CN110123659A - A kind of Anti-hair loss composition and its in the application for preparing Anti-hair loss and washing in shield product - Google Patents
A kind of Anti-hair loss composition and its in the application for preparing Anti-hair loss and washing in shield product Download PDFInfo
- Publication number
- CN110123659A CN110123659A CN201910457539.2A CN201910457539A CN110123659A CN 110123659 A CN110123659 A CN 110123659A CN 201910457539 A CN201910457539 A CN 201910457539A CN 110123659 A CN110123659 A CN 110123659A
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- hair
- hair loss
- parts
- sodium
- inosine
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- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
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- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
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Abstract
The application protected in product is washed the invention discloses a kind of Anti-hair loss composition and its preparing Anti-hair loss.Anti-hair loss composition of the invention, including inosine, lupin protein hydrolysate, caffeine；The inosine, lupin protein hydrolysate, the mass ratio between caffeine three are as follows: 1:1-20:1-5.Inosine, lupin protein hydrolysate, caffeine three are used cooperatively by the present invention, with significant alopecia-stopping effect, simultaneously, this combination also has the function of promoting hair hair tonic, principle is the hair follicle cell stimulated on scalp, the effect of making the hair follicle cell into dormant period regrow, increase the hair follicle quantity in growth period, and then play hair tonic.
Description
Technical field
The invention discloses a kind of Anti-hair loss compositions, belong to scalp care technical field, and in particular to a kind of Anti-hair loss
Composition and its application.
Background technique
Survey data shows that the alopecia crowd in China is up to 1.6 hundred million.In male, every 4 people just has one, and there are alopecias
Problem, and with environmental pollution exacerbation, the effect for the extraneous factors such as diet is irregular, operating pressure is big, alopecia crowd's is low
Ageization is increasingly apparent, and the health of masses, beauty consciousness are increasingly strong, therefore alopecia problem more and more attracts people's attention.
Alopecia can be divided into normal alopecia and pathologic alopecia by the difference of the origin cause of formation.Normal alopecia refers in catagen or stops
The only trichomadesis of phase, the hair that normal person falls off daily are that 70-100 root belongs to caused by being the metabolism of scalp hair follicles cell
The metabolism of human normal；And pathologic alopecia refers to that normal hair follicle cell occurs degenerating or causes hair into stand-down
Subalimentation and caused by fall off.Pathologic alopecia frequently can lead to the generation of phenomena such as bald, alopecia areata.
For being increasing for pathologic alopecia crowd, occur the anti-hair loss products of a great variety in the market.These are produced
Product are generally may be two classes, and a kind of product is based on Chinese medicine medical knowledge opinion, using compound herb extract, not according to formula material
Together, corresponding to generate nourishing or oil-control and other effects, to achieve the purpose that prevent hair loss, but divide the case where feedback after consumer's use
Analysis, most product effects are not very obvious；Another kind of product is the hair care product for being added to Western medicine, it is main to the west of
That non-, minoxidil etc. is used as active constituent, and such product has apparent phalacrosis prevention and hair generation effect using initial stage, but makes for a long time
With apparent side effect (sex dysfunction, hypopiesia etc.) is had, as a result lose more than gain.
It is related studies have shown that alopecia mainly causes the battalion of hair due to the degeneration atrophy of the hair follicle cell in scalp
It supports insufficient and leads to alopecia, therefore effectively to solve the problems, such as alopecia, be crucial for the enough nutrition that provides of hair follicle cell；
Simultaneously cooperate the hair follicle growth factor appropriate, alopecia not only can be effectively prevented, but promote into dormant period hair follicle again
Growth, and new hair is grown, to thoroughly solve the problems, such as alopecia.And currently, in existing technology or product, or pass through control
Oil inhibits the factor of hair follicle eubolism to eliminate to delay falling off for hair, or increases hair follicle blood flow (" promoting blood circulation ") and promote
Nutrition is provided into for hair follicle, no matter it is any, it can not fundamentally solve the problems, such as alopecia and hair regeneration.
