CN105232358A - Compound for promoting eyelash growth and preparation method thereof - Google Patents

Abstract

The invention provides a complex for promoting eyelash growth, which consists of the following components in terms of mass percentage: 0.09%-0.15% of myristoyl pentapeptide-17, 0.09%-0.15% of myristoyl hexapeptide- 16. 0.025%-0.045% biotin tripeptide-1, 1%-3% vitamin E, 0.05%-0.1% olive oil, 0.2%-0.4% sodium hyaluronate, 0.4%-0.5% panthenol, 4%-6% glycerin, 0.3%-0.5% 1,2-hexanediol and an appropriate amount of arginine, and the balance is pure water so that the total proportion is 100%. Correspondingly, the present invention also A method for the preparation of the complex is provided. The eyelash growth-promoting compound provided by the invention can activate eyelash follicle keratin gene, stimulate the production of keratin-5, promote the absorption of nutrients by eyelash follicles, and have the functions of increasing the number of eyelashes, improving the luster, thickness and length of eyelashes, etc. significant effect.

Description

A compound for promoting growth of eyelashes and preparation method thereof

technical field

The invention relates to a compound for promoting the growth of eyelashes and a preparation method thereof. The compound is mainly used for promoting the growth of eyelashes, and has the effect of making the eyelashes thicker and longer.

Background technique

Consumers are continually seeking to improve the appearance of their lashes, including thinning or thinning lashes, lashes that are not as long as desired, or that lack a healthy, volumized appearance, and there remains a need for eye products that correct such deficiencies. Eyelashes have a follicular structure, which is located in the skin, and a hair shaft or fiber, which is visible above the skin. The hair follicle is the living part of the eyelash and contains various cell types, such as keratinocytes and melanocytes, whose main role is to generate the hair shaft and regulate eyelash growth. Eyelash follicles undergo a repetitive sequence of growth and rest, known as the "anagen cycle" or "eyelash growth cycle," and are distinct from the anagen cycle of scalp hair follicles.

Because the hair follicles of the eyelashes are at the end of the blood circulation, many physiological and pathological reasons can cause insufficient nutritional supply of the hair follicle tissue cells, resulting in the scarcity of eyelashes in most people. Having thick and slender eyelashes is the dream of many beauty-loving women, but Pimoprostamine, which is sold on the market, is a prescription drug for treating glaucoma. Although it can promote the growth of eyelashes and is sought after by consumers, it will cause eye damage. Side effects such as redness and itching, excessive use can also cause optic nerve damage, and the promoted eyelash growth is not long-lasting. Therefore, cosmetics that promote eyelash growth and are safe need to be studied. They should not contain undesired ingredients (such as apigenin), and use a smaller amount of active ingredients to prepare cosmetics such as eyelash growth liquid, eyeliner, and eyelash repair liquid.

Contents of the invention

In view of the above technical problems, the purpose of the present invention is to provide a compound for promoting eyelash growth, which is used to improve the overall appearance and health of eyelashes, and accordingly provides a preparation method of the compound.

In order to realize the technical purpose of the present invention, the present invention adopts the following technical solutions.

A complex for promoting eyelash growth, which consists of the following components in terms of mass percentage: 0.09%-0.15% myristoyl pentapeptide-17, 0.09%-0.15% myristoyl hexapeptide-16, 0.025% -0.045% Biotin Tripeptide-1, 1%-3% Vitamin E, 0.05%-0.1% Olive Oil, 0.2%-0.4% Sodium Hyaluronate, 0.4%-0.5% Panthenol, 4 %-6% glycerin, 0.3%-0.5% 1,2-hexanediol and an appropriate amount of arginine, and the balance is purified water.

Correspondingly, the present invention also provides a preparation method of the complex, which adopts the following steps:

(a) Add 70%-80% pure water according to the proportion, heat, add 1,2-hexanediol, stir to dissolve, and divide into four equal parts, namely A phase, B phase, C phase and D phase Mutually;

(b) Keep the temperature of phase A at 50°C-80°C, stir and add sodium hyaluronate, continue stirring to dissolve and mix evenly, and use it as phase I;

(c) Add myristoyl pentapeptide-17, myristoyl hexapeptide-16, and biotin tripeptide-1 into phase B, stir to dissolve and mix evenly, then filter with a filter membrane, and the obtained filtrate is phase II;

(d) Keep the temperature of phase C at 50°C-80°C, add vitamin E, stir, mix well, then add glycerin and olive oil, and mix thoroughly as phase III;

(e) Add panthenol to phase D, stir and mix evenly, as phase IV;

(f) Add phase II, phase III and phase IV to phase I under stirring, rinse the containers of phase II, phase III and phase IV with the remaining proportion of pure water, and add the rinse solution to the In Phase I, stir to mix evenly;

(g) adjust the pH value of the mixed solution to 6.0-7.0 with arginine, and the obtained complex is the product of the present invention.

