CN107712894A - A kind of algin is the preparation method of the norcholesterol soft capsule preparation of capsule material - Google Patents
A kind of algin is the preparation method of the norcholesterol soft capsule preparation of capsule material Download PDFInfo
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- CN107712894A CN107712894A CN201710970047.4A CN201710970047A CN107712894A CN 107712894 A CN107712894 A CN 107712894A CN 201710970047 A CN201710970047 A CN 201710970047A CN 107712894 A CN107712894 A CN 107712894A
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- capsule
- extract
- red ginseng
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- OYHQOLUKZRVURQ-IXWMQOLASA-N linoleic acid Natural products CCCCC\C=C/C\C=C\CCCCCCCC(O)=O OYHQOLUKZRVURQ-IXWMQOLASA-N 0.000 description 1
- 229960004488 linolenic acid Drugs 0.000 description 1
- KQQKGWQCNNTQJW-UHFFFAOYSA-N linolenic acid Natural products CC=CCCC=CCC=CCCCCCCCC(O)=O KQQKGWQCNNTQJW-UHFFFAOYSA-N 0.000 description 1
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- 150000003431 steroids Chemical class 0.000 description 1
- 239000004575 stone Substances 0.000 description 1
- 239000000375 suspending agent Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 230000002194 synthesizing effect Effects 0.000 description 1
- WBWWGRHZICKQGZ-HZAMXZRMSA-N taurocholic acid Chemical compound C([C@H]1C[C@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(=O)NCCS(O)(=O)=O)C)[C@@]2(C)[C@@H](O)C1 WBWWGRHZICKQGZ-HZAMXZRMSA-N 0.000 description 1
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- 239000002562 thickening agent Substances 0.000 description 1
- 230000035922 thirst Effects 0.000 description 1
- 201000002510 thyroid cancer Diseases 0.000 description 1
- 210000001685 thyroid gland Anatomy 0.000 description 1
- 239000003440 toxic substance Substances 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 230000032258 transport Effects 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 239000001917 trigonella foenum graecum l. absolute Substances 0.000 description 1
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- 150000004670 unsaturated fatty acids Chemical class 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L17/00—Food-from-the-sea products; Fish products; Fish meal; Fish-egg substitutes; Preparation or treatment thereof
- A23L17/60—Edible seaweed
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
- A23L29/20—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents
- A23L29/206—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents of vegetable origin
- A23L29/256—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents of vegetable origin from seaweeds, e.g. alginates, agar or carrageenan
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
- A23L29/30—Foods or foodstuffs containing additives; Preparation or treatment thereof containing carbohydrate syrups; containing sugars; containing sugar alcohols, e.g. xylitol; containing starch hydrolysates, e.g. dextrin
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
- A23P10/00—Shaping or working of foodstuffs characterised by the products
- A23P10/30—Encapsulation of particles, e.g. foodstuff additives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Abstract
Health food belonging to the present invention researchs and develops technical field.A kind of preparation method the present invention relates to algin for the norcholesterol soft capsule preparation of capsule material.Capsule material supplementary material composition is agar, trigonella bean gum, sodium alginate, bourbonal,ethyl vanillin, titanium dioxide, glycerine, sorbierite or xylitol；Lactobacillus-fermented Korean red ginseng extract and pen shell shellfish micron powder and seaweed, sea are accumulate and mixed with the water extract of jujube, as capsule core material；Capsule material supplementary material is put into deionized water, keeps carrying out colloidal sol in 30 minutes；Deaerated 10 12 minutes under 0.5 vacuum, turn into capsule material glue；By capsule material glue glue piece, capsule core material is added, soft capsule preparation is prepared by pressing.Product capsule material of the present invention has the characteristics of strong extensibility, tension force, good toughness；Soft capsule preparation has norcholesterol, improves the function of immunity of organisms and anticancer adjuvant.
Description
Technical field：
Health food belonging to the present invention researchs and develops technical field.Consolidate the present invention relates to a kind of algin for the drop courage of capsule material
The preparation method of alcohol soft capasule preparation.Product capsule material of the present invention has the characteristics of strong extensibility, tension force, good toughness；Soft capsule system
Agent has norcholesterol, improves the function of immunity of organisms and anticancer adjuvant.
