CN105687061B - Composition with skin repairing function - Google Patents
Composition with skin repairing function Download PDFInfo
- Publication number
- CN105687061B CN105687061B CN201610239261.8A CN201610239261A CN105687061B CN 105687061 B CN105687061 B CN 105687061B CN 201610239261 A CN201610239261 A CN 201610239261A CN 105687061 B CN105687061 B CN 105687061B
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- skin
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- 239000000203 mixture Substances 0.000 title claims abstract description 39
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerol Natural products OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 37
- -1 glycerol glucoside Chemical class 0.000 claims abstract description 34
- 239000000284 extract Substances 0.000 claims abstract description 28
- YDNKGFDKKRUKPY-JHOUSYSJSA-N C16 ceramide Natural products CCCCCCCCCCCCCCCC(=O)N[C@@H](CO)[C@H](O)C=CCCCCCCCCCCCCC YDNKGFDKKRUKPY-JHOUSYSJSA-N 0.000 claims abstract description 17
- CRJGESKKUOMBCT-VQTJNVASSA-N N-acetylsphinganine Chemical compound CCCCCCCCCCCCCCC[C@@H](O)[C@H](CO)NC(C)=O CRJGESKKUOMBCT-VQTJNVASSA-N 0.000 claims abstract description 17
- 239000000654 additive Substances 0.000 claims abstract description 17
- 229940106189 ceramide Drugs 0.000 claims abstract description 17
- ZVEQCJWYRWKARO-UHFFFAOYSA-N ceramide Natural products CCCCCCCCCCCCCCC(O)C(=O)NC(CO)C(O)C=CCCC=C(C)CCCCCCCCC ZVEQCJWYRWKARO-UHFFFAOYSA-N 0.000 claims abstract description 17
- VVGIYYKRAMHVLU-UHFFFAOYSA-N newbouldiamide Natural products CCCCCCCCCCCCCCCCCCCC(O)C(O)C(O)C(CO)NC(=O)CCCCCCCCCCCCCCCCC VVGIYYKRAMHVLU-UHFFFAOYSA-N 0.000 claims abstract description 17
- 241000246044 Sophora flavescens Species 0.000 claims abstract description 15
- 229930182478 glucoside Natural products 0.000 claims abstract description 15
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 claims abstract description 15
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- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 9
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- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims description 9
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- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims description 6
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 claims description 6
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- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims description 3
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical class CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 claims description 3
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- GPLRAVKSCUXZTP-UHFFFAOYSA-N diglycerol Chemical compound OCC(O)COCC(O)CO GPLRAVKSCUXZTP-UHFFFAOYSA-N 0.000 claims description 3
- LQZZUXJYWNFBMV-UHFFFAOYSA-N dodecan-1-ol Chemical compound CCCCCCCCCCCCO LQZZUXJYWNFBMV-UHFFFAOYSA-N 0.000 claims description 3
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- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims description 3
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- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 claims description 3
- HYRLWUFWDYFEES-UHFFFAOYSA-M sodium;2-oxopyrrolidine-1-carboxylate Chemical compound [Na+].[O-]C(=O)N1CCCC1=O HYRLWUFWDYFEES-UHFFFAOYSA-M 0.000 claims description 3
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- 229920002307 Dextran Polymers 0.000 claims 2
- CHHHXKFHOYLYRE-UHFFFAOYSA-M 2,4-Hexadienoic acid, potassium salt (1:1), (2E,4E)- Chemical compound [K+].CC=CC=CC([O-])=O CHHHXKFHOYLYRE-UHFFFAOYSA-M 0.000 claims 1
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- 229960001231 choline Drugs 0.000 claims 1
- OEYIOHPDSNJKLS-UHFFFAOYSA-N choline Chemical compound C[N+](C)(C)CCO OEYIOHPDSNJKLS-UHFFFAOYSA-N 0.000 claims 1
- BEFDCLMNVWHSGT-UHFFFAOYSA-N ethenylcyclopentane Chemical compound C=CC1CCCC1 BEFDCLMNVWHSGT-UHFFFAOYSA-N 0.000 claims 1
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/602—Glycosides, e.g. rutin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/55—Phosphorus compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/68—Sphingolipids, e.g. ceramides, cerebrosides, gangliosides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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Abstract
The invention provides a composition with a skin repairing function, which comprises the following components in percentage by weight: 4.5-16% of functional components, 5-10% of additives and 74-90% of deionized water; the sum of the weight percentages of the components is 100 percent; wherein the functional component comprises the following components, by weight, 1-3% of glycerol glucoside, 0.5-0.8% of phosphoinositide choline salt, 0.5-2% of ceramide, 1-5% of glucan, 0.5-1.5% of scutellaria baicalensis extract, 0.5-1.5% of sophora flavescens extract and 0.5-1.5% of liquorice extract. The composition has good moisturizing effect, can remove speckle, eliminate red swelling, reduce wrinkle, and has no toxicity or irritation.
