CN109432400A

CN109432400A - A kind of trichogenous composition and its application

Info

Publication number: CN109432400A
Application number: CN201811608762.4A
Authority: CN
Inventors: 韦瑛
Original assignee: Shenzhen Fumeifu Gene Technology Co Ltd
Current assignee: Shenzhen Fumeifu Gene Technology Co Ltd
Priority date: 2018-12-27
Filing date: 2018-12-27
Publication date: 2019-03-08

Abstract

The invention discloses a kind of trichogenous compositions, including Tetrandrine, cyclic adenosine monophosphate, Fullerol and panthenol and trichogenous composition to promote the application in hair growth product in preparation.The trichogenous composition of the present invention can effectively activate hair follicle, strengthen cell-tocell access, prevent DHT from attacking hair follicle, and enhancing hair follicle nipple activity promotes hair follicle cell proliferation, prevents and treats alopecia；Promote human body and horn protein gene and collagen gene expression to generate more polyhedrin protein and collagen, promotes the supplement of growth and the nutrition of hair, have reached the effect of strengthen the hair, hair care and hair care；Quantity, density, length, the glossiness of hair, pitch black degree, dense degree, solidness and sturdy degree can be quicklyd increase.

Description

A kind of trichogenous composition and its application

Technical field

The invention belongs to pharmacy and cosmetology technical field, specifically a kind of trichogenous composition and its answer With.

Background technique

Hair, eyebrow and eyelashes missing or Sparse Problems, not only influence the appearance of a people, also will cause the various psychology of patient Disease.There is grinding for the research for being dedicated to solving hair, eyebrow and eyelashes missing or Sparse Problems, especially hair missing in each state Study carefully.Alopecia affects the male of 20% 20 years old age bracket, with advancing age, is increased with every 10 years 10% speed, That is 50 years old or so male, will have 50% to suffer from alopecia.95% alopecia is caused by male sex hormone, is deposited with hair root sheath 5 α-lidarutase enzymes it is related, male sex hormone testosterone (testostearone) can be converted to 5 by 5 α-lidarutase enzymes α-dihydrotestosterone (5 α-DHT), 5 α-DHT play the role of inhibiting hair matricyte, and sebaceous glands is made to activate and sebum secretion is promoted to flow Property fat, so that hair luster is prevented drying, if smegma increase, influence hair follicle development so that hair follicle becomes smaller, hair become Carefully, so as to cause a large amount of hair fall in flakes；Otherwise hair is then thicker, is hardened, blackening.It is more than women that this explains male pattern baldnesses The reason of, and women such as disease, weight or menopause, (estrogen secretion at this time plunged, and cannot offset in body body-internal-circulation Male sex hormone), be possible to alopecia.

Hair is a kind of keratoprotein, the hair root two parts composition being broadly divided under the hair shaft and skin on skin.Hair follicle It is the bourse for being enclosed in root of hair, is the skin histology for enabling hair growth, is the pass for promoting hair keratoprotein to generate Key position.Normal great-hearted hair follicle, is connected by the papilla of basal part with the capillary in skin, and these blood vessels Nutrition is then shipped to by blood circulation by hair.Collagen in skin is then the supply station of trichotrophy, root of hair The abundance of collagen can make hair tough securely.The micro- sem observation in hair cross section: bosom is hair marrow, intermediate It is collagen, outermost one layer is hair scale piece.Collagen mainly controls thick children, elasticity and the wettability of hair.It is each Root hair all originates in the cream of the hair at dermis of skin, it forms a ball top, then, passes through the cell point of keratinocyte It splits, promotes growing up to for a hair.The growth cycle of hair, eyebrow and eyelashes is similar, is divided into growth period-amortization period-and stops Only phase, difference are its growth cycle time differences.The early growth period service life of hair is about 2-6, enters stand-down later and takes off It falls, daily growth length about 0.3mm.Eyelashes average growth rate is (0.12 ± 0.05) mm/ days, substantially less than hair 0.3mm/ It the speed of growth, eyelashes growth cycle are estimated as about 5-6 a month, wherein duration in growth period average out to (34 ± 9) day. Eyebrow growth cycle is about 2 months, grows about 0.2mm daily.

For hair, eyebrow and eyelashes missing or Sparse Problems, according to severity, the therapeutic scheme used is different.Hand Art therapy has skin flap transplantation expander method, but operation wound is big, locally stays scar, and convalescence is long, and patient is generally unwilling to receive； Hair loss transplants healthy hair follicle to alopecia position, allows it to grow new hair, surgical procedure is improper, can be easy to cause Hair follicle necrosis.Alopecia such as Bimatoprost is prevented and treated in terms of drug, also known as Bimatoprost, dew secretes root etc., which is the U.S. The ingredient that the prescription medicine Lumigan (Lu Meigen) for the treatment glaucoma that Allergan company will produce in the end of the year 2006 is included, can promote Eyelashes growth then produces eyelash growing liquid as raw material by many cosmetics companies, but Bimatoprost excessively will cause Optic nerve injury may cause visual impairment and even blind, furthermore may also result in the symptoms such as retina swelling and inflammatory eye. Minoxidil (Minoxidil) is the drug for being clinically usually used in hair therapy at present, is found in the U.S., and FDA ratifies in male It can make most of male and female androgenetic hair loss patient really in women with 2% minoxidil of local use Macroscopic hair/fine is grown, however, it was found that the side effect of administration includes that scalp irritation and facial hair increase, this Outside, it whether effective at least needs that year is spent to assess this drug.

It is used in recent years with the Chinese herbal treatment alopecia with nourishing qi and blood, promoting circulation of blood dissolving stasis, the turbid function through dredging collateral, is passed through Local stimulation scalp, the Chinese herbal medicine extract to promote blood circulation are primary raw material, then are equipped with auxiliary material and form.But Chinese herbal medicine The mechanism of action is indefinite, and research also needs further deeply, and the extraction process of Chinese medicine is complicated, at high cost.

With biotech development, emerge one after another for hair growth and trichogenous Biochemical Drugs.Active peptides Paid attention to applied to alopecia and promotion hair regeneration is solved by dermatology, various countries and cosmetology expert, although using safe, But it is used alone, curative effect is not so good, and cost is also very high.

Summary of the invention

The purpose of the present invention is to provide a kind of trichogenous composition and its applications, to solve above-mentioned background skill The problem of being proposed in art.Composition of the invention, can be applied to generating hair reduce and/or there are the trouble of hair reduction Person, hair, eyelashes and eyebrow including patient etc..

To achieve the above object, the invention provides the following technical scheme:

One aspect of the present invention provides a kind of trichogenous composition, including Tetrandrine, cyclic adenosine monophosphate, fowler Pure and mild panthenol.

Preferably, a kind of trichogenous composition, according to the mass fraction, including 1-100 parts of Tetrandrine, ring phosphorus 1-100 parts of adenosine monophosphate, 1-500 parts of Fullerol, 10-100 parts of panthenol.

Including 10-80 parts of Tetrandrine, 10-80 parts of cyclic adenosine monophosphate, Fullerol 50- preferably, according to the mass fraction, 400 parts, 20-80 parts of panthenol.

Including 20-50 parts of Tetrandrine, 20-50 parts of cyclic adenosine monophosphate, Fullerol 100- preferably, according to the mass fraction, 250 parts, 20-80 parts of panthenol.

According to the mass fraction, including it is 30-40 parts of Tetrandrine, 30-40 parts of cyclic adenosine monophosphate, 150-200 parts of Fullerol, general 30-40 parts of alcohol.

Further, according to the mass fraction, the trichogenous composition further includes 0.1-100 parts of ciclosporin A

And/or 0.1-300 parts of Bimatoprost

And/or 50-500 parts of minoxidil.

Including 10-80 parts of ciclosporin A preferably, according to the mass fraction,

And/or 10-240 parts of Bimatoprost

And/or 50-400 parts of minoxidil.

Including 20-50 parts of ciclosporin A preferably, according to the mass fraction,

And/or 50-150 parts of Bimatoprost

And/or 100-250 parts of minoxidil.

Including 30-40 parts of ciclosporin A preferably, according to the mass fraction,

And/or 80-120 parts of Bimatoprost

And/or 150-200 parts of minoxidil.

Further, according to the mass fraction, the trichogenous composition further includes myristoyl pentapeptide -17 0.1-100 parts

And/or -16 0.1-100 parts of myristoyl hexapeptide.

Including -17 10-80 parts of myristoyl pentapeptide preferably, according to the mass fraction,

And/or -16 10-80 parts of myristoyl hexapeptide.

Including -17 20-50 parts of myristoyl pentapeptide preferably, according to the mass fraction,

And/or -16 20-50 parts of myristoyl hexapeptide.