Background technology：
Soft capsule (Soft Capsule) has turned into current clinical practice most widely medicinal system since nineteen thirty-five comes out
One of agent.Many oilies, liquid even paste raw materials medicine can be processed into soft capsule.All kinds of flexible glues that countries in the world have listed
Capsule preparation is up to hundreds of, including VE soft capsules, oenothera biennis soft capsule, polyenoid caring soft capsule, deep-sea fish oil soft capsules etc.
Conventional kind and panoramic health-care preparation soft capsule (such as cod-liver oil soft capsule, sabal fat capsule).It is soft
Capsule is primary raw material using pharmagel as hard shell capsules.Gelatin after animal slaughtering byproduct (mainly pig,
Ox, sheep bone and pigskin and ox-hide).But Britain is bright so as to feed through to there occurs world-shaking rabid ox disease event since the nineties
Glue market.Because European's eating beef, therefore ox bone and ox-hide are the primary raw materials of European Gelatin Industry.Because the public is to crazy ox
With panic, some environmental protection organizations (such as green peace organization) start to resist the gelatin from ox byproduct the generally worry of disease.With
This simultaneously, the national requirements import gelatin being a Moslem must be (can not being carried doped with pigskin and pig bone for " Islamic "
The gelatin taken).But for manufacturing of gelatin factory, one is deposited in because the Animal Bone purchased from various regions mixes mostly
Rise, it is difficult to thoroughly separate, therefore require that the raw material of production gelatin definitely meets " Islamic " requirement and I'm afraid that operation difficulty is larger.This
In the case of, some Islam also resist the import of soft-gelatin capsule preparation.This just makes to traditional soft capsule preparation industry
Into great impact.Find the gelatin substitute products of non-animal turns into the task of top priority as soft capsule auxiliary material.Additionally due to
Gelatin belongs to protein matter, and hygroscopicity is strong, and the medicine moisture absorption can be made to go bad, led the water transport of absorption to internal drug
Cause the off quality and term of validity short.
Agar, scientific name agar-agar, English name (agar), also known as agar (agar-agar), agar-agar, agar-agar, are natural plant gum
One kind, the Eucheumas of conventional marine products, agar, fragrant plant mentioned in ancient texts etc. is made, and is solid colourless, without solid shape, is dissolved in hot water.Eating
It is widely used in product industry, is also commonly used for bacteria culture media.
Agar is the polysaccharide body by being extracted in marine alga, is current one of widest algin of purposes in the world.It is eating
Many aspects such as product industry, medical industry, daily-use chemical industry, bioengineering have a wide range of applications, and agar is used for can be bright in food
The aobvious quality for changing food, improve the class of food.Price is very high.Its feature：With coagulability, stability can be with some things
Matter forms the physicochemical properties such as complex compound, can be used as thickener, coagulator, suspending agent, emulsifying agent, antistaling agent and stabilizer.
It is widely used in manufacture orange granule juice and various beverages, jelly, ice cream, cake, soft sweets, can, meat products, mixed congee, white fungus swallow
Nest, custard based food, stir-fried food etc. agar medical research, can make culture medium, ointment base and other purposes in chemical industry.
The agar made of algae is translucent, unbodied powder, thin slice or particle.Processing is mainly distributed on mountain
There is processing east, Liaoning, Guangdong each province.Agar profile has several not homomorphs such as slice, strip, thin slice, fritter, with thin
Bar is preferred.The external place of production is Japan, Korea, New Zealand, the U.S. and Russia.Agar does not dissolve in cold water, can absorb quite in itself
The water that 20 times of volume.Boiling water is soluble in, dilution still keeps liquid at 42 DEG C (108 °F), but congeals into close jelly at 37 DEG C.
Agar is the constituent of cell membrane, contains complicated carbohydrate, calcium and sulfate.
The most useful characteristic of agar is that the temperature difference between its condensation point and fusing point is very big.It needs to be heated to 95 in water
DEG C when just start to melt, just start to solidify when the solution temperature after fusing need to drop to 40 DEG C, thus it be prepare solid medium
Best coagulator.The solid medium prepared with agar, is used for high-temperature cultivation and non-fusible, is inoculated with before curing
When, culture will not also be scalded dead.Therefore, agar is to prepare most widely used a kind of coagulator in various biological mediums.
