CN104983589B - A kind of self-microemulsifying drug delivery and preparation method thereof of natural plants anti-corrosion, antibacterial liquid - Google Patents
A kind of self-microemulsifying drug delivery and preparation method thereof of natural plants anti-corrosion, antibacterial liquid Download PDFInfo
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Abstract
The present invention relates to a kind of natural plants anti-corrosion, the self-microemulsifying drug deliveries and preparation method thereof of antibacterial liquid.The self-microemulsifying drug delivery is made including following components：Plant extracts, emulsifier, assistant for emulsifying agent and pure water.Beneficial effects of the present invention are：The present invention uses plant extracts realizing anti-corrosion, antibacterial effect, while have effects that health-care and skin-care as anti-corrosion, antipathogenic composition.
Description
Technical field
The invention belongs to cosmetic additive agent fields, and in particular to a kind of natural plants anti-corrosion, antibacterial liquid self-emulsifying microemulsion
Liquid and preparation method thereof.
Background technology
Cosmetics are almost required for addition efficacy active component, but most of efficacy active component is difficult quilt in skin surface
It absorbs, can efficacy active component be had become the important determinant for determining cosmetics quality by absorption；Even if in addition, makeup
Product efficacy active component can be absorbed by the skin, and it is just effective also to need to reach a certain amount, and the effect of usually in cosmetics activity into
The structure divided is more complicated, and solubility is smaller to be extremely difficult to corresponding effective concentration, and efficacy active component solubilising has become this kind of system
The important technical barrier of agent.
Therefore how solution product, which research and develop these technical barriers faced in preparation process, becomes cosmetics research staff's
Research hotspot.
On the other hand, often containing nutriments such as protein, amino acid, vitamins in cosmetics, these nutritional ingredients are just
It is the matrix of the microbial growths such as bacterium, fungi procreation.In order to avoid or reduce cosmetics microorganism in production and use
Pollution problem often adds in preservative in cosmetics.
At present, most preservatives used are mostly halogen preservative, Form aldehyde release class preservative, acid in cosmetics
Property preservative etc..But with the development of science and technology, people gradually have found that above-mentioned common preservative often has larger secondary work
With as p-hydroxybenzoate can lead to contact dermatitis；Triclosan has carcinogenesis, this leads to making in life skin care item
With also often will appear toxicity allergy in the process, metabolism of pigment is disorderly the problems such as.
As people's living standard increasingly improves, the security requirement of skin care item preservative is also increasingly paid close attention to.Meanwhile
Desirably, cosmetics preservative simultaneously, while has effects that health-care and skin-care in realization anti-corrosion, antibacterial effect, so,
A kind of safety, preservative that is natural and having effects that health-care and skin-care are urgently developed.
Invention content
In order to solve the above problem of the existing technology, the present invention provides a kind of natural plants anti-corrosion, antibacterial liquids
Self-microemulsifying drug delivery and preparation method thereof.The present invention can solve that efficacy active component solubility is low in cosmetics, bioavailability is low
The problem of, and a kind of safety, natural and have effects that the preservative of health-care and skin-care is provided.
The technical solution adopted in the present invention is：The self-microemulsifying drug delivery of a kind of natural plants anti-corrosion, antibacterial liquid, including following
Component is made：Plant extracts, emulsifier, assistant for emulsifying agent and pure water.
Preferably, the plant extracts by radix jurineae volatile oil, tarragon essential oil, Vitex negundo var cannabifolia leaf volatile oil, sweet wormwood volatile oil,
Two or more arbitrary component in tea tree ethereal oil, thyme extract and Chinese holly leaf extract is made.
The present invention uses natural plant extracts as anti-corrosion, antibacterial substance, and plant extracts is playing anti-corrosion, antibacterial
Effect simultaneously, side effect is significantly less than existing common preservative, meanwhile, plant extracts also has effects that health-care and skin-care,
It can play the role of achieving many things at one stroke.
Preferably, the emulsifier is nonionic surfactant.
