CN112043627A

CN112043627A - Amino acid solution composition for hair growth and preparation method thereof

Info

Publication number: CN112043627A
Application number: CN202010919734.5A
Authority: CN
Inventors: 江一舟; 张思妍; 戴雅蓉; 温婕琪; 蒋心仪; 黄博轩; 凌荣崧; 黄文杰; 程轶凡
Original assignee: Gaoyanyuan Technology Shenzhen Co ltd
Current assignee: Gaoyanyuan Technology Shenzhen Co ltd
Priority date: 2020-09-04
Filing date: 2020-09-04
Publication date: 2020-12-08
Anticipated expiration: 2040-09-04
Also published as: CN112043627B

Abstract

The invention belongs to the technical field of hair growth, and particularly relates to an amino acid solution composition for promoting hair growth, improving sparse hair quantity and/or treating and/or preventing hair loss and a preparation method thereof. The composition consists of water-soluble substances, fat-soluble substances and liquid fluidity substances for regulating active ingredients, can permeate into a stratum corneum layer to ensure that the active ingredients enter hair follicles through smearing, regulate and control protein molecule signals for regulating the growth of hair follicle stem cells, reactivate the hair follicle stem cells, promote the hair follicles to enter a growth phase, promote the capillary blood increase of the hair follicles and further promote the hair growth.

Description

Amino acid solution composition for hair growth and preparation method thereof

Technical Field

The invention belongs to the technical field of hair growth, and particularly relates to an amino acid solution composition for promoting hair growth, improving sparse hair quantity and/or treating and/or preventing hair loss and a preparation method thereof.

Background

In many cultures, it is desirable to maintain a rich supply of hair in certain areas of the body, such as the hair, eyebrows, etc. Therefore, many hair growth products and techniques have been developed to promote hair growth.

There are 6-10 ten thousand adult scalp hair follicles. The growth of hair follicle is periodic, and divided into growth phase, catagen phase and resting phase. During the performance in the growth period, the growth is 0.2-0.4mm per day, the growth lasts for 2-7 years, and then the growth enters the regression period; in the catagen, hair follicles shrink and hair stops growing and is easy to fall off, generally 2-3 weeks, and then the catagen enters the telogen phase; the telogen phase lasts for 3-4 months and hair falls off until a new follicular cycle begins and enters a new anagen phase. The ratio of anagen to telogen phases of the hair follicles in the normal human scalp is 9/1. The cause of hair loss is an increased proportion of follicles in telogen phase, and even follicles that shrink, delay or fail to enter anagen phase. Hair follicle stem cells are important factors in maintaining the hair follicle cycle.

Androgenetic alopecia is the most common alopecia disease, the prevalence rate is obviously different among different races, the prevalence rate is the highest for caucasian people, and the prevalence rate is relatively low for caucasian and caucasian people. The latest data in China are displayed: the prevalence rate of male alopecia is about 21.3%, and the prevalence rate of female alopecia is about 6.0%. That is, one male in five countries suffers from alopecia. The data also show that the proportion of family genetic history in male patients is 53.3% -63.9%, and paternal inheritance is obviously higher than that of maternal inheritance. Other alopecia disease types include alopecia areata, telogen effluvium, anagen effluvium, traction effluvium, scar effluvium, etc.

Current alopecia treatments are invasive (i.e. surgical) or have a higher than expected risk of side effects. At present, finasteride and minoxidil are mainly used as medicaments for treating male hormone alopecia. Finasteride is a 4-azasteroid that is a specific inhibitor of the intracellular enzyme, type II 5 a-reductase, in the metabolism of testosterone to the stronger dihydrotestosterone. The primary therapeutic effect may not be apparent until 4 months later, and if effective, continued administration may result in continued hair loss. The minoxidil is classified as a potassium ion channel opener, has the effect of peripheral vasodilation, can enable tiny hair follicles to generate the effect of reversal regeneration to accelerate the growth of hair, and promotes the key point that the hair follicles enter the growth phase from the resting phase, and by using a product containing minoxidil, the increase of hair volume can be seen usually after 6-8 weeks, and after 12-16 weeks, obvious effect can be seen. However, not everyone can adapt to the above-mentioned period of validity, sometimes experience an increased hair loss, and it is described that minoxidil and finasteride can also delay, i.e. stop or reduce the degree of hair loss, but both drugs have certain side effects, finasteride inhibits androgens, possibly affecting the normal hormone homeostasis; minoxidil has blood pressure lowering effect, and is not recommended for patients with hypotension and heart disease.

