CN103961334A - Pulullan hollow hard capsule and preparation method thereof - Google Patents
Pulullan hollow hard capsule and preparation method thereof Download PDFInfo
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- CN103961334A CN103961334A CN201410218196.1A CN201410218196A CN103961334A CN 103961334 A CN103961334 A CN 103961334A CN 201410218196 A CN201410218196 A CN 201410218196A CN 103961334 A CN103961334 A CN 103961334A
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- glue
- hollow hard
- pulullan
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- capasule
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Abstract
The invention discloses a Pulullan hollow hard capsule and a preparation method thereof. The Pulullan hollow hard capsule comprises the following components in percentage by weight: 70-96% of Pulullan, 0.2-8% of gelatinizer, 0.01-2% of coagulant aid, 0-2% of surfactant, 0.2-5% of humectant, 0-3% of opacifier and the balance of water. The Pulullan hollow hard capsule has the advantages of higher oxygen barrier property, higher shock strength, stable quality, low tendency to crushing, stable disintegration index and low tendency to hydrolysis, and can not easily produce fog or become yellow on the surface after long-time placement. The raw materials are from pure plants, thereby completely avoiding pollutions which can be caused by animal proteins. The capsule has lower water content than the gelatine capsule, is more suitable for filling hydroscopic drugs and aldehyde-containing drugs, and has wide market prospects and practical value.
Description
Technical field
The present invention relates to a kind of capsule technique field, relate in particular to a kind of pullulan polysaccharide hollow hard capasule taking pulullan polysaccharide as primary raw material and the preparation method of this empty hard capsule.
Background technology
Empty hard capsule is a kind of novel form capsule growing up in fields such as medicine, food, health product, cosmetics in recent years, it is by quantitative packed article pressure injection and is encapsulated in rubber, form seal capsule, there is the advantages such as content is accurate, good uniformity, good looking appearance.
But as the rubber of empty hard capsule, be to be all used as major ingredient gel with gelatin at present substantially.The hard capsule water content of preparing with gelatin has certain limit (12. 5%～17.5%), as lower than this scope, the friability of capsule increases, be unfavorable for the filling of medicine, for easy hygroscopicity medicine (some Chinese herbal medicine), the moisture of capsule is easily filled with thing and draws, and the medicine that filling is good easily splits at storage life capsule; In addition, for unsettled medicine after moisture absorption, also affect expiration date of drug, gelatin can with Cucumber generation crosslinked action, as aldehyde, polyphenol, reducing sugar, multi-charge cation, electrolyte, cation or anionic polymer etc., thereby capsule mechanical performance or biological function are changed; Gelatin not only can be hydrolyzed by protease cracking and strong acid, also can cause degeneration because of highly basic.Therefore,, when filling liquid medicine, pH should be controlled at 4.5～7.5.
The empty hard capsule of preparing with gelatin and the medicine of capsule will have certain constant-temperature constant-humidity environment to store, because of excess Temperature, and the easy softening transform of capsule, temperature is too low, the easy embrittlement of capsule.Gelatin is animal proteinum colloid, and contains certain Animal fat, and in general gelatin, Animal fat content is approximately 2. 2%, easily causes pollution (foot and mouth disease, bovine spongiform encephalopathy etc.), and these shortcomings have restricted applying of empty hard capsule goods.Gelatin materials has also been subject to Moslem/kosher, vegetarian diet personage's resistance.The reason that causes the above-mentioned deficiency of gelatin is mainly because it derives from animal, and therefore, the plant source hard-shell capsule of exploitation natural origin is trend of the times.
Summary of the invention
Technical problem to be solved by this invention is to provide that a kind of disintegration rate is fast, friability is better, appearance is glittering and translucent, oxygen permeability is low, storage time is long, and all raw materials are the pullulan polysaccharide hollow hard capasule of biological preparation without any artificial synthetic ingredient, also provide the preparation method of this pullulan polysaccharide hollow hard capasule simultaneously.
For solving the problems of the technologies described above, technical scheme of the present invention is:
Pullulan polysaccharide hollow hard capasule, comprises following percentage by weight component: pulullan polysaccharide 70～96%, and gel 0.2～8%, flocculation aid 0.01～2%, surfactant 0～2%, wetting agent 0.2～5%, opacifier 0～3%, surplus is moisture;
Wherein:
Described gel is one or more in carrageenan, Wei Lan glue or sodium alginate;
Described flocculation aid is one or more in potassium chloride, calcium chloride, calcium propionate or potassium citrate;
Described surperficial voltinism agent is one or more in dodecyl sodium sulfate, Tween 80, sophorolipid;
Described wetting agent is one or more in glycerol, ethylene glycol, sorbitol;
Described opacifier is titanium dioxide.
