CN1843124A - Nano silver coating agent for sterilization and its preparation method - Google Patents
Nano silver coating agent for sterilization and its preparation method Download PDFInfo
- Publication number
- CN1843124A CN1843124A CN 200610034392 CN200610034392A CN1843124A CN 1843124 A CN1843124 A CN 1843124A CN 200610034392 CN200610034392 CN 200610034392 CN 200610034392 A CN200610034392 A CN 200610034392A CN 1843124 A CN1843124 A CN 1843124A
- Authority
- CN
- China
- Prior art keywords
- nano silver
- coating agent
- sterilization
- silver coating
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
- A01N59/16—Heavy metals; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/38—Silver; Compounds thereof
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Inorganic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Environmental Sciences (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- Pest Control & Pesticides (AREA)
- Agronomy & Crop Science (AREA)
- Zoology (AREA)
- Plant Pathology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention relates to a nano silver coating agent for sterilization and its preparation method, wherein the film coating agent is prepared from nanometer silver, film-forming agent, plasticizing agent, ethanol and distilled water through the steps of mixing homogeneously, heating and dissolving. The obtained film coating agent has anti-inflammation and antibiotic actions, and can be used for treating burns and scalds.
Description
Technical field
The present invention relates to a kind of nano silver coating agent for sterilization;
The invention still further relates to the preparation method of described nano silver coating agent for sterilization.
Technical background
Nano silver particles belongs to nano noble metal particles, is meant the argent particulate of particle diameter between 1～100nm, is also referred to as the ultra micro noble metal.The excellent properties of Nano Silver material depends on the microstructure that it is unique, nano silver particles has significant skin effect, quantum size effect and macro quanta tunnel effect, thereby demonstrate the characteristics such as biology, heat, light, electricity, magnetic, catalysis and sensitivity that are different from conventional material, make it can be applied to many fields such as biomedicine, optics, electronics, photoelectric material, catalyzer, magnetic material.
Silver just is widely used at biomedical sector since ancient times.In the time immemorial generation, just the someone finds that silver has the function of disinfection.For there being the human silverware to deposit food, prevent bacterial growth in Ancient Chinese; Ancient times, the Phoenician was for fresh-keeping, in the navigation process with silver vessel be filled with water, liquid such as wine, vinegar; Ancient times, the Mediterranean resident also put into wooden buckt to silver coin, stoped the growth of putrefactive microorganisms such as bacterium, marine alga.1893, C.Von Nageli was through systematic research, reported first metal (especially silver) to the lethal effect of bacterium and other unicellular lower eukaryote, make silver might become a kind of disinfectant.
As the Nano Silver of a kind of specific form of argent, in the antibiotic effect of performance silver, because particle is atomic little, surface area is bigger, has superpower activity and stronger tissue permeability, and its bactericidal action is hundreds of times of common silver.In addition, because the surface electronic characteristic of the argent of nanoscale, it can form part with electron withdraw groups such as sulfydryl on the protein of bacteria molecule, amidos, thereby has further strengthened antibacterial effect.Its antibacterial mechanisms is, the argent ion is with after bacterium contacts, Ag
+Can (SH) combine, make the protease loss of activity of cell, cause the cell proper constituent destroyed, produce functional disorder and death, thereby the growth of bacterium and breeding just be inhibited with sulfydryl on the bacterial body protease.After bacterium was killed, silver ion can dissociate out from the bacterium residue, shows the anti-microbial property that it is excellent once more.Therefore, silver ion itself have efficiently, the anti-microbial property of lasting and wide spectrum.
At present, Nano Silver has been widely applied to various medical and anti-biotic materials, as fields such as medical treatment detection, anti-biotic materials.For example, United States Patent (USP) (patent No. 5785972, open day on July 28th, 1998) utilizes Nano Silver and honey and strawflower oil to prepare and a kind ofly prevents to burn and the paste of skin infection after scald, can be coated on the human body wound and protect from infection.Chinese patent (patent No. CN2479951, open day on March 6th, 2002) has prepared a kind of Nano Silver burn and scald and has pasted, and it is by fiber yarn and contain that the Nano Silver yarn crossovers is equidistant, equivalent is made into the mesh-shape fabric, can quicken wound healing, pain relieving, antipruritic, promoting regeneration of tissue for astringency, the flat scar that stays.Chinese patent (patent No. CN2489774; open day on May 8th, 2002) a kind of Adhesive bandage with nm silver fibric layer is disclosed; comprise medical proof fabric layer, absorbed layer, peel off protective layer and Nano Silver tissue layer; can infiltrate subcutaneous bactericidal antiphlogistic effectively; improve the microcirculation of damage surrounding tissue, play analgesia, suppress cell proliferation, eliminate the effect of focus; meet water simultaneously and can further strengthen its activity, strengthen the performance of its sterilizing function.Chinese patent (patent No. CN1672689, open day on September 28th, 2005) a kind of externally used antimicrobial nano silver gel of the women's of treatment LGTI is disclosed, it can pass through vagina administration, as the treatment gynecology colpitis, the medicine of cervicitis or mixed infection, can be used as the medicine of treatment dept. of dermatology or surgical infection, can also be as the antimicrobial component in the cosmetics.