Summary of the invention
It can only be used to delay falling off for hair to solve existing anti-hair loss products, and can not fundamentally solve alopecia
Defect, to provide a kind of Anti-hair loss composition and application, the composition provide nutrition for the hair follicle cell in the phase of falling off, mention
The vigor of high hair follicle cell, delays the atrophy of papilla, to prevent falling off for hair, this composition of other hand also passes through pair
The stand-down hair follicle cell that hair has fallen off is stimulated, and the function of hair follicle is activated, and hair follicle cell is made to grow new hair again,
And then the effect of playing hair tonic, to fundamentally solve the problems, such as alopecia and hair regeneration.
A kind of Anti-hair loss composition, including inosine, lupin protein hydrolysate, caffeine.
Preferably, the Anti-hair loss composition, inosine, lupin protein hydrolysate, caffeine three mass ratio are as follows:
1:1-20:1-5.
Preferably, the Anti-hair loss composition, inosine, lupin protein hydrolysate, caffeine mass ratio be 1:2:
1,1:3:1 or 1:3:2.
Preferably, the Anti-hair loss composition, further includes: L-arginine, ornithine, small molecule chitosan, polygonum cuspidate
Extract；The L-arginine, ornithine, small molecule chitosan, the mass ratio between Gentrin Knotweed P.E are as follows: 1:0.4:
0.5:0.4.
Preferably, the Anti-hair loss composition, based on parts by weight, 1-10 parts of inosine, lupin protein hydrolysate 1-
20 parts, 1-5 parts of caffeine, 1-10 parts of L-arginine, 1-4 parts of ornithine, 1-5 parts of small molecule chitosan, Gentrin Knotweed P.E 1-4
Part.
Preferably, the Anti-hair loss composition, based on parts by weight, the Anti-hair loss composition are by following component
Composition:
1-5 parts of inosine, 10-20 parts of lupin protein hydrolysate, 2-5 parts of caffeine, 1-5 parts of L-arginine, ornithine 1-2
Part, 2-4 parts of small molecule chitosan, 1-2 parts of Gentrin Knotweed P.E.
Preferably, it is 2-20 that the small molecule chitosan, which is the degree of polymerization, molecular weight≤3.5kDa chitosan oligomer.
The Anti-hair loss composition is made after mixing each component.
Preferably, for the Anti-hair loss composition in the application for preparing Anti-hair loss and washing in shield product, the Anti-hair loss washes shield
Product is the Anti-hair loss composition by 8-30%；And the additive composition of 70-92%；The Anti-hair loss washes shield its dosage form of product choosing
From hair conditioner, treatment wax, shampoo, hair-care essence liquid, hair mousses or hairdressing approved product.
Preferably, the Anti-hair loss composition prepare Anti-hair loss wash shield product in application, the additive includes:
The moisturizer of 1-5%, the emulsifier of 0.01-3%, the pH adjusting agent of 0.01-0.5%, the surface of 0.01-30% are living
Property agent, the preservative of 0.05-3%, the stabilizer of 0.01-2%, the excipient of 0.01-3%, 0.01-4% conditioner, dilution
Agent surplus.
Preferably, in the application for preparing Anti-hair loss and washing in shield product, the diluent is selected from the Anti-hair loss composition
The mixing of one or both of deionized water, ethyl alcohol；
The moisturizer be selected from hyaluronic acid (sodium), glycerol, propylene glycol, 1,3-BDO, ethoxy urea, allantoin,
One of Anjidew NL50, certain herbaceous plants with big flowers base glucoside are a variety of；
The emulsifier is selected from ethoxylated methyl glucose glucosides stearate, polyoxyethylene sorbitol acid anhydride monostearate
One of ester (tween), fatty glyceride, anhydrous sorbitol mono fatty acid ester, fatty acid citrate acid glyceride are a variety of；
The pH adjusting agent is selected from one of hydrochloric acid, sulfuric acid, citric acid, lactic acid, potassium hydroxide, sodium hydroxide or more
Kind；
The surfactant is selected from laureth sodium sulfovinate, sodium methyl cocoyl taurate, cocounut oil acyl hydroxyl second
One of sulphonic acid ester sodium, sodium cocoamphoacetate, sodium lauroyl sarcosine are a variety of；
The preservative in sodium benzoate, parabens, DMDM hydantoin, Phenoxyethanol, polyalcohol one
Kind is a variety of；
The stabilizer is selected from one of carbomer, cellulose, guar gum, xanthan gum or a variety of；
The excipient is selected from glycol distearate, ethylene glycol stearate, the copolymerization of styrene/acrylic (ester) class
One of object is a variety of；
The conditioner is selected from one of cation guar gum, polyquaternium, silicone grease or a variety of.