Including -17 30-40 parts of myristoyl pentapeptide preferably, according to the mass fraction,

And/or -16 30-40 parts of myristoyl hexapeptide.

Further, the trichogenous composition further includes the penetration enhancer that mass concentration is 0.1-8%

And/or mass concentration is the moisturizer of 0.1-8%

And/or mass concentration is polyol class/Polyphenols preservative of 0.01-3%

And/or mass concentration is the comprehensive reagent of 0.01-8%.

Preferably, the penetration enhancer is ethyl alcohol, propylene glycol, oleyl alcohol, benzyl carbinol, Laurocapram, limonene, flores aurantii Alcohol, menthol, eugenol, cineol, myristic acid isopropyl propionate, isopropyl palmitate fat, the own rouge of palm acid ethyl, in Bai Chihua Ester, betulin, bisabolol, sandalwood oil, sesame seed oil, ginseng seed oil, levisticum officinale seed oil, rosemary leaf oil, thyme Caul-fat, frankincense oil, linolenic acid, the mixture of any one or more in evening primrose oil；

The moisturizer be glycerol, Natrulon H-10,20 carbon of Natrulon H-10, two acid esters/14 carbon, two esters of gallic acid, gather it is sweet Oily -10 dioleates, Natrulon H-10 myristinate, Natrulon H-10 diisopstearate, propylene glycol, polypropylene glycol, aloe Glue, sodium chondroitin sulfate, deer-bone collagenous albumen, Sodium Hyaluronate, threonine, citrulling, alanine, polyglutamic acid sodium, egg ammonia Acid, leucine, creatine, glycylglycine, tremella polysaccharides, panaxan, Radix Angelicae Sinensis polysaccharide, in astragalus polyose any one or A variety of mixtures；

The polyalcohols/Polyphenols preservative be Phenoxyethanol, 1,2- pentanediol, pungent glycol, chamenol, Kaempferol, The mixture of any one or more in Paeonol；

The comprehensive reagent is 1,2- hexylene glycol, Sensiva SC50, propylene glycol/10- hydroxydecanoic acid, aurantiamarin methyl Chalcone, zinc glycyrrhizate, ketoconazole, VitAVitE, tea oil, benzalkonium chloride, chlorogenic acid, lipoic acid, cytidine, DNA, adenosine phosphate, cytimidine, adenosine, phytosterol, choline, vitamin B6, vitamin B3, folic acid, niacinamide, Chrysin, Oleanolic acid, asparagine, biotin, theophylline, capsaicine, quinin hydrochloride, hydrolysis sesame protein, hydrolysis placenta (sheep) are extracted Object, ginkegetin, taurine, the mixture of any one or more in caffeine.

Further, the trichogenous composition further include mass concentration be 0.1-3% pH adjusting agent and/ Or mass concentration be 0-2% tackifier and/or mass concentration be 0-5% emulsifier.

Preferably, the pH adjusting agent is arginine, sodium bicarbonate, saleratus, dipotassium hydrogen phosphate, potassium hydrogen phosphate, cream Acid, salicylic acid, aspartic acid, one of pyroglutamic acid, malic acid, citric acid or a variety of mixtures；

The tackifier are one of Sodium Hyaluronate, xanthan gum, cellulose, carbomer, gelatin or a variety of mixing Object.

Further, the pH value range of the trichogenous composition is 4.0~8.0.

As it is a further object of the present invention to provide above-mentioned trichogenous compositions in preparation promotion hair growth Application in product.

Compared with prior art, the beneficial effects of the present invention are:

The trichogenous composition of the present invention can effectively activate hair follicle, strengthen cell-tocell access, prevent DHT Hair follicle is attacked, enhancing hair follicle nipple activity promotes hair follicle cell proliferation, prevents and treats alopecia；Promote human body and animal Keratin gene and collagen gene expression generate more polyhedrin protein and collagen, promote the benefit of growth and the nutrition of hair It fills, strengthen the hair, hair care and hair care；Quantity, density, length, the glossiness of hair, pitch black degree, dense degree, solidness can be quicklyd increase With sturdy degree.

By human trial, any formula of the composition compared with 2% minoxidil and 0.3% bimatoprost, Promote hair growth or inhibit in trichomadesis, hence it is evident that is better than minoxidil and bimatoprost, this is clinical treatment alopecia Or hair growth is promoted to provide new drug foundation.

Numerous experimental datas are proved: the effective component of any formula of the composition has confirmed with hair growth between having It connects or direct function and effect, and has a large amount of clinical data.

If Tetrandrine is a kind of natural products extracted from Chinese medicine Radix Stephaniae Tetrandrae root, it has extensive pharmacological action, It is a multiple target point drug molecule, there is antibacterial, anti-inflammatory, antiallergy, antiviral, anticancer, analgesia, loose muscle, promote hair raw The effects of long.Tetrandrine is acted as in terms of promoting hair growth by following number of ways: a. hair follicle stimulating epithelial cell Proliferation and differentiation, can increase papilla, hair matrix, external root sheath and hair surrounding annulus cell synthesis quantity, to prolong Long hair growth period.B. the infiltration for reducing perifollicolar lymphocyte, biopsy discovery responder's hair follicle is restored to normally after treatment Size, dermal vascular bore increase, and the infiltration of peripheral lymphocyte disappears.C. promote angiogenesis, increase local blood and supply It answers.Tetrandrine can raise the expression of the mRNA of human hair papilla cell VEGF, thus, hair follicle and hair are stimulated and maintained by VEGF Nipple vascularization and function increase local blood supply, increase the blood flow of skin and hair follicles, be conducive to the confession of skin Oxygen makes to restore normal lower than the temperature of normal skin simultaneously, provides advantage for hair growth.D. potassium channel is opened, can be increased Add the permeability of potassium ion, prevent calcium ion from flowing into intracellular, free calcium ion concentration in cell is caused to decline.In the presence of calcium, Epidermal growth factor hair growth inhibition, therefore Tetrandrine can reduce inhibition of the epidermal growth factor to hair growth, make hair Growth is accelerated.E. inhibit the secretion of testosterone, to control trichomadesis, stimulate hair regeneration.Clinical test shows that the Chinese is anti- Alkali is nontoxic, also non-stimulated to skin.

Cyclic adenosine monophosphate is present in normal cell, is effect of the ATP through adenyl cyclase and generates.As hormone and The second messenger of neurotransmitter plays a role.It can strengthen cell-tocell access, prevent DHT from attacking hair follicle, enhance hair follicle Nipple activity promotes hair follicle cell proliferation, prevents and treats alopecia；Promote human body and horn protein gene and collagen Gene expression generates more polyhedrin protein and collagen, reinforces local microcirculation and increases blood flow, promotes growth and the battalion of hair Feeding supplement, strengthen the hair, hair tonic, hair care, Anti-hair loss and hair care.

Fullerol (C60 (OH) n) is a kind of water-soluble nano fullerene derivate, in biomedical and cosmetic field table Excellent performance is revealed.It remove with very strong free radical scavenging ability, excellent antioxidant activity, antibiotic property, anti-aging, Outside the physiological activity such as radiation resistance and cancer resistance, its energy penetrating cell film can effectively activate hair follicle, promote the generation of hair follicle, divide Change and grow, makes more pitch-black, bright, dense, the hard Cobalt of the hair grown, submissive, sturdy, the property and peace for having good biological compatible Total stability.

Panthenol is also known as dexpanthenol, participates in protein, sugar and fat metabolism in vivo, can be used as nutritional supplement And hardening agent.In cosmetics and in external drug, transdermal penetration power is strong, can invigorate blood circulation, and reinforces microcirculation, can accelerate epidermis shape At promotion skin regeneration increases moisture content of skin, makes skin emolliency, exquisiteness, rejuvenation.It can also promote wound healing, and have Good anti-inflammatory effect.During protecting hair, panthenol enters hair shaft, there is lasting moisture-keeping functions, can prevent hair jag, by Damage increases hair density, stimulation hair growth, improves hair luster degree.

Clinical test shows that ciclosporin A has apparent growth promoting function to hair follicle, which not only shows extension hair follicle Growth period, and can promote hair follicle cell proliferation, differentiation and migration, induce perifollicolar vascularization.Its mechanism of action is On the one hand ciclosporin A can extend the mRNA expression of papilla vascular endothelial growth factor (VEGF), stimulation and maintenance hair follicle With the vascularization and function of papilla；On the other hand, extend the table of hepatocyte growth factor (HGF) mRNA by upper reconciliation It reaches, stimulates the proliferation of hair matricyte, promote hair follicle growth.

