JPH01242516A - Hair tonic, hair shampoo and hair growing promoter - Google Patents
Hair tonic, hair shampoo and hair growing promoterInfo
- Publication number
- JPH01242516A JPH01242516A JP63068335A JP6833588A JPH01242516A JP H01242516 A JPH01242516 A JP H01242516A JP 63068335 A JP63068335 A JP 63068335A JP 6833588 A JP6833588 A JP 6833588A JP H01242516 A JPH01242516 A JP H01242516A
- Authority
- JP
- Japan
- Prior art keywords
- hair
- polysorbate
- biotin
- hair growth
- hyaluronic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 210000004209 hair Anatomy 0.000 title claims abstract description 37
- 239000002453 shampoo Substances 0.000 title claims abstract description 15
- 230000001256 tonic effect Effects 0.000 title abstract description 7
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 claims abstract description 20
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 19
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 16
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims abstract description 11
- PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 claims abstract description 10
- 229960002685 biotin Drugs 0.000 claims abstract description 10
- 235000020958 biotin Nutrition 0.000 claims abstract description 10
- 239000011616 biotin Substances 0.000 claims abstract description 10
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims abstract description 9
- 229920002674 hyaluronan Polymers 0.000 claims abstract description 9
- 229960003160 hyaluronic acid Drugs 0.000 claims abstract description 9
- 229960003512 nicotinic acid Drugs 0.000 claims abstract description 8
- 235000001968 nicotinic acid Nutrition 0.000 claims abstract description 8
- 239000011664 nicotinic acid Substances 0.000 claims abstract description 8
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 claims abstract description 8
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims abstract description 8
- 229920000053 polysorbate 80 Polymers 0.000 claims abstract description 8
- 229940068968 polysorbate 80 Drugs 0.000 claims abstract description 8
- 235000011187 glycerol Nutrition 0.000 claims abstract description 7
- 240000003538 Chamaemelum nobile Species 0.000 claims abstract description 6
- 235000007866 Chamaemelum nobile Nutrition 0.000 claims abstract description 6
- 235000007232 Matricaria chamomilla Nutrition 0.000 claims abstract description 6
- -1 olefin sulfate Chemical class 0.000 claims abstract description 6
- 239000004094 surface-active agent Substances 0.000 claims abstract description 6
- 229920001214 Polysorbate 60 Polymers 0.000 claims abstract description 5
- 229930003427 Vitamin E Natural products 0.000 claims abstract description 5
- 150000001413 amino acids Chemical class 0.000 claims abstract description 5
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims abstract description 5
- 239000001818 polyoxyethylene sorbitan monostearate Substances 0.000 claims abstract description 5
- 235000010989 polyoxyethylene sorbitan monostearate Nutrition 0.000 claims abstract description 5
- 229940113124 polysorbate 60 Drugs 0.000 claims abstract description 5
- 235000019165 vitamin E Nutrition 0.000 claims abstract description 5
- 239000011709 vitamin E Substances 0.000 claims abstract description 5
- 229940046009 vitamin E Drugs 0.000 claims abstract description 5
- MSCCTZZBYHQMQJ-AZAGJHQNSA-N Tocopheryl nicotinate Chemical compound C([C@@](OC1=C(C)C=2C)(C)CCC[C@H](C)CCC[C@H](C)CCCC(C)C)CC1=C(C)C=2OC(=O)C1=CC=CN=C1 MSCCTZZBYHQMQJ-AZAGJHQNSA-N 0.000 claims abstract description 4
- MRUAUOIMASANKQ-UHFFFAOYSA-N cocamidopropyl betaine Chemical compound CCCCCCCCCCCC(=O)NCCC[N+](C)(C)CC([O-])=O MRUAUOIMASANKQ-UHFFFAOYSA-N 0.000 claims abstract description 4
- 229940073507 cocamidopropyl betaine Drugs 0.000 claims abstract description 4
- JRZJOMJEPLMPRA-UHFFFAOYSA-N olefin Natural products CCCCCCCC=C JRZJOMJEPLMPRA-UHFFFAOYSA-N 0.000 claims abstract description 4
- 239000003960 organic solvent Substances 0.000 claims abstract description 4
- 229950009883 tocopheryl nicotinate Drugs 0.000 claims abstract description 4
- 239000008234 soft water Substances 0.000 claims abstract description 3
- 229960005150 glycerol Drugs 0.000 claims abstract 3
- 235000013311 vegetables Nutrition 0.000 claims description 2
- 239000000306 component Substances 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 16
- 210000004761 scalp Anatomy 0.000 abstract description 14
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 abstract description 8
