CN110193017A - A kind of spray-filming agent and preparation method thereof promoting hair growth - Google Patents
A kind of spray-filming agent and preparation method thereof promoting hair growth Download PDFInfo
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- CN110193017A CN110193017A CN201910446155.0A CN201910446155A CN110193017A CN 110193017 A CN110193017 A CN 110193017A CN 201910446155 A CN201910446155 A CN 201910446155A CN 110193017 A CN110193017 A CN 110193017A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
- A61K31/5575—Eicosanoids, e.g. leukotrienes or prostaglandins having a cyclopentane, e.g. prostaglandin E2, prostaglandin F2-alpha
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/46—Ingredients of undetermined constitution or reaction products thereof, e.g. skin, bone, milk, cotton fibre, eggshell, oxgall or plant extracts
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7015—Drug-containing film-forming compositions, e.g. spray-on
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
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Abstract
The invention belongs to technical field of medicine, and in particular to a kind of spray-filming agent and preparation method thereof for promoting hair growth.The spray-filming agent, as mass fraction, including following component: Bimatoprost 0.01%~0.05%, ginger extract 0.05%~0.2%, ethyl alcohol 10%~50%, film forming agent 0.01%~8%, plasticizer 0.1%~0.8%, penetrating agent 0.02%~2%, pH buffer 0.01%~3%, surplus are water for injection；The pH value of the spray-filming agent is 6.5~7.5；The present invention also provides a kind of methods for preparing the spray-filming agent for promoting hair growth.The spray-filming agent of rush hair growth of the invention forms visible or sightless transparent and homogeneous medicine film in medication, and while being administered continuously, the insulation blocking surface of a wound is not only easy to use, but also its bioavilability can be improved, and has good potential applicability in clinical practice.
Description
Technical field
The invention belongs to technical field of medicine, and in particular to it is a kind of promote hair growth spray-filming agent and its preparation side
Method.
Background technique
Alopecia is commonplace phenomenon, and is more common in male adults.Androgenetic alopecia (AGA) is most common
Alopecia type, illness rate is up to 61% in Chinese population.Serious alopecia is often considered as the performance of body aging, hypofunction,
Reduce patient to the satisfaction of self-image, self-doubt, pressure, pain sensation increase, increase with the concern that the age increases, because
The serious hope of this patient for treatment subsist benefit increase.Alopecia is prevented there are many method in the market or promotes hair restoration, but nearly all
There is side effect, or just loses effect after being discontinued.
Bimatoprost is initially with eye drop form for treating glaucoma, and discovery can promote ciliogensis in clinical application
It is long.Later, FDA was used for eyelash growing liquid, this cosmetic formulations formula of Bimatoprost in approval Bimatoprost in 2008
With the sale of Latisse trade name.Now, it was discovered by researchers that Bimatoprost can increase culture in pharmacology selective concentrations
Hair on number of people skin in hair follicle generates and the regeneration of mouse fur.This discovery can guide Bimatoprost for treating male
Alopecia improves the quality of life of exiguous human hair person.
Bimatoprost can also promote alopecia director to go out new hair in addition to for treating glaucoma, promotion eyelashes are grown,
Approved is used in eye drops, and eyelash growing liquid, it is logical that securely and reliably, but eye drops or eyelash growing liquid, which are all true solutions,
The mode for crossing drops and smearing uses, and is all inconvenient to treat head alopecia use.In addition Bimatoprost expensive raw material price is come
Source is rare, carries out hair growth with the medicament drops of Bimatoprost or smearing, certainly will will cause high amount of drug waste, biology benefit
Expenditure is lower.Therefore, it is necessary to develop more suitably, for hair growth, there is the Bei Meiqian compared with high bioavilability
Arrange effective preparation of element.
Summary of the invention
Preparation bioavilability in order to solve the problems, such as hair growth in the prior art is low and wastage of material, of the invention
It is designed to provide a kind of Bimatoprost spray-filming agent and preparation method thereof for promoting hair growth, to improve the life of Bimatoprost
Object availability.
Spray-filming agent provided by the invention, easy to use, medical fluid need to be only sprayed on by user needs long hair position, solvent volatilization,
In conjunction with the thermo-sensitive gel characteristic of the poloxamer in spray-filming agent, the almost invisible medicine of thin layer naked eyes will soon be formed
Film.