Bimatoprost (bimatroprost) can stimulate intercellular signal conduction path, and horn cell is caused to generate The growth and melanocyte chromogenesis calmness for increasing hair increase, and hair follicle is induced to enter growth period from stand-down；Extend Anagen phase is to extend entire hair cycle；Stimulation papilla secretes cytokine profiles or growth factor to promote indirectly Into hair growth；Adjust the expression of adhesion molecule；Increase the synthesis etc. of protease.Bimatoprost is not only temporarily to keep Hair is longer in stage anagen, it actually changes skin biology and paracrine signal on a cellular level (cell-cell communication) may finally will increase the protection to DHT.Clinical test is all very optimistic, but it has apparent pair It acts on (mainly black eye, iris are dimmed, black eye eyelid etc.), Bimatoprost excessively will cause optic nerve injury, may Cause visual impairment even to be blinded, furthermore may also result in the symptoms such as retina swelling and inflammatory eye.

Minoxidil (Minoxidil) is potassium channel openers, has powerful expansion blood vessel function, is mainly used for treating Severe, resistant hypertension medicine, while having again and promoting hair regeneration effect, confrontation androgens psilosis, alopecia areata have a better effect. Minoxidil is promoting hair growth, prevents trichomadesis, is realized by following number of ways: a. hair follicle stimulating epithelium The proliferation and differentiation of cell can increase papilla, hair matrix, the quantity of external root sheath and the synthesis of hair surrounding annulus cell, from And extend the anagen phase, promote fine hair to convert to terminal hair.B. perifollicolar lymphocytic infiltration is reduced.It is found after treatment effective Person's hair follicle is restored to normal size, and dermal vascular bore increases, and peripheral lymphocyte infiltration disappears.C. promote angiogenesis, Increase local blood supply.Hair growth supplies nutrition by the blood vessel network of papilla, in the different growth periods of hair, blood The mRNA of endothelial cell growth factor expresses difference, and growth period, Vascular endothelial growth factor mRNA was in dermal papilla cell Middle strong expression, but then express in catagen and stand-down less.Experiment shows that minoxidil increases blood vessel in dose dependent The expression of endothelial growth factor mRNA and its albumen increase local blood supply to promote papilla vascularization. D. open potassium channel: potassium channels opening is the important step of regulating hair growth, and the inside and outside experiment of animal model shows rice Promise you be potassium channel activator, can increase the permeability of potassium ion, prevent calcium ion from flowing into intracellular, as a result cause in cell Free calcium ion concentration decline, and when having calcium ion, epidermal growth factor hair growth inhibition.

The mechanism of action of myristoyl pentapeptide -17 and myristoyl hexapeptide -16 be it is identical, can effectively activate hair follicle, or It activates keratoprotein gene or stimulates the expression of keratin gene, promote the synthesis of the keratin of hair, to promote hair (eyelash Hair, eyebrow, hair) growth, keep hair denser, more sturdy, more tough and tensile.

In this experiment, any formula is inhibiting trichomadesis or is promoting in hair growth in the composition object, and above Single active ingredient is compared, and has the effect of being substantially better than single active ingredient, and Small side effects, is shown significantly to cooperate with and be made With.

Specific embodiment

Below in conjunction with the embodiment of the present invention, technical scheme in the embodiment of the invention is clearly and completely described, Obviously, described embodiments are only a part of the embodiments of the present invention, instead of all the embodiments.Based in the present invention Embodiment, every other embodiment obtained by those of ordinary skill in the art without making creative efforts, all Belong to the scope of protection of the invention.

Trichogenous composition of the invention, including Tetrandrine, cyclic adenosine monophosphate, Fullerol and panthenol.It should Composition can be used for preparing trichogenous product, and trichogenous product can be applied to educate hair hair care neck Domain, eyelashes field and eyebrow field.The kenel of the product can be lotion, shampoo, washing lotion, creme, spray, gel, put on the skin One of agent, tincture, solution, aerosol, plastics, patch, paste, ointment and paste.

Trichogenous composition of the invention is when being made lotion, the composite formula dissolution of raw material by design Or it is scattered in formation homogeneous latex emulsion body in emulsion type matrix, lotion is made.

Trichogenous composition of the invention is when being made shampoo, the composite formula dissolution of raw material by design Or be scattered in shampoo type matrix and form homogeneous mixture, hair tonic is made, educates hair, hair care, strengthen the hair, black hair, anticreep hair style The shampoo of one or more functions.

Trichogenous composition of the invention is when being made washing lotion, the composite formula dissolution of raw material by design Uniform liquid is formed in shampoo type matrix, washing lotion is made.

Trichogenous composition of the invention is when being made creme, the composite formula dissolution of raw material by design In solvent, suitable surfactant, emulsifier, moisturizer, bacteriostatic agent, preservative, antioxidant or cutaneous permeable agent is added In the creme Deng made of, creme is made.

Trichogenous composition of the invention when spray is made, by design composite formula raw material with The additives such as proper auxiliary materials such as solvent, cosolvent, antioxidant, bacteriostatic agent, preservative, cutaneous permeable agent, surfactant are miscible It is filled in the device of speciality, spray is made.

Trichogenous composition of the invention is when being made gel, the composite formula dissolution of raw material by design Or be scattered in gel base and form homogeneous mixture, gel is made.

Trichogenous composition of the invention is when being made liniment, the composite formula raw material and second by design Alcohol, oil or suitable solvent and thickener, are made liniment.

Long composition occurs for promotion of the invention when tincture is made, and second is added in the composite formula raw material for pressing design Tincture is made to formula ratio in alcoholic solution.

Trichogenous composition of the invention is when being made solution, the composite formula raw material second by design Alcohol, vegetable oil, propylene glycol, the dissolution of Natrulon H-10 equal solvent, are made solution.

Trichogenous composition of the invention when spray is made, by design composite formula raw material with The additives such as proper auxiliary materials such as solvent, cosolvent, antioxidant, bacteriostatic agent, preservative, cutaneous permeable agent, surfactant are miscible, Again with suitable propellant (NO, CO₂Deng) be filled in the device of speciality, aerosol is made.

Trichogenous composition of the invention is molten the composite formula raw material by design when plastics are made It solves or is scattered in the solvent containing filmogen, plastics are made.

Trichogenous composition of the invention the composite formula raw material by design and is fitted when patch is made Suitable matrix is made paste, is coated on back lining materials, and patch is made.

Trichogenous composition of the invention is when being made paste, the composite formula stock dispersion by design Uniform semisolid preparation is formed in suitable water-soluable gel or oil-soluble gel-type vehicle, paste is made.

The of the invention Chinese medicine compound prescription that there is stimulation hair growth effect to be used for hair growth is when being made ointment, pressing The composite formula raw material of design is mixed with suitable oil or water-soluble base, and ointment is made.

Trichogenous composition of the invention is molten the composite formula raw material by design when cream is made It solves or is scattered in emulsus paste type matrix and form uniform semisolid mixture, paste is made.

The dosage of Tetrandrine can be 1,2,3,5,10,15,20,30,40,50,60,70,80,90 in present embodiment Or 100 mass parts, it is also possible in the range of these any two value, preferably 10-80 mass parts, more preferably 20-50 Mass parts, most preferably 30-40 mass parts.

In present embodiment the dosage of cyclic adenosine monophosphate can be 1,2,3,5,10,15,20,30,40,50,60,70,80, 90 or 100 mass parts, are also possible in the range of these any two value, preferably 10-80 mass parts, more preferably 20- 50 mass parts, most preferably 30-40 mass parts.

In present embodiment the dosage of Fullerol can be 1,2,3,5,10,15,20,30,40,50,60,70,80,90, 100,120,150,200,250,300,350,400,450 or 500 mass parts are also possible to the range of these any two value It is interior, preferably 50-400 mass parts, more preferably 100-250 mass parts, most preferably 150-200 mass parts.

In present embodiment the dosage of panthenol can be 1,2,3,5,10,15,20,30,40,50,60,70,80,90 or 100 mass parts are also possible in the range of these any two value, preferably 10-80 mass parts, more preferably 20-50 matter Measure part, most preferably 30-40 mass parts.

As another embodiment of the present invention, ciclosporin A can also be added in above-mentioned composition, dosage can be 0.1, 0.2,0.3,0.5,1,2,3,5,10,15,20,30,40,50,60,70,80,90 or 100 mass parts are also possible to appointing for these It anticipates two in the range of being worth, preferably 10-80 mass parts, more preferably 20-50 mass parts, most preferably 30-40 mass parts

And/or Bimatoprost, dosage can be 0.1,0.2,0.3,0.5,1,2,3,5,10,15,20,30,40, 50,60,70,80,90,100,120,150,200,250 or 300 mass parts are also possible to the range of these any two value It is interior, preferably 10-240 mass parts, more preferably 50-150 mass parts, most preferably 80-120 mass parts

And/or minoxidil, dosage can be 50,60,70,80,90,100,120,150,200,250,300,350, 400,450 or 500 mass parts are also possible in the range of these any two value, preferably 50-400 mass parts, more preferably For 100-250 mass parts, most preferably 150-200 mass parts.