The invention has the advantages that and advantageous effects:
The present invention provides a kind of Anti-hair loss composition, including inosine, lupin protein hydrolysate, caffeine, formula components
Simply.Inosine, lupin protein hydrolysate, caffeine are used cooperatively, and are had the effect of apparent alopecia-stopping, are passed through volunteer's
Probationary certificate, after continuous use 10 weeks, the alopecia quantity of tester is significantly reduced, and alopecia-stopping effect is obvious；Meanwhile this group
Closing object also has significant hair regrowth, is mainly to stimulate the stand-down hair follicle cell that hair has fallen off, and activates hair
The function of capsule makes hair follicle cell grow new hair again, and then the effect of play hair tonic, is experimentally confirmed, continuously makes
After 10 weeks, the number of hairs in test zone on the scalp of tester continues to increase, significant effect.
In a kind of Anti-hair loss composition provided by the invention further include: L-arginine, ornithine, small molecule chitosan, tiger
Cane extract；By being used cooperatively for seven kinds of raw materials, effective treatment and the nursing of science are played to the hair follicle cell of scalp
The effect of acting on, being obviously improved product.
Specific embodiment
Below by specific embodiment, the present invention is further explained, but these embodiments are used only for that it is described in more detail
With, and it is not applied to that present invention is limited in any form.
The invention discloses a kind of Anti-hair loss composition and its applications.Anti-hair loss composition of the invention, including inosine, plumage
Fan beans protein hydrolysate (Lupine protein hydrolysate), caffeine.Inosine, lupin protein hydrolysate, caffeine are matched
It closes and uses, there is significant alopecia-stopping effect, meanwhile, this combination also has the function of promoting hair hair tonic, and principle is stimulation head
Hair follicle cell on skin makes the hair follicle cell into dormant period regrow, increases the hair follicle quantity in growth period, and then play life
The effect of hair.
Inosine, also referred to as trophicardyl, inosine are the ucleosides chemical combination being combined by hypoxanthine and ribose
Object.Inosine is the component part of ATP in body, coacetylase, ribonucleic acid and DNA, participates in the metabolism of body
And energetic supersession, the level of body ATP can be improved, a variety of nucleotide can be converted into, and participates in the synthesis of protein, exogenous flesh
After glycosides enters blood, intracellular, activation coacetylase and pyruvate oxidation enzyme can be entered through cell membrane, makes to be in low ATP state
Under cell continuation be successfully metabolized；The symptom of trichomadesis is caused to the degeneration atrophy in scalp due to hair follicle cell,
Supplement inosine appropriate can activate the ATP of hair follicle cell to generate system, hair follicle cell is promoted to develop again, make weight at papilla
Hair newly is grown, to effectively solve alopecia.
Lupin (Lupinus micranthus Guss.) is commonly called as Dull Ice Flower, and phyllopodium generates clump, and palmately compound leaf is by long handle
Like one " feather fan ", lupin of thus gaining the name is 1 year or herbaceos perennial of pulse family Lupinus for support.It is relevant
Research shows that the hydrolysate of lupin -- lupin protein hydrolysate (Lupine protein hydrolysate) has antioxygen
The effect of change, antioxidant activity are related with the amino acid of polypeptide composition and its hydrogen supply electron supplying capacity.Hair follicle in scalp is thin
Due to generating a large amount of free radical by various oxidative pressures, these free radicals being present in hair follicle cell can destroy carefully born of the same parents
The various normal physiological processes of born of the same parents, especially free radical cause the function of cell membrane system to be lost the attack of cell membrane system,
Apoptosis is caused, therefore intake anti-oxidation peptide appropriate can reduce interior free yl level, delay the apoptosis of hair follicle cell,
To reduce falling off for hair.