- 230000017531 blood circulation Effects 0.000 abstract description 7
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 abstract description 5
- 239000004292 methyl p-hydroxybenzoate Substances 0.000 abstract description 4
- 229960002216 methylparaben Drugs 0.000 abstract description 4
- 239000004480 active ingredient Substances 0.000 abstract description 3
- 239000004902 Softening Agent Substances 0.000 abstract description 2
- 239000002075 main ingredient Substances 0.000 abstract description 2
- 210000004927 skin cell Anatomy 0.000 abstract description 2
- 241000196324 Embryophyta Species 0.000 abstract 1
- 230000029553 photosynthesis Effects 0.000 abstract 1
- 238000010672 photosynthesis Methods 0.000 abstract 1
- 230000004936 stimulating effect Effects 0.000 abstract 1
- 230000003779 hair growth Effects 0.000 description 51
- 239000007952 growth promoter Substances 0.000 description 9
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 7
- 201000004384 Alopecia Diseases 0.000 description 6
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 description 6
- 229920000136 polysorbate Polymers 0.000 description 6
- 229950008882 polysorbate Drugs 0.000 description 5
- 230000001737 promoting effect Effects 0.000 description 5
- 239000005556 hormone Substances 0.000 description 4
- 229940088597 hormone Drugs 0.000 description 4
- 235000015961 tonic Nutrition 0.000 description 4
- 235000019155 vitamin A Nutrition 0.000 description 4
- 239000011719 vitamin A Substances 0.000 description 4
- OVBPIULPVIDEAO-UHFFFAOYSA-N N-Pteroyl-L-glutaminsaeure Natural products C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-UHFFFAOYSA-N 0.000 description 3
- 206010068168 androgenetic alopecia Diseases 0.000 description 3
- 229960000304 folic acid Drugs 0.000 description 3
- 235000019152 folic acid Nutrition 0.000 description 3
- 239000011724 folic acid Substances 0.000 description 3
- 239000003205 fragrance Substances 0.000 description 3
- 230000003676 hair loss Effects 0.000 description 3
- 239000004615 ingredient Substances 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 210000003491 skin Anatomy 0.000 description 3
- RGZSQWQPBWRIAQ-CABCVRRESA-N (-)-alpha-Bisabolol Chemical compound CC(C)=CCC[C@](C)(O)[C@H]1CCC(C)=CC1 RGZSQWQPBWRIAQ-CABCVRRESA-N 0.000 description 2
- 239000001500 (2R)-6-methyl-2-[(1R)-4-methyl-1-cyclohex-3-enyl]hept-5-en-2-ol Substances 0.000 description 2
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 description 2
- 206010040880 Skin irritation Diseases 0.000 description 2
- FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 description 2
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 description 2
- POJWUDADGALRAB-UHFFFAOYSA-N allantoin Chemical compound NC(=O)NC1NC(=O)NC1=O POJWUDADGALRAB-UHFFFAOYSA-N 0.000 description 2
- RGZSQWQPBWRIAQ-LSDHHAIUSA-N alpha-Bisabolol Natural products CC(C)=CCC[C@@](C)(O)[C@@H]1CCC(C)=CC1 RGZSQWQPBWRIAQ-LSDHHAIUSA-N 0.000 description 2
- 230000003110 anti-inflammatory effect Effects 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 2
- 238000007796 conventional method Methods 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 208000024963 hair loss Diseases 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 244000005700 microbiome Species 0.000 description 2
- 102000039446 nucleic acids Human genes 0.000 description 2
- 108020004707 nucleic acids Proteins 0.000 description 2
- 150000007523 nucleic acids Chemical class 0.000 description 2
- 210000000056 organ Anatomy 0.000 description 2
- 230000035515 penetration Effects 0.000 description 2
- 210000005259 peripheral blood Anatomy 0.000 description 2
- 239000011886 peripheral blood Substances 0.000 description 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 2
- 210000001732 sebaceous gland Anatomy 0.000 description 2
- 230000028327 secretion Effects 0.000 description 2
- 230000036556 skin irritation Effects 0.000 description 2
- 231100000475 skin irritation Toxicity 0.000 description 2
- 229960000716 tonics Drugs 0.000 description 2
- 229940088594 vitamin Drugs 0.000 description 2
- 229930003231 vitamin Natural products 0.000 description 2
- 235000013343 vitamin Nutrition 0.000 description 2
- 239000011782 vitamin Substances 0.000 description 2
- 229940045997 vitamin a Drugs 0.000 description 2
- POJWUDADGALRAB-PVQJCKRUSA-N Allantoin Natural products NC(=O)N[C@@H]1NC(=O)NC1=O POJWUDADGALRAB-PVQJCKRUSA-N 0.000 description 1
- 241001116389 Aloe Species 0.000 description 1
