CN106265370A - A kind of shampoo effectively preventing pathologic alopecia and preparation method thereof - Google Patents

A kind of shampoo effectively preventing pathologic alopecia and preparation method thereof Download PDF

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CN106265370A
CN106265370A CN201610874686.6A CN201610874686A CN106265370A CN 106265370 A CN106265370 A CN 106265370A CN 201610874686 A CN201610874686 A CN 201610874686A CN 106265370 A CN106265370 A CN 106265370A
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zingiberis recens
rhizoma zingiberis
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CN201610874686.6A
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翟鸿宇
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翟鸿宇
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K8/00Cosmetics or similar toilet preparations
    • A61K8/18Cosmetics or similar toilet preparations characterised by the composition
    • A61K8/19Cosmetics or similar toilet preparations characterised by the composition containing inorganic ingredients
    • A61K8/20Halogens; Compounds thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K8/00Cosmetics or similar toilet preparations
    • A61K8/18Cosmetics or similar toilet preparations characterised by the composition
    • A61K8/30Cosmetics or similar toilet preparations characterised by the composition containing organic compounds
    • A61K8/40Cosmetics or similar toilet preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/44Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K8/00Cosmetics or similar toilet preparations
    • A61K8/18Cosmetics or similar toilet preparations characterised by the composition
    • A61K8/30Cosmetics or similar toilet preparations characterised by the composition containing organic compounds
    • A61K8/40Cosmetics or similar toilet preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/44Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
    • A61K8/442Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof substituted by amido group(s)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K8/00Cosmetics or similar toilet preparations
    • A61K8/18Cosmetics or similar toilet preparations characterised by the composition
    • A61K8/30Cosmetics or similar toilet preparations characterised by the composition containing organic compounds
    • A61K8/46Cosmetics or similar toilet preparations characterised by the composition containing organic compounds containing sulfur
    • A61K8/466Cosmetics or similar toilet preparations characterised by the composition containing organic compounds containing sulfur containing sulfonic acid derivatives; Salts
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K8/00Cosmetics or similar toilet preparations
    • A61K8/18Cosmetics or similar toilet preparations characterised by the composition
    • A61K8/30Cosmetics or similar toilet preparations characterised by the composition containing organic compounds
    • A61K8/58Cosmetics or similar toilet preparations characterised by the composition containing organic compounds containing atoms other than carbon, hydrogen, halogen, oxygen, nitrogen, sulfur or phosphorus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K8/00Cosmetics or similar toilet preparations
    • A61K8/18Cosmetics or similar toilet preparations characterised by the composition
    • A61K8/30Cosmetics or similar toilet preparations characterised by the composition containing organic compounds
    • A61K8/60Sugars; Derivatives thereof
    • A61K8/604Alkylpolyglycosides; Derivatives thereof, e.g. esters
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K8/00Cosmetics or similar toilet preparations
    • A61K8/18Cosmetics or similar toilet preparations characterised by the composition
    • A61K8/30Cosmetics or similar toilet preparations characterised by the composition containing organic compounds
    • A61K8/64Proteins; Peptides; Derivatives or degradation products thereof
    • A61K8/65Collagen; Gelatin; Keratin; Derivatives or degradation products thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K8/00Cosmetics or similar toilet preparations
    • A61K8/18Cosmetics or similar toilet preparations characterised by the composition
    • A61K8/72Cosmetics or similar toilet preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73Polysaccharides
    • A61K8/731Cellulose; Quaternized cellulose derivatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K8/00Cosmetics or similar toilet preparations
    • A61K8/18Cosmetics or similar toilet preparations characterised by the composition
    • A61K8/72Cosmetics or similar toilet preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/84Cosmetics or similar toilet preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
    • A61K8/89Polysiloxanes
    • A61K8/891Polysiloxanes saturated, e.g. dimethicone, phenyl trimethicone, C24-C28 methicone or stearyl dimethicone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K8/00Cosmetics or similar toilet preparations
    • A61K8/18Cosmetics or similar toilet preparations characterised by the composition
    • A61K8/92Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A61K8/922Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K8/00Cosmetics or similar toilet preparations
    • A61K8/18Cosmetics or similar toilet preparations characterised by the composition
    • A61K8/96Cosmetics or similar toilet preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toilet preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILET PREPARATIONS
    • A61Q5/00Preparations for care of the hair
    • A61Q5/002Preparations for repairing the hair, e.g. hair cure
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILET PREPARATIONS
    • A61Q5/00Preparations for care of the hair
    • A61Q5/006Antidandruff preparations
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILET PREPARATIONS
    • A61Q5/00Preparations for care of the hair
    • A61Q5/02Preparations for cleaning the hair
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILET PREPARATIONS
    • A61Q7/00Preparations for affecting hair growth
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/59Mixtures
    • A61K2800/592Mixtures of compounds complementing their respective functions
    • A61K2800/5922At least two compounds being classified in the same subclass of A61K8/18