Above-mentioned patent utilization the performance of killing bacterium, fungi of Nano Silver treat burn, scald, wound and dept. of dermatology's disease.Shortcomings such as but all there is preparation method's complexity in said method, uses inconvenience, and use face is narrow.
Summary of the invention
The object of the present invention is to provide a kind of nano silver coating agent for sterilization, be used for antiphlogistic antibacterial, burn, scald, wound are all had better curative effect; can prevent effectively that wound from being infected; the healing of accelerated in wounds, film forming have certain tear resistance, can also play the effect of protection wound.And the energy kill fungi, to significant curative effect being arranged by fungus-caused tinea disease.
The present invention also aims to provide the preparation method of described nano silver coating agent for sterilization.
Nano silver coating agent for sterilization of the present invention is made up of the component of following weight portion:
Distilled water 100
Nano silver powder 0.05-1.00
Film forming agent 8-15
Plasticizer 3-8
Ethanol 40-60.
Described film forming agent, plasticizer adopt the field of medicaments accessory ingredient of in common use, and ethanol adopts medical ethanol.
Preferred version of the present invention is as follows: film forming agent is selected polyvinylpyrrolidone, ethyl cellulose, sodium carboxymethylcellulose, collodion, polyvinyl alcohol or polyvinyl formal acetal for use.
Plasticizer is selected glycerine for use.
The preparation method of described nano silver coating agent for sterilization comprises the steps:
(1) nano silver powder dissolves in the distilled water; Add ethanol, film forming agent, plasticizer, evenly mixed;
(2) be heated to dissolving, obtain yellow translucent viscous solution.
The present invention does not have strict restriction to heating-up temperature, is heated to dissolving and gets final product.
The nano silver coating agent for sterilization for preparing, can suppress bacterium and fungi growth, described bacterium and fungi include but not limited to following kind: salmonella, resistance Escherichia coli, resistance golden staphylococci, drug-resistant pseudomonas aeruginosa, streptococcus pyogenes, resistance enterococcus, anaerobic bacteria, staphylococcus aureus, Escherichia coli, pneumobacillus, Pseudomonas aeruginosa, Candida albicans and other G+, G-pathogenic bacteria, chlamydia trachomatis, gonococcus, candida albicans.
The present invention compared with prior art has following advantage:
The inventive method is simple, and cost is low, and is easy to use, use wide, good effect, effect is lasting.
Embodiment
Embodiment 1
The preparation method: (1) nano silver powder dissolves in the distilled water; Add ethanol, film forming agent, plasticizer, evenly mixed; (2) be heated to dissolving, obtaining yellow translucent viscous solution is plastics.Each component and consumption thereof (gram) are as follows
Distilled water 100
Nano silver powder 0.05
Film forming agent polyvinylpyrrolidone 15
Plasticizer glycerine 3
Medical ethanol 60.
The plastics surface drying time that obtains is 6 minutes.
Embodiment 2
The preparation method is with embodiment 1, and each component and consumption thereof (gram) are as follows
Distilled water 100
Nano silver powder 0.10
Film forming agent sodium carboxymethylcellulose 8
Plasticizer glycerine 8
Medical ethanol 40.
The plastics surface drying time that obtains is 5 minutes.
Embodiment 3
The preparation method is with embodiment 1, and each component and consumption thereof (gram) are as follows
Distilled water 100
Nano silver powder 0.07
Film forming agent collodion 10
Plasticizer glycerine 5
Medical ethanol 50.
The plastics surface drying time that obtains is 8 minutes.
The detection of the minimum inhibitory concentration (MIC) of the nano silver coating agent that embodiment 1,2,3 is obtained
(1) test stone: 2002 editions " disinfection technology standard " 2.1.8 of Ministry of Health of the People's Republic of China lowest bacteria fogging-resistant concentration determining test.