Further, the nonionic surfactant is sapn and/or tween.
It is further preferred that the nonionic surfactant is Arlacel-80 and/or Tween-80.
Preferably, the assistant for emulsifying agent is chain alcohol.
It is further preferred that the chain alcohol is 1,2-PD or polyethylene glycol.
Further, a kind of natural plants anti-corrosion, antibacterial liquid self-microemulsifying drug delivery, the parts by weight of each component are：River wood
Fragrant 1~10 part of volatile oil, 1~10 part of tarragon essential oil, 1~10 part of Vitex negundo var cannabifolia leaf volatile oil, 1~10 part of sweet wormwood volatile oil, tea tree essence
1~10 part of oil, 1~5 part of thyme extract, 1~10 part of Chinese holly leaf extract, sapn and/or polysorbas20~100, chain alcohol 10
~20 parts, 60~300 parts of pure water；It should be noted that the plant extracts is by radix jurineae volatile oil, tarragon essential oil, Vitex negundo var cannabifolia
In leaf volatile oil, sweet wormwood volatile oil, tea tree ethereal oil, thyme extract and Chinese holly leaf extract it is arbitrary two or more
Component is made, and it is not absolutely required to whole uses, can adjust the presence or absence of component and dosage as needed.
It is further preferred that the self-microemulsifying drug delivery of a kind of natural plants anti-corrosion, antibacterial liquid, the parts by weight of each component are：
5 parts of radix jurineae volatile oil, 5 parts of tarragon essential oil, 5 parts of Vitex negundo var cannabifolia leaf volatile oil, 5 parts of sweet wormwood volatile oil, 5 parts of tea tree ethereal oil, thyme
3 parts of extract, 5 parts of Chinese holly leaf extract, sapn and/or polysorbate60 part, 15 parts of chain alcohol, 150 parts of pure water；It should be noted that
The plant extracts is by radix jurineae volatile oil, tarragon essential oil, Vitex negundo var cannabifolia leaf volatile oil, sweet wormwood volatile oil, tea tree ethereal oil, thyme
Two or more arbitrary component in extract and Chinese holly leaf extract is made, and it is not absolutely required to whole uses, can root
According to needing to adjust the presence or absence of component.
Method also provides for a kind of preparation methods of the self-microemulsifying drug delivery, include the following steps：
1) preparation of oil mixture：It will be uniformly mixed except the other plant extract of Chinese holly leaf extract, obtain oil phase
Mixture；
2) preparation of mixture I：Emulsifier is slowly added into the oil mixture, is stirring evenly and then adding into pure water,
Mixture I is obtained after stirring evenly；
3) preparation of aqueous mixture：When there is Chinese holly leaf extract in component, the assistant for emulsifying agent, holly leaf are extracted
Liquid and pure water are uniformly mixed, and obtain aqueous mixture；When there is no Chinese holly leaf extract in component, by the assistant for emulsifying agent and pure
Water is uniformly mixed, and obtains aqueous mixture；
4) prepared by finished product：The aqueous mixture is added in the mixture I, is stirred evenly；Then heating heating,
Carry out successively again homogeneous, it is closed, naturally cool to room temperature and obtain finished product.
Preferably, the step 2) is slowly added to emulsifier into the oil mixture, is stirring evenly and then adding into pure water,
40~60min is stirred at 35 DEG C, mixture I is obtained after stirring evenly；Aqueous mixture is added to described by the step 4)
In mixture I, using electrodeless constant speed stirrer, 40~60min is stirred at 35 DEG C, 55~60 DEG C is then heated to, reuses
10~12min of high cut disperse emulsification agent homogeneous；Stir speed (S.S.) is 10000~16000rpm；Then it is closed, naturally cool to room
Temperature obtains finished product.
The present invention also provides a kind of application of self-microemulsifying drug delivery described above in cosmetics are prepared.
