WO2012068714A1

WO2012068714A1 - Hair growth promoter

Info

Publication number: WO2012068714A1
Application number: PCT/CN2010/078935
Authority: WO
Inventors: 陈翰民
Original assignee: Chen Han-Min
Priority date: 2010-11-22
Filing date: 2010-11-22
Publication date: 2012-05-31
Also published as: JP2013540135A; KR20180080368A; KR102035812B1; KR20130060326A; JP5902184B2; KR20150136544A

Abstract

A hair growth promoter comprising adenine or salts of adenine as active agents and cosmetic carriers is disclosed. The amount of the active agents in the hair growth promoter is more than 0.0001wt%. The cosmetic carriers are lubricants, solvents, humectants or thickening agents. The hair growth promoter has the effect of stimulating hair growth, preventing hair loss and increasing growth of eyelash and eyebrow, and can be used in hair lotion, hair cleaning emulsion, hair moisture, hair care gel, hair setting lotion, shampoo and so on.

Description

Hair growth promoter

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a hair growth promoting agent, and more particularly to a hair growth promoting agent which can maintain hair growth and increase its density. BACKGROUND OF THE INVENTION As the population ages and the pressures of life increase, more and more people are facing a crisis of hair loss or baldness. According to medical research, this crisis has also caused psychological and emotional stress on the family, so most people try to find a way to effectively treat alopecia. In general, hair loss is caused by male hormones and dihydrotestosterone in hair follicles. Dihydrotestosterone reduces the blood flow of hair follicles and hair dermal papillae, making the scalp nutrient insufficient or producing an oxidation reaction, so the general hair growth formula has elimination. Or ingredients that alleviate the above symptoms, for example, plus sauerkraut extract, vitamin E and its derivatives or choline derivatives to increase blood circulation of the scalp, or add amino acids such as serine or methionine, vitamins such as B6 Wait to nourish hair follicles to prevent hair loss and promote hair growth.

The US Food and Drug Administration (FDA) proposes two components for the treatment of male alopecia, finasteride (US Patent No. 2006/0099251 A1) and minoxidil (US Patent No. 4139619). Finasteride converts free testosterone to dihydrotestosterone using a 5-alpha-reductase that inhibits activity, triggering hair follicle micronization (Dallob, 1994), which was originally used to treat benign prostatic hyperplasia (BPH) However, it was later found to be effective in treating male alopecia; minoxidil is a vasodilator that was originally an oral drug for the treatment of hypertension (Loniten), which was found in the 1980s. It can grow hair and inhibit hair loss; Puqiang has obtained FDA approval for a product containing 2% minoxidil for the treatment of alopecia and Rogaine and Regaine. The reason is due to It may cause more oxygen, blood and nutrients to enter the hair follicle by dilating blood vessels and opening potassium channels; minoxidil hair tonic is recommended to be combined with adenosine (Li, 2001) and was by A2b adenosine receptor as a way (lino, 2007), it is disclosed that adenosine also has the function of treating alopecia, but it may cause side effects, especially when minoxidil is used together with adenosine, it may cause edema, tachycardia, and difficulty breathing. , fatigue and nausea, and may lead to the formation of cancer.

Although attempts have been made to use the various methods described above, the hair spray on the face today does not necessarily have the ability to adequately prevent hair loss and promote hair growth in any area of the scalp, for example, using phenazine at the top of the head or forehead. When amines (finasteride) and minoxidil, almost only the top of the head can effectively produce hair; in addition, most of the treatment must take a long time to have an effect, for example, 4 to 6 months; treatment of baldness The disease can also be solved by transplanting hair surgery, but it will feel pain during the operation, and there is no guarantee that it will succeed. The hair even needs to wait for several months to several years before it regenerates. SUMMARY OF THE INVENTION In view of the above, an object of the present invention is to provide a hair growth promoting agent.

The present invention provides a hair growth promoting agent, the hair growth promoting agent mainly comprising: adenine or adenine salt as an active substance; and a cosmetic carrier.

