CN103494713A - Composition with antiseptic efficacy and application thereof in cosmetics - Google Patents
Composition with antiseptic efficacy and application thereof in cosmetics Download PDFInfo
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- CN103494713A CN103494713A CN201310482008.1A CN201310482008A CN103494713A CN 103494713 A CN103494713 A CN 103494713A CN 201310482008 A CN201310482008 A CN 201310482008A CN 103494713 A CN103494713 A CN 103494713A
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- hexanediol
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Abstract
The invention discloses a composition with antiseptic efficacy. The composition is characterized by being composed of, by weight, 10-80% of 1,2-octandiol, 10-80% of 1,2-hexanediol and 1-30% of potentiating agent, the potentiating agent in the composition is one or multiple of tropolone, ethylhexylglycerin, 1,2-propandediol, 1,3-butanediol and 1,2-pentanediol. A preparation method of the composition includes mixing 1,2-octandiol, 1,2-hexanediol and the potentiating agent, stirring for uniformly dissolving, and obtaining the composition. The composition has good antiseptic effect, and utilized raw materials are all safe and nonirritant compounds and are free of damage to human skin, so that the defect that existing antiseptic is serious in damage to the human skin is overcome. In addition, polyalcohol in the composition has good moisturizing efficacy.
Description
Technical field
The present invention relates to a kind of anticorrosive composite and application, a kind of glycol composition with preservative efficacy reaches the application in cosmetics specifically.
Background technology
Contain abundant nutrient pledge in cosmetics, be particularly suitable for growth of microorganism, so need to add antiseptic in cosmetics.Adding the purpose of antiseptic at cosmetics is exactly in order to suppress growth of microorganism and generation, avoids cosmetics produce denaturalization phenomenon and maintain freshness and lasting effect.
67 kinds of antiseptic and use thereof that China cosmetics health planning (2007 editions) has stipulated in cosmetics, to use are limited the quantity of.At present, in cosmetics, antiseptic commonly used has p-Hydroxybenzoate, imidazolidinyl urea, interior uride, isothiazolone, phenyl phenol etc.These antiseptic have certain injury to human body skin, easily cause skin allergy.So, study and use non-stimulated, safe antiseptic actives to become the focus of cosmetics research.
Summary of the invention
Purpose of the present invention just is to provide a kind of non-stimulated, safe glycol composition with preservative efficacy.
To achieve the object of the present invention, the present invention has adopted following technical scheme:
A kind of compositions with preservative efficacy is characterized in that the component that comprises following percentage by weight: 1,2-ethohexadiol 10-80%, 1,2-hexanediol 10-80%, synergist 1-30%.
In above-mentioned composition, synergist is tropolone, Sensiva SC50,1,2-PD, 1,3 butylene glycol, 1, one or more in the 2-pentanediol.
The above-mentioned preparation method with compositions of preservative efficacy is characterized in that: by 1,2-ethohexadiol, 1,2-hexanediol, synergist mix, and stirring and dissolving is even, gets final product.
The second purpose of the present invention be by the above-mentioned compositions with preservative efficacy for cosmetics, make stable in properties, cosmetics that antiseptic effect is good.
For realizing the second purpose of the present invention, the present invention has adopted following technical scheme: by the above-mentioned compositions with preservative efficacy for preparing cosmetics, it is characterized in that in anti-aging cosmetics containing the above-mentioned compositions with preservative efficacy, its consumption is 0.02-5%, and preferable amount is 0.1-2%.
The dosage form of cosmetics is not particularly limited, and can be solution, emulsion, paste, foundation emulsion, spray, facial film etc.
The invention has the beneficial effects as follows: compositions of the present invention has good antiseptic effect, and raw material used is all some safe, non-stimulated compounds, and human body skin, without injury, has been overcome current antiseptic human body skin is injured to large defect.In addition, the polyhydric alcohol in compositions also has good moisture-keeping efficacy.