To solve the problems, such as indissoluble of the efficacy active component in cosmetics, present invention uses self-emulsifying microemulsion technology, from micro-
Emulsification is a kind of by oil phase, and the preparation technique of emulsifier, assistant for emulsifying agent and water phase composition, self-emulsifying microemulsion technology is since it is with very
Good solubilization can provide good technology solution for the substances solubilising such as cosmetic active object, essence and essential oil.At this
In invention, final finished product is " oil-in-water " system, and the diameter of the oil droplet in system is about 100nm, which can spontaneously form
And thermodynamically stable microemulsion, therefore self-emulsifying microemulsion technology has in industries such as medicine, food, cosmetics and is widely applied very much,
And application prospect is good.
The solubility of essence and essential oil is smaller, but the amount of essence and essential oil needs to reach a certain concentration just in some products
Product effect can be played, but the solvent of some solubilisings can reduce product quality.Therefore, how product quality had not only been ensured but also can play
The effect of essence and essential oil is the difficult point of essence and essential oil addition class product development.Inventor by research, find using it is non-from
Sub- surfactant and chain alcohol composition system can greatly increase solubility of the plant extracts such as essential oil in cosmetics and
Bioavailability plays good effect.
By the way that self-emulsifying microemulsion technology is applied to cosmetic additive agent field, inventor has found to use self-emulsifying microemulsion technology system
Solubility of the standby micro emulsion cosmetics with stability height, efficacy active component is high, the grain size of efficacy active component is small,
Preservative efficacy is more preferable, is easily absorbed by the skin, the advantages that feel is fine and smooth, and the solubility for cosmetic industry active constituent is small, difficult
The problems such as absorption, provides good solution.
It should be strongly noted that due to present invention uses self-emulsifying microemulsion technology, so as to obtain the oil of smaller particle
Drop, it is obvious that smaller grain size means that the specific surface area of bigger, thus the plant extracts in this method, i.e.,
Anti-corrosion, antipathogenic composition, it is also bigger with the contact area of extraneous ingredient for microcosmic go up, so, anti-corrosion, antibacterial effect
More preferably.
In addition, the present invention is big to solve the problems, such as traditional anti-corrosion, bacteriostatic agent side effect, the present invention provides a kind of safety, day
So and there is the anti-corrosion of health-care and skin-care, bacteriostatic agent, wherein anti-corrosion, antipathogenic composition are mainly used as by plant extracts,
The pharmacological property of each component is as follows：
Radix jurineae volatile oil is the extract of radix jurineae, and radix jurineae (Dolomiaea souliei), is both Chinese medicine and Tibetan
Medicine, radix jurineae root contain volatile oil, have good sterilization, bacteriostasis.To staphylococcus aureus, shigella dysenteriae, green pus bar
Bacterium has inhibiting effect, has antibacterial, bactericidal effect to gram-negative bacteria, saccharomycete, the antibacterial, bactericidal effect especially to gram positive bacteria
It is stronger.It can be used as antiseptic, preservative, anti-inflammatory agent in cosmetics；And have strong inhibiting effect to B-16 melanocytes,
Available for whitening product.
Estragon oil is the extract of tarragon (Artemisia dracunculus), and 60-70% containing esdragol has very strong
Fungistatic effect.There is antifungic action, and unicellular to Diplococcus pneumopniae, alpha streptococcus, catalin diplococcus, the pungent bacterium of Yale, vacation
Bacillus, staphylococcus aureus have very strong inhibiting effect.In addition there is effect to B-16 cell Proliferations, so available for cosmetics
Whitening product；There is proliferation function to fibrous bud, so the collagen content in skin corium can be improved, for the anti-of cosmetics
It declines and wrinkle resistant product.
Vitex negundo var cannabifolia leaf volatile oil is the extract of leaf of negundo chastetree (Vitex negundo), is a kind of natural antibacterial agent, to golden yellow
Staphylococcus, Escherichia coli, beta streptococcus, shigella dysenteriae, Pseudomonas aeruginosa have antibacterial action.Leaf of negundo chastetree is by German certification office
Approval is used for the treatment of skin and mucosa class disease.Vitex negundo var cannabifolia leaf volatile oil disappears to the elimination of superoxide radical and to hydroxyl radical free radical
Removing solid capacity can be used for the anti-ageing product of cosmetics.