The present invention is achieved through the following technical solutions:
A kind of spray-filming agent promoting hair growth, as mass fraction, including following component: Bimatoprost 0.01%~
0.05%, ginger extract 0.05%~0.2%, ethyl alcohol 10%~50%, film forming agent 0.01%~8%, plasticizer 0.1%~
0.8%, penetrating agent 0.02%~2%, pH buffer 0.01%~3% and other auxiliary materials 0~1%, surplus are water for injection；Institute
The pH value for stating spray-filming agent is 6.5~7.5.
Preferably, as mass fraction, including following component: Bimatoprost 0.01%~0.04%, ginger extract
0.07%~0.2%, ethyl alcohol 20%~40%, film forming agent 0.01%~6%, plasticizer 0.3%~0.6%, penetrating agent
0.02%~1%, pH buffer 0.07%~2.5% and other auxiliary materials 0~0.1%.
The present invention adds ethyl alcohol and additionally aids ginger extract and Bei Mei while improving Bimatoprost solubility
The mixing of forefront element and unclassified stores；When spray-filming agent film forming, volatilization is fast, is conducive to film forming.
Preferably, the film forming agent is poloxamer, medical chitose, polyvinyl alcohol, crospovidone, hypromellose
One of element or any several combinations.
It is highly preferred that the film forming agent is the combination of poloxamer, medical chitose and polyvinyl alcohol；Poloxamer, tool
There is the characteristic of temperature-sensitive sol-gel transition, low temperature is liquid, it is in soft gel when close to body temperature, plays fabulous filming function,
And it is good with skin-friendliness, promote the absorption of topical agent, medical chitose has bacteriostasis, can play corrosion-resistant effect
Fruit, and medical chitose is used in combination with poloxamer, it will promote the film forming of poloxamer, accelerate film forming speed, increases
The adhesiveness of film improves the bioavilability of drug so that contained drug ingedient is effectively secured in film.
Preferably, the ginger extract is to be obtained by soxhlet extraction, specifically: by ginger chip drying powder
It is broken, ginger powder is obtained, the ethanol water of 75wt% is added into ginger powder, extracts 2 hours and obtains by Soxhlet extractor, this
The purity and yield for the ginger extract that kind method is extracted are higher, the volume ratio of the ethanol water of the ginger powder and 75wt%
For 1:7, ginger has the effect of inducing diaphoresis, diverging, and external application ginger can increase head blood circulation, and hair follicle stimulating is opened, and the present invention adds
The Ginger P.E added can expand the blood vessel of scalp tissue, increase local circulation, keep hair follicle more vibrant, accelerate Bei Meiqian
Column element is absorbed and utilized.
Preferably, the plasticizer is one of glycerol, polyethylene glycol and propylene glycol or any several combinations.
Preferably, the penetrating agent is one of borneol, menthol and peppermint oil or any several combinations, institute of the present invention
Addition penetrating agent can promote effective absorption of drug.
Preferably, the pH buffer includes in sodium hydroxide or/and hydrochloric acid, citrate, borate and phosphate
One or any of several combines, and the pH value of the spray-filming agent in the present invention is controlled in 6.5-7.5.
Preferably, other described auxiliary materials are the combination of one or more of vitamin E, glycerol and essence, and the dimension of addition is raw
Plain E and glycerol play the role of nourishing scalp, improve the curative effect of drug.
For spray-filming agent, it is necessary to assure medical fluid can smoothly be sprayed from spray bottle, and droplet is uniform, usual situation,
It is certain spraying apart from inner, medicine liquid spray area is bigger, and droplet is thinner, and the film formed after spraying is more uniform, in addition, film formation time is not
It is preferably too long.
The present invention is index with medicine liquid spray area, film formation time, the uniformity of film, is screened by a large number of experiments into membrane material
Material, auxiliary material and respective proportion, and obtain the preparation method of following trichogenous spray-filming agent:
(1) main ingredient dissolves: preparing pH buffer, Bimatoprost is added in ethyl alcohol, then ginger is added in stirring and dissolving
Extracting solution is then added in pH buffer, obtains the mixed solution containing main ingredient；
(2) medical fluid mixes: film forming agent, plasticizer, penetrating agent and other auxiliary materials being added in Xiang Shangshu mixed solution, note is added
It penetrates and uses water constant volume, dissolution forms medical fluid；
(3) degerming is filling: above-mentioned medical fluid being passed through 0.22 μm of membrane filtration degerming, and aseptically filling to spraying
The spray-filming agent of rush hair growth is arrived in agent bottle.
