CN105687061A - Composition with skin repairing function - Google Patents

Abstract

The invention provides a composition with a skin repairing function, which comprises the following components in percentage by weight: 4.5-16% of functional components, 5-10% of additives and 74-90% of deionized water; the sum of the weight percentages of the components is 100 percent; wherein the functional component comprises the following components, by weight, 1-3% of glycerol glucoside, 0.5-0.8% of phosphoinositide choline salt, 0.5-2% of ceramide, 1-5% of glucan, 0.5-1.5% of scutellaria baicalensis extract, 0.5-1.5% of sophora flavescens extract and 0.5-1.5% of liquorice extract. The composition has good moisturizing effect, can remove speckle, eliminate red swelling, reduce wrinkle, and has no toxicity or irritation.

Description

A kind of have the compositions repairing skin function

Technical field

The present invention relates to technical field of skin care, be specifically related to a kind of compositions having and repairing skin function。

Background technology

Modern life rhythm is fast, and people are faced with many-sided pressure such as life, work。The organ that skin is maximum as covering human body surface, directly contacts with external environment, it is easy to is subject to the stimulation of the factor in many ways such as dust, ultraviolet, dry wind, and therefore suffers from damage。Meanwhile, with age, the impact of the factor such as dietary life habits is bad, the aging speed of skin further speeds up。In order to keep good looks, consumers in general increasingly pay attention to the maintenance of skin, and the pursuit of skin care item is also more and more higher。

Skin-protection product type on the market is varied, have anti-acne, whitening, sun-proof, eliminate chloasma, replenishing water and preserving moisture。But, a lot of consumers are not that skin, it is desirable that a kind of skin care item with comprehensive function, can be made the skin care item that entirety is improved by more consumer because skin occurs that the defect of certain aspect needs the skin care item of specific function。Although also there being the skin care item of comprehensive function on the market, but, these skin care item are poor to the repair of skin, do not reach the requirement of consumer。

Summary of the invention

The present invention provides a kind of compositions having and repairing skin function in order to avoid the deficiencies in the prior art part, said composition mend wet effective, can releive shine after the discomfort that causes, speckle dispelling eliminate red and swollen, reduce wrinkle, nontoxic non-stimulated。

According to a kind of compositions with reparation skin function provided by the present invention, including following component by weight percentage: functional components 4.5-16%, additive 5-10% and deionized water 74-90%；The percentage by weight sum of mentioned component is 100%；Wherein, described functional components includes by described composition weight percentages following component: glycosylglycerol 1-3%, phosphoinositide choline salt 0.5-0.8%, ceramide 0.5-2%, glucosan 1-5%, Radix Scutellariae extract 0.5-1.5%, Radix Sophorae Flavescentis extract 0.5-1.5%, Radix Glycyrrhizae extract 0.5-1.5%。

Functional components used in the present invention and additive, it is the reagent of routine including glycosylglycerol, phosphoinositide choline salt, ceramide, glucosan, Radix Scutellariae extract, Radix Sophorae Flavescentis extract, Radix Glycyrrhizae extract, emulsifying agent, thickening agent, wetting agent and preservative, all can obtain from purchase on the market。

Preferably, described functional components includes by described composition weight percentages following component: glycosylglycerol 1.5-2.5%, phosphoinositide choline salt 0.6-0.8%, ceramide 0.5-1.5%, glucosan 2-4%, Radix Scutellariae extract 0.5-1%, Radix Sophorae Flavescentis extract 0.5-1%, Radix Glycyrrhizae extract 0.5-1%。

Preferably, described functional components includes by described composition weight percentages following component: glycosylglycerol 2%, phosphoinositide choline salt 0.7%, Cer EOS %, glucosan 3%, Radix Scutellariae 0.5%, Radix Sophorae Flavescentis 0.5%, Radix Glycyrrhizae 0.5%。

Preferably, described additive includes by described composition weight percentages following component: emulsifying agent 1-2%, thickening agent 1-2%, wetting agent 3-5%, preservative 0.2-1%。

Preferably, described emulsifying agent is the one of which in natural fatty alcohol, two polyglycereol, fatty acid ester, alkyl polyglucoside, glyceryl monostearate and hydrolecithin or combination in any。

Preferably, described thickening agent is the one of which in pectin, hyaluronate sodium, hydroxyethyl cellulose, lauryl alcohol, cellulose gum, guar gum or combination in any。

