KR102035812B1 - Hair growth promoter - Google Patents

Abstract

The present invention relates to a hair growth promoter, and includes an active material of adenine or adenine salts and a cosmetic carrier. The active substance accounts for more than 0.0001% of the component substance percentage, and the cosmetic carrier can be applied to related products such as hair regrowth, hair clean lotion, rinse, conditioner, hair spray or shampoo as lubricant, solvent, moisturizer or thickener. . The present invention stimulates silk hair growth and has the effect of preventing hair loss, as well as promoting eyelash and eyebrow growth.

Description

Hair Growth Promoter {HAIR GROWTH PROMOTER}

The present invention relates to a kind of hair growth promoter, and in particular, refers to a kind of hair growth promoter that maintains a kind of hair growth and increases its density.

As the aging and living stresses of the modern population increase day by day, more and more people are facing hair loss or baldness. Based on medical research, this crisis also creates psychological and emotional stress at home, so most people are looking for ways to effectively treat baldness. In general, hair loss is caused by male hormones and dihydrotestosterone in the hair follicles. Dihydrotestosterone reduces the blood flow of hair follicles and papillary papillary process of hair follicles, causing scalp nutrients and oxidative reactions. Therefore, general hair restorer slurries contain ingredients that eliminate or alleviate the above symptoms. For example, sugar extracts, vitamin E and its derivatives or phosphatidylcholine derivatives can be added to increase the blood circulation of the scalp or nutrients to hair follicles, amino acids such as sane or methionine, and vitamins such as B6 to prevent hair loss. And promote hair growth.

The US Food and Drug Administration (FDA) has suggested two ingredients to treat male baldness, finasteride (US Patent No. 2006/0099251 A1) and minoxidil (US Patent No. 4139619), respectively. Is to convert free testosterone to dihydrotestosterone using activated 5 alpha reductase suppression, causing hair follicle miniaturization (Dallob, 1994), which was originally intended to treat benign prostatic hyperplasia (BHP), but later to treat male baldness. Minoxidil was a type of vasodilator, originally an oral drug for the treatment of hypertension (Loniten), but the side effects of the 1980s were found to inhibit hair growth and hair loss. Baldness and hair loss with FDA approval Launched a product that contains 2% minoxidil, an effective treatment for rogaine and regaine, because it allows more oxygen, blood and nutrients to enter the hair follicle through vasodilation and potassium channel opening. Minoxidil hair regrowth is recommended for use with adenosine (Li, 2001), and A2b adenosine can be used as a receptor pathway (Iino, 2007), so adenosine also has the ability to treat baldness. However, side effects can occur, especially when minoxidil and adenosine are used together, resulting in faster edema and heart rate, shortness of breath, fatigue and nausea, and even carcinogenesis.

Although the various methods described above have been used, the hair regrowth on the market is not yet effective enough to prevent hair loss and promote hair growth in any area of the scalp. For example, the use of finasteride and minoxidil on the parietal or forehead has a growth effect on almost parietal hair. In addition, most treatments are only effective after a long time, for example, four to six months is required. Bald symptomatic treatment can also solve the problem through hair transplantation, but there is pain during the procedure, and it does not necessarily guarantee success, and even after months or years, the hair is regenerated.

1.US 2006/0099251 A1 2.US 4139619

In view of these points, an object of the present invention is to provide a kind of hair growth promoter.

The present invention provides a kind of hair growth promoter, wherein the hair growth promoter described above is an active substance of adenine or adenine salts, and a cosmetic carrier.

As an optimization method of the kind of hair growth promoter described above, the hair growth promoter described above is used in admixture with a cosmetic carrier through adenine or adenine salts.

As an optimization method of the kind of hair growth promoter described above, the above-mentioned activating material accounts for at least 0.0001% and less than 0.05% of the hair growth accelerator weight percentage.

As an optimization method of the kind of hair growth promoter mentioned above, the above-mentioned cosmetic carrier is a lubricant, a solvent, a moisturizer, a thickener, a powder, or its mixture.

As an optimization method of the kind of hair growth promoter described above, the above-mentioned cosmetic carriers are hair regrowth, hair clean lotion, rinse, conditioner, hair spray or shampoo.

The present invention provides a kind of eyelash and eyebrow growth accelerator, the active material of adenine or adenine salts as a component of the eyelash and eyebrow growth promoter described above; And cosmetic carriers.

As an optimization method of the above-described types of eyelashes and eyebrow growth promoters, the above-mentioned cosmetic carriers are hair regrowth, hair clean lotion, rinse, conditioner, hair spray or shampoo.