Studies have shown that there is about 70% to belong to alopecia seborrheica (androgenetic alopecia) in alopecia crowd, i.e., due to
Intracorporal testosterone restores enzyme effect through 5a-, generates dihydrotestosterone (DHT), hair follicle cell is extremely sensitive to DHT, excessively high DHT meeting
It stimulates cell to generate various cell factors (such as TGF-β 2), causes the degeneration, early ageing, atrophy of hair follicle cell, to reduce root of hair
Nutrient supply, final trichomadesis.Confirm that caffeine can help to treat androgenetic alopecia through research, to offset two
Inhibit the negative effect of natural on-off cycles of hair growth caused by hydrogen testosterone, the mechanism to play a role is mostly derived from the work for inhibiting phosphodiesterase
Property, so as to cause the raising of cyclic adenosine monophosphate (cAMP) in courier's compound, to promote hair follicle growth, extend hair growth week
Phase.
Arginine (Arginine) is also known as Argine Monohydrochloride, is amino acids.Studies have shown that arginine is in vivo
The principal mode for playing physiological action is L-arginine；Major function is to participate in the synthesis of protein in arginic physiological function,
Most important one two are respectively:
1) promote wound healing, arginine can promote the synthesis of collagen tissue, therefore can repair wound.In wound exudate
The raising of arginase activities can be observed, this also indicates that the arginine requirement near wound increases；Arginine can promote to hurt
Microcirculation around mouthful, so that wound be promoted to fully recover early.
2) arginine can improve the immune function of body, and arginic opsonic action is mainly shown as up-regulation immunosupress,
Excessively high inflammatory reaction is lowered, the immunologic balance of body is maintained.Scalp hair follicles cell is be easy to cause due to being damaged by external environment
Apoptosis so as to cause the epilation for being rooted in hair follicle cell, therefore supplements arginine for impaired hair follicle cell, can be effective
The healing for accelerating impaired hair follicle cell, achievees the effect that firm hair.
Ornithine is essential mesostate in body metabolism, a kind of nonprotein amino acid.L-Orn
It is one of basic amino acid, L-Orn plays a very important role in the final metabolic cycles of human body nitrogen, can be by human body egg
The ammonia of amino acid, amino acid generation that white matter metabolism generates is converted into urea and detoxifies, and promotes the terminal of nitrogen to be metabolized, promotes urea
Circulation；After ornithine enters the active hair follicle cell of metabolism, the conversion of the ammonia generated into the cell by metabolism can be promoted, be cell
Removing toxic substances, guarantees the eubolism of hair follicle cell.
Chitosan is the product after the chemically treated deacetylation of chitin, is that only alkalinity existing for nature is more
Sugar has good biocompatibility；Studies have shown that the chitosan of small-molecular-weight has effects that restraining and sterilizing bacteria；The temperature of scalp
The microorganisms such as the very suitable fungi of humidity environment, bacterium are in its surface layer growth and breeding, and wherein harmful microorganism is in growth course
In metabolite may scalp cells generate stimulation, cause head to itch, dandruff increases, and then damaged scalp, even hair follicle
Cell, therefore small molecule chitosan is acted on into scalp, can effectively it inhibit, the harmful microorganism on even killing scalp surface layer, from
And reach alleviation head and itch, reduce the effect of dandruff.
Polygonum cuspidate (polyg onum cuspidatum), polygonaceae plant, perennial coarse draft have clearing heat and promoting diuresis, stop
The effect of cough, resolving sputum, promoting blood circulation defaecation, there is therapeutic effect to diseases such as hepatitis, arthritis, pneumonia, blood lipids.Modern pharmacological research table
Bright, the resveratrol in Gentrin Knotweed P.E has the multiple efficacies such as anti-oxidant, anti-inflammatory, and Gentrin Knotweed P.E is acted on scalp hair
Bladder cell removes the living radical in hair follicle cell, alleviates the oxidative pressure of cell, accelerates the healing of impaired hair follicle cell,
Hair follicle cell Metabolism of Normal is carried out, enough nutrition is provided for the growth of hair, keeps hair pitch-black, glossy.