Abstract

The invention belongs to washing product field, particularly disclose a kind of shampoo effectively preventing pathologic alopecia and preparation method thereof.This effectively prevents the shampoo of pathologic alopecia, make with collagen protein powder, Rhizoma Zingiberis Recens, Radix Ginseng, Bulbilus boussingaultiae pseudobaselloidis, Cortex Dictamni, Fructus Gleditsia, Cacumen Platycladi, Cortex Albiziae, Semen Sesami Nigrum, grass, bamboo salt, Flos Chrysanthemi Indici, Rhizoma Polygonati Odorati, Pericarpium Granati, Semen Armeniacae Amarum, Exocarpium Citri Rubrum, alkyl polyglucoside, Zinc Pyrithione, hydroxypropyl methyl cellulose, amino acid humectant, dodecylbenzene sodium sulfonate, lauroyl lysine, emulsified silicone oil, cocamido propyl betaine, Kazon, macadamia nut oil, rosemary ethereal oil, Jojoba oil, deionized water for raw material, safe and non-stimulating to hair and scalp.This effectively prevents the shampoo of pathologic alopecia, plurality of raw materials is coordinated, and utilizes the collaborative or resistant function that it is mutual, improves its hair care hair care, effect of Anti-hair loss, can effectively facilitate scalp blood microcirculation, improve scalp own metabolism.

Description

A kind of shampoo effectively preventing pathologic alopecia and preparation method thereof

Technical field

The invention belongs to washing product field, particularly to a kind of shampoo effectively preventing pathologic alopecia and preparation thereof Method.

Background technology

Alopecia is the phenomenon of alopecia, have physiological and pathologic point.Physiologic alopecia refers to that hair takes off normally Falling, generally falling five or six ten hairs every day is normal phenomenon, and having spent 50 years old also can increase to every day about 150.Pathology Property alopecia is the hair diseases that a kind of clinic is common, and according to incompletely statistics, hair loss patient accounts for the 20%-of adult population 30%, spirit and mental health to people produce strong influence.Youngster alopecia every day is a dangerous letter more than 100 Number, if this situation continues two or three months, just it is likely to suffer from alopecia.

The quickening with rhythm of life is constantly increased, the continuous deterioration of environment, and bad diet habit along with social pressure Used, also grow with each passing day with our non-health, subhealth state, the hair loss patient of China gets more and more.Add due in work Pressure, a lot of people to self image require more and more higher, especially hair, at work, a lot of people in order to promote from Oneself overall image, usually can select hair-waving, hair dyeing etc., hair-waving again and again always to make hair quality become withered and yellow, fall with hair dyeing Send out, bifurcated, coarse, easily broken easy to fall off etc., hair is caused fatal harm.Naturally, in actual life, more People suffered from serious alopecia phenomenon, often washing a hair all can have up to a hundred the most hundreds of hairs to take off, alopecia problem Become the first big hair health problem of puzzlement people.

In daily life, shampoo is one of conventional washing product, is to have the cleaning function such as hair, removing scurf and relieving itching Hair products.The main component of traditional shampoo is industrial chemicals, but in order to meet the difference in functionality demand of consumer, Many enterprises with the addition of multiple harmful composition wherein, and as silicon sodium etc., life-time service can block scalp hair follicles and hair scale sheet, enters And cause dandruff to increase, the easily broken phenomenon such as easy to fall off of hair quality.

Containing more preservative in shampoo the most on sale, scalp is had certain zest, meeting after hair washing Scalp itch, in some instances it may even be possible to concurrently shave one's head, the sequela such as alopecia.In the face of present situation, we need a kind of effective anti-alopecia-stopping, anti-dandruff badly Antipruritic shampoo.

Summary of the invention

The present invention is in order to make up the deficiencies in the prior art, it is provided that a kind of gentleness is non-stimulated, removing scurf and relieving itching, anti-alopecia-stopping A kind of shampoo effectively preventing pathologic alopecia.

The present invention is achieved through the following technical solutions:

A kind of shampoo effectively preventing pathologic alopecia, its active component is made up of the raw material of following parts by weight: glue Former egg albumen powder 12-15 part, Rhizoma Zingiberis Recens 12-14 part, Radix Ginseng 3-6 part, Bulbilus boussingaultiae pseudobaselloidis 9-12 part, Cortex Dictamni 12-15 part, Fructus Gleditsia 9-13 part, Cacumen Platycladi 12-15 part, Cortex Albiziae 10-13 part, Semen Sesami Nigrum 12-15 part, grass 8-12 part, bamboo salt 6-9 part, Flos Chrysanthemi Indici 14-18 part, Rhizoma Polygonati Odorati 7-11 part, Pericarpium Granati 8-12 part, Semen Armeniacae Amarum 7-10 part, Exocarpium Citri Rubrum 10-13 part, alkyl polyglucoside 5-7 part, Zinc Pyrithione 2-4 part, Hydroxypropyl methyl cellulose 4-7 part, amino acid humectant 4-6 part, dodecylbenzene sodium sulfonate 6-8 part, lauroyl lysine 6-8 Part, emulsified silicone oil 3-5 part, cocamido propyl betaine 1.8-2.5 part, Kazon 1.6-1.9 part, macadamia nut oil 3.4-4.6 part, fan Repeatedly essential oil 2.4-3.2 part, Jojoba oil 1.8-2.6 part, deionized water 35-43 part.