The present invention provides a kind of hair loss preventing agent, and the aforementioned hair loss preventing agent includes an active substance of adenine or adenine salts, and a cosmetic carrier.

As the above-mentioned optimization method of the anti-hair loss agent of the kind, the above-mentioned cosmetic carrier is a hair regrowth liquid, a hair clean lotion, a rinse, a conditioner, a hair spray, or a shampoo.

The hair growth promoter of the present invention is used as an active substance through adenine or adenine salts, and provides a cosmetic carrier, hair regrowth that does not harm human skin or scalp, hair clean lotion, rinse, conditioner, hair spray or shampoo. It not only stimulates hair growth and prevents hair loss, but also promotes eyelash and eyebrow growth.

1 is a comparative diagram of the hair dermal dermal papilla regeneration test of the present invention.

In order to achieve the above object and effect, it will be described through the following drawings and examples, to enable those skilled in the art to practice the present invention based on the following description.

First, a kind of hair growth promoter provided by the present invention includes an active substance of adenine or adenine salt and a cosmetic carrier, and the ratio of the active substance varies depending on the compounding form and production method, and the relatively good range of the weight percentage of the component is 0.0001. More than% and less than 0.05%. The hair growth promoter may be in the form of hair regrowth, hair clean lotion, rinse, conditioner, hair spray or shampoo, and may be applied to the skin or scalp through liquids, creams, or lotions. In addition, the cosmetic carrier included in the present invention may be a diluent, a dispersant or a carrier of adenine, and promotes the distribution of the components of the hair growth promoter on the surface of the skin on an average, and the form of the carrier is a liquid or a solid lubricant, a solvent, a humectant. It may be a thickener or a powder. In addition to the active substances and cosmetic carriers of the present invention, hair growth promoters may be used in cosmetics, drugs, skin, such as hydrophilic or lipophilic gels, hydrophilic or lipophilic active agents, preservatives, antioxidants, solvents, flavorings, fillers, fungicides, deodorants, dyes and coloring agents, and the like. Additives and auxiliaries commonly used in the art may also be included and the range of use of these additives and auxiliaries is from 0.01% to 10% of the total weight percentage.

In order to prove the influence on the hair growth effect of the adenine or adenine salt content in the present invention, the hair growth promoter of the present invention made four samples of aqueous solution of hair growth through various ratio combinations, the component ratios are shown in Table 1, The sample formulation method includes:

(1) Mix adenine sulfate with menthol, polyethylene glycol-40, hydrogenated castor oil, ethanol and a portion of ionic water to make a solution.

(2) The remaining ion-exchanged water is further added to the above-described solution to form an aqueous hair growth solution.

(a) Conduct hair growth test on mice

Samples 1-4 described above were applied to the body of mice in which the hair growth cycle had already been stopped and tested. These mice have already shaved off their back with scissors or a razor, and then applied sample hairs from samples 1 to 4 on their backs. Ten mice were used as a group, and 0.2 milliliter doses were applied once daily in each group, and the average value of the hair regeneration zone ratio after 14 and 28 days is shown in Table 2.

As can be seen from the results of Table 2, samples 2, 3, and 4 with the addition of adenine sulphate show a more pronounced effect than sample 1, indicating that the hair growth promoter component of the present invention has a very excellent effect on hair growth. have.

(b) Conduct hair growth test on the human body

The present invention has a hair loss prevention and hair growth promoting effect, and the combination of the sample 3, sample 4 and the control group was applied to the scalp of 60 men with bald symptoms. Twice a day, 1ml each time for a continuous four months after applying a human test survey was conducted, the survey test results are shown in Table 3.

As can be seen from the results in Table 3, the hair growth promoter of the present invention contains adenine or adenine salts having a distinct therapeutic effect on hair growth.

(c) Blend hair clean lotion.

See below and Table 4 for their preparation methods and components.

(c-1) The first step and the second component are respectively mixed to form a solution.

(c-2) The above-mentioned solution mixture is made into hair clean lotion.

(d) Formulate shampoo

See below and Table 5 for their preparation methods and components.

(d-1) The hydroxycellulose is uniformly distributed in the ion exchange water with a stirrer.

(d-2) After heating the above-mentioned solution to 70 degreeC, ethylene diamine tetra acetate disodium salt and sodium citric acid are added until it melt | dissolves completely.

(d-3) Polyquaternium-7 is added to the solution described above until it is completely dissolved.

(d-4) After cooling the above-mentioned solution to 40 ° C, sodium laurosyl, sodium laurosyl, lauric acid amido propylbetaine, cocamidopropylamine oxide And lauramide MEA are added and mixed.

