CN112402295A - Composition for promoting eyelash growth and application thereof - Google Patents
Composition for promoting eyelash growth and application thereof Download PDFInfo
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- CN112402295A CN112402295A CN202011385769.1A CN202011385769A CN112402295A CN 112402295 A CN112402295 A CN 112402295A CN 202011385769 A CN202011385769 A CN 202011385769A CN 112402295 A CN112402295 A CN 112402295A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/88—Polyamides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
- A61K8/442—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof substituted by amido group(s)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
- A61K8/4913—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having five membered rings, e.g. pyrrolidone carboxylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/606—Nucleosides; Nucleotides; Nucleic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q7/00—Preparations for affecting hair growth
Abstract
The invention discloses a composition for promoting eyelash growth, which comprises the following components in parts by weight: 0.05-0.3 part of sodium hyaluronate, 0.2-1.2 parts of sodium polyaspartate, 0.2-2 parts of compound amino acid, 0.005-0.1 part of pyridoxine HCl, 0.005-0.1 part of adenosine, 0.2-1 part of skin conditioner, 0.005-1 part of myristoyl pentapeptide-40.0001 and 0.005-0.2 part of menthol; the skin conditioning agent is a mixture of 1, 2-pentanediol and 4-tert-butylcyclohexanol. The composition can provide required nutrient components for the growth of eyelashes, activate the expression of keratin genes, promote the thickening, lengthening and thickening of the eyelashes, has safe and mild components, no irritation to eyes, no discomfort during the use process and quick response.
Description
Technical Field
The invention belongs to the technical field of cosmetics, and particularly relates to a composition for promoting eyelash growth and application thereof.
Background
Eyelashes are hairs growing on the edge of eyelids, and have physiological functions of blocking foreign materials, protecting eyeballs and cornea. According to modern aesthetic standards, growing and voluminous eyelashes are the beauty marks, and therefore, beauty lovers often temporarily make the eyelashes thicker and thicker by using mascara or sticking false eyelashes. However, eyelashes, which are one of the most fragile organs of the human body, have strong rejection to foreign substances, and thus, the use of mascara or false eyelashes often cause discomfort to the eyes. In addition, mascara typically contains more chemicals, often causes damage to the eyelashes, and in addition, after use, the mascara needs to be cleaned with a makeup removal product, resulting in the eyelashes becoming dry, broken, and less numerous.
For this reason, there are many products on the market that claim to promote eyelash growth, and then many products have irritation, cause irritation to eyes when used, and have poor effect of promoting eyelash growth.
Disclosure of Invention
In order to solve the defects in the prior art, the invention aims to provide a composition for promoting eyelash growth and an application thereof.
In order to achieve the purpose, the technical scheme adopted by the invention is as follows:
the composition for promoting eyelash growth comprises the following components in parts by weight: 0.05-0.3 part of sodium hyaluronate, 0.2-1.2 parts of sodium polyaspartate, 0.2-2 parts of compound amino acid, 0.005-0.1 part of pyridoxine HCl, 0.005-0.1 part of adenosine, 0.2-1 part of skin conditioner, 0.005-1 part of myristoyl pentapeptide-40.0001 and 0.005-0.2 part of menthol; the skin conditioning agent is a mixture of 1, 2-pentanediol and 4-tert-butylcyclohexanol.
In the formula of the composition, the sodium hyaluronate plays a role in moisturizing and film forming, the sodium polyaspartate plays a role in moisturizing and fatigue relieving, and the two components can moisten hair roots and improve eyelash growth environment; the skin conditioner and menthol have the function of relieving and can relieve discomfort generated in the eyelash growth process; the myristoyl pentapeptide-4 has the effect of promoting eyelash growth, and the effect of promoting eyelash growth can be obviously improved by compounding the myristoyl pentapeptide-4 with adenosine and compound amino acid.
Preferably, the composition for promoting eyelash growth comprises the following components in parts by weight: 0.1 part of sodium hyaluronate, 0.5 part of polyaspartic acid sodium, 1 part of compound amino acid, 0.02 part of pyridoxine HCl, 0.02 part of adenosine, 0.3 part of skin conditioner, 40.1 parts of myristoyl pentapeptide and 0.01 part of menthol. Tests prove that the composition has a good effect of promoting eyelash growth under the formula.