Description
Technical Field
The invention relates to the technical field of skin care products, and particularly relates to a composition with a skin repairing function.
Background
Modern life rhythm is fast, and people face the pressure in many aspects such as life, work. The skin, which is the largest organ covering the surface of the human body, is directly in contact with the external environment, and is easily stimulated by various factors such as dust, ultraviolet rays, dry wind, and the like, and thus is damaged. Meanwhile, the aging speed of the skin is further accelerated along with the influence of factors such as age increase and poor dietary life habits. In order to maintain a good appearance, consumers pay more and more attention to skin care, and the pursuit of skin care products is higher and higher.
The skin care products on the market are various in types, and have the functions of removing acnes, whitening skin, preventing sunlight, eliminating chloasma and moisturizing. However, many consumers do not have skin care products with specific functions due to certain defects of the skin, and more consumers have a need for skin care products with comprehensive functions, namely skin care products capable of improving the skin integrally. Although there are skin care products with comprehensive functions on the market, the skin care products have poor repairing effect on the skin and cannot meet the requirements of consumers.
Disclosure of Invention
The composition has good moisturizing effect, can relieve discomfort caused by sunburn, remove freckles, eliminate red swelling and reduce wrinkles, and is non-toxic and non-irritant.
The composition with the function of repairing skin provided by the invention comprises the following components in percentage by weight: 4.5-16% of functional components, 5-10% of additives and 74-90% of deionized water; the sum of the weight percentages of the components is 100 percent; wherein the functional component comprises the following components, by weight, 1-3% of glycerol glucoside, 0.5-0.8% of phosphoinositide choline salt, 0.5-2% of ceramide, 1-5% of glucan, 0.5-1.5% of scutellaria baicalensis extract, 0.5-1.5% of sophora flavescens extract and 0.5-1.5% of liquorice extract.
The functional components and additives used in the invention, including glycerol glucoside, phosphoinositide choline salt, ceramide, glucan, scutellaria baicalensis extract, sophora flavescens extract, liquorice extract, emulsifier, thickener, humectant and preservative, are all conventional reagents and can be purchased from the market.
Preferably, the functional component comprises the following components, by weight, 1.5-2.5% of glycerol glucoside, 0.6-0.8% of phosphoinositide choline salt, 0.5-1.5% of ceramide, 2-4% of glucan, 0.5-1% of scutellaria baicalensis extract, 0.5-1% of sophora flavescens extract and 0.5-1% of liquorice extract.
Preferably, the functional component comprises the following components, by weight, 2% of glycerol glucoside, 0.7% of phosphoinositide choline salt, 1% of ceramide, 3% of glucan, 0.5% of scutellaria baicalensis, 0.5% of sophora flavescens and 0.5% of liquorice.
Preferably, the additive comprises the following components, by weight, 1-2% of an emulsifier, 1-2% of a thickener, 3-5% of a humectant and 0.2-1% of a preservative.
Preferably, the emulsifier is one or any combination of natural fatty alcohol, diglycerol, fatty acid ester, alkyl glycoside, glyceryl monostearate and hydrogenated lecithin.
Preferably, the thickening agent is one or any combination of pectin, sodium hyaluronate, hydroxyethyl cellulose, lauryl alcohol, cellulose gum and guar gum.
Preferably, the humectant is one or any combination of ethylene glycol, glycerol, hyaluronic acid, sodium pyrrolidone carboxylate and chitin.
Preferably, the preservative is one or any combination of trisorbic acid, potassium trisorbate, vitamin E and tea tree essential oil.
Preferably, the composition with the function of repairing skin comprises the following components in percentage by weight: 4.5-16% of functional components, 5-10% of additives and 74-90% of deionized water; the sum of the weight percentages of the components is 100 percent;
wherein the functional component comprises the following components, by weight, 1.5-2.5% of glycerol glucoside, 0.6-0.8% of phosphoinositide choline salt, 0.5-1.5% of ceramide, 2-4% of glucan, 0.5-1% of scutellaria baicalensis extract, 0.5-1% of sophora flavescens extract and 0.5-1% of liquorice extract;
the additive comprises the following components, by weight, 1-1.5% of an emulsifier, 1-1.5% of a thickener, 3.5-5% of a humectant and 0.2-0.8% of a preservative.