Based on the above principle and by improving the prior art, it is very significant to develop an effective hair growth product with few side effects.

Disclosure of Invention

The present invention has been made to overcome the disadvantages of the prior art, and provides an amino acid solution composition for hair growth capable of promoting hair growth, improving the amount of thinning hair, and/or treating and/or preventing hair loss, and a method for preparing the same.

In order to achieve the purpose, the invention adopts the technical scheme that:

the amino acid solution composition for hair growth comprises, by weight, SR-182920.001-0.1 parts, L-carnitine 1-50 parts, raspberry ketone 0.1-10 parts, glutamine 1-100 parts, sodium hyaluronate 1-5 parts, amino acid humectant 10-50 parts, xylitol 10-50 parts, nicotinamide 10-50 parts, dexpanthenol 10-50 parts, phenoxyethanol 10 parts, benzalkonium chloride 1 part, hair keratin amino acid 10-50 parts, maltodextrin 10-50 parts, chitosan 1-5 parts, yeast glucan 1-5 parts, PEG10 lanolin 1-5 parts, laurocapram 10-50 parts, lauramidopropyl betaine 10-50 parts, isopropyl myristate 1-5 parts, lauryl alcohol polyether sodium sulfate 10-50 parts, and a liquid fluidity regulating substance as active ingredients, 1-5 parts of menthol, 1-5 parts of retinol acetate and 50 parts of glycerol.

Preferably, by weight, SR-182920.001-0.01 part, L-carnitine 10-50 parts, raspberry ketone 1-10 parts, glutamine 20-100 parts, sodium hyaluronate 1-3 parts, amino acid humectant 20-50 parts, xylitol 20-50 parts, nicotinamide 20-50 parts, dexpanthenol 30-50 parts, phenoxyethanol 10 parts, benzalkonium chloride 1 part, hair keratin amino acid 20-50 parts, maltodextrin 10-40 parts, chitosan 2-5 parts, yeast glucan 2-5 parts, PEG10 lanolin 2-5 parts, laurocapram 30-50 parts, laurocapram betaine 30-50 parts, isopropyl myristate 2-5 parts, sodium laureth sulfate 20-50 parts, menthol 1-5 parts, retinyl acetate 1-3 parts, and glycerol 50 parts.

Furthermore, the hair conditioner comprises, by weight, SR-182920.1 parts, L-carnitine 50 parts, raspberry ketone 10 parts, glutamine 100 parts, sodium hyaluronate 1.5 parts, amino acid humectant 2.5 parts, xylitol 31 parts, nicotinamide 21 parts, dexpanthenol 30 parts, phenoxyethanol 10 parts, benzalkonium chloride 1 part, hair keratin amino acid 25 parts, maltodextrin 30 parts, chitosan 3 parts, yeast glucan 2 parts, PEG10 lanolin 3 parts, laurocapram 40 parts, lauramidopropyl betaine 40 parts, isopropyl myristate 4 parts, sodium laureth sulfate 20 parts, menthol 1 part, retinyl acetate 3 parts, and glycerol 50 parts.

The composition is mixed with an auxiliary agent to form an amino acid solution preparation for hair growth; wherein the preparation is water agent, emulsion, unguent or ointment.

When the preparation is a water aqua, the weight part ratio of the composition to the auxiliary agent is 1: 1.4-2; wherein the auxiliary agent is one or more of water, ethanol and propylene glycol.