Preferably, the compound amino acid includes at least two of serine, alanine, glycine, glutamic acid, lysine HCl, threonine, arginine, and proline.
Preferably, the compound amino acid comprises the following components in percentage by weight: 26.87% of betaine, 9.75% of sodium pyrrolidone carboxylate (PCA-Na), 3.78% of pyrrolidone carboxylic acid, 5% of calcium lactate, 1.12% of serine, 1.06% of alanine, 1% of glycine, 0.43% of glutamic acid, 0.34% of lysine HCl, 0.32% of threonine, 0.29% of arginine, 0.04% of proline, 25% of trehalose and the balance of water. Experiments prove that the compound amino acid, the myristoyl pentapeptide-4 and the adenosine in the formula are compounded for use, so that the effect of the composition on promoting the growth of eyelashes is remarkably improved.
Preferably, the skin conditioner comprises the following components in percentage by weight: 70% of 1, 2-pentanediol and 30% of 4-tert-butylcyclohexanol.
As another aspect of the present invention, the present invention also provides the use of the composition for promoting eyelash growth in cosmetics.
As another aspect of the present invention, the present invention also provides a cosmetic comprising the composition for promoting eyelash growth.
Preferably, the composition for promoting eyelash growth comprises the following components in percentage by weight in the cosmetic: 0.05-0.3% of sodium hyaluronate, 0.2-1.2% of polyaspartic acid sodium, 0.2-2% of compound amino acid, 0.005-0.1% of pyridoxine HCl, 0.005-0.1% of adenosine, 0.2-1% of skin conditioner, 0.005-1% of myristoyl pentapeptide-40.0001 and 0.005-0.2% of menthol. Under the formula, the cosmetic has a good effect of promoting eyelash growth, does not stimulate eyes, and also has the effects of relieving and moistening hair roots.
Preferably, the composition for promoting eyelash growth comprises the following components in percentage by weight in the cosmetic: 0.1% of sodium hyaluronate, 0.5% of sodium polyaspartate, 1% of compound amino acid, 0.02% of pyridoxine HCl, 0.02% of adenosine, 0.3% of skin conditioner, 40.1% of myristoyl pentapeptide and 0.01% of menthol. With the formula, the cosmetic has the best effect on promoting eyelash growth, does not stimulate eyes, and has the effects of relieving and moistening hair roots.
Compared with the prior art, the invention has the beneficial effects that: the composition can provide required nutrient components for the growth of eyelashes, activate the expression of keratin genes, promote the thickening, lengthening and thickening of the eyelashes, has safe and mild components, no irritation to eyes, no discomfort during the use process and quick response.
Detailed Description
The technical solutions of the present invention will be further described with reference to the following embodiments, and it should be apparent that the described embodiments are only a part of the embodiments of the present invention, and not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention. The starting materials used in the examples are commercially available and the procedures used are conventional in the art unless otherwise specified. The percentages (%) in the examples represent percentages by weight, unless otherwise indicated.
Some of the raw material sources in the examples are as follows:
the compound amino acid is purchased from Korea International trade of Guangzhou, Inc., and has a model number of
600, comprising the following components: betaine 26.87%, PCA-Na 9.75%, pyrrolidone carboxylic acid 3.78%, calcium lactate 5%, serine 1.12%, alanine 1.06%, glycine 1%, glutamic acid 0.43%, lysine HCl 0.34%, threonine 0.32%, arginine 0.29%, proline 0.04%, trehalose 25% and water balance.
The skin conditioner is purchased from Oryza chemical Co., Ltd, and has the model of SymCitive 1609, and comprises the following components: 70% of 1, 2-pentanediol and 30% of 4-tert-butylcyclohexanol.
The preservative consists of methylparaben and hexanediol, and the weight ratio of the methylparaben to the hexanediol is 2: 3.
Examples 1 to 3 provide essence for promoting eyelash growth, whose formula is shown in table 1. The preparation method of the essence comprises the steps of uniformly mixing all the components.
Comparative examples 1 to 3 provide essence solutions, the formula of which is shown in table 1, and the preparation method is the same as in examples 1 to 3.
