CN107753961B - Heart color ultrasound coupling agent - Google Patents
Heart color ultrasound coupling agent Download PDFInfo
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- CN107753961B CN107753961B CN201711276162.8A CN201711276162A CN107753961B CN 107753961 B CN107753961 B CN 107753961B CN 201711276162 A CN201711276162 A CN 201711276162A CN 107753961 B CN107753961 B CN 107753961B
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- 238000002604 ultrasonography Methods 0.000 title claims abstract description 26
- 239000007822 coupling agent Substances 0.000 title abstract description 26
- 241001116389 Aloe Species 0.000 claims abstract description 29
- 235000011399 aloe vera Nutrition 0.000 claims abstract description 29
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 28
- 235000011389 fruit/vegetable juice Nutrition 0.000 claims abstract description 25
- 229920002101 Chitin Polymers 0.000 claims abstract description 21
- 239000002994 raw material Substances 0.000 claims abstract description 20
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 19
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims abstract description 17
- 239000002202 Polyethylene glycol Substances 0.000 claims abstract description 17
- 229920002125 Sokalan® Polymers 0.000 claims abstract description 17
- 229960001631 carbomer Drugs 0.000 claims abstract description 17
- 229920001223 polyethylene glycol Polymers 0.000 claims abstract description 17
- -1 alkyl glucoside Chemical class 0.000 claims abstract description 14
- 229930182478 glucoside Natural products 0.000 claims abstract description 14
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 claims abstract description 12
- 229940072056 alginate Drugs 0.000 claims abstract description 12
- 235000010443 alginic acid Nutrition 0.000 claims abstract description 12
- 229920000615 alginic acid Polymers 0.000 claims abstract description 12
- 238000002360 preparation method Methods 0.000 claims abstract description 11
- 238000004140 cleaning Methods 0.000 claims abstract description 5
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 27
- 239000011259 mixed solution Substances 0.000 claims description 20
- 238000002156 mixing Methods 0.000 claims description 18
- 239000000203 mixture Substances 0.000 claims description 13
- 230000001954 sterilising effect Effects 0.000 claims description 8
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 claims description 6
- 235000010413 sodium alginate Nutrition 0.000 claims description 6
- 239000000661 sodium alginate Substances 0.000 claims description 6
- 229940005550 sodium alginate Drugs 0.000 claims description 6
- 238000003756 stirring Methods 0.000 claims description 5
- 239000007864 aqueous solution Substances 0.000 claims description 4
- 238000000034 method Methods 0.000 claims description 4
- 235000010408 potassium alginate Nutrition 0.000 claims description 4
- 239000000737 potassium alginate Substances 0.000 claims description 4
- MZYRDLHIWXQJCQ-YZOKENDUSA-L potassium alginate Chemical compound [K+].[K+].O1[C@@H](C([O-])=O)[C@@H](OC)[C@H](O)[C@H](O)[C@@H]1O[C@@H]1[C@@H](C([O-])=O)O[C@@H](O)[C@@H](O)[C@H]1O MZYRDLHIWXQJCQ-YZOKENDUSA-L 0.000 claims description 4
- 238000001914 filtration Methods 0.000 claims description 2
- 238000000265 homogenisation Methods 0.000 claims description 2
- 238000010298 pulverizing process Methods 0.000 claims description 2
- 239000006228 supernatant Substances 0.000 claims description 2
- 239000000523 sample Substances 0.000 abstract description 12
- 230000000844 anti-bacterial effect Effects 0.000 abstract description 5
- 238000004519 manufacturing process Methods 0.000 abstract description 4
- 230000007797 corrosion Effects 0.000 abstract description 2
- 238000005260 corrosion Methods 0.000 abstract description 2
- 238000001035 drying Methods 0.000 abstract description 2
- 230000000052 comparative effect Effects 0.000 description 7
- 238000004659 sterilization and disinfection Methods 0.000 description 7
- 230000000694 effects Effects 0.000 description 6
- 239000000243 solution Substances 0.000 description 4
- 241000222122 Candida albicans Species 0.000 description 2
- 206010011409 Cross infection Diseases 0.000 description 2
- 241000588724 Escherichia coli Species 0.000 description 2
- 206010029803 Nosocomial infection Diseases 0.000 description 2
- 241000191967 Staphylococcus aureus Species 0.000 description 2
- 239000003899 bactericide agent Substances 0.000 description 2
- 229940095731 candida albicans Drugs 0.000 description 2
- 230000007547 defect Effects 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- 230000002378 acidificating effect Effects 0.000 description 1
- 230000000172 allergic effect Effects 0.000 description 1
- 208000010668 atopic eczema Diseases 0.000 description 1
- 244000052616 bacterial pathogen Species 0.000 description 1
