CN109908102B - Shell forming composition for preparing plant soft capsules and method for preparing soft capsules - Google Patents
Shell forming composition for preparing plant soft capsules and method for preparing soft capsules Download PDFInfo
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Abstract
The invention belongs to the technical field of medicines, and particularly relates to a composition for preparing a plant soft capsule and application thereof. The composition comprises starch and/or dextrin, artemisia glue, a gelling agent, a plasticizer and the balance of water. According to the invention, the artemisia glue is introduced into the starch and/or cyclodextrin, the gelling agent derived from a small amount of plant glue, the plasticizer and the water to obtain the composition, and the composition can obtain a gel rubber with higher toughness through a sol-gel process under the strong adhesion action of the artemisia glue and starch molecules (and/or dextrin molecules), so that the raw material cost is reduced, the production efficiency and the product quality of the plant soft capsule are ensured, and the plant soft capsule produced by using the composition has economic benefits and popularization values.
Description
Technical Field
The invention belongs to the technical field of medicines, and particularly relates to a composition for preparing a plant soft capsule and application thereof.
Background
The soft capsule belongs to a packaging mode of capsules, is commonly used in medicines or health-care foods, and is a capsule which is prepared by directly encapsulating a certain amount of liquid medicines or dissolving or dispersing solid medicines in a proper excipient to prepare solution, suspension, emulsion or semisolid and sealing the solution, the suspension, the emulsion or the semisolid in a spherical or elliptic soft capsule material. The soft capsule has the advantages that the embedded content is completely isolated from external factors such as air and the like, so that the active ingredients in the content are prevented from being damaged by the external factors; the volatile and oxidizable components can be effectively maintained, the content or the net content of each active component of a single capsule particle can be stably maintained, and the medicinal and health-care values of the contents are ensured; can effectively mask the peculiar smell of partial functional medicines or foods and reduce the sense rejection of consumers. The gelatin skin of the common soft capsule product at present takes gelatin which is derived from animal bones or leather as a main raw material, and the gelatin is an excellent heat reversible gelling agent, has excellent elasticity, toughness and gel-sol transition temperature, and is widely applied to the field of food and medicine. At the end of the last century, the outbreak of mad cow disease eventually dragged the gelatin product into an unprecedented crisis. In addition, gelatin capsules themselves suffer from a number of disadvantages, such as: microorganisms are easy to breed and absorb moisture, the low environmental humidity is poor in flexibility and easy to break, the high environmental humidity is easy to adhere, and therefore medicines which are easy to absorb moisture or sensitive to water cannot be filled; the gelatin molecular chain contains a large number of active groups, and is easy to react with the filled medicine.
The use of plant-based raw materials for the preparation of soft capsules is undoubtedly an effective solution to the above problems. However, the research on the vegetable soft capsule rubber is still relatively little, and although some patents report, the formulation still has the points of continuous improvement and perfection.
US patent 5,342,626 describes the preparation of vegetable soft capsules by rotary moulding, wherein the capsule shell is made of carrageenan, mannan, gellan gum or a mixture of polysaccharides of vegetable origin.
Chinese patent CN 201610677342.6 discloses a composition capable of being made into a capsule wall material of a plant soft capsule, wherein the composition comprises agar, locust bean gum, a plasticizer and an adjuvant.
As is known, the botanical polysaccharide extract is expensive and is not easily affordable to consumers as a capsule material source, and thus, many patents consider introducing cheap starch raw materials and preparing the capsule material of the soft capsule by mixing the botanical polysaccharide and the starch raw materials.
Chinese patent CN 201110271792.2 discloses a konjac polysaccharide composite soft capsule shell, which comprises, by weight, 0.5-8 parts of konjac polysaccharide, 2-10 parts of wheat starch, 3-15 parts of kappa-carrageenan, 0.2-4 parts of xanthan gum, 7-45 parts of swelling agent, 6-30 parts of plasticizer and 0.5-3 parts of other additives.
Chinese patent CN 201410258075.X discloses a plant soft capsule, which is characterized in that the weight ratio of the components is as follows: 100 parts of purified water, 1-30 parts of sesbania gum, 10-60 parts of pregelatinized starch, 0.5-19 parts of a film forming agent, 0.01-1 part of a surfactant, 3-50 parts of a plasticizer and 0-3 parts of a pigment and an opacifier respectively.
Chinese patent CN 201410546365.4 discloses a formula of a non-gelatin soft capsule shell, which comprises modified starch, carrageenan, a plasticizer, water and a thickening agent, wherein the weight percentages of the components are as follows: 25-75% of modified starch; 10-30% of carrageenan; 10-25% of a plasticizer; 40-50% of water; 2-12% of a thickening agent; pigment added according to the required color of the soft capsule.