The above component is commercial product.The above component grows generation from hair follicle cell respectively by scientific and reasonable collocation
The tune of energy requirement, alleviation oxidative pressure, the adjusting of hormone, cell metabolism removing toxic substances, the reparation of inflammation and the scalp Tiny ecosystem thanked
The many aspects comprehensive function such as whole, it is more more significant than one-component (or combination of other forms) ingredient effect, comprehensive, it can be effective
Nutrition and energy are provided for the hair follicle cell for the phase of falling off, improves the vigor of hair follicle cell, delays the atrophy of papilla, to prevent
Hair falls off, and stimulates the stand-down hair follicle cell that hair has fallen off, activates the function of hair follicle, makes hair follicle cell again
The effect of growing new hair, and then playing hair tonic, to fundamentally solve the problems, such as alopecia and hair regeneration.
The following are Anti-hair loss compositions to prepare embodiment.
Embodiment 1 (preparation of Anti-hair loss composition)
A kind of Anti-hair loss composition, is made of following material component:
Inosine 1Kg, lupin protein hydrolysate 10Kg, caffeine 4Kg are simply mixed respectively.
Embodiment 2 (preparation of Anti-hair loss composition)
A kind of Anti-hair loss composition, is made of following material component:
Inosine 1Kg, lupin protein hydrolysate 15Kg, caffeine 3Kg are simply mixed respectively.
Embodiment 3 (preparation of Anti-hair loss composition)
A kind of Anti-hair loss composition, is made of following material component:
Respectively by inosine 1Kg, lupin protein hydrolysate 15Kg, caffeine 3Kg, L-arginine 2Kg, ornithine 1Kg, small point
Seed chitosan 2.5Kg, Gentrin Knotweed P.E 2Kg are simply mixed.
Embodiment 4 (preparation of Anti-hair loss composition)
A kind of Anti-hair loss composition, is made of following material component:
Respectively by inosine 1Kg, lupin protein hydrolysate 13Kg, caffeine 4Kg, L-arginine 3Kg, ornithine 1.5Kg, small
Molecular chitosan 3Kg, Gentrin Knotweed P.E 1.5Kg are simply mixed.
It is individually below the Application Example of the Anti-hair loss composition of embodiment 1-4.
Embodiment 5 (shampoo containing Anti-hair loss composition)
A kind of preparation method of Hair-loss-preventingshampoo shampoo, comprising:
1) appropriate amount of deionized water is heated with stirring to 80 DEG C, adds laureth sodium sulfovinate, lauroyl both sexes base
Sodium acetate, Cocoamidopropyl betaine, coconut oleoyl amine MEA, glycol distearate and PEG-7 glyceryl cocoate are protected
Temperature stirring 30min, obtains A phase；
2) guar hydroxypropyltrimonium ammonium chloride is added into appropriate amount of deionized water, after mixing evenly, obtains B phase；
3) B is added in A phase, stirs 15min, then homogeneous 3min, led to cooling water temperature to 45 DEG C, sequentially add implementation
Anti-hair loss composition, preservative described in example 1, EDTA-2Na, citric acid, sodium chloride, essence and remaining deionized water, stirring
30min or more obtains Hair-loss-preventingshampoo shampoo.
In the anticreep shampoo of the present embodiment, deionized water, laureth sodium sulfovinate, lauroyl both sexes guanidine-acetic acid
Sodium, Cocoamidopropyl betaine, coconut oleoyl amine MEA, glycol distearate, PEG-7 glyceryl cocoate, guar gum hydroxyl
Hydroxypropyltrimonium chloride, the Anti-hair loss composition of embodiment 1, preservative, EDTA-2Na, citric acid, sodium chloride and essence
Mass percent are as follows: 70.2:13.5:4.0:5.6:1:1.5:0.3:0.5:0.1:2:0.5:0.1,0.1:0.5:0.2.