Preferably, described wetting agent is the one of which in ethylene glycol, glycerol, hyaluronic acid, pyrrolidone sodium carboxylate and chitin or combination in any。

Preferably, described preservative is the one of which in three pears acid, three potassium sorbates, vitamin E and tea tree ethereal oil or combination in any。

Preferably, described in have repair skin function compositions, including following component by weight percentage: functional components 4.5-16%, additive 5-10% and deionized water 74-90%；The percentage by weight sum of mentioned component is 100%；

Wherein, described functional components includes by described composition weight percentages following component: glycosylglycerol 1.5-2.5%, phosphoinositide choline salt 0.6-0.8%, ceramide 0.5-1.5%, glucosan 2-4%, Radix Scutellariae extract 0.5-1%, Radix Sophorae Flavescentis extract 0.5-1%, Radix Glycyrrhizae extract 0.5-1%；

Described additive includes by described composition weight percentages following component: emulsifying agent 1-1.5%, thickening agent 1-1.5%, wetting agent 3.5-5%, preservative 0.2-0.8%。

Preferably, described in have repair skin function compositions, including following component by weight percentage: functional components 8.2%, additive 8.5% and deionized water 83.3%；The percentage by weight sum of mentioned component is 100%；

Wherein, described functional components includes by described composition weight percentages following component: glycosylglycerol 2%, phosphoinositide choline salt 0.7%, Cer EOS %, glucosan 3%, Radix Scutellariae extract 0.5%, Radix Sophorae Flavescentis extract 0.5%, Radix Glycyrrhizae extract 0.5%；

Described additive includes by described composition weight percentages following component: emulsifying agent 1.5%, thickening agent 1.5%, wetting agent 5%, preservative 0.5%。

Preferably, described in have repair skin function compositions also include EDTA-2Na, the percentage by weight of described EDTA-2Na is 0.05%-0.3%。

Technical scheme provided by the present invention can include following beneficial effect:

(1) provided by the present invention have the compositions repairing skin function, energy activating human body skin surface cell, crease-resistant antioxidation, slow down aging, anti-inflammation, have very excellent moisturizing effect, nontoxic non-stimulated, green safety, and there is good stability and compatibility。

(2) provided by the present invention have the compositions repairing skin function, functional components includes glycosylglycerol, glycosylglycerol comes from South Africa FENGHUACAO (Radix Ophiopogonis), it can increase sharply water profit factor Caspase-14, thus promoting that NIF nature moisturizing factor produces in a large number, form skin natural water member ring systems, open skin moisturizing passage from inside to outside, increase skin and moisten degree, help skin to break away from dry, calm skin, makes skin water moisten high resilience tender, smooth。

(3) provided by the present invention have the compositions repairing skin function, and functional components includes phosphoinositide choline salt (GPI), and GPI is the one innovation active component obtained from sunflower lecithin, is the natural component of cytolipin metabolism。GPI can suppress cytosolic phospholipase A2 (cpLA2), and cpLA2 is the key enzyme of inflammatory reaction, and namely GPI can act on the source of cascade of response of inflammation, complies fully with the physiology self-adjusting system of body, without interference with the hormonal balance of body。Additionally, GPI can suppress the secretion of the Prostaglandin PGE2 caused in epidermal keratinocytes by UVB, and can effectively alleviate the erythema caused by UVB。

(4) provided by the present invention have the compositions repairing skin function, functional components includes ceramide, ceramide is most important class lipid layer in skin, if ceramide content declines, dermatosis can be caused, cause that moisture of skin is lost, skin is followed the string, easily produce wrinkle, even can increase the bad flora of skin, make skin produce abnormal flavour, long acne。Ceramide can make skin play better barrier function, increases skin moisture holding capacity, improves xerosis cutis, desquamation, the situation such as coarse；Strengthen skin elasticity, reduce wrinkle, delay skin aging；Atopic dermatitis can be alleviated, relax erythema, pruritus, skin can be improved。

(5) provided by the present invention have the compositions repairing skin function, and functional components includes glucosan, and glucosan derives from Schizophyllum commune Franch．, natural harmless, is the wetting agent of brilliance, anti-sensitizer and wrinkle removal agent。Glucosan can improve Skin Cell immunocompetence, stops histamine release, anti-inflammatory, antiallergic；Supplement glycosaminoglycan content in Skin Cell, wrinkle reduction, slow down aging；Improve keratodermatitis water content, long-acting moisturizing, improve the moist degree of skin；After preventing solarization, skin damages, and accelerates reparation and the renewal of skin after shining。