Beneficial effects of the present invention:
(1) spray-filming agent prepared by the present invention is a kind of combination film, spray and patch advantage in the Novel external of one
Film forming liquid medicine quantitative is sprayed on affected part using medicinal spray bottle, forms visible or sightless transparent and homogeneous medicine film by form of administration,
While being administered continuously, the insulation blocking surface of a wound is not only easy to use, but also its bioavilability can be improved, and avoids simultaneously
The greasy feeling of ointment medicament.
(2) the Bimatoprost spray-filming agent prepared by the present invention for promoting hair growth, by the way that poloxamer and chitosan is added
Collaboration use, chitosan will promote the film forming of poloxamer, accelerate film forming speed, increase the adhesiveness of film, so that contained
Drug ingedient be effectively secured in film, the bioavilability of drug is improved, in other preparations compared with the existing technology
Drug effect, the concentration (0.01 of the added Bimatoprost of spray-filming agent of the invention are improved by improving the concentration of Bimatoprost
~0.05wt%) it is greatly reduced compared with the prior art, cost greatlys save.
(3) spray-filming agent simple process, strong operability are conducive to promote the use of, and are equipped with other ingredients for being conducive to hair tonic, then can be with
Achieve the effect that get twice the result with half the effort, there is good potential applicability in clinical practice.
Specific embodiment
Experimental method in following embodiment is conventional method unless otherwise required, related experiment reagent and material
Material is conventional biochemical reagent and material unless otherwise required.
One, promote the preparation of the spray-filming agent of hair growth
Embodiment 1
Prescription: by taking 10000mL spray-filming agent as an example
Preparation method:
Recipe quantity boric acid and borax are added into 6000mL water for injection, after being completely dissolved, the pH that pH value is 6.8 is obtained and buffers
Agent is heated to 70 DEG C, and hydroxypropyl methylcellulose is added and is evenly stirred until that temperature is cooled to 25 DEG C, as mixed solution 1, the forefront Bei Mei
Element is added to stirring and dissolving in ethyl alcohol, adds ginger extract, stirs evenly, as mixed solution 2；Mixed solution 2 is added
It is uniformly mixed into mixed solution 1, then is sequentially added into poloxamer, polyvinyl alcohol, medical chitose, glycerol, menthol,
Vitamin E is settled to 10000mL with water for injection.It stirs evenly, passes through 0.22 μm of membrane filtration degerming, every bottle of 100mL packing
Promote the spray-filming agent of hair growth to get 100 into aerosol container.
Embodiment 2
Prescription: by taking 10000mL spray-filming agent as an example
Preparation method:
Recipe quantity potassium dihydrogen phosphate is added into 4000mL water for injection, after being completely dissolved, the sodium hydroxide that 1mol/L is added is molten
Liquid adjusts pH value to 6.7, obtains phosphate pH buffer, as mixed solution 1, Bimatoprost be added in ethyl alcohol stir it is molten
Solution, is then added ginger extract, stirs evenly, as mixed solution 2；Mixed solution 2 is added to be mixed into mixed solution 1
Even, then be sequentially added into poloxamer, polyvinyl alcohol, medical chitose, glycerol, borneol, vitamin E is fixed with water for injection
Hold to 10000mL.It stirs evenly, by 0.22 μm of membrane filtration degerming, every bottle of 200mL is dispensed into aerosol container to get 50
The spray-filming agent of branch rush hair growth.
Embodiment 3
Prescription: by taking 10000mL spray-filming agent as an example
Preparation method:
Recipe quantity citric acid is added into 6000ml water for injection, after being completely dissolved, adjusts pH with 50wt% sodium hydroxide solution
Value obtains citrate pH buffer, is heated to 70 DEG C, hydroxypropyl methylcellulose is added and is evenly stirred until that temperature is cooled to 25 to 6.6
DEG C, as mixed solution 1, Bimatoprost is added to stirring and dissolving in ethyl alcohol, and ginger extract is then added, it stirs evenly,
As mixed solution 2；Mixed solution 2 is added to be uniformly mixed into mixed solution 1, then is sequentially added into poloxamer, poly- second
Enol, medical chitose, propylene glycol, peppermint oil, vitamin E are settled to 10000ml with water for injection.It stirs evenly, passes through
0.22 μm of membrane filtration degerming, every bottle of 200ml dispense into aerosol container the spray-filming agent for promoting hair growth to get 50.