The 1~1.5% of the concentration of agar, typically fluid nutrient medium.
Trigonella bean gum (fenugreek gum), Trigonella foenum-graecum scientific name faenum graecum, it is annual herb legume, can divides from Trigonella foenum-graecum
From extraction fenugreek gum.Fenugreek gum is that (fenugreek gum is a kind of excellent aqueous gel of domestic-developed to a kind of natural plant gum newly developed
Type fracturing fluid gelatinizer), predominantly pure natural galactomannans composition.It is a kind of galactomannans class natural plant gum,
With preferable water-soluble and bridging property, there is unique rheological characteristic, i.e., can be formed at low concentrations it is highly viscous stablize it is water-soluble
Liquid.Galactomannan gum is widely used, and someone's research shows that galactose side is than main chain sweet dew in galactomannan molecule
Glycosyl is more easy to form complex compound with boron ion, in the contrast of 5 kinds of polysaccharide adhesivenesses of progress, finds fenugreek galactomannans
Middle galactose content is maximum, adhesiveness highest.Combination of fenugreek gum (wherein more than 60% is galactomannans) is widely used in stone
Oil exploitation, printing and dyeing sizing etc..Containing more than 8% grease and abundant protein in plumule cotyledon, contain 2.7% in grease
Unsaponifiable matter, unsaturated fatty acid content is up to 84.91%, wherein mainly linoleic acid plus linolenic acid, value are very high.Hu Lu
Graecum seed contains 0.7%~1.2% steroid sapogenines, wherein mainly Diosgenin, remaining from the seed after separation gel
Extracted in thing, fenugreek diosgenin can be obtained.Diosgenin is the main crude drug of synthesizing steroid hormone, and synthesis is orally kept away
The main production raw material of pregnant medicine, therefore diosgenin plays a very important role in terms of human health prenatal and postnatal care is ensured.
In addition, fenugreek seed also contains lecithin, choline, trigonelline etc., so fenugreek is both the medicinal of a variety of diseases for the treatment of
Plant, it is excellent raw material of industry plant newly developed again.Belong to rare traditional Chinese medicine, with the development of science and technology and process technology
Raising, faenum graecum whole body is that the function of " treasured " embodies further, and its development field is wide, application is big, economic value is high.
Can be widely applied to oil fracturing, ore dressing mining, textile printing and dyeing, health food, system perfume, powder of lacquer putty for use on, daily-use chemical industry,
The industries such as medicine, plant extract, cosmetics, feed.
By the change such as measure and analytical concentration, shearing force, temperature, pH and freeze thawing to trigonella bean gum solution apparent viscosity
Influence and the synergistic with the foodstuff glue such as xanthans, the rheological characteristic of trigonella bean gum solution is studied.Result of study shows：
Cold water is molten and apparent viscosity all exponentially risings of rule with the rise of concentration of the molten trigonella bean gum solution of hot water；Trigonella bean gum
Solution is non-newtonian fluid, and its shear thinning has instantaneous recovery；With the rise of temperature, the apparent of trigonella bean gum solution is glued
Degree declines in semilog rule；And solution has very strong heat resistance；Trigonella bean gum solution under acid and alkalescence condition more
It is stable；Freeze thawing treatment can decline the apparent viscosity of trigonella bean gum solution；Trigonella bean gum has certain with xanthans, sodium alginate
Synergistic.
Sodium alginate is a kind of polysaccharide carbohydrate extracted from the sea-tangle or sargassum of brown algae, is by by α-L-
Mannuronic acid (M units) is with β-D- guluronic acids (G units) by Isosorbide-5-Nitrae-glucosides key connection and by GM, MM of different proportion
It is one kind in alginic acid derivative, so sometimes referred to as sodium alginate or seaweed gel and sea with the copolymer of GG fragments composition
Phycocolloid.Sodium alginate is widely used in chemistry, biology, medicine, food with its good biological degradability and biocompatibility
The fields such as product.