The auxiliary agent comprises, by weight, 0.9-1 part of water, 0.05-0.07 part of ethanol and 0.05-0.07 part of propylene glycol.

When the preparation is an ointment, the weight part ratio of the active ingredients to the auxiliary agents is 1: 1.4-2; wherein the auxiliary agent is water, ethanol, propylene glycol, 305 emulsifier.

The auxiliary agent comprises, by weight, 0.9-1 part of water, 0.05-0.07 part of ethanol, 0.05-0.07 part of propylene glycol and 0.01-0.02305 part of emulsifier.

When the preparation is an ointment, the weight part ratio of the active ingredients to the auxiliary agents is 1: 1.4-2; wherein the auxiliary agent is water, ethanol, propylene glycol and squalane.

The auxiliary agent comprises, by weight, 0.9-1 part of water, 0.05-0.07 part of ethanol, 0.05-0.07 part of propylene glycol and 0.01-0.02 part of squalane.

A hair growth amino acid solution composition is prepared by mixing adjuvant and water soluble substance at the above ratio, adding fat soluble substance into the mixture, mixing, adding liquid fluidity regulating substance into the mixture, stirring, and mixing to obtain hair growth amino acid solution composition.

Further, when preparing the aqueous solution:

a. adding 100 parts of water, 1-5 parts of lauramidopropyl betaine, 1.5 parts of sodium hyaluronate, 1-5 parts of amino acid humectant, 1-5 parts of nicotinamide, 1-5 parts of dexpanthenol, 1-100 parts of glutamine and 1-50 parts of L-carnitine into a container in sequence, and uniformly stirring to mix the components;

b. adding 5 parts of glycerol, 5 parts of propylene glycol, 5 parts of ethanol, 25-0.01 part of SR-182920.0001, 0.1-10 parts of raspberry ketone, 1 part of phenoxyethanol, 1 part of benzalkonium chloride, 1-5 parts of laurocapram, 0.1-0.5 part of isopropyl myristate, 1-5 parts of sodium laureth sulfate, 0.1-0.5 part of chitosan, 0.1-0.5 part of yeast glucan, 0.1-0.5 part of PEG10 lanolin and 0.1-0.5 part of retinol acetate into a container in sequence, stirring uniformly, mixing, introducing into the mixed solution in the step a, and fully stirring and mixing uniformly;

c. and (b) sequentially introducing 1-5 parts of hair keratin amino acid, 1-5 parts of xylitol, 1-5 parts of maltodextrin and 0.1-0.5 part of menthol into the mixed solution in the step a, and fully stirring and uniformly mixing to obtain a finished product.

The difference of the ointment or the salve from the aqueous solution is that 305 emulsifier or squalane is added according to the proportion in the step c.

When the amino acid solution composition for hair growth is used, the parts needing to be smeared are cleaned, and the essence is uniformly smeared on the scalp or the skin needing to grow hair once a day.

The main component SR-18292 is utilized in the amino acid solution composition for hair growth; providing an energy class: l-carnitine; hair raw material class: glutamine, hair keratin amino acids; moisturizing substances: raspberry ketone, sodium hyaluronate, amino acid humectant, dexpanthenol, yeast dextran, glycerol, xylitol, and PEG10 lanolin; blood circulation and cell proliferation promoters: the mixture of nicotinamide and retinol acetate can promote hair growth.

Among them, SR-18292 is a PPAR γ coactivator 1 α (PGC-1 α) inhibitor, which increases the acetylation degree of PGC-1 α, inhibits the expression of gluconeogenic genes, and reduces the glucose production in cells. Studies have shown that the content of PGC-1 alpha in the inner and outer root sheaths of the frontal follicles of male bald patients is greater than that of healthy persons, and PGC-1 alpha is not expressed during the resting stage of the follicles. These phenomena suggest that PGC-1. alpha. may promote entry of the follicular cycle into the telogen phase. SR-18292 used in the present invention can inhibit the action of PGC-1 alpha, thereby promoting entry of hair follicle into anagen phase or prolonging anagen phase.