- 101100406774 Arabidopsis thaliana PAB8 gene Proteins 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- KWIUHFFTVRNATP-UHFFFAOYSA-N Betaine Natural products C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 description 1
- 206010015946 Eye irritation Diseases 0.000 description 1
- 208000034826 Genetic Predisposition to Disease Diseases 0.000 description 1
- 102000011782 Keratins Human genes 0.000 description 1
- 108010076876 Keratins Proteins 0.000 description 1
- KWIUHFFTVRNATP-UHFFFAOYSA-O N,N,N-trimethylglycinium Chemical compound C[N+](C)(C)CC(O)=O KWIUHFFTVRNATP-UHFFFAOYSA-O 0.000 description 1
- 206010029333 Neurosis Diseases 0.000 description 1
- 108010013381 Porins Proteins 0.000 description 1
- 240000002299 Symphytum officinale Species 0.000 description 1
- 235000005865 Symphytum officinale Nutrition 0.000 description 1
- 230000005856 abnormality Effects 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 125000003158 alcohol group Chemical group 0.000 description 1
- 229960000458 allantoin Drugs 0.000 description 1
- 235000011399 aloe vera Nutrition 0.000 description 1
- 201000002996 androgenic alopecia Diseases 0.000 description 1
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 1
- 229960003237 betaine Drugs 0.000 description 1
- 230000001914 calming effect Effects 0.000 description 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-N carbonic acid Chemical compound OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 description 1
- 235000012000 cholesterol Nutrition 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000006866 deterioration Effects 0.000 description 1
- 230000002542 deteriorative effect Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 239000003974 emollient agent Substances 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 231100000013 eye irritation Toxicity 0.000 description 1
- 235000013373 food additive Nutrition 0.000 description 1
- 239000002778 food additive Substances 0.000 description 1
- 230000000855 fungicidal effect Effects 0.000 description 1
- 239000000417 fungicide Substances 0.000 description 1
- 210000002768 hair cell Anatomy 0.000 description 1
- 239000003906 humectant Substances 0.000 description 1
- 230000009545 invasion Effects 0.000 description 1
- 229940119170 jojoba wax Drugs 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 239000006210 lotion Substances 0.000 description 1
- 230000003273 male-pattern hair loss Effects 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 208000015238 neurotic disease Diseases 0.000 description 1
- 231100000957 no side effect Toxicity 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 230000000149 penetrating effect Effects 0.000 description 1
- 150000002978 peroxides Chemical class 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 230000007096 poisonous effect Effects 0.000 description 1
- 229940068965 polysorbates Drugs 0.000 description 1
- 102000007739 porin activity proteins Human genes 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 238000001243 protein synthesis Methods 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 210000002374 sebum Anatomy 0.000 description 1
- 238000002791 soaking Methods 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 230000035882 stress Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 229930003799 tocopherol Natural products 0.000 description 1
- 235000010384 tocopherol Nutrition 0.000 description 1
- 229960001295 tocopherol Drugs 0.000 description 1
- 239000011732 tocopherol Substances 0.000 description 1
- 230000014616 translation Effects 0.000 description 1
- 235000019156 vitamin B Nutrition 0.000 description 1
- 239000011720 vitamin B Substances 0.000 description 1
- 229940046001 vitamin b complex Drugs 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 1
Landscapes
- Cosmetics (AREA)
Abstract
Description
【発明の詳細な説明】
［産業上の利用分野コ
この発明は、養毛剤、養毛シャンプー及び養−毛促進剤
に１対シ、更に詳しくはポリソルベート、ビタミンＡ、
Ｄ、Ｅ、界面活性剤、アルコールとを含有するのでベト
付かず、優れた発毛、ｋ毛効果を有し、局所的に有効で
、口や身体に副作用がなく、又皮膚刺激性が全くなく、
安全性が高い養毛剤、同じくポリソルベート、ビタミン
Ａ、Ｄ、［等を含有する養毛シャンプー及びビタミンＥ
＝）−コフエロール等を含有する養毛促進剤に関する。DETAILED DESCRIPTION OF THE INVENTION [Industrial Field of Application] This invention is directed to hair nourishing agents, hair nourishing shampoos, and hair nourishing promoters, more specifically polysorbates, vitamin A,
Contains D, E, surfactant, and alcohol, so it is non-sticky, has excellent hair growth and K hair effects, is locally effective, has no side effects on the mouth or body, and has no skin irritation. Without,
Highly safe hair nourishing shampoos and vitamin E containing polysorbate, vitamins A, D, etc.