(d-5) Add urea, propylparaben, adenine sulfate, menthol and flavoring to make a shampoo.

(e) Rinse formulation

The preparation method and components are shown in Table 6. After thoroughly mixing ion-exchanged water and polyquaternium-7, rinse is added by adding guarhydroxypropyltrimonium chloride, dimethicone copolyol, adenine sulfate and flavoring.

(f) Apply eyebrow and eyelash clean lotion.

See below and Table 7 for their preparation methods and components.

(f-1) A solution is prepared by mixing the first and second components, respectively.

(f-2) Again, the above solution is mixed to make eyebrow and eyelash clean lotion.

(g) human body test of eyelash clean lotion

The eyelash clean lotion of the present invention was subjected to a human test investigation by the following survey method, and the test was performed once a day with a swab of the sample 8, 9, and the control group 2 of the above-described combination on the eyelashes of 48 women to be tested. 0.5 ml dose was applied for 3 consecutive months, and the results of the questionnaire test are shown in Table 8.

As can be seen from the results in Table 8, the components of the eyelash clean lotion of the present invention contain adenine or adenine salts which have a distinct effect on eyelash growth.

(h) Human body test of eyebrow clean lotion

The eyebrow clean lotion of the present invention was subjected to a human body test by the following questionnaire method, and the test was performed once a day with a swab of the sample 8, 9 and the control group 2 of the above-described combination on the eyebrows of 60 women to be tested. 0.5 ml dose was applied for 2 consecutive months, and the results of the questionnaire test are shown in Table 9.

As can be seen from the results of Table 9, the components of the eyebrow clean lotion of the present invention contain adenine or adenine salts that have a distinct effect on eyebrow growth.

(i) Hair dermal papillary dendritic cell regeneration test

The cell renewal effect of adenine can be used to estimate the number of human dermal papillary dendritic cells. The action of adenosine and minoxidil (minoxidil) was compared under the following conditions, and the results are shown in Table 1. Adenine, adenosine and minoxidil (minoxidil) contained in the cell cultures of hair dermal papillary dendritic cells were measured and contained 0.002% of adenine, adenosine and minoxidil (minoxidil), and the measuring method was as follows:

(i-1) 0.002% of adenine, adenosine and minoxidil are combined to control the media of hair dermal papillary dendritic cells.

(i-2) Human hair dermal papillary dendritic cells are transplanted into 96 cells of a culture dish, the density of which is 5000 cells / cell, and 0.1 ml of the culture solution is added to the culture dish of each cell.

(i-3) After 12, 24, 36, 48 and 60 hours of transplantation cells, count the quantity of all cells again with the visual counter.

(i-4) As can be seen from the results of Fig. 1, since the adenine significantly improves the regeneration ability of human hair dermal papillary dendritic cells, the hair regeneration promoter of the present invention has a distinct hair care effect, which leads to humans and mammals. Can improve hair growth ability and prevent hair loss.

In summary, this is a comparatively good embodiment of the present invention, which is not limited to the claims of the present invention, and the claims of the present invention are based on the contents of the claims.

Claims (6)

As a hair growth promoter,
As the only active ingredient effective for promoting hair growth, adenine or adenine salts; And a cosmetic carrier;
The content of the active ingredient based on the weight of the hair growth promoter is within the range between 0.002% and 0.01% by weight,
Hair growth promoter. The hair growth promoter of claim 1, wherein the hair growth promoter is used in admixture with the cosmetic carrier through adenine or adenine salts. The hair growth promoter according to claim 1, wherein the cosmetic carrier is a lubricant, a solvent, a humectant, a thickener, a powder, or a mixture thereof. The hair growth promoter of claim 1, wherein the cosmetic carrier is a hair regrowth, hair clean lotion, rinse, conditioner, hair spray or shampoo. As eyelash and eyebrow growth promoter,
As the only active ingredient effective for promoting eyelash and eyebrow growth, adenine or adenine salts; And a cosmetic carrier;
The content of the active ingredient based on the weight of the eyelashes and eyebrow growth promoter is within the range between 0.002% and 0.01% by weight,
The cosmetic carrier is a hair regrowth, hair clean lotion, rinse, conditioner, hair spray or shampoo,
Eyelash and Eyebrow Growth Accelerators. As a hair loss prevention agent,
As the only active ingredient effective in preventing hair loss, adenine or adenine salts; And a cosmetic carrier;
The content of the active ingredient based on the weight of the hair loss preventing agent is within a range between 0.002% and 0.01% by weight,
The cosmetic carrier is a hair regrowth, hair clean lotion, rinse, conditioner, hair spray or shampoo,
Hair loss prevention agent.

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