CN104338144A - Dropping pill with sodium alginate and carrageenan as capsule wall material, and its production technology - Google Patents
Dropping pill with sodium alginate and carrageenan as capsule wall material, and its production technology Download PDFInfo
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- CN104338144A CN104338144A CN201310327117.6A CN201310327117A CN104338144A CN 104338144 A CN104338144 A CN 104338144A CN 201310327117 A CN201310327117 A CN 201310327117A CN 104338144 A CN104338144 A CN 104338144A
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- sodium alginate
- drop pill
- pill
- dropping
- carrageenan
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Abstract
The invention belongs to the technical field of medicine and health food products research and development, and relates to a formula and a production technology of a dropping pill based on sodium alginate. The technology comprises the following steps: 1, weighing 10.0-30.0wt% of sodium alginate, 3.0-10.0wt% of carrageenan and 2.0-4.0wt% of a plasticizer, putting the above raw materials in 70.0-85.0wt% of deionized water, and maintaining at 85DEG C for 30min to realize sodium alginate and carrageenan dissolving; 2, degassing at 85DEG C under 0.5atm for 10min, adding the obtained degassed solution into a pill dropping machine, and dropping; and 3, curing dropping pills by a composite curing agent, drying, sorting, and packaging to obtain the dropping pill. The dropping pill has the advantages of reasonable formula, safe eating, drug absorption benefiting, wide source and low price of the raw materials, simple production process, and suitableness for industrialized production.
Description
Technical field
The present invention relates to health food and pharmaceutical capsule, particularly a kind of marine source seaweed gel produces the method for medicinal drop pill.
Background technology
At present, the primary raw material that China produces drop pill is gelatin, and gelatin derives from bone and the skin of animal (pig, cattle), and its main component is protein.Once production management is not in place, just may there is the risk of affecting animals source disease, heavy metal etc. in this capsule shell.Numerous religious believers, Buddhism lay Buddhist and vegetarian cannot accept the capsule class medicine from animal.In addition because gelatin belongs to protein matter, hygroscopicity is strong, and can, the water transport absorbed to internal drug, the medicine moisture absorption be gone bad, and causes off quality short with effect duration.
Along with people are to the understanding of Thallus Laminariae (Thallus Eckloniae) capsule, and the transformation of domestic and international public's medication theory, the market demand of plant origin capsule will be made to increase rapidly.Simultaneously because Thallus Laminariae (Thallus Eckloniae) capsule does not use any gelatin, numerous Moslems patient can take in relieved powder charge, and product can export to vast Islam and kosher area, will earn foreign exchange, and improve the economic benefit of enterprise for country.
Sodium alginate is a kind of polysaccharide carbohydrate extracted from the Thallus Laminariae (Thallus Eckloniae) or Alga Sgrgassi Enerves of Brown algae, rely on 1 by by α-L-mannuronic acid (M unit) and β-D-guluronic acid (G unit), 4-glycosidic bond connects and the copolymer be made up of GM, MM and GG fragment of different proportion, the one in alginic acid derivative, so sometimes also claim sodium alginate or seaweed gel and alginate jelly.Sodium alginate with its good biological degradability and biocompatibility, and is widely used in the fields such as chemistry, biology, medicine, food.
Summary of the invention
The object of the present invention is to provide a kind of marine source seaweed gel to produce to have that extensibility, tension force are strong, the method for the good medicinal drop pill of toughness.
The technical solution adopted for the present invention to solve the technical problems is: the film forming raw material of drop pill contains major ingredient and multiple auxiliary materials mixture, major ingredient contains sodium alginate, carrageenan, adjuvant contains plasticizer, water, also can additionally increase certain additive according to product needed, as antiseptic, aromatic and coloring agent etc.
1, the formula following (below all by weight percentage) of the marine source seaweed gel drop pill of the present invention:
Hydrophilic gel: the sodium alginate of 20.0%, the carrageenan of 6.0%
Correctives, screening agent: the bourbonal,ethyl vanillin of 0.1%, the titanium dioxide of 0.2%
Plasticizer: glycerol, sorbitol or xylitol
Water content 13-15% in product
2, the production technology of the marine source seaweed gel drop pill of the present invention is carried out in accordance with the following steps:
(1) colloidal sol, insulation:
Pure water and plasticizer mixed and is heated to 80 DEG C, slowly the pressed powder weighed up being added until form clear solution under constantly stirring, then in dislocation interlayer steam cooker, at 85 DEG C of heating 20min, making it to dissolve uniformly glue.Use filter cloth (150 order) to filter into dipping in (with water bath heat preservation) in glue pot again, degassed standing 10min under 0.5atm at 85 DEG C, makes glue clarify for subsequent use.
(2) dripping, solidification:
Glue is poured in the glue groove of drop pill experiment dripping machine, keep 85 DEG C.Setting firming agent temperature is 15 ~ 20 DEG C, and the velocity ratio of glue and medicinal liquid is between 1:2 ~ 4, and controls total flow.Enable soft gelatin capsule smoothly by firming agent interface and adhesion.Drop pill hardening time in lower floor's firming agent is 1 ~ 10 minute.
(3) dry, arrangement:
The drop pill solidified is positioned over 50 DEG C, dries 1 ~ 2 hour in the climatic chamber of relative humidity 30-40%.Substandard products in capsule after oven dry, waste product are chosen and picked.And by capsule splendid attire in hermetic container, constant humidity is stored in shady and cool dry place, is finished product after packaging.
specific embodiments:
The preparation technology of a kind of marine source seaweed gel drop pill of the present invention comprises following examples, and the following examples can further illustrate the present invention, but do not limit the present invention in any way.
embodiment 1, the present invention the formula for a product (consisting of by weight percentage) of marine source seaweed gel drop pill: the sodium alginate of 20.0%, the carrageenan of 6.0%, 8.0% sorbitol and glycerol, the distilled water of 65.0% and the auxiliary agent of 1%; Drop pill fabrication processing is: mixed with the plasticizer of 8.0% by the distilled water of 65.0% and be heated to 85 DEG C, slowly the epoxy glue of the sodium alginate of weigh up 20.0%, the carrageenan of 6.0% is added until form clear solution under constantly stirring, in rear dislocation interlayer steam cooker, at 85 DEG C of heating 20min, make it to dissolve uniformly glue.Using filter cloth (150 order) to filter into dipping in (with water bath heat preservation) in glue pot again, under 85 DEG C of 0.5 atm after degassed 10min, naturally removing the foam on liquid level.Poured into by the glue configured in the glue groove of drop pill experiment dripping machine, setting firming agent temperature is 15 ~ 20 DEG C, and the velocity ratio of glue and medicinal liquid is between 1:2 ~ 4, and controls total flow and carry out dripping.The drop pill solidified is positioned over 50 DEG C, dries 1 hour in the climatic chamber of relative humidity 30-40%.Substandard products in capsule after oven dry, waste product are chosen and picked.And by capsule splendid attire in hermetic container, constant humidity is stored in shady and cool dry place, namely obtains product of the present invention after packaging.
embodiment 2, the present invention the formula for a product (consisting of by weight percentage) of marine source seaweed gel drop pill: the sodium alginate of 16.0%, the carrageenan of 8.0%, the xylitol of 8%, the distilled water of 67% and 1% auxiliary agent; Capsule fabrication processing is: mixed with the plasticizer of 8% by the distilled water of 67% and be heated to 85 DEG C, slowly the mixture of the sodium alginate of weigh up 16.0%, the carrageenan of 8.0% is added until form clear solution under constantly stirring, in rear dislocation interlayer steam cooker, at 85 DEG C of heating 20min, make it to dissolve uniformly glue.Using filter cloth (150 order) to filter into dipping in (with water bath heat preservation) in glue pot again, under 85 DEG C of 0.5 atm after degassed 10min, naturally removing the foam on liquid level.Poured into by the glue configured in the glue groove of drop pill experiment dripping machine, setting firming agent temperature is 15 ~ 20 DEG C, and the velocity ratio of glue and medicinal liquid is between 1:2 ~ 4, and controls total flow and carry out dripping.The drop pill solidified is positioned over 50 DEG C, dries 1 hour in the climatic chamber of relative humidity 30-40%.Substandard products in capsule after oven dry, waste product are chosen and picked.And by capsule splendid attire in hermetic container, constant humidity is stored in shady and cool dry place, namely obtains product of the present invention after packaging.
Claims (5)
1. a sodium alginate is the drop pill of primary raw material, it is characterized in that: take sodium alginate, the carrageenan of 3.0-10.0%, the plasticizer of 2.0-4.0% that percentage by weight is 10.0-30.0%, put into the deionized water of 70.0-85.0%, keep carrying out colloidal sol in 30 minutes at 85 DEG C; Under 85 DEG C of 0.5atm degassed 10 minutes, then add pill dripping machine and carry out dripping; Drop pill composite curing agent is cured, then dry, arrange, after packaging and other steps and get final product.
2. the sodium alginate according to claims 1 is the drop pill production method of primary raw material, it is characterized in that: described colloidal sol, incubation step are for heat 80 DEG C by pure water and plasticizer, slowly the pressed powder weighed up is added until form clear solution under constantly stirring, then in dislocation interlayer steam cooker, at 85 DEG C of heating 30min, make it to dissolve uniformly glue, then use filter cloth (150 order) to filter into dipping in (with water bath heat preservation) in glue pot, under 85 DEG C of 0.5atm degassed 10 minutes; Then add pill dripping machine and carry out dripping, drop pill composite curing agent is cured, dry, arrangement.
3. the sodium alginate according to claims 2 is the drop pill production method of primary raw material, it is characterized in that: be positioned over 50 DEG C through the drop pill of overcuring, dry 1 ~ 2 hour in the baking oven of relative humidity 30-40%.
4. the sodium alginate according to claims 2 is the drop pill production method of primary raw material, it is characterized in that: described composite curing agent solidification: firming agent is made up of two parts, top is organic facies, for by but be not limited to vegetable oil, paraffin oil, methyl-silicone oil form, bottom for by but be not limited to Ca
2+, Mg
2+, Al
3+, Zn
2+deng the curing agent solution of cation composition, total concentration is 1.5 ~ 4.5%.
5. the sodium alginate according to claims 2 is the drop pill production method of primary raw material, it is characterized in that: described batching, colloidal sol, insulation, solidification, drying, arrangement, packaging should be carried out in 300,000 grades of clean rooms.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310327117.6A CN104338144A (en) | 2013-07-31 | 2013-07-31 | Dropping pill with sodium alginate and carrageenan as capsule wall material, and its production technology |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201310327117.6A CN104338144A (en) | 2013-07-31 | 2013-07-31 | Dropping pill with sodium alginate and carrageenan as capsule wall material, and its production technology |
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| CN104338144A true CN104338144A (en) | 2015-02-11 |
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| CN201310327117.6A Pending CN104338144A (en) | 2013-07-31 | 2013-07-31 | Dropping pill with sodium alginate and carrageenan as capsule wall material, and its production technology |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114404383A (en) * | 2022-02-24 | 2022-04-29 | 南京健辉生物科技有限公司 | Plant soft capsule and preparation method thereof |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102657869A (en) * | 2012-05-25 | 2012-09-12 | 无锡福尔顺科技有限公司 | Alginate hard capsule disintegrable at different positions in gastrointestinal tract |
| CN103006616A (en) * | 2013-01-04 | 2013-04-03 | 山东大学（威海） | Algal polysaccharide capsules and method for manufacturing same |
| CN103041397A (en) * | 2013-01-04 | 2013-04-17 | 山东大学（威海） | Sodium alga acid capsule and production process thereof |
| CN103100091A (en) * | 2013-01-04 | 2013-05-15 | 山东大学（威海） | Compound seaweed gum and application thereof to capsule preparation |
| CN103100090A (en) * | 2013-01-04 | 2013-05-15 | 山东大学（威海） | Hard capsule shell material and production process thereof |
| CN103127519A (en) * | 2013-01-04 | 2013-06-05 | 山东大学（威海） | Sea-tangle glue capsule membrane material and manufacturing process thereof |
-
2013
- 2013-07-31 CN CN201310327117.6A patent/CN104338144A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102657869A (en) * | 2012-05-25 | 2012-09-12 | 无锡福尔顺科技有限公司 | Alginate hard capsule disintegrable at different positions in gastrointestinal tract |
| CN103006616A (en) * | 2013-01-04 | 2013-04-03 | 山东大学（威海） | Algal polysaccharide capsules and method for manufacturing same |
| CN103041397A (en) * | 2013-01-04 | 2013-04-17 | 山东大学（威海） | Sodium alga acid capsule and production process thereof |
| CN103100091A (en) * | 2013-01-04 | 2013-05-15 | 山东大学（威海） | Compound seaweed gum and application thereof to capsule preparation |
| CN103100090A (en) * | 2013-01-04 | 2013-05-15 | 山东大学（威海） | Hard capsule shell material and production process thereof |
| CN103127519A (en) * | 2013-01-04 | 2013-06-05 | 山东大学（威海） | Sea-tangle glue capsule membrane material and manufacturing process thereof |
Non-Patent Citations (1)
| Title |
|---|
| 李亚琴等: "《药物制剂工程》", 30 September 2008 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114404383A (en) * | 2022-02-24 | 2022-04-29 | 南京健辉生物科技有限公司 | Plant soft capsule and preparation method thereof |
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