=)-Relating to a hair growth promoter containing cofuerol and the like.
［従来の技術］
男性型脱毛症には多くの種類の養毛剤が提案されている
が、卓効を発揮する養毛剤はいまだ見られない。[Prior Art] Many types of hair restorers have been proposed for treating male pattern baldness, but no hair restorer that is highly effective has yet been found.
［発明が解決しようとする課題１
男性型脱毛症の原図は、（ａ）男性ホルモンの過剰蓄積
、（Ｉ））毛根、皮脂腺等の器官に於ける男性ホルモン
の活性化、（Ｃ）頭皮の毛細血管への血流量の低下、（
ｄ）皮脂の分泌過剰、過酸化物の生成、４ｍ菌の繁殖等
による頭皮の異常、（ｅ）遺伝的素置、（ｒ）ストレス
等にによる神経症、（ｇ）疾病による影秤、（ｈ）老化
等が挙げられている。[Problem to be solved by the invention 1 The origin of androgenetic alopecia is (a) excessive accumulation of male hormones, (I) activation of male hormones in organs such as hair roots and sebaceous glands, and (C) scalp Reduced blood flow to capillaries, (
d) Scalp abnormalities due to excessive secretion of sebum, production of peroxide, proliferation of 4m bacteria, etc., (e) Genetic predisposition, (r) Neurosis due to stress, etc., (g) Influenced by disease, ( h) Aging, etc. are mentioned.
そこで男性型脱毛症の治療と育毛には、頭皮の血行を促
進したり、上げ細胞を活性化したり、開度の脂質の分泌
を抑制する薬剤を組合わせたものや、毛髪の栄養成分で
あるアミノ酸やビタミン類を配合するもの、男性ホルモ
ンを抑制するもの等が提案されている。Therefore, for the treatment of male pattern baldness and hair growth, a combination of drugs that promote blood circulation in the scalp, activate hair cells, and suppress the secretion of lipids in the scalp, as well as hair nutritional ingredients are recommended. Products that contain amino acids and vitamins, and products that suppress male hormones have been proposed.
又公知の養毛剤は、アルコ−ルを基剤にしたものが多く
、従って製造後相当長期間経つと容易に分解変質する大
きな欠点がある。Furthermore, many of the known hair nourishing agents are alcohol-based, and therefore have the major drawback of easily decomposing and deteriorating after a considerable period of time after manufacture.
そして公知の養毛剤は、塗布方法が厄介だったり、塗布
が多い割には実質的発毛、養毛効果が少なく、頭皮や毛
髪にベト付くものが多かった。Known hair tonics have a cumbersome application method, have little substantial hair growth and hair growth effect despite being applied often, and are often sticky to the scalp and hair.
し課題を解決するための手段］ 前述の目的を達成するため、この発明に於いては。[Means to solve the problem] In order to achieve the above-mentioned object, in this invention.
ポリソルベート８０、ポリソルベート６０、ビオチン、
ニコチン酸、メチルパラベン、天然香料、界面活性剤、
アルコールとを含有する養毛剤により発毛、養毛させ、
ポリソルベート、ビタミンＡ、Ｄ−Ｅ等を含有する養毛
シャンプーにより養毛を促進し、更にビタミンＥ、トコ
フェロール等を含有する養毛促進剤により養毛を促進す
るものであり、その特徴は水を基剤とし、しかも従来の
養毛剤の様にべ１・付かす、確実な発毛、養毛作用を有
する養毛剤、養毛シャンプー及びに養毛促進剤を提供す
るものである。polysorbate 80, polysorbate 60, biotin,
Nicotinic acid, methylparaben, natural fragrance, surfactant,
Hair growth and nourishment with a hair growth agent containing alcohol,
It promotes hair growth with a hair growth shampoo containing polysorbate, vitamins A, D-E, etc., and further promotes hair growth with a hair growth promoter containing vitamin E, tocopherol, etc. To provide a hair growth agent, a hair growth shampoo, and a hair growth promoter that have reliable hair growth and hair growth effects, as a base, and can be applied like conventional hair growth agents.