Preferably, the composition with the function of repairing skin comprises the following components in percentage by weight: 8.2 percent of functional components, 8.5 percent of additives and 83.3 percent of deionized water; the sum of the weight percentages of the components is 100 percent;
wherein the functional component comprises the following components, by weight, 2% of glycerol glucoside, 0.7% of phosphoinositide choline salt, 1% of ceramide, 3% of glucan, 0.5% of scutellaria baicalensis extract, 0.5% of sophora flavescens extract and 0.5% of liquorice extract;
the additive comprises the following components, by weight, 1.5% of an emulsifier, 1.5% of a thickener, 5% of a humectant and 0.5% of a preservative.
Preferably, the composition with the function of repairing skin further comprises EDTA-2Na, and the weight percentage of the EDTA-2Na is 0.05% -0.3%.
The technical scheme provided by the invention can have the following beneficial effects:
(1) the composition with the function of repairing skin provided by the invention can activate surface cells of human skin, resist wrinkle and oxidation, delay aging, resist bacteria and diminish inflammation, has very excellent moisturizing and moistening effects, is non-toxic and non-irritant, is green and safe, and has good stability and compatibility.
(2) The functional components of the composition with the function of repairing skin provided by the invention comprise glycerol glucoside, wherein the glycerol glucoside is derived from south Africa Fenghuang grass (immortal grass), and can increase the moisture factor Caspase-14, so that the mass production of NIF natural moisture factors is promoted, a natural skin water ring system is formed, a skin moisture channel is opened from inside to outside, the moisture degree of the skin is increased, the skin is helped to get rid of dryness and calm the skin, and the skin is moist, tender, smooth and elastic.
(3) The functional component of the composition with the function of repairing skin provided by the invention comprises phosphoinositide choline salt (GPI), wherein the GPI is an innovative active component obtained from sunflower lecithin and is a natural component for cell lipid metabolism. GPI can inhibit intracellular phospholipase A2(cpLA2), and cpLA2 is a key enzyme of inflammatory reaction, i.e., GPI can act on the source of inflammatory cascade reaction, completely conforms to the physiological self-regulation system of an organism, and does not interfere the hormone balance of the organism. In addition, GPI inhibits UVB-induced secretion of prostaglandin PGE2 in epidermal keratinocytes and is effective in alleviating UVB-induced erythema.
(4) The composition with the function of repairing skin provided by the invention comprises the functional components of ceramide, the ceramide is the most important lipoid layer in the skin, and if the content of the ceramide is reduced, skin diseases can be caused, so that the moisture of the skin is lost, the elasticity of the skin is lost, wrinkles are easy to generate, even bad flora of the skin is increased, and the skin generates peculiar smell and acne. Ceramide can make skin exert better barrier function, increase skin water-holding capacity, and improve skin dryness, desquamation, roughness, etc.; enhancing skin elasticity, reducing wrinkle, and delaying skin aging; it has effects in relieving atopic dermatitis, alleviating erythema and pruritus, and improving skin.
(5) The functional components of the composition with the function of repairing skin provided by the invention comprise glucan, and the glucan is derived from schizophyllum commune, is natural and harmless, and is an excellent moisturizing agent, an anti-allergy agent and a wrinkle removing agent. The glucan can improve the immunocompetence of skin cells, prevent histamine release, and resist inflammation and allergy; supplementing mucopolysaccharide content in skin cells, removing wrinkles, and delaying aging; improving the moisture content of the stratum corneum of the skin, keeping moisture for a long time and improving the skin glossiness; prevent the skin from being damaged after the sun shines, and accelerate the repair and renewal of the skin after the sun shines.