Embodiment 4
Prescription: by taking 10000mL spray-filming agent as an example
Preparation method:
Recipe quantity disodium hydrogen phosphate is added into 6000mL water for injection, after being completely dissolved, with 1mol/L hydrochloric acid solution
PH value is adjusted to 6.7, obtains phosphate pH buffer, as mixed solution 1, Bimatoprost is added to stirring and dissolving in ethyl alcohol,
Then ginger extract is added, stirs evenly as mixed solution 2；Mixed solution 2 is added to be uniformly mixed into mixed solution 1,
It is sequentially added into poloxamer again, polyvinyl alcohol, medical chitose, glycerol, borneol, vitamin E is settled to water for injection
10000mL.It stirs evenly, by 0.22 μm of membrane filtration degerming, every bottle of 100mL is dispensed into aerosol container to be promoted to get 100
The spray-filming agent of hair growth.
Comparative example 1
Medical chitose in 1 prescription of embodiment is omitted, the preparation method is the same as that of Example 1 to get rush hair growth is arrived
Spray-filming agent.
Two, film properties test is sprayed
Investigate the spray film uniformity, the spray-filming agent of rush hair growth prepared by Example 1~4 and comparative example 1, same spray
Position of the film sample away from paper matrix 15cm is 3 times spraying to paper matrix, and ruler measures diametral distance at edge clear, calculates spraying face
Product obtains average value, and paper matrix is placed in 35 DEG C, observes the uniformity of film formation time and film, the results are shown in Table 1:
Table 1
| Group | Sample | Spray area (cm2) | Film formation time (s) | The film uniformity |
| 1 | Embodiment 1 | 65.6 | 32 | Well |
| 2 | Embodiment 2 | 60.8 | 39 | Well |
| 3 | Embodiment 3 | 69.4 | 40 | Well |
| 4 | Embodiment 4 | 63.6 | 38 | Well |
| 5 | Comparative example 1 | 60.2 | 168 | Generally |
As can be seen from Table 1, spray-filming agent sample obtained by embodiment 1 to embodiment 4, it is spraying uniform, after medical fluid is overlying on paper matrix
It does not flow, and forms a film within 50 seconds, even film layer is transparent, and naked eyes are almost invisible, makes by spraying suitable for alopecia position
With；And 1 gained spray-filming agent sample of comparative example is long with respect to film formation time, and the uniformity of film is also general, this may be due to implementing
The medical chitose added in prescription in example 1~4 can promote the film forming of poloxamer, accelerate film forming speed, film is made to be not easy to flow
Dynamic, the corresponding membrane uniformity also improves.
Three, promote the effect test of hair growth spray-filming agent
Modeling: using SD male rat as experimental animal, totally 20, every group 5, be blank model group, embodiment 1 respectively
Group, 1 group of comparative example and normal blank group, first blank model group, example 1 group and 1 group of comparative example of rat are with 1mL methyltestosterone
Solution (methyltestosterone tablets of 5mg/ piece are made into the medical fluid of 15mg/ml with distilled water) and 0.2mL lard stomach-filling, normal blank group are given
Equal amount of distilled water is given, continues stomach-filling according to the method described above after modeling success.Marking area at back with marking pen is 2cmx2cm's
Hair in the region is shaved light by region, and example 1 group 1 spray-filming agent sample of embodiment sprays 2 times/day, and 1 group of comparative example is used comparison
1 spray-filming agent sample of example sprays 2 times/day, and blank model group sprays equal amount of distilled water, and normal blank group is without any processing, successive administration
30 days, respectively at 10 days, 20 days, 30 days observation hair growth situations, using " ten point system " as the scoring of hair growth result, 0
Finger is divided not grow, 10 points of fingers growths are complete.Usually whether observation medical fluid spraying area there are the symptoms such as redness.As a result shown in table 2:
Table 2
As can be seen from Table 2, for 1 spray-filming agent sample of embodiment to androgenic alopecia, trichogenous effect is aobvious
It writes, and the hair growth effect of 1 spray-filming agent sample of comparative example is poor with respect to 1 spray-filming agent of embodiment, it may be possible to due to medical chitin
The adhesiveness that sugar can promote poloxamer to form a film improves drug so that contained drug ingedient is effectively secured in film
Bioavilability, promote hair growth effect it is relatively good.The spraying area appearance of four groups of animals is normal, does not occur the thorn such as redness
Swash symptom, spraying uniform, medical fluid is overlying on skin surface completely.