L-carnitine helps to maintain cellular energy metabolism, facilitates the transport of fat through cell membranes into intracellular mitochondria, where the fat is oxidized to produce cellular energy ATP. It can increase the energy supply to the hair follicle, help the hair follicle cells to proliferate, and maintain the hair follicle in anagen phase.

Hair keratin is one of a family of fibrous structural proteins. It is a key structural material for hair. Hair keratin amino acids provide the starting material for the growth of hair in the hair follicle.

Glutamine is an amino acid. The main component of hair is keratin, which contains a large amount of cysteine. Large amounts of sulfur are required for the synthesis of cysteine. This sulphur is delivered to the scalp with the aid of glutamine.

Raspberry ketone is an aromatic compound mainly contained in Raspberry, and it can activate sensory neurons to increase IGF-I production in skin to increase skin elasticity and promote hair growth.

Sodium hyaluronate, which may also be referred to as sodium hyaluronate, is the sodium salt of hyaluronic acid. Sodium hyaluronate exists in extracellular matrix and cornea of multiple connective tissues of human body as glycosaminoglycan, is composed of D-glucuronic acid and N-acetyl-D-glucosamine, can improve skin water retention effect, and has effects of nourishing hair, caring hair and preventing alopecia by moistening scalp.

The amino acid humectant, named as trimethylglycine chemically, is a natural structural substance, namely a zwitterionic moisturizing component, can rapidly improve the moisture retention of skin and hair and stimulate cell activity, and has the effects of maintaining moisture, smoothness, and preventing dryness and darkness. Meanwhile, glycerin, xylitol and PEG10 lanolin also have the effects of moisturizing and moistening hair.

Dexpanthenol is also known as provitamin B5. Can be widely used in medicine, food, cosmetics and liquid preparation. D-panthenol can be converted into pantothenic acid when entering human body, and then coenzyme A is synthesized, so that metabolism of protein, fat and saccharide of human body is promoted, skin and mucosa are protected, hair growth is promoted, hair is kept moist, hair bifurcation is reduced, brittleness and breakage are prevented, and protection, repair and care effects on the head are achieved.

The yeast glucan can repair mucous membrane, and has the effects of moisturizing, growing hair, resisting oxidation and the like.

Nicotinamide is an amide of nicotinic acid (vitamin B3), a water-soluble vitamin and a member of the vitamin B group, and can improve blood circulation of the scalp and promote absorption of nutrients into hair follicles.

The retinol acetate can stimulate skin cells to regenerate and improve the skin environment around hair follicles.

The invention has the beneficial effects that:

the amino acid solution composition for hair growth of the present invention promotes the hair follicle to enter the anagen phase from the telogen phase, so that the hair grows.

The penetration enhancer contained in the amino acid solution can help the active ingredients to penetrate a barrier of a hydrophobic structure consisting of a cuticle and an epidermis and enter hair follicles without injection; and the active ingredient is a protein molecule for inhibiting the growth of the hair follicle stem cells in a targeting manner, and the negative regulation signal PGC-1 alpha is obtained, so that the hair follicle stem cells are reactivated, the hair follicle is promoted to enter a growth phase or the activity of the hair follicle stem cells is maintained, and the growth phase of the hair follicle is prolonged.

The amino acid solution composition also provides a hair growth raw material, and provides enough amino acid to promote hair growth.

In addition, the hair growth amino acid solution composition has the function of promoting the growth of hair follicle capillaries, further promotes the hair growth, and provides nutrients and growth factors.

The amino acid solution composition agent also has the moisturizing function, protects the environment of the skin matrix, moisturizes the hair, provides a good environment for the growth of the hair, and promotes the hair to grow vigorously.

Drawings

FIG. 1 is a graph of the average gray scale of mouse back hair using the components of each sample sequence provided in example 1 of the present invention;

FIG. 2 is an example of a photograph of a back hair of a mouse using the sequence components of each sample according to example 1 of the present invention.