TABLE 1
Test examples
1. Test population
Screening 20-45-year-old people without serious system diseases, immunodeficiency or autoimmune diseases, active allergic diseases, severe allergy history to cosmetics, hormone medicines and immunosuppressants which have not been used in the last month, and other subjects who are clinically tested.
2. Test method
120 qualified subjects were selected and randomized into 6 groups of 20 subjects with no significant difference between groups. The essence liquids of examples 1-3 and comparative examples 1-3 are respectively used for each test component, the test product is applied to the root of eyelashes of the eyes once every day after face cleaning in the morning and evening, the test period is 28 days, and the total usage amount is 15 mL. The length and number of eyelashes of each group of testees before and after the test are recorded, the average value is taken, the average value is recorded once before the test is started, and the average value is recorded once on the 7 th, 17 th and 28 th days of the test.
3. The test results are shown in tables 2-4.
TABLE 2 mean change in eyelash length (in mm compared to day 0)
| Sample (I) | Day 0 | Day 7 | Day 14 | Day 28 |
| Example 1 | 4.15 | +0.58 | +1.45 | +2.39 |
| Example 2 | 4.11 | +0.29 | +0.88 | +1.97 |
| Example 3 | 3.98 | +0.63 | +1.37 | +2.13 |
| Comparative example 1 | 4.35 | +0.15 | +0.28 | +0.40 |
| Comparative example 2 | 4.17 | +0.27 | +0.54 | +0.93 |
| Comparative example 3 | 4.06 | +0.43 | +1.23 | +1.36 |
TABLE 3 eyelash number Change (compare with day 0, Unit root)
| Sample (I) | Day 0 | Day 7 | Day 14 | Day 28 |
| Example 1 | 36 | +5 | +8 | +12 |
| Example 2 | 39 | +2 | +4 | +7 |
| Example 3 | 35 | +3 | +7 | +11 |
| Comparative example 1 | 38 | 0 | +1 | +3 |
| Comparative example 2 | 40 | +1 | +2 | +4 |
| Comparative example 3 | 35 | +3 | +4 | +6 |
TABLE 4 Subjects 28-day self-assessment
As can be seen from the tables 2 to 4, the eyelash growth conditions of the subjects who use the essences of the examples 1 to 3 are obviously better than those of the subjects who use the essences of the comparative examples 1 to 3, and the eyelash growth promoting effect of the composition is remarkably improved when the compound amino acid, the adenosine and the myristoyl pentapeptide-4 are used in a compounding manner. The essence of examples 1-3 significantly promotes eyelash growth of the subject after 7 days of use, with the best effect of example 1.
Finally, it should be noted that the above embodiments are only used for illustrating the technical solutions of the present invention and not for limiting the protection scope of the present invention, and although the present invention is described in detail with reference to the preferred embodiments, it should be understood by those skilled in the art that modifications or equivalent substitutions can be made on the technical solutions of the present invention without departing from the spirit and scope of the technical solutions of the present invention.
Claims (8)
1. The composition for promoting eyelash growth is characterized by comprising the following components in parts by weight: 0.05-0.3 part of sodium hyaluronate, 0.2-1.2 parts of sodium polyaspartate, 0.2-2 parts of compound amino acid, 0.005-0.1 part of pyridoxine HCl, 0.005-0.1 part of adenosine, 0.2-1 part of skin conditioner, 0.005-1 part of myristoyl pentapeptide-40.0001 and 0.005-0.2 part of menthol; the skin conditioning agent is a mixture of 1, 2-pentanediol and 4-tert-butylcyclohexanol.
2. The composition for promoting eyelash growth according to claim 1, wherein said composition for promoting eyelash growth comprises the following components in parts by weight: 0.1 part of sodium hyaluronate, 0.5 part of polyaspartic acid sodium, 1 part of compound amino acid, 0.02 part of pyridoxine HCl, 0.02 part of adenosine, 0.3 part of skin conditioner, 40.1 parts of myristoyl pentapeptide and 0.01 part of menthol.
3. A composition for promoting eyelash growth according to claim 1 or 2, wherein said complex amino acid comprises at least two of serine, alanine, glycine, glutamic acid, lysine HCl, threonine, arginine, proline.
4. A composition for promoting eyelash growth according to claim 1 or 2, wherein said skin conditioner comprises the following components in percentage by weight: 70% of 1, 2-pentanediol and 30% of 4-tert-butylcyclohexanol.