As preferred technical scheme, comprise following percentage by weight component: pulullan polysaccharide 80～90%, gel 3～6%, flocculation aid 0.5～2%, surfactant 0.5～1%, wetting agent 2～3%, opacifier 0.5～2%, surplus is moisture.
As the improvement to technique scheme, described pullulan polysaccharide hollow hard capasule, also contains the food coloring of dyeing amount, and the consumption of food coloring can suitably be adjusted with food colour.
The present invention also provides the preparation method of above-mentioned pullulan polysaccharide hollow hard capasule, comprises the following steps:
(1) by said components and percentage by weight, with with the deionized water of 2～5 times of described component gross weights, together join can the heating and stirring tank of evacuation in, control 30～50 revs/min of speeds of agitator, 65～98 DEG C of temperature, each component is stirred to mix homogeneously and completely dissolves and form glue, be incubated 0.5～3 hour;
(2) continue to stir with the speed of 30～50 revs/min, evacuation is eliminated bubble simultaneously;
(3) discharge glue, and use 100～300 object filter bags to filter;
(4) glue of filtration is contained in cool-bag, controls 40～88 DEG C of temperature, leave standstill 0.5～3 hour;
(5), on capsule manufacture equipment, glue, through dipping in glue, dry, the demoulding, trimming, fit, inspection, makes finished product.
Wherein, baking temperature is controlled at 20～75 DEG C, preferably 50～75 DEG C.
Owing to having adopted technique scheme, pullulan polysaccharide hollow hard capasule, comprises following percentage by weight component: pulullan polysaccharide 70～96%, gel 0.2～8%, flocculation aid 0.01～2%, surfactant 0～2%, wetting agent 0.2～5%, opacifier 0～3%, surplus is moisture; The present invention adopts pulullan polysaccharide as material of main part, because pulullan polysaccharide molecule is regular, the change of molecular weight scope is little, product quality is easily controlled, and has higher oxygen barrier and impact strength, and quality stability is good, be difficult for friability, slaking index is stable, not facile hydrolysis, and long-time placement surface is not sent out mist jaundice; Raw material used is pure plant origin, can avoid the pollution (foot and mouth disease, bovine spongiform encephalopathy etc.) because animal proteinum may cause completely.This capsule can be filled lipophile liquid, semisolid and plaster material, and especially all the components of this capsule is all that biological fermentation process is produced, and meets the medicine requirement of Arab countries.This capsule water content, lower than gelatine capsule, is more easily applicable to filling hygroscopicity medicine and aldehyde-containing type medicine, has market prospect and practical value widely.
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention is described further:
embodiment 1:
First, prepare following raw material: pulullan polysaccharide 7000g, carrageenan 800g, glycerol 460g, sorbitol 40g, Tween 80 200g, potassium chloride 200g, titanium dioxide 200g, water 44kg.
Then, prepare according to the following steps capsule: (1) water and all the other raw materials together put into can the heating and stirring tank of evacuation in, after feeding intake, temperature is adjusted to 65 DEG C, mixing speed is adjusted to 30 turn/min, each component is stirred to mix homogeneously and completely dissolves and form glue, be incubated 3 hours; (2) stir with the speed of 30 turn/min, evacuation is eliminated bubble simultaneously; (3) discharge glue, and use 300 object filter bags to filter; (4) glue is rested in the cool-bag of 75 DEG C, leave standstill 3 hours; (5) by the glue making on capsule manufacture equipment through dipping in glue, 20 DEG C are dry, the demoulding, trimming, fit, inspection, makes pullulan polysaccharide hollow hard capasule.
embodiment 2:
First, prepare following raw material: pulullan polysaccharide 9600g, Wei Lan glue 20g, ethylene glycol 20g, sophorolipid 45g, calcium propionate 1g, water 20kg.
Then, prepare according to the following steps capsule: (1) 20kg water join can the heating and stirring tank of evacuation in, allow the speed running of blender with 50 turn/min; (2) all the other raw materials are put into respectively in tank, after feeding intake, temperature is adjusted to 90 DEG C, mixing speed is adjusted to 50 turn/min, and each component is stirred to mix homogeneously and dissolves completely, is incubated 1 hour; (3) stir with the speed of 30 turn/min, evacuation is eliminated bubble simultaneously; (4) discharge glue, and use 100 object filter bags to filter; (5) glue is rested in the cool-bag of 88 DEG C, leave standstill 0.5 hour; (6) by the glue making on capsule manufacture equipment through dipping in glue, 50 DEG C are dry, the demoulding, trimming, fit, inspection, makes pullulan polysaccharide hollow hard capasule.
embodiment 3:
First, prepare following raw material: pulullan polysaccharide 8000g, sodium alginate 400g, glycerol 300g, ethylene glycol 50g, potassium citrate 100g, calcium chloride 10g, titanium dioxide 300g, lemon yellow 3g, water 35000g.
