CN101606919A - Produce the method for medical capsule shells with carrageenan - Google Patents
Produce the method for medical capsule shells with carrageenan Download PDFInfo
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- CN101606919A CN101606919A CNA2008101234608A CN200810123460A CN101606919A CN 101606919 A CN101606919 A CN 101606919A CN A2008101234608 A CNA2008101234608 A CN A2008101234608A CN 200810123460 A CN200810123460 A CN 200810123460A CN 101606919 A CN101606919 A CN 101606919A
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- carrageenan
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Abstract
The present invention relates to a kind of method of producing medical capsule shells with carrageenan, the film forming raw material of capsule shells contains the k-carrageenan, the i-carrageenan, swelling agent, plasticizer, water and certain additive, after above-mentioned capsule film forming raw material is pressed the constituent content weighing, the all solids component is placed on the container for stirring mix homogeneously, the branch of liquid comprises that plasticizer and water are placed in another container or directly put agitating device into and mixes, and after being heated to about 80 ℃ simultaneously, again solid constituent behind the mixing and liquid component are added in the full-automatic hollow capsule maker, heat again, stir, do not have till the granule fully, its heating-up temperature preferably is not higher than 96 ℃, is processed into the capsule shells finished product by the full-automatic hollow capsule maker then.Since adopt carrageenan as base material production capsule shells, abundant raw material, and cost is lower; Because used carrageenan is opened non-single kind type, the gel strength of existing k type carrageenan has i type carrageenan elasticity again, can reduce the use of other gels, and product quality is guaranteed.
Description
Technical field
The present invention relates to health food and pharmaceutical capsule, particularly a kind of method of producing medical capsule shells with carrageenan.
Background technology
In the past, producing capsular primary raw material was gelatin, and gelatin is normally with bone, the skin of animal and conclude tissue to concentrate the collagen protein that the back obtains through hydrolysis made.
Adopting carrageenan to produce capsule for medicine is the new industry of 21st century.At China's carrageenan except that having the more application at food, aspect medical, daily-use chemical industry, biochemistry, building coating, textile printing and dyeing and agriculture aspect in the field purposes also very extensive.Carrageenan mainly is the natural macromolecule amylose hydrophilic gel material that extracts the kind Sargassums such as Chondrus, Eucheuma, China fir Trentepohlia and husky Lepidium from red algae, difference according to sulfuric acid ester group on its galactose residue is divided into k-carrageenan (Kappa-Carraginan), i---carrageenan (Iota---Carraginan), lambda-carrageenan polytypes such as (Landa--Carraginan), wherein, k-carrageenan and i-carrageenan can form colloid, the k-carrageenan is more frangible, but intensity is better; And being easy to calcium ion, the i-carrageenan forms a kind of more weak rubber-like colloid.For the i-carrageenan, k-carrageenan cost is lower, so utilization contains the k-carrageenan and i-carrageenan compositions is effective for base material forms colloid membrane, also have the capsule of manufacturing the most basic needed ductility, sealing, elasticity, tensile strength condition, wherein contain the film forming component height, provide required physical features for making capsule.
Summary of the invention
The object of the present invention is to provide a kind of with carrageenan production have that extensibility, tension force are strong, the toughness method of medical capsule shells preferably.
The technical solution adopted for the present invention to solve the technical problems is: the film forming raw material of capsule shells contains major ingredient and multiple adjuvant mixture, major ingredient contains k-carrageenan and i-carrageenan, adjuvant contains swelling agent, plasticizer, water, also can additionally increase certain additive according to product needed, as opacifier, opalizer, antiseptic, aromatic and coloring agent etc., its constituent content (by weight percentage) is:
K--carrageenan 1---15
I-carrageenan 1---20
Swelling agent 8---60
Plasticizer 8---40
Water 15---75
Additive＜5
The preferable constituent content (by weight percentage) of the film forming raw material of capsule shells is:
K-carrageenan 0.5---8
I-carrageenan 2---10
Swelling agent 15---50
Plasticizer 15---35
Water 25---60
Additive＜2
After the film forming raw material of above-mentioned capsule is pressed the constituent content weighing,, comprise that k-carrageenan, i-carrageenan and one or more swelling agents are placed on the container for stirring mix homogeneously with the component of all solids; The component of liquid, comprising that plasticizer and water are placed in another container or directly put agitating device into mixes, and after being heated to about 80 ℃ simultaneously, component with solid constituent behind the mixing and liquid adds in the full-automatic hollow capsule maker again, heats, stirs, does not have till the granule fully.Its heating-up temperature preferably is not higher than 96 ℃, is processed into the capsule shells finished product by the full-automatic hollow capsule maker then, or becomes diaphragm, band shape, tube.