(6) provided by the present invention have the compositions repairing skin function, and functional components includes Radix Scutellariae extract, Radix Sophorae Flavescentis extract and Radix Glycyrrhizae extract。Containing multiple biological activity flavone in Radix Scutellariae extract, hyaluronic acid enzyme r e lease can be stoped, thus there is good analgesic activity and antiallergic antiinflammation。Containing the multiple alkaloid with medicinal efficacy in Radix Sophorae Flavescentis extract, mainly becoming D-matrine and D-oxymatrine, it has extremely strong antiinflammatory antiallergic effect, it is possible to decrease the release of Anaphylactic mediator, for fabulous immunosuppressant, skin pruritus symptom there is good mitigation。Radix Glycyrrhizae extract has removing toxic substances, antiinflammatory antiallergic effect, and its effective ingredient is glycyrrhizic acid, and glycyrrhizic acid is decomposed into enoxolone and glucuronic acid after being absorbed by the body in cell, and enoxolone has very strong antiphlogistic activity, and glucuronic acid has very strong Detoxication。The compositions made with Radix Scutellariae extract, Radix Sophorae Flavescentis extract and Radix Glycyrrhizae extract contains large number of biological active polysaccharide, and these Large molecule active polysaccharide can form ventilative elastic biological film in skin surface, makes compositions play and has slow release effect；The pessimal stimulation thing that elastic biological film isolation simultaneously is extraneous, it is to avoid skin is subject to direct stimulation。

Detailed description of the invention

Below, in conjunction with detailed description of the invention, the present invention is described further:

A kind of have the compositions repairing skin function, including following component by weight percentage: functional components 4.5-16%, additive 5-10% and deionized water 74-90%；The percentage by weight sum of mentioned component is 100%；

Wherein, described functional components includes by described composition weight percentages following component: glycosylglycerol 1-3%, phosphoinositide choline salt 0.5-0.8%, ceramide 0.5-2%, glucosan 1-5%, Radix Scutellariae extract 0.5-1.5%, Radix Sophorae Flavescentis extract 0.5-1.5%, Radix Glycyrrhizae extract 0.5-1.5%；

Described additive includes by described composition weight percentages following component: emulsifying agent 1-2%, thickening agent 1-2%, wetting agent 3-5%, preservative 0.2-1%；

And described emulsifying agent is the one of which in natural fatty alcohol, two polyglycereol, fatty acid ester, alkyl polyglucoside, glyceryl monostearate and hydrolecithin or combination in any；Described thickening agent is the one of which in pectin, hyaluronate sodium, hydroxyethyl cellulose, lauryl alcohol, cellulose gum, guar gum or combination in any；Described wetting agent is the one of which in ethylene glycol, glycerol, hyaluronic acid, pyrrolidone sodium carboxylate and chitin or combination in any；Described preservative is the one of which in three pears acid, three potassium sorbates, vitamin E and tea tree ethereal oil or combination in any。

According to technique scheme, obtaining 3 specific embodiments, the concrete composition of embodiment 1-3 compositions refers to table 1。Functional components and additive that embodiment 1-3 uses all can obtain from purchase on the market。

The component list of table 1 embodiment 1-3 compositions

According to table 1, obtain each component of embodiment 1-3 respectively, and carry out respectively mixing and homogenizing, namely obtain embodiment 1-3 and there is the compositions repairing skin function。

Compositions in order to verify embodiment 1-3 has reparation skin function, take on the market certain brand skin repair liquid as comparative examples, the skin repair liquid of testing example 1-3 compositions and the comparative examples repair function to skin respectively, passes judgment on from moisturizing, speckle dispelling, red and swollen 3 indexs of elimination。

(1) moistening effect

Use crowd: choose women 40 people in 18-28 year, be randomly divided into four groups；Choose women 40 people in 28-38 year, be randomly divided into four groups。

Using method: after using the crowd's every day of face cleaning sooner or later, smear the skin care item of embodiment and reference examples, add up effect after using 15 days。

Effect assessment: use skin care item after 15 days, if skin of face becomes moistening exquisiteness before relatively using, has elastic force, and dried bark on the face disappears, obvious for moistening effect；Otherwise, for DeGrain。Statistical result is in Table 2。