5. Use of a composition for promoting eyelash growth as set forth in any one of claims 1 to 4 in cosmetics.
6. A cosmetic comprising the composition for promoting eyelash growth according to any one of claims 1 to 4.
7. The cosmetic product according to claim 6, wherein said composition for promoting eyelash growth comprises the following components in percentage by weight: 0.05-0.3% of sodium hyaluronate, 0.2-1.2% of polyaspartic acid sodium, 0.2-2% of compound amino acid, 0.005-0.1% of pyridoxine HCl, 0.005-0.1% of adenosine, 0.2-1% of skin conditioner, 0.005-1% of myristoyl pentapeptide-40.0001 and 0.005-0.2% of menthol.
8. The cosmetic product according to claim 7, wherein said composition for promoting eyelash growth comprises the following components in percentage by weight: 0.1% of sodium hyaluronate, 0.5% of sodium polyaspartate, 1% of compound amino acid, 0.02% of pyridoxine HCl, 0.02% of adenosine, 0.3% of skin conditioner, 40.1% of myristoyl pentapeptide and 0.01% of menthol.
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| CN202011385769.1A CN112402295B (en) | 2020-12-01 | 2020-12-01 | Composition for promoting eyelash growth and application thereof |
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Citations (8)
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|---|---|---|---|---|
| JP2005225817A (en) * | 2004-02-13 | 2005-08-25 | Jiyugaoka Clinic | Hair-growing agent for eyelash |
| US20080269332A1 (en) * | 2007-04-26 | 2008-10-30 | La Canada Ventrures, Inc. | Eyelash enhancement composition and method of treatment |
| CN105232358A (en) * | 2015-10-29 | 2016-01-13 | 中山卡丝生物科技有限公司 | Compound for promoting eyelash growth and preparation method thereof |
| CN106214509A (en) * | 2016-08-24 | 2016-12-14 | 上海波林丝生物科技有限公司 | A kind of compositions promoting eyelashes to grow |
| CN109432400A (en) * | 2018-12-27 | 2019-03-08 | 深圳市福美富基因科技有限公司 | A kind of trichogenous composition and its application |
| WO2019166521A1 (en) * | 2018-02-28 | 2019-09-06 | Symrise Ag | Dermatological product |
| CN111084726A (en) * | 2020-01-08 | 2020-05-01 | 北京幸福益生再生医学科技有限公司 | Hair loss prevention and hair growth composition and preparation method thereof |
| CN111150693A (en) * | 2019-12-18 | 2020-05-15 | 广州市妆妍生物技术有限公司 | Eyelash nourishing liquid and preparation method thereof |
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2020
- 2020-12-01 CN CN202011385769.1A patent/CN112402295B/en active Active
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| JP2005225817A (en) * | 2004-02-13 | 2005-08-25 | Jiyugaoka Clinic | Hair-growing agent for eyelash |
| US20080269332A1 (en) * | 2007-04-26 | 2008-10-30 | La Canada Ventrures, Inc. | Eyelash enhancement composition and method of treatment |
| CN105232358A (en) * | 2015-10-29 | 2016-01-13 | 中山卡丝生物科技有限公司 | Compound for promoting eyelash growth and preparation method thereof |
| CN106214509A (en) * | 2016-08-24 | 2016-12-14 | 上海波林丝生物科技有限公司 | A kind of compositions promoting eyelashes to grow |
| WO2019166521A1 (en) * | 2018-02-28 | 2019-09-06 | Symrise Ag | Dermatological product |
| CN109432400A (en) * | 2018-12-27 | 2019-03-08 | 深圳市福美富基因科技有限公司 | A kind of trichogenous composition and its application |
| CN111150693A (en) * | 2019-12-18 | 2020-05-15 | 广州市妆妍生物技术有限公司 | Eyelash nourishing liquid and preparation method thereof |
| CN111084726A (en) * | 2020-01-08 | 2020-05-01 | 北京幸福益生再生医学科技有限公司 | Hair loss prevention and hair growth composition and preparation method thereof |
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| Title |
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| 渡会治仁: "《无师自通基本化妆技巧》", 30 June 2015, 河北科学技术出版社 * |
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