The specific embodiment
Below come by specific embodiment that the present invention is further illustrated, but these embodiment are not limitations of the present invention just in order to illustrate.
embodiment 1 has compositions (I) of preservative efficacy and preparation method thereof
Compositions (I) with preservative efficacy is composed as follows by weight percentage: 1,2-ethohexadiol 40%, 1,2-hexanediol 50%, tropolone 10%.
Preparation method is: by 1,2-ethohexadiol, 1,2-hexanediol, tropolone mix, and stirring and dissolving is even, gets final product.
embodiment 2?
there is compositions (II) of preservative efficacy and preparation method thereof
Compositions (II) with preservative efficacy is composed as follows by weight percentage: 1,2-ethohexadiol 40%, 1,2-hexanediol 48%, Sensiva SC50 12%.
Preparation method is: by 1,2-ethohexadiol, 1,2-hexanediol, Sensiva SC50 mix, and stirring and dissolving is even, gets final product.
embodiment 3?
there is compositions (III) of preservative efficacy and preparation method thereof
Compositions with preservative efficacy
(III)composed as follows by weight percentage: 1,2-ethohexadiol 45%, 1,2-hexanediol 38%, Sensiva SC50 12%, 1,2-pentanediol 5%.
Preparation method is: by 1,2-ethohexadiol, 1,2-hexanediol, Sensiva SC50, pentanediol mix, and stirring and dissolving is even, gets final product.
embodiment 4 cold cream frosts
Table 1 provides and does not contain the cold cream frost formula with compositions of preservative efficacy of the present invention.
Table 1
Preparation method: A is 80 ℃ of dissolving mix homogeneously mutually, and B is 80 ℃ of dissolving mix homogeneously mutually, add the B phase before Cyclomethicone emulsifying, and during emulsifying, B is added to A mutually and homogenizing 5min, adds C phase homogenizing while being cooled to 50 ℃ 2 minutes, after ageing 24h, packs, and gets final product.
embodiment 5 facial treatment milk
Table 2 provides and contains the facial treatment milk formula with compositions of preservative efficacy of the present invention, and the consumption of each material means with mass fraction.
Table 2
The preparation method of whitening and skin-protecting breast: the dimethyl siloxane in formula table, isopropyl palmitate, Miglyol 812, monoglyceride, stearic acid are mixed, be heated to 80 ℃, fusing stirs, as oil phase; 1,2-PD in formula table, the compositions (II) with preservative efficacy, triethanolamine, deionized water are mixed, be heated to 85 ℃, stirring and dissolving is even, as water.Oil phase and water are added in the emulsifying pot, stir, emulsifying homogeneous, after 6 minutes, stirs while being cooled to 50 ℃, adds essence, stirs, and is cooled to 38 ℃, gets final product.
the preparation of embodiment 6 surfactant
Table 3 provides and contains the surfactant formula with compositions of preservative efficacy of the present invention, and the consumption of each material means with mass fraction.
Table 3
Preparation method: deionized water is heated to 85 ℃, adds hydroxyethyl-cellulose, and stirring and dissolving is even, adds 1,2-PD.When stirring is cooled to 50 ℃, add other compositions, continue stirring and be cooled to 38 ℃, get final product.
the common surfactant of comparative example 1
Table 4 provides the common surfactant formula that does not contain compositions of the present invention, and the consumption of each material means with mass fraction.
Table 4
Preparation method: deionized water is heated to 85 ℃, adds hydroxyethyl-cellulose, and stirring and dissolving is even, adds 1,2-PD.When stirring is cooled to 50 ℃, add other compositions, continue stirring and be cooled to 38 ℃, get final product.
experimental example 1 skin irritation evaluation experimental
Take 40 women and 10 male is object, get in the coyote hole that the 30mg sample is placed in speckle examination adhesive tape, the speckle examination adhesive tape that will be equipped with immediately sample starts vertically to be affixed on from bottom the normal skin of left forearm, and light pressing chamber, to drive away air, and is uniformly distributed trier one by one simultaneously.Labelling is carried out at the test position, in order to observe.Pasted skin once every 24 hours, open half an hour after paster, the term according to CTFA guide (1981) checks.Carried out altogether the experiment of 6 patch, after pasting skin and finishing the 6th day, in order to observe late response, carried out appending inspection.Data are utilized last check result, compare.Identify that take table 5 carries out as standard.Substances is respectively the surfactant of embodiment 6 and the common surfactant of comparative example 1, and result is as shown in table 6.