Preferably, the parts by weight of each active component are: collagen protein powder 14 parts, 13 parts of Rhizoma Zingiberis Recens, Radix Ginseng 5 parts, Bulbilus boussingaultiae pseudobaselloidis 11 parts, Cortex Dictamni 14 parts, Fructus Gleditsia 11 parts, Cacumen Platycladi 14 parts, Cortex Albiziae 12 parts, Semen Sesami Nigrum 14 parts, grass 10 parts, bamboo salt 8 parts, wild Flos Chrysanthemi 16 parts, Rhizoma Polygonati Odorati 9 parts, Pericarpium Granati 10 parts, 9 parts of Semen Armeniacae Amarum, Exocarpium Citri Rubrum 12 parts, alkyl polyglucoside 6 parts, Zinc Pyrithione 3 parts, hydroxypropyl Methylcellulose 6 parts, amino acid humectant 5 parts, dodecylbenzene sodium sulfonate 7 parts, lauroyl lysine 7 parts, emulsified silicone oil 4 Part, cocamido propyl betaine 2.2 parts, Kazon 1.8 parts, macadamia nut oil 4.2 parts, rosemary ethereal oil 2.8 parts, Jojoba oil 2.2 Part, deionized water 39 parts.

A kind of preparation method of the shampoo effectively preventing pathologic alopecia, step is as follows:

(1) Bulbilus boussingaultiae pseudobaselloidis and Fructus Gleditsia are placed in glass container, add 4-6 times of Bulbilus boussingaultiae pseudobaselloidis and 28-32 ° of rice of Fructus Gleditsia quality sum Wine, places 2-4 days at a temperature of 35-45 DEG C, filters, obtains the Bulbilus boussingaultiae pseudobaselloidis after moistening and Fructus Gleditsia;By the Bulbilus boussingaultiae pseudobaselloidis after moistening and Fructus Gleditsia is placed in non iron frying pan, adds Semen Sesami Nigrum and Semen Armeniacae Amarum, and moderate heat stir-fries 30-40 minute, dries, and pulverizes, and crosses 100-140 mesh Sieve;

(2) Cortex Dictamni, Cacumen Platycladi, grass, Rhizoma Polygonati Odorati and Exocarpium Citri Rubrum are placed in frying pan, add 2-4 times of Cortex Dictamni, Cacumen Platycladi, Grass, Rhizoma Polygonati Odorati and the Testa Tritici of Exocarpium Citri Rubrum quality sum, moderate heat stir-fries 30-40 minute, takes out, cools, and sieve removes Testa Tritici, and must process is white Cortex Dictamni, Cacumen Platycladi, grass, Rhizoma Polygonati Odorati and Exocarpium Citri Rubrum;

(3) Rhizoma Zingiberis Recens is pounded Rhizoma Zingiberis Recens mud, is placed in squeezer, add macadamia nut oil, squeeze under the rotating speed of 75-85 rev/min Extracting juice, obtains the first Sucus Zingberis;Add the pure water of 2-4 times of Rhizoma Zingiberis Recens dregs quality, in squeezer under the rotating speed of 75-85 rev/min again Secondary squeezing, obtain the second Sucus Zingberis, merge the first Sucus Zingberis and the second Sucus Zingberis, when being concentrated into 55 DEG C-65 DEG C, relative density is 1.12- The Rhizoma Zingiberis Recens cream of 1.16, gained Rhizoma Zingiberis Recens cream and Rhizoma Zingiberis Recens dregs are standby;

(4) step (3) gained Rhizoma Zingiberis Recens dregs is placed in glass container, adds the rice vinegar of 4-6 times of Rhizoma Zingiberis Recens dregs quality, mix thoroughly, 2 DEG C of-6 DEG C lower seal cold preservations 3-5 hour, are placed in the Rhizoma Zingiberis Recens dregs after cold preservation in Chinese medicine extracting tank, add Radix Ginseng, Cortex Albiziae, Flos Chrysanthemi Indici And Pericarpium Granati, add 7-10 times of Radix Ginseng, Cortex Albiziae, Flos Chrysanthemi Indici and the water of Pericarpium Granati quality sum, extract 40-50 minute, obtain filtering residue And extracting solution;

(5) step (4) gained filtering residue is again placed in the Chinese medicine extracting tank that step (4) uses, adds step (2) gained Cortex Dictamni, Cacumen Platycladi, grass, Rhizoma Polygonati Odorati and the Exocarpium Citri Rubrum processed, adds 4-7 times of Cortex Dictamni, Cacumen Platycladi, grass, Rhizoma Polygonati Odorati and Exocarpium Citri Rubrum The water of quality sum, extracts twice, extracts 45-55 minute, united extraction liquid every time, mixes with the extracting solution of step (4) gained, quiet Put 3-5 hour, filter, obtain medicinal liquid;Collagen protein powder, amino acid humectant and Kazon, mix homogeneously is added in gained medicinal liquid;

(6) bamboo salt is pulverized, be placed in dissolving tank, add deionized water, stir and be completely dissolved to bamboo salt, add hydroxypropyl Methylcellulose, dodecylbenzene sodium sulfonate, lauroyl lysine and step (1) gained sieve after powder, delay while stirring Slowly being heated to temperature and be 60-70 DEG C, isothermal holding, after 2-3 hour, is cooled to when 24-28 DEG C add alkyl polyglucoside, pyrithione Zinc, cocamido propyl betaine and step (3) gained Rhizoma Zingiberis Recens cream, mix homogeneously, isothermal holding 2-4 hour;

(7) by step (5) products therefrom and step (6) products therefrom mix homogeneously, emulsified silicone oil is added, the most slowly Stir 20-30 minute, at 38 DEG C-43 DEG C, be concentrated into the thick liquid that relative density is 1.15-1.25, add rosemary ethereal oil and Jojoba oil, stirs, and sterilizes 20-30 minute at 130-150 DEG C, and addition sodium citrate, until pH value is 5.8-6.3, stirs Mix uniformly, encapsulation, obtain the described shampoo effectively preventing pathologic alopecia.