Chinese patent CN 201480036675.X discloses a shell-forming composition for soft capsules containing a core comprising a phospholipid-containing oil having a phospholipid concentration of 20% by mass or more, said composition comprising: (A) starch and/or dextrin; (B) a gelling agent; (C) glycerin and (D) sorbitol; wherein (C) glycerin: and (D) the mass ratio of the sorbitol is (100:30) - (100: 120). Wherein the gelling agent is one or two or more selected from carrageenan, locust bean gum, natural gellan gum and deacylated gellan gum.
Chinese patent No. cn201480082150.x discloses a method for preparing soft capsules using a composition consisting of modified starch and iota-carrageenan in a weight ratio of the modified starch to the iota-carrageenan of 4.1:1 to 6.5:1 without using a buffer of a chemical metal salt.
Chinese patent CN201580053770.5 discloses a composition of soft capsule coating, which comprises i-carrageenan and waxy corn starch obtained by wet heat treatment in the presence of salt.
However, although the vegetable polysaccharide gelling agent is expensive and is often very suitable as a gelling agent in many food fields, particularly as a thickener, most of them do not have toughness and elasticity of gelatin gel, particularly their gel-sol temperature is often higher than the sol-gel temperature, so that in the production process of preparing soft capsules, the production efficiency is low, the capsule sealing and bonding is not firm, the quality is unstable, and starch derivatives do not have the property of generating reversible gel, and the addition of the starch and starch derivatives to the gelling agent formed by vegetable polysaccharide is often only used as a filler, which cannot increase the mechanical strength of the vegetable polysaccharide gel, but rather often destroys the mechanical strength of the vegetable polysaccharide gel to a certain extent. Therefore, although there are many patents, the shadow of the vegetable soft capsule is rarely seen in the market, and a small amount of products are also prepared from seaweed glue powder which is introduced in the united states or korea and uses carrageenan and the like as main raw materials, which is expensive and has low production efficiency.
Disclosure of Invention
In order to overcome the defects in the prior art, the invention provides a composition for preparing a plant soft capsule, which comprises starch and/or dextrin, artemisia desertorum gum, a gelling agent and a plasticizer.
According to an embodiment of the present invention, the starch may be native starch or modified starch, for example may be one or more of corn starch, potato starch, tapioca starch, wheat starch, oxidized starch, acid-treated starch, hydroxypropyl starch, starch acetate, preferably oxidized corn starch, oxidized tapioca starch, oxidized potato starch, acid-treated starch, hydroxypropyl corn starch, hydroxypropyl tapioca starch.
According to an embodiment of the present invention, the dextrin may be one or more of maltodextrin, yellow dextrin, white dextrin, preferably maltodextrin.
According to an embodiment of the present invention, the gelling agent may be one or more of carrageenan (e.g., kappa-carrageenan, iota-carrageenan, lambda-carrageenan, etc.), pectin, xanthan gum, locust bean gum, gellan gum, agar, sesbania gum, konjac gum, preferably one or more of carrageenan, gellan gum, agar, xanthan gum.
According to an embodiment of the present invention, the plasticizer may be one or more of glycerin, sorbitol, xylitol, mannitol, preferably one or more of glycerin, sorbitol.
According to an embodiment of the present invention, the starch and/or dextrin in the composition may be 20 to 60 parts, for example 30 to 50 parts, and examples thereof may be 40 parts;
the amount of the artemisia glue is not less than 0.02 parts, preferably not less than 0.1 parts, more preferably not less than 0.5 parts, and examples thereof may be 0.1 parts, 0.5 parts, 1 part, 1.5 parts, 2 parts, 3 parts, 4 parts, particularly preferably 0.5 to 3 parts.
The gelling agent may be 0.1 to 20 parts, for example 0.2 to 15 parts, such as 0.5 to 8 parts, and examples thereof may be 2 parts;
the plasticizer may be 5 to 80 parts, for example 10 to 70 parts, such as 12 to 60 parts, and examples thereof may be 16 parts;
according to an embodiment of the invention, the balance of the composition is water.
The water may be 5 to 100 parts, for example 10 to 90 parts, such as 20 to 80 parts, and an example thereof may be 40 parts.
According to an embodiment of the invention, the composition comprises the following components in parts by weight: 40 parts of starch and/or dextrin, 0.5-3 parts of artemisia glue, 0.5-8 parts of a gelling agent, 12-60 parts of a plasticizer and 20-80 parts of water.
According to an embodiment of the present invention, other auxiliary materials may be added to the composition as needed, and the other auxiliary materials may be selected from one or more of a masking agent, a pigment, and a coagulant aid, for example.
According to an embodiment of the present invention, the shielding agent may be one or more of titanium dioxide and calcium carbonate.
