CN109363962A - A kind of active collagen skin care compositions and preparation method thereof - Google Patents
A kind of active collagen skin care compositions and preparation method thereof Download PDFInfo
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- CN109363962A CN109363962A CN201811122589.7A CN201811122589A CN109363962A CN 109363962 A CN109363962 A CN 109363962A CN 201811122589 A CN201811122589 A CN 201811122589A CN 109363962 A CN109363962 A CN 109363962A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/65—Collagen; Gelatin; Keratin; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4946—Imidazoles or their condensed derivatives, e.g. benzimidazoles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/30—Characterized by the absence of a particular group of ingredients
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/52—Stabilizers
- A61K2800/524—Preservatives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
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- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
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Abstract
The invention discloses a kind of active collagen skin care compositions and preparation method thereof, active collagen skin care compositions ingredients: active collagen 0.4-0.6%；Methylparaben 0.05-0.15%；1,2- pentanediol 0.99-5%；Bis(hydroxymethyl)imidazolidinyl urea 0.1-0.4%；IPBC 0.05-0.1%；Surplus is water；Preparation method, comprising: 1,2- pentanediol, methylparaben, Bis(hydroxymethyl)imidazolidinyl urea and IPBC are mixed and dissolved, antiseptic mixed solution is obtained, it is cooling；Active collagen is dissolved in the water, active collagen solution is obtained；Antiseptic mixed solution is added in active collagen solution, after mixing to obtain the final product；The composition solves the defect that anti-corrosion composition low temperature is precipitated using high concentration active collagen as the single active ingredient in composition, and by the compounding of anti-corrosion composition, and is not required to addition essence and anti-sensitizer.
Description
Technical field
The present invention relates to a kind of active collagen skin care compositions and preparation method thereof, belong to natural skin care composition technology neck
Domain.
Background technique
Active collagen is the critical function substance for constituting animal body, be present in animal body everywhere in organ, and to each
The adjusting of the normal physiological function of organ plays very important effect.In human skin, active collagen is present in entire true
It is intradermal, the shape of skin is caused, to being formed for the skin for covering entire body, protection body, active collagen plays main
Effect.It is studied, the natural activity collagen extracted has good moisturizing to skin, improves dry skin, increases skin bullet
Property, anti-aging and reduce wrinkle, repair the important roles such as impaired skin, but since its extractive technique is immature, yield is few, one
As add in skin-protection product on a small quantity.
Active collagen needs to store the stabilization to keep its structure in 32 DEG C of environment below, in addition if due to activity
Collagen is rich in nutrition, is very easy to cooperating microorganisms.Therefore a safety is established for the active collagen stoste skin care item of high concentration
System is one ring of most important one.For only having other two using the skin-protection product of active collagen as single functional component
Problem: first, the preservative (especially solid kind) of addition has the problem of low temperature is precipitated when saving, once preservative
It is precipitated, not only the quality of product cannot ensure, and preservative is precipitated and will lead to the protective system of product and die down, may be up to not
Basic demand to national legislation to cosmetics.Second, preservative, which is added, may result in active collagen denaturation, triple-helix structure
It destroys, the bioactivity of product disappears, and the effect of anticipation is not achieved.Current grinding about the skin care item of pure active collagen on the market
Study carefully and design is seldom, is all mainly the real industrialization of compounding energy of functional raw material, the active collagen original for being converted into market sale
The skin care item of liquid or Essence are no.Therefore establish that a kind of low temperature is not precipitated, product odour is low, irritation is low, sensitization
Property it is low, while can guarantee that the skin-protection product of the active collagen of active collagen invariance is insoluble one big at present for a long time again
Problem.
Summary of the invention
For overcome the deficiencies in the prior art, the first purpose of this invention is to provide a kind of active collagen skincare composition
Object, the composition is using high concentration active collagen as the single active ingredient in composition, and by the compounding of anti-corrosion composition,
The defect that anti-corrosion composition low temperature is precipitated is solved, and is not required to addition essence and anti-sensitizer.
Second object of the present invention is to provide a kind of preparation method of above-mentioned active collagen skin care compositions.