Four, hypersensitive test compares
It by taking 1 spray-filming agent sample of embodiment as an example, is tested by Buehler, observation guinea pig skin contacts 1 spray-filming agent of embodiment
Allergic reaction after sample, the safety of preliminary assessment tested material.
Test method: selecting 30 males and 30 Female guinea pigs, and negative control group is respectively set, and test sample group is positive
Control group, every group has 10 male guinea pigs and 10 Female guinea pigs；Experimental stage is divided into two stages, and the first stage is sensitization
Phase: only, 1 spray-filming agent sample of embodiment is administered in test sample group to 0.9% sodium chloride injection 0.5mL/ of negative control group administration
Only, positive controls give 1wt%2 to 0.5mL/, 4- dinitrofluorobenzene 0.5ml/ only, in test the 1st, 8,15 day in guinea pig back
The same position repeat administration in left side, totally 3 times；Second stage is stimulating phase: (being tested within the 14th day after the last administration in the sensitization phase
29th day) it is administered on the right side of guinea pig back, positive controls give 0.2wt%2, and 4- dinitrofluorobenzene 0.5mL/ is only, negative right
It is identical as the sensitization phase according to the dosage of group and test sample group.
All animals carry out a Detailed clinical observation daily during test；Divide first time sensitization (test the 1st day), second
Secondary (test the 8th day) third time sensitization phase sensitization phase (test the 15th day), the stimulating phase same day (test the 29th day), according to observation
Evaluation of result animal skin sensitivity response situation calculates allergic reaction incidence, as shown in table 3:
Table 3
As seen from the results in Table 3, the spray-filming agent prepared by the present invention for promoting hair growth also has no to cavy without obvious sensitization
Other toxicity.
Five, limit test of microbe is tested
Spray-filming agent of the present invention is free of preservative, for investigate save during product microbial limit situation, with embodiment 1~
4 gained spray-filming agent sample detection microbial limits place condition: placing (25 DEG C ± 2 of condition with reference to Chinese Pharmacopoeia long-time stability
DEG C, humidity 60% ± 10%), respectively at the 0th, 3,6,9,12,18,24 month, sampling was examined according to 2015 editions Chinese Pharmacopoeia methods
Survey microbial limit, including aerobic bacteria sum, yeast and mold sum and control bacterium (escherichia coli, Staphylococcus aureus
Bacterium, pseudomonas aeruginosa) it checks.Aerobic bacteria sum, yeast and mold sum are recorded by count results, if control bacterium does not give birth to
It is long, it is indicated with "-", is indicated if growth with " ﹢ ".Inspection result is as shown in table 4:
Table 4
As can be seen from Table 4, the spray-filming agent prepared by the present invention for promoting hair growth places condition in long-time stability
Lower storage 2 years, microbial limit testing result is still qualified, and grows without any bacterium colony, it is believed that spray-filming agent of the present invention
Still there is good anti-corrosion effect at least 2 years.
Claims (10)
1. a kind of spray-filming agent for promoting hair growth, which is characterized in that as mass fraction, including following component: Bimatoprost
0.01%~0.05%, ginger extract 0.05%~0.2%, ethyl alcohol 10%~50%, film forming agent 0.01%~8%, plasticising
Agent 0.1%~0.8%, penetrating agent 0.02%~2%, pH buffer 0.01%~3%, surplus are water for injection；The spray film
The pH value of agent is 6.5~7.5.
2. a kind of spray-filming agent for promoting hair growth according to claim 1, which is characterized in that as mass fraction, including
Following component: Bimatoprost 0.01%~0.04%, ginger extract 0.07%~0.2%, ethyl alcohol 20%~40%, film forming
Agent 0.01%~6%, plasticizer 0.3%~0.6%, penetrating agent 0.02%~1%, pH buffer 0.07%~2.5%.
3. a kind of spray-filming agent for promoting hair growth according to claim 1, which is characterized in that the film forming agent is that pool Lip river is husky
One of nurse, medical chitose, polyvinyl alcohol, crospovidone, hydroxypropyl methylcellulose or any several combinations.