Usage and dosage: after being drenched by hair, takes appropriate shampoo and is placed in after the palm of the hand crumples out a little foam to repaste and is put on head On Faing, clean with clear water after 1-2 minute.

The pharmaceutical characteristic of each active component of the present invention is as follows:

Collagen protein powder: the collagen protein powder i.e. powderous preparations of collagen protein, collagen protein is the important set of human body protein Become one of composition, play and support organ, the effect of protection body.Collagen protein adds in cosmetics, good with other material combination, Synergy is good, repair that can be the best to impaired skin.

Rhizoma Zingiberis Recens: acrid in the mouth, slightly warm in nature.Return lung, spleen, stomach warp.Rhizoma Zingiberis Recens is the fresh rhizome of zingiber.Have induce sweat scattered Cold, warming middle-JIAO to arrest vomiting, effect of preventing phlegm from forming and stopping coughing.For anemofrigid cold, gastrofrigid vomiting, cold-phlegm is coughed.

Radix Ginseng: sweet in the mouth, micro-hardship, property is put down.Return spleen, lung, heart channel.Radix Ginseng is the dry root and rhizome of Araliaceae Radix Ginseng. Having strongly invigorating primordial QI, multiple arteries and veins takes off admittedly, and invigorating the spleen to benefit the lung promotes the production of body fluid, the effect calmed the nerves.For weak body and prostration, cold extremities faint pulse, insufficiency of the spleen food Few, the deficiency of the lung is breathed with cough, and Tianjin wound is thirsty, and interior-heat is quenched one's thirst, and prolonged illness void is won, palpitation with fear insomnia, heart failure, cardiogenic shock.

Bulbilus boussingaultiae pseudobaselloidis: mildly bitter flavor, warm in nature.For the dry tumor mass shape bulbil on Basellaceae plant Herba basellae rubrae potato rattan.There is the kidney invigorating strong Waist, effect of dissipating blood stasis for subsidence of swelling.For waist knee joint arthralgia pain, the most weak, traumatic injury, fracture.

Cortex Dictamni: bitter in the mouth, salty, cold in nature.Return spleen, lung, small intestinal, stomach, bladder warp.Cortex Dictamni is that Rutaceae perennial herb is planted Thing shaggy-fruited dittany and the root bark of Dictamnus angustifolius.There is heat clearing and damp drying, dispelling wind for relieving itching, effect of removing toxic substances.For the wind caused by wind heat noxious dampness Rash, eczema, scabies, jaundice.

Fructus Gleditsia: acrid in the mouth, warm in nature.Fructus Gleditsia is the fruit of leguminous plant Fructus Gleditsia, containing triterpenoid saponin, tannin, also containing ceryl alcohol, 29 Alkane, stigmasterol, sitosterol etc..There is the expectorant that dispels the wind, dehumidifying poison, effect of parasite killing.For apoplexy facial hemiparalysis, wind syndrome of head is had a headache, is coughed Coughing phlegm dyspnea, discharging fresh blood stool, dysentery keeps silent mouth, carbuncle inguinal bubo.

Cacumen Platycladi: bitter in the mouth, puckery, cold in nature.Return lung, liver, spleen channel.Cacumen Platycladi is the dry branch tip and leaf of Cupressaceae plant Cacumen Platycladi. There is cooling blood for hemostasis, effect of growing and blacking hair.For spitting blood, spitting of blood, have blood in stool, metrostaxis, heat in blood alopecia, early whitening of beard and hair.

Cortex Albiziae: sweet in the mouth, property is put down.GUIXIN, liver, lung meridian.Cortex Albiziae is the dry bark of leguminous plant Herba Albiziae.There is resolving depression Calm the nerves, effect of promoting blood circulation and detumescence.For irritability, melancholy insomnia, lung abscess skin ulcer swells, falls and flutter the pain of injury.

Semen Sesami Nigrum: sweet in the mouth, property is put down.Return liver,spleen,kidney warp.Semen Sesami Nigrum is the black seeds of Pedaliaceae plant Semen Sesami.There is benefit Liver and kidney tonifying, the benefit that nourishes blood essence, effect of loosening bowel to relieve constipation.Early send out for the dizziness and tinnitus caused by deficiency of the liver and kindey, beard and hair, scaly dry skin, Dryness of the intestine constipation, married woman's breast is few, ulcerative carbuncle eczema, infantile scrofula, burn, hemorrhoid.

Grass: sweet in the mouth, hardship, cold in nature.Return lung, kidney channel.Grass is the herb of Moraceae grass platymiscium grass.Containing reseda Element, glycoside, choline, agedoite and volatile oil etc..There is heat-clearing and toxic substances removing, effect of inducing diuresis for treating stranguria syndrome.For cough due to lung-heat, Lung abscess, deficiency-heat excessive thirst, pyretic stranguria, edema, dysuria, damp-heat dysentery, pathopyretic ulcer, skin pruritus.