According to an embodiment of the present invention, the coagulant aid may be one or more of sodium chloride, potassium carbonate, potassium citrate, potassium acetate, calcium chloride or calcium acetate, preferably one or more of potassium chloride and sodium chloride.
According to an embodiment of the present invention, when one or more of a masking agent, a pigment, a coagulant aid is further included in the composition, the masking agent may be 0.01 to 0.5 parts, such as 0.05 to 0.2 parts, and examples thereof may be 0.1 parts, in parts by weight;
the coagulant aid may be 0.0001 to 0.005 parts, for example, 0.0005 to 0.002 parts, and an example thereof may be 0.001 parts.
The invention also provides application of the composition, which can be used for preparing plant soft capsules.
The invention also provides a method for preparing the plant soft capsule by using the composition, which comprises the following steps: the composition is subjected to high-temperature glue melting and bubble removal, and then the plant soft capsule is produced by conventional equipment.
According to embodiments of the invention, the elevated temperature may be from 70 ℃ to 120 ℃, such as from 80 ℃ to 100 ℃, examples of which may be 85 ℃, 90 ℃, 92 ℃;
the time of the high-temperature glue melting can be 0.5-6 h, such as 0.5-4 h, and an example thereof can be 2 h.
The conventional apparatus may be an apparatus for preparing soft capsules as is conventional in the art, such as a conventional rotary die production apparatus.
The invention also provides an empty capsule or a soft capsule, which is prepared from the composition.
The invention has the beneficial effects that:
according to the invention, the artemisia glue is introduced into the starch and/or cyclodextrin, the gelling agent derived from a small amount of plant glue, the plasticizer and the water to obtain the composition, and the composition can obtain a gel rubber with higher toughness through a sol-gel process under the strong adhesion action of the artemisia glue and starch molecules (and/or dextrin molecules), so that the raw material cost is reduced, the production efficiency and the product quality of the plant soft capsule are ensured, and the plant soft capsule produced by using the composition has economic benefits and popularization values.
Detailed Description
The present invention will be described in further detail with reference to specific examples. It is to be understood that the following examples are only illustrative and explanatory of the present invention and should not be construed as limiting the scope of the present invention. All the technologies realized based on the above-mentioned contents of the present invention are covered in the protection scope of the present invention.
The experimental methods used in the following examples are all conventional methods unless otherwise specified; reagents, materials and the like used in the following examples are commercially available unless otherwise specified.
Example 1
The composition is prepared from the following components in parts by weight: 40 parts of oxidized corn starch, 0.1 part of artemisia glue, 0.5 part of gellan gum, 12 parts of glycerol and 20 parts of water.
Heating the composition for preparing the plant soft capsule in a sol tank to 100 ℃, wherein the heating time is 30 minutes, degassing, and preparing the capsule by adopting conventional soft capsule preparation equipment.
The rubber does not crack in the production process, and the production can be continuously and stably carried out.
Example 2
The composition is prepared from the following components in parts by weight: 40 parts of hydroxypropyl corn starch, 3 parts of artemisia glue, 8 parts of carrageenan, 60 parts of glycerol and 80 parts of water.
The composition for preparing the plant soft capsule is further added with 0.001 part of potassium chloride to be heated to 80 ℃ in a sol-dissolving tank, the heating time is 4 hours, and after degassing, the capsule is prepared by adopting conventional soft capsule preparation equipment.
The rubber does not crack in the production process, and the production can be continuously and stably carried out.
Example 3
The composition is prepared from the following components in parts by weight: 40 parts of acid-treated starch, 1 part of artemisia glue, 2 parts of agar, 60 parts of sorbitol and 40 parts of water.
The composition for preparing the plant soft capsules is further added with 0.1 part of titanium dioxide in a sol tank, heated to 90 ℃ for 2 hours, degassed and prepared into capsules by adopting conventional soft capsule preparation equipment.
The rubber does not crack in the production process, and the production can be continuously and stably carried out.
Example 4
The composition is prepared from the following components in parts by weight: 40 parts of hydroxypropyl cassava starch, 1.5 parts of artemisia glue, 2 parts of carrageenan, 60 parts of mannitol and 40 parts of water.
Heating the composition for preparing the plant soft capsule in a sol tank to 90 ℃ for 2 hours, degassing, and preparing the capsule by adopting conventional soft capsule preparation equipment.
The rubber does not crack in the production process, and the production can be continuously and stably carried out.
Example 5
The composition is prepared from the following components in parts by weight: 40 parts of maltodextrin, 2 parts of artemisia glue, 2 parts of carrageenan, 16 parts of glycerol and 40 parts of water.