- 239000006227 byproduct Substances 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000003670 easy-to-clean Effects 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 238000012827 research and development Methods 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 238000009736 wetting Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/716—Glucans
- A61K31/722—Chitin, chitosan
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/886—Aloeaceae (Aloe family), e.g. aloe vera
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biotechnology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Alternative & Traditional Medicine (AREA)
- Engineering & Computer Science (AREA)
- Physics & Mathematics (AREA)
- Acoustics & Sound (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Molecular Biology (AREA)
- Cosmetics (AREA)
- Medicines Containing Plant Substances (AREA)
- Detergent Compositions (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention discloses a heart color ultrasound coupling agent which is prepared from the following raw materials in parts by weight: 2-6 parts of aloe juice, 1-3 parts of chitin, 5-7 parts of carbomer, 2.5-3.5 parts of alginate, 2-4 parts of polyethylene glycol, 1.5-2.5 parts of alkyl glucoside, 3-5 parts of ethanol and 100-150 parts of water. The coupling agent provided by the invention has the advantages of rich raw material sources, good antibacterial effect, good wettability and thixotropy, no greasy feeling, easiness in unfolding the coupling agent on the surface of the probe and the skin, difficulty in generating a drying phenomenon after use, no corrosion and damage to the skin and the probe, difficulty in polluting clothes, easiness in cleaning after use, simple preparation method and low production cost.
Description
Technical Field
The invention relates to the technical field of research and development of a coupling agent, and particularly relates to a heart color ultrasound coupling agent.
Background
In the ultrasonic examination process, the impedance difference between the skin and the probe is large, so that the reflection coefficient is large, and in addition, the existence of air between the skin and the probe enables the sound energy of the transmitted sound wave emitted from the probe, which penetrates through an air interface and enters the skin, to be greatly reduced. Therefore, the application in the medical field is wide, for example, two-dimensional color ultrasound, three-dimensional color ultrasound, heart color ultrasound and other examinations often need to use a coupling agent.
The couplant is required to be in contact with a human body when in use, different people can carry some germs when in contact with the couplant, cross infection among inspectors is caused, and operators and users are easy to pollute clothes when using the couplant, which brings difficulty to the cleaning of the clothes. In addition, the existing couplants have more manufacturers, the produced couplants have uneven quality and unequal price. The quality of the coupling agent produced by some manufacturers is poor, stimulation can be caused to the skin of a user, and the allergic phenomena of skin redness and swelling and the like are caused; some coupling agents have unsatisfactory wetting property and strong greasy feeling and are not easy to spread on the skin and the surface of the probe; some coupling agents are acidic or alkaline, and can corrode and damage the probe after long-time use, shorten the service life of the probe and the like; some coupling agents are easy to dry when in use. In order to improve and enhance the performance of the coupling agent, more and more researchers have been concerned in recent years about the development of the coupling agent, such as chinese patent application publication no: CN 107007848A discloses a medical ultrasonic couplant of disinfection and sterilization type, but the bactericide used in the raw materials of the ultrasonic couplant needs to be specially prepared, which increases the difficulty for the use of the bactericide, and other by-products can be produced in the reaction process, and operations such as purification and the like need to be carried out, so that the utilization rate of the raw materials is generally low. Based on the defects in the prior art, the invention provides the heart color ultrasound coupling agent with rich raw material sources and good sterilization effect.
Disclosure of Invention
The invention aims to solve the defects of poor sterilization effect and scarce raw material sources in the prior art, and provides a heart color ultrasound couplant.
The heart color ultrasound couplant is prepared from the following raw materials in parts by weight: 2-6 parts of aloe juice, 1-3 parts of chitin, 5-7 parts of carbomer, 2.5-3.5 parts of alginate, 2-4 parts of polyethylene glycol, 1.5-2.5 parts of alkyl glucoside, 3-5 parts of ethanol and 100-150 parts of water.