Bamboo salt: bamboo salt is to be evaporated brine day in the triennial QINGZHU of loading, and two ends are sealed with natural loess, with pinaster for combustion Material, the material extracting after 1000 DEG C of-1500 DEG C of high-temperature calcinations.There is the effects such as antibacterial, antiinflammatory.It is mainly composed of chlorination Sodium, containing micro-calcium, potassium, copper, ferrum, zinc etc. and other trace element.Inflammation is had the curative effect of brilliance, especially to skin surface Various inflammation have extremely strong antiinflammatory, bactericidal action.

Flos Chrysanthemi Indici: bitter in the mouth, pungent, cold nature.Return liver, heart channel.Flos Chrysanthemi Indici is the dry capitulum of feverfew Herba Dendranthematis indici.Tool There is effect of heat-clearing and toxic substances removing.For diseases such as furuncle carbuncle, laryngopharynx swelling and pain, wind-fire acute conjunctivitis, headache dizziness.Have again well simultaneously Hypotensive effect, can be used for the auxiliary treatment of hypertension.To staphylococcus aureus, diphtheria corynebacterium, streptococcus, bacillus pyocyaneus, Influenza virus, all has inhibitory action.

Rhizoma Polygonati Odorati: sweet in the mouth, cold nature.Attach to the lung and stomach meridians.Rhizoma Polygonati Odorati is the dry rhizome of liliaceous plant Rhizoma Polygonati Odorati.There is yin nourishing profit Dry, effect of promoting the production of body fluid to quench thirst.Hindering for lung stomach-Yin, cough caused by dryness-heat, swallow in thirsty, interior-heat is quenched one's thirst.

Pericarpium Granati: sour in the mouth, puckery, warm in nature.Return kidney channel.Pericarpium Granati is the peel of Punicaceae plant Punica granatum L..There is astringing intestine to stop diarrhea, only Blood, effect of anthelmintic.For chronic diarrhea, chronic dysentery, have blood in stool, proctoptosis, spermatorrhea, metrorrhagia, leukorrhagia, abdominal pain due to worm stagnation, scabies.

Semen Armeniacae Amarum: bitter in the mouth, slightly warm in nature.Semen Armeniacae Amarum rich in proteins, fat, saccharide, carotene, vitamin B group, vitamin C, The nutritional labelings such as Citrin and calcium, phosphorus, ferrum.Semen Armeniacae Amarum contains abundant fatty oil, has the effect reducing cholesterol;In the traditional Chinese medical science Pharmacology opinion thinks that Semen Armeniacae Amarum has promoting the production of body fluid to quench thirst, effect of lung moistening Dingchuan, is usually used in the dryness of the lung and the health care of patient and the treatment such as breathes with cough.

Exocarpium Citri Rubrum: acrid in the mouth, hardship, warm in nature.Return lung, spleen channel.Exocarpium Citri Rubrum is the dry outer layer of rutaceae orange and variety thereof Peel.There is cold expelling, dampness, promoting the circulation of QI, effect of expectorant.For cough due to wind and cold, itching of the throat abundant expectoration, food stagnation is got sick from drinking too much wine.

Alkyl polyglucoside: alkyl polyglucoside is synthesized by Renewable resource natural fat alcohol and glucose, be a kind of performance relatively Comprehensively nonionic surfactant, has high surface, good ecological security and intermiscibility.Its surface tension is low, Wetting power is strong, strong detergency, foaming abundancy are fine and smooth, non-stimulated to skin, and biodegradation is thorough rapidly, can be with any type surface Activating agent compounds, and cooperative effect is obvious.Having stronger broad spectrum antibiotic activity, thickening effect is notable, easy to use.

Zinc Pyrithione: Zinc Pyrithione is a kind of chelate, is effectively anti-mildew and antibacterial compound, anti-head Scurf activity is the strongest.For shampoo dandruff, the growth of Gram-positive, negative bacteria and mycete can be suppressed.Can be effective Ground hair conditioning, delays the aging of hair, controls poliosis and the generation of alopecia.

Hydroxypropyl methyl cellulose: hydroxypropyl methyl cellulose be the gossypin selecting high purity as raw material, Prepare through special etherificate under the conditions of alkalescence.Hydroxypropyl methyl cellulose is white or off-white powder, is widely used in leather, paper Goods industry, preserving fruit and vegetable utilizing and textile industry etc..

Amino acid humectant: purchased from Xuancheng Jingrui New Material Co., Ltd., model is the aminoacid of JRSN50Aminocoat Wetting agent, main component is the sweet amino proline of natural methyl group.Amino acid humectant is the efficient guarantor of a kind of amphoteric ion type Humectant, can improve rapidly the moisture holding capacity of skin and hair in cosmetics and washing series products, the vigor of activated cell, There is holding skin moisten, smooth, prevent the effect of xerosis cutis and obfuscation.

Dodecylbenzene sodium sulfonate: dodecylbenzene sodium sulfonate is white or faint yellow powdery or chip solid, mainly uses Making anionic surfactant, have good surface activity, hydrophilic is relatively strong, effectively reduces the tension force of oil-water interface, reaches To emulsification.Wide application is obtained in the emulsion preparations such as cosmetics, food, printing and dyeing assistant, pesticide.

