes about 10.
Embodiment 2
Umber according to water is the weight of 100 o'clock various material demands: get 10 kilograms of viscositys and be and be dissolved in after 10 centipoises (viscositys in the time of 20 ℃) cellulose hydroxypropyl methyl ether, 3 kilograms Sargassum polysaccharides mix in 80 kilogram of 70 degree hot water, after stirring dissolving, the calcium ion that adds 5ml 0.5% is as flocculation aid.2 kilograms of hydrolyzed starches are added 20 kg of water dissolving back to be mixed also water-bath and is warmed to 70 and spends with above-mentioned solution, the balancing response time keeps more than at least 2 hours, under 48 degree temperature conditions, the capsule template is immersed wherein 3-4 second, take out the back and in 35 degree drying alleys, dry, pull out the ball demoulding then.The thickness of the Capsules of the formulation that provides according to this embodiment meets the requirement of standard within the national gastric solubleness 10 minutes about the 9-10 silk.
Embodiment 3
Umber according to water is the weight of 100 o'clock various material demands: get 7 kilograms of arabic gums and 3 kilograms of Sargassum polysaccharides are dissolved in 70 kg of water, be heated to 75 degree, stirred about 1 hour, the potassium citrate solution that adds 10ml 1.0% stirs once more as flocculation aid.After adding 3 kilograms of usefulness 30 kg of water dissolvings of maltodextrin, above-mentioned solution merging is heated to 50 degree.Keep reacting balance time after 2 hours, make temperature remain on 45 and the capsule template is immersed wherein 3-4 second when spending, it is dry in 35 degree bakers to take out the back, pulls out the ball demoulding and gets final product.
The thickness of the Capsules of the formulation that provides according to this embodiment meets the requirement of standard within the national gastric solubleness 10 minutes about the 9-10 silk.
Embodiment 4
Umber according to water is the weight of 100 o'clock various material demands: get 13 kilograms of arabic gums and 5 kilograms of Sargassum polysaccharides are dissolved in 90 kg of water, be heated to 90 degree, stirred about 1 hour, the potassium citrate solution that adds 8ml 1.0% stirs once more as flocculation aid.After adding 5 kilograms of usefulness 10 kg of water dissolvings of maltodextrin, above-mentioned solution merging is heated to 55 degree.Keep reacting balance time after 2 hours, make temperature remain on 50 and the capsule template is immersed wherein 2-3 second when spending, it is dry in 35 degree bakers to take out the back, pulls out the ball demoulding and gets final product.
The thickness of the Capsules of the formulation that provides according to this embodiment meets the requirement of standard within the national gastric solubleness 10 minutes about the 9-10 silk.
Embodiment 5
Umber according to water is the weight of 100 o'clock various material demands: get 15 kilograms of arabic gums and 4 kilograms of Sargassum polysaccharides are dissolved in 65 kg of water, be heated to 90 degree, stirred about 1 hour, the potassium citrate solution that adds 6ml 1.2% stirs once more as flocculation aid.After adding 9 kilograms of usefulness 35 kg of water dissolvings of maltodextrin, above-mentioned solution merging is heated to 55 degree.Keep reacting balance time after 2 hours, make temperature remain on 50 and the capsule template is immersed wherein 2-3 second when spending, it is dry in 35 degree bakers to take out the back, pulls out the ball demoulding and gets final product.
The thickness of the Capsules of the formulation that provides according to this embodiment meets the requirement of standard within the national gastric solubleness 10 minutes about the 9-10 silk.
Claims (5)
1. special glue for producing algal polysaccharides plant capsules is characterized in that: comprise film former, help membrane, water, thermal reversibility colloid, flocculation aid;
By weight, when water was 100 parts, film former was selected cellulose hydroxypropyl methyl ether, locust bean gum or arabic gum, and it is 7-15 part; Help membrane to select Sargassum polysaccharides, it is 1-5 part; The thermal reversibility colloid is selected hydrolyzed starch or maltodextrin, and it is 1-10 part;
Flocculation aid is soluble potassium salt or calcium salt, and when selecting the 7-15kg film former for use, their consumptions are 2-10ml, and weight concentration is 0.5-1.2%.
2. according to the described special glue for producing algal polysaccharides plant capsules of claim 1, it is characterized in that: comprise film former, help membrane, water, thermal reversibility colloid, flocculation aid;
By weight, when water was 100 parts, film former cellulose hydroxypropyl methyl ether was 8-10 part, and helping the membrane Sargassum polysaccharides is 2-4 part, and thermal reversibility colloid hydrolyzed starch is 2-3 part;
Flocculation aid is soluble potassium salt or calcium salt, and when selecting the 8-10kg film former for use, its consumption is 2-10ml, and concentration is 0.5-1.0%.