(6) The functional components of the composition with the function of repairing skin provided by the invention comprise a scutellaria baicalensis extract, a sophora flavescens extract and a liquorice extract. The scutellaria baicalensis extract contains various bioactive flavones, and can prevent hyaluronidase from releasing, so that the scutellaria baicalensis extract has good analgesic effect and anti-allergy and anti-inflammation effects. The sophora flavescens extract contains various alkaloids with medicinal effects, mainly comprises D-matrine and D-oxymatrine, has extremely strong anti-inflammatory and anti-allergy effects, can reduce the release of allergic mediators, is an excellent immunosuppressant, and has a very good relieving effect on skin pruritus symptoms. The licorice extract has the effects of detoxifying, diminishing inflammation and resisting allergy, the effective component of the licorice extract is glycyrrhizic acid, the glycyrrhizic acid is decomposed into glycyrrhetinic acid and glucuronic acid in cells after being absorbed by a human body, the glycyrrhetinic acid has strong antiphlogistic activity, and the glucuronic acid has strong detoxifying effect. The composition prepared from the scutellaria baicalensis extract, the sophora flavescens extract and the liquorice extract contains a large amount of bioactive polysaccharides, and the macromolecular active polysaccharides can form a breathable elastic biological film on the surface of skin, so that the composition has a slow release effect; meanwhile, the elastic biological membrane isolates external bad irritants, so that the skin is prevented from being directly stimulated.
Detailed Description
The invention will be further described with reference to specific embodiments:
the composition with the function of repairing skin comprises the following components in percentage by weight: 4.5-16% of functional components, 5-10% of additives and 74-90% of deionized water; the sum of the weight percentages of the components is 100 percent;
wherein the functional component comprises the following components, by weight, 1-3% of glycerol glucoside, 0.5-0.8% of phosphoinositide choline salt, 0.5-2% of ceramide, 1-5% of glucan, 0.5-1.5% of scutellaria baicalensis extract, 0.5-1.5% of sophora flavescens extract and 0.5-1.5% of liquorice extract;
the additive comprises the following components, by weight, 1-2% of an emulsifier, 1-2% of a thickener, 3-5% of a humectant and 0.2-1% of a preservative;
the emulsifier is one or any combination of natural fatty alcohol, diglycerol, fatty acid ester, alkyl glycoside, glyceryl monostearate and hydrogenated lecithin; the thickening agent is one or any combination of pectin, sodium hyaluronate, hydroxyethyl cellulose, lauryl alcohol, cellulose gum and guar gum; the humectant is one or any combination of ethylene glycol, glycerol, hyaluronic acid, sodium pyrrolidone carboxylate and chitin; the preservative is one or any combination of trisorbic acid, potassium trisorbate, vitamin E and tea tree essential oil.
According to the above technical scheme, 3 specific examples were obtained, and the specific components of the compositions of examples 1-3 are detailed in table 1. The functional ingredients and additives used in examples 1-3 were all commercially available.
Table 1 ingredient table of compositions of examples 1-3
The compositions of examples 1 to 3 having the skin-repairing function were obtained by separately obtaining the components of examples 1 to 3 according to Table 1, and mixing and homogenizing the components, respectively.
In order to verify that the compositions of examples 1 to 3 have the function of repairing skin, a certain brand of skin repair liquid on the market is taken as a control example, the skin repair function of the compositions of examples 1 to 3 and the skin repair liquid of the control example is tested respectively, and evaluation is carried out on 3 indexes of moisturizing, freckle removing and redness eliminating.
(1) Moisturizing effect
The using population: selecting 40 18-28 years old women, and randomly dividing into four groups; 40 women of 28-38 years old were selected and randomized into four groups.
The using method comprises the following steps: after the using population cleans the face in the morning and evening every day, the skin care products of the examples and the comparative examples are smeared, and the effect is counted after the using population uses the skin care products for 15 days.
Evaluation of the effects: after the skin care product is used for 15 days, if the facial skin becomes moist, fine and elastic compared with the facial skin before use, the dry skin on the face disappears, and the moisturizing effect is obvious; on the contrary, the effect is not obvious. The statistical results are shown in Table 2.
TABLE 2 tables of the moisturizing effect of the skin-repairing liquids of examples 1 to 3 and comparative examples
As can be seen from the data in Table 2, according to the feedback of the population aged 18-28 years, the numbers of persons with significant moisturizing effects of the compositions obtained in examples 1-3 were considered to be 8 persons, 7 persons and 8 persons, and the significant rate of the effects was over 70%; the number of people with obvious moisturizing effect of the skin repair liquid in the comparative example is only 5, and the obvious effect rate is only 50%. According to the feedback of people who are 28-38 years old, the numbers of people with obvious moisturizing effect of the composition obtained in the examples 1-3 are respectively 9, 7 and 7, and the obvious effect rate is over 70 percent; the number of people with obvious moisturizing effect of the skin repair liquid in the comparative example is only 4, and the obvious effect rate is only 40%. In conclusion, the compositions with the skin repairing function provided by the embodiments 1 to 3 of the invention have obvious moisturizing effect, and can make the skin moist, fine and elastic after being used, and dry skin on the face disappears.