Preferably, the heating temperature in the step (a) is 80°C.

Preferably, the filter membrane in the step (c) is a 0.45 μm filter membrane.

Preferably, the concentration of arginine in the step (g) is 15wt%.

The beneficial effects of the present invention are: according to the growth mechanism of eyelashes, the present invention activates the eyelash follicle keratin gene by selecting myristoyl pentapeptide-17 and myristoyl hexapeptide-16, thereby promoting the growth of eyelashes and increasing the thickness of eyelash roots. Biotin tripeptide-1 is used to fix the newly grown eyelashes, and the effective combination of olive oil and natural vitamin E provides the most fundamental nutrients for eyelash growth, deeply nourishes eyelashes, and prevents eyelashes from falling due to dryness. Panthenol acts as A derivative of vitamin B5, it can penetrate into the eyelashes after being added and quickly be reduced to vitamins under the action of enzymes, nourishing the eyelashes and making them shiny and moist. The present invention activates the eyelash follicle keratin gene through various biological polypeptides and their complexes with nutrients, stimulates the production of keratin-5, promotes the absorption of nutrients by eyelash follicles, and can synergistically increase the number of eyelashes, improve eyelash luster, thickness and length.

detailed description

In order to better understand the present invention, the invention will be described in detail below in conjunction with the examples. If there is no special description, the following examples are all in mass percentage.

Example 1:

(a) Add 70% pure water according to the ratio, heat to 80°C, add 0.3% 1,2-hexanediol, stir to dissolve, and divide into four equal parts, namely A phase, B phase, C phase phase and D phase;

(b) Keep the temperature of phase A at 50°C, stir and add 0.2% sodium hyaluronate, continue stirring to dissolve and mix evenly, and use it as phase I;

(c) Add 0.09% myristoyl pentapeptide-17, 0.15% myristoyl hexapeptide-16, and 0.025% biotin tripeptide-1 into phase B, stir to dissolve and mix evenly, and then use 0.45 μm Membrane filtration, the obtained filtrate is phase II;

(d) Keep the temperature of phase C at 60°C, add 2% vitamin E, stir, mix evenly, then add 4% glycerin and 0.05% olive oil, mix thoroughly as phase III;

(e) Add 0.5% panthenol to phase D, stir and mix evenly, as phase IV;

(f) Add phase II, phase III and phase IV to phase I under stirring, rinse the containers of phase II, phase III and phase IV with the remaining proportion of pure water, and add the rinse solution to the In Phase I, stir to mix evenly;

(g) Use 15% arginine to adjust the pH value of the mixed solution to 6.0-7.0, and the obtained complex is the product of the present invention.

Example 2:

(a) Add 80% pure water according to the ratio, heat to 80°C, add 0.5% 1,2-hexanediol, stir to dissolve, and divide into four equal parts, namely A phase, B phase, C phase phase and D phase;

(b) Keep the temperature of phase A at 80°C, add 0.4% sodium hyaluronate with stirring, and continue stirring to dissolve and mix evenly, as phase I;

(c) Add 0.15% myristoyl pentapeptide-17, 0.09% myristoyl hexapeptide-16, and 0.045% biotin tripeptide-1 into phase B, stir to dissolve and mix evenly, and then use 0.45 μm Membrane filtration, the obtained filtrate is phase II;

(d) Keep the temperature of phase C at 80°C, add 3% vitamin E, stir, mix evenly, then add 6% glycerin and 0.1% olive oil, mix thoroughly as phase III;

(e) Add 0.4% panthenol to phase D, stir and mix evenly, as phase IV;

(f) Add phase II, phase III and phase IV to phase I under stirring, rinse the containers of phase II, phase III and phase IV with the remaining proportion of pure water, and add the rinse solution to the In Phase I, stir to mix evenly;

(g) Use 15% arginine to adjust the pH value of the mixed solution to 6.0-7.0, and the obtained complex is the product of the present invention.