Detailed Description

The embodiments of the present invention will be further described with reference to the accompanying drawings and specific examples, it should be noted that the embodiments described herein are only for the purpose of illustrating and explaining the present invention and are not limited to the present invention.

Example (b):

the aqueous products used in the following examples were prepared according to the following steps:

adding the components recorded in each sample in the table 1 to respectively obtain samples containing different specific components, firstly, uniformly mixing the auxiliary agent and the water-soluble substance according to the proportion, and adding the fat-soluble substance into the mixture for uniform mixing to obtain the amino acid solution combined agent samples containing different components and different addition amounts for hair growth.

a. Mixing water and water-soluble substances in the active ingredients according to the proportion shown in table 1, namely sequentially adding the water and several substances of L-carnitine, lauramidopropyl betaine, sodium hyaluronate, amino acid humectant, nicotinamide, dexpanthenol and glutamine into a container, and uniformly stirring to uniformly mix the water and the water-soluble substances;

b. mixing glycerol, propylene glycol, ethanol and fat-soluble substances in the active ingredients according to the proportion shown in the table 1, namely sequentially adding the glycerol, the propylene glycol, the ethanol, the phenoxyethanol, the benzalkonium chloride, the laurocapram, the isopropyl myristate, the sodium laureth sulfate, the chitosan, the yeast glucan, the PEG10 lanolin, the retinol acetate and the SR-18292 into another container, uniformly stirring, uniformly mixing, then introducing into the mixed solution in the step a, and continuously and fully stirring and uniformly mixing;

c. and (3) introducing a substance for adjusting the liquid fluidity of the active substance in the active ingredients into the mixed solution in the step (b) according to the proportion shown in the table 1, namely, sequentially introducing hair keratin amino acid, xylitol, maltodextrin and menthol into the mixed solution in the step (b), and fully stirring and uniformly mixing to obtain a finished product.

Table 1 below shows the mixture of each component in parts by mass of each sample, and the gray level of each component was measured by image j according to a photograph of the back of a mouse taken with a microscope (see fig. 1), and the average back gray level of three mice measured (mouse a back gray level + mouse b back gray level + mouse c back gray level)/3 was used as a hair growth effect index, and the larger the value, the better the hair growth effect was.

Table 1: composition and hair growth promoting effect of each sample sequence in 9 sample sequences

In the above table, "-" is not added.

As can be seen from FIG. 1, the sample sequence 1 is a sample to which no hair growth promoting active ingredient is added; the sample sequence 2-13 is a sample obtained by adding a certain effective component less in sequence; the samples with the optimal proportion of each component in the sample sequence 13 can promote the growth of the hair most.

The sample products prepared above were applied to the backs of mice by collecting C57 wild type mice, performing a back depilation treatment in the eighth week after birth, and applying the hair growth products in each sample sequence in table 1 daily. Photographs were taken 10 days after the experiment to control the back hair growth (see fig. 2). The average back gray value is used as a hair growth effect index, namely the larger the value is, the better the hair growth effect is.

As is apparent from the data in table 1, the sample sequences 2 to 13 all have hair growth promoting effects, wherein the sequence 13, i.e., the mouse with the optimal ratio of the effective components, has the best whitening effect, and the mouse with the sample sequence 1 has almost no hair growth promoting effect. Thus, it can be seen that each of the active ingredients described in the present invention has a role in hair growth products, but not a disadvantage.

Finally, it should be noted that the above-mentioned contents are only used for illustrating the technical solutions of the present invention, and not for limiting the protection scope of the present invention, and that the simple modifications or equivalent substitutions of the technical solutions of the present invention by those of ordinary skill in the art can be made without departing from the spirit and scope of the technical solutions of the present invention.