With understanding of the people to plant capsule, and the transformation of public's medication theory both at home and abroad, it will make plant origin
The market demand of capsule increases rapidly.Simultaneously because plant capsule can trust without using any gelatin, numerous Moslems patient
Powder charge is taken, and product can export to vast Islam and kosher area, will be earned foreign exchange for country, and improve enterprise
Economic benefit.
1 Korean red ginseng is process by the fresh ginseng in the Koryo for originating from South Korea through steaming, toasting, in processing Korean red ginseng process
In, there is new anticancer active constituent to produce.Korean red ginseng is not not cool also warm, belongs to warm nature；Though Korean ginseng is warm-natured but benefit property is strong, benefit
Gas helps fire.Korean ginseng divides white ginseng and red ginseng again, and insufficiency of the spleen hyperactivity of fire person preferably uses white ginseng, because of " life gas is cool, slight bitter tonifying yin "；Insufficiency of the spleen lung is timid
Person preferably uses red ginseng, " ripe to use temperature, sweet yang-tonifying ".On the whole, Korean ginseng is more suitable for the frank people of the old deficiency of vital energy and taken,
The strong constitution of energy, strengthen immunity.
The effect of Korean red ginseng：
(1) brain healthy：The people that declines to failure of memory and sports coordination ability and it is on the drink or contact with second
The food of alcohol composition, the people of medicine, Korean red ginseng, which has to improve mental working ability, enhancing memory and improve cerebral ischemia, to be hindered
The effect of hindering
(2) ease pain：Some experts by do sensory nerve cell experiment find, Korean ginseng to the various pain symptoms of body all
It is helpful.
(3) anti-cancer and anticancer：The saponin constituent of Korean red ginseng and non-saponin constituent have the propagation for suppressing a variety of cancer cells to live
Property, while can also suppress cancer metastasis.In addition, Korean red ginseng is taken together with anticancer, anticancer effect is better than individually with anti-
Cancer agent (mitomycin).Because cancer cell easily forms tolerance in chemotherapy of tumors, Korean red ginseng, with taking, strengthens with anticancer
The side effect of lethality, mitigation anticancer to cancer cell.
(4) strengthen immunity：Korean red ginseng extract can recover that (mitogen is mould because taking the anticancer with immunotoxicity
Element) and the cellular immunity reaction of decline, especially ether extract can activate or strengthen cellular immunity, and NK
Activity, to improve immunity have the effect of very big.
(5) diabetes are controlled：Korean red ginseng contains the material for promoting insulin secretion and similar insulin action, wherein people
Ginseng saponin(e can improve hyperglycaemia, efficiently control the generation of diabetes.
(6) it is good for liver：There is antihepatitic activity in Korean ginseng composition, there is removing toxic substances, protect liver and promote liver regeneration, recover
Effect.Relieve the effect of alcohol in addition, Korean red ginseng also has, eliminate the effect being still drank after a night.
(7) blood pressure is adjusted：Korean red ginseng has expansion blood vessel function, can improve blood circulation, saponin constituent therein leads to
Promotion vascular endothelial cell release nitric oxide is crossed, can reach hypotensive activity.
(8) antifatigue and resistance to compression：It has been investigated that locomitivity can be improved and alleviate tired by persistently taking Korean red ginseng
Labor, have very great help to the recovery and prevention exercise induced anemia for promoting player's fatigue accumulation；In addition, Korean red ginseng can also increase
By force to the tolerance of the adverse environments such as low temperature (5 DEG C, O DEG C, -10 DEG C) and high temperature (35 DEG C), by entering to pressure or environmental change
The exquisite regulation of row, improves anti-pressure ability, maintains organism stability.
(9) Menopause obstacle is improved：According to investigations, there is the women of climacteric impairment property after Korean red ginseng is taken,
There is 80% people to recognize that symptom is obviously improved after taking Korean red ginseng.Expert claims, and these women such as adjust dosage according to symptom,
Curative effect can also be improved.
(10) male sexual disfunction is improved：Korean red ginseng can prevent the male sexual disfunction caused by pressure.Through facing
Bed experiment, after erectile dysfunction patient (90 people) takes Korean red ginseng, has all changed in the degree of erection, sexual desire and satisfaction etc.
It is kind.