Lauroyl lysine: lauroyl lysine is to be synthesized and through isolated and purified gained by lauric acid and 1B, Raw material sources, in natural, have good biological degradability.Lauroyl lysine has high-lubricity, soft and smooth skinfeel, low mill Wipe coefficient, there is antistatic, non-oxidizability.For color make-up, cosmetics powder handling, give powder body and well paste skinfeel, soft and smooth Sense and hydrophobicity.

Emulsified silicone oil: emulsified silicone oil is white viscous liquid, has the chemical stability of excellence, heat-resisting tolerance to cold, lubrication Property, hydrophobicity and low surface tension, harmless to human non-toxic, it is widely used in personal nursing, food production, fermentation industry etc..With When solving wet comb in shampoo, hair and a difficult problem for the astringent sense of shampoo contact site, have conditioning effect of significantly defending the doctrine Really, hair is made to have a silk quality soft feeling of uniqueness, soft and high resilience, hair non-greasy, it is suitable for life-time service.Life-time service can So that hair keeps unique silk quality logic soft, superpower.

Cocamido propyl betaine: cocamido propyl betaine is a kind of amphoteric surfactant, has good Cleaning, foaming, thickening, opsonic action, performance is gentle, and bactericidal effect is good, it is adaptable to configuration shampoo, bath gel, cleansing milk etc., can Strengthen hair, the flexibility of skin.

Kazon: Kazon is white solid, can be miscible with chlorine and most of anions and canons and nonionic surfactant. Kazon is the sterilization antiseptic of a kind of broad-spectrum, can effectively kill algae, antibacterial and fungus.It is widely used in industrial colling, oil field Return tank water, paper industry, pipeline, coating, paint, rubber and cosmetics, photographic film and articles for washing.

Macadamia nut oil: macadamia nut oil contains abundant fatty acid, sterol, vitamin e and phenolic compound.Fatty acid maintains human body to be good for The hydration levels of health, and linoleic acid is applied on skin anti-inflammatory, reduces acne, moisture-keeping functions has positive effect, ties up him When life E lacks, hair dries up, alopecia.Macadamia nut oil, possibly together with rare plant sterol, can help softening skin, stimulates pore row Poison, recovers natural lipid barrier.

Rosemary ethereal oil: rosemary ethereal oil is colourless to faint yellow volatile liquid, uses the way of distillation to obtain, Herba Rosmarini Officinalis pair Respiratory system is the most helpful, and can promote memory, makes that people is clearheaded, has clear presentation, it may also be used for pain relieving, rheumatism of releiving Bitterly, gout etc..Nursing one's health greasy unclean skin, blood circulation promoting, stimulating hair regenerates.

Jojoba oil: Jojoba oil extracts from the fruit of simmondsia, for the transparent oily liquid of colorless and odorless.Main one-tenth Dividing is unsaturated higher alcohol and fatty acid, has good stability, easily merges with skin, have non-oxidizability free from worldly cares, and Greasy feeling is not stayed after with.It addition, possibly together with abundant vitamin, have and nourish the effect softening skin.In cosmetics, can make Become all kinds of hair care, skin protection, shower sun-proof and medical product.

Deionized water: refer to the pure water after eliminating in ionic species impurity, deionized water is removed completely or by halves Ionic species refers mainly to use ion exchange resin treatment method.The electrolyte that ion in water generally dissolves, comprise as calcium, The aniones such as the cationes such as magnesium, potassium, sodium and carbonate, sulfate radical, chlorate anions, the existence of these electrolyte can affect production technology In product quality, therefore each processing method need to be used to remove.

The Advantageous Effects of the present invention

1, a kind of shampoo effectively preventing pathologic alopecia of the present invention, with many Chinese herbal medicine as main component, by multiple Raw material coordinates, and utilizes the collaborative or resistant function that it is mutual, improves its hair care hair care, effect of Anti-hair loss, can effectively facilitate Scalp blood microcirculation, raising scalp own metabolism;Gentle non-stimulated, when hair, affinity is strong, it is provided that splendid moisturizing Performance, improves damaged hair, can the effective phenomenon such as maintenance hair jag, alopecia.

2, a kind of shampoo effectively preventing pathologic alopecia of the present invention, with Chinese herbal medicine as primary raw material, with the addition of quantitatively Hydroxypropyl methyl cellulose, amino acid humectant, dodecylbenzene sodium sulfonate, emulsified silicone oil, cocamido propyl betaine Form Deng composition is refined, use different processing modes according to the character of all raw materials, and for the Chinese herbal medicine used, according to all The pharmacology of Chinese herbal medicine uses different process, stir-fries after such as Bulbilus boussingaultiae pseudobaselloidis and Fructus Gleditsia one being reinstated 28-32 ° of rice wine moistening, Radix Ginseng, Cortex Albiziae, Flos Chrysanthemi Indici and Pericarpium Granati and Rhizoma Zingiberis Recens dregs are together carried out effective component extracting, and Cortex Dictamni, Cacumen Platycladi, grass, Rhizoma Polygonati Odorati and Exocarpium Citri Rubrum first carry out the common effective component extracting of filtering residue in operating again after parched with bran with other so that effective one-tenth of all raw materials Divide and preferably obtain extraction etc., effectively nourish hair care, removing scurf and relieving itching, improve the elasticity of hair quality, reduce alopecia.Additionally, the present invention The shampoo effectively preventing pathologic alopecia has natural, safety non-toxic, actual effect, the advantage having no side effect.