As another embodiment of the present invention, myristoyl pentapeptide -17 can also be added in above-mentioned composition, dosage can To be 0.1,0.2,0.3,0.5,1,2,3,5,10,15,20,30,40,50,60,70,80,90 or 100 mass parts, it is also possible to In the range of these any two value, preferably 10-80 mass parts, more preferably 20-50 mass parts, most preferably 30-40 Mass parts

And/or myristoyl hexapeptide -16, dosage can be 0.1,0.2,0.3,0.5,1,2,3,5,10,15,20,30, 40,50,60,70,80,90 or 100 mass parts are also possible in the range of these any two value, preferably 10-80 mass Part, more preferably 20-50 mass parts, most preferably 30-40 mass parts.

The infiltration that mass concentration is 0.1-8% can also be added as another embodiment of the present invention, in above-mentioned composition Saturating promotor, specially ethyl alcohol, propylene glycol, oleyl alcohol, benzyl carbinol, Laurocapram, limonene, nerol, menthol, cloves It is phenol, cineol, myristic acid isopropyl propionate, isopropyl palmitate fat, the own rouge of palm acid ethyl, white pond flower lactone, betulin, red Bisabol, sandalwood oil, sesame seed oil, ginseng seed oil, levisticum officinale seed oil, rosemary leaf oil, thyme caul-fat, frankincense oil, Asia The mixture of any one or more in numb acid, evening primrose oil

And/or mass concentration is the moisturizer of 0.1-8%, specially glycerol, Natrulon H-10,20 carbon two of Natrulon H-10 Acid esters/14 carbon, two esters of gallic acid, Natrulon H-10 dioleate, Natrulon H-10 myristinate, two isostearic acid of Natrulon H-10 Ester, propylene glycol, polypropylene glycol, Aloe Vera Gel, sodium chondroitin sulfate, deer-bone collagenous albumen, Sodium Hyaluronate, threonine, citrulling, Alanine, polyglutamic acid sodium, methionine, leucine, creatine, glycylglycine, tremella polysaccharides, panaxan, Radix Angelicae Sinensis polysaccharide, The mixture of any one or more in astragalus polyose

And/or mass concentration is polyol class/Polyphenols preservative of 0.01-3%, specially Phenoxyethanol, 1,2- penta 2 Alcohol, pungent glycol, chamenol, Kaempferol, the mixture of any one or more in Paeonol

And/or mass concentration is the comprehensive reagent of 0.01-8%, specially 1,2- hexylene glycol, Sensiva SC50, third Glycol/10- hydroxydecanoic acid, aurantiamarin methyl chalcone, zinc glycyrrhizate, ketoconazole, VitAVitE, tea oil, benzene are pricked Oronain, chlorogenic acid, lipoic acid, cytidine, DNA, adenosine phosphate, cytimidine, adenosine, phytosterol, choline, vitamin B6, dimension life Plain B3, folic acid, niacinamide, Chrysin, oleanolic acid, asparagine, biotin, theophylline, capsaicine, quinin hydrochloride, hydrolysis sesame Numb albumen hydrolyzes placenta (sheep) extract, ginkegetin, the mixture of any one or more in taurine, caffeine.

The pH that mass concentration is 0.1-3% can also be added as another embodiment of the present invention, in above-mentioned composition Regulator, specially arginine, sodium bicarbonate, saleratus, dipotassium hydrogen phosphate, potassium hydrogen phosphate, lactic acid, salicylic acid, asparagus fern ammonia Acid, one of pyroglutamic acid, malic acid, citric acid or a variety of mixtures

And/or mass concentration is the tackifier of 0-2%, specially Sodium Hyaluronate, xanthan gum, cellulose, carbomer, bright One of glue or a variety of mixtures

And/or mass concentration is the emulsifier of 0-5%.

As another embodiment of the present invention, the pH value range of above-mentioned composition is 4.0~8.0.

Embodiment 1

In the embodiment of the present invention, a kind of trichogenous composition, including following raw material by weight: Radix Stephaniae Tetrandrae 3 parts of alkali, 1 part of cyclic adenosine monophosphate, 1 part of Fullerol, 10 parts of panthenol.

The trichogenous composition of the present embodiment when lotion is made, by above-mentioned parts by weight dissolution of raw material in Contain 1% penetration enhancer, 5% moisturizer, 0.01% preservative, 3% comprehensive reagent, 0.5% tackifier and 3% emulsifier And homogeneous latex emulsion body is formed in emulsion type matrix made by surplus pure water, and be with pyroglutamic acid and arginine adjustment pH 6.0。

Lotion made of the present embodiment can be applied to educate hair hair care art, eyelashes field and eyebrow field.

Embodiment 2

In the embodiment of the present invention, a kind of trichogenous composition, including following raw material by weight: Radix Stephaniae Tetrandrae 100 parts of alkali, 100 parts of cyclic adenosine monophosphate, 500 parts of Fullerol, 100 parts of panthenol.

The trichogenous composition of the present embodiment when shampoo is made, by above-mentioned parts by weight dissolution of raw material in Containing 1.5% penetration enhancer, 5% moisturizer, 0.03% preservative, 3% comprehensive reagent, 0.5% tackifier and surplus are pure Homogeneous mixture is formed in shampoo type matrix made by water, and is 6.5 with lactic acid adjustment pH.

Shampoo made of the present embodiment can be applied to educate hair hair care art, eyelashes field and eyebrow field.

Embodiment 3

In the embodiment of the present invention, a kind of trichogenous composition, including following raw material by weight: Radix Stephaniae Tetrandrae 1 part of alkali, 40 parts of cyclic adenosine monophosphate, 0.1 part of Bimatoprost, 20 parts of Fullerol, 80 parts of panthenol.

The trichogenous composition of the present embodiment when washing lotion is made, by above-mentioned parts by weight dissolution of raw material in Contain 1.0% penetration enhancer, 1.5% moisturizer, 0.05% preservative, 3% comprehensive reagent, 0.3% tackifier and 0.5% Homogeneous mixture is formed in washing lotion type matrix made by emulsifier and surplus pure water, and is 5.5 with salcylic acid adjustment pH.

Washing lotion made of the present embodiment can be applied to educate hair hair care art, eyelashes field and eyebrow field.

Embodiment 4

In the embodiment of the present invention, a kind of trichogenous composition, including following raw material by weight: Radix Stephaniae Tetrandrae 2 parts of alkali, 20 parts of cyclic adenosine monophosphate, 300 parts of Bimatoprost, 10 parts of Fullerol, 50 parts of panthenol.

The trichogenous composition of the present embodiment when creme is made, by above-mentioned parts by weight dissolution of raw material in Contain 5% penetration enhancer, 5% moisturizer, 0.05% preservative, 3% comprehensive reagent, 0.3% tackifier and 5% emulsifier And homogeneous mixture is formed in white dosage form substrate made by surplus pure water, and be 5 with salcylic acid adjustment pH.

Creme made of the present embodiment can be applied to educate hair hair care art, eyelashes field and eyebrow field.

Embodiment 5

In the embodiment of the present invention, a kind of trichogenous composition, including following raw material by weight: Radix Stephaniae Tetrandrae 30 parts of alkali, 30 parts of cyclic adenosine monophosphate, 100 parts of Bimatoprost, 30 parts of Fullerol, 40 parts of panthenol.

The trichogenous composition of the present embodiment when spray is made, by above-mentioned parts by weight dissolution of raw material in Contain 5% penetration enhancer, 5% moisturizer, 0.05% preservative, 3% comprehensive reagent, 5% emulsifier and surplus pure water Homogeneous mixture solotion is formed in made liquid-type matrix, and is 5 with pyroglutamic acid adjustment pH, and be filled in the dress system of speciality In spray is made.

Spray made of the present embodiment can be applied to educate hair hair care art, eyelashes field and eyebrow field.

Embodiment 6

In the embodiment of the present invention, a kind of trichogenous composition, including following raw material by weight: Radix Stephaniae Tetrandrae 40 parts of alkali, 50 parts of cyclic adenosine monophosphate, 50 parts of minoxidil, 40 parts of Fullerol, 30 parts of panthenol.