Sweet wormwood volatile oil is the extract of sweet wormwood (Artemisia carvifolia), has broad spectrum antibacterial, tool sterilization
Effect, has stronger bacteriostasis to staphylococcus epidermis, micrococcus catarrhalis.There is sterilization to make all dermatophytes during 1% concentration
With.In addition sweet wormwood extracting solution coating skin conductance measurement Value Data shows that the water content of cuticula can be substantially improved.So in addition to
Outside anti-corrosion function, at the same time as the moisturizer of cosmetics.
Tea tree ethereal oil (Melaleuca alternifolia) has all natural antimicrobial acivity, biocidal efficacies, resists
Bacterium is active, nonirritant, separately there is excellent Cutaneous permeation effect and unique armaticity.It can treat-cut wiping
Wound, very fast with rear wound healing, hemostasis power is superpower, acne and sore, whelk, mosquito bite, trick tinea etc., to seasick carsick symptom
Also it is effective in cure, it can be with fixed attention.
The extracting solution of holly leaf (Ilex cornuta) has strong antifungal activity, especially to unicellular fungi candida albicans
Inhibiting effect is preferable.In addition Chinese holly leaf extract has inhibiting effect to acyl CoA cholesterol ester acyltransferases, available for class of losing weight
The application of cosmetics.
Thyme (Thymus vulgaris) extract has very strong bactericidal effect, in addition to gold-coloured staphylococci, large intestine
Bacillus has inhibiting effect.Thyme extract has well to the inhibition of hyaluronidase simultaneously, the moisturizing available for skin
Agent.
In actual use, pass through the compounding for needing to carry out plant extracts of different cosmetics, the First Principles of compounding
Exactly it is consistent with the smell of cosmetics in itself, secondly from inhibiting bacteria, inhibiting multiple angle anti-corrosions such as fungi, antibacterial.Pass through
The synergistic effect of two or more plant extracts plays good, wide spectrum anti-corrosion, fungistatic effect, simultaneously as planting
The natural health function of object extract can play the role of enhancing to the active constituent of cosmetics.
For example for Mint toothpaste, tarragon essential oil, Vitex negundo var cannabifolia leaf volatile oil, tea tree ethereal oil, thyme extract etc. can be compounded
Cook preservative.Tarragon essential oil stresses to inhibit antifungal effect；Leaf of negundo chastetree stresses to inhibit bacteria effect, and has both auxiliary reparation oral cavity and glue
Film acts on；Tea tree ethereal oil stresses antimicrobial；Thyme extract plays bactericidal effect, and such anti-corrosion is comprehensive.And these are put
The first two amount is slightly more together, latter two amount is on the low side, it is ensured that the identification of mint aroma does not influence the flavor characteristics of product.
Lavender man clarity oil-control matifying lotion for another example can compound Chinese holly leaf extract, tea tree ethereal oil.In addition, radix jurineae can
For compounding in the product for having Radix Aucklandiae smell, sweet wormwood lays particular emphasis on compounding in the product containing Chinese medical extract；Holly leaf is laid particular emphasis on
The compounding anti-corrosion of aqua product.
Beneficial effects of the present invention are：
1st, the present invention increases the solubility of the plant extracts in cosmetics such as essential oil by providing a kind of self-microemulsifying drug delivery
And bioavailability, play good effect.
2nd, the present invention uses plant extracts realizing anti-corrosion, antibacterial effect simultaneously, tool as anti-corrosion, antipathogenic composition
There is the effect of health-care and skin-care.
Specific embodiment
With reference to embodiment, present disclosure is further illustrated.It should be appreciated that the implementation of the present invention is not limited to
In the following examples, the accommodation in any form and/or change made to the present invention fall within the scope of the present invention.
In the present invention, if not refering in particular to, all parts, percentage are unit of weight, and all equipment and raw material etc. are equal
It is commercially available or the industry is common.Method in following embodiments is the routine of this field unless otherwise instructed
Method.