更にこの発明は、長期間でも殆ど変質せず、禿げや脱毛
に優れた効果を有する養毛剤、養毛シャンプー及び養毛
促進剤を提供するものである。Furthermore, the present invention provides a hair growth agent, a hair growth shampoo, and a hair growth promoter that hardly change in quality even over a long period of time and have excellent effects on baldness and hair loss.
そしてこの発明の養毛剤に含有されるポリソルベート８
０は、本来界面活性剤であり、従来食品添加剤としても
使用されていたが、その養毛作用は全く知られていなか
った。And polysorbate 8 contained in the hair growth agent of this invention
0 is originally a surfactant and has been used as a food additive, but its hair-nourishing effect was completely unknown.
この発明に係る養毛剤は、ポリソルベート８０、ポリソ
ルベート６０の他に、製薬上許容される添加剤及び他の
薬剤を添加した混合物の形で使用するものとする。The hair growth agent according to the present invention is used in the form of a mixture containing polysorbate 80 and polysorbate 60, as well as pharmaceutically acceptable additives and other drugs.
前述の通りの成分を含有する養毛剤は、常法に従ってヘ
ヤートニック、ヘヤーロージョン、ヘヤークリーム等の
性状又は剤型に調整出来る。The hair tonic containing the above-mentioned ingredients can be adjusted to the properties or dosage forms of hair tonics, hair lotions, hair creams, etc. according to conventional methods.
この養毛剤に含有されるビオチンは、炭酸同化作用の機
能低下を回復させ、ナイアシンは、頭皮の血行を促進さ
せ、メチル・パラベンは、変質防止剤であり、ヒアルロ
ン酸は、皮膚細胞に対する軟化剤として作用し、１１毛
、養毛効果を有する。即ち頭皮を軟化してその状態を改
善し、上前の周囲の細胞を軟化するものである。従って
主剤の浸透を助長し、その部分の皮膚末梢血管を拡張し
て値打を増やし、育毛、養毛効果を発揮するものである
。そして高い粘稠性を有する場合は、ｍ菌の侵入や毒物
の浸透を防ぐ効果をもたらす。The biotin contained in this hair tonic restores the decreased function of carbonic acid assimilation, the niacin promotes blood circulation in the scalp, the methyl parabens act as deterioration prevention agents, and the hyaluronic acid acts as a softening agent for skin cells. It acts on 11 hairs and has a hair-nourishing effect. That is, it softens the scalp and improves its condition, and softens the surrounding cells in the front and back. Therefore, it promotes the penetration of the main ingredient, dilates the skin's peripheral blood vessels in that area, increases its value, and exhibits hair-growth and hair-nourishing effects. When it has high viscosity, it has the effect of preventing the invasion of microorganisms and the penetration of poisonous substances.
又アルファ・ビサボロールは、カミツレ花抽出液内の有
効成分であり、沈静効果と抗炎症効果とを有する。Alpha-bisabolol is also an active ingredient in chamomile flower extract and has calming and anti-inflammatory effects.
養毛シャンプーに含有されるオレフィンサルフェ一部は
、浸透作用を有し、カミツレ花抽出液は、浸遥消炎作用
を有し、コカミド１０ピル・ベタインは、安定剤の一種
であり、養毛シャンプーの試活材として作用し、ケラチ
ン・アミノ蛋白は、毛髪の成分の一部となり、コンフリ
ー・アラントインは、成長促進、外（８治癒促進作用を
有する。A part of the olefin sulfate contained in the hair-growth shampoo has a penetrating effect, chamomile flower extract has a soaking and anti-inflammatory effect, and Cocamide 10 Pill Betaine is a type of stabilizer and has a hair-growth effect. It acts as an active ingredient in shampoo, keratin and amino protein become part of the hair components, and comfrey and allantoin have growth-promoting and healing-promoting effects.