As a preferred embodiment of the hair growth promoting agent described above, the hair growth promoting agent is used in combination with a cosmetic carrier by adenine or adenine salts.

As a preferred embodiment of the above hair growth promoter, the active material accounts for 0.0001% or more by weight of the hair growth promoter.

As a preferred embodiment of the above hair growth promoter, the cosmetic carrier is a lubricant, a solvent, a moisturizer, a thickener, a powder or a mixture thereof.

As a preferred embodiment of the above hair growth promoting agent, the cosmetic carrier is a hair lotion, a hair lotion, a conditioner, a hair care gel, a hair styling liquid or a shampoo.

The invention provides an eyelash and eyebrow growth promoter, wherein the eyelash and eyebrow growth promoter are composed of: adenine or adenine salt as an active substance; and a cosmetic carrier.

A preferred embodiment of the above-mentioned eyelash and eyebrow growth promoter, wherein the cosmetic carrier For hair tonic, hair lotion, conditioner, hair care gel, hair styling lotion or shampoo.

The hair loss prevention agent provided by the present invention, the hair loss prevention agent mainly comprises: adenine or adenine salt as an active substance; and a cosmetic carrier.

As a preferred embodiment of the above-mentioned hair loss preventing agent, the cosmetic carrier is a hair lotion, a hair lotion, a conditioner, a hair care gel, a hair styling solution or a shampoo.

The hair growth promoting agent of the present invention uses an adenine or an adenine salt as an active substance; and a cosmetic carrier, which can provide a hair styling water, a cleansing lotion, a moisturizing lotion, a hair care gel, and a hair which do not harm the human skin or the scalp. A styling solution or shampoo that not only stimulates hair growth, prevents hair loss, but also promotes the growth of eyelashes and eyebrows. Brief Description of the Drawings Fig. 1 is a comparison diagram of a hair dermal mastoid cell regeneration test of the present invention. BEST MODE FOR CARRYING OUT THE INVENTION In order to achieve the above objects and effects, the following description will be made in conjunction with the accompanying drawings and embodiments, so that those skilled in the art can.

Firstly, the present invention provides a hair growth promoting agent mainly comprising adenine or adenine salt as an active substance and a cosmetic carrier, and the ratio of the active substance varies depending on the formulation form and the preparation method, and the composition weight thereof The preferred range of percentage is 0.0001% or more, and the hair growth promoting agent may be present in the form of a hair lotion, a cleansing lotion, a conditioner, a hair care gel, a hair styling solution or a shampoo, and is passed through a liquid, a paste or Latex-like application to the skin or scalp; in addition, the present invention comprises a cosmetic carrier which may be a carrier of a diluent, a dispersing agent or adenine to promote the distribution of the hair growth promoting agent on the skin surface, and the carrier may be in the form of a liquid. Or a solid lubricant, a solvent, a humectant, a thickener or a powder; in addition to the active substance of the present invention and a cosmetic carrier, the hair growth promoting agent also contains additives and adjuvants commonly used in the field of cosmetics, medicine or dermatology, such as Hydrophilic or lipophilic gel, hydrophilic or lipophilic active agent, preservative, anti-resistance Agents, solvents, fragrances, fillers, For fungicides, deodorants, dyes or colorants, these additives and adjuvants are used in amounts ranging from 0.01% to 10% by weight.

In order to prove the influence of the adenine or adenine salt content on hair growth ability in the present invention, the hair growth promoter of the present invention prepares a hair growth aqueous solution of four samples by different ratios, and the proportion components thereof are as shown in Table 1, and the sample thereof Preparation methods include:

(1) mixing adenine sulfuric acid with menthol, polyethylene glycol-40, hydrogenated castor oil, ethanol, and part of the separated exchange water, and stirring to produce a solution;

(2) The remaining ion-exchanged water is further added to the above solution to form an aqueous solution of hair growth.