(2) checking procedure:
The preparation of bacteriostatic solution: get the agent of 5g nano silver coating agent with sterile working, put into 45ml Plondrel acid buffer, fully concussion is dissolved, and is made into 10% homodisperse suspension.
1) bacteriostatic agent medium preparation: will be made into 10% anti-suspension and do the test solution that is subjected to that times serial dilution is become variable concentrations with PBS, it is standby to put 45 ℃～50 ℃ constant temperature water baths.
2) double concentration medium preparation: 76gMH agar dehydrated medium is dissolved in the 1000ml water.Be heated to the boiling dissolving.121 ℃ of pressuresteam sterilization 15min then, it is standby to put 45 ℃～50 ℃ water-baths.This medium will be used to dilute antibacterial suspension.
3) contain the antibacterial liquid culture medium preparation: the antibacterial liquid of getting the 10ml serial dilution respectively adds in the plate.Double MH agar 10ml that will be in 45 ℃～50 ℃ water-baths adds in the plate, and the limit edged rocks flat board, makes the abundant mixing of antibacterial liquid and medium.
4) get with sample injector that 1 μ l～(bacteria containing amount is about 10 to 2 μ l
7Cfu/ml) the bacteria suspension dibbling is in the plate that contains the antibacterial liquid medium, and (each some bacterium amount is about 10 to the about 5mm～8mm of the inoculation formed bacterium liquid loop diameter in back
4Cfu).
5) inoculation does not in kind contain the MH agar plate of antipathogenic composition, as positive control.
6) with postvaccinal dull and stereotyped the placement in 35 ℃ of incubators, be inverted and cultivate 18h～24h, observed result.
(3) criterion
The minimum antibacterial liquid concentration that colony growth is suppressed fully is that this sample is to being tried the MIC of bacterium.
(4) measurement result
The minimum inhibitory concentration of nano silver coating agent (MIC) measurement result is as shown in table 1, and wherein the unit of MIC is mg (Nano Silver)/l.
Table 1
| Test microbes | Minimum inhibitory concentration (MIC) (mg/l) | ||
| Colon bacillus ATCC 25922 (Escherichia coli) | Embodiment 1:10 | Embodiment 2:12 | Embodiment 3:15 |
| Candida albicans ATCC 10231 (Candida albicans) | Embodiment 1:20 | Embodiment 2:21 | Embodiment 3:23 |
| Staphylococcus aureus ATCC 10231 (Staphylococcus aureus) | Embodiment 1:25 | Embodiment 2:22 | Embodiment 3:20 |
Above-mentioned testing result shows that the plastics of the present invention's preparation just can have killing action to above-mentioned representational bacterium and fungi under low concentration, do not have toxic and side effect through clinical testing.
Claims (4)
1, a kind of nano silver coating agent for sterilization is characterized in that being made up of the component of following weight portion:
Distilled water 100
Nano silver powder 0.05-1.00
Film forming agent 8-15
Plasticizer 3-8
Ethanol 40-60.
2, nano silver coating agent for sterilization according to claim 1 is characterized in that film forming agent selects polyvinylpyrrolidone, ethyl cellulose, sodium carboxymethylcellulose, collodion, polyvinyl alcohol or polyvinyl formal acetal for use.
3, nano silver coating agent for sterilization according to claim 1 and 2 is characterized in that plasticizer selects glycerine for use.
