CN112451406B - Plant source multi-effect composition and preparation method and application thereof - Google Patents
Plant source multi-effect composition and preparation method and application thereof Download PDFInfo
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K8/00—Cosmetics or similar toiletry preparations
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
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- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
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Abstract
The invention discloses a plant source multi-effect composition, a preparation method and application thereof, wherein the composition comprises the following components: the botanical bacteriostatic whitening component and the solvent are characterized in that the botanical bacteriostatic whitening component comprises at least three of the following substances: eugenol, coumarin, hydrolyzed procyanidin, benzyl cinnamate; the preparation method of the composition comprises the following steps: mixing the plant source antibacterial whitening component and the solvent, and stirring and dissolving uniformly to obtain the product; the plant source multi-effect composition prepared by the invention has a synergistic effect, can quickly and long-acting inhibit bacteria, inhibit tyrosinase activity, reduce melanin generation and has a whitening effect, and the components of the composition are all pure natural components, so that the composition is safe and non-irritant to human skin.
Description
Technical Field
The invention belongs to the field of cosmetics, and particularly relates to a plant source multi-effect composition, and a preparation method and application thereof.
Background
With the development of society and the improvement of living standard, people put higher demands on the diversification of the functions of cosmetics and the quality of products. The abundant nutrient substances in the cosmetics are easy to cause the growth and the propagation of microorganisms in the products, and the cosmetics are easy to be polluted and further deteriorate due to the contact with the microorganisms in the repeated use process.
The antiseptic can inhibit microorganism growth in cosmetic and prevent product deterioration. According to technical Specification for safety of cosmetics (2015 edition), there are 51 kinds of preservatives for cosmetic preparations at present, including p-hydroxybenzoate esters, phenoxyethanol, isothiazolinone and the like. On one hand, the existing chemical synthetic preservatives still have various potential hazards which cannot be eliminated; on the other hand, consumers have a strong psychological repulsion to chemical additives. To meet the increasing demands of consumers, the development of cosmetics without adding chemical preservatives has become a hot spot.
Disclosure of Invention
In order to solve the defects of the prior art, the invention provides a plant source multi-effect composition, compounds with an antiseptic effect are screened from common cosmetic raw materials and optimized and combined, and finally the plant source multi-effect composition which can quickly and long-term inhibit bacteria, has a whitening effect and is safe and non-irritant to human skin is provided, and the components of the multi-effect composition have an antibacterial synergistic effect.
In order to achieve the purpose of the invention, the invention adopts the following technical scheme:
the plant source multi-effect composition is characterized by comprising plant source bacteriostasis and whitening components and a solvent, wherein the plant source bacteriostasis and whitening components comprise at least three of the following substances: eugenol, coumarin, hydrolyzed procyanidin and benzyl cinnamate.
The botanical antibacterial whitening component comprises the following components in percentage by mass: 0.5-15% of eugenol, 0.5-15% of coumarin, 1-20% of hydrolyzed procyanidine and 1-20% of benzyl cinnamate, wherein the mass percentage is expressed by the weight of each component relative to the total weight of the plant source multi-effect composition.
The botanical antibacterial whitening component comprises the following components in percentage by mass: 0.5-15% of eugenol, 0.5-15% of coumarin and 1-20% of hydrolyzed procyanidin.
The botanical antibacterial whitening component comprises the following components in percentage by mass: 0.5-15% of eugenol, 1-20% of benzyl cinnamate and 1-20% of hydrolyzed procyanidine.
The botanical antibacterial whitening component comprises the following components in percentage by mass: benzyl cinnamate 1-20%, coumarin 0.5-15%, and hydrolyzed procyanidin 1-20%.
The botanical antibacterial whitening component comprises the following components in percentage by mass: 0.5-15% of eugenol, 0.5-15% of coumarin and 1-20% of benzyl cinnamate.
The botanical bacteriostatic whitening component comprises the following components in percentage by mass: 0.5-15% of eugenol, 0.5-15% of coumarin, 1-20% of hydrolyzed procyanidine and 1-20% of benzyl cinnamate.