The trichogenous composition of the present embodiment when gel is made, by above-mentioned parts by weight dissolution of raw material or It is scattered in containing 1.0% penetration enhancer, 5% moisturizer, 1% preservative, 3% comprehensive reagent, 1.5% tackifier and remaining Homogeneous mixture is formed in gel base made by amount pure water, and is 5.5 with pyroglutamic acid pH.

Gel made of the present embodiment can be applied to educate hair hair care art, eyelashes field and eyebrow field.

Embodiment 7

In the embodiment of the present invention, a kind of trichogenous composition, including following raw material by weight: Radix Stephaniae Tetrandrae 50 parts of alkali, 60 parts of cyclic adenosine monophosphate, 500 parts of minoxidil, 50 parts of Fullerol, 20 parts of panthenol.

The trichogenous composition of the present embodiment when liniment is made, by above-mentioned parts by weight dissolution of raw material in Containing 8.0% penetration enhancer, 8% moisturizer, 2% preservative, 8% comprehensive reagent, 2% tackifier, 5% emulsifier and It is put on the skin made by surplus ethyl alcohol, vegetable oil and forms homogeneous mixture in dosage form substrate, and be 5.5 with pyroglutamic acid pH.

Liniment made of the present embodiment can be applied to educate hair hair care art, eyelashes field and eyebrow field.

Embodiment 8

In the embodiment of the present invention, a kind of trichogenous composition, including following raw material by weight: Radix Stephaniae Tetrandrae 10 parts of alkali, 80 parts of cyclic adenosine monophosphate, 200 parts of minoxidil, 80 parts of Fullerol, 60 parts of panthenol.

The trichogenous composition of the present embodiment when tincture is made, by above-mentioned parts by weight dissolution of raw material in Containing 6.0% penetration enhancer, 5% moisturizer, 1.2% preservative, second made by 3% comprehensive reagent and surplus ethyl alcohol Uniform mixing liquid is formed in alcoholic solution tincture dosage form substrate, and is 6 with pyroglutamic acid pH.

Tincture made of the present embodiment can be applied to educate hair hair care art, eyelashes field and eyebrow field.

Embodiment 9

In the embodiment of the present invention, a kind of trichogenous composition, including following raw material by weight: Radix Stephaniae Tetrandrae 80 parts of alkali, 10 parts of cyclic adenosine monophosphate, -170.1 parts of myristoyl pentapeptide, 60 parts of Fullerol, 5 parts of panthenol.

The trichogenous composition of the present embodiment when solution is made, by above-mentioned parts by weight dissolution of raw material in Containing 7.0% penetration enhancer, 7% moisturizer, 1.2% preservative, solution made by 7% comprehensive reagent and excess water Homogeneous mixture solotion is formed in type matrix, and is 6 with pyroglutamic acid pH.

Solution made of the present embodiment can be applied to educate hair hair care art, eyelashes field and eyebrow field.

Embodiment 10

In the embodiment of the present invention, a kind of trichogenous composition, including following raw material by weight: Radix Stephaniae Tetrandrae 20 parts of alkali, 5 parts of cyclic adenosine monophosphate, -17100 parts of myristoyl pentapeptide, 5 parts of Fullerol, 1 part of panthenol.

The trichogenous composition of the present embodiment is when being made aerosol, the dissolution of raw material for pressing above-mentioned parts by weight In contain 6% penetration enhancer, 6% moisturizer, 1% preservative, 6% comprehensive reagent, 2% emulsifier and surplus pure water institute Homogeneous mixture is formed in manufactured liquid-type matrix, and is 6.3 with pyroglutamic acid adjustment pH, then be filled in propellant (NO) In the device of speciality, aerosol is made.

Aerosol made of the present embodiment can be applied to educate hair hair care art, eyelashes field and eyebrow field.

Embodiment 11

In the embodiment of the present invention, a kind of trichogenous composition, including following raw material by weight: Radix Stephaniae Tetrandrae 5 parts of alkali, 15 parts of cyclic adenosine monophosphate, -175 parts of myristoyl pentapeptide, 70 parts of Fullerol, 15 parts of panthenol.

The trichogenous composition of the present embodiment is when being made plastics, the dissolution of raw material for pressing above-mentioned parts by weight Or it is scattered in containing 6% penetration enhancer, 6% moisturizer, 1% preservative, 6% comprehensive reagent, 2% emulsifier and surplus Homogeneous mixture is formed in film-forming type matrix made by pure water, and is 6.2 with pyroglutamic acid adjustment pH.

Plastics made of the present embodiment can be applied to educate hair hair care art, eyelashes field and eyebrow field.

Embodiment 12

In the embodiment of the present invention, a kind of trichogenous composition, including following raw material by weight: Radix Stephaniae Tetrandrae 15 parts of alkali, 70 parts of cyclic adenosine monophosphate, 0.5 part of Bimatoprost, 100 parts of minoxidil, 150 parts of Fullerol, 90 parts of panthenol.

The trichogenous composition of the present embodiment when patch is made, by above-mentioned parts by weight dissolution of raw material or It is scattered in containing 5% penetration enhancer, 5% moisturizer, 1.1% preservative, 5% comprehensive reagent, 1.3% tackifier, 4.5% Homogeneous mixture is formed in paste type matrix made by emulsifier and surplus pure water, and is 6.4 with pyroglutamic acid adjustment pH, then It is coated on back lining materials and patch is made.

Patch made of the present embodiment can be applied to educate hair hair care art, eyelashes field and eyebrow field.

Embodiment 13

In the embodiment of the present invention, a kind of trichogenous composition, including following raw material by weight: Radix Stephaniae Tetrandrae 60 parts of alkali, 2 parts of cyclic adenosine monophosphate, 200 parts of Bimatoprost, 300 parts of minoxidil, 15 parts of Fullerol, 3 parts of panthenol.

The trichogenous composition of the present embodiment when paste is made, by above-mentioned parts by weight dissolution of raw material or It is scattered in containing 5.5% penetration enhancer, 5.5% moisturizer, 0.9% preservative, 5.5% comprehensive reagent, 1.5% thickening Mixed uniformly semisolid is formed in gel-type vehicle made by agent, 3.8% emulsifier and surplus pure water, and uses pyroglutamic acid Adjusting pH is 6.8.

Paste made of the present embodiment can be applied to educate hair hair care art, eyelashes field and eyebrow field.

Embodiment 14

In the embodiment of the present invention, a kind of trichogenous composition, including following raw material by weight: Radix Stephaniae Tetrandrae 90 parts of alkali, 2 parts of cyclic adenosine monophosphate, 50 parts of Bimatoprost, 150 parts of minoxidil, -1620 parts of myristoyl hexapeptide, fowler 300 parts of alcohol, 70 parts of panthenol.

The trichogenous composition of the present embodiment when ointment is made, by above-mentioned parts by weight dissolution of raw material or It is scattered in containing 4.5% penetration enhancer, 4.5% moisturizer, 1.1% preservative, 4.5% comprehensive reagent, 1.3% thickening Homogeneous mixture is formed in ointment bases made by agent, 4.5% emulsifier and surplus pure water, and is adjusted with pyroglutamic acid PH is 6.6

Ointment made of the present embodiment can be applied to educate hair hair care art, eyelashes field and eyebrow field.

Embodiment 15

In the embodiment of the present invention, a kind of trichogenous composition, including following raw material by weight: Radix Stephaniae Tetrandrae 70 parts of alkali, 90 parts of cyclic adenosine monophosphate, 5 parts of Bimatoprost, -171 parts of myristoyl pentapeptide, 120 parts of Fullerol, 2 parts of panthenol.

The trichogenous composition of the present embodiment when emulsifiable paste is made, by above-mentioned parts by weight dissolution of raw material or It is scattered in containing 4.5% penetration enhancer, 4.5% moisturizer, 1.1% preservative, 4.5% comprehensive reagent, 1.3% thickening Uniform semisolid mixture is formed in paste type matrix made by agent, 4.5% emulsifier and surplus pure water, and uses pyroglutamic acid Adjusting pH is 6.

Embodiment 16

In the embodiment of the present invention, a kind of trichogenous composition, including following raw material by weight: Radix Stephaniae Tetrandrae 25 parts of alkali, 3 parts of cyclic adenosine monophosphate, 120 parts of Bimatoprost, -16100 parts of myristoyl hexapeptide, 200 parts of Fullerol, panthenol 2 Part.

The trichogenous composition of the present embodiment when lotion is made, by above-mentioned parts by weight dissolution of raw material in Containing 5% penetration enhancer, 5% moisturizer, 0.5% preservative, 5% comprehensive reagent, 0.5 tackifier and 3% emulsifier and Homogeneous latex emulsion body is formed in emulsion type matrix made by surplus pure water, and is 6.0 with pyroglutamic acid and arginine adjustment pH.

