CN103041397A - Sodium alga acid capsule and production process thereof - Google Patents
Sodium alga acid capsule and production process thereof Download PDFInfo
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- CN103041397A CN103041397A CN2013100194214A CN201310019421A CN103041397A CN 103041397 A CN103041397 A CN 103041397A CN 2013100194214 A CN2013100194214 A CN 2013100194214A CN 201310019421 A CN201310019421 A CN 201310019421A CN 103041397 A CN103041397 A CN 103041397A
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Abstract
The invention belongs to the technical field of research and development of medicines and health food, and relates to a formula of a capsule using sodium alga acid as a raw material and a production method. The production method is characterized by comprising the following steps of: weighing 7.0-11.0 percent by weight of sodium alga acid, 1.0-4.0 percent by weight of locust bean gum, 2.0-5.0 percent by weight of CaCO3, 2.0-5.0 percent by weight of NaHCO3 and 2.0-4.0 percent by weight of plasticizers; filling the components into a mixed solution of 75.0-80.0 percent by weight of distilled water and 2.0-5.0 percent by weight of coconut oil; and carrying out gum dissolution, heat preservation, gum-dipping formation, drying, shell pulling, cutting, settling, packaging and the like to obtain the capsule. The capsule is reasonable in formula, safe to orally take and facilitates absorption of medicaments; and the method is wide in sources of the raw materials, low in cost, simple in production process and suitable for industrial production.
Description
Technical field:
The present invention relates to health food and pharmaceutical capsule, particularly a kind of method of producing medical capsule shells with sodium alginate.
Background technology:
At present, the primary raw material that China produces empty hard capsule is gelatin, and gelatin derives from bone and the skin of animal (pig, cattle), and its main component is protein.
Along with the understanding of people to plant capsule, and the transformation of public's medication theory both at home and abroad, the market demand of plant capsule is increased rapidly.Because plant capsule does not use any gelatin, and numerous Moslems patient can take in relieved powder charge, product can export to vast Islam and kosher area, will earn foreign exchange for country, has improved the economic benefit of enterprise simultaneously.
Sodium alginate is a kind of polysaccharide carbohydrate that extracts from the Thallus Laminariae (Thallus Eckloniae) of Brown algae or Alga Sgrgassi Enerves, by relying on 1 by α-L-mannuronic acid (M unit) and β-D-guluronic acid (G unit), the copolymer that the 4-glycosidic bond connects and is comprised of GM, MM and the GG fragment of different proportion, a kind of in the alginic acid derivant, so sometimes also claim sodium alginate or seaweed gel and alginate jelly.Sodium alginate is with its good biological degradability and biocompatibility, and is widely used in the fields such as chemistry, biology, medicine, food.
Summary of the invention:
The object of the present invention is to provide a kind of with sodium alginate production have that extensibility, tension force are strong, the toughness method of medical capsule shells preferably.
The technical solution adopted for the present invention to solve the technical problems is: the film forming raw material of capsule shells contains major ingredient and multiple auxiliary materials mixture, and major ingredient contains sodium alginate, locust bean gum, and adjuvant contains Oleum Cocois, CaCO
3, NaHCO
3, plasticizer, water, also can additionally increase certain additive according to product needed, such as antiseptic, aromatic and coloring agent etc.
1, the prescription of the present invention's sodium alginate capsule shells following (following all by weight percentage):
Hydrophilic gel: 10.0% sodium alginate, 4.0% locust bean gum,
Flocculation aid: 2.0% CaCO
3, 4.0% NaHCO
3,
Correctives, screening agent: 2.0% Oleum Cocois
Plasticizer: sorbitol or xylitol
Water content 13-15% in the product
2, the production technology of the present invention's sodium alginate capsule shells is carried out in accordance with the following steps:
(1) colloidal sol, insulation:
Pure water and Oleum Cocois are mixed and be heated to 60-80 ℃, under constantly stirring, slowly the pressed powder that weighs up is added until form clear solution, then in the dislocation interlayer steam cooker, at 80 ℃ of heating 20min, make it to dissolve into uniform glue.Use again filter cloth (150 order) filter to enter to dip in the glue pot (use water bath heat preservation), 55 ℃ leave standstill 60-90min after, naturally remove the foam on the liquid level, it is for subsequent use that glue is clarified.
(2) dip in gum forming, drying:
Pour glue into the 30min that circulates in the glue groove, dip in glue when observing the glue surface without bubble.Use capsule die, tringle is immersed dip in glue capsule blank in the glue.The tringle of choosing first suitable specification is fixed on the template, with an amount of lubrication of liquid paraffin.Tringle is steadily held, the upper end is immersed downwards in the glue, treat the about 6-8s of the whole submergence tringles of glue, namely slowly template is mentioned, leave glue liquid surface, template is dug again, upset makes cooling for several times, dips in the speed of glue and generally is advisable with 5-6 plate/min.Utilize the hot and cold air drying that flows, room temperature should keep 45-55 ℃, relative humidity 30-40%, and the flow velocity of hot-air is about 12-15m/s, and general 60min gets final product.