4. a kind of spray-filming agent for promoting hair growth according to claim 1, which is characterized in that the film forming agent is that pool Lip river is husky
The combination of nurse, medical chitose and polyvinyl alcohol.
5. a kind of spray-filming agent for promoting hair growth according to claim 1, which is characterized in that the ginger extract is
It is obtained by soxhlet extraction, specifically: ginger chip drying is crushed, ginger powder is obtained, 75wt% is added into ginger powder
Ethanol water, extract and obtain by Soxhlet extractor for 2 hours, the volume of the ethanol water of the ginger powder and 75wt%
Than for 1:7.
6. it is according to claim 1 it is a kind of promote hair growth spray-filming agent, which is characterized in that the plasticizer be glycerol,
One of polyethylene glycol and propylene glycol or any several combinations.
7. it is according to claim 1 it is a kind of promote hair growth spray-filming agent, which is characterized in that the penetrating agent be borneol,
One of menthol and peppermint oil or any several combinations.
8. a kind of spray-filming agent for promoting hair growth according to claim 1, which is characterized in that the pH buffer includes hydrogen
One of sodium oxide molybdena or/and hydrochloric acid, citrate, borate and phosphate or any several combinations.
9. a kind of spray-filming agent for promoting hair growth according to claim 1, which is characterized in that the spray-filming agent further includes it
His auxiliary material, other described auxiliary materials are the combination of one or more of vitamin E, glycerol and essence.
10. a kind of preparation method of the described in any item spray-filming agents for promoting hair growth of claim 1-9, which is characterized in that packet
Include following steps:
(1) main ingredient dissolves: preparing pH buffer, Bimatoprost is added in ethyl alcohol, stirring and dissolving, ginger is then added and extracts
Liquid is then added in pH buffer, obtains the mixed solution containing main ingredient；
(2) medical fluid mixes: film forming agent, plasticizer, penetrating agent and other auxiliary materials being added into the above-mentioned mixed solution containing main ingredient, add
Enter water for injection constant volume, dissolution forms medical fluid；
(3) degerming is filling: above-mentioned medical fluid being passed through 0.22 μm of membrane filtration degerming, and aseptically filling to aerosol container
In to get to promote hair growth spray-filming agent.
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| CN201910446155.0A CN110193017B (en) | 2019-05-27 | 2019-05-27 | Film spraying agent for promoting hair growth and preparation method thereof |
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| CN201910446155.0A CN110193017B (en) | 2019-05-27 | 2019-05-27 | Film spraying agent for promoting hair growth and preparation method thereof |
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| CN110193017B CN110193017B (en) | 2022-09-23 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115887421A (en) * | 2022-11-25 | 2023-04-04 | 上海市第一人民医院 | Compound glucocorticoid film spraying agent and preparation and application thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090123564A1 (en) * | 2006-03-31 | 2009-05-14 | Rajesh Jain | Novel compositions for hair disorders and process of preparation thereof |
| US20130078301A1 (en) * | 2009-12-31 | 2013-03-28 | Nnc Blending Llc | Methods for stimulating growth and preventing loss of human hair |
| CN109432400A (en) * | 2018-12-27 | 2019-03-08 | 深圳市福美富基因科技有限公司 | A kind of trichogenous composition and its application |
-
2019
- 2019-05-27 CN CN201910446155.0A patent/CN110193017B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090123564A1 (en) * | 2006-03-31 | 2009-05-14 | Rajesh Jain | Novel compositions for hair disorders and process of preparation thereof |
| US20130078301A1 (en) * | 2009-12-31 | 2013-03-28 | Nnc Blending Llc | Methods for stimulating growth and preventing loss of human hair |
| CN109432400A (en) * | 2018-12-27 | 2019-03-08 | 深圳市福美富基因科技有限公司 | A kind of trichogenous composition and its application |
Non-Patent Citations (1)
| Title |
|---|
| 汪雪君等: "喷膜剂的研究进展", 《生物加工过程》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115887421A (en) * | 2022-11-25 | 2023-04-04 | 上海市第一人民医院 | Compound glucocorticoid film spraying agent and preparation and application thereof |
| CN115887421B (en) * | 2022-11-25 | 2024-03-29 | 上海市第一人民医院 | Compound glucocorticoid spray film agent and preparation and application thereof |
Also Published As
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| CN110193017B (en) | 2022-09-23 |
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