更にトバンテノールは、毛髪成長促進作用を有し、グリ
セリンは、湿潤剤、粘滑剤として皮膚に外用される。Furthermore, tobantenol has a hair growth promoting effect, and glycerin is used externally on the skin as a humectant and demulcent.
そしてジョジョバ油は、飽和高級アルコールの一種であ
り、 ＰＡＢ八は、（Ｐ−アミノ安、Ｑ、香酸）は、防
カビ剤として作用し、核酸は、細胞内で蛋白質の合成に
寄与する。Jojoba oil is a type of saturated higher alcohol, PAB8 (P-aminoamine, Q, aromatic acid) acts as a fungicide, and nucleic acids contribute to protein synthesis within cells.
他方葉酸は、ビタミンＢ複合体の一種であり、アミノ酸
の定星を実施する場合の培養液に微生物のビタミンとし
て添加されるものであり、養毛促進効果を有する。On the other hand, folic acid is a type of vitamin B complex, is added as a vitamin for microorganisms to the culture solution when amino acid determination is carried out, and has a hair growth promoting effect.
養毛促進剤に含有されるニコチン酸トコフェロールは、
頭皮の血行促進により養毛促進効果を有し、タカノール
は、アミノビニール化合物で、代謝を助ｉして発毛、養
毛を促進させる。Tocopherol nicotinate contained in hair growth promoters is
Takanol has a hair growth promoting effect by promoting blood circulation in the scalp, and Takanol is an aminovinyl compound that aids metabolism and promotes hair growth and hair growth.
［３用コ
この発明の養毛剤に含有されるポリソルベート８０．６
０は、頭皮の皮膚末梢血管を拡張して血行を増やし、育
毛、養毛効果を発揮毛細面管への血行を増加させ、毛根
、皮脂腺等の器官に於ける男性ホルモンの活性化とコレ
ステロールを抑え、養毛作用を高めるものである。[3] Polysorbate 80.6 contained in the hair growth agent of this invention
0 expands the skin peripheral blood vessels of the scalp and increases blood circulation, which has a hair growth and hair nourishing effect.It increases blood circulation to the capillary tubes, activates male hormones in organs such as hair roots and sebaceous glands, and reduces cholesterol. It suppresses hair loss and enhances hair growth.
その結果養毛剤のポリソルベート８０．６０．ビオチン
、ナイアシン、界面活性剤、ヒアルロン酸並びに５・〜
１０′１の有機溶剤、養毛シャンプーのオレフィンサル
フェート、カミツレ花抽出液、コカミドプロピル・ベタ
イン並びに養毛１足進剤のアミノ７１９２２００ｃｏｍ
ｐｌｅｘ 、ヒタミンＦ、ニコチン酸Ｉ〜コフエロール
、タカノール並びヒアルロン酸等により相乗効果的にｆ
（毛、養毛作用を促進する。As a result, the hair growth agent polysorbate was 80.60. Biotin, niacin, surfactant, hyaluronic acid and 5...
10'1 organic solvent, hair nourishing shampoo olefin sulfate, chamomile flower extract, cocamidopropyl betaine, and hair nourishing booster Amino 7192200com
plex, hitamine F, nicotinic acid I to coferol, tacanol, hyaluronic acid, etc. synergistically
(Promotes hair growth and hair growth.
［実施例］
この発明の養毛剤の実施例を詳述するが、この成分は重
Ｖ％を示すものとする。[Example] Examples of the hair growth agent of the present invention will be described in detail, assuming that this component shows a weight V%.
ポリソルベート８０ ．１７０００ポリン
ルベート６０ 、０８０００ビオチン
０００５０ナイアシン
０００５０メチル・パラベン
、 ００３００天然香料 、
０００５０アルコール 、 ０
５００Ｇヒアルロン酸 ００００１
アルフア・ビサボロール ００００５実施例２
次の処方で常法によって養毛シャンプーを製造した。Polysorbate 80. 17000 porin rubate 60, 08000 biotin 00050 niacin
00050 Methyl paraben
, 00300 natural fragrance ,
00050 alcohol, 0
500G hyaluronic acid 00001
Alpha Bisabolol 00005 Example 2 A hair nourishing shampoo was produced using the following formulation in a conventional manner.
精製軟水 ５５６９オレフインサ
ルフエート ２０００カミツレ花抽出液
０５００ゲル状アロエ 、
０５００コカミドプロピル・ベタイン ０９５０グリ
セリン ０１５０ジコジジバ油
０００２支芽油
０００２Ｐ−アミノ安、Ｑ、香酸 ００
０２ビタミンＡ 、Ｄ 、Ｅ 、０００
５ビオチン 、 ００３０ポリソ
ルベー） ８０ 、００２５核酸（Ｒ
ＮＡ−ＤＮＡ） 、 ０００１葉酸
０００１メチル・パラ
ベン ００３００天然香料
、０１２５実施例３
次の処方で常法によって養毛促進剤を製造した。Purified soft water 5569 Oleph insulfate 2000 Chamomile flower extract
0500 gel aloe,
0500 Cocamidopropyl Betaine 0950 Glycerin 0150 Zikoziba Oil
0002 Branch oil
0002P-aminoamine, Q, folic acid 00
02 Vitamin A, D, E, 000
5 biotin, 0030 polysorbet) 80, 0025 nucleic acid (R
NA-DNA), 0001 folic acid
0001 Methyl paraben 00300 Natural fragrance
, 0125 Example 3 A hair growth promoter was produced by a conventional method using the following formulation.
植物グリセリン 、９８７４６アミノ酸
２２００ｃｏ曽ｐｌｅｘ 、 ００５００
ビタミンＥニコチン酸
トコフェロール ００７５０
タカノール 、 ００００２ヒアル
ロン酸 ００００２治験例１
この養毛剤、養毛シャンプー、養毛促進剤を男性型脱毛
型患者１０名により養毛効果を実施した。その「ヒト頭
髪成長促進効果試験法」を次に示す。Vegetable glycerin, 98746 amino acids 2200 coplex, 00500
Vitamin E Tocopherol Nicotinate 00750 Takanol, 00002 Hyaluronic Acid 00002 Clinical Trial Example 1 The hair growth effect of this hair growth agent, hair growth shampoo, and hair growth promoter was tested on 10 patients with male pattern hair loss. The "human hair growth promoting effect testing method" is shown below.
３５歳の男性被検者は過去１０年にわたって、徐々に頭
髪が薄くなっていた。The 35-year-old male subject had been experiencing gradual thinning of his hair over the past 10 years.
先ず養毛シャンプーにより頭皮と頭髪とをシャンプーし
、乾燥後養毛剤を手掌に数ｈ４とって毎日頭皮に塗擦し
た。First, the scalp and hair were shampooed with a hair nourishing shampoo, and after drying, several hours of hair nourishing agent was placed on the palm of the hand and rubbed onto the scalp every day.
所要に応じ養毛剤を塗布後、養毛促進剤を手掌に数滴と
り、−週間数回頭皮に塗擦した。After applying the hair growth agent as required, a few drops of the hair growth promoter were placed on the palm of the hand and rubbed onto the scalp several times a week.
それを９０目継続した結果、前述の成分の相乗効果によ
り、顕著な育毛、養毛効果が得られた。As a result of continuing this for 90 times, remarkable hair growth and hair nourishing effects were obtained due to the synergistic effect of the above-mentioned ingredients.
養毛剤に有機溶剤としてエタノール５ｚを添加しなので
頭皮や毛髪にベト付かず、アルコールを基剤とせず、水
を基剤としたので長１用間保存しても全く変質せず、安
定であって、その商品価値は極めて高５ゝパ：
ぞしてこの発明に係る養毛剤、養毛シャンプー及び養毛
促進剤は、局所的に極めて有効で、全身的に全く副作用
がなく、目や皮膚刺激性もなく、安全性が高いものであ
る。Ethanol 5z is added to the hair growth agent as an organic solvent, so it does not stick to the scalp or hair, and since it is not alcohol-based, it is water-based, so it does not deteriorate at all and is stable even when stored for a long time. Therefore, the hair growth agent, hair growth shampoo, and hair growth promoter according to the present invention are extremely effective locally, have no systemic side effects, and do not cause eye or skin irritation. It is highly safe.
Claims (1)
成分とし、これにビオチン、ナイアシン、界面活性剤、
ヒアルロン酸並びに５〜１０％の有機溶剤を添加して成
る養毛剤。（２）蒸溜軟水、オレフィンサルフェート、
カミツレ花抽出液、コカミドプロピル・ベタイン、グリ
セリン、ビオチン、ポリソルベート８０並びにメチル・
パラベンとから成る養毛シャンプー。 （３）植物グリセリン、アミノ酸２２００ｃｏｍｐｌｅ
ｘ、ビタミンＥ、ニコチン酸トコフェロール、タカノー
ル並びにヒアルロン酸とから成る養毛促進剤。[Scope of Claims] (1) Polysorbate 80 and polysorbate 60 are the main components, and biotin, niacin, surfactants,
A hair nourishing agent containing hyaluronic acid and 5 to 10% of an organic solvent. (2) Distilled soft water, olefin sulfate,
Chamomile flower extract, cocamidopropyl betaine, glycerin, biotin, polysorbate 80 and methyl
A hair nourishing shampoo consisting of parabens. (3) Vegetable glycerin, amino acid 2200 complete
x, vitamin E, tocopherol nicotinate, takanol, and hyaluronic acid.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP63068335A JPH01242516A (en) | 1988-03-24 | 1988-03-24 | Hair tonic, hair shampoo and hair growing promoter |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP63068335A JPH01242516A (en) | 1988-03-24 | 1988-03-24 | Hair tonic, hair shampoo and hair growing promoter |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPH01242516A true JPH01242516A (en) | 1989-09-27 |
Family
ID=13370871
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP63068335A Pending JPH01242516A (en) | 1988-03-24 | 1988-03-24 | Hair tonic, hair shampoo and hair growing promoter |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPH01242516A (en) |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1991011983A1 (en) * | 1990-02-13 | 1991-08-22 | Taisho Pharmaceutical Co., Ltd. | Novel use of alkanamidocarboxybetaine |
| WO2000048559A3 (en) * | 1999-02-19 | 2000-12-07 | Marcus R Jones | Composition for promoting hair growth comprising derivatives of vitamins and dmso |
| US6931149B2 (en) | 2002-04-19 | 2005-08-16 | Norsk Elektro Optikk A/S | Pipeline internal inspection device and method |
| JP2006513255A (en) * | 2002-10-30 | 2006-04-20 | アサト アクチェンゲゼルシャフト アプライド サイエンス アンド テクノロジー | Preparations containing melatonin, ginkgo and biotin |
| JP2009519936A (en) * | 2005-12-16 | 2009-05-21 | マレック，シェーン | Carrier composition for topical administration and therapeutic formulation containing the same |
| JP2017522310A (en) * | 2014-07-22 | 2017-08-10 | ペラケム・リミテッドＰｅｒａｃｈｅｍ Ｌｉｍｉｔｅｄ | Hair conditioning composition |
| US9962444B2 (en) | 2016-09-27 | 2018-05-08 | Shane Malek | Pharmacokinetically extended action topical hair growth formulation, and administration method |
-
1988
- 1988-03-24 JP JP63068335A patent/JPH01242516A/en active Pending
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1991011983A1 (en) * | 1990-02-13 | 1991-08-22 | Taisho Pharmaceutical Co., Ltd. | Novel use of alkanamidocarboxybetaine |
| WO2000048559A3 (en) * | 1999-02-19 | 2000-12-07 | Marcus R Jones | Composition for promoting hair growth comprising derivatives of vitamins and dmso |
| US6931149B2 (en) | 2002-04-19 | 2005-08-16 | Norsk Elektro Optikk A/S | Pipeline internal inspection device and method |
| JP2006513255A (en) * | 2002-10-30 | 2006-04-20 | アサト アクチェンゲゼルシャフト アプライド サイエンス アンド テクノロジー | Preparations containing melatonin, ginkgo and biotin |
| JP2009519936A (en) * | 2005-12-16 | 2009-05-21 | マレック，シェーン | Carrier composition for topical administration and therapeutic formulation containing the same |
| US8444960B2 (en) | 2005-12-16 | 2013-05-21 | Celmatrix Corporation | Topical administration carrier composition and therapeutic formulations comprising same |
| JP2017522310A (en) * | 2014-07-22 | 2017-08-10 | ペラケム・リミテッドＰｅｒａｃｈｅｍ Ｌｉｍｉｔｅｄ | Hair conditioning composition |
| US9962444B2 (en) | 2016-09-27 | 2018-05-08 | Shane Malek | Pharmacokinetically extended action topical hair growth formulation, and administration method |
| US10342872B2 (en) | 2016-09-27 | 2019-07-09 | Celmatrix Corporation | Pharmacokinetically extended action topical hair growth formulation, and administration method |
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