Embodiment 6 (hair conditioner containing Anti-hair loss composition)
A kind of preparation method of Anti-hair loss hair conditioner, comprising:
1) suitable deionized water is heated to 80 DEG C, puts into 16/octadecyl alcolol, stearyl trimethyl ammonium chloride, EDTA-
2Na, insulated and stirred 20min, until material is completely dissolved；
2) leading to cooling water makes temperature of charge be down to 50 DEG C, sequentially adds Anti-hair loss composition, the poly dimethyl silicon of embodiment 2
Oxygen alkane, preservative, essence, citric acid continue to stir 30min, and homogeneous 3min continues cool to room temperature, obtain Anti-hair loss hair care
Element.
In the Anti-hair loss hair conditioner of the present embodiment, deionized water, stearyl trimethyl ammonium chloride, is implemented 16/octadecyl alcolol
The mass percent of the Anti-hair loss composition of example 2, dimethyl silicone polymer, preservative, essence, citric acid are as follows: 89.6:5:1.5:
1:2:0.2:0.5:0.2.
Embodiment 7 (Essence containing Anti-hair loss composition)
A kind of preparation method of anticreep hair essence, comprising:
1) at room temperature, cellulose is dissolved in deionized water, obtains A phase；
2) in A phase, Anti-hair loss composition, EDTA-2Na, preservative and essence described in embodiment 3 are sequentially added, stirring is equal
It is even, obtain anticreep hair essence；
In the anticreep hair essence of the present embodiment, deionized water, cellulose, Anti-hair loss composition described in embodiment 3,
The mass percent of EDTA-2Na, preservative and essence are as follows: 95.9:0.1:3:0.1,0.5:0.5.
Comparative example 1
A kind of composition, comprising: L-arginine 5kg, ornithine 2kg, small molecule chitosan 2.5kg, Gentrin Knotweed P.E
1.2kg。
Wherein, the Gentrin Knotweed P.E in above-described embodiment 4-7 and comparative example 1 is commercially available Gentrin Knotweed P.E, raw material form
It can be powder or liquid.
It is 2-20 that small molecule chitosan in above-described embodiment 4-7 and comparative example 1, which is the degree of polymerization, molecular weight≤3.5kDa
Chitosan oligomer.
Compliance test result test example
The effect of in order to verify Anti-hair loss composition disclosed in the present invention, Anti-hair loss group prepared by embodiment 1,2,3,4
The composition for closing object and the preparation of comparative example 1 is prepared as follows into anticreep hair essence:
Anticreep hair essence is the preparation method comprises the following steps: by water, cellulose, EDTA-2Na, essence, preservative, composition or anticreep
It is 96.9:0.5:0.1:1:0.5:1 mixing that composition, which is sent out, according to percentage, is stirred evenly to get anticreep hair essence is arrived.
Include the anticreep hair essence number 1-4 respectively of the Anti-hair loss composition of embodiment 1,2,3 and 4, includes comparison
The anticreep hair essence number 5 of the composition of example 1.
1. effective follicle population and the detection of Anti-hair loss situation
1.1 test settings:
6 groups of test groups are set, number is 1-6 (wherein number 6 be blank group) respectively, every group of 40 tester (including
20 males, 20 women), the age is between 25-55 years old, wherein the alopecia of the male of 30 testers of every group selection
Grade is II-IV type, and the alopecia grade of women is I type or II type.
The classification of male pattern baldness grade:
Male pattern baldness gradually extends to the crown, forehead hairline is shunk back backward, or is from the beginning opened generally since forehead two sides
Beginning alopecia.Alopecia continues, and preceding hair line is retreated from two sides, and forehead is got higher, and forms " great number " being commonly called as.Hair gradual change rareness,
Very thin, newborn hair is more and more thinner, soft powerless.Baldness area skin smooth, it is seen that very thin fine hair on birds or animals hair.Often with furfur, in addition to micro- itch,
Without other subjective symptoms.