Preferably, the plant source bacteriostatic whitening component comprises the following components in percentage by mass: 7% of eugenol, 7% of coumarin and 10% of hydrolyzed procyanidin.
Preferably, the plant source bacteriostatic whitening component comprises the following components in percentage by mass: 4% of eugenol, 7% of hydrolyzed procyanidin and 13% of benzyl cinnamate.
Preferably, the plant source bacteriostatic whitening component comprises the following components in percentage by mass: coumarin 4%, hydrolyzed procyanidin 7% and benzyl cinnamate 13%.
Preferably, the plant source bacteriostatic whitening component comprises the following components in percentage by mass: 5% of eugenol, 5% of coumarin and 14% of benzyl cinnamate.
Further preferably, the plant-derived bacteriostatic whitening component comprises the following components in percentage by mass: 3% of eugenol, 3% of coumarin, 6% of hydrolyzed procyanidine and 12% of benzyl cinnamate.
The solvent is selected from one or more than one of 1, 2-propylene glycol, 1, 3-propylene glycol, 1, 2-butylene glycol, 1, 3-butylene glycol, 1, 4-butylene glycol, 1, 2-pentanediol, 1, 5-pentanediol, isoprene glycol, 1, 2-hexanediol, 1, 6-hexanediol, methoxybutanol, ethanol, menthol, ethyl acetate, laurocapram, polyvinylpyrrolidone, water, glycerol, methyl propylene glycol and ethyl hexyl glycerol.
Further, the plant source multi-effect composition is prepared by the following steps: at room temperature, stirring and dissolving the plant source antibacterial whitening component and the solvent, and uniformly mixing.
The invention also aims to apply the plant source multi-effect composition to cosmetics to prepare the cosmetics with quick and long-acting bacteriostasis and good whitening effect.
In order to realize another purpose of the invention, the invention adopts the following technical scheme: the plant source multi-effect composition is used for preparing cosmetics, and is characterized in that the cosmetics contain the plant source multi-effect composition, and the using amount of the plant source multi-effect composition is 0.01-5% by mass percent. The preferred amount is 0.05-1%.
The invention has the beneficial effects that:
each component in the composition is a common component in cosmetics, is a pure natural plant source, is safe and non-irritant, and does not belong to a chemical preservative specified in the cosmetic hygiene Specification (2015). After combination optimization, the components of the plant source multi-effect composition are synergistic, the antibacterial effect is improved, the antibacterial spectrum is broad, the effect is quick, and the antibacterial effect is long-term effective. In addition, the composition has whitening effect, and can inhibit tyrosinase activity and reduce melanin generation and deposition.
The plant source multi-effect composition is added into cosmetics to replace the traditional chemical preservative. The formulation of the cosmetic is not particularly limited, and may be a facial mask solution, a lotion, a cream, a toner, a essence, a stock solution, a face cleanser, a toner, a perfume, a makeup remover, a foundation solution, a foundation cream, a concealer, a rouge, a lipstick, an eye shadow, a blush, or the like. The prepared cosmetic is mild, safe and non-irritant, has a good antiseptic effect, and can effectively prolong the shelf life of the cosmetic.
Detailed Description
The invention is further illustrated by the following examples. These examples are intended to illustrate the invention and are not intended to limit the scope of the invention. Experimental procedures without specific conditions noted in the examples below, generally according to conditions conventional in the art or as suggested by the manufacturer; the raw materials, reagents and the like used are, unless otherwise specified, those commercially available from the conventional markets and the like. Any insubstantial changes and substitutions made by those skilled in the art based on the present invention are intended to be covered by the claims.
In the present invention, the percentages are mass fractions unless otherwise specified.
Example 1 a plant-derived pleiotropic composition (I) and a process for its preparation.
The plant source multi-effect composition (I) comprises the following components in percentage by mass: 7% of eugenol, 7% of coumarin, 10% of hydrolyzed procyanidine and 76% of 1, 3-butanediol. The preparation method comprises the following steps: uniformly stirring 7g of eugenol, 7g of coumarin, 10g of hydrolyzed procyanidin and 76g of 1, 3-butanediol, and mixing and dissolving to obtain the plant source multi-effect composition.