Detailed description of the invention

Below in conjunction with embodiment, the invention will be further described, but the invention is not limited in this, the system in embodiment Preparation Method is customary preparation methods, no longer describes in detail.

Embodiment 1: this effectively prevents the shampoo of pathologic alopecia, the raw material taking following portions by weight is prepared from (every Part takes 30kg): collagen protein powder 12 parts, 12 parts of Rhizoma Zingiberis Recens, Radix Ginseng 3 parts, Bulbilus boussingaultiae pseudobaselloidis 9 parts, Cortex Dictamni 12 parts, Fructus Gleditsia 9 parts, Cacumen Platycladi 12 parts, Cortex Albiziae 10 parts, Semen Sesami Nigrum 12 parts, grass 8 parts, bamboo salt 6 parts, Flos Chrysanthemi Indici 14 parts, Rhizoma Polygonati Odorati 7 parts, Pericarpium Granati 8 parts, Semen Armeniacae Amarum 7 Part, Exocarpium Citri Rubrum 10 parts, alkyl polyglucoside 5 parts, Zinc Pyrithione 2 parts, hydroxypropyl methyl cellulose 4 parts, amino acid humectant 4 parts, ten 6 parts of dialkyl benzene sulfonic acids sodium, lauroyl lysine 6 parts, emulsified silicone oil 3 parts, cocamido propyl betaine 1.8 parts, Kazon 1.6 Part, macadamia nut oil 3.4 parts, rosemary ethereal oil 2.4 parts, Jojoba oil 1.8 parts, deionized water 35 parts.

The preparation method of the above-mentioned shampoo effectively preventing pathologic alopecia, step is as follows:

(1) Bulbilus boussingaultiae pseudobaselloidis and Fructus Gleditsia are placed in glass container, add 30 ° of rice wine of 5 times of Bulbilus boussingaultiae pseudobaselloidiss and Fructus Gleditsia quality sum, Place 3 days at a temperature of 40 DEG C, filter, obtain the Bulbilus boussingaultiae pseudobaselloidis after moistening and Fructus Gleditsia;Bulbilus boussingaultiae pseudobaselloidis after moistening and Fructus Gleditsia are placed in non- In iron cooking pot, adding Semen Sesami Nigrum and Semen Armeniacae Amarum, moderate heat stir-fries 35 minutes, dries, and pulverizes, and crosses 120 mesh sieves;

(2) Cortex Dictamni, Cacumen Platycladi, grass, Rhizoma Polygonati Odorati and Exocarpium Citri Rubrum are placed in frying pan, add 3 times of Cortex Dictamni, Cacumen Platycladi, Grass, Rhizoma Polygonati Odorati and the Testa Tritici of Exocarpium Citri Rubrum quality sum, moderate heat stir-fries 35 minutes, takes out, cools, and sieve removes Testa Tritici, the Cortex Dictamni that must process, Cacumen Platycladi, grass, Rhizoma Polygonati Odorati and Exocarpium Citri Rubrum;

(3) Rhizoma Zingiberis Recens is pounded Rhizoma Zingiberis Recens mud, is placed in squeezer, add macadamia nut oil, squeeze under the rotating speed of 80 revs/min and take Juice, obtains the first Sucus Zingberis;In squeezer, add the pure water of 3 times of Rhizoma Zingiberis Recens dregs quality, again press under the rotating speed of 80 revs/min Squeezing, obtain the second Sucus Zingberis, merge the first Sucus Zingberis and the second Sucus Zingberis, when being concentrated into 60 DEG C, relative density is the Rhizoma Zingiberis Recens cream of 1.14, gained Rhizoma Zingiberis Recens Cream and Rhizoma Zingiberis Recens dregs are standby;

(4) step (3) gained Rhizoma Zingiberis Recens dregs is placed in glass container, adds the rice vinegar of 5 times of Rhizoma Zingiberis Recens dregs quality, mix thoroughly, at 4 DEG C Seal cold preservation 4 hours, the Rhizoma Zingiberis Recens dregs after cold preservation be placed in Chinese medicine extracting tank, add Radix Ginseng, Cortex Albiziae, Flos Chrysanthemi Indici and Pericarpium Granati, Add 8 times of Radix Ginsengs, Cortex Albiziae, Flos Chrysanthemi Indici and the water of Pericarpium Granati quality sum, extract 45 minutes, obtain filtering residue and extracting solution;

(5) step (4) gained filtering residue is again placed in the Chinese medicine extracting tank that step (4) uses, adds step (2) gained Cortex Dictamni, Cacumen Platycladi, grass, Rhizoma Polygonati Odorati and the Exocarpium Citri Rubrum processed, adds 6 times of Cortex Dictamni, Cacumen Platycladi, grass, Rhizoma Polygonati Odorati and Exocarpium Citri Rubrum matter The water of amount sum, extracts twice, extracts 50 minutes, united extraction liquid every time, mixes with the extracting solution of step (4) gained, stands 4 little Time, filter, obtain medicinal liquid;Collagen protein powder, amino acid humectant and Kazon, mix homogeneously is added in gained medicinal liquid;