(11) anti-oxidant and anti-aging：Korean red ginseng has the antioxygen increased with lipid peroxidation for suppressing harmful active oxygen
Change effect.
2 pen shell shellfish pen shell shellfishes also make " river ray ", " Jiang Yao ".A kind of extra large freshwater mussel.Shell is slightly triangular in shape, the grey black in surface.Life
In the silt of seashore.Cedductor delicious, it is seafood delights treasure.Jiang Yaobei is not only delicious in taste, and nutritious, except containing abundant
Animal protein, outside calcium phosphate and vitamin, cow-bezoar acid content is also especially high, and contained taurine is combined into ox sulphur courage with cholic acid
Acid, participate in digesting and assimilating for lipid.In addition, Jiang Yaobei posts also have the effect of kidney tonifying, relieving the five internal organs, treatment is quenched one's thirst, and place is eaten in the abdomen that can disappear.
3 seaweed seaweeds are Bangiales section seaweed Porphyra haitanensis thalluses.
(1) laver nutritive enriches, and amount of iodine is very high, and available for treatment " Thyroid Gland Swell " caused by iodine deficiency, seaweed has
Softening and resolving hard mass function, also there is purposes to other pent-ups product block；
(2) seaweed rich in choline and calcium, iron, can strengthen memory, treat woman anemia, promotion bone, tooth growth and
Health care；, can be as the accesary foods for the treatment of oedema containing a certain amount of mannitol；
(3) polysaccharide contained by seaweed, which has, is remarkably reinforced cellular immunity and humoral immune function, and lymphocyte can be promoted to turn
Change, improve the immunity of body；The total content into serum cholesterol can be significantly reduced；
(4) active ingredient of seaweed is to the inhibiting rate 53.2% of ehrlich carcinoma, contribute to brain tumor, breast cancer, thyroid cancer,
The preventing and treating of the tumours such as malignant lymphoma.
(5) taurine contained by seaweed is combined into taurocholate with cholic acid, participates in digesting and assimilating for lipid.
4 extra large Yun Hai accumulate the frond accumulate for Hai Yun sections plant sea.
Contain the composition " pheophytin " (Fucoidan, also known as rock algae polysaccharide/brown alga polysaccharide/fucoidin) for having uniqueness in sea.″
Pheophytin " be it is a kind of it is natural it is anti-oxidant, decompose free radical and strengthen the material of immunocompetence, various researchs are pointed out, in cancer
During treatment, pheophytin can bring a variety of protection mechanisms to body：
" pheophytin " outstanding part is that it, just for bad cell, promotes bad cell but to have to normal cell from death of going out
Protective effect." pheophytin " is also one kind of dietary fiber, therefore can mix cholesterol unnecessary in enteron aisle and harmful substance, so
After excrete.The state of mind can be effectively facilitated by taking " pheophytin ", so that appetite enhancing, muscle power increase, had preferably
Sleep, to have more preferable constitution and the state of mind to anticancer.
5 jujubes also known as jujube, dry jujube, Chinese date, originating from China, has the plantation history of more than 8,000 years in China, from ancient times
Since be just listed in one of " five fruits " (chestnut, peach, Lee, apricot, jujube).Jujube is rich in protein, fat, carbohydrate, carrotene, B races dimension
The nutritional ingredient such as raw element, vitamin C, citrin and calcium, phosphorus, iron and CAMP.Wherein ascorbic content is in fruit
Come out at the top in product, there is the laudatory title of vitamin king.According to a clinical studies show of foreign countries：The continuous patient for eating jujube, health
Recover than eating fast more than 3 times of vitamin medicament merely.CAMP contained by jujube be human body cell energetic supersession must
Composition is needed, muscular strength, dispelling fatigue, expansion blood vessel, increase myocardial contractive power, improvement myocardial nutrition can be strengthened, to preventing and treating painstaking effort
Guard system disease plays the role of good；Chinese medicine theory thinks that jujube is to chronic hepatitis, hepatic sclerosis, anaemia, anaphylactoid purpura
There is good therapeutic effect etc. illness；Jujube contains triterpene compound and CAMP, there is stronger anticancer, anti-allergic effects.
