CN107440124A - A kind of algin is the preparation method of the blood fat reducing soft capsule preparation of capsule material - Google Patents
A kind of algin is the preparation method of the blood fat reducing soft capsule preparation of capsule material Download PDFInfo
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- CN107440124A CN107440124A CN201710944606.4A CN201710944606A CN107440124A CN 107440124 A CN107440124 A CN 107440124A CN 201710944606 A CN201710944606 A CN 201710944606A CN 107440124 A CN107440124 A CN 107440124A
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- capsule
- extract
- red ginseng
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- korean red
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- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L17/00—Food-from-the-sea products; Fish products; Fish meal; Fish-egg substitutes; Preparation or treatment thereof
- A23L17/60—Edible seaweed
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L19/00—Products from fruits or vegetables; Preparation or treatment thereof
- A23L19/01—Instant products; Powders; Flakes; Granules
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
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Abstract
Health food belonging to the present invention researchs and develops technical field.A kind of preparation method the present invention relates to algin for the blood fat reducing soft capsule preparation of capsule material.Capsule material supplementary material composition is agar, methylcellulose, sodium alginate, bourbonal,ethyl vanillin, titanium dioxide, glycerine, sorbierite or xylitol；Lactobacillus-fermented Korean red ginseng extract and hawthorn micron powder and kelp, the water extract of agaric and jujube are mixed, as capsule core material；Capsule material supplementary material is put into deionized water, keeps carrying out colloidal sol in 30 minutes；Deaerated 10 12 minutes under 0.5 vacuum, turn into capsule material glue；By capsule material glue glue piece, capsule core material is added, soft capsule preparation is prepared by pressing.Product capsule material of the present invention has the characteristics of strong extensibility, tension force, good toughness；Soft capsule preparation has reducing blood lipid, improves the function of immunity of organisms, anti-aging and anticancer adjuvant.
Description
Technical field：
Health food belonging to the present invention researchs and develops technical field.The present invention relates to the reducing blood lipid that a kind of algin is capsule material
The preparation method of soft capsule preparation.Product capsule material of the present invention has the characteristics of strong extensibility, tension force, good toughness；Soft capsule preparation
Function with reducing blood lipid, raising immunity of organisms, anti-aging and anticancer adjuvant.
Background technology：
Soft capsule (Soft Capsule) has turned into current clinical practice most widely medicinal system since nineteen thirty-five comes out
One of agent.Many oilies, liquid even paste raw materials medicine can be processed into soft capsule.All kinds of flexible glues that countries in the world have listed
Capsule preparation is up to hundreds of, including VE soft capsules, oenothera biennis soft capsule, polyenoid caring soft capsule, deep-sea fish oil soft capsules etc.
Conventional kind and panoramic health-care preparation soft capsule (such as cod-liver oil soft capsule, sabal fat capsule).It is soft
Capsule is primary raw material using pharmagel as hard shell capsules.Gelatin after animal slaughtering byproduct (mainly pig,
Ox, sheep bone and pigskin and ox-hide).But Britain is bright so as to feed through to there occurs world-shaking rabid ox disease event since the nineties
Glue market.Because European's eating beef, therefore ox bone and ox-hide are the primary raw materials of European Gelatin Industry.Because the public is to crazy ox
With panic, some environmental protection organizations (such as green peace organization) start to resist the gelatin from ox byproduct the generally worry of disease.With
This simultaneously, the national requirements import gelatin being a Moslem must be (can not being carried doped with pigskin and pig bone for " Islamic "
The gelatin taken).But for manufacturing of gelatin factory, one is deposited in because the Animal Bone purchased from various regions mixes mostly
Rise, it is difficult to thoroughly separate, therefore require that the raw material of production gelatin definitely meets " Islamic " requirement and I'm afraid that operation difficulty is larger.This
In the case of, some Islam also resist the import of soft-gelatin capsule preparation.This just makes to traditional soft capsule preparation industry
Into great impact.Find the gelatin substitute products of non-animal turns into the task of top priority as soft capsule auxiliary material.Additionally due to
Gelatin belongs to protein matter, and hygroscopicity is strong, and the medicine moisture absorption can be made to go bad, led the water transport of absorption to internal drug
Cause the off quality and term of validity short.