(2) Speckle removing effect
The using population: 80 female chloasma patients of 30-40 years old are selected, the face of the patient has clear and large plaques which mostly occur in cheek parts, nose parts and cheek bone parts, and the plaques are dark brown, gray brown or black brown. 80 patients were randomly divided into 4 groups, and 20 persons were averaged per group, and the skin care products of examples 1-3 and control were used, respectively.
The using method comprises the following steps: after the using population cleans the face in the morning and evening every day, the skin care products of the embodiment and the control example are smeared, and the effect is counted after the using population uses the skin care products for 30 days.
Evaluation of the effects: referring to the clinical diagnosis and curative effect standard of chloasma formulated by the pigment pathology group of the skin disease professional committee of the Chinese medical society of western and Chinese medicine, the curative effect is divided into 4 grades of basic cure, obvious effect, improvement and ineffectiveness according to the reduction degree of the area of the color spot and the color change.
Basically curing: the reduction of the area of the color spot is more than 90 percent through naked eye observation, and the color basically disappears;
the effect is shown: the area of the color spot is reduced by more than 60% through naked eye observation, and the color is obviously lightened;
improvement: the area of the color spot is reduced by more than 30% through naked eye observation, and the color becomes light;
and (4) invalidation: the area reduction of the color spot is less than 30% by visual observation, and the color change is not obvious.
The statistical results are shown in Table 3.
TABLE 3 speckle-removing Effect of the compositions of examples 1 to 3 and the skin-repairing liquids of the comparative examples
| Basic cure | Show effect | Improvement of life | Invalidation | |
| Example 1 | 8 | 7 | 3 | 2 |
| Example 2 | 6 | 8 | 4 | 2 |
| Example 3 | 5 | 8 | 4 | 3 |
| Comparative example | 2 | 3 | 10 | 5 |
From the data in table 3, the composition obtained in examples 1-3 can be used by chloasma patients, the number of the basic cure persons is 8, 6 and 5, and the cure rate is over 25%; the number of effective people is 7, 8 and 8 respectively. The skin repair liquid of the control example is used by chloasma patients, the number of basic cure people is only 2, the cure rate is only 10%, and the number of significant people is only 3. In conclusion, the composition with the function of repairing skin provided by the embodiments 1 to 3 of the invention has obvious freckle removing effect, and the effect of reducing the freckles of chloasma patients after use is obvious, and the effect is better than that of the skin repairing liquid of the comparative example.
(3) Eliminating skin allergic red swelling
The using population: 80 women with skin allergy and red swelling of 18-28 years old were selected and randomly divided into 4 groups, and 20 persons were averaged in each group, and the skin care products of examples 1-3 and the control example were used, respectively.
The using method comprises the following steps: after the face is cleaned in the morning and evening, the skin care products of the examples and the control examples are smeared, and other skin care products are not smeared. The effect was counted after 15 days of use.
Evaluation of the effects: after the skin care product is used for 15 days, if the redness and swelling disappear, the phenomenon of skin desquamation is reduced, the skin is in a moist state, and the effect of eliminating the skin allergic redness and swelling is obvious; on the contrary, the effect is not obvious. The statistical results are shown in Table 4.
TABLE 4 Table of the effect of eliminating redness of skin-repairing liquid of compositions 1 to 3 and comparative examples
| The effect is obvious | The effect is not obvious | |
| Example 1 | 15 | 5 |
| Example 2 | 17 | 3 |
| Example 3 | 16 | 4 |
| Comparative example | 10 | 10 |
As can be seen from the data in table 4, the compositions obtained in examples 1-3 were effective in eliminating skin allergic red swelling with significant rates of 75%, 85% and 80%, respectively, whereas the skin-repairing solutions of the comparative examples had an effective rate of eliminating skin allergic red swelling of only 50%. Namely, the composition with skin repairing function provided in examples 1 to 3 of the present invention can effectively eliminate redness and swelling, reduce skin desquamation phenomenon and restore the moisturized state.
Various other modifications and changes may be made by those skilled in the art based on the above-described technical solutions and concepts, and all such modifications and changes should fall within the scope of the claims of the present invention.