Embodiment 17

In the embodiment of the present invention, a kind of trichogenous composition, including following raw material by weight: Radix Stephaniae Tetrandrae 45 parts of alkali, 45 parts of cyclic adenosine monophosphate, 150 parts of Bimatoprost, -160.5 parts of myristoyl hexapeptide, 100 parts of Fullerol, panthenol 25 parts.

Embodiment 18

In the embodiment of the present invention, a kind of trichogenous composition, including following raw material by weight: Radix Stephaniae Tetrandrae 30 parts of alkali, 40 parts of cyclic adenosine monophosphate, 30 parts of Bimatoprost, -160.1 parts of myristoyl hexapeptide, 400 parts of Fullerol, panthenol 50 parts.

The trichogenous composition further includes the penetration enhancer that mass concentration is 0.1%；Penetration enhancer For ethyl alcohol, propylene glycol, oleyl alcohol, benzyl carbinol, Laurocapram, limonene, nerol, menthol, eugenol, cineol, Pork and beans It is cool acid isopropyl propionate, isopropyl palmitate fat, the own rouge of palm acid ethyl, white pond flower lactone, betulin, bisabolol, sandalwood oil, Sesame seed oil, ginseng seed oil, levisticum officinale seed oil, in rosemary leaf oil, thyme caul-fat, frankincense oil, linolenic acid, evening primrose oil The mixture of any one or more.

A kind of trichogenous composition promotes the application in hair growth product in preparation, promotes hair growth Product can be applied to educate hair hair care art, eyelashes field and eyebrow field.

The kenel of the product can be lotion, shampoo, washing lotion, creme, spray, gel, liniment, tincture, solution, One of aerosol, plastics, patch, film, paste, ointment and paste.

Embodiment 19

In the embodiment of the present invention, a kind of trichogenous composition, including following raw material by weight: Radix Stephaniae Tetrandrae 40 parts of alkali, 50 parts of cyclic adenosine monophosphate, 80 parts of Bimatoprost, 20 parts of Fullerol, 80 parts of panthenol.

The trichogenous composition further includes the penetration enhancer that mass concentration is 8%；Penetration enhancer is Ethyl alcohol, propylene glycol, oleyl alcohol, benzyl carbinol, Laurocapram, limonene, nerol, menthol, eugenol, cineol, nutmeg The own rouge of sour isopropyl propionate, isopropyl palmitate fat, palm acid ethyl, white pond flower lactone, betulin, bisabolol, sandalwood oil, sesame Flaxseed oil, ginseng seed oil, levisticum officinale seed oil, in rosemary leaf oil, thyme caul-fat, frankincense oil, linolenic acid, evening primrose oil The mixture of any one or more.

Embodiment 20

In the embodiment of the present invention, a kind of trichogenous composition, including following raw material by weight: Radix Stephaniae Tetrandrae 30 parts of alkali, 40 parts of cyclic adenosine monophosphate, 10 parts of Bimatoprost, 90 parts of Fullerol, 80 parts of panthenol.

The trichogenous composition further includes the penetration enhancer that mass concentration is 5%；Penetration enhancer is Ethyl alcohol, propylene glycol, oleyl alcohol, benzyl carbinol, Laurocapram, limonene, nerol, menthol, eugenol, cineol, nutmeg The own rouge of sour isopropyl propionate, isopropyl palmitate fat, palm acid ethyl, white pond flower lactone, betulin, bisabolol, sandalwood oil, sesame Flaxseed oil, ginseng seed oil, levisticum officinale seed oil, in rosemary leaf oil, thyme caul-fat, frankincense oil, linolenic acid, evening primrose oil The mixture of any one or more.

Embodiment 21

In the embodiment of the present invention, a kind of trichogenous composition, including following raw material by weight: Radix Stephaniae Tetrandrae 50 parts of alkali, 60 parts of cyclic adenosine monophosphate, 0.1 part of ciclosporin A, 20 parts of Bimatoprost, 350 parts of Fullerol, 30 parts of panthenol.

The trichogenous composition further includes the moisturizer that mass concentration is 0.1%；Moisturizer be glycerol, Natrulon H-10,20 carbon of Natrulon H-10, two acid esters/14 carbon, two esters of gallic acid, Natrulon H-10 dioleate, Natrulon H-10 meat Myristate, Natrulon H-10 diisopstearate, propylene glycol, polypropylene glycol, Aloe Vera Gel, sodium chondroitin sulfate, deer-bone collagenous egg White, Sodium Hyaluronate, threonine, citrulling, alanine, polyglutamic acid sodium, methionine, leucine, creatine, the sweet ammonia of glycyl Acid, tremella polysaccharides, panaxan, Radix Angelicae Sinensis polysaccharide, the mixture of any one or more in astragalus polyose.

The kenel of the product can be lotion, shampoo, washing lotion, creme, spray, gel, liniment tincture, solution, Aerosol, plastics, patch, film, one of paste, ointment and paste.

Embodiment 22

In the embodiment of the present invention, a kind of trichogenous composition, including following raw material by weight: Radix Stephaniae Tetrandrae 55 parts of alkali, 25 parts of cyclic adenosine monophosphate, 60 parts of Bimatoprost, 100 parts of ciclosporin A, 2 parts of Fullerol, 75 parts of panthenol.

The trichogenous composition further includes the moisturizer that mass concentration is 8%；Moisturizer is glycerol, gathers Glycerol -10,20 carbon of Natrulon H-10, two acid esters/14 carbon, two esters of gallic acid, Natrulon H-10 dioleate, Natrulon H-10 Pork and beans Cool acid esters, Natrulon H-10 diisopstearate, propylene glycol, polypropylene glycol, Aloe Vera Gel, sodium chondroitin sulfate, deer-bone collagenous egg White, Sodium Hyaluronate, threonine, citrulling, alanine, polyglutamic acid sodium, methionine, leucine, creatine, the sweet ammonia of glycyl Acid, tremella polysaccharides, panaxan, Radix Angelicae Sinensis polysaccharide, the mixture of any one or more in astragalus polyose.

Embodiment 23

In the embodiment of the present invention, a kind of trichogenous composition, including following raw material by weight: Radix Stephaniae Tetrandrae 75 parts of alkali, 35 parts of cyclic adenosine monophosphate, 40 parts of Bimatoprost, 50 parts of ciclosporin A, 3 parts of Fullerol, 35 parts of panthenol.

The trichogenous composition further includes the moisturizer that mass concentration is 4%；Moisturizer is glycerol, gathers Glycerol -10,20 carbon of Natrulon H-10, two acid esters/14 carbon, two esters of gallic acid, Natrulon H-10 dioleate, Natrulon H-10 Pork and beans Cool acid esters, Natrulon H-10 diisopstearate, propylene glycol, polypropylene glycol, Aloe Vera Gel, sodium chondroitin sulfate, deer-bone collagenous egg White, Sodium Hyaluronate, threonine, citrulling, alanine, polyglutamic acid sodium, methionine, leucine, creatine, the sweet ammonia of glycyl Acid, tremella polysaccharides, panaxan, Radix Angelicae Sinensis polysaccharide, the mixture of any one or more in astragalus polyose.

Embodiment 24

In the embodiment of the present invention, a kind of trichogenous composition, including following raw material by weight: Radix Stephaniae Tetrandrae 8 parts of alkali, 8 parts of cyclic adenosine monophosphate, 40 parts of Bimatoprost, 20 parts of ciclosporin A, 250 parts of Fullerol, 55 parts of panthenol.

The trichogenous composition further includes polyalcohols/Polyphenols anti-corrosion that mass concentration is 0.01% Agent；Polyalcohols/Polyphenols preservative is Phenoxyethanol, in 1,2- pentanediol, pungent glycol, chamenol, Kaempferol, Paeonol The mixture of any one or more.

Embodiment 25

In the embodiment of the present invention, a kind of trichogenous composition, including following raw material by weight: Radix Stephaniae Tetrandrae 12 parts of alkali, 35 parts of cyclic adenosine monophosphate, 15 parts of Bimatoprost, 40 parts of ciclosporin A, 3 parts of Fullerol, 85 parts of panthenol.

The trichogenous composition further includes polyalcohols/Polyphenols preservative that mass concentration is 5%； Polyalcohols/Polyphenols preservative is Phenoxyethanol, 1,2- pentanediol, pungent glycol, chamenol, Kaempferol, appointing in Paeonol It anticipates one or more mixtures.

Embodiment 26

In the embodiment of the present invention, a kind of trichogenous composition, including following raw material by weight: Radix Stephaniae Tetrandrae 65 parts of alkali, 12 parts of cyclic adenosine monophosphate, 2 parts of Bimatoprost, 80 parts of ciclosporin A, 250 parts of Fullerol, 60 parts of panthenol.