Preferably, the ultrasonic coupling agent is prepared from the following raw materials in parts by weight: 4 parts of aloe juice, 2 parts of chitin, 6 parts of carbomer, 3 parts of alginate, 3 parts of polyethylene glycol, 2 parts of alkyl glucoside, 4 parts of ethanol and 130 parts of water.
Preferably, the mass ratio of the aloe juice to the chitin is 1-3: 1.
preferably, the mass ratio of the carbomer to the alginate is 2: 1, and the alginate is any one of sodium alginate and potassium alginate.
Preferably, the preparation process of the aloe juice comprises the following steps: cleaning fresh aloe, sterilizing by ultraviolet, peeling, pulverizing, filtering with 100 mesh sieve until all aloe passes through the sieve, centrifuging at high speed, collecting supernatant, and mixing to obtain aloe juice.
Preferably, the preparation method of the heart color ultrasound couplant comprises the following steps:
s1, dissolving polyethylene glycol in a corresponding weight part in water in an amount which is 20-30 times the weight of the polyethylene glycol, and uniformly mixing to obtain a mixed solution A;
s2, adding the aloe juice, the chitin, the alkyl glucoside and the ethanol in corresponding parts by weight into the balance of water, and uniformly mixing to obtain a mixed solution B;
s3, mixing the mixed solution A and the mixed solution B, adding carbomer and alginate in corresponding parts by weight, stirring for 10-30 min to obtain a mixture C, adjusting the pH value of the mixture C to 6.5-7.5 by using a pH regulator, and then transferring to a homogenizer for homogenization to obtain the heart color ultrasound couplant.
Preferably, the pH regulator is an aqueous solution of sodium hydroxide, and the mass concentration of sodium hydroxide in the aqueous solution of sodium hydroxide is 3-5%.
Preferably, the homogenizing pressure is 10-40 MPa, and the homogenizing temperature is 4-30 ℃.
The coupling agent provided by the invention has the advantages of rich raw material sources, good antibacterial effect, good wettability and thixotropy, no greasy feeling, no corrosion and damage to skin and probes, difficulty in polluting clothes, easiness in cleaning after use, simple preparation method and low production cost; carbomer and alginate are jointly used as main components of the couplant, the use amount of carbomer is reduced, the production cost is further reduced, aloe juice and chitin in a reasonable proportion are added into raw materials to achieve an excellent antibacterial effect, cross infection in the using process is avoided, polyethylene glycol, alkyl glucoside and ethanol are added to improve the wettability and thixotropy of the couplant, the couplant is easy to spread on the surfaces of a probe and skin and not prone to generate a drying phenomenon after use, the components in the raw materials are good in dissolving effect in water, clothes are not prone to be polluted when the couplant is used, the couplant is easy to clean after use and not prone to adhere to the surfaces of the skin and the probe, damage to the skin and the probe is further reduced, reasonable adjustment of the pH value of the couplant in the preparation process is added, the use safety of the couplant is further guaranteed, and the invention further provides the couplant, which is simple to operate and simple in operation, The method for preparing the coupling agent has low production cost, and the prepared coupling agent has good mixing effect of all raw materials and uniform and stable performance.
Detailed Description
The present invention will be further illustrated with reference to the following specific examples.
Example one
The invention provides a heart color ultrasound couplant which is prepared from the following raw materials in parts by weight: the feed comprises the following raw materials in parts by weight: 4 parts of aloe juice, 2 parts of chitin, 6 parts of carbomer, 3 parts of sodium alginate, 3 parts of polyethylene glycol, 2 parts of alkyl glucoside, 4 parts of ethanol and 130 parts of water;
the preparation method comprises the following steps:
s1, dissolving polyethylene glycol in a weight ratio of 25 times that of water, and uniformly mixing to obtain a mixed solution A;
s2, adding the aloe juice, the chitin, the alkyl glucoside and the ethanol in corresponding parts by weight into the balance of water, and uniformly mixing to obtain a mixed solution B;
s3, mixing the mixed solution A and the mixed solution B, adding carbomer and sodium alginate in corresponding parts by weight, stirring for 20min to obtain a mixture C, adjusting the pH value of the mixture C to 6.5-7.5 by using a sodium hydroxide solution with the mass concentration of 4%, transferring the mixture C into a homogenizer, and homogenizing at the pressure of 20MPa and the temperature of 20 ℃ to obtain the heart color ultrasound couplant.