Embodiment 1
A kind of self-microemulsifying drug delivery of natural plants anti-corrosion, antibacterial liquid, it is composed of the following components：Radix jurineae volatile oil 1g, dragon
Wormwood artemisia essential oil 1g, Vitex negundo var cannabifolia leaf volatile oil 1g, sweet wormwood volatile oil 1g, tea tree ethereal oil 1g, thyme extract 1g, Chinese holly leaf extract
The Arlacel-80 of 1g, 10g, the Tween-80 of 10g, 1,2-PD 10g, pure water 60g.
Embodiment 2
A kind of self-microemulsifying drug delivery of natural plants anti-corrosion, antibacterial liquid, it is composed of the following components：Radix jurineae volatile oil 10g, dragon
Wormwood artemisia essential oil 10g, Vitex negundo var cannabifolia leaf volatile oil 10g, sweet wormwood volatile oil 10g, tea tree ethereal oil 10g, thyme extract 5g, holly leaf extraction
The Arlacel-80 of liquid 10g, 50g, the Tween-80 of 50g, 1,2-PD 20g, pure water 300g.
Embodiment 3
A kind of self-microemulsifying drug delivery of natural plants anti-corrosion, antibacterial liquid, it is composed of the following components：Radix jurineae volatile oil 5g, dragon
Wormwood artemisia essential oil 5g, Vitex negundo var cannabifolia leaf volatile oil 5g, sweet wormwood volatile oil 5g, 5g parts of tea tree ethereal oil, thyme extract 3g, Chinese holly leaf extract
5g parts, the Arlacel-80 of 25g, the Tween-80 of 25g, 1,2-PD 15g, pure water 150g.
Embodiment 4
A kind of self-microemulsifying drug delivery of natural plants anti-corrosion, antibacterial liquid, it is composed of the following components：Radix jurineae volatile oil 10g, dragon
Wormwood artemisia essential oil 10g, sweet wormwood volatile oil 10g, tea tree ethereal oil 10g, thyme extract 5g, the Arlacel-40 of 50g, 1,2-PD
20g, pure water 300g.
Embodiment 5
A kind of self-microemulsifying drug delivery of natural plants anti-corrosion, antibacterial liquid, it is composed of the following components：Tarragon essential oil 5g, leaf of negundo chastetree
Volatile oil 5g, 5g parts of tea tree ethereal oil, 5g parts of Chinese holly leaf extract, the Arlacel-60 of 25g, the Tween-60 of 25g, 15g poly- second two
Alcohol -400, pure water 150g.
Embodiment 6
A kind of self-microemulsifying drug delivery of natural plants anti-corrosion, antibacterial liquid, it is composed of the following components：It is radix jurineae volatile oil 10g, male
Chaste tree leaf volatile oil 10g, sweet wormwood volatile oil 10g, thyme extract 5g, the Tween-60 of Chinese holly leaf extract 10g, 50g, 20g
Polyethylene glycol-400, pure water 300g.
The preparation method of wherein Examples 1 to 6 is：
1) preparation of oil mixture：It will directly be mixed except the other plant extract of Chinese holly leaf extract using conventional method
It closes uniformly, obtains oil mixture；
2) preparation of mixture I：Emulsifier is slowly added into the oil mixture, is stirring evenly and then adding into pure water,
40~60min is stirred at 35 DEG C, mixture I is obtained after stirring evenly；
3) preparation of aqueous mixture：When there is Chinese holly leaf extract in component, the assistant for emulsifying agent, holly leaf are extracted
Liquid and pure water are directly uniformly mixed using conventional method, obtain aqueous mixture；When not there is Chinese holly leaf extract in component,
The assistant for emulsifying agent and pure water directly using conventional method are uniformly mixed, obtain aqueous mixture；
4) prepared by finished product：Aqueous mixture is added in the mixture I, the aqueous mixture and the mixture
I is 35 DEG C, using electrodeless constant speed stirrer, 40~60min is stirred at 35 DEG C, " oil-in-water " system is obtained, then heats up
To 55~60 DEG C, 10~12min of high cut disperse emulsification agent homogeneous is reused；Stir speed (S.S.) is 10000~16000rpm.Then
It is closed, naturally cool to room temperature and obtain finished product.The self-microemulsifying drug delivery of i.e. a kind of natural plants anti-corrosion, antibacterial liquid.