The trichogenous composition further includes polyalcohols/Polyphenols preservative that mass concentration is 2%； Polyalcohols/Polyphenols preservative is Phenoxyethanol, 1,2- pentanediol, pungent glycol, chamenol, Kaempferol, appointing in Paeonol It anticipates one or more mixtures.

Embodiment 27

In the embodiment of the present invention, a kind of trichogenous composition, including following raw material by weight: Radix Stephaniae Tetrandrae 30 parts of alkali, 60 parts of cyclic adenosine monophosphate, 250 parts of Bimatoprost, 5 parts of ciclosporin A, 250 parts of Fullerol, 55 parts of panthenol.

The trichogenous composition further includes the comprehensive reagent that mass concentration is 0.01%；Comprehensive examination Agent is 1,2- hexylene glycol, Sensiva SC50, propylene glycol/10- hydroxydecanoic acid, aurantiamarin methyl chalcone, zinc glycyrrhizate, ketone health Azoles, VitAVitE, tea oil, benzalkonium chloride, chlorogenic acid, lipoic acid, cytidine, DNA, adenosine phosphate, cytimidine, gland Glycosides, phytosterol, choline, vitamin B6, vitamin B3, folic acid, niacinamide, Chrysin, oleanolic acid, asparagine, biology Element, theophylline, capsaicine, quinin hydrochloride, hydrolysis sesame protein, hydrolysis placenta (sheep) extract, ginkegetin, taurine, coffee The mixture of any one or more of coffee because in.

Embodiment 28

In the embodiment of the present invention, a kind of trichogenous composition, including following raw material by weight: Radix Stephaniae Tetrandrae 36 parts of alkali, 48 parts of cyclic adenosine monophosphate, 250 parts of Bimatoprost, 1 part of ciclosporin A, 48 parts of Fullerol, 60 parts of panthenol.

The trichogenous composition further includes that the anti-microbial type that mass concentration is 3% maintains the comprehensive of stable components Conjunction property reagent；Comprehensive reagent is 1,2- hexylene glycol, Sensiva SC50, propylene glycol/10- hydroxydecanoic acid, aurantiamarin methyl are looked into Your ketone, zinc glycyrrhizate, ketoconazole, VitAVitE, tea oil, benzalkonium chloride, chlorogenic acid, lipoic acid, cytidine, DNA, Adenosine phosphate, cytimidine, adenosine, phytosterol, choline, vitamin B6, vitamin B3, folic acid, niacinamide, Chrysin, Qi Dun Tartaric acid, asparagine, biotin, theophylline, capsaicine, quinin hydrochloride, hydrolysis sesame protein, hydrolysis placenta (sheep) extract, silver Ginkgetin, the mixture of any one or more in taurine, caffeine.

Embodiment 29

In the embodiment of the present invention, a kind of trichogenous composition, including following raw material by weight: Radix Stephaniae Tetrandrae 72 parts of alkali, 25 parts of cyclic adenosine monophosphate, 3 parts of Bimatoprost, 10 parts of ciclosporin A, 80 parts of Fullerol, 40 parts of panthenol.

The trichogenous composition further includes that the anti-microbial type that mass concentration is 1% maintains the comprehensive of stable components Conjunction property reagent；Comprehensive reagent is 1,2- hexylene glycol, Sensiva SC50, propylene glycol/10- hydroxydecanoic acid, aurantiamarin methyl are looked into Your ketone, zinc glycyrrhizate, ketoconazole, VitAVitE, tea oil, benzalkonium chloride, chlorogenic acid, lipoic acid, cytidine, DNA, Adenosine phosphate, cytimidine, adenosine, phytosterol, choline, vitamin B6, vitamin B3, folic acid, niacinamide, Chrysin, Qi Dun Tartaric acid, asparagine, biotin, theophylline, capsaicine, quinin hydrochloride, hydrolysis sesame protein, hydrolysis placenta (sheep) extract, silver Ginkgetin, the mixture of any one or more in taurine, caffeine.

Embodiment 30

In the embodiment of the present invention, a kind of trichogenous composition, including following raw material by weight: Radix Stephaniae Tetrandrae 5 parts of alkali, 95 parts of cyclic adenosine monophosphate, 1 part of Bimatoprost, 2 parts of ciclosporin A, 450 parts of Fullerol, 30 parts of panthenol.

The trichogenous composition further includes that the pH adjusting agent that mass concentration is 0.1-3% and/or quality are dense The emulsifier that the tackifier and/or mass concentration that degree is 0-2% are 0-5%；PH adjusting agent is arginine, sodium bicarbonate, carbonic acid Hydrogen potassium, dipotassium hydrogen phosphate, potassium hydrogen phosphate, lactic acid, salicylic acid, aspartic acid, one of pyroglutamic acid, malic acid, citric acid Or a variety of mixture；The pH value of composition is 4.0；Tackifier are Sodium Hyaluronate, xanthan gum, cellulose family, carbomer, bright One of glue or a variety of mixtures.

The tackifier preferably clear matter acid sodium and xanthan gum.

Embodiment 31

In the embodiment of the present invention, a kind of trichogenous composition, including following raw material by weight: Radix Stephaniae Tetrandrae 2.5 parts of alkali, 18 parts of cyclic adenosine monophosphate, 0.3 part of Bimatoprost, 30 parts of ciclosporin A, -1720 parts of myristoyl pentapeptide, richness Strangle 8 parts of alcohol, 35 parts of panthenol.

The trichogenous composition further includes that the pH adjusting agent that mass concentration is 0.1-3% and/or quality are dense The emulsifier that the tackifier and/or mass concentration that degree is 0-2% are 0-5%；PH adjusting agent is arginine, sodium bicarbonate, carbonic acid Hydrogen potassium, dipotassium hydrogen phosphate, potassium hydrogen phosphate, lactic acid, salicylic acid, aspartic acid, one of pyroglutamic acid, malic acid, citric acid Or a variety of mixture；The pH value of composition is 8.0；Tackifier are Sodium Hyaluronate, xanthan gum, cellulose family, carbomer, bright One of glue or a variety of mixtures.

The tackifier preferably clear matter acid sodium and xanthan gum.

Embodiment 32

In the embodiment of the present invention, a kind of trichogenous composition, including following raw material by weight: Radix Stephaniae Tetrandrae Alkali part, 40 parts of cyclic adenosine monophosphate, 0.1 part of Bimatoprost, -160.1 parts of myristoyl hexapeptide, 20 parts of Fullerol, panthenol 80 Part.

The trichogenous composition further includes that the pH adjusting agent that mass concentration is 0.1-3% and/or quality are dense The emulsifier that the tackifier and/or mass concentration that degree is 0-2% are 0-5%；PH adjusting agent is arginine, sodium bicarbonate, carbonic acid Hydrogen potassium, dipotassium hydrogen phosphate, potassium hydrogen phosphate, lactic acid, salicylic acid, aspartic acid, one of pyroglutamic acid, malic acid, citric acid Or a variety of mixture；The pH value of composition is preferably 6.0；Tackifier are Sodium Hyaluronate, xanthan gum, cellulose family, card wave One of nurse, gelatin or a variety of mixtures.

The tackifier preferably clear matter acid sodium or xanthan gum.

Embodiment 33

In the embodiment of the present invention, a kind of trichogenous composition, including following raw material by weight: Radix Stephaniae Tetrandrae 30 parts of alkali, 40 parts of cyclic adenosine monophosphate, 0.1 part of ciclosporin A, 90 parts of Fullerol, 80 parts of panthenol.

Embodiment 34

In the embodiment of the present invention, a kind of trichogenous composition, including following raw material by weight: Radix Stephaniae Tetrandrae 12 parts of alkali, 35 parts of cyclic adenosine monophosphate, 50 parts of minoxidil, 40 parts of ciclosporin A, 3 parts of Fullerol, 85 parts of panthenol.

Embodiment 35

In the embodiment of the present invention, a kind of trichogenous composition, including following raw material by weight: Radix Stephaniae Tetrandrae 65 parts of alkali, 12 parts of cyclic adenosine monophosphate, 200 parts of minoxidil, 80 parts of ciclosporin A, 250 parts of Fullerol, 60 parts of panthenol.

Embodiment 36

In the embodiment of the present invention, a kind of trichogenous composition, including following raw material by weight: Radix Stephaniae Tetrandrae 30 parts of alkali, 60 parts of cyclic adenosine monophosphate, 500 parts of minoxidil, 5 parts of ciclosporin A, 250 parts of Fullerol, 55 parts of panthenol.