Realize that the first purpose of this invention can reach by adopting the following technical scheme that: a kind of active collagen skin care group
Object is closed, including following component by mass percentage:
Further, the molecular weight of active collagen is 200-400kDa.
Further, the molecular weight of active collagen is 300kDa.
Further, active collagen skin care compositions further includes propylben 0.01-0.04%.
Further, including following component by mass percentage:
Realize that second object of the present invention can reach by adopting the following technical scheme that: a kind of activity as described above
The preparation method of collagen skin care compositions, comprising:
The preparation step of antiseptic mixed solution: by 1,2- pentanediol, methylparaben, Bis(hydroxymethyl)imidazolidinyl urea and
IPBC is mixed and is dissolved, and obtains antiseptic mixed solution, is cooled to 20 DEG C or less；
The preparation step of active collagen solution: active collagen is dissolved in the water, and obtains active collagen solution；
The preparation step of active collagen skin care compositions: antiseptic mixed solution is added in active collagen solution, after mixing
To obtain the final product.
Further, in the preparation step of antiseptic mixed solution, by 1,2- pentanediol, methylparaben, bis- (methylols)
Imidazolidinyl urea and IPBC are heated under conditions of 30-40 DEG C to be mixed and dissolves.
Further, in the preparation step of antiseptic mixed solution, propylben and 1,2- pentanediol, nipalgin are additionally added
Methyl esters, Bis(hydroxymethyl)imidazolidinyl urea and IPBC are mixed and are dissolved together.
Further, active collagen solution the preparation step of active collagen skin care compositions: is added in antiseptic mixed solution
In, it mixes to transparent.
Further, the active collagen skin care compositions obtained saves under conditions of being placed in 0-20 DEG C.
Formulation Design Principle of the invention is as follows:
In inventive formulation, active collagen has bioactivity because of its complete triple-helix structure, and making it have can
Cutin-softening layer, repairs many effects such as skin corium, moisturizing water lock, anti-aging and anti-wrinkle at activating cell, so that it is dry to solve skin
The skin problem such as dry, aging, wrinkle.It can be seen that the complete triple-helix structure of active collagen keeps it most important using playing
Effect.Under the protective system of active collagen provided by the invention must be premised on not influencing its complete triple-helix structure,
Reach be not precipitated, smell is low, nonirritant with the requirement without sensitization.
Through studying, the Form aldehyde releases body class such as decoyl hydroximic acid, biguanides in routine techniques preservative can release formaldehyde with
Active collagen crosslinks, so that active collagen be made to be denaturalized；Antibacterial peptide in tunning can be such that active collagen becomes
Property, it influences using skin sense；The smell of the classes preservatives such as Phenoxyethanol, ethyl base glycerol and fragrant fresh ketone itself is larger, it is difficult to reach
The low requirement of smell；Certain glycol in polyalcohols are both good moisturizer and sterilization bacteriostat, such as 1,2- penta 2
Alcohol, hexylene glycol and ethohexadiol, but the irritation of hexylene glycol and ethohexadiol is bigger.
The final present invention establishes the anti-corrosion of methylparaben, 1,2- pentanediol, Bis(hydroxymethyl)imidazolidinyl urea and IPBC
System has good bactericidal and bacteriostatic effect to bacterium or with fungi saccharomycete.Methylparaben in protective system is in water
Solubility it is low, by be added 1,2- pentanediol can greatly increase its solubility in water, thus solve anti-corrosion composition analysis
Out the problem of, and maintain the complete triple-helix structure of active collagen and bioactivity, this protective system smell itself is low, nothing
Irritation and no sensitization.
The moisture retention and the excellent moisture retention of active collagen that 1,2- pentanediol has play synergistic effect, moreover it is possible to beat
Open walk promotion active collagen enters skin corium by hair follicle and acts on cell, effectively increases the biological utilisation of active collagen
Degree, the effect of property that increases active collagen.