Example 3:

(a) Add 80% pure water according to the ratio, heat to 80°C, add 0.4% 1,2-hexanediol, stir to dissolve, and divide into four equal parts, namely A phase, B phase, C phase phase and D phase;

(b) Keep the temperature of phase A at 70°C, add 0.4% sodium hyaluronate with stirring, and continue stirring to dissolve and mix evenly, as phase I;

(c) Add 0.12% myristoyl pentapeptide-17, 0.12% myristoyl hexapeptide-16, and 0.035% biotin tripeptide-1 into phase B, stir to dissolve and mix evenly, and then use 0.45 μm Membrane filtration, the obtained filtrate is phase II;

(d) Keep the temperature of phase C at 50°C, add 1% vitamin E, stir, mix well, then add 5% glycerin and 0.1% olive oil, and mix well as phase III;

(e) Add 0.5% panthenol to phase D, stir and mix evenly, as phase IV;

(f) Add phase II, phase III and phase IV to phase I under stirring, rinse the containers of phase II, phase III and phase IV with the remaining proportion of pure water, and add the rinse solution to the In Phase I, stir to mix evenly;

(g) Use 15% arginine to adjust the pH value of the mixed solution to 6.0-7.0, and the obtained complex is the product of the present invention.

Comparative example 4 (without biotin tripeptide-1):

(a) Add 70% pure water according to the ratio, heat to 80°C, add 0.3% 1,2-hexanediol, stir to dissolve, and divide into four equal parts, namely A phase, B phase, C phase phase and D phase;

(b) Keep the temperature of phase A at 50°C, stir and add 0.2% sodium hyaluronate, continue stirring to dissolve and mix evenly, and use it as phase I;

(c) Add 0.09% myristoyl pentapeptide-17 and 0.15% myristoyl hexapeptide-16 into phase B, stir to dissolve and mix evenly, then filter with a 0.45 μm filter membrane, and the obtained filtrate is phase II;

(d) Keep the temperature of phase C at 60°C, add 2% vitamin E, stir, mix evenly, then add 4% glycerin and 0.05% olive oil, mix thoroughly as phase III;

(e) Add 0.5% panthenol to phase D, stir and mix evenly, as phase IV;

(f) Add phase II, phase III and phase IV to phase I under stirring, rinse the containers of phase II, phase III and phase IV with the remaining proportion of pure water, and add the rinse solution to the In Phase I, stir to mix evenly;

(g) Use 15% arginine to adjust the pH value of the mixed solution to 6.0-7.0, and the obtained compound is the product of Comparative Example 1.

Comparative example 5 (without vitamin E and myristoyl pentapeptide-17):

(a) Add 80% pure water according to the ratio, heat to 80°C, add 0.5% 1,2-hexanediol, stir to dissolve, and divide into four equal parts, namely A phase, B phase, C phase phase and D phase;

(b) Keep the temperature of phase A at 80°C, add 0.4% sodium hyaluronate with stirring, and continue stirring to dissolve and mix evenly, as phase I;

(c) Add 0.09% myristoyl hexapeptide-16 and 0.045% biotin tripeptide-1 into phase B, stir to dissolve and mix evenly, then filter with a 0.45 μm filter membrane, and the obtained filtrate is phase II;

(d) Keep the temperature of phase C at 80°C, stir, mix evenly, add 6% glycerin and 0.1% olive oil, and mix thoroughly as phase III;

(e) Add 0.4% panthenol to phase D, stir and mix evenly, as phase IV;

(f) Add phase II, phase III and phase IV to phase I under stirring, rinse the containers of phase II, phase III and phase IV with the remaining proportion of pure water, and add the rinse solution to the In Phase I, stir to mix evenly;

(g) Use 15% arginine to adjust the pH value of the mixed solution to 6.0-7.0, and the obtained compound is the product of Comparative Example 2.

Comparative example 6 (without myristoyl hexapeptide-16):

(a) Add 80% pure water according to the ratio, heat to 80°C, add 0.4% 1,2-hexanediol, stir to dissolve, and divide into four equal parts, namely A phase, B phase, C phase phase and D phase;

(b) Keep the temperature of phase A at 70°C, add 0.4% sodium hyaluronate with stirring, and continue stirring to dissolve and mix evenly, as phase I;

(c) Add 0.12% myristoyl pentapeptide-17 and 0.035% biotin tripeptide-1 into phase B, stir to dissolve and mix evenly, then filter with a 0.45 μm filter membrane, and the obtained filtrate is phase II;

(d) Keep the temperature of phase C at 50°C, add 1% vitamin E, stir, mix well, then add 5% glycerin and 0.1% olive oil, and mix well as phase III;

(e) Add 0.5% panthenol to phase D, stir and mix evenly, as phase IV;

(f) Add phase II, phase III and phase IV to phase I under stirring, rinse the containers of phase II, phase III and phase IV with the remaining proportion of pure water, and add the rinse solution to the In Phase I, stir to mix evenly;

(g) Use 15% arginine to adjust the pH value of the mixed solution to 6.0-7.0, and the obtained compound is the product of Comparative Example 3.