Above described swelling agent, can increase the solids content of film forming mixture, when making capsule housing, help to save film forming drying time, comparatively ideal swelling agent is the low-viscosity modified starch, can increase into the viscosity of glue mixture, helpful to its formed film strength and adaptation, cured matter corn starch as upgrading, and added the octenyl sodium succinate starch that forms after the corn syrup solids, also just like modified pregelatinized starch, guar gum, arabic gum, locust bean gum etc.
Plasticizer is the starch esterification product mostly, can increase the ductility and the adaptation of film forming mixture, when material is incapsulated, makes seam tightr tough and tensile, not cracky.Plasticizer has glycerol, noncrystalline mannitol, Polyethylene Glycol, Sorbitol and maltose alcohol etc., plasticizer preferably, can be mixed and made into by amorphous state Sorbitol and maltose alcohol, cause the capsule phenomenon of blooming because of general Sorbitol can produce crystallization at the capsule memory period on its surface.
Water will be selected distilled water for use, preferably selects the distilled water that purified for use.
Other additives such as coloring agent titanium white powder pigment (TiO
2Though) waiting the characteristic that can not change the film forming mixture, the weight of adding had better not surpass 2% of mixture total weight amount.
Cause is medicine or health food capsule shells, the above-mentioned raw materials used state food level quality standard that all will meet.
The present invention has following advantage: since adopt be not expensive carrageenan as base material production capsule shells, raw material resources are abundant, edible nontoxic, cost is lower, economic benefit is preferable; Because carrageenan is not the single kind type, existing k type carrageenan can increase the gel strength of hydrocolloid film, the elasticity and the toughness that have i type carrageenan to be had again, can reduce the use of other gels, than animal bone, skin is that the gelatine capsule shell effect made of raw material is good, and product quality is guaranteed.
The specific embodiment
Processing technology routine:
→ stirring, mixing, heating → full-automatic hollow capsule maker → finished product
Embodiment 1
The raw material consumption: all raw materials all meet state food level quality standard, and carrageenan is a capsule special food level.
K-carrageenan 1kg; I-carrageenan 1kg; Upgrading corn starch 11kg; Sorbitol 15kg; Distilled water 22kg.
Operating procedure: after accurately taking by weighing the above-mentioned raw materials consumption by technological requirement, k-carrageenan, i-carrageenan and upgrading corn starch are progressively poured in the container that agitating device is housed, carried out uniform mixing; Again Sorbitol and distilled water are poured into another container or directly put agitating device into and stir, be heated to simultaneously about 80 ℃, again that the uniform mixing of agitating device is good solid mixture and liquid mixture are added in the full-automatic hollow capsule maker at leisure, these facility have automatic stirring and heating function, stir once again, and be heated to about 90 ℃, up to granule dissolve fully become sliding along till, just produce qualified carrageenan capsule shell finished product then.
Embodiment 2
The raw material consumption: all raw materials all meet state food level quality standard, and carrageenan is a capsule special food level.
K-carrageenan 0.5kg; I-carrageenan 1.5kg; Upgrading corn starch 10kg; Sorbitol 12kg; Maltose alcohol 6kg; Distilled water 19.5kg, titanium dioxide 0.5kg.
Operating procedure: after accurately taking by weighing the above-mentioned raw materials consumption by technological requirement, k-carrageenan, i-carrageenan, upgrading corn starch and titanium dioxide are progressively poured in the container that agitating device is housed, carry out uniform mixing after; Again Sorbitol, maltose alcohol and distilled water are poured into other-individual container or directly put in the agitating device, carry out again being heated to about 80 ℃ while stirring, again that the uniform mixing of agitating device is good solid mixture and liquid mixture are added in the full-automatic hollow capsule maker at leisure, stir once again, and be heated to about 90 ℃, up to granule dissolve fully become sliding along till, just produce qualified carrageenan capsule shell finished product then.
Claims (4)
1, a kind of method of producing medical capsule shells with carrageenan, the film forming raw material of capsule shells contains major ingredient and multiple adjuvant mixture, major ingredient contains k-carrageenan and i-carrageenan, adjuvant contains swelling agent, plasticizer, water, also contain additive opacifier, opalizer, antiseptic, aromatic and coloring agent, it is characterized in that: constituent content (by weight percentage) is:
K--carrageenan 1---15
I-carrageenan 1---20
Swelling agent 8---60
Plasticizer 8---40
Water 15---75
Additive＜5
After the film forming raw material of above-mentioned capsule is pressed the constituent content weighing,, comprise that k-carrageenan, i-carrageenan and one or more swelling agents are placed on the container for stirring mix homogeneously with the component of all solids; The component of liquid, comprising that plasticizer and water are placed in another container or directly put agitating device into mixes, and after being heated to about 80 ℃ simultaneously, component with solid constituent behind the mixing and liquid adds in the full-automatic hollow capsule maker again, heat again, stir, do not have fully till the granule, its heating-up temperature preferably is not higher than 96 ℃, is processed into the capsule shells finished product by the full-automatic hollow capsule maker then.