Example 2 a plant-derived pleiotropic composition (II) and a process for its preparation.
The plant source multi-effect composition (II) comprises the following components in percentage by mass: 4% of eugenol, 7% of hydrolyzed procyanidin, 13% of benzyl cinnamate and 76% of 1, 3-butanediol. The preparation method comprises the following steps: 4g of eugenol, 7g of hydrolyzed procyanidine, 13g of benzyl cinnamate and 76g of 1, 3-butanediol are uniformly stirred, mixed and dissolved, and the plant source multi-effect composition can be obtained.
Example 3 plant-derived pleiotropic composition (III) and process for its preparation.
The plant source multi-effect composition (III) comprises the following components in percentage by mass: 4% of coumarin, 7% of hydrolyzed procyanidin, 13% of benzyl cinnamate and 76% of 1, 3-butanediol. The preparation method comprises the following steps: 4g of coumarin, 7g of hydrolyzed procyanidin, 13g of benzyl cinnamate and 76g of 1, 3-butanediol are uniformly stirred, mixed and dissolved, and the plant source multi-effect composition can be obtained.
Example 4 plant-derived pleiotropic composition (IV) and a method for preparing the same.
The plant source multi-effect composition (IV) comprises the following components in percentage by mass: 5% of eugenol, 5% of coumarin, 14% of benzyl cinnamate and 76% of 1, 3-butanediol. The preparation method comprises the following steps: 5g of eugenol, 5g of coumarin, 14g of benzyl cinnamate and 76g of 1, 3-butanediol are uniformly stirred, mixed and dissolved, and the plant source multi-effect composition can be obtained.
Example 5 plant-derived pleiotropic composition (v) and a process for its preparation.
The plant source multi-effect composition (V) comprises the following components in percentage by mass: 3% of eugenol, 3% of coumarin, 6% of hydrolyzed procyanidine, 12% of benzyl cinnamate and 76% of 1, 3-butanediol. The preparation method comprises the following steps: 3g of eugenol, 3g of coumarin, 6g of hydrolyzed procyanidin, 12g of benzyl cinnamate and 76g of 1, 3-butanediol are uniformly stirred, mixed and dissolved, and the botanical multi-effect composition can be obtained.
Comparative example 1
The composition comprises the following components in percentage by mass: 24% of eugenol and 76% of 1, 3-butanediol. The preparation method comprises the following steps: 24g of eugenol and 76g of 1, 3-butanediol are uniformly stirred and mixed and dissolved to obtain the single-component composition.
Comparative example 2
The composition comprises the following components in percentage by mass: 24% of coumarin and 76% of 1, 3-butanediol. The preparation method comprises the following steps: 24g of coumarin and 76g of 1, 3-butanediol are uniformly stirred and mixed and dissolved to obtain the single-component composition.
Comparative example 3
The composition comprises the following components in percentage by mass: 24% of hydrolyzed procyanidin and 76% of 1, 3-butanediol. The preparation method comprises the following steps: 24g of hydrolyzed procyanidin and 76g of 1, 3-butanediol are uniformly stirred and mixed and dissolved to obtain the single-component composition.
Comparative example 4
The composition comprises the following components in percentage by mass: 24% of benzyl cinnamate and 76% of 1, 3-butanediol. The preparation method comprises the following steps: 24g of benzyl cinnamate and 76g of 1, 3-butanediol are uniformly stirred and mixed and dissolved to obtain the single-component composition.
Example 6 determination of Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC).
The experimental method comprises the following steps:
1. and (4) preparing a culture medium.
Weighing 5g of beef extract, 10g of peptone, 10g of glucose and 5g of sodium chloride, adding water, boiling to fully dissolve all the components, and fixing the volume to 1000 mL. After cooling to normal temperature, adjusting the pH value to 7.0-7.8 by using sodium hydroxide with certain concentration.
Sterilizing the culture medium under high pressure steam of 0.1MPa at 121 deg.C for 30min, cooling, and storing in 4 deg.C refrigerator.
2. And (4) preparing a bacterial suspension.
Experimental strains: staphylococcus aureus ATCC6538 from the Guangdong province culture Collection of microorganisms.