Then, prepare according to the following steps capsule: (1) water and all the other raw materials together put into can the heating and stirring tank of evacuation in, after feeding intake, temperature is adjusted to 85 DEG C, mixing speed is adjusted to 50 turn/min, each component is stirred to mix homogeneously and completely dissolves and form glue, be incubated 0.5 hour; (2) stir with the speed of 30 turn/min, evacuation is eliminated bubble simultaneously; (3) discharge glue, and use 100 object filter bags to filter; (4) glue is rested in the cool-bag of 50 DEG C, leave standstill 2 hours; (5) by the glue making on capsule manufacture equipment through dipping in glue, 75 DEG C are dry, the demoulding, trimming, fit, inspection, makes pullulan polysaccharide hollow hard capasule.
embodiment 4:
First, prepare following raw material: pulullan polysaccharide 9000g, Wei Lan glue 50g, carrageenan 100g, glycerol 300g, dodecyl sodium sulfate 30g, calcium propionate 80g, water 40kg.
Then, prepare according to the following steps capsule: (1) 40kg water join can the heating and stirring tank of evacuation in, allow the speed running of blender with 50 turn/min; (2) all the other raw materials are put into respectively in tank, after feeding intake, temperature is adjusted to 85 DEG C, mixing speed is adjusted to 50 turn/min, and each component is stirred to mix homogeneously and dissolves completely, is incubated 2 hours; (3) stir with the speed of 30 turn/min, evacuation is eliminated bubble simultaneously; (4) discharge glue, and use 200 object filter bags to filter; (5) glue is rested in the cool-bag of 75 DEG C, leave standstill 2 hours; (6) by the glue making on capsule manufacture equipment through dipping in glue, 50 DEG C are dry, the demoulding, trimming, fit, inspection, makes pullulan polysaccharide hollow hard capasule.
More than show and described ultimate principle of the present invention, principal character and advantage of the present invention.The technical staff of the industry should understand; the present invention is not restricted to the described embodiments; that in above-described embodiment and description, describes just illustrates principle of the present invention; without departing from the spirit and scope of the present invention; the present invention also has various changes and modifications, and these changes and improvements all fall in the claimed scope of the invention.The claimed scope of the present invention is defined by appending claims and equivalent thereof.
Claims (5)
1. pullulan polysaccharide hollow hard capasule, is characterized in that, comprises following percentage by weight component: pulullan polysaccharide 70～96%, gel 0.2～8%, flocculation aid 0.01～2%, surfactant 0～2%, wetting agent 0.2～5%, opacifier 0～3%, surplus is moisture;
Wherein:
Described gel is one or more in carrageenan, Wei Lan glue or sodium alginate;
Described flocculation aid is one or more in potassium chloride, calcium chloride, calcium propionate or potassium citrate;
Described surperficial voltinism agent is one or more in dodecyl sodium sulfate, Tween 80, sophorolipid;
Described wetting agent is one or more in glycerol, ethylene glycol, sorbitol;
Described opacifier is titanium dioxide.
2. pullulan polysaccharide hollow hard capasule as claimed in claim 1, it is characterized in that, comprise following percentage by weight component: pulullan polysaccharide 80～90%, gel 3～6%, flocculation aid 0.5～2%, surfactant 0.5～1%, wetting agent 2～3%, opacifier 0.5～2%, surplus is moisture.
3. pullulan polysaccharide hollow hard capasule as claimed in claim 1 or 2, is characterized in that, also contains the food coloring of dyeing amount.
4. the preparation method of pullulan polysaccharide hollow hard capasule as claimed in claim 1, is characterized in that, comprises the following steps:
(1) by component claimed in claim 1 and percentage by weight, with with the deionized water of 2～5 times of described component gross weights, together join can the heating and stirring tank of evacuation in, control 30～50 revs/min of speeds of agitator, 65～98 DEG C of temperature, each component is stirred to mix homogeneously and completely dissolves and form glue, be incubated 0.5～3 hour;
(2) continue to stir with the speed of 30～50 revs/min, evacuation is eliminated bubble simultaneously;
(3) discharge glue, and use 100～300 object filter bags to filter;
(4) glue of filtration is contained in cool-bag, controls 40～88 DEG C of temperature, leave standstill 0.5～3 hour;
(5) then glue, through dipping in glue, dry, the demoulding, trimming, fit, inspection, makes finished product.