Agar, scientific name agar-agar, English name (agar), also known as agar (agar-agar), agar-agar, agar-agar, are natural plant gum
One kind, the Eucheumas of conventional marine products, agar, fragrant plant mentioned in ancient texts etc. is made, and is solid colourless, without solid shape, is dissolved in hot water.Eating
It is widely used in product industry, is also commonly used for bacteria culture media.
Agar is the polysaccharide body by being extracted in marine alga, is current one of widest algin of purposes in the world.It is eating
Many aspects such as product industry, medical industry, daily-use chemical industry, bioengineering have a wide range of applications, and agar is used for can be bright in food
The aobvious quality for changing food, improve the class of food.Price is very high.Its feature：With coagulability, stability can be with some things
Matter forms the physicochemical properties such as complex compound, can be used as thickener, coagulator, suspending agent, emulsifying agent, antistaling agent and stabilizer.
It is widely used in manufacture orange granule juice and various beverages, jelly, ice cream, cake, soft sweets, can, meat products, mixed congee, white fungus swallow
Nest, custard based food, stir-fried food etc. agar medical research, can make culture medium, ointment base and other purposes in chemical industry.
The agar made of algae is translucent, unbodied powder, thin slice or particle.Processing is mainly distributed on mountain
There is processing east, Liaoning, Guangdong each province.Agar profile has several not homomorphs such as slice, strip, thin slice, fritter, with thin
Bar is preferred.The external place of production is Japan, Korea, New Zealand, the U.S. and Russia.Agar does not dissolve in cold water, can absorb quite in itself
The water that 20 times of volume.Boiling water is soluble in, dilution still keeps liquid at 42 DEG C (108 °F), but congeals into close jelly at 37 DEG C.
Agar is the constituent of cell membrane, contains complicated carbohydrate, calcium and sulfate.
The most useful characteristic of agar is that the temperature difference between its condensation point and fusing point is very big.It needs to be heated to 95 in water
DEG C when just start to melt, just start to solidify when the solution temperature after fusing need to drop to 40 DEG C, thus it be prepare solid medium
Best coagulator.The solid medium prepared with agar, is used for high-temperature cultivation and non-fusible, is inoculated with before curing
When, culture will not also be scalded dead.Therefore, agar is to prepare most widely used a kind of coagulator in various biological mediums.
The 1~1.5% of the concentration of agar, typically fluid nutrient medium.
Methylcellulose methylcellulose for white or off-white color threadiness or particulate powder, it is odorless, it is tasteless.This product exists
Clarification or slightly cloudy colloidal solution are swelled into water；It is insoluble in absolute ethyl alcohol, chloroform or ether.Methylcellulose is white
Or off-white color threadiness or particulate powder, it is odorless.Mean molecule quantity 186.86n (n is the degree of polymerization), about 18000~200000.
Character：Methylcellulose is almost insoluble in absolute ethyl alcohol, ether, acetone.In 80~90 ＞；DEG C hot water in rapidly disperse,
Swelling, dissolves rapidly after cooling, aqueous solution quite stable at normal temperatures, during high temperature can gel, and this gel can be with temperature
Height and the mutual phase in version of solution.With excellent wetability, dispersiveness, cementability, thickening property, emulsibility, water-retaining property and film forming
Property, and the impermeability to grease.Institute's film forming has excellent toughness, flexibility and transparency, can be with it because belonging to nonionic
His emulsifying agent compatibility, but easily saltout, solution is stable in the range of PH2-12.Thickener as Water-soluble adhesive, such as chlorine
The thickener of fourth latex.It also is used as vinyl chloride, dispersant, emulsifying agent and stabilizer that styrene suspension polymerize etc..
Sodium alginate is a kind of polysaccharide carbohydrate extracted from the sea-tangle or sargassum of brown algae, is by by d-L-
Mannuronic acid (M units) is with β-D- guluronic acids (G units) by Isosorbide-5-Nitrae-glucosides key connection and by GM, MM of different proportion
It is one kind in alginic acid derivative, so sometimes referred to as sodium alginate or seaweed gel and sea with the copolymer of GG fragments composition
Phycocolloid.Sodium alginate is widely used in chemistry, biology, medicine, food with its good biological degradability and biocompatibility
The fields such as product.
With understanding of the people to plant capsule, and the transformation of public's medication theory both at home and abroad, it will make plant origin
The market demand of capsule increases rapidly.Simultaneously because plant capsule can trust without using any gelatin, numerous Moslems patient
Powder charge is taken, and product can export to vast Islam and kosher area, will be earned foreign exchange for country, and improve enterprise
Economic benefit.