Inoculating staphylococcus aureus in logarithmic growth phase in liquid culture medium, and culturing at 37 deg.C for 10 hr. Using sterile liquid culture medium to prepare bacterial liquid into bacterial suspension with 0.5 McLeod turbidity, and diluting according to a ratio of 1:1000 until the bacterial content is about 105CFU/mL。
3. Determination of Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC).
Searching a proper bacteriostatic concentration range by adopting a double dilution method, respectively sucking a certain amount of plant source multi-effect composition (examples 1-5) or single-component composition (comparative examples 1-4) solutions with different concentrations, and respectively adding the plant source multi-effect composition or single-component composition solutions into test tubes containing liquid culture media with the same amount of 0.1% of Tween-80 to ensure that the concentrations of the plant source multi-effect composition or the single-component composition contained in the culture media are as follows: 10. 20, 40, 80, 160, 320, 640 and 1280 mu g/mL, adding 0.05mL of test bacterium liquid into each tube, culturing for 24 hours at 37 ℃ in an incubator, observing the growth condition, and recording the lowest concentration of bacteria-free growth in the test tube to determine the range of proper bacteriostatic concentration.
Subsequently, the Minimum Inhibitory Concentration (MIC) was determined using a gradient method. Respectively sucking a certain amount of plant source multi-effect composition (examples 1-5) or single-component composition (comparative examples 1-4) solutions with different concentrations, respectively adding the plant source multi-effect composition or single-component composition solutions into test tubes containing an equivalent liquid culture medium containing 0.1% of Tween-80 to enable the concentration gradient of the plant source multi-effect composition or the single-component composition to be 10 mu g/mL, then adding 0.05mL of test bacteria liquid into each tube, making 3 parallel groups for each sample to be tested, taking the test tube without adding any bacteria liquid as a blank control, taking 0.1% of Tween 80 and 200 mu g/mL1, taking 3-butanediol as a blank, placing the test tube in an incubator at 37 ℃ for 24h, observing the growth condition, and taking the minimum concentration of bacteria-free growth in the test tube as the Minimum Inhibitory Concentration (MIC) of the test sample. 0.2mL of the sample solution was pipetted from each test tube for sterile growth and evenly spread on a plate medium, and after incubation for 24h at a constant temperature of 37 ℃, the test tubes containing the minimal amount of the plant-derived multi-effect composition or the single-component composition and having sterile growth on the plate were observed, and the corresponding concentration was the Minimal Bactericidal Concentration (MBC) of the corresponding product against the test strain, as shown in Table 1. In the experiment, if the substance concentration of the sample to be detected is 1280 mug/mL, the growth of staphylococcus aureus can not be inhibited, and the antibacterial effect is not considered.
Table 1. results of minimum inhibitory concentration and minimum bactericidal concentration tests.
As can be seen from Table 1, when the single component is used, eugenol, benzyl cinnamate and coumarin all have bacteriostatic effects, but the hydrolyzed procyanidin does not show bacteriostatic effects within the concentration range set by the experiment. When the plant source multi-effect composition is used for acting on staphylococcus aureus, the plant source multi-effect composition shows good antibacterial effect, and the components have antibacterial synergistic effect. In the components, the more the content of benzyl cinnamate, coumarin and eugenol is, the better the antibacterial effect is. Although the hydrolyzed procyanidin has no bacteriostatic effect, the bacteriostatic effect of the composition is not reduced by adding the hydrolyzed procyanidin, and the minimum bacteriostatic concentration and the minimum bactericidal concentration of the hydrolyzed procyanidin are further optimized in a four-component scientific compound optimization scheme while the synergistic bacteriostatic effect is maintained.
Example 7 preservative challenge evaluation experiments.
The experimental method comprises the following steps:
1. experimental strains: the bacteria used in the experiment are mixed bacteria of pseudomonas aeruginosa ATCC9027, escherichia coli ATCC8739 and staphylococcus aureus ATCC 6538; the fungi include Candida albicans ATCC10231 and Aspergillus niger ATCC16404, and are from Guangdong province microorganism culture collection center.