Claims

1. A hair-growing amino acid solution composition characterized by: the composition comprises water-soluble substances, fat-soluble substances and substances for regulating the liquid fluidity of active ingredients, wherein the ingredients comprise, by weight, SR-182920.001-0.1 part, L-carnitine 1-50 parts, raspberry ketone 0.1-10 parts, glutamine 1-100 parts, sodium hyaluronate 1-5 parts, amino acid humectant 10-50 parts, xylitol 10-50 parts, nicotinamide 10-50 parts, dexpanthenol 10-50 parts and phenoxyethanol 10 parts, 1 part of benzalkonium chloride, 10-50 parts of hair keratin amino acid, 10-50 parts of maltodextrin, 1-5 parts of chitosan, 1-5 parts of yeast glucan, 1-5 parts of PEG10 lanolin, 10-50 parts of laurocapram, 10-50 parts of lauramidopropyl betaine, 1-5 parts of isopropyl myristate, 10-50 parts of sodium laureth sulfate, 1-5 parts of menthol, 1-5 parts of retinyl acetate and 50 parts of glycerol.

2. The hair growth amino acid solution composition according to claim 1, characterized in that: SR-182920.001-0.01 part, L-carnitine 10-50 parts, raspberry ketone 1-10 parts, glutamine 20-100 parts, sodium hyaluronate 1-3 parts, amino acid humectant 20-50 parts, xylitol 20-50 parts, nicotinamide 20-50 parts, dexpanthenol 30-50 parts, phenoxyethanol 10 parts, benzalkonium chloride 1 part, hair keratin amino acid 20-50 parts, maltodextrin 10-40 parts, chitosan 2-5 parts, yeast glucan 2-5 parts, PEG10 lanolin 2-5 parts, laurocapram 30-50 parts, isopropyl myristate 2-5 parts, sodium laureth sulfate 20-50 parts, menthol 1-5 parts, retinol acetate 1-3 parts, and glycerol 50 parts.

3. The hair growth amino acid solution composition according to claim 1 or 2, characterized in that: the composition is mixed with an auxiliary agent to form an amino acid solution preparation for hair growth; wherein the preparation is water agent, emulsion, unguent or ointment.

4. The hair growth amino acid solution composition according to claim 3, wherein: when the preparation is a water aqua, the weight part ratio of the composition to the auxiliary agent is 1: 1.4-2; wherein the auxiliary agent is one or more of water, ethanol and propylene glycol.

5. The hair growth amino acid solution composition according to claim 4, wherein: the auxiliary agent comprises, by weight, 0.9-1 part of water, 0.05-0.07 part of ethanol and 0.05-0.07 part of propylene glycol.

6. The hair growth amino acid solution composition according to claim 3, wherein: when the preparation is an ointment, the weight part ratio of the active ingredients to the auxiliary agents is 1: 1.4-2; wherein the auxiliary agent is water, ethanol, propylene glycol, 305 emulsifier.

7. The hair growth amino acid solution composition according to claim 6, wherein: the auxiliary agent comprises, by weight, 0.9-1 part of water, 0.05-0.07 part of ethanol, 0.05-0.07 part of propylene glycol and 0.01-0.02305 part of emulsifier.

8. The hair growth amino acid solution composition according to claim 3, wherein: when the preparation is an ointment, the weight part ratio of the active ingredients to the auxiliary agents is 1: 1.4-2; wherein the auxiliary agent is water, ethanol, propylene glycol and squalane.

9. The hair growth amino acid solution composition according to claim 8, wherein: the auxiliary agent comprises, by weight, 0.9-1 part of water, 0.05-0.07 part of ethanol, 0.05-0.07 part of propylene glycol and 0.01-0.02 part of squalane.

10. A method for preparing the hair-growing amino acid solution composition according to claim 1, wherein: and uniformly mixing the auxiliary agent and the water-soluble substance according to the proportion, adding the fat-soluble substance into the mixture, uniformly mixing, adding the liquid fluidity regulating substance of the active ingredient into the mixture, and uniformly stirring to obtain the amino acid solution composition for hair growth.