Example two
The invention provides a heart color ultrasound couplant which is prepared from the following raw materials in parts by weight: 2 parts of aloe juice, 1 part of chitin, 6 parts of carbomer, 3 parts of potassium alginate, 4 parts of polyethylene glycol, 2 parts of alkyl glucoside, 3 parts of ethanol and 120 parts of water;
the preparation method comprises the following steps:
s1, dissolving polyethylene glycol in a corresponding weight part in water in an amount which is 20 times that of the polyethylene glycol, and uniformly mixing to obtain a mixed solution A;
s2, adding the aloe juice, the chitin, the alkyl glucoside and the ethanol in corresponding parts by weight into the balance of water, and uniformly mixing to obtain a mixed solution B;
s3, mixing the mixed solution A and the mixed solution B, adding carbomer and potassium alginate in corresponding parts by weight, stirring for 30min to obtain a mixture C, adjusting the pH value of the mixture C to 6.5-7.5 by using a sodium hydroxide solution with the mass concentration of 3%, then transferring the mixture C into a homogenizer, and homogenizing at the pressure of 10MPa and the temperature of 10 ℃ to obtain the heart color ultrasound couplant.
EXAMPLE III
The invention provides a heart color ultrasound couplant which is prepared from the following raw materials in parts by weight: 6 parts of aloe juice, 2 parts of chitin, 7 parts of carbomer, 3.5 parts of sodium alginate, 2 parts of polyethylene glycol, 1.5 parts of alkyl glucoside, 4 parts of ethanol and 150 parts of water;
the preparation method comprises the following steps:
s1, dissolving polyethylene glycol in a corresponding weight part in 30 times of water by mass, and uniformly mixing to obtain a mixed solution A;
s2, adding the aloe juice, the chitin, the alkyl glucoside and the ethanol in corresponding parts by weight into the balance of water, and uniformly mixing to obtain a mixed solution B;
s3, mixing the mixed solution A and the mixed solution B, adding carbomer and sodium alginate in corresponding parts by weight, stirring for 10min to obtain a mixture C, adjusting the pH value of the mixture C to 6.5-7.5 by using a sodium hydroxide solution with the mass concentration of 5%, then transferring the mixture C into a homogenizer, and homogenizing at the pressure of 40MPa and the temperature of 4 ℃ to obtain the heart color ultrasound couplant.
Comparative example 1
And removing the aloe juice and the chitin in the first embodiment, and preparing the coupling agent under the same conditions.
Comparative example No. two
And removing the chitin from the raw materials of the coupling agent in the first embodiment, and obtaining the coupling agent under the unchanged other conditions.
Comparative example No. three
And (3) removing the aloe juice in the raw materials of the coupling agent in the first embodiment, and obtaining the coupling agent under the same other conditions.
The coupling agents prepared in the first embodiment, the second embodiment and the third embodiment and the first comparative embodiment, the second comparative embodiment and the third comparative embodiment are respectively detected, and the detection results are as follows:
the results of sound velocity, acoustic characteristic impedance and acoustic attenuation coefficient slope show that: the test results of the first, second and third examples are better than those of the first, second and third comparative examples, showing that: the couplant prepared by the formula and the preparation method of the couplant provided by the invention has the advantages of stable performance, high sound velocity, low sound characteristic impedance and low sound attenuation slope coefficient.
The detection result of the sterilization rate shows that: the coupling agents prepared in the first, second and third examples have killing rates of 99% or more on escherichia coli, staphylococcus aureus and candida albicans, and the killing rates of the escherichia coli, staphylococcus aureus and candida albicans are obviously reduced by adding no aloe juice or chitin or only one of the aloe juice and the chitin, which indicates that: the aloe juice and the chitin have a synergistic sterilization effect and are excellent in sterilization effect.
The above description is only for the preferred embodiment of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art should be considered to be within the technical scope of the present invention, and the technical solutions and the inventive concepts thereof according to the present invention should be equivalent or changed within the scope of the present invention.
Claims (6)
1. The heart color ultrasound couplant is characterized by being prepared from the following raw materials in parts by weight: 2-6 parts of aloe juice, 1-3 parts of chitin, 5-7 parts of carbomer, 2.5-3.5 parts of alginate, 2-4 parts of polyethylene glycol, 1.5-2.5 parts of alkyl glucoside, 3-5 parts of ethanol and 100-150 parts of water; the mass ratio of the aloe juice to the chitin is 1-3: 1; the mass ratio of carbomer to alginate is 2: 1, and the alginate is any one of sodium alginate and potassium alginate.