Compared with prior art, the beneficial effects of the present invention are:
1, composition of the invention is using high concentration active collagen as the single active ingredient in composition, and passes through anti-
The compounding of rotten ingredient solves the defect that anti-corrosion composition low temperature is precipitated, is not required to addition essence and anti-sensitizer；
2, the salubrious non-greasy skin sense effect of active collagen that composition of the invention is fully retained itself, and guarantee to produce
Product active constituent invariance, to guarantee the moisturizing of active collagen, crease-resistant, maintenance skin effect.
Detailed description of the invention
Fig. 1-4 is that test picture is precipitated in embodiment 1-4；
Fig. 5 is that active collagen identifies electrophoretogram；
Specific embodiment
In the following, being described further in conjunction with attached drawing and specific embodiment to the present invention:
A kind of active collagen skin care compositions, including following component by mass percentage:
The molecular weight of active collagen is 300kDa.
Active collagen skin care compositions is prepared by the following method to obtain:
The preparation step of antiseptic mixed solution: by 1,2- pentanediol, methylparaben, propylben, bis- (methylols)
Imidazolidinyl urea and IPBC heated under conditions of 30-40 DEG C mix and dissolve, obtain antiseptic mixed solution, be cooled to 20 DEG C with
Under；
The preparation step of active collagen solution: active collagen is dissolved in the water, and obtains active collagen solution；
The preparation step of active collagen skin care compositions: by antiseptic mixed solution be added active collagen solution in, mix to
After transparent to obtain the final product.
Save step: obtained active collagen skin care compositions saves under conditions of being placed in 0-20 DEG C.
Embodiment 1-4:
The ingredient and mass percent (%) of 1 embodiment 1-4 of table
The molecular weight of active collagen is 300kDa.
The same specific embodiment of preparation method of the active collagen skin care compositions of embodiment 1-4.
1, corrosion-resistanting test is carried out:
1 corrosion-resistanting test condition of embodiment:
Bacterium solution original concentration (pathogenic bacteria): 3.4 × 108CFU/mL
The sample bacteria containing amount being added to inside sample are as follows: 3.4 × 106CFU/mL
Bacterium solution original concentration (mould yeast): 3.9 × 108CFU/mL
The sample bacteria containing amount being added to inside sample are as follows: 3.9 × 106CFU/mL
Sample total plate count (CFU/g): 10CFU/mL
Sample mould yeast is total (CFU/g): < 1CFU/mL
The corrosion-resistanting test data of 2 embodiment 1 of table
2 corrosion-resistanting test condition of embodiment:
Bacterium solution original concentration (pathogenic bacteria): 3.4 × 108CFU/mL
The sample bacteria containing amount being added to inside sample are as follows: 3.4 × 106CFU/mL
Bacterium solution original concentration (mould yeast): 3.9 × 108CFU/mL
The sample bacteria containing amount being added to inside sample are as follows: 3.9 × 106CFU/mL
Sample total plate count (CFU/g): 7CFU/mL
Sample mould yeast is total (CFU/g): < 1CFU/mL
The corrosion-resistanting test data of 3 embodiment 2 of table
3 corrosion-resistanting test condition of embodiment:
Bacterium solution original concentration (pathogenic bacteria): 3.4 × 108CFU/mL
The sample bacteria containing amount being added to inside sample are as follows: 3.4 × 106CFU/mL
Bacterium solution original concentration (mould yeast): 3.9 × 108CFU/mL
The sample bacteria containing amount being added to inside sample are as follows: 3.9 × 106CFU/mL
Sample total plate count (CFU/g): 10CFU/mL
Sample mould yeast is total (CFU/g): < 1CFU/mL
The corrosion-resistanting test data of 4 embodiment 3 of table
4 corrosion-resistanting test condition of embodiment:
Bacterium solution original concentration (pathogenic bacteria): 3.4 × 108CFU/mL
The sample bacteria containing amount being added to inside sample are as follows: 3.4 × 106CFU/mL
Bacterium solution original concentration (mould yeast): 3.9 × 108CFU/mL
The sample bacteria containing amount being added to inside sample are as follows: 3.9 × 106CFU/mL
Sample total plate count (CFU/g): 5CFU/mL
Sample mould yeast is total (CFU/g): < 1CFU/mL
The corrosion-resistanting test data of 5 embodiment 4 of table
2, precipitation test is carried out to embodiment 1-4:
By the active collagen skin care compositions 15mL of embodiment 1-4, implement after being saved 3 months in the environment of being placed in -10 DEG C
Example 1-4 is as shown in Figs 1-4, without Precipitation.