The content of the invention：
1st, a kind of algin is the preparation method of the norcholesterol soft capsule preparation of capsule material, and its feature is as follows：
(1) capsule material supplementary material composition and weight are agar 1.0-3.0kg, trigonella bean gum 0.3-1.0kg, sodium alginate 0.2-
0.4kg, bourbonal,ethyl vanillin 0.01-0.02kg, titanium dioxide 0.02-0.03kg, glycerine 0.1-0.2kg, sorbierite or xylose
Alcohol 0.1-0.2kg；
(2) capsule core material supplementary material weight be Korean red ginseng 60-90g, pen shell shellfish 200-500g, seaweed 60-90g, sea accumulate 60-
90g, jujube 30-60g；
(3) Korean red ginseng in (2) being carried out into water to extract 3-4 times, each amount of water is 6-8 times of Korean red ginseng weight,
Time is each 3-4h, 60-80 DEG C, obtains aqueous extract, is merged, and 60-80 DEG C to be concentrated under reduced pressure into every milliliter of aqueous extract suitable
In the amount containing 1g Korean red ginsengs, as Korean red ginseng medicinal extract；
(4) by Korean red ginseng medicinal extract in (3), glucose 120-180g, lactic acid bacteria 3-9g are added, ferment 72- at 39-43 DEG C
96h, lactobacillus-fermented Korean red ginseng extract is obtained, 60-80 DEG C is concentrated under reduced pressure, dries, and mixes；
(5) by vacuum freezedrying after the pen shell shellfish removing impurity in (2), then colloid mill or vibromill or airflow milling are passed through
Micron powder is crushed into, is mixed；
(6) seaweed in (2), sea are accumulate and carries out water with jujube and extract 3-4 time, each amount of water is that seaweed, sea accumulate and greatly
6-8 times of jujube gross weight, time are each 3-4h, 60-80 DEG C, obtain seaweed, sea accumulate with jujube aqueous extract, merge, 60-80 DEG C
It is concentrated under reduced pressure, dries, mix, as seaweed, the extra large water extract accumulate with jujube；
(7) by seaweed in pen shell shellfish micron powder in lactobacillus-fermented Korean red ginseng extract in (4) and (5) and (6),
Sea accumulates to be mixed with the water extract of jujube, as capsule core material；
(8) capsule material supplementary material in (1) is put into 7.0-8.5kg deionized water, keeps entering for 30 minutes at 85-90 DEG C
Row colloidal sol；Deaerated under 85-90 DEG C of 0.5 vacuum 10-12 minutes, turn into capsule material glue；
(9) by capsule material glue glue piece in (8), capsule core material in (7) is added, soft capsule preparation is prepared by pressing.
A kind of preparation method it is an object of the invention to provide algin for the norcholesterol soft capsule preparation of capsule material, capsule
Material has the characteristics of strong extensibility, tension force, good toughness；Soft capsule preparation has norcholesterol, improves immunity of organisms and auxiliary
The function of anticancer.
Specific embodiment：
A kind of algin of the present invention includes following reality for the preparation method of the norcholesterol soft capsule preparation of capsule material
Example is applied, the following examples can further illustrate the present invention, but do not limit the invention in any way.