Claims (5)
1. The composition with the function of repairing skin is characterized by comprising the following components in percentage by weight: 4.5-16% of functional components, 5-10% of additives and 74-90% of deionized water; the sum of the weight percentages of the components is 100 percent;
wherein the functional component comprises the following components, by weight, 1-3% of glycerol glucoside, 0.5-0.8% of phosphoinositide choline salt, 0.5-2% of ceramide, 1-5% of glucan, 0.5-1.5% of scutellaria baicalensis extract, 0.5-1.5% of sophora flavescens extract and 0.5-1.5% of liquorice extract;
the additive comprises the following components, by weight, 1-2% of an emulsifier, 1-2% of a thickener, 3-5% of a humectant and 0.2-1% of a preservative; wherein,
the emulsifier is one or any combination of natural fatty alcohol, diglycerol, fatty acid ester, alkyl glycoside, glyceryl monostearate and hydrogenated lecithin;
the thickening agent is one or any combination of pectin, sodium hyaluronate, hydroxyethyl cellulose, lauryl alcohol, cellulose gum and guar gum;
the humectant is one or any combination of ethylene glycol, glycerol, hyaluronic acid, sodium pyrrolidone carboxylate and chitin;
the preservative is one or any combination of sorbic acid, potassium sorbate, vitamin E and tea tree essential oil.
2. The composition for skin repair according to claim 1, wherein the functional ingredient comprises glycerol glucoside 1.5-2.5 wt%, phosphoinositide choline 0.6-0.8 wt%, ceramide 0.5-1.5 wt%, dextran 2-4 wt%, Scutellariae radix extract 0.5-1 wt%, Sophorae radix extract 0.5-1 wt%, and Glycyrrhizae radix extract 0.5-1 wt%.
3. The composition with skin repairing function according to claim 1, wherein said functional ingredient comprises, in weight percent of said composition, 2% of glyceryl glucoside, 0.7% of phosphoinositide choline salt, 1% of ceramide, 3% of dextran, 0.5% of Scutellaria baicalensis, 0.5% of Sophora flavescens and 0.5% of Glycyrrhiza uralensis.
4. The composition with the skin repairing function of claim 1, which is characterized by comprising the following components in percentage by weight: 4.5-16% of functional components, 5-10% of additives and 74-90% of deionized water; the sum of the weight percentages of the components is 100 percent;
wherein the functional component comprises the following components, by weight, 1.5-2.5% of glycerol glucoside, 0.6-0.8% of phosphoinositide choline salt, 0.5-1.5% of ceramide, 2-4% of glucan, 0.5-1% of scutellaria baicalensis extract, 0.5-1% of sophora flavescens extract and 0.5-1% of liquorice extract;
the additive comprises the following components, by weight, 1-1.5% of an emulsifier, 1-1.5% of a thickener, 3.5-5% of a humectant and 0.2-0.8% of a preservative.
5. The composition with the skin repairing function of claim 1, which is characterized by comprising the following components in percentage by weight: 8.2 percent of functional components, 8.5 percent of additives and 83.3 percent of deionized water; the sum of the weight percentages of the components is 100 percent;
wherein the functional component comprises the following components, by weight, 2% of glycerol glucoside, 0.7% of phosphoinositide choline salt, 1% of ceramide, 3% of glucan, 0.5% of scutellaria baicalensis extract, 0.5% of sophora flavescens extract and 0.5% of liquorice extract;
the additive comprises the following components, by weight, 1.5% of an emulsifier, 1.5% of a thickener, 5% of a humectant and 0.5% of a preservative.
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| CN110859775A (en) * | 2019-12-03 | 2020-03-06 | 中国科学院青岛生物能源与过程研究所 | Application of glycerol glucoside in transdermal absorption composition |
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| CN115887270A (en) * | 2022-04-06 | 2023-04-04 | 青岛中科蓝智生物科技发展有限公司 | Application of glucoside compound |
| CN115887269A (en) * | 2022-04-06 | 2023-04-04 | 青岛中科蓝智生物科技发展有限公司 | Skin care composition containing glucoside compounds and application thereof |
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| CN115887333A (en) * | 2022-07-11 | 2023-04-04 | 青岛中科蓝智生物科技发展有限公司 | Soothing, repairing and moisturizing skin care composition containing glycerol glucoside and application of soothing, repairing and moisturizing skin care composition |
| CN115105423B (en) * | 2022-07-18 | 2023-12-22 | 深圳浦瑞健康科技有限公司 | Composition with anti-inflammatory and anti-allergic activities and application thereof |
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