1 Korean red ginseng is process by the fresh ginseng in the Koryo for originating from South Korea through steaming, toasting, in processing Korean red ginseng process
In, there is new anticancer active constituent to produce.Korean red ginseng is not not cool also warm, belongs to warm nature；Though Korean ginseng is warm-natured but benefit property is strong, benefit
Gas helps fire.Korean ginseng divides white ginseng and red ginseng again, and insufficiency of the spleen hyperactivity of fire person preferably uses white ginseng, because of " life gas is cool, slight bitter tonifying yin "；Insufficiency of the spleen lung is timid
Person preferably uses red ginseng, " ripe to use temperature, sweet yang-tonifying ".On the whole, Korean ginseng is more suitable for the frank people of the old deficiency of vital energy and taken,
The strong constitution of energy, strengthen immunity.
The effect of Korean red ginseng：
(1) brain healthy：The people that declines to failure of memory and sports coordination ability and it is on the drink or contact with second
The food of alcohol composition, the people of medicine, Korean red ginseng, which has to improve mental working ability, enhancing memory and improve cerebral ischemia, to be hindered
The effect of hindering
(2) ease pain：Some experts by do sensory nerve cell experiment find, Korean ginseng to the various pain symptoms of body all
It is helpful.
(3) anti-cancer and anticancer：The saponin constituent of Korean red ginseng and non-saponin constituent have the propagation for suppressing a variety of cancer cells to live
Property, while can also suppress cancer metastasis.In addition, Korean red ginseng is taken together with anticancer, anticancer effect is better than individually with anti-
Cancer agent (mitomycin).Because cancer cell easily forms tolerance in chemotherapy of tumors, Korean red ginseng, with taking, strengthens with anticancer
The side effect of lethality, mitigation anticancer to cancer cell.
(4) strengthen immunity：Korean red ginseng extract can recover that (mitogen is mould because taking the anticancer with immunotoxicity
Element) and the cellular immunity reaction of decline, especially ether extract can activate or strengthen cellular immunity, and NK
Activity, to improve immunity have the effect of very big.
(5) diabetes are controlled：Korean red ginseng contains the material for promoting insulin secretion and similar insulin action, wherein people
Ginseng saponin(e can improve hyperglycaemia, efficiently control the generation of diabetes.
(6) it is good for liver：There is antihepatitic activity in Korean ginseng composition, there is removing toxic substances, protect liver and promote liver regeneration, recover
Effect.Relieve the effect of alcohol in addition, Korean red ginseng also has, eliminate the effect being still drank after a night.
(7) blood pressure is adjusted：Korean red ginseng has expansion blood vessel function, can improve blood circulation, saponin constituent therein leads to
Promotion vascular endothelial cell release nitric oxide is crossed, can reach hypotensive activity.
(8) antifatigue and resistance to compression：It has been investigated that locomitivity can be improved and alleviate tired by persistently taking Korean red ginseng
Labor, have very great help to the recovery and prevention exercise induced anemia for promoting player's fatigue accumulation；In addition, Korean red ginseng can also increase
By force to the tolerance of the adverse environments such as low temperature (5 DEG C, O DEG C, -10 DEG C) and high temperature (35 DEG C), by entering to pressure or environmental change
The exquisite regulation of row, improves anti-pressure ability, maintains organism stability.
(9) Menopause obstacle is improved：According to investigations, there is the women of climacteric impairment property after Korean red ginseng is taken,
There is 80% people to recognize that symptom is obviously improved after taking Korean red ginseng.Expert claims, and these women such as adjust dosage according to symptom,
Curative effect can also be improved.
(10) male sexual disfunction is improved：Korean red ginseng can prevent the male sexual disfunction caused by pressure.Through facing
Bed experiment, after erectile dysfunction patient (90 people) takes Korean red ginseng, has all changed in the degree of erection, sexual desire and satisfaction etc.
It is kind.
(11) anti-oxidant and anti-aging：Korean red ginseng has the antioxygen increased with lipid peroxidation for suppressing harmful active oxygen
Change effect.
(12) reinforce vital energy.
2 kelp kelps (Ecklonia Kurome Okem), kelp is a category of Phaeophyta-Laminariales-Alariaceae, is
The water warm algae of North Western Pacific.It is mainly distributed on China East Sea Fujian Province Pingtan, the band of Putian one, island in Zhejiang Province Yu Shan
Also it is distributed.