5. the preparation method of pullulan polysaccharide hollow hard capasule as claimed in claim 4, is characterized in that, in step (5), baking temperature is controlled at 20～75 DEG C.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN201410218196.1A CN103961334A (en) | 2014-05-22 | 2014-05-22 | Pulullan hollow hard capsule and preparation method thereof |
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| CN201410218196.1A CN103961334A (en) | 2014-05-22 | 2014-05-22 | Pulullan hollow hard capsule and preparation method thereof |
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| CN201410218196.1A Pending CN103961334A (en) | 2014-05-22 | 2014-05-22 | Pulullan hollow hard capsule and preparation method thereof |
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Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104436204A (en) * | 2014-12-05 | 2015-03-25 | 通辽梅花生物科技有限公司 | Pullulan polysaccharide capsule and preparation process thereof |
| CN104448403A (en) * | 2014-12-05 | 2015-03-25 | 通辽梅花生物科技有限公司 | Pullulan polysaccharide gum and preparation process thereof |
| CN104840447A (en) * | 2015-06-15 | 2015-08-19 | 湖北人福药用辅料股份有限公司 | Preparation method of pulullan vacant capsules |
| CN106512077A (en) * | 2016-09-20 | 2017-03-22 | 安徽思维特生物科技有限公司 | Temperature-sensitive hemostatic gel procoagulant auxiliary prepared from gelatin |
| CN113209040A (en) * | 2021-05-13 | 2021-08-06 | 青岛益青生物科技股份有限公司 | Pullulan hollow capsule with new formula and preparation method thereof |
| US11319566B2 (en) | 2017-04-14 | 2022-05-03 | Capsugel Belgium Nv | Process for making pullulan |
| US11576870B2 (en) | 2017-04-14 | 2023-02-14 | Capsugel Belgium Nv | Pullulan capsules |
| CN115778914A (en) * | 2022-12-13 | 2023-03-14 | 江苏力凡胶囊有限公司 | Pullulan polysaccharide hollow hard capsule using low-acyl gellan gum as gel and preparation method thereof |
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| CN101069677A (en) * | 2007-06-15 | 2007-11-14 | 潮州市强基制药厂 | Pullulan polysaccharide hollow hard capasule and its preparing method |
| CN101579326A (en) * | 2008-05-13 | 2009-11-18 | 金斐嘉 | Pulullan polysaccharide empty hard capsule and preparation method thereof |
| CN102499910A (en) * | 2011-12-15 | 2012-06-20 | 山西吉呈生物技术有限公司 | Hard-shell capsule based on pullulan |
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Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104436204A (en) * | 2014-12-05 | 2015-03-25 | 通辽梅花生物科技有限公司 | Pullulan polysaccharide capsule and preparation process thereof |
| CN104448403A (en) * | 2014-12-05 | 2015-03-25 | 通辽梅花生物科技有限公司 | Pullulan polysaccharide gum and preparation process thereof |
| CN104840447A (en) * | 2015-06-15 | 2015-08-19 | 湖北人福药用辅料股份有限公司 | Preparation method of pulullan vacant capsules |
| CN106512077A (en) * | 2016-09-20 | 2017-03-22 | 安徽思维特生物科技有限公司 | Temperature-sensitive hemostatic gel procoagulant auxiliary prepared from gelatin |
| CN106512077B (en) * | 2016-09-20 | 2019-02-26 | 安徽思维特生物科技有限公司 | A kind of solidifying auxiliary agent of rush of the temperature sensitive type hemostasis gel using gelatin preparation |
| US11319566B2 (en) | 2017-04-14 | 2022-05-03 | Capsugel Belgium Nv | Process for making pullulan |
| US11576870B2 (en) | 2017-04-14 | 2023-02-14 | Capsugel Belgium Nv | Pullulan capsules |
| US11878079B2 (en) | 2017-04-14 | 2024-01-23 | Capsugel Belgium Nv | Pullulan capsules |
| CN113209040A (en) * | 2021-05-13 | 2021-08-06 | 青岛益青生物科技股份有限公司 | Pullulan hollow capsule with new formula and preparation method thereof |
| CN115778914A (en) * | 2022-12-13 | 2023-03-14 | 江苏力凡胶囊有限公司 | Pullulan polysaccharide hollow hard capsule using low-acyl gellan gum as gel and preparation method thereof |
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Application publication date: 20140806 |