I type: normal or normal hair style:
II type: frontal temporal part hair line is triangular in shape to be moved back, and the coronal line away from the connection of two ear canals is up to 2CM；
Type III: two temporo angles are shunk back surmounted coronal line before 2CM, top shows sparse；
IV type: two temporos and hairline are obviously shunk back, and are retreated with hairline in the middle part of volume, but the hair band phase that period has density medium
Every:
V-type: volume temporo and top exposed area expand, and during which hair band is narrow and sparse；
VI type: shape of a hoof alopecia, side and the area of alopecia below increase；
VII type: severe form, in addition to shape of a hoof alopecia, ear week and occipitalia have alopecia.
Female alopecia grade separation:
Female alopecia is mostly that overhead hair diffusivity falls off, so that top hair is gradually sparse, but not is completely fallen off,
It makes slow progress.
1 grade (slight): hair is thinning before coronal area, must change hair style to cover up, forehead hairline line is complete；Second part
The analysis of clinical and experimental study androgenetic alopecia Syndrome Differentiation of Traditional Chinese Medicine and the observation of hair electron microscope experiment；
2 grades (moderate): hair is thinning before coronal area becomes apparent from, and alopecia area range expands, and changes hair style and has been difficult to cover up；
3 grades (severe): top complete alopecia or exposed, but forehead hairline line is still complete
1.2 application methods:
The test group of number 1-5, member is early daily, evening respectively uses an anticreep hair essence, takes 3mL Anti-hair loss smart every time
Essence is applied to scalp at alopecia, and massages 5-10min by magnificent liquid；Blank group, using clear water, other are as test group；
During test, all testers are in addition to the anticreep hair essence for using test, without using the product of other Anti-hair loss.
1.3 effective follicle population testing results:
At the alopecia of tester head, the detection zone that area is 3cm x 3cm is chosen, using hair follicle hair analysis instrument
Divide detection zone of the shooting tester at the 0th week, 2 weeks, 4 weeks, 6 weeks, 8 weeks and 10 weeks, the results are shown in Table 1.
1 hair follicle density of table
From table 1 it follows that tester is using the anti-of the Anti-hair loss composition for including embodiment 1,2,3 and 4
The 2nd week after alopecia Essence, effective follicle population obviously increased, then with using being continuously increased for time, effective hair
Capsule density is also being continuously increased, to prove that Anti-hair loss composition disclosed by the invention can effectively increase the number of effective hair follicle
Mesh, and then demonstrate it there is the effect of effective hair tonic.
1.4 alopecia-stopping effects
Epilation radical when tester combs hair is collected, is collected using the 0th week after anticreep hair essence and the 10th week
It is that the alopecia of tester falls off number, the method collected every time specifically: hair is combed on the double gauze of the 1 meter of square spread out,
The hair adhered on gauze is collected and calculated, the results are shown in Table 2.
Table 2 combs falling out number
From Table 2, it can be seen that tester is using the anti-of the Anti-hair loss composition for including embodiment 1,2,3 and 4
10 weeks after alopecia Essence, the quantity of alopecia is compared with (the 0th week) before use, hence it is evident that decline, it was demonstrated that disclosed by the invention anti-
Alopecia composition can effectively prevent epilation.
The above described is only a preferred embodiment of the present invention, be not intended to limit the present invention in any form, therefore
Without departing from the technical solutions of the present invention, to the above embodiments according to the technical essence of the invention any simply to repair
Change, equivalent variations and modification, all of which are still within the scope of the technical scheme of the invention.
Claims (10)
1. a kind of Anti-hair loss composition, it is characterised in that: including inosine, lupin protein hydrolysate, caffeine；The inosine, plumage
Fan the mass ratio between beans protein hydrolysate, caffeine three are as follows: 1:1-20:1-5.
2. Anti-hair loss composition according to claim 1, it is characterised in that: the inosine, lupin protein hydrolysate, coffee
The mass ratio of cause is 1:2:1 or 1:3:1 or 1:3:2.