(1) to thyroid effect：Tool acts on the iodine contained by being due to, caused by iodide.Kelp can be used to correct by
Thyroid function deficiency caused by iodine deficiency, while can also temporarily suppress the metabolic rate of hyperthyroidism and mitigate
Symptom, but can not be lasting, the preparation before can operating.After iodide enter tissue and blood, it can still promote pathological product such as inflammation
The absorption of disease exudate, and the tissue collapse and dissolving of morbid state can be made, therefore active tuberculosis is not had to typically.It is contained in kelp
Iodine, more simple iodine, KI absorb slow, internal retention time length, and discharge is also slow.
(2) antihypertensive effect：Laminine (Laminine) has antihypertensive effect, and laminine list citrate is to anesthetized rabbit
Intravenous injection, can make the of short duration decline of blood pressure, and this effect is not by That atropine blocks；It does not influence inaccessible two side arteria carotis communis or injection
The booster reaction that norepinephrine causes；In body and isolated test, it can suppress heartbeat amplitude, but not influence heartbeat frequency
Rate.There are more significant inhibitory action, such as small intestine, bronchus to smooth muscle.And can be to anti-acetylcholine, serotonin, chlorination
The contraction that barium causes；On Isolated Rat small intestine, the effect to anti-acetylcholine is the 0.8% of papaverine.In isolated guinea pig semen deposition
Guan Shangneng strengthens the effect of norepinephrine.Effect to frog rectus aabdominis is very weak.Laminine mono-hydrochloric salts can be also depressured simultaneously
Suppress isolated rabbit intestines；But there is slight excitation to extrasomatic rabbit heart.
(3) hypoglycemic effect：Contained laminaran 30ml/kg gavages have obvious hypoglycemic work to normal mouse in kelp
With when dosage reaches 100mg/kg, blood glucose reduces by 49% after 7 hours.The hypoglycemic effect of sodium alginate is poor, and gavage is invalid,
100mg/kg intraperitoneal injections just have obvious hypoglycemic fruit effect, and when dosage reaches 300m/kg, blood glucose can reduce by 38% within 7 hours.To four
Nitrogen pyrimidine hyperglycaemia, laminaran 300mg/kg gavages, blood glucose reduces by 61% after 24 hours；Sodium alginate 300mg/kg abdominal cavities
Injection；Blood glucose reduces by 39%, and gavage is invalid.Marine alga bar is shown in other effects.
(4) reducing blood lipid and anticoagulation：The multiple gavage of laminarin, it can significantly suppress the total courage of high fat of blood chicken serum and consolidate
Alcohol, the content of triglycerides rise, and can reduce the formation and development of chicken aortic tunica intima atheromatous plaque.Laminarin is in vivo
There is blood coagulation resisting function outside, its anticoagulating active is 7 heparin u/mg.Because many patients with coronary heart disease are in addition to having high fat of blood, its blood is normal
In hypercoagulative state.Therefore, laminarin has reducing blood lipid and anticoagulation simultaneously, and clinic is had the certain significance.
(5) anti-radiation acts on：The injection of laminarin 1 time, can significantly improve 900 rads irradiation mouse survival rate, and with
Dosage increase survival rate improves, and can significantly protect the hematopoietic tissue of irradiation animal.Therefore, laminarin is put for prevention
Hematopoietic tissue caused by treatment is damaged, and is stimulated Radiation in jury and is strengthened the immunologic function of cancer patient, one may be had by merging radiotherapy
Determine practical significance.
3 agaric agarics, it is the edible mushroom of Auricularia.The effect of agaric and effect：
(1) agaric that fills blood is described as ' meat or fish in element ' and ' king in element ' by nutritionist, contains in every 100 grams of black fungus
185 milligrams of iron, it is higher by 20 times than iron-holder highest spinach in green vegetable, than iron-holder highest pig in animal food
Liver is also higher by about 7 times, is that the most blood-nourishings of iron-holder are preserved youthful looks in various meat and vegetable foods, and it is ruddy to make us skin, radiant, and can prevent
Control hypoferric anemia；Reduce platelet plug, the generation of pre- preventing thrombosis, the generation of prevention of arterial atherosis and coronary heart disease.