2. Preparation of a sample: the plant-derived multi-effect compositions prepared in examples 1 to 5 and the one-component compositions prepared in comparative examples 1 to 4 (the plant-derived multi-effect compositions prepared in examples 1 to 5 and the one-component compositions prepared in comparative examples 1 to 4 are collectively referred to as compositions) were added to the formulations of table 2, respectively, according to the formulations of table 2, to prepare moisturizing creams as test samples, the formulations of which are shown in table 2.
3. The test method comprises the following steps: referring to CTFA challenge experiment requirements, namely adding a certain amount of mixed microbial suspension into cosmetics, wherein the added mixed microbial suspension amount is as follows: bacterium 3.0X 107CFU/g (CFU/mL) and fungi 1.0X 105CFU/g (CFU/mL), and separating and detecting the mixed sample at a specific time to observe the survival condition of the microorganism.
And (3) judging test results: results at 0 hours (i.e., immediate post inoculation sampling), 7 days, 14 days, 21 days, and 28 days required 99.9% reduction in bacteria and 90% reduction in fungi at day 7; and continuously drops to zero within 28 days to judge the antiseptic effect of the moisturizing cream, and the specific judgment result refers to table 3.
Example 8 preparation of moisturizing cream.
Table 2. moisturizer formula.
| Name (R) | Mass fraction (%) |
| Composition comprising a metal oxide and a metal oxide | 0.5 |
| Stearyl alcohol ether-2 | 2.0 |
| Stearyl alcohol ether-21 | 3.0 |
| Hexadecanol-octadecanol | 5.0 |
| Isopropyl palmitate | 5.0 |
| Squalane | 5.0 |
| Hydrogenated polyisobutenes | 2.0 |
| DC-200/100 | 1.5 |
| Hyaluronic acid | 0.1 |
| Propylene glycol | 5.0 |
| Amino acid humectant (NMF-50) | 2.0 |
| Carbomer 934 | 0.3 |
| Triethanolamine | 0.3 |
| Essence | 0.02 |
| Deionized water | Balance of |
The preparation method comprises the following steps:
1. oil phase: adding stearyl alcohol ether-2, stearyl alcohol ether-21, isopropyl palmitate, squalane, hydrogenated polyisobutene and DC-200/100 into a jacketed dissolving pot, starting steam for heating, and heating to 70 deg.C under continuously stirring to melt or dissolve completely. Adding oil phase into the composition and essence before emulsification;
2. adding deionized water into jacket dissolving pot, adding hexadecanol-octadecanol, propylene glycol, amino acid humectant (NMF-50) and triethanolamine, stirring, heating to 90-100 deg.C, maintaining for 20min for sterilization, and cooling to 70-80 deg.C;
3. hyaluronic acid and carbomer 934 are prepared separately, dissolved in water, and fully stirred at room temperature to enable the hyaluronic acid and carbomer to be uniformly swelled, so that agglomeration is prevented, homogenization can be performed if necessary, and a water phase is added before emulsification. 3 to 5 percent of water is added according to the formula in order to supplement the water volatilized during heating and emulsification;
4. the oil phase and water phase raw materials are added into an emulsifying pot through a filter according to a certain sequence, and are stirred and emulsified for a certain time at the temperature of 70-80 ℃. After emulsification, cooling the emulsification system to be close to room temperature, continuing stirring for about 10min, stopping stirring, cooling, and then checking to be discharged;
5. and sealing the storage barrel after discharging, and moving to a standing room for later use.
Table 3. results of microbial preservation challenge test of moisturizing creams prepared in example 8.
As can be seen from table 3, the moisturizing creams containing the plant-derived multi-effect compositions prepared in examples 1 to 5 all passed the preservation challenge test and had a potent preservative effect. In addition, as shown in the table 3, the moisturizing cream containing the botanical multi-effect composition prepared in the examples 1 to 5 has better preservative effect than the moisturizing cream containing the single-component composition prepared in the comparative examples 1 to 4, and the combination of any three components of eugenol, coumarin, hydrolyzed procyanidin and benzyl cinnamate can improve the preservative effect. The anticorrosive effect of the four substances of eugenol, coumarin, hydrolyzed procyanidin and benzyl cinnamate after scientific compounding is further improved, so that the compounding of any three components of eugenol, coumarin, hydrolyzed procyanidin and benzyl cinnamate and the four substances of eugenol, coumarin, hydrolyzed procyanidin and benzyl cinnamate have a synergistic interaction effect after scientific compounding, the synergistic interaction of the four substances of eugenol, coumarin, hydrolyzed procyanidin and benzyl cinnamate after scientific compounding is optimal, and the anticorrosive capability is improved.