Applicant measures the bacteriostatic activity of preservative of the present invention using paper disk method, and specific experiment process is as follows：
1st, test method
Escherichia coli (8099), staphylococcus aureus (ATCC6538) are inoculated with cultured solution of broth respectively, at 37 DEG C
Culture is for 24 hours；Candida albicans (ATCC10231) inoculation is husky to protect weak fluid nutrient medium, and 5d is cultivated at 25 DEG C；Aspergillus niger
(ATCC16404) Cha Shi fluid nutrient mediums are inoculated with, 6d is cultivated at 25 DEG C.It is with physiological saline that four kinds of bacterial cultures difference are dilute
It is interpreted into a concentration of 106The bacteria suspension of CFU/ml.
To compare, comparative example 1 is set：By a kind of pure natural anti-corrosion for cosmetics disclosed in CN103494741A
Agent is made of the component of following parts by weight：1~3 part of lotus leaf, 3~5 parts of honeysuckle, 2~5 parts of ginkgo leaf, 1~3 part of dark plum, shaddock
Sub- 1~5 part of skin.
Above-mentioned four kinds of bacteria suspensions are coated on nutrient agar panel respectively with aseptic cotton carrier, lawn is made, then cut-off
Diameter is the sterilizing filter paper disk of 3cm, after uniformly picking preservative made of Examples 1 to 4 and comparative example 1 respectively, then is pasted respectively
Made of four kinds of different bacteria suspensions on tablet.For 24 hours, fungal culture 5d observes result to Bacteria Culture.
2nd, evaluation method：
Paper disk method bacteriostatic diameter >=10mm is effective, and bacteriostatic diameter ＜ 10mm are invalid.
3rd, result of the test is shown in Table 1
1 paper disk method preservative fungistatic effect of table
As seen from the above table, preservative made from Examples 1 to 4 has four kinds of bacteriums obvious inhibiting effect, and apparent good
Preservative in comparative example 1.
The present invention is not limited to above-mentioned preferred forms, anyone can show that other are various under the enlightenment of the present invention
The product of form, however, make any variation in its shape or structure, it is every that there is skill identical or similar to the present application
Art scheme, is within the scope of the present invention.
Claims (9)
1. the self-microemulsifying drug delivery of a kind of natural plants anti-corrosion, antibacterial liquid, which is characterized in that be made of following components：Plant extract
Object, emulsifier, assistant for emulsifying agent and pure water；
The plant extracts is made of the component of following parts by weight：1~10 part of radix jurineae volatile oil, 1~10 part of tarragon essential oil,
1~10 part of Vitex negundo var cannabifolia leaf volatile oil, 1~10 part of sweet wormwood volatile oil, 1~10 part of tea tree ethereal oil, 1~5 part of thyme extract, Chinese holly
1~10 part of leaf extract.
2. self-microemulsifying drug delivery according to claim 1, which is characterized in that the emulsifier is nonionic surfactant.
3. self-microemulsifying drug delivery according to claim 2, which is characterized in that the nonionic surfactant for sapn and/
Or tween.
4. self-microemulsifying drug delivery according to claim 3, which is characterized in that the assistant for emulsifying agent is chain alcohol.
5. self-microemulsifying drug delivery according to claim 4, which is characterized in that the parts by weight of its each component are：Radix jurineae is volatilized
1~10 part of oil, 1~10 part of tarragon essential oil, 1~10 part of Vitex negundo var cannabifolia leaf volatile oil, 1~10 part of sweet wormwood volatile oil, tea tree ethereal oil 1~10
Part, 1~5 part of thyme extract, 1~10 part of Chinese holly leaf extract, sapn and/or polysorbas20~100 part, chain alcohol 10~20
Part, 60~300 parts of pure water.