Table 1 Samples of raw water configuration 1-4

(a) Performing a hair growth test in mice

The above samples 1-4 were applied to mice whose hair growth cycle had been quiescent, and the mice had been shaved by scissors or a razor, and the hair of the samples 1 to 4 was applied to the back. The area where the hair was shaved was set for every ten mice, and each group was applied with a sample of 0.2 liters per day. The average value of the area of hair regeneration after 14 and 28 days was as shown in Table 2. Table 2 Results of raw water test

As a result, it can be inferred that the hair growth promoting component of the present invention has an excellent effect on hair growth.

(b) conducting a hair growth test of the human body

The invention has the effects of preventing hair loss and promoting hair growth, and the sample 3, the sample 4 and the control group of the above configuration are applied to the scalp of 60 males with alopecia, twice a day, 1 ml portion each time, continuously applying four After the month, the human body test was conducted through a questionnaire. The results of the questionnaire test are shown in Table 3.

Table 3 Test results

After 8 weeks, after 16 weeks

Sample 3 sample 4 control group sample 3 sample 4 control group

(n = 25) (n = 28) (η = Π) (n = 25) (n = 28) (η = Π) Hair type Independent group (%, percentage of the test group)

Change

+2 (improvement) 4 (16%) 5 (18%) 0 (0%) 9 (36%) 13 (47%) 0 (0%)

+1 (slightly modified 7 (28%) 13 (46%) 2 (12%) 10 (40%) 9 (32%) 1 (6%)

0 (no change) 14 (56%) 10 (36%) 8 (47%) 6 (24%) 6 (21%) 8 (47%)

-1 (Slightly evil 0 (0%) 0 (0%) 5 (29%) 0 (0%) 0 (0%) 5 (29%)

-2 (deterioration) 0 (0%) 0 (0%) 2 (12%) 0 (0%) 0 (0%) 3 (18%) Average score 0.60 0.82 -0.41 1.12 1.25 -0.59 As is apparent from the results of Table 3, the hair growth promoting agent of the present invention contains a significant adenine or adenine salt for hair growth.

(c) Configuration of cleansing lotion

For the preparation method and composition, please refer to the following and Table 4:

(c-1) separately mixing the first stage and the second stage components into a solution;

(c-2) The above solutions were further mixed to prepare a hair lotion.

Table 4 Configuring a cleansing lotion sample 5

(d) Configuration of shampoo

For the preparation method and composition, please refer to the following and Table 5:

(d-1) uniformly distributing hydroxycellulose in ion exchange water through a stirrer;

(d-2) after heating the above solution to 70 ° C, diamethylenediaminetetraacetate and sodium citrate are added until completely dissolved;

(d-3) adding the above solution to the polyquaternium 7 until completely dissolved;

(d-4) cooling the above solution to 40 ° C and then adding sodium laurosyl, lauric acid amido propylbetaine, oleic acid amine propylamine oxide (Cocamidopropylamine oxide) and lauramide ME A (Lauramide MEA) and mixed with a mouth;

(d-5) Urea, propylparaben, adenine sulfate, menthol and flavor are added to produce a shampoo.

Table 5 Configuring shampoo samples 6

(e) Performing the conditioning solution

The preparation method and composition thereof are as shown in Table 6, the ion exchange water is completely mixed with the polyquaternium 7, and then guar hydroxypropyltrimethylammonium chloride, dimethyl copolyol, adenine sulfate and perfume are added. Produce a lotion. Table 6 Configure Run Condition Sample 7

(f) Configuration of eyebrow and eyelash cleansing lotion

For the preparation method and composition, please refer to the following and Table 7:

(f-1) mixing the first stage and the second stage components separately into a solution;

(f-2) The above solution is further mixed to form an eyebrow and eyelash cleansing lotion.