Example 9 preparation of facial mask solution.
TABLE 4 facial mask liquid formulation.
| Name (R) | Mass fraction (%) |
| Composition comprising a metal oxide and a metal oxide | 0.5 |
| 1, 3-propanediol | 5 |
| Chinese gum | 0.1 |
| Sclerotium rolfsii gum | 0.1 |
| Hydroxyethyl cellulose | 0.15 |
| Allantoin | 0.15 |
| Trehalose | 1 |
| Amino acid humectant | 2 |
| Hyaluronic acid sodium salt | 0.1 |
| EG-1 | 2 |
| Collagen powder | 2 |
| Vitamin B3 | 2 |
| K2 | 0.16 |
| Deionized water | Balance of |
The preparation method comprises the following steps:
1. adding 1, 3-propylene glycol, and adding xanthan gum, sclerotium rolfsii gum and hydroxyethyl cellulose into a stirring pot while stirring until the mixture is uniformly stirred and dispersed;
2. continuously stirring the allantoin, the trehalose, the amino acid humectant, the sodium hyaluronate and the EG-1 until the allantoin, the trehalose, the amino acid humectant, the sodium hyaluronate and the EG-1 are uniformly stirred and dispersed;
3. adding 70 parts of deionized water, and then heating to the system temperature of about 85-90 ℃;
4. standing, keeping the temperature for 20min for sterilization, slowly cooling to below 60 deg.C under stirring, adding sufficient deionized water, and adding collagen powder, vitamin B3, and K2 into the system;
5. continuously stirring and cooling to about 40 ℃, adding the composition into the system, continuously stirring for about 10min, stopping stirring, cooling, and then inspecting to discharge materials;
6. and sealing the storage barrel after discharging, and moving to a standing room for later use.
In vitro testing:
1. the purpose of the test is as follows: the tyrosinase inhibition was compared with commercially available whitening agents.
2. Test instruments and reagents.
The main apparatus is as follows: spectrophotometer SpectronicGENESSYS-5, Thermo corporation, USA.
The main reagents are as follows: tyrosinase (sigma, usa), the other reagents being conventional reagents.
3. Test methods.
Phosphate buffered saline PBS (pH 6.8, 0.1mol/L), sample solution, and tyrosine solution were added to each tube. Placing in 37 deg.C water bath for 10min, adding tyrosinase, reacting in 37 deg.C water bath for 10min, measuring absorbance value at 475nm, repeating experiment for 3 times, and averaging.
The experimental system design is shown in table 5, C1 is blank control, C2 is used for blank zeroing, S1 is sample tube, and S2 is used for sample zeroing. The plant-derived multi-effect compositions prepared in examples 1 to 5 and the one-component compositions prepared in comparative examples 1 to 4 (the plant-derived multi-effect compositions prepared in examples 1 to 5 and the one-component compositions prepared in comparative examples 1 to 4 are collectively referred to as compositions) were added to the formulations of table 4, respectively, according to the formulations of table 4, to prepare mask solutions as test samples, and the formulations are shown in table 4.
Tyrosinase inhibition ═ (blank absorbance value-sample absorbance value)/blank absorbance value × 100%
TABLE 5 tyrosinase inhibition experiment system sample application Table.
| Reagent | C1/mL | C2/mL | S1/mL | S2/mL |
| PBS | 2 | 2.5 | 1 | 1.5 |
| Sample (I) | 0 | 0 | 1 | 1 |
| L-tyrosine | 1 | 1 | 1 | 1 |
| Tyrosinase solution | 0.5 | 0 | 0.5 | 0 |
4. The test results are shown in Table 6.
TABLE 6 tyrosinase inhibition assay of the facial mask solutions prepared in example 9.