Embodiment 1：
1st, a kind of algin is the preparation method of the norcholesterol soft capsule preparation of capsule material, and its feature is as follows：
(1) capsule material supplementary material composition and weight be agar 1.0kg, trigonella bean gum 0.3kg, sodium alginate 0.2kg, ethyl it is fragrant
Blue aldehyde 0.01kg, titanium dioxide 0.02kg, glycerine 0.1kg, sorbierite or xylitol 0.1kg；
(2) capsule core material supplementary material weight be Korean red ginseng 60g, pen shell shellfish 200g, seaweed 60g, sea accumulate 60g, jujube 30g；
(3) Korean red ginseng in (2) is carried out into water to extract 3 times, each amount of water is 6 times of Korean red ginseng weight, the time
For each 3h, 60 DEG C, aqueous extract is obtained, is merged, 60 DEG C are concentrated under reduced pressure into every milliliter of aqueous extract equivalent to containing 1g Koryos
The amount of red ginseng, as Korean red ginseng medicinal extract；
(4) by Korean red ginseng medicinal extract in (3), glucose 120g, lactic acid bacteria 3g are added, ferment 96h at 39 DEG C, obtains lactic acid
Bacterium fermentation Korean red ginseng extract, 60 DEG C are concentrated under reduced pressure, dry, and mix；
(5) by vacuum freezedrying after the pen shell shellfish removing impurity in (2), then colloid mill or vibromill or airflow milling are passed through
Micron powder is crushed into, is mixed；
(6) seaweed in (2), sea are accumulate and carries out water extraction 3 times with jujube, each amount of water is seaweed, sea accumulates and jujube
6 times of gross weight, time are each 3h, 60 DEG C, obtain seaweed, sea accumulate with jujube aqueous extract, merge, 60 DEG C are concentrated under reduced pressure, do
It is dry, mix, as seaweed, the extra large water extract accumulate with jujube；
(7) by seaweed in pen shell shellfish micron powder in lactobacillus-fermented Korean red ginseng extract in (4) and (5) and (6),
Sea accumulates to be mixed with the water extract of jujube, as capsule core material；
(8) capsule material supplementary material in (1) is put into 7.0kg deionized water, keeps carrying out colloidal sol in 30 minutes at 85 DEG C；
Deaerated 10 minutes under 85 DEG C of 0.5 vacuums, turn into capsule material glue；
(9) by capsule material glue glue piece in (8), capsule core material in (7) is added, soft capsule preparation is prepared by pressing.
Embodiment 2：
1st, a kind of algin is the preparation method of the norcholesterol soft capsule preparation of capsule material, and its feature is as follows：
(1) capsule material supplementary material composition and weight be agar 3.0kg, trigonella bean gum 1.0kg, sodium alginate 0.4kg, ethyl it is fragrant
Blue aldehyde 0.02kg, titanium dioxide 0.03kg, glycerine 0.2kg, sorbierite or xylitol 0.2kg；
(2) capsule core material supplementary material weight be Korean red ginseng 90g, pen shell shellfish 500g, seaweed 90g, sea accumulate 90g, jujube 60g；
(3) Korean red ginseng in (2) is carried out into water to extract 4 times, each amount of water is 8 times of Korean red ginseng weight, the time
For each 4h, 80 DEG C, aqueous extract is obtained, is merged, 80 DEG C are concentrated under reduced pressure into every milliliter of aqueous extract equivalent to containing 1g Koryos
The amount of red ginseng, as Korean red ginseng medicinal extract；
(4) by Korean red ginseng medicinal extract in (3), glucose 180g, lactic acid bacteria 9g are added, ferment 72h at 43 DEG C, obtains lactic acid
Bacterium fermentation Korean red ginseng extract, 80 DEG C are concentrated under reduced pressure, dry, and mix；
(5) by vacuum freezedrying after the pen shell shellfish removing impurity in (2), then colloid mill or vibromill or airflow milling are passed through
Micron powder is crushed into, is mixed；
(6) seaweed in (2), sea are accumulate and carries out water extraction 4 times with jujube, each amount of water is seaweed, sea accumulates and jujube
8 times of gross weight, time are each 4h, 80 DEG C, obtain seaweed, sea accumulate with jujube aqueous extract, merge, 80 DEG C are concentrated under reduced pressure, do
It is dry, mix, as seaweed, the extra large water extract accumulate with jujube；
(7) by seaweed in pen shell shellfish micron powder in lactobacillus-fermented Korean red ginseng extract in (4) and (5) and (6),
Sea accumulates to be mixed with the water extract of jujube, as capsule core material；
(8) capsule material supplementary material in (1) is put into 8.5kg deionized water, keeps carrying out colloidal sol in 30 minutes at 90 DEG C；
Deaerated 12 minutes under 90 DEG C of 0.5 vacuums, turn into capsule material glue；
(9) by capsule material glue glue piece in (8), capsule core material in (7) is added, soft capsule preparation is prepared by pressing.