2, a kind of method of producing medical capsule shells according to claim 1 with carrageenan, it is characterized in that: preferable constituent content (by weight percentage) is:
K-carrageenan 0.5---8
I-carrageenan 2---10
Swelling agent 15---50
Plasticizer 15---35
Water 25---60
Additive＜2
3, a kind of method of producing medical capsule shells with carrageenan according to claim 1, it is characterized in that: swelling agent is the low-viscosity modified starch.
4, a kind of method of producing medical capsule shells with carrageenan according to claim 1, it is characterized in that: plasticizer is the starch esterification product.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2008101234608A CN101606919A (en) | 2008-06-21 | 2008-06-21 | Produce the method for medical capsule shells with carrageenan |
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|---|---|---|---|
| CNA2008101234608A CN101606919A (en) | 2008-06-21 | 2008-06-21 | Produce the method for medical capsule shells with carrageenan |
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| CN101606919A true CN101606919A (en) | 2009-12-23 |
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| CNA2008101234608A Pending CN101606919A (en) | 2008-06-21 | 2008-06-21 | Produce the method for medical capsule shells with carrageenan |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102100681A (en) * | 2011-01-28 | 2011-06-22 | 广东仙乐制药有限公司 | Vegetal shell of soft capsule |
| CN102342509A (en) * | 2011-09-15 | 2012-02-08 | 山东商业职业技术学院 | Konjak polysaccharide compound soft capsule shell and preparation method thereof |
| CN103191433A (en) * | 2013-03-28 | 2013-07-10 | 姜晓东 | Safe hollow capsules using plant starch as raw material and preparation process thereof |
| CN103948561A (en) * | 2014-01-08 | 2014-07-30 | 天津科技大学 | High-calcium plant-derived hollow capsule and preparation method and application thereof |
| CN107072958A (en) * | 2014-09-25 | 2017-08-18 | 科丝美诗生物有限公司 | Autonomic soft capsules composition not comprising Chemical metal salt |
| CN112998112A (en) * | 2021-04-13 | 2021-06-22 | 浙江新维士生物科技有限公司 | Non-animal gum soft sweet and preparation method thereof |
| CN113180136A (en) * | 2021-04-13 | 2021-07-30 | 浙江新维士生物科技有限公司 | Preparation method of gel soft sweets |
-
2008
- 2008-06-21 CN CNA2008101234608A patent/CN101606919A/en active Pending
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102100681A (en) * | 2011-01-28 | 2011-06-22 | 广东仙乐制药有限公司 | Vegetal shell of soft capsule |
| CN102100681B (en) * | 2011-01-28 | 2012-07-25 | 广东仙乐制药有限公司 | Vegetal shell of soft capsule |
| CN102342509A (en) * | 2011-09-15 | 2012-02-08 | 山东商业职业技术学院 | Konjak polysaccharide compound soft capsule shell and preparation method thereof |
| CN102342509B (en) * | 2011-09-15 | 2013-04-24 | 山东商业职业技术学院 | Konjak polysaccharide compound soft capsule shell and preparation method thereof |
| CN103191433A (en) * | 2013-03-28 | 2013-07-10 | 姜晓东 | Safe hollow capsules using plant starch as raw material and preparation process thereof |
| CN103948561A (en) * | 2014-01-08 | 2014-07-30 | 天津科技大学 | High-calcium plant-derived hollow capsule and preparation method and application thereof |
| CN107072958A (en) * | 2014-09-25 | 2017-08-18 | 科丝美诗生物有限公司 | Autonomic soft capsules composition not comprising Chemical metal salt |
| CN107072958B (en) * | 2014-09-25 | 2021-08-13 | 科丝美诗生物有限公司 | Soft botanical capsule composition without chemical metal salts |
| CN112998112A (en) * | 2021-04-13 | 2021-06-22 | 浙江新维士生物科技有限公司 | Non-animal gum soft sweet and preparation method thereof |
| CN113180136A (en) * | 2021-04-13 | 2021-07-30 | 浙江新维士生物科技有限公司 | Preparation method of gel soft sweets |
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Open date: 20091223 |