As can be seen from table 6, the antiseptic effect of the mask solution containing the plant-derived multi-effect composition prepared in examples 1 to 4 is better than the whitening effect of the mask solution containing the single-component composition prepared in comparative examples 1 to 4, which indicates that the whitening effect can be improved by the compounding of any three components, namely eugenol, coumarin, hydrolyzed procyanidin and benzyl cinnamate. The antiseptic effect of the mask liquid of the plant source multi-effect composition prepared in the embodiment 5 is better, which shows that the whitening effect of the cosmetics is further improved by adding four substances of eugenol, coumarin, hydrolyzed procyanidine and benzyl cinnamate into the cosmetics after scientific compounding. Therefore, the compounding of any three components of eugenol, coumarin, hydrolyzed procyanidine and benzyl cinnamate and the scientific compounding of four substances of eugenol, coumarin, hydrolyzed procyanidine and benzyl cinnamate have the whitening synergistic effect, and the whitening synergistic effect of the four substances of eugenol, coumarin, hydrolyzed procyanidine and benzyl cinnamate is the best.
Claims (8)
1. The plant source multi-effect composition consists of plant source bacteriostasis and whitening components and a solvent, and is characterized in that the plant source bacteriostasis and whitening components are selected from at least three of the following substances: eugenol, coumarin, hydrolyzed procyanidin, benzyl cinnamate; the botanical antibacterial whitening component comprises the following components in percentage by mass: 0.5-15% of eugenol, 0.5-15% of coumarin, 1-20% of hydrolyzed procyanidine and 1-20% of benzyl cinnamate, wherein the mass percentage is expressed by the mass of each component relative to the total mass of the plant source multi-effect composition; the solvent is selected from one or more than one of 1, 2-propylene glycol, 1, 3-propylene glycol, 1, 2-butylene glycol, 1, 3-butylene glycol, 1, 4-butylene glycol, 1, 2-pentanediol, 1, 5-pentanediol, isoprene glycol, 1, 2-hexanediol, 1, 6-hexanediol, methoxybutanol, ethanol, menthol, ethyl acetate, laurocapram, polyvinylpyrrolidone, water, glycerol, methyl propylene glycol and ethyl hexyl glycerol.
2. The plant-derived multi-effect composition according to claim 1, wherein the plant-derived bacteriostatic whitening component consists of the following components in percentage by mass: 0.5-15% of eugenol, 0.5-15% of coumarin and 1-20% of hydrolyzed procyanidin.
3. The plant-derived multi-effect composition according to claim 1, wherein the plant-derived bacteriostatic whitening component consists of the following components in percentage by mass: 0.5-15% of eugenol, 1-20% of benzyl cinnamate and 1-20% of hydrolyzed procyanidine.
4. The plant-derived multi-effect composition according to claim 1, wherein the plant-derived bacteriostatic whitening component consists of the following components in percentage by mass: 0.5-15% of coumarin, 1-20% of benzyl cinnamate and 1-20% of hydrolyzed procyanidine.
5. The plant-derived multi-effect composition according to claim 1, wherein the plant-derived bacteriostatic whitening component consists of the following components in percentage by mass: 0.5-15% of eugenol, 0.5-15% of coumarin and 1-20% of benzyl cinnamate.
6. The use of the plant-derived multi-effect composition according to claim 1 for preparing cosmetics, wherein the plant-derived multi-effect composition is contained in the cosmetics in an amount of 0.01 to 5% by mass, and the cosmetics are selected from facial mask liquid, toner, essence, stock solution, facial cleanser, perfume, makeup remover, foundation solution, foundation cream, concealer, rouge, lipstick, eye shadow or blush.
7. The use of the plant-derived multi-effect composition according to claim 1 in the preparation of cosmetics, wherein the plant-derived multi-effect composition is contained in the cosmetics, wherein the plant-derived multi-effect composition is used in an amount of 0.01-5% by mass, and the cosmetics are selected from emulsions, creams or lotions.
8. The method for preparing a plant-derived multi-effect composition according to claim 1, comprising the steps of: stirring and dissolving the plant source antibacterial whitening component and the solvent at room temperature, and uniformly mixing.
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