The products of Examples 1-3 and Comparative Examples 4-6 were divided into 6 groups of experiments, and 20 volunteers were selected for each group, aged between 20 and 30 years old, with the problem of scarcity of eyelashes. Apply the corresponding product twice for 56 days, and evaluate the length, thickness, quantity, and other aspects of eyelashes before and after 28 days and 56 days of use.

The effects of Examples 1-3 and Comparative Examples 4-6 before and after 28 days and 56 days of use are shown in Table 1 and Table 2, respectively.

Table 1 embodiment and comparative example use eyelash growth effect after 28 days

Test items Example 1 Example 2 Example 3 Comparative example 4 Comparative example 5 Comparative example 6 eyelash length 18.7% increase 18.2% increase 18.1% increase 16.7% increase 17.7% increase 17.1% increase Thickness of eyelashes 5.1% increase 5.0% increase 4.9% increase 2.4% increase 2.9% increase 2.6% increase Number of eyelashes 16.0% increase 15.7% increase 15.8% increase 7.6% increase 7.2% increase 7.9% increase

Table 2 embodiment and comparative example use eyelash growth effect after 56 days

Test items Example 1 Example 2 Example 3 Comparative example 4 Comparative example 5 Comparative example 6 eyelash length 22.3% increase 21.7% increase 20.9% increase 18.7% increase 19.2% increase 19.7% increase Thickness of eyelashes 6.5% increase 6.2% increase 6.1% increase 3.9% increase 3.7% increase 4.1% increase Number of eyelashes 36.4% increase 33.9% increase 32.7% increase 8.9% increase 8.2% increase 8.7% increase

According to the data in the above table, it can be clearly seen that the eyelash growth-promoting compound provided by the present invention can activate the eyelash follicle keratin gene, stimulate the production of keratin-5, and promote the absorption of nutrients by the eyelash follicles. Visible results in lash shine, thickness and length.

The basic principles, main features and advantages of the present invention have been shown and described above. Those skilled in the industry should understand that the above-mentioned embodiments do not limit the present invention in any form, and all technical solutions obtained by means of equivalent replacement or equivalent transformation fall within the protection scope of the present invention.

Claims (5)

1. the complex promoting eyelashes to grow, it is characterized in that, by percentage to the quality, composed of the following components: the biotin tripeptides-1 of the myristoyl pentapeptide-17 of 0.09%-0.15%, myristoyl six peptide-16 of 0.09%-0.15%, 0.025%-0.045%, the vitamin E of 1%-3%, the olive oil of 0.05%-0.1%, the hyaluronate sodium of 0.2%-0.4%, the pantothenylol of 0.4%-0.5%, the glycerol of 4%-6%, 1 of 0.3%-0.5%, 2-hexanediol, surplus is pure water.

2. the preparation method of a kind of complex promoting eyelashes to grow according to claim 1, is characterized in that, adopts following steps:

A () adds the pure water of 70%-80% by proportioning, heating, adds 1,2-hexanediol, stirs after making it dissolve, is divided into four parts, is respectively A phase, B phase, C phase and D phase;

B () keeps A phase temperature to be 50 DEG C-80 DEG C, stir and add hyaluronate sodium, continues stirring and makes it dissolve mix homogeneously, as I phase;

C myristoyl pentapeptide-17, myristoyl six peptide-16, biotin tripeptides-1 join in B phase by (), after stirring and dissolving mix homogeneously, with membrane filtration, gained filtrate is II phase;

D () keeps C phase temperature to be 50 DEG C-80 DEG C, add vitamin E, stirs, adds glycerol and olive oil again after mix homogeneously, as III phase after fully mixing;

E pantothenylol joins in D phase by (), be uniformly mixed, as IV phase;

F II phase, III phase and IV are added in I phase by () under stirring, with the pure water of residue proportional quantity respectively rinse II phase, III phase and IV container, and the rinse liquid obtained to be joined in I phase, is uniformly mixed;

G () regulates mixed solution pH value to be 6.0-7.0 with arginine, gained complex is product of the present invention.

3. method according to claim 2, is characterized in that: in described step (a), heating-up temperature is 80 DEG C.

4. method according to claim 2, is characterized in that: in described step (c), filter membrane is the filter membrane of 0.45 μm.

5. method according to claim 2, is characterized in that: in described step (g), arginic concentration is 15wt%.