CN104814884B

CN104814884B - A kind of pre-Anti-hair loss and trichogenous shampoo and preparation method thereof

Info

Publication number: CN104814884B
Application number: CN201510190767.XA
Authority: CN
Inventors: 李珍爱; 苏移山; 赵文刚; 朱希强; 张林军
Original assignee: SHANDONG FREDA BIOTECHNOLOGY CO Ltd
Current assignee: SHANDONG FREDA BIOTECHNOLOGY CO Ltd
Priority date: 2015-04-21
Filing date: 2015-04-21
Publication date: 2017-09-01
Anticipated expiration: 2035-04-21
Also published as: CN104814884A

Abstract

The invention provides a kind of pre-Anti-hair loss and trichogenous shampoo and preparation method thereof, belong to household chemicals technical field.Main composition in the shampoo is super-high molecular weight gamma polyglutamic acid, in addition to shampoo conventional ingredient, also include other nutritional ingredients, including function factors such as amino acid, vitamin, collagens, only effectively pre-Anti-hair loss and do not promote hair growth compared to conventional therapy alopecia agent, and have no side effect, with good hair care moisture-keeping function, prevent hair from drying up short-tempered, make hair more smooth beautiful glossy.

Description

A kind of pre-Anti-hair loss and trichogenous shampoo and preparation method thereof

Technical field

The invention belongs to household chemicals technical field, and in particular to a kind of pre-Anti-hair loss and trichogenous hair washing Water and preparation method thereof.

Background technology

Baldness is the regular incidence in dept. of dermatology, the health index promulgated according to national departments concerned, in the adult of China In group, the alopecia incidence of disease is up to 30%.With the exacerbation of operating pressure, the quickening of rhythm of life and is scalded at ambient influnence and hair dyeing Use and popularization of the molded products such as hair etc., hair loss patient progressively occurs in that the sign of rejuvenation, and with annual 17.5% speed Degree is incremented by.Clinical medicine carries out many explanations to alopecia reason, but it is atrophy and degeneration because hair follicle at all, it is impossible to It is set to absorb surrounding hair nutrient, hair not regrowth naturally.Current traditional Chinese and western medicine works out multi-medicament from this angle Carry out the hair follicle restoration ecosystem of inducing involution, and extend growth period.Being most commonly used for the medicine of hair growth at present includes rice Promise ground you and Finasteride etc., pass through long-term clinical practice, although preferably, but side effect is more, is applicable people for these effect of drugs Group lacks, and must largely use for a long time, and women causes the excessive risk of embryo's congenital abnormality using Finasteride, and male uses meeting There is sexual hypoesthesia, the side effect such as impotence, for the effect that maintains pre-Anti-hair loss the pressure brought of taking medicine all the life cause its It is severely limited in practical clinical.

γ-PGA are a kind of water-soluble polyamino acids of high viscosity fermented by natural microorganisms, and its structure is by D- paddy ammonia By the same polyamide generated after alpha-amido and β-carboxyl formation peptide bond between acid and Pidolidone monomer, the degree of polymerization about exists Between 1000~15000.It is commercial it is general prepared using the bacillus subtilis screened from natto and clear bent sauce, with good Good water solubility, superpower adsorptivity is thoroughly biodegradable, nontoxic to wait unique physics, chemistry and biology characteristic.

The content of the invention

The present invention adds γ-PGA that are natural, nuisanceless, having no side effect in shampoo, and can also arrange in pairs or groups needed by human body Nutritional ingredient and trace element, and surfactant, stabilizer, essence prepare a kind of pre-Anti-hair loss and trichogenous Shampoo, can not only prevent and treat alopecia, and because itself is complicated, viscosity is higher, advantageously forms close network, So as to pin the small molecule nutritional ingredient in shampoo such as amino acid, trace element etc., and then play hair care moisturizing well Effect, prevent hair from drying up short-tempered, while skin of head can be played a part of moisten nursing, make hair more smooth beautiful and Glossy and elasticity.

The technical scheme is that：

One kind prevention and treatment alopecia shampoo, it is characterized in that, its active ingredient is super-high molecular weight gamma-polyglutamic acid； The molecular weight of the super-high molecular weight gamma-polyglutamic acid is 100-300 ten thousand.

Further, in the prevention and treatment alopecia shampoo, super-high molecular weight gamma-polyglutamic acid concentration is 0.5%- 3%.

Further, following components is also included in the shampoo：

Surfactant 10%-15%, biological foaming agent 10%, NMF 0.32-0.75%, thickener 0.8%, stably Agent 0.5%-1%, essence 0.1%-0.5%, nertralizer 0.05-0.15%.