Table 5
| Grade | Symbol | Standard of perfection |
| 0 | - | Negative reaction: non-stimulated, without erythema |
| 1 | ± | Suspicious reaction: slight erythema |
| 2 | + | Weak positive reaction: erythema |
| 3 | ++ | Strong positive reaction: erythema, pimple, vesicle |
| 4 | +++ | Extremely strong positive reaction: serious edema, bulla |
Table 6
| The lagging number of times | Comparative example 1 | Blank experiment | Embodiment 1 |
| 1 | 1 time ± | 0 | 0 |
| 2 | 1 time+ | 0 | 0 |
| 3 | ? | 0 | 0 |
| 4 | 1 time ± | 0 | 0 |
| 5 | ? | 0 | 0 |
| 6 | ? | 0 | 0 |
| Finish latter the 6th day | 1 time ± | 0 | 0 |
| Add up to | 3 times ±, 1 time+ | 0 | 0 |
By this result of the test, can recognize that blank experiment is non-stimulated, the stimulation of the surfactant of embodiment 6 to skin, and the common surfactant of comparative example 1 still exists the irritant reaction of skin.Illustrate that the cosmetics that adopt the compositions with preservative efficacy of the present invention to prepare are less than the cosmetics zest prepared by common preservatives, safer.
experimental example 2 preservation challenge evaluation experimentals
1, experimental strain
Staphylococcus aureus ATCC 6538(staphylococcus aureus)
Escherichia coli ATCC 8739 (escherichia coli)
Pseudomonas aeruginosa ATCC 9027 (bacillus pyocyaneus)
Candida albicans ATCC 10231 (candida albicans)
Aspergillus niger ATCC 9029 (Aspergillus niger)
2, the keeping of experimental strain and condition of culture
(1) antibacterial and candida albicans
Culture medium: TSB
Maintaining requirement: 4 ~ 8 ℃ of cold preservations
Maintaining requirement: 2 months
(2) Aspergillus niger
Culture medium: PDB
Maintaining requirement: 4 ~ 8 ℃ of cold preservations
Maintaining requirement: 2 months
3, bacterium liquid manufacture method for test
(1) (the every gram of the test portion of experiment is 10 to antibacterial liquid manufacture method
7cfu)
Three kinds of antibacterials and Candida albicans are respectively got 50 μ L and are added in the 5mL of sterilization treatment TSB culture fluid and inoculated, and then at 37 ℃ of shaking tables, cultivate 48 hours, obtain the bacterium liquid of each bacterium.According to 10
6, 10
7, 10
8three dilution factors are cultivated it by the LB culture medium, then confirm the viable count of each bacterium liquid.Each bacterium liquid is got in the 50mL centrifuge tube that 1mL is added to and is mixed, and (concentration of mixed bacteria liquid is for preferably being controlled at 1.0 * 10 to obtain mixed bacteria liquid
9the cfu/mL left and right).
(2) (the every gram of the test portion of experiment is 10 to the manufacture method of fungus liquid
5cfu)
Reference culture bacterium (Aspergillus niger) is inoculated on culture medium, then be placed on after the incubator the inside of 25 ℃ cultivates spore fully, the spore of cultured black is inoculated in culture fluid PDB10mL with the platinum inoculating loop, and fully concussion evenly, then scrapes off spore in the culture medium the inside.After the spore that scrapes off and fluid medium are fully mixed, get top bacterium liquid and collect in centrifuge tube, obtain fungus liquid.By fungus liquid (approximately 10
7cfu), after being diluted in the upper cultivation of PDA, confirm the bacterium number of survival as far as possible.