(2) fat-reducing anti-cancer, which treats constipation, can promote gastrointestinal peristalsis, promote the excretion of intestinal fat food, reduce in food
The absorption of fat, so as to prevent obesity；Simultaneously as both materials can promote gastrointestinal peristalsis, constipation is prevented, is advantageous in vivo
The timely removing and discharge of noxious material in stool, so as to play a part of preventing the carcinoma of the rectum and other cancer in digestive system.Institute
So that the elderly is particularly the elderly for having constipation to be accustomed to, and adheres to edible black fungus, often eats agaric congee, to preventing a variety of old diseases
Disease, anticancer, anti-cancer, anti-aging have good effect.
(3) dust that remains in digestion, impurity absorption can be put together discharge body by gut purge stomach agaric
Outside, intestines are washed so as to play a part of clearing stomach, it also has more significant neutralizing work(to endogenous foreign matters such as gall stone, kidney stones
Energy.
4 hawthorn hawthorn also cry large-fruited Chinese hawthorn, are the dry mature fruit of rosaceous plant large-fruited Chinese hawthorn or hawthorn.Hawthorn has very
High nutritive value and medical value, the elderly often eat haw products and can whetted the appetite, and improve sleep, keep in bone and blood
Constant, the prevention of arterial atherosis of calcium, therefore hawthorn is considered as " life prolonging food ".
(1) antihypertensive effect：Hawthorn has expansion peripheral vascular and has lasting antihypertensive effect, the especially drop to cold-blooded animal
Press acting duration most long, when hawthorn and certainly black soup share, its antihypertensive effect greatly enhances, and action time is also
Extend.
(2) resist myocardial ischemia：Hawthorn fruit total flavone can mitigate the ST sections change of Myocardial Ischemia-reperfusion Injury electrocardiogram, improve
The concentration of serum NO level, the level of cardiac muscular tissue's MDA (MDA) when reducing myocardial ischemia-reperfusion.Hawthorn polymerization flavones can reduce
Rabbit experimental myocardial infarction scope.Document report, haw thorn extract can suppress in ischemia-reperfusion rat blood serum the liter of (LDH)
Height, SOD vigor is improved, reduce MDA growing amount, so as to protect cardiac muscle, cardiac muscle cell damages caused by mitigating ischemia-reperfusion
Wound.
(3) Lipid-regulating effect：Hawthorn fruit total flavone shows significant Lipid-regulating effect, to rat aorta caused by hyperlipidemia
Function damage has obvious protective function, and Chen Zhiqian coordinates certainly black soup treatment dyslipidemia patient 65 to show, treated with hawthorn
TC, LDL-C are remarkably decreased afterwards, and before and after treatment relatively, difference has the meaning of highly significant, and it is efficient up to 89.2%.
(4) treating cerebral ischemia：Haw thorn leaf total flavone can significantly improve model mice brain tissue LDH and SOD vigor, play a game
The cerebral ischemia re-pouring injured Mice brain tissues of stove have significant protective effect, its mechanism with it is anti-oxidant relevant.
(5) hemorheology is acted on：3 dosage of hawthorn fruit total flavone (80,40,20g/kg) have and reduce stasis syndrome mould
The function of promoting blood circulation to disperse blood clots of type rat whole blood specific viscosity, Plasma Viscosity and packed cell volume.The centering of hawthorn alcohol extracting thing, undercut whole blood
Specific viscosity significantly reduces effect.
(6) to the effect of vascular endothelial cell：The hawthorn of various dose is to caused by the low-density lipoprotein of oxidative modification
Human umbilical vein endothelial cells (EC) are damaged and the direct effect to EC shows that the oxidation that hawthorn can suppress low-density lipoprotein is repaiied
Decorations, reduce the formation of MDA, block the generation of harmful substance, can be by directly acting on endothelial cell, in regulation
Chrotoplast function, strengthen resistance and tolerance of the endothelial cell to injurious factor, so as to protect endothelial cell from infringement.
(7) digestive system acts on：Hawthorn can single application, can also strengthen helping digestion with the compatibility such as Divine Comedy, malt, radish seed
Change the work(of product.It contains vitamin C, vitamin B, carrotene and a variety of organic acids, can orally increase the secretion of digestive ferment in stomach,
Contained protease, aliphatic acid, carnivorous decompose can be promoted to digest.
(8) glycometabolism and antioxidation：Induced by High Fat Diet in Rats fasting blood is can obviously reduce using 6% hawthorn water decoction
Clear insulin and MDA are horizontal, show that it can improve the insulinemia of Induced by High Fat Diet in Rats, enhancing body lipid peroxidation inhibition is made
With its mechanism may be relevant with regulation glycometabolism, and its effective substance may be relevant with Hyperoside and ursolic acid.