4, the preparation method of the described nano silver coating agent for sterilization of one of claim 1-3 is characterized in that comprising the steps:
(1) nano silver powder dissolves in the distilled water; Add ethanol, film forming agent, plasticizer, evenly mixed;
(2) be heated to dissolving, obtain yellow translucent viscous solution.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200610034392 CN1843124A (en) | 2006-03-17 | 2006-03-17 | Nano silver coating agent for sterilization and its preparation method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200610034392 CN1843124A (en) | 2006-03-17 | 2006-03-17 | Nano silver coating agent for sterilization and its preparation method |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1843124A true CN1843124A (en) | 2006-10-11 |
Family
ID=37062117
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200610034392 Pending CN1843124A (en) | 2006-03-17 | 2006-03-17 | Nano silver coating agent for sterilization and its preparation method |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1843124A (en) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101073434B (en) * | 2007-06-05 | 2010-08-25 | 山东大学 | Production and use for silver nano-metal antibacterial coating |
| CN102613243A (en) * | 2012-03-12 | 2012-08-01 | 宋信宇 | Nanometer Ag antimicrobial and preparation method thereof |
| CN105326535A (en) * | 2014-08-06 | 2016-02-17 | 北京派尔特医疗科技股份有限公司 | Medical anastomosis nail and preparation method thereof |
| CN107496970A (en) * | 2016-06-14 | 2017-12-22 | 陈明鸿 | Wound dressing film containing nano silver colloid and preparation method thereof |
| CN108078959A (en) * | 2016-11-22 | 2018-05-29 | 北京赛特瑞科技发展有限公司 | A kind of antibacterial and protective film and its preparation method and application |
| CN111449086A (en) * | 2020-05-11 | 2020-07-28 | 武汉工程大学 | Colloidal silver/polymer mixed disinfectant and preparation method and application thereof |
-
2006
- 2006-03-17 CN CN 200610034392 patent/CN1843124A/en active Pending
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101073434B (en) * | 2007-06-05 | 2010-08-25 | 山东大学 | Production and use for silver nano-metal antibacterial coating |
| CN102613243A (en) * | 2012-03-12 | 2012-08-01 | 宋信宇 | Nanometer Ag antimicrobial and preparation method thereof |
| CN105326535A (en) * | 2014-08-06 | 2016-02-17 | 北京派尔特医疗科技股份有限公司 | Medical anastomosis nail and preparation method thereof |
| CN107496970A (en) * | 2016-06-14 | 2017-12-22 | 陈明鸿 | Wound dressing film containing nano silver colloid and preparation method thereof |
| CN108078959A (en) * | 2016-11-22 | 2018-05-29 | 北京赛特瑞科技发展有限公司 | A kind of antibacterial and protective film and its preparation method and application |
| CN111449086A (en) * | 2020-05-11 | 2020-07-28 | 武汉工程大学 | Colloidal silver/polymer mixed disinfectant and preparation method and application thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Naseri-Nosar et al. | Wound dressings from naturally-occurring polymers: A review on homopolysaccharide-based composites | |
| Liang et al. | Facile synthesis of ZnO QDs@ GO-CS hydrogel for synergetic antibacterial applications and enhanced wound healing | |
| Shariati et al. | Graphene-based materials for inhibition of wound infection and accelerating wound healing | |
| Mirhaj et al. | An overview on the recent advances in the treatment of infected wounds: Antibacterial wound dressings | |
| JP2015529643A (en) | Physical antimicrobial method | |
| CN107185031B (en) | A kind of biologically active medical dressing and preparation method thereof | |
| WO2019169873A1 (en) | Nano antibacterial gel for treating wound infection and promoting healing and preparation method therefor | |
| CN101366969B (en) | Uses of zinc oxide as reinforcing agent of chitosan biomembrane | |
| CN111001002A (en) | Polydopamine-coated Prussian blue silver-loaded nano composite material and preparation method and application thereof | |
| CN1843124A (en) | Nano silver coating agent for sterilization and its preparation method | |
| EP3735218B1 (en) | Coordination complexes having microbial activity and incorporable in hyaluronic acid compositions | |
| CN107254742A (en) | The composite fiber web of polyvinyl alcohol/sericin containing Nano Silver for medical dressing | |
| Xu et al. | Mild heat-assisted polydopamine/alginate hydrogel containing low-dose nanoselenium for facilitating infected wound healing | |
| CN111068103B (en) | Long-acting antibacterial gel dressing for operation wound and preparation method thereof | |
| CN105169464B (en) | A kind of natural honey wound dressing and preparation method and application | |
| CN113018499A (en) | Preparation method of ozone oil-water gel composite application capable of sterilizing, resisting virus and absorbing moisture | |
| CN109432483B (en) | Medical dressing for accelerating wound healing and preparation method and application thereof | |
| CA2692094C (en) | Antimicrobial compositions | |
| CN1857309A (en) | Nano silver spray for women and its preparing method | |
| Yang et al. | Electron transfer driven highly valent silver for chronic wound treatment | |
| EP3656404A1 (en) | Film for topical use for treating skin lesions and method for producing and applying same | |
| CN1583165A (en) | Gel gent of Chiense forest frog bactericidal peptide | |
| CN107595819A (en) | A kind of Nano diamond modified liquid adhesive bandage and preparation method thereof | |
| Karayel et al. | Antimicrobial wound dressing materials | |
| Haidari et al. | Antibacterial hydrogel therapy for eradication of wound associated polymicrobial biofilms |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |