KR20180080368A - Hair growth promoter - Google Patents

Abstract

The present invention relates to hair growth promoters, and includes active substances of adenine and adenine salts and cosmetics carriers. The above-mentioned active substance occupies 0.0001% or more of the constituent material percentage, and the cosmetic carrier may be applied to related products such as a lubricant, a solvent, a moisturizing agent or a thickening agent, a hair cleansing liquid, a hair cleansing lotion, a conditioner, a hair spray or a shampoo . The present invention stimulates non-hair growth and has an effect of preventing hair loss, as well as promoting eyelash and eyebrow growth.

Description

Hair Growth Promoter {HAIR GROWTH PROMOTER}

The present invention relates to a hair growth promoter, and more particularly, to a hair growth promoter that maintains a kind of hair growth and increases its density.

As the aging of the modern population and stress in life are increasing day by day, more and more people are facing the crisis of hair loss or baldness. Based on medical research, this crisis creates psychological and emotional stress in the home, so most people are looking for ways to effectively treat the symptoms of baldness. In general, hair loss is caused by dihydrotestosterone in male hormones and hair follicles, and dihydrotestosterone reduces the blood flow of hair follicles and dermal papillary dendrites, resulting in lack of scalp nutrients or oxidation. Therefore, general hair growth defects include components that eliminate or alleviate the aforementioned symptoms. For example, it is possible to add hair extracts, vitamin E and its derivatives, or phosphatidyl choline derivatives to increase blood circulation in the scalp, or to supplement hair follicles with amino acids such as sine or methionine, vitamins such as B6 And promotes hair growth.

The US Food and Drug Administration (FDA) has proposed two ingredients that can treat the symptoms of male baldness: finasteride (US Patent 2006/0099251 A1) and minoxidil (US Patent No. 4139619). Finasteride (Dallob, 1994), which was originally intended for the treatment of benign prostatic hyperplasia (BHP), but was later used to treat male baldness symptoms Minoxidil, a kind of vasodilator, was originally an oral drug for the treatment of hypertension (Loniten), but found its side effects in hair growth and hair loss inhibition in the 1980s. FDA approval for baldness symptoms and hair loss It has been shown that 2% minoxidil effectively treats Rogaine and Regaine, because oxygen, blood, and nutrients enter the hair follicle through vascular enlargement and potassium channel opening Minoxidil is recommended for use with adenosine (Li, 2001), and A2b adenosine may be used as a receptor pathway (Iino, 2007), so adenosine also has the ability to treat baldness However, side effects may occur, especially when minoxidil and adenosine are used together, causing edema, heart beat, dyspnea, fatigue and nausea, and may cause cancer.

Although the above-mentioned various methods have been used, the presently-marketed hair follicle does not yet have the effect of preventing hair loss and promoting hair growth sufficiently in any part of the scalp. For example, when finasteride and minoxidil are used in the crown and forehead, growth of only the hair of the crown almost grows. In addition, most treatments are effective only after prolonged periods of time, such as four to six months. Baldness symptoms can also be solved through hair transplant surgery, but there is pain during the procedure, and there is no guarantee of success, and even after months or years, the hair is regenerated.

1.US 2006/0099251 A1 2.US 4139619

In view of these points, an object of the present invention is to provide a hair growth promoter.

The present invention provides a kind of hair growth promoting agent, and the above hair growth promoting agent is active substance of adenine or adenine salt, and cosmetic carrier.

As a method for optimizing the above-mentioned hair growth promoting agent, the hair growth promoting agent mentioned above is used by mixing with a cosmetic carrier through adenine or adenine salts.

As a method for optimizing a hair growth promoter as described above, the above-mentioned activating materials occupy from 0.0001% to less than 0.05% of the weight percentage of the hair growth promoter.

As a method for optimizing the hair growth promoter, the above-mentioned cosmetic carrier is a lubricant, a solvent, a moisturizer, a thickener, a powder or a mixture thereof.

As the above-mentioned optimization methods of the hair growth promoting agent, the above-mentioned cosmetic carrier is a hair growth liquid, a hair cleansing lotion, a rinse, a conditioner, a hair spray or a shampoo.

The present invention provides a kind of growth promoting agent for eyelashes and eyebrows, which is an active substance of adenine or adenine salt, which is a component of the eyelashes and eyebrows growth promoting agents described above; And a cosmetic carrier.

The above-mentioned cosmetic carrier is a hair growth liquid, a hair cleansing lotion, a rinse, a conditioner, a hair spray, or a shampoo as an optimization method of the above-mentioned eyelashes and eyebrow growth promoters.

The present invention provides a kind of hair loss preventing agent, and the above-mentioned hair loss preventing agent includes an active substance of adenine or adenine salt, and a cosmetic carrier.

The above-described cosmetic carrier is a hair growth solution, a hair cleansing lotion, a rinse, a conditioner, a hair spray or a shampoo.

The hair growth promoter of the present invention is used as an active substance through adenine or adenine salts, and provides a cosmetic carrier, a hair cleansing solution which does not harm human skin or scalp, a hair cleansing lotion, a conditioner, a hair spray or a shampoo Not only does it stimulate hair growth and prevents hair loss, it also has the effect of promoting eyelash and eyebrow growth.

BRIEF DESCRIPTION OF THE DRAWINGS Fig. 1 is a comparative chart of the hair dermal amylase cell regeneration test of the present invention.

In order to achieve the above objects and effects, the following description of the embodiments and drawings will be made by those of ordinary skill in the art in view of the following description.

First, the hair growth promoter of the present invention includes an active substance of adenine or adenine salt and a cosmetic carrier. The proportion of the active substance varies depending on the form and the preparation method, and a relatively excellent range of the component weight percentage is 0.0001 % To less than 0.05%. The hair growth promoting agent can be present in the form of hair growth liquid, hair cleansing lotion, rinse, conditioner, hair spray or shampoo, and can be applied to skin or scalp through liquid, cream or lotion. The cosmetic carrier of the present invention may be a diluent, a dispersing agent or a carrier of adenine, and promotes the components of the hair growth promoter to be distributed on the surface of the skin on an average basis. The carrier may be in the form of liquid or solid lubricant, , Thickener or powder. In addition to the active substance of the present invention and the cosmetic carrier, the hair growth promoting agent may be a cosmetic, a medicament, a skin or the like such as a hydrophilic or lipophilic gel, a hydrophilic or a lipophilic active agent, a preservative, an antioxidant, a solvent, a fragrance, a filler, a disinfectant, Additives and adjuvants commonly used in the field, and the range of use of such additives and adjuvants is from 0.01% to 10% of the total weight percentage.

In order to demonstrate the influence of the adenine or adenine salt content in the present invention on the hair growth effect, the hair growth promoter of the present invention produced 4 samples of the hair growth aqueous solution through various ratios, The sample formulation method includes:

(1) A solution is prepared by mixing adenine sulfate with menthol, polyethylene glycol-40, hydrogenated castor oil, ethanol and a part of ionic water.

(2) The remaining ion-exchanged water is again added to the above-mentioned solution to make a hair growth aqueous solution.

(a) Performing a hair-growth test on mice

The above-mentioned Samples 1-4 were tested by applying them to the body of a mouse in which the hair growth cycle had already been stopped. These mice had already shaved their hair with scissors or razors, and then applied the hair of the samples 1 to 4 on the back of the hair, A total of 0.2 milliliters of the sample was applied once a day to each group of 10 mice, and the average value of the hair regeneration zone ratios after 14 days and 28 days was as shown in Table 2.

As can be seen from the results shown in Table 2, samples 2, 3 and 4 to which adenosine sulfate was added exhibited a distinctive effect as compared with Sample 1, indicating that the hair growth promoter component of the present invention had a very excellent effect on hair growth. have.

(b) Performing a human hair growth test

The present invention has the effect of preventing hair loss and promoting hair growth. Samples 3 and 4 thus prepared and the control group were applied to the scalp of 60 men with baldness symptoms. The results of the questionnaire test were as shown in Table 3. The results of the questionnaire test were as follows.

As can be seen from the results in Table 3, the hair growth promoter of the present invention contains adenine or adenine salts having a distinct therapeutic effect on hair growth.

(c) Combine hair cleansing lotion.

The preparation methods and components are described below and in Table 4.

(c-1) The first step and the second component are mixed together to form a solution.

(c-2) The above-mentioned solution mixture is made into a hair cleansing lotion.

(d) Conduct the formulation of the shampoo

The manufacturing method and components thereof are shown below and in Table 5.

(d-1) Hydroxycellulose is uniformly distributed in the ion exchange water with a stirrer.

(d-2) The above-mentioned solution is heated to 70 占 폚, and then ethylenediaminetetraacetic acid disodium salt and sodium citrate are added until completely dissolved.

(d-3) Polyquaternium-7 is added to the above solution until it is completely dissolved.

(d-4) After cooling the above-mentioned solution to 40 占 폚, sodium laurosyl, lauric acid amido propylbetaine, cocamidopropylamine oxide, And lauraamide MEA (Lauramide MEA) are added and mixed.

(d-5) urea, propylparaben, adenine sulfate, menthol and fragrance to make a shampoo.

(e) Conduct rinse formulation

Table 6 shows the production method and components. After the ion-exchange water and polyquaternium-7 are thoroughly mixed, a rinse is made by adding guar hydroxypropyltrimonium chloride, dimethicone copolyol, adenosine sulfate and flavoring.

(f) Apply eyebrow and eyelashes clean lotion.

The preparation method and components are described below and in Table 7.

(f-1) A solution is prepared by mixing the first step and the second step components, respectively.

(f-2) Again, make eyebrows and eyelashes clean lotion by mixing the above solutions.

(g) Human eyelash clean lotion test

The eyelash clean lotion of the present invention was subjected to a human body test by the following survey method. The test was performed on 48 eyelashes of women to be tested, sample 8, sample 9 and control group 2, 0.5 ml volume was applied for 3 consecutive months, and the results of the questionnaire test are shown in Table 8.

As can be seen from the results in Table 8, the components of the eyelash clean lotion of the present invention contain adenine or adenine salts having a pronounced effect on eyelash growth.

(h) Human eye test of eyebrow clean lotion

The eyebrow clean lotion of the present invention was subjected to a human body test by the following survey method. The test was performed on the eyebrows of 60 female subjects to be tested by using the sample 8, sample 9 and control group 2 described above, 0.5 ml was continuously applied for 2 consecutive months, and the results of the questionnaire test are shown in Table 9.

As can be seen from the results in Table 9, the components of the eyebrow clean lotion of the present invention contain adenine or adenine salts having a noticeable effect on eyebrow growth.

(i) Hair dermal papillary dendritic cell regeneration test

Adenine-enhancing cell regeneration effects can quantify the number of human dermal papillary dendritic cells. The effects of adenosine and minoxidil (minoxidil) were compared under the following conditions, and the results are shown in Table 1. Adenosine and minoxidil (minoxidil) contained in the cell culture medium of hair dermal papillary prominent dendritic cells were measured, and 0.002% of adenine, adenosine and minoxidil (minoxidil) were contained in the components.

(i-1) 0.002% of adenine, adenosine and minoxidil are mixed, and the medium of dermal papillary dendritic cells is controlled and measured.

(i-2) Human hair dermal papillary dendritic cells are each transplanted into 96-well culture dishes, each of which has a density of 5000 cells / cell, and 0.1 ml of culture medium is added into the culture dish of each cell.

(i-3) After transplanted cells 12, 24, 36, 48 and 60 hours, calculate the quantity of all cells with a visual counter again.

(i-4) As can be seen from the results of FIG. 1, since adenine significantly improves the ability of human dermal papillary dendritic cells to regenerate, the hair regrowth promoter of the present invention has a remarkable hair care effect, The hair growth ability of the hair can be improved and hair loss can be prevented.

It will be understood by those of ordinary skill in the art that various changes in form and detail may be made therein without departing from the spirit and scope of the invention as defined by the appended claims.

Claims (6)

As a composition for use in promoting hair growth in hair follicles of a scalp in a human in need thereof,
Adenine or adenine salts as sole active ingredients effective in promoting hair growth; And a cosmetic carrier,
Wherein the single active ingredient is present in an amount ranging from 0.002% to 0.01% by weight, based on the weight of the composition.
Composition. The composition of claim 1, wherein the composition is used by admixing with the cosmetic carrier through adenine or adenine salts. The composition according to claim 1, wherein the cosmetic carrier is a lubricant, a solvent, a moisturizer, a thickener, a powder or a mixture thereof. The composition according to claim 1, wherein the cosmetic carrier is a hair growth liquid, a hair cleansing lotion, a rinse, a conditioner, a hair spray or a shampoo. A composition for use in promoting eyelash and eyebrow growth in eyelashes and eyebrow hair follicles in a human in need thereof,
Adenine or adenine salts as sole active ingredients effective in promoting eyelash and eyebrow growth; And a cosmetic carrier,
Wherein said single active ingredient is included in an amount within the range of between 0.002 wt% and 0.01 wt% based on the weight of the composition,
Wherein the cosmetic carrier is a hair growth liquid, a hair cleansing lotion, a rinse, a conditioner, a hair spray or a shampoo,
Composition. As a composition for use in preventing hair loss in hair follicles of a scalp in a human in need thereof,
Adenine or adenine salts as sole active ingredients effective in preventing hair loss; And a cosmetic carrier,
Wherein said single active ingredient is included in an amount within the range of between 0.002 wt% and 0.01 wt% based on the weight of the composition,
Wherein the cosmetic carrier is a hair growth liquid, a hair cleansing lotion, a rinse, a conditioner, a hair spray or a shampoo,
Composition.

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