3, the qualification test of active collagen:
The active collagen skin care compositions after saving 3 months in the environment of being placed in -10 DEG C is taken to carry out SDS-PAGE electrophoresis, electricity
Swimming figure is as shown in figure 5, as seen from the figure, four schemes are done in the active collagen skin care compositions after overstability test to be had containing collagen
There is characteristic 3 band, occur two arteries and veins bands between 100-150KD, is 2 chain of 1 chain of α and α of collagen respectively, in 250KD
There is 1 arteries and veins band, is the β chain that two α chain aggregations are formed.The relative molecular mass of the α chain of i.e. every collagen is 100,000, is had
The tropocollagen molecule quality of triple-helix structure is 300,000.Therefore active collagen skin care compositions of the invention, collagen purity therein
Height remains the bioactivity of collagen.
For those skilled in the art, it can make other each according to the above description of the technical scheme and ideas
Kind is corresponding to be changed and deforms, and all these change and deform the protection model that all should belong to the claims in the present invention
Within enclosing.
Claims (10)
1. a kind of active collagen skin care compositions, it is characterised in that including following component by mass percentage:
2. active collagen skin care compositions as described in claim 1, which is characterized in that the molecular weight of the active collagen is
200-400kDa。
3. active collagen skin care compositions as claimed in claim 2, which is characterized in that the molecular weight of the active collagen is
300kDa。
4. active collagen skin care compositions as described in claim 1, which is characterized in that the active collagen skin care compositions is also
Including propylben 0.01-0.04%.
5. active collagen skin care compositions as claimed in claim 4, it is characterised in that below by mass percentage
Ingredient:
6. a kind of preparation method of active collagen skin care compositions as described in claim 1, characterized by comprising:
The preparation step of antiseptic mixed solution: by 1,2- pentanediol, methylparaben, Bis(hydroxymethyl)imidazolidinyl urea and IPBC
It mixes and dissolves, obtain antiseptic mixed solution, be cooled to 20 DEG C or less；
The preparation step of active collagen solution: active collagen is dissolved in the water, and obtains active collagen solution；
The preparation step of active collagen skin care compositions: antiseptic mixed solution is added in active collagen solution, after mixing to obtain the final product.
7. the preparation method of active collagen skin care compositions as claimed in claim 6, it is characterised in that: antiseptic mixed solution
Condition in preparation step, by 1,2- pentanediol, methylparaben, Bis(hydroxymethyl)imidazolidinyl urea and IPBC at 30-40 DEG C
Lower heating is mixed and is dissolved.
8. the preparation method of active collagen skin care compositions as claimed in claim 6, it is characterised in that: antiseptic mixed solution
In preparation step, it is additionally added propylben and 1,2- pentanediol, methylparaben, Bis(hydroxymethyl)imidazolidinyl urea and IPBC
It mixes and dissolves together.
9. the preparation method of active collagen skin care compositions as claimed in claim 6, it is characterised in that: active collagen skin care group
It closes the preparation step of object: antiseptic mixed solution being added in active collagen solution, is mixed to transparent.
10. the preparation method of active collagen skin care compositions as claimed in claim 6, it is characterised in that: obtained activity gel
Former skin care compositions saves under conditions of being placed in 0-20 DEG C.
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| CN201811122589.7A CN109363962B (en) | 2018-09-26 | 2018-09-26 | Active collagen skin care composition and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN114848527A (en) * | 2022-06-02 | 2022-08-05 | 浙江珂瑞康生物医疗科技有限公司 | Collagen composite solution for injection and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN114848527A (en) * | 2022-06-02 | 2022-08-05 | 浙江珂瑞康生物医疗科技有限公司 | Collagen composite solution for injection and preparation method thereof |
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