(3) pull out shell, cut:
The softgel shell of oven dry is pulled up to get rough blank with pulling out the glue device, rough blank is sent between cutting, cut into early-products according to the model of capsule.
(4) arrangement, packing:
Substandard products, waste product in the capsule that cutting is lower are chosen and are picked.Capsule two is saved fits up and down, and splendid attire is stored in shady and cool dry place in hermetic container, be finished product after the packing.
Specific embodiments:
The preparation technology of a kind of sodium alginate capsule shells of the present invention comprises following examples, and the following examples can further specify the present invention, but do not limit the present invention in any way.
The formula for a product (consisting of by weight percentage) of embodiment 1, the present invention's sodium alginate capsule: 10.0% sodium alginate, 4.0% locust bean gum, 2.0% CaCO
3, 4.0% NaHCO
3, 3.0% sorbitol, 75.0% distilled water and 2.0% Oleum Cocois; The capsule fabrication processing is: the distilled water with 75.0% mixes with 4.0% Oleum Cocois and is heated to 75 ℃, 10.5% the sodium alginate that slowly will weigh up under constantly stirring, 4.5% locust bean gum, 2.5% sorbitol, 3.0% CaCO
3, 4.0% NaHCO
3Add until the formation clear solution in the rear dislocation interlayer steam cooker, at 80 ℃ of heating 20min, makes it to dissolve into uniform glue.Use again filter cloth (150 order) filter to enter to dip in the glue pot (using water bath heat preservation), 55 ℃ leave standstill 80min after, naturally remove the foam on the liquid level.The glue of resting is poured the 30min that circulates in the glue groove into, automatically dips in glue, drying, pulls out shell, namely gets product of the present invention after the cutting, arrangement, packaging and other steps through the capsule shells mould.
The formula for a product (consisting of by weight percentage) of embodiment 2, the present invention's sodium alginate capsule: 11.0% sodium alginate, 3.0% locust bean gum, 2.0% CaCO
3, 3.5% NaHCO
3, 2.5% xylitol, 75% distilled water and 3% Oleum Cocois; The capsule fabrication processing is: the distilled water with 75% mixes with 3% Oleum Cocois and is heated to 80 ℃, 11.0% the sodium alginate that slowly will weigh up under constantly stirring, 3.0% locust bean gum, 2.5% xylitol, 2.0% CaCO
3, 3.5% NaHCO
3Add until the formation clear solution in the rear dislocation interlayer steam cooker, at 80 ℃ of heating 20min, makes it to dissolve into uniform glue.Use again filter cloth (150 order) filter to enter to dip in the glue pot (using water bath heat preservation), 55 ℃ leave standstill 85min after, naturally remove the foam on the liquid level.The glue of resting is poured the 30min that circulates in the glue groove into, automatically dips in glue, drying, pulls out shell, namely gets product of the present invention after the cutting, arrangement, packaging and other steps through the capsule shells mould.
Claims (6)
1. sodium alginate capsule, it is characterized in that: its composition of raw materials and weight proportion are: sodium alginate accounts for 7.0-11.0%, locust bean gum accounts for 1.0-4.0%, CaCO
3Account for 2.0-5.0%, NaHCO
3Account in 2.0-5.0%, sorbitol and the xylitol one or both and account for 2.0-4.0%, put into the Oleum Cocois mixed solution of distilled water and the 2.0-5.0% of 75.0-80.0%, its processing step is: after feeding intake by above-mentioned prescription and weight proportion, through colloidal sol, be incubated, dip in gum forming, drying, pull out shell, get final product after the cutting, arrangement, packing.
2. according to claims 1 described sodium alginate capsule manufacture method, it is characterized in that: described colloidal sol, incubation step are with pure water and Oleum Cocois mixing and are heated to 60-80 ℃, under constantly stirring, slowly the pressed powder that weighs up is added until form clear solution, then in the dislocation interlayer steam cooker, at 80 ℃ of heating 20min, make it to dissolve into uniform glue, use again filter cloth (150 order) filter to enter to dip in the glue pot (using water bath heat preservation), 55 ℃ leave standstill 60-90min after, naturally remove the foam on the liquid level, make the glue clarification for subsequent use.