Heating the composition for preparing plant soft capsule in a sol-gel tank to 85 deg.C for 2 hr, degassing, and making into capsule by conventional soft capsule preparation equipment.
The rubber does not crack in the production process, and the production can be continuously and stably carried out.
Example 6
Six kinds of artemisia glue with different dosages are respectively weighed, 1 part of kappa-carrageenan, 40 parts of hydroxypropyl corn starch, 42 parts of water and 12 parts of glycerin are added into each amount of artemisia glue to prepare six compositions, after the six compositions are subjected to high-temperature sol at the temperature of 92 ℃ for 2 hours, degassing bubbles are removed, soft capsules are produced by a rotary die soft capsule device, and the tensile strength of a rubber skin is tested, and the results are shown in table 1.
And (3) testing the tensile strength: using an Instron model 1122 test system, the samples to be tested were equilibrated for 5 hours in a constant temperature and humidity cabinet (temperature 23 ℃ C., relative humidity 50%) and tested as specified in GB/T13735-1992.
TABLE 1 tensile Strength testing of compositions formulated with varying amounts of Artemisia glue
| Amount of Artemisia desertorum glue/part | 0 | 0.1 | 0.5 | 1 | 2 | 3 |
| Tensile strength/MPa of rubber | 1.0 | 1.2 | 2.1 | 3.6 | 4.2 | 4.7 |
It can be seen that the tensile strength of the gum skin is increased by adding a small amount of artemisia glue in the system, and the tensile strength of the gum skin is also rapidly increased along with the increase of the dosage of the artemisia glue.
The embodiments of the present invention have been described above. However, the present invention is not limited to the above embodiment. Any modification, equivalent replacement, or improvement made within the spirit and principle of the present invention should be included in the protection scope of the present invention.
Claims (11)
1. A composition for preparing a plant soft capsule, wherein the composition comprises starch and/or dextrin, artemisia glue, a gelling agent and a plasticizer; the starch is selected from natural starch or modified starch; the dextrin is selected from one or more of maltodextrin, yellow dextrin and white dextrin; the gelling agent is one or more selected from carrageenan, pectin, xanthan gum, locust bean gum, gellan gum, agar, sesbania gum and konjac gum; the plasticizer is selected from one or more of glycerol, sorbitol, xylitol and mannitol; the composition comprises the following components in parts by weight: 30-50 parts of starch and/or dextrin; 0.5-3 parts of artemisia glue; the gelling agent can be 0.5-8 parts; and 5-80 parts of a plasticizer.
2. The composition of claim 1, wherein the starch is selected from one or more of corn starch, potato starch, tapioca starch, wheat starch, oxidized starch, acid treated starch, hydroxypropyl starch, starch acetate.
3. The composition of claim 1, wherein the balance of the composition is water, and the water is 5 to 100 parts.
4. The composition according to any one of claims 1 to 3, wherein the following components are included in the composition in parts by weight: 40 parts of starch and/or dextrin, 0.5-3 parts of artemisia glue, 0.5-8 parts of a gelling agent, 12-60 parts of a plasticizer and 20-80 parts of water.
5. The composition according to any one of claims 1 to 3, wherein other excipients selected from one or more of a masking agent, a pigment, and a coagulant aid may be added to the composition.
6. The composition of claim 5, wherein the masking agent is one or more of titanium dioxide and calcium carbonate; the coagulant aid is one or more of sodium chloride, potassium carbonate, potassium citrate, potassium acetate, calcium chloride or calcium acetate.
7. The composition of claim 6, wherein when the composition further comprises one or more of a masking agent, a pigment and a coagulant aid, the masking agent is 0.01-0.5 parts and the coagulant aid is 0.0001-0.005 parts by weight.
8. Use of a composition according to any one of claims 1 to 7, wherein said composition is used for the preparation of plant softgels.
9. Process for the preparation of plant soft capsules according to the composition of any one of claims 1 to 7, characterized in that it comprises the following steps: the composition is subjected to high-temperature glue melting and bubble removal, and then the plant soft capsule is produced by conventional equipment.
10. The method for preparing the plant soft capsules by using the composition as claimed in claim 9, wherein the high temperature is 70-120 ℃, the time for melting the gelatin at the high temperature is 0.5-6 h, and the conventional equipment is equipment for preparing the soft capsules conventionally in the field.
11. A soft capsule prepared from the composition of any one of claims 1 to 7.
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| CN111454490B (en) * | 2020-04-14 | 2021-10-22 | 中国科学院化学研究所 | Composition for preparing edible plant plasma membrane and application thereof |
| CN112294775A (en) * | 2020-12-10 | 2021-02-02 | 浙江艾兰得生物科技有限公司 | Plant-based soft capsule rubber with anti-adhesion function |
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