Hawthorn tool medicine food dual value, China abound with hawthorn, aboundresources, and economic thing is honest and clean.In recent years, it was in heart and brain blood
Preventive and therapeutic effect in guard system disease turns into the study hotspot of many scholars, is hopeful to be developed into new preventing and treating cardiovascular and cerebrovascular
The medicine of systemic disease.Hawthorn can be not only developed into various health products, also extractable active component, preparation be made and is used to face
Bed, there is wide DEVELOPMENT PROSPECT.
5 jujubes also known as jujube, dry jujube, Chinese date, originating from China, has the plantation history of more than 8,000 years in China, from ancient times
Since be just listed in one of " five fruits " (chestnut, peach, Lee, apricot, jujube).Jujube is rich in protein, fat, carbohydrate, carrotene, B races dimension
The nutritional ingredient such as raw element, vitamin C, citrin and calcium, phosphorus, iron and CAMP.Wherein ascorbic content is in fruit
Come out at the top in product, there is the laudatory title of vitamin king.According to a clinical studies show of foreign countries：The continuous patient for eating jujube, health
Recover than eating fast more than 3 times of vitamin medicament merely.CAMP contained by jujube be human body cell energetic supersession must
Composition is needed, muscular strength, dispelling fatigue, expansion blood vessel, increase myocardial contractive power, improvement myocardial nutrition can be strengthened, to preventing and treating painstaking effort
Guard system disease plays the role of good；Chinese medicine theory thinks that jujube is to chronic hepatitis, hepatic sclerosis, anaemia, anaphylactoid purpura
There is good therapeutic effect etc. illness；Jujube contains triterpene compound and CAMP, there is stronger anticancer, anti-allergic effects.
The content of the invention：
1st, a kind of algin is the preparation method of the blood fat reducing soft capsule preparation of capsule material, and its feature is as follows：
(1) capsule material supplementary material composition and weight are agar 1.0-3.0kg, methylcellulose 0.3-1.0kg, sodium alginate
0.2-0.4kg, bourbonal,ethyl vanillin 0.01-0.02kg, titanium dioxide 0.02-0.03kg, glycerine 0.1-0.2kg, sorbierite or
Xylitol 0.1-0.2kg；
(2) capsule core material supplementary material weight be Korean red ginseng 60-90g, kelp 60-90g, agaric 60-90g, hawthorn 30-60g,
Jujube 30-60g；
(3) Korean red ginseng in (2) being carried out into water to extract 3-4 times, each amount of water is 6-8 times of Korean red ginseng weight,
Time is each 3-4h, 60-80 DEG C, obtains aqueous extract, is merged, and 60-80 DEG C to be concentrated under reduced pressure into every milliliter of aqueous extract suitable
In the amount containing 1g Korean red ginsengs, as Korean red ginseng medicinal extract；
(4) by Korean red ginseng medicinal extract in (3), glucose 120-180g, lactic acid bacteria 3-9g are added, ferment 72- at 39-43 DEG C
96h, lactobacillus-fermented Korean red ginseng extract is obtained, 60-80 DEG C is concentrated under reduced pressure, dries, and mixes；
(5) hawthorn in (2) is crushed into micron powder by colloid mill or vibromill or airflow milling, mixed；
(6) by the kelp in (2), agaric and jujube carry out water extract 3-4 time, each amount of water be kelp, agaric and greatly
6-8 times of jujube gross weight, time are each 3-4h, 60-80 DEG C, obtain kelp, agaric and jujube aqueous extract, are merged, 60-80 DEG C
It is concentrated under reduced pressure, dries, mixes, as the water extract of kelp, agaric and jujube；
(7) by kelp, wood in hawthorn micron powder in lactobacillus-fermented Korean red ginseng extract in (4) and (5) and (6)
The water extract of ear and jujube mixes, as capsule core material；
(8) capsule material supplementary material in (1) is put into 7.0-8.5kg deionized water, keeps entering for 30 minutes at 85-90 DEG C
Row colloidal sol；Deaerated under 85-90 DEG C of 0.5 vacuum 10-12 minutes, turn into capsule material glue；
(9) by capsule material glue glue piece in (8), capsule core material in (7) is added, soft capsule preparation is prepared by pressing.