6. self-microemulsifying drug delivery according to claim 4, which is characterized in that the parts by weight of its each component are：Radix jurineae is volatilized
Oil 5 parts, 5 parts of tarragon essential oil, 5 parts of Vitex negundo var cannabifolia leaf volatile oil, 5 parts of sweet wormwood volatile oil, 5 parts of tea tree ethereal oil, 3 parts of thyme extract,
5 parts of Chinese holly leaf extract, sapn and/or polysorbate60 part, 15 parts of chain alcohol, 150 parts of pure water.
7. a kind of preparation method according to any self-microemulsifying drug deliveries of claim 1-6, which is characterized in that including following step
Suddenly：
1) preparation of oil mixture：It will be uniformly mixed except the other plant extract of Chinese holly leaf extract, obtain oil phase mixing
Object；
2) preparation of mixture I：Emulsifier is slowly added into the oil mixture, is stirring evenly and then adding into pure water, is stirred
Mixture I is obtained after uniformly；
3) preparation of aqueous mixture：When there is Chinese holly leaf extract in component, by the assistant for emulsifying agent, Chinese holly leaf extract and
Pure water is uniformly mixed, and obtains aqueous mixture；When not having Chinese holly leaf extract in component, the assistant for emulsifying agent and pure water are mixed
It closes uniformly, obtains aqueous mixture；
4) prepared by finished product：The aqueous mixture is added in the mixture I, is stirred evenly；Then heating heating, then according to
Secondary progress homogeneous, it is closed, naturally cool to room temperature and obtain finished product.
8. a kind of preparation method according to claim 7, which is characterized in that the step 2) is into the oil mixture
Emulsifier is slowly added to, is stirring evenly and then adding into pure water, 40~60min is stirred at 35 DEG C, mixture is obtained after stirring evenly
Ⅰ；Aqueous mixture is added in the mixture I by the step 4), and using electrodeless constant speed stirrer, 40 are stirred at 35 DEG C
~60min then heats to 55~60 DEG C, reuses 10~12min of high-shearing dispersion emulsifying machine homogeneous；Stir speed (S.S.) is
10000~16000rpm；Then it is closed, naturally cool to room temperature and obtain finished product.
9. a kind of application according to one of the claim 1-6 self-microemulsifying drug deliveries in cosmetics are prepared.
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| CN107281012A (en) * | 2017-07-25 | 2017-10-24 | 佛山市绿植生物科技有限公司 | A kind of mosquito-driving liquid and preparation method thereof |
| CN108030711A (en) * | 2017-12-18 | 2018-05-15 | 东莞俏美肌生物科技有限公司 | Skin whitening care cosmetics |
| CN110742827A (en) * | 2019-09-27 | 2020-02-04 | 华南师范大学 | Anticorrosive composition and application thereof |
| CN113773910B (en) * | 2021-09-30 | 2022-11-08 | 梵申兰科技(上海)有限公司 | Artemisia annua essential oil and white tea essential oil for promoting skin cell regeneration and their composition |
| CN114522133B (en) * | 2022-02-26 | 2023-06-16 | 上海应用技术大学 | Antibacterial microemulsion, preparation method and application thereof, moisturizing water, moisturizing emulsion, moisturizing cream and preparation method thereof |
| CN114668147A (en) * | 2022-03-25 | 2022-06-28 | 华南农业大学 | Melaleuca alternifolia compound essential oil microemulsion and preparation method thereof |
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| CN101703457A (en) * | 2009-11-25 | 2010-05-12 | 李俊彦 | Bamboo leaf antiageing skin-nourishing mask |
| CN102845512A (en) * | 2012-07-28 | 2013-01-02 | 海南大学 | Water-soluble tea tree oil/chitosan antibacterial compound |
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| CN104983589A (en) | 2015-10-21 |
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