4, experimental technique
(1) the anticorrosion laboratory method of antibacterial
1. test portion 20g is placed on to sterilizing 50mL centrifuge tube the inside.
2. the every gram 10 of the test portion of the antibacterial liquid of making
9cfu and 200 μ L are inoculated in test portion and mix uniformly.
3. the bacterium liquid mixed is put into to the culture medium the inside of 35 ℃ of room temperature, cultivate 4 time-of-weeks then from the inoculation day 7,14,28 days after, the several explanations according to experimental technique of bacterium of also surviving in test products are tested, and then 10 times of dilutions of stock solution are tested (the 7th day then tested by 100 times of dilutions).
(2) aspergillus niger antiseptical experimental technique
1. by sterilizing the 50ml centrifuge tube be placed in test portion 20g the inside.
2. the every gram 10 of the test portion of the fungus liquid of making
7cfu and 200 μ L are inoculated in test portion and mix uniformly
3. the bacterium liquid mixed is put into to the culture medium the inside of 25 ℃ of room temperature and carried out the cultivation of 60 days, take and be confirmed whether as an interval whether spoiled and surperficial mycelia has generation in 7 days.Then 10 times of dilutions of stock solution are tested (the 7th day time by 100 times of dilutions, then tested)
5, decision method
The antiseptic power of product is estimated with following standard.
(1) in the 7th day 1 * 10
4it is qualified that the words that cfu/g reduces downwards just are judged to be.
(2), if can determine at 14 days, it is qualified in the time of 28 days, than the words that the bacterium number was few in the 7th day, just to be judged to be.
(3) if in 4 weeks, meet the listed situation of table 7 just be judged to be qualified.
Table 7
| The Grade(quality) | Antibacterial | Fungus (perusal, whether spoiled) |
| A | Bacterium number < 1 * 10 after 7 days 4 cfu/g | Within 6 weeks, mycete does not generate |
| B | Bacterium number < 1 * 10 after 7 days 5 cfu/g | Within 4 weeks, mycete does not generate |
6, result
The product that embodiment 4,5,6 is made carries out the preservation challenge experiment, the results are shown in Table shown in 8,9,10.
Table 8
| Embodiment 4 | The blank sample contrast | 0d(once adds bacterium) | 7d | 14d | 21d | 28d |
| Antibacterial | 0 | 3.0×10 7 | 10 | 0 | 0 | 0 |
| Fungus | 0 | 1.0×10 5 | 0 | 0 | 0 | 0 |
Table 9
| Embodiment 5 | The blank sample contrast | 0d(once adds bacterium) | 7d | 14d | 21d | 28d |
| Antibacterial | 0 | 3.0×10 7 | 0 | 0 | 0 | 0 |
| Fungus | 0 | 1.0×10 5 | 0 | 0 | 0 | 0 |
Table 10
| Embodiment 6 | The blank sample contrast | 0d(once adds bacterium) | 7d | 14d | 21d | 28d |
| Antibacterial | 0 | 3.0×10 7 | 10 | 0 | 0 | 0 |
| Fungus | 0 | 1.0×10 5 | 0 | 0 | 0 | 0 |
From table 8,9,10, it is qualified that the product that embodiment 4,5,6 makes is the preservation challenge experimental result, has stronger antiseptic power.
Claims (2)
1. the compositions with preservative efficacy, is characterized in that the component that comprises following percentage by weight: 1,2-ethohexadiol 10-80%, 1,2-hexanediol 10-80%, synergist 1-30%; In compositions, synergist is tropolone, Sensiva SC50,1,2-PD, 1,3 butylene glycol, 1, one or more in the 2-pentanediol; The preparation method of compositions is characterized in that: by 1,2-ethohexadiol, 1,2-hexanediol, synergist mix, and stirring and dissolving is even, gets final product.