3. Anti-hair loss composition according to claim 1 or 2, it is characterised in that: further include L-arginine, ornithine, small
Molecular chitosan, Gentrin Knotweed P.E；The L-arginine, ornithine, small molecule chitosan, the matter between Gentrin Knotweed P.E
Measure ratio are as follows: 1:0.4:0.5:0.4.
4. Anti-hair loss composition according to claim 3, it is characterised in that: based on parts by weight, the Anti-hair loss combination
Object is to be made of the following components:
It is 1-10 parts of inosine, 1-20 parts of lupin protein hydrolysate, 1-5 parts of caffeine, 1-10 parts of L-arginine, 1-4 parts of ornithine, small
1-5 parts of molecular chitosan, 1-4 parts of Gentrin Knotweed P.E.
5. Anti-hair loss composition according to claim 4, it is characterised in that: based on parts by weight, the Anti-hair loss combination
Object is to be made of the following components:
It is 1-5 parts of inosine, 10-20 parts of lupin protein hydrolysate, 2-5 parts of caffeine, 1-5 parts of L-arginine, 1-2 parts of ornithine, small
2-4 parts of molecular chitosan, 1-2 parts of Gentrin Knotweed P.E.
6. Anti-hair loss composition according to claim 1, it is characterised in that: it is 2- that the small molecule chitosan, which is the degree of polymerization,
20, molecular weight≤3.5kDa chitosan oligomer.
7. Anti-hair loss composition of any of claims 1-6, it is characterised in that: be made after mixing each component.
8. Anti-hair loss composition of any of claims 1-6 is in the application for preparing Anti-hair loss and washing in shield product, special
Sign is: it is the Anti-hair loss composition by 8-30% that the Anti-hair loss, which washes shield product,；And the additive composition of 70-92%；It is described
Anti-hair loss washes shield its dosage form of product and is selected from hair conditioner, treatment wax, shampoo, hair-care essence liquid, hair mousses or hairdressing sizing production
Product.
9. application according to claim 8, it is characterised in that: the additive includes:
The moisturizer of 1-5%, the emulsifier of 0.01-3%, the pH adjusting agent of 0.01-0.5%, the surface-active of 0.01-30%
Agent, the preservative of 0.05-3%, the stabilizer of 0.01-2%, the excipient of 0.01-3%, the conditioner of 0.01-4%, diluent
Surplus.
10. application according to claim 9, it is characterised in that:
The diluent is selected from the mixing of one or both of deionized water, ethyl alcohol；
The moisturizer is selected from hyaluronic acid (sodium), glycerol, propylene glycol, 1,3-BDO, ethoxy urea, allantoin, PCA
One of sodium, certain herbaceous plants with big flowers base glucoside are a variety of；
The emulsifier is selected from ethoxylated methyl glucose glucosides stearate, polyoxyethylene sorbitan monostearate
One of (tween), fatty glyceride, anhydrous sorbitol mono fatty acid ester, fatty acid citrate acid glyceride are a variety of；
The pH adjusting agent is selected from one of hydrochloric acid, sulfuric acid, citric acid, lactic acid, potassium hydroxide, sodium hydroxide or a variety of；
The surfactant is selected from laureth sodium sulfovinate, sodium methyl cocoyl taurate, cocounut oil acyl isethionic acid
One of ester sodium, sodium cocoamphoacetate, sodium lauroyl sarcosine are a variety of；
The preservative be selected from one of sodium benzoate, parabens, DMDM hydantoin, Phenoxyethanol, polyalcohol or
It is a variety of；
The stabilizer is selected from one of carbomer, cellulose, guar gum, xanthan gum or a variety of；
The excipient is in glycol distearate, ethylene glycol stearate, styrene/acrylic (ester) analog copolymer
It is one or more；
The conditioner is selected from one of cation guar gum, polyquaternium, silicone grease or a variety of.
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| CN114533586A (en) * | 2021-11-23 | 2022-05-27 | 广州市科能化妆品科研有限公司 | Dandruff-removing itching-relieving shampoo composition, and preparation method and application thereof |
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