Claims (1)
1. a kind of algin is the preparation method of the norcholesterol soft capsule preparation of capsule material, its feature is as follows：
(1) capsule material supplementary material composition and weight are agar 1.0-3.0kg, trigonella bean gum 0.3-1.0kg, sodium alginate 0.2-
0.4kg, bourbonal,ethyl vanillin 0.01-0.02kg, titanium dioxide 0.02-0.03kg, glycerine 0.1-0.2kg, sorbierite or xylose
Alcohol 0.1-0.2kg；
(2) capsule core material supplementary material weight be Korean red ginseng 60-90g, pen shell shellfish 200-500g, seaweed 60-90g, sea accumulate 60-90g,
Jujube 30-60g；
(3) Korean red ginseng in (2) is carried out into water to extract 3-4 times, each amount of water is 6-8 times of Korean red ginseng weight, the time
For each 3-4h, 60-80 DEG C, obtain aqueous extract, merge, 60-80 DEG C be concentrated under reduced pressure into every milliliter of aqueous extract equivalent to containing
There are the amount of 1g Korean red ginsengs, as Korean red ginseng medicinal extract；
(4) by Korean red ginseng medicinal extract in (3), glucose 120-180g, lactic acid bacteria 3-9g are added, ferment 72-96h at 39-43 DEG C,
Lactobacillus-fermented Korean red ginseng extract is obtained, 60-80 DEG C is concentrated under reduced pressure, dries, and mixes；
(5) the pen shell shellfish in (2) is removed into vacuum freezedrying after impurity, then by colloid mill or vibromill or airflow milling by its
Crush as micron powder, mixing；
(6) seaweed in (2), sea are accumulate and carries out water with jujube and extract 3-4 time, it is total with jujube that each amount of water is that seaweed, sea accumulate
6-8 times of weight, time are each 3-4h, 60-80 DEG C, obtain seaweed, sea accumulates and jujube aqueous extract, merging, 60-80 DEG C of decompression
Concentration, dry, mix, as seaweed, the extra large water extract accumulate with jujube；
(7) by seaweed, Hai Yun in pen shell shellfish micron powder in lactobacillus-fermented Korean red ginseng extract in (4) and (5) and (6)
Mixed with the water extract of jujube, as capsule core material；
(8) capsule material supplementary material in (1) is put into 7.0-8.5kg deionized water, keeps progress in 30 minutes molten at 85-90 DEG C
Glue；Deaerated under 85-90 DEG C of 0.5 vacuum 10-12 minutes, turn into capsule material glue；
(9) by capsule material glue glue piece in (8), capsule core material in (7) is added, soft capsule preparation is prepared by pressing.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2021055365A1 (en) * | 2019-09-16 | 2021-03-25 | Cargill, Incorporated | Seaweed-based composition |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104338142A (en) * | 2013-07-31 | 2015-02-11 | 山东大学（威海） | Dropping pill with algal polysaccharide and flaxseed gum as capsule wall material, and its production technology |
| CN104337779A (en) * | 2013-07-31 | 2015-02-11 | 山东大学（威海） | Dropping pill with seaweed gel and agar as capsule wall material, and its production technology |
| CN105495414A (en) * | 2016-01-04 | 2016-04-20 | 环翠楼红参生物科技股份有限公司 | Preparation method for radix ginseng rubra-sesame anti-aging functional food |
| CN105533415A (en) * | 2016-01-04 | 2016-05-04 | 环翠楼红参生物科技股份有限公司 | Method for preparing Korean red ginseng and wheat germ antioxidant food |
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2017
- 2017-10-18 CN CN201710970047.4A patent/CN107712894A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104338142A (en) * | 2013-07-31 | 2015-02-11 | 山东大学（威海） | Dropping pill with algal polysaccharide and flaxseed gum as capsule wall material, and its production technology |
| CN104337779A (en) * | 2013-07-31 | 2015-02-11 | 山东大学（威海） | Dropping pill with seaweed gel and agar as capsule wall material, and its production technology |
| CN105495414A (en) * | 2016-01-04 | 2016-04-20 | 环翠楼红参生物科技股份有限公司 | Preparation method for radix ginseng rubra-sesame anti-aging functional food |
| CN105533415A (en) * | 2016-01-04 | 2016-05-04 | 环翠楼红参生物科技股份有限公司 | Method for preparing Korean red ginseng and wheat germ antioxidant food |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2021055365A1 (en) * | 2019-09-16 | 2021-03-25 | Cargill, Incorporated | Seaweed-based composition |
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