2. the application of compositions in preparing cosmetics with preservative efficacy claimed in claim 1, is characterized in that in cosmetics containing the above-mentioned compositions with preservative efficacy, and its consumption is 0.02-5%, and preferable amount is 0.1-2%.
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104586679A (en) * | 2014-12-22 | 2015-05-06 | 广州环亚化妆品科技有限公司 | Preservative-free mask composition and preparation method thereof |
| CN104644499A (en) * | 2015-01-27 | 2015-05-27 | 广州环亚化妆品科技有限公司 | Composition with powerful preservative effect and application of composition in cosmetics |
| CN104800128A (en) * | 2015-05-06 | 2015-07-29 | 广州神采化妆品有限公司 | Preservative-free multi-effect repair essence and preparation method thereof |
| CN107550745A (en) * | 2017-08-31 | 2018-01-09 | 北京明弘科贸有限责任公司 | A kind of anticorrosive composite and its application |
| CN109363962A (en) * | 2018-09-26 | 2019-02-22 | 浙江珂瑞康生物医疗科技有限公司 | A kind of active collagen skin care compositions and preparation method thereof |
| WO2021243669A1 (en) * | 2020-06-05 | 2021-12-09 | Henkel Ag & Co. Kgaa | Use of a compound containing two or more alcoholic hydroxyl groups or phenolic hydroxyl groups as a microbiome regulator on scalp |
| CN116196230A (en) * | 2023-03-10 | 2023-06-02 | 广州艾卓生物科技股份有限公司 | Moxa alcohol composition and application thereof |
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| CN102379821A (en) * | 2010-08-26 | 2012-03-21 | 科丝美诗(中国)化妆品有限公司 | Cosmetic additive and cosmetic |
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102379821A (en) * | 2010-08-26 | 2012-03-21 | 科丝美诗(中国)化妆品有限公司 | Cosmetic additive and cosmetic |
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| CN104586679A (en) * | 2014-12-22 | 2015-05-06 | 广州环亚化妆品科技有限公司 | Preservative-free mask composition and preparation method thereof |
| CN104586679B (en) * | 2014-12-22 | 2018-08-03 | 广州环亚化妆品科技有限公司 | A kind of face paste film composition and preparation method thereof without preservative |
| CN104644499A (en) * | 2015-01-27 | 2015-05-27 | 广州环亚化妆品科技有限公司 | Composition with powerful preservative effect and application of composition in cosmetics |
| CN104800128A (en) * | 2015-05-06 | 2015-07-29 | 广州神采化妆品有限公司 | Preservative-free multi-effect repair essence and preparation method thereof |
| CN104800128B (en) * | 2015-05-06 | 2018-01-23 | 广州神采化妆品有限公司 | A kind of multiple-effect without preservative repairs Essence and preparation method thereof |
| CN107550745A (en) * | 2017-08-31 | 2018-01-09 | 北京明弘科贸有限责任公司 | A kind of anticorrosive composite and its application |
| CN109363962A (en) * | 2018-09-26 | 2019-02-22 | 浙江珂瑞康生物医疗科技有限公司 | A kind of active collagen skin care compositions and preparation method thereof |
| CN109363962B (en) * | 2018-09-26 | 2022-07-26 | 浙江珂瑞康生物医疗科技有限公司 | Active collagen skin care composition and preparation method thereof |
| WO2021243669A1 (en) * | 2020-06-05 | 2021-12-09 | Henkel Ag & Co. Kgaa | Use of a compound containing two or more alcoholic hydroxyl groups or phenolic hydroxyl groups as a microbiome regulator on scalp |
| CN116196230A (en) * | 2023-03-10 | 2023-06-02 | 广州艾卓生物科技股份有限公司 | Moxa alcohol composition and application thereof |
| CN116196230B (en) * | 2023-03-10 | 2023-11-10 | 广州艾卓生物科技股份有限公司 | Corrosion-resistant composition and application thereof |
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