3. according to claims 1 or 2 described sodium alginate capsule manufacture methods, it is characterized in that: describedly dip in gum forming, drying steps is: first glue is poured into the 30min that circulates in the glue groove, dip in glue when observing the glue surface without bubble, and blank was positioned in 50 ℃, the baking oven of relative humidity 30-40% oven dry 1 hour.
4. according to claims 3 described sodium alginate capsule manufacture methods, it is characterized in that: describedly pull out shell, cutting step is: the softgel shell of oven dry is pulled up to get rough blank with pulling out the glue device, rough blank is sent between cutting, cut into early-products according to the model of capsule.
5. root is dug claims 4 described sodium alginate capsule manufacture methods, and it is characterized in that: described arrangement, packaging step are: the substandard products in the capsule under will cutting, waste product are chosen and are picked.Capsule two is saved fits up and down, and splendid attire is stored in shady and cool dry place in hermetic container, be finished product after the packing.
6. according to claims 5 described sodium alginate capsule manufacture methods, it is characterized in that: described batching, colloidal sol, be incubated, dip in gum forming, drying, pull out shell, cutting, arrangement, packing should carry out in 300,000 grades of clean rooms.
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| CN2013100194214A CN103041397A (en) | 2013-01-04 | 2013-01-04 | Sodium alga acid capsule and production process thereof |
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|---|---|---|---|
| CN2013100194214A CN103041397A (en) | 2013-01-04 | 2013-01-04 | Sodium alga acid capsule and production process thereof |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103877587A (en) * | 2014-04-11 | 2014-06-25 | 江苏省海洋资源开发研究院(连云港) | Plant polysaccharide medicinal enteric hard-shell capsule and preparation method thereof |
| CN104338143A (en) * | 2013-07-31 | 2015-02-11 | 山东大学（威海） | Dropping pill with sodium alginate and methyl cellulose as capsule wall material, and its production technology |
| CN104338144A (en) * | 2013-07-31 | 2015-02-11 | 山东大学（威海） | Dropping pill with sodium alginate and carrageenan as capsule wall material, and its production technology |
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| CN1985809A (en) * | 2005-12-20 | 2007-06-27 | 黄族和 | Preparing process of botanical hollow enteric hard capsule |
| CN101433526A (en) * | 2007-11-13 | 2009-05-20 | 上海慧源植物胶囊股份有限公司 | Non-gelatine enteric hard capsule shell material and method for producing the same |
| CN102078311A (en) * | 2010-12-21 | 2011-06-01 | 中国海洋大学 | Method for preparing marine plant alginate polysaccharide enteric coated hard capsules |
| CN102133207A (en) * | 2011-03-15 | 2011-07-27 | 温州医学院 | Novel capsule colon-specific drug delivery system (CSDDS) and preparation method thereof |
| CN102657869A (en) * | 2012-05-25 | 2012-09-12 | 无锡福尔顺科技有限公司 | Alginate hard capsule disintegrable at different positions in gastrointestinal tract |
-
2013
- 2013-01-04 CN CN2013100194214A patent/CN103041397A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1985809A (en) * | 2005-12-20 | 2007-06-27 | 黄族和 | Preparing process of botanical hollow enteric hard capsule |
| CN101433526A (en) * | 2007-11-13 | 2009-05-20 | 上海慧源植物胶囊股份有限公司 | Non-gelatine enteric hard capsule shell material and method for producing the same |
| CN102078311A (en) * | 2010-12-21 | 2011-06-01 | 中国海洋大学 | Method for preparing marine plant alginate polysaccharide enteric coated hard capsules |
| CN102133207A (en) * | 2011-03-15 | 2011-07-27 | 温州医学院 | Novel capsule colon-specific drug delivery system (CSDDS) and preparation method thereof |
| CN102657869A (en) * | 2012-05-25 | 2012-09-12 | 无锡福尔顺科技有限公司 | Alginate hard capsule disintegrable at different positions in gastrointestinal tract |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104338143A (en) * | 2013-07-31 | 2015-02-11 | 山东大学（威海） | Dropping pill with sodium alginate and methyl cellulose as capsule wall material, and its production technology |
| CN104338144A (en) * | 2013-07-31 | 2015-02-11 | 山东大学（威海） | Dropping pill with sodium alginate and carrageenan as capsule wall material, and its production technology |
| CN103877587A (en) * | 2014-04-11 | 2014-06-25 | 江苏省海洋资源开发研究院(连云港) | Plant polysaccharide medicinal enteric hard-shell capsule and preparation method thereof |
| CN103877587B (en) * | 2014-04-11 | 2016-01-20 | 江苏省海洋资源开发研究院(连云港) | Medicinal enteric hard-shell capsule of a kind of vegetable polysaccharides and preparation method thereof |
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Application publication date: 20130417 |