Embodiment 37

In the embodiment of the present invention, a kind of trichogenous composition, including following raw material by weight: Radix Stephaniae Tetrandrae 36 parts of alkali, 48 parts of cyclic adenosine monophosphate, 300 parts of minoxidil, 250 parts of Bimatoprost, 1 part of ciclosporin A, 48 parts of Fullerol, 60 parts of panthenol.

Embodiment 38

In the embodiment of the present invention, a kind of trichogenous composition, including following raw material by weight: Radix Stephaniae Tetrandrae 72 parts of alkali, 25 parts of cyclic adenosine monophosphate, 100 parts of minoxidil, 3 parts of Bimatoprost, -170.1 parts of myristoyl pentapeptide, ring spore 10 parts of plain A, 80 parts of Fullerol, 40 parts of panthenol.

Embodiment 39

In the embodiment of the present invention, a kind of trichogenous composition, including following raw material by weight: Radix Stephaniae Tetrandrae 5 parts of alkali, 95 parts of cyclic adenosine monophosphate, -1750 parts of myristoyl pentapeptide, 1 part of Bimatoprost, 2 parts of ciclosporin A, Fullerol 450 parts, 30 parts of panthenol.

The tackifier preferably clear matter acid sodium and xanthan gum.

Embodiment 40

In the embodiment of the present invention, a kind of trichogenous composition, including following raw material by weight: Radix Stephaniae Tetrandrae 2.5 parts of alkali, 18 parts of cyclic adenosine monophosphate, -1610 parts of myristoyl hexapeptide, 0.3 part of Bimatoprost, 30 parts of ciclosporin A, meat - 1720 parts of myristoyl pentapeptide, 8 parts of Fullerol, 35 parts of panthenol.

The tackifier preferably clear matter acid sodium and xanthan gum.

Comparative example 1

2% minoxidil solution.

Comparative example 2

0.03% Bimatoprost solution.

It coats and the promotion that mouse hair is grown is tested:

It will carry out the mouse after depilation modeling and be divided into 20 groups, every group 40, lose hair or feathers from second day respectively at mouse after modeling Lotion made of composition described in area smearing embodiment 1-17, comparative example 1, comparative example 2, blank group are not smeared any Drug is twice daily persistently smeared 3 days.From after coating the 2nd day, the variation of observation mouse hair removal section skin color determined hair The growth conditions of capsule, recording mouse skin respectively becomes the number of days of black and becomes the time of grey black, calculates mouse skin and becomes Black continuous days.The number of days that mouse skin becomes black is shorter, it was demonstrated that trichogenous speed is faster, and effect is better；It is small It is longer that mouse skin becomes the lasting number of days of black, it was demonstrated that promotes hair growth duration longer, effect is better.

Learnt by the above test result, comparative example 1 and comparative example 2 compare blank group have it is certain raw to hair Long facilitation effect, but compared to lotion made of composition described in 1-17 of the embodiment of the present invention to trichogenous effect Either the speed of hair growth or hair duration for becoming black, 1-17 of the embodiment of the present invention are significantly better than that comparison Embodiment 1 is 2% minoxidil solution and comparative example 2 is 0.03% Bimatoprost.

It is obvious to a person skilled in the art that invention is not limited to the details of the above exemplary embodiments, Er Qie In the case where without departing substantially from spirit or essential attributes of the invention, the present invention can be realized in other specific forms.Therefore, no matter From the point of view of which point, the present embodiments are to be considered as illustrative and not restrictive, and the scope of the present invention is by appended power Benefit requires rather than above description limits, it is intended that all by what is fallen within the meaning and scope of the equivalent elements of the claims Variation is included within the present invention.

In addition, it should be understood that although this specification is described in terms of embodiments, but not each embodiment is only wrapped Containing an independent technical solution, this description of the specification is merely for the sake of clarity, and those skilled in the art should It considers the specification as a whole, the technical solutions in the various embodiments may also be suitably combined, forms those skilled in the art The other embodiments being understood that.

Claims

1. a kind of trichogenous composition, which is characterized in that including Tetrandrine, cyclic adenosine monophosphate, Fullerol and general Alcohol.

2. a kind of trichogenous composition according to claim 1, which is characterized in that according to the mass fraction, packet Include 1-100 parts of Tetrandrine, 1-100 parts of cyclic adenosine monophosphate, 1-500 parts of Fullerol, 10-100 parts of panthenol.

3. a kind of trichogenous composition according to claim 2, which is characterized in that according to the mass fraction, institute State trichogenous composition further include 0.1-300 parts of 0.1-100 parts of ciclosporin A and/or Bimatoprost and/or 50-500 parts of minoxidil.

4. a kind of trichogenous composition according to claim 2, which is characterized in that according to the mass fraction, institute Stating trichogenous composition further includes -17 0.1-100 parts of myristoyl pentapeptide and/or myristoyl hexapeptide -16 0.1-100 parts.

5. a kind of trichogenous composition according to claim 3, which is characterized in that according to the mass fraction, institute Stating trichogenous composition further includes -17 0.1-100 parts of myristoyl pentapeptide and/or myristoyl hexapeptide -16 0.1-100 parts.

6. a kind of trichogenous composition according to claim 1-5, which is characterized in that the promotion The composition of hair growth further includes the penetration enhancer that mass concentration is 0.1-8%

And/or mass concentration is the moisturizer of 0.1-8%

And/or mass concentration is polyalcohols/Polyphenols preservative of 0.01-3%

And/or mass concentration is the comprehensive reagent of 0.01-8%.

7. a kind of trichogenous composition according to claim 6, which is characterized in that

The penetration enhancer be ethyl alcohol, propylene glycol, oleyl alcohol, benzyl carbinol, Laurocapram, limonene, nerol, menthol, Eugenol, cineol, myristic acid isopropyl propionate, isopropyl palmitate fat, the own rouge of palm acid ethyl, white pond flower lactone, white birch ester Alcohol, bisabolol, sandalwood oil, sesame seed oil, ginseng seed oil, levisticum officinale seed oil, rosemary leaf oil, thyme caul-fat, olibanum Oil, linolenic acid, the mixture of any one or more in evening primrose oil；

The moisturizer is glycerol, Natrulon H-10,20 carbon of Natrulon H-10, two acid esters/14 carbon, two esters of gallic acid, Natrulon H-10 It is dioleate, Natrulon H-10 myristinate, Natrulon H-10 diisopstearate, propylene glycol, polypropylene glycol, Aloe Vera Gel, soft It is ossein sodium sulphate, deer-bone collagenous albumen, Sodium Hyaluronate, threonine, citrulling, alanine, polyglutamic acid sodium, methionine, bright Propylhomoserin, creatine, glycylglycine, tremella polysaccharides, panaxan, Radix Angelicae Sinensis polysaccharide, any one or more in astragalus polyose Mixture；

The polyalcohols/Polyphenols preservative is Phenoxyethanol, 1,2- pentanediol, pungent glycol, chamenol, Kaempferol, the root bark of tree peony The mixture of any one or more in phenol；

The comprehensive reagent is 1,2- hexylene glycol, Sensiva SC50, propylene glycol/10- hydroxydecanoic acid, aurantiamarin methyl Cha Er Ketone, zinc glycyrrhizate, ketoconazole, VitAVitE, tea oil, benzalkonium chloride, chlorogenic acid, lipoic acid, cytidine, DNA, phosphorus Adenosine monophosphate, cytimidine, adenosine, phytosterol, choline, vitamin B6, vitamin B3, folic acid, niacinamide, Chrysin, olive Acid, asparagine, biotin, theophylline, capsaicine, quinin hydrochloride, hydrolysis sesame protein, hydrolysis placenta (sheep) extract, ginkgo Biflavone, taurine, the mixture of any one or more in caffeine.

8. a kind of trichogenous composition according to claim 1, which is characterized in that the promotion hair growth Composition further include the pH adjusting agent that mass concentration is 0.1-3% and/or tackifier and/or matter that mass concentration is 0-2% Measure the emulsifier that concentration is 0-5%；

The pH adjusting agent is arginine, sodium bicarbonate, saleratus, dipotassium hydrogen phosphate, potassium hydrogen phosphate, lactic acid, salicylic acid, day Aspartic acid, one of pyroglutamic acid, malic acid, citric acid or a variety of mixtures；

The tackifier are one of Sodium Hyaluronate, xanthan gum, cellulose, carbomer, gelatin or a variety of mixtures.

9. a kind of trichogenous composition according to claim 1, which is characterized in that the promotion hair growth Composition pH value range be 4.0~8.0.

10. a kind of -9 any trichogenous compositions according to claim 1 promote hair growth to produce in preparation Application in product.