2. The heart color ultrasound couplant according to claim 1, wherein the ultrasound couplant is prepared from the following raw materials in parts by weight: 4 parts of aloe juice, 2 parts of chitin, 6 parts of carbomer, 3 parts of alginate, 3 parts of polyethylene glycol, 2 parts of alkyl glucoside, 4 parts of ethanol and 130 parts of water.
3. The heart color ultrasound couplant of claim 1, wherein the aloe juice is prepared by the following steps: cleaning fresh aloe, sterilizing by ultraviolet, peeling, pulverizing, filtering with 100 mesh sieve until all aloe passes through the sieve, centrifuging at high speed, collecting supernatant, and mixing to obtain aloe juice.
4. The heart color ultrasound couplant of claim 1, 2 or 3, wherein the preparation method comprises the following steps:
s1, dissolving polyethylene glycol in a corresponding weight part in water in an amount which is 20-30 times the weight of the polyethylene glycol, and uniformly mixing to obtain a mixed solution A;
s2, adding the aloe juice, the chitin, the alkyl glucoside and the ethanol in corresponding parts by weight into the balance of water, and uniformly mixing to obtain a mixed solution B;
s3, mixing the mixed solution A and the mixed solution B, adding carbomer and alginate in corresponding parts by weight, stirring for 10-30 min to obtain a mixture C, adjusting the pH value of the mixture C to 6.5-7.5 by using a pH regulator, and then transferring to a homogenizer for homogenization to obtain the heart color ultrasound couplant.
5. The preparation method of the heart color ultrasound couplant according to claim 4, wherein the pH regulator is an aqueous solution of sodium hydroxide, and the mass concentration of the sodium hydroxide in the aqueous solution of sodium hydroxide is 3-5%.
6. The method for preparing the heart color ultrasound couplant according to claim 4, wherein the homogenizing pressure is 10-40 MPa, and the homogenizing temperature is 4-30 ℃.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711276162.8A CN107753961B (en) | 2017-12-06 | 2017-12-06 | Heart color ultrasound coupling agent |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711276162.8A CN107753961B (en) | 2017-12-06 | 2017-12-06 | Heart color ultrasound coupling agent |
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| CN107753961A CN107753961A (en) | 2018-03-06 |
| CN107753961B true CN107753961B (en) | 2020-09-11 |
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Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN109010851A (en) * | 2018-08-24 | 2018-12-18 | 广州恒腾电子科技有限公司 | A kind of couplant for ultrasound detection |
| CN109529062A (en) * | 2019-01-18 | 2019-03-29 | 高文娟 | A kind of Ultrasonography novel couplant |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101711879A (en) * | 2009-11-21 | 2010-05-26 | 日照众生医疗科技有限公司 | Sterilizing medical ultrasonic coupling agent and preparation method thereof |
| CN106075483A (en) * | 2016-08-16 | 2016-11-09 | 青岛云天生物技术有限公司 | A kind of ultrasonic coupling agent for medical ultrasonic diagnosis and treatment and preparation method thereof |
| CN107158414A (en) * | 2017-06-22 | 2017-09-15 | 江苏依柯化工有限公司 | A kind of antibacterial skin-moisturizing medical ultrasonic coupling agent of disinfection and preparation method thereof |
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2017
- 2017-12-06 CN CN201711276162.8A patent/CN107753961B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101711879A (en) * | 2009-11-21 | 2010-05-26 | 日照众生医疗科技有限公司 | Sterilizing medical ultrasonic coupling agent and preparation method thereof |
| CN106075483A (en) * | 2016-08-16 | 2016-11-09 | 青岛云天生物技术有限公司 | A kind of ultrasonic coupling agent for medical ultrasonic diagnosis and treatment and preparation method thereof |
| CN107158414A (en) * | 2017-06-22 | 2017-09-15 | 江苏依柯化工有限公司 | A kind of antibacterial skin-moisturizing medical ultrasonic coupling agent of disinfection and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| Antibacterial activity of chitin, chitosan and its oligomers prepared from shrimp shell waste;M.S. Benhabiles et al.;《Food Hydrocolloids》;20121231;第29卷;第48-56页 * |
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