Table 7 Configure eyebrow and eyelash cleansing lotion samples 8 and 9

(g) Human body test for eyelash cleansing lotion

The eyelash cleaning lotion of the present invention is tested by a questionnaire method for human body testing. The test object is to apply the sample 8, sample 9 and control group 2 of the above configuration to the eyelashes of 48 women through a cotton swab, once a day, 0.5 ml portion each time, after three months of continuous application, the questionnaire test results are shown in the table. 8 is shown.

Table 8 Test results

As is apparent from the results of Table 8, the components of the eyelash cleansing lotion of the present invention contain adenine or adenine salts and have remarkable effects on eyelash growth.

(h) Human body testing of eyebrow cleansing lotion

The eyebrow cleaning lotion of the present invention is subjected to a human body test investigation through a questionnaire method, and the test object is to apply the sample 8, sample 9 and the control group 2 arranged above to the eyelashes of 60 women by a cotton swab, once a day, The results of the questionnaire test are shown in Table 9 after 0.5 ml of each dose and two months of continuous application. Table 9 Test results

As is apparent from the results of Table 9, the components of the eyebrow cleansing lotion of the present invention contain adenine or adenine salts, and have remarkable effects on eyelash growth.

(i) Human hair dermal papilla cell regeneration test

The effect of cell regeneration by adenine can be measured by measuring the number of dermal dermal protuberance cells in human hair, comparing the effects of adenosine and minoxidil (minoxidil) under the following conditions. The results are shown in Figure 1; The cell culture medium of hair dermal protuberance cells contains adenine, adenosine and minoxidil (minoxidil), and the composition contains 0.002% adenine, adenosine and minoxidil (minoxidil). The test method is:

(i-1) formulating 0.002% adenine, adenosine, and minoxidil, and controlling the medium for measuring dermal dermal protuberance cells;

(i-2) implanting human hair dermal papilla cells into a 96-well culture dish at a density of 5000 cells/cell, and adding 0.1 ml of the culture solution to each of the culture dishes;

(i-3) After the cells were implanted for 12, 24, 36, 48 and 60 hours, a visual counter was used to calculate the number of all cells;

(i-4) As can be seen from the results of Fig. 1, adenine can significantly enhance the dermal dermal prominent cells of human hair. The hair growth promoting agent of the present invention has a remarkable hair care effect, can improve the hair growth ability of humans or mammals, and can prevent hair from falling off.

In the above, the above is only the preferred embodiment of the present invention, and the scope of the patent protection of the present invention is not limited thereto, and the scope of the invention should be determined by the content of the claims.

Claims

Claim

A hair growth promoting agent, characterized in that the hair growth promoting agent mainly comprises: an adenine or an adenine salt as an active substance; and a cosmetic carrier.

The hair growth promoting agent according to claim 1, wherein the hair growth promoting agent is mixed with a cosmetic carrier by adenine or adenine salts.

The hair growth promoting agent according to claim 1, wherein the active material accounts for 0.0001% or more by weight of the hair growth promoter.

The hair growth promoting agent according to claim 1 or 3, wherein the cosmetic carrier is a lubricant, a solvent, a moisturizer, a thickener, a powder or a mixture thereof.

The hair growth promoting agent according to claim 1, wherein the cosmetic body is a hair lotion, a hair lotion, a hair lotion, a hair care gel, a hair styling liquid or a shampoo.

6. An eyelash and eyebrow growth promoter, characterized in that the composition of the eyelash and eyebrow growth promoter is: adenine or adenine salt as an active substance; and a cosmetic carrier.

The eyelash and eyebrow growth promoter according to claim 6, wherein the cosmetic carrier is a hair lotion, a hair lotion, a conditioner, a hair care gel, a hair styling solution or a shampoo.

A hair loss preventing agent, characterized in that the hair loss preventing agent mainly comprises: adenine or an adenine salt as an active material; and a cosmetic carrier.

The hair loss preventing agent according to claim 8, wherein the cosmetic carrier is a hair lotion, a hair lotion, a conditioner, a hair care gel, a hair styling solution or a shampoo.

12

Correction page (Article 91)