Further,

The surfactant is in ammonium lauryl sulfate, 12 fat ammonium sulfate, dodecyl polyoxy ether ammonium sulfate One or two；

The biological foaming agent is one or both of coconut monoethanolamide and Cocoamidopropyl betaine；

The NMF is one or both of panthenol, E-20；

The thickener is polyquaternium Q-10, carboxyethyl cellulose, acrylic acid, the one or more of acrylate；

The stabilizer is one or both of EDTA, EDETATE SODIUM；

The nertralizer is citric acid, sodium citrate, keeps shampoo pH between 6.0-6.5.

Further, silicones, fatty alcohol and macadamia nut oil are also included in the shampoo.

Further, the silicones is dimethicone.

Further, nutritional ingredient is also included in the shampoo；

The nutritional ingredient is protide, vitamin, ceramide, trace element.

Further, the nutritional ingredient is protide 0.3%-1%, vitamin 0.1%-0.8%, ceramide 0.02%-0.05%, micro- 0.01%-0.08%.

Further,

The protide is collagen and amino acid；

The vitamin is vitamin A, vitamin B5, vitamin C, vitamin E；

The trace element is copper, iron, zinc and calcium salt.

The beneficial effects of the invention are as follows：

(1) present invention uses the gamma-polyglutamic acid (poly- γ-glutamic of super high molecular weight (700,000~3,000,000) Acid, abbreviation PGA) it can effectively suppress the activity of 5α-reductase, so that hair growth and promotion hair growth.5α-reductase has Two kinds of isodynamic enzymes, can change into testosterone dihydrotestosterone (DHT), and DHT is a kind of active male sex hormone, itself and specific receptor knot Conjunction can produce the protein for causing alopecia, so as to cause alopecia.Therefore can fundamentally have by suppressing the activity of 5α-reductase The prevention and treatment alopecia of effect.It provides the pre-Anti-hair loss and trichogenous effect equal to or higher than conventional therapy agent Really, its usage amount will be much smaller than conventional therapy agent；

(2) side effect without the conventional therapy agent；

(3) routine use, effectively pre-Anti-hair loss and can not only promote hair growth, moreover it is possible to improve hair quality, moisturizing of taking care of hair, Make hair more smooth beautiful glossy.

Embodiment

For a better understanding of the present invention, with reference to the embodiment content that the present invention is furture elucidated, but the present invention Content is not limited solely to the following examples, and embodiment is not construed as limiting the scope of the present invention.

Embodiment 1

Formula：0.5% super-high molecular weight gamma-PGA, dodecyl polyoxy ether ammonium sulfate 6%, 12 fat ammonium sulfate 4%, Cocoamidopropyl betaine 10%, dimethicone 0.5%, panthenol 0.75%, EDTA 0.5%, polyquaternium Q-10 0.5%, acrylic acid 0.3%, essence 0.1%, balance deionized water.

Preparation technology：In the super-high molecular weight gamma-PGA aqueous solution containing 0.5%, less than 50 DEG C under the conditions of sequentially add Dodecyl polyoxy ether ammonium sulfate 6%, 12 fat ammonium sulfate 4%, Cocoamidopropyl betaine 10%, dimethicone 0.5%, panthenol 0.75%, EDTA 0.5%, polyquaternium Q-10 0.5%, acrylic acid 0.3%, essence 0.1%, stirring is equal Add deionized water to 100% after even, pH is adjusted to 6.0-6.5 using citric acid and sodium citrate, prepare γ-PGA hair washing jellyfishes Liquid, shampoo as of the present invention.

Embodiment 2：

Formula：

1% super-high molecular weight gamma-PGA, dodecyl polyoxy ether ammonium sulfate 9%, ammonium lauryl sulfate 6%, coconut Acid amides 10%, dimethicone 0.8%, E-20 0.75%, EDETATE SODIUM 0.5%, polyquaternium Q-10 0.4%, ethoxy Cellulose 0.4%, essence 0.5%, collagen 0.5%, amino acid 0.5%, vitamin A 0.2%, vitamin B5 0.2%, Vitamin C 0.3%, vitamin E 0.1%, ceramide 0.05%, trace copper, iron, zinc and calcium salt each 0.02% are remaining Measure deionized water.

Preparation technology：

In the super-high molecular weight gamma-PGA aqueous solution containing 1%, less than 50 DEG C under the conditions of sequentially add dodecyl gather Oxygen ether ammonium sulfate 9%, ammonium lauryl sulfate 6%, coconut monoethanolamide 10%, dimethicone 0.8%, E-20 0.75%, EDETATE SODIUM 0.5%, polyquaternium Q-10 0.4%, hydroxyethyl cellulose 0.4%, essence 0.5%, after stirring plus go from Sub- water adjusts pH to 6.0-6.5, prepares γ-PGA shampoo mother liquors to 100% using citric acid and sodium citrate.

Function factor collagen 0.5%, amino acid are sequentially added under the conditions of being less than 50 DEG C in shampoo mother liquor 0.5%, vitamin A 0.2%, vitamin B5 0.2%, vitamin C 0.3%, vitamin E 0.1%, ceramide 0.05%, trace copper, iron, zinc and calcium salt each 0.02% produce shampoo of the present invention.

Add after function factor, the enhancing of its Nutritional Nursing Care effect.Wherein collagen can make the cutin light of composition hair Sliding protein molecule is combined closely, and keeps hair internal structure tough；Amino acid is the basis of constitutive protein matter, can be supplemented Primary amino acid needed for cortical layer；Vitamin C can promote the synthesis of collagen, make damaged hair more smooth beautiful；Dimension life Plain B5 can promote the regeneration of fibroblast, help damaged hair tissue repair；Amino acid is fibrinous important composition portion Point, it is nutritional ingredient necessary to natural on-off cycles of hair growth, the primary amino acid needed for cortical layer can be supplemented, makes damaged hair recover flexible Property and elasticity, and promote cytothesis；Ceramide is a kind of efficient moisture-retention factor, acts on hair surface, forms protective layer, Reach moistening effect；Trace element is the basis of hair, hair must absorb enough mineral matter and trace element as copper, Iron, zinc, calcium etc. prevent and treat coming off for hair.

Embodiment 3

In order to verify that shampoo of the present invention prevents and treats the effect of alopecia, 30 ages of our company are have chosen between 25-60 Sui Volunteer, including 20 with baldness volunteers and the rare alopecia trend of 10 hair amounts volunteer there is provided this - the PGA containing super-high molecular weight gamma of invention prevention and treatment alopecia shampoo, the shampoo of specifically used embodiment 2, when using Between for 2-3 months, average every 2 weeks to the number of hairs of volunteer, hair thickness, hair quality progress observation statistics.

Result of the test：

(1) volunteer's number of hairs showed increased that alopecia is inclined to, thickness increase, and daily alopecia quantity reduce；

(2) 20 volunteers with baldness increase in hair loss area hair follicle, and alopecia area has more than 50% Hair grow again, therapeutic effect significantly, while there is not side effect；

(3) 30 volunteer's hair tip bifurcations are disappeared, and withered hair tail is moistened, and the crude phenomenon of hair significantly changes It is kind；

(4) on sense organ, the hair quality of volunteer becomes smooth not short-tempered, and hair is flexible, agile gloss, and patient satisfaction increases Plus.

Hair growth effect of the present invention significantly, has broken the conventional method of conventional therapy agent, using natural biological poly Amino acid come prevent and treat alopecia and promote hair growth, reduce curative compliance of the patient to medicine, baldness start occur When can prevent and treat, it is cheap, reduce patient's treatment burden, the pair work occurred during use without such as conventional therapeutic agent With applicable crowd is wide, while the big problem of hair 5 can also be solved, reduces hair tip bifurcated, moistens the hair tail that dries up, smooths crude hair Silk, healthy hair is recaptured tough, agile gloss, it is beautiful flexible.

Claims

1. one kind prevention and treatment alopecia shampoo, it is characterized in that, its active ingredient is super-high molecular weight gamma-polyglutamic acid；

The molecular weight of the super-high molecular weight gamma-polyglutamic acid is 100-300 ten thousand；

The shampoo is made up of following percentage raw material：1% super-high molecular weight gamma-polyglutamic acid, dodecyl polyoxyethylene Ether ammonium sulfate 9%, ammonium lauryl sulfate 6%, coconut monoethanolamide 10%, dimethicone 0.8%, E-20 0.75%, EDETATE SODIUM 0.5%, Polyquaternium-10 0.4%, hydroxyethyl cellulose 0.4%, essence 0.5%, collagen 0.5%, amino acid 0.5%, dimension life Plain A 0.2%, vitamin B5 0.2%, vitamin C 0.3%, vitamin E 0.1%, ceramide 0.05%, trace copper, iron, Zinc and calcium salt each 0.02%, balance deionized water.