Table 2 embodiment 1-3 compositions and reference examples skin repair liquid moistening effect log

Can obtain from the data of table 2, according to 18-28 year use the feedback of crowd, it is believed that the obvious number of compositions moistening effect respectively 8 people that embodiment 1-3 obtains, 7 people and 8 people, the obvious rate of effect all surpasses 70%；And think that the obvious number of moistening effect of reference examples skin repair liquid is only 5 people, the obvious rate of effect is only 50%。According to 28-38 year use the feedback of crowd, it is believed that the obvious number of compositions moistening effect respectively 9 people that embodiment 1-3 obtains, 7 people and 7 people, the obvious rate of effect all surpasses 70%；And think that the obvious number of moistening effect of reference examples skin repair liquid is only 4 people, the obvious rate of effect is only 40%。In sum, it is obvious that what embodiment of the present invention 1-3 provided has the compositions moistening effect repairing skin function, skin can be made to become moistening exquisiteness, have elastic force after using, and dried bark on the face disappears。

(2) freckle effect

Use crowd: choose 30-40 year women patient with chloasma 80 people, patient facial region has well-defined bigger speckle, mostly occurs in Face and cheek, nose, cheekbone portion, speckle color be brown or pitchy deeply brown, grey。80 patients are randomly divided into 4 groups, on average often organize 20 people, use the skin care item of embodiment 1-3 and reference examples respectively。

Using method: after using the crowd's every day of face cleaning sooner or later, smear the skin care item of embodiment and reference examples, add up effect after using 30 days。

Effect assessment: " clinical diagnosis of chloasma and the criterion of therapeutical effect " formulated with reference to Dermatology Professional Committee of CAIM (Chinese Association Of Integrative Medicine) pigment disease group, cut down degree and color change according to mottle area, curative effect is divided into basic healing, effective, improvement and invalid 4 grades。

Basic healing: perusal mottle area is cut down more than more than 90%, and color disappears substantially；

Effective: perusal mottle area is cut down more than 60%, and color is substantially thin out；

Take a turn for the better: perusal mottle area is cut down more than 30%, and color is thin out；

Invalid: perusal mottle area is cut down less than 30%, color change is inconspicuous。

Statistical result is in Table 3。

Table 3 embodiment 1-3 compositions and reference examples skin repair liquid freckle effect log

	Basic healing	Effective	Take a turn for the better	Invalid
					Embodiment 1	8	7	3	2
Embodiment 2	6	8	4	2
					Embodiment 3	5	8	4	3
Reference examples	2	3	10	5

Can obtaining from the data of table 3, the compositions that embodiment 1-3 obtains, after patient with chloasma uses, basic healing number respectively 8 people, 6 people and 5 people, cure rate is all more than 25%；Effective number respectively 7 people, 8 people and 8 people。And patient with chloasma uses the skin repair liquid of reference examples, basic healing number is only 2 people, and cure rate is only 10%, and effective number is only 3 people。In sum, it is obvious that what embodiment of the present invention 1-3 provided has the compositions freckle effect repairing skin function, and the mottle abatement effect using rear patient with chloasma is obvious, and effect is better than the skin repair liquid of reference examples。

(3) skin hypersensitivity is eliminated red and swollen

Use crowd: choose 18-28 year red and swollen women 80 people of skin allergy, be randomly divided into 4 groups, on average often organize 20 people, use the skin care item of embodiment 1-3 and reference examples respectively。

Using method: after morning and evening every day face cleaning, smear the skin care item of embodiment and reference examples, do not apply other skin care item。Effect is added up after using 15 days。

Effect assessment: use skin care item after 15 days, disappears if red and swollen, and desquamation phenomenon reduces, and presents water profit state, obvious for eliminating skin hypersensitivity redness effect；Otherwise, for DeGrain。Statistical result is in Table 4。

Table 4 embodiment 1-3 compositions and reference examples skin repair liquid eliminate red and swollen effect recording table

	Effect is obvious	DeGrain
			Embodiment 1	15	5
Embodiment 2	17	3
			Embodiment 3	16	4
Reference examples	10	10

Can obtain from the data of table 4, the compositions that embodiment 1-3 obtains, can effectively eliminate skin hypersensitivity redness, the obvious rate of effect respectively 75%, 85% and 80%, and the effective percentage that the skin repair liquid of reference examples eliminates skin hypersensitivity red and swollen is only 50%。Namely the compositions with skin repair function that embodiment of the present invention 1-3 provides, can effectively eliminate redness, makes desquamation phenomenon reduce and recovers water profit state。