A kind of preparation method it is an object of the invention to provide algin for the blood fat reducing soft capsule preparation of capsule material, capsule material
With extensibility, the characteristics of tension force is strong, good toughness；Soft capsule preparation have reducing blood lipid, improve immunity of organisms, anti-aging and
The function of anticancer adjuvant.
Specific embodiment：
A kind of algin of the present invention includes following implementation for the preparation method of the blood fat reducing soft capsule preparation of capsule material
Example, the following examples can further illustrate the present invention, but do not limit the invention in any way.
Embodiment 1：
1st, a kind of algin is the preparation method of the blood fat reducing soft capsule preparation of capsule material, and its feature is as follows：
(1) capsule material supplementary material composition and weight are agar 1.0kg, methylcellulose 0.3kg, sodium alginate 0.2kg, ethyl
4-hydroxyl-3-methoxylbenxaldehyde 0.01kg, titanium dioxide 0.02kg, glycerine 0.1kg, sorbierite or xylitol 0.1kg；
(2) capsule core material supplementary material weight is Korean red ginseng 60g, kelp 60g, agaric 60g, hawthorn 30g, jujube 30g；
(3) Korean red ginseng in (2) is carried out into water to extract 3 times, each amount of water is 6 times of Korean red ginseng weight, the time
For each 3h, 60 DEG C, aqueous extract is obtained, is merged, 60 DEG C are concentrated under reduced pressure into every milliliter of aqueous extract equivalent to containing 1g Koryos
The amount of red ginseng, as Korean red ginseng medicinal extract；
(4) by Korean red ginseng medicinal extract in (3), glucose 120g, lactic acid bacteria 3g are added, ferment 96h at 39 DEG C, obtains lactic acid
Bacterium fermentation Korean red ginseng extract, 60 DEG C are concentrated under reduced pressure, dry, and mix；
(5) hawthorn in (2) is crushed into micron powder by colloid mill or vibromill or airflow milling, mixed；
(6) kelp in (2), agaric and jujube are carried out into water to extract 3 times, each amount of water is kelp, agaric and jujube
6 times of gross weight, time are each 3h, 60 DEG C, obtain kelp, agaric and jujube aqueous extract, are merged, 60 DEG C are concentrated under reduced pressure, do
It is dry, mix, as the water extract of kelp, agaric and jujube；
(7) by kelp, wood in hawthorn micron powder in lactobacillus-fermented Korean red ginseng extract in (4) and (5) and (6)
The water extract of ear and jujube mixes, as capsule core material；
(8) capsule material supplementary material in (1) is put into 7.0kg deionized water, keeps carrying out colloidal sol in 30 minutes at 85 DEG C；
Deaerated 10 minutes under 85 DEG C of 0.5 vacuums, turn into capsule material glue；
(9) by capsule material glue glue piece in (8), capsule core material in (7) is added, soft capsule preparation is prepared by pressing.
Embodiment 2：
1st, a kind of algin is the preparation method of the blood fat reducing soft capsule preparation of capsule material, and its feature is as follows：
(1) capsule material supplementary material composition and weight are agar 3.0kg, methylcellulose 1.0kg, sodium alginate 0.4kg, ethyl
4-hydroxyl-3-methoxylbenxaldehyde 0.02kg, titanium dioxide 0.03kg, glycerine 0.2kg, sorbierite or xylitol 0.2kg；
(2) capsule core material supplementary material weight is Korean red ginseng 90g, kelp 90g, agaric 90g, hawthorn 60g, jujube 60g；
(3) Korean red ginseng in (2) is carried out into water to extract 4 times, each amount of water is 8 times of Korean red ginseng weight, the time
For each 4h, 80 DEG C, aqueous extract is obtained, is merged, 80 DEG C are concentrated under reduced pressure into every milliliter of aqueous extract equivalent to containing 1g Koryos
The amount of red ginseng, as Korean red ginseng medicinal extract；
(4) by Korean red ginseng medicinal extract in (3), glucose 180g, lactic acid bacteria 9g are added, ferment 72h at 43 DEG C, obtains lactic acid
Bacterium fermentation Korean red ginseng extract, 80 DEG C are concentrated under reduced pressure, dry, and mix；
(5) hawthorn in (2) is crushed into micron powder by colloid mill or vibromill or airflow milling, mixed；
(6) kelp in (2), agaric and jujube are carried out into water to extract 4 times, each amount of water is kelp, agaric and jujube
8 times of gross weight, time are each 4h, 80 DEG C, obtain kelp, agaric and jujube aqueous extract, are merged, 80 DEG C are concentrated under reduced pressure, do
It is dry, mix, as the water extract of kelp, agaric and jujube；
(7) by kelp, wood in hawthorn micron powder in lactobacillus-fermented Korean red ginseng extract in (4) and (5) and (6)
The water extract of ear and jujube mixes, as capsule core material；
(8) capsule material supplementary material in (1) is put into 8.5kg deionized water, keeps carrying out colloidal sol in 30 minutes at 90 DEG C；
Deaerated 12 minutes under 90 DEG C of 0.5 vacuums, turn into capsule material glue；
(9) by capsule material glue glue piece in (8), capsule core material in (7) is added, soft capsule preparation is prepared by pressing.