3. according to the described special glue for producing algal polysaccharides plant capsules of claim 1, it is characterized in that: comprise film former, help membrane, water, thermal reversibility colloid, flocculation aid;
By weight, when water was 100 parts, the film former arabic gum was 7-10 part, and helping membrane is Sargassum polysaccharides 2-4 part, and it is 3-5 part that the thermal reversibility colloid is selected maltodextrin;
Flocculation aid is soluble potassium salt or calcium salt, and when selecting the 7-10kg film former for use, its consumption is 0.5-1.2% for 2-10ml concentration.
4. according to the described special glue for producing algal polysaccharides plant capsules of claim 3, it is characterized in that: described Sargassum polysaccharides is the manna carbohydrate gum.
5. according to claim 1,2 or 3 described special glue for producing algal polysaccharides plant capsules, it is characterized in that: described potassium salt can be potassium chloride, potassium phosphate and/or potassium citrate respectively, described calcium salt is a calcium citrate.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200810016403XA CN101297972B (en) | 2008-05-24 | 2008-05-24 | Special glue for producing algal polysaccharides plant capsules |
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| CN200810016403XA CN101297972B (en) | 2008-05-24 | 2008-05-24 | Special glue for producing algal polysaccharides plant capsules |
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| CN101297972A true CN101297972A (en) | 2008-11-05 |
| CN101297972B CN101297972B (en) | 2010-12-22 |
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| CN200810016403XA Expired - Fee Related CN101297972B (en) | 2008-05-24 | 2008-05-24 | Special glue for producing algal polysaccharides plant capsules |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102696942A (en) * | 2012-05-24 | 2012-10-03 | 海南大学 | Method for preparing nutrient capsules containing marine organism polysaccharide |
| CN102743358A (en) * | 2012-06-19 | 2012-10-24 | 中国科学院烟台海岸带研究所 | Hollow capsule and its preparation method and application |
| CN104127877A (en) * | 2014-07-29 | 2014-11-05 | 浙江益立胶囊有限公司 | Plant hollow capsule |
| CN105267181A (en) * | 2014-06-12 | 2016-01-27 | 成都国弘医药有限公司 | Esomeprazole-magnesium-containing enteric pellet capsule |
| CN106074437A (en) * | 2016-07-13 | 2016-11-09 | 华侨大学 | The seaweed polysaccharide plant empty capsules of a kind of not plasticizer-containing and production method thereof |
| CN106727411A (en) * | 2016-12-14 | 2017-05-31 | 中国科学院海洋研究所 | Algin autonomic soft capsules softgel shell and preparation method |
| CN108014086A (en) * | 2017-12-26 | 2018-05-11 | 中国科学院海洋研究所 | A kind of preparation method of algal polysaccharide sulfate capsule |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102614148B (en) * | 2011-01-31 | 2014-05-28 | 中国科学院海洋研究所 | Vegetable fiber hollow capsule used for medicine and its preparation method |
-
2008
- 2008-05-24 CN CN200810016403XA patent/CN101297972B/en not_active Expired - Fee Related
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102696942A (en) * | 2012-05-24 | 2012-10-03 | 海南大学 | Method for preparing nutrient capsules containing marine organism polysaccharide |
| CN102743358A (en) * | 2012-06-19 | 2012-10-24 | 中国科学院烟台海岸带研究所 | Hollow capsule and its preparation method and application |
| CN105267181A (en) * | 2014-06-12 | 2016-01-27 | 成都国弘医药有限公司 | Esomeprazole-magnesium-containing enteric pellet capsule |
| CN105267181B (en) * | 2014-06-12 | 2019-04-02 | 成都国为生物医药有限公司 | A kind of enteric-coated pellet capsule pharmaceutical composition containing esomeprazole magnesium |
| CN104127877A (en) * | 2014-07-29 | 2014-11-05 | 浙江益立胶囊有限公司 | Plant hollow capsule |
| CN106074437A (en) * | 2016-07-13 | 2016-11-09 | 华侨大学 | The seaweed polysaccharide plant empty capsules of a kind of not plasticizer-containing and production method thereof |
| CN106727411A (en) * | 2016-12-14 | 2017-05-31 | 中国科学院海洋研究所 | Algin autonomic soft capsules softgel shell and preparation method |
| CN106727411B (en) * | 2016-12-14 | 2020-03-10 | 中国科学院海洋研究所 | Seaweed gel plant soft capsule shell and preparation method thereof |
| CN108014086A (en) * | 2017-12-26 | 2018-05-11 | 中国科学院海洋研究所 | A kind of preparation method of algal polysaccharide sulfate capsule |
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| Publication number | Publication date |
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| CN101297972B (en) | 2010-12-22 |
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