It will be apparent to those skilled in the art that can technical scheme as described above and design, make other various corresponding changes and deformation, and all these change and deformation all should belong within the protection domain of the claims in the present invention。

Claims (10)

1. one kind has the compositions repairing skin function, it is characterised in that include following component by weight percentage: functional components 4.5-16%, additive 5-10% and deionized water 74-90%；The percentage by weight sum of mentioned component is 100%；

Wherein, described functional components includes by described composition weight percentages following component: glycosylglycerol 1-3%, phosphoinositide choline salt 0.5-0.8%, ceramide 0.5-2%, glucosan 1-5%, Radix Scutellariae extract 0.5-1.5%, Radix Sophorae Flavescentis extract 0.5-1.5%, Radix Glycyrrhizae extract 0.5-1.5%。

2. according to claim 1 have the compositions repairing skin function, it is characterized in that, described functional components includes by described composition weight percentages following component: glycosylglycerol 1.5-2.5%, phosphoinositide choline salt 0.6-0.8%, ceramide 0.5-1.5%, glucosan 2-4%, Radix Scutellariae extract 0.5-1%, Radix Sophorae Flavescentis extract 0.5-1%, Radix Glycyrrhizae extract 0.5-1%。

3. according to claim 1 have the compositions repairing skin function, it is characterized in that, described functional components includes by described composition weight percentages following component: glycosylglycerol 2%, phosphoinositide choline salt 0.7%, Cer EOS %, glucosan 3%, Radix Scutellariae 0.5%, Radix Sophorae Flavescentis 0.5%, Radix Glycyrrhizae 0.5%。

4. according to claim 1 have the compositions repairing skin function, it is characterised in that described additive includes by described composition weight percentages following component: emulsifying agent 1-2%, thickening agent 1-2%, wetting agent 3-5%, preservative 0.2-1%。

5. according to claim 4 have the compositions repairing skin function, it is characterised in that described emulsifying agent is the one of which in natural fatty alcohol, two polyglycereol, fatty acid ester, alkyl polyglucoside, glyceryl monostearate and hydrolecithin or combination in any。

6. according to claim 4 have the compositions repairing skin function, it is characterised in that described thickening agent is the one of which in pectin, hyaluronate sodium, hydroxyethyl cellulose, lauryl alcohol, cellulose gum, guar gum or combination in any。

7. according to claim 4 have the compositions repairing skin function, it is characterised in that described wetting agent is the one of which in ethylene glycol, glycerol, hyaluronic acid, pyrrolidone sodium carboxylate and chitin or combination in any。

8. according to claim 4 have the compositions repairing skin function, it is characterised in that described preservative is the one of which in three pears acid, three potassium sorbates, vitamin E and tea tree ethereal oil or combination in any。

9. according to claim 4 have the compositions repairing skin function, it is characterised in that includes following component by weight percentage: functional components 4.5-16%, additive 5-10% and deionized water 74-90%；The percentage by weight sum of mentioned component is 100%；

Wherein, described functional components includes by described composition weight percentages following component: glycosylglycerol 1.5-2.5%, phosphoinositide choline salt 0.6-0.8%, ceramide 0.5-1.5%, glucosan 2-4%, Radix Scutellariae extract 0.5-1%, Radix Sophorae Flavescentis extract 0.5-1%, Radix Glycyrrhizae extract 0.5-1%；

Described additive includes by described composition weight percentages following component: emulsifying agent 1-1.5%, thickening agent 1-1.5%, wetting agent 3.5-5%, preservative 0.2-0.8%。

10. according to claim 4 have the compositions repairing skin function, it is characterised in that includes following component by weight percentage: functional components 8.2%, additive 8.5% and deionized water 83.3%；The percentage by weight sum of mentioned component is 100%；

Wherein, described functional components includes by described composition weight percentages following component: glycosylglycerol 2%, phosphoinositide choline salt 0.7%, Cer EOS %, glucosan 3%, Radix Scutellariae extract 0.5%, Radix Sophorae Flavescentis extract 0.5%, Radix Glycyrrhizae extract 0.5%；

Described additive includes by described composition weight percentages following component: emulsifying agent 1.5%, thickening agent 1.5%, wetting agent 5%, preservative 0.5%。