Claims (1)
1. a kind of algin is the preparation method of the blood fat reducing soft capsule preparation of capsule material, its feature is as follows：
(1) capsule material supplementary material composition and weight are agar 1.0-3.0kg, methylcellulose 0.3-1.0kg, sodium alginate 0.2-
0.4kg, bourbonal,ethyl vanillin 0.01-0.02kg, titanium dioxide 0.02-0.03kg, glycerine 0.1-0.2kg, sorbierite or xylose
Alcohol 0.1-0.2kg；
(2) capsule core material supplementary material weight is Korean red ginseng 60-90g, kelp 60-90g, agaric 60-90g, hawthorn 30-60g, jujube
30-60g；
(3) Korean red ginseng in (2) is carried out into water to extract 3-4 times, each amount of water is 6-8 times of Korean red ginseng weight, the time
For each 3-4h, 60-80 DEG C, obtain aqueous extract, merge, 60-80 DEG C be concentrated under reduced pressure into every milliliter of aqueous extract equivalent to containing
There are the amount of 1g Korean red ginsengs, as Korean red ginseng medicinal extract；
(4) by Korean red ginseng medicinal extract in (3), glucose 120-180g, lactic acid bacteria 3-9g are added, ferment 72-96h at 39-43 DEG C,
Lactobacillus-fermented Korean red ginseng extract is obtained, 60-80 DEG C is concentrated under reduced pressure, dries, and mixes；
(5) hawthorn in (2) is crushed into micron powder by colloid mill or vibromill or airflow milling, mixed；
(6) kelp in (2), agaric and jujube are carried out into water to extract 3-4 times, each amount of water is that kelp, agaric and jujube are total
6-8 times of weight, the time is each 3-4h, 60-80 DEG C, obtains kelp, agaric and jujube aqueous extract, is merged, 60-80 DEG C of decompression
Concentration, dry, mix, as the water extract of kelp, agaric and jujube；
(7) by kelp in hawthorn micron powder in lactobacillus-fermented Korean red ginseng extract in (4) and (5) and (6), agaric and
The water extract mixing of jujube, as capsule core material；
(8) capsule material supplementary material in (1) is put into 7.0-8.5kg deionized water, keeps progress in 30 minutes molten at 85-90 DEG C
Glue；Deaerated under 85-90 DEG C of 0.5 vacuum 10-12 minutes, turn into capsule material glue；
(9) by capsule material glue glue piece in (8), capsule core material in (7) is added, soft capsule preparation is prepared by pressing.
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| CN105595337A (en) * | 2016-01-08 | 2016-05-25 | 福建农林大学 | Seaweed gel soft capsules assisting in reducing blood glucose and preparation method thereof |
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| CN1552422A (en) * | 2003-12-18 | 2004-12-08 | 华东中药工程集团有限公司 | Motherwort soft capsule and preparing method thereof |
| CN101069678A (en) * | 2007-06-15 | 2007-11-14 | 广东富味制果厂有限公司 | Soft capsule and preparing method thereof |
| CN101810336A (en) * | 2010-04-30 | 2010-08-25 | 广东仙乐制药有限公司 | Chewable soft capsules and method for preparing same |
| CN104337779A (en) * | 2013-07-31 | 2015-02-11 | 山东大学（威海） | Dropping pill with seaweed gel and agar as capsule wall material, and its production technology |
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| CN104770512A (en) * | 2014-01-11 | 2015-07-15 | 山东大学（威海） | Western red ginseng tea preparation method |
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Application publication date: 20171208 |