(6) bamboo salt is pulverized, be placed in dissolving tank, add deionized water, stir and be completely dissolved to bamboo salt, add hydroxypropyl Methylcellulose, dodecylbenzene sodium sulfonate, lauroyl lysine and step (1) gained sieve after powder, delay while stirring Slowly being heated to temperature is 65 DEG C, and isothermal holding, after 3 hours, is cooled to when 26 DEG C add alkyl polyglucoside, Zinc Pyrithione, cocos nucifera oil acyl Amine CAB and step (3) gained Rhizoma Zingiberis Recens cream, mix homogeneously, isothermal holding 3 hours;

(7) by step (5) products therefrom and step (6) products therefrom mix homogeneously, emulsified silicone oil is added, the most slowly Stir 25 minutes, at 41 DEG C, be concentrated into the thick liquid that relative density is 1.2, add rosemary ethereal oil and Jojoba oil, stirring Uniformly, at 140 DEG C sterilize 25 minutes, add sodium citrate until pH value is 6.1, stir, encapsulation, obtain described effectively Prevent the shampoo of pathologic alopecia.

Usage and dosage: after being drenched by hair, takes appropriate shampoo and is placed in after the palm of the hand crumples out a little foam to repaste and is put on head On Faing, clean with clear water after 1-2 minute.

Embodiment 2: this effectively prevents the shampoo of pathologic alopecia, its active component is made up of the raw material of following weight (every part takes 15kg): collagen protein powder 15 parts, 14 parts of Rhizoma Zingiberis Recens, Radix Ginseng 6 parts, Bulbilus boussingaultiae pseudobaselloidis 12 parts, Cortex Dictamni 15 parts, Fructus Gleditsia 13 parts, Cacumen Platycladi 15 parts, Cortex Albiziae 13 parts, Semen Sesami Nigrum 15 parts, grass 12 parts, bamboo salt 9 parts, Flos Chrysanthemi Indici 18 parts, Rhizoma Polygonati Odorati 11 parts, Pericarpium Granati 12 parts, 10 parts of Semen Armeniacae Amarum, Exocarpium Citri Rubrum 13 parts, alkyl polyglucoside 7 parts, Zinc Pyrithione 4 parts, hydroxypropyl methyl cellulose 7 parts, aminoacid protect Humectant 6 parts, dodecylbenzene sodium sulfonate 8 parts, lauroyl lysine 8 parts, emulsified silicone oil 5 parts, cocamido propyl betaine 2.5 Part, Kazon 1.9 parts, macadamia nut oil 4.6 parts, rosemary ethereal oil 3.2 parts, Jojoba oil 2.6 parts, deionized water 43 parts.

Preparation method and usage and dosage are with embodiment 1.

Embodiment 3: this effectively prevents the shampoo of pathologic alopecia, its active component is made up of the raw material of following weight (every part takes 25kg): collagen protein powder 13 parts, 12 parts of Rhizoma Zingiberis Recens, Radix Ginseng 4 parts, Bulbilus boussingaultiae pseudobaselloidis 10 parts, Cortex Dictamni 13 parts, Fructus Gleditsia 10 parts, Cacumen Platycladi 13 parts, Cortex Albiziae 11 parts, Semen Sesami Nigrum 13 parts, grass 9 parts, bamboo salt 7 parts, Flos Chrysanthemi Indici 15 parts, Rhizoma Polygonati Odorati 8 parts, Pericarpium Granati 9 Part, 8 parts of Semen Armeniacae Amarum, Exocarpium Citri Rubrum 11 parts, alkyl polyglucoside 5 parts, Zinc Pyrithione 2 parts, hydroxypropyl methyl cellulose 5 parts, aminoacid moisturizing Agent 4 parts, dodecylbenzene sodium sulfonate 6 parts, lauroyl lysine 6 parts, emulsified silicone oil 3 parts, cocamido propyl betaine 2.0 Part, Kazon 1.7 parts, macadamia nut oil 3.8 parts, rosemary ethereal oil 2.7 parts, Jojoba oil 2.1 parts, deionized water 38 parts.

Preparation method and usage and dosage are with embodiment 1.

Embodiment 4: this effectively prevents the shampoo of pathologic alopecia, its active component is made up of the raw material of following weight (every part takes 25kg): collagen protein powder 14 parts, 14 parts of Rhizoma Zingiberis Recens, Radix Ginseng 5 parts, Bulbilus boussingaultiae pseudobaselloidis 11 parts, Cortex Dictamni 14 parts, Fructus Gleditsia 12 parts, Cacumen Platycladi 14 parts, Cortex Albiziae 13 parts, Semen Sesami Nigrum 14 parts, grass 11 parts, bamboo salt 8 parts, Flos Chrysanthemi Indici 17 parts, Rhizoma Polygonati Odorati 10 parts, Pericarpium Granati 11 parts, 9 parts of Semen Armeniacae Amarum, Exocarpium Citri Rubrum 12 parts, alkyl polyglucoside 7 parts, Zinc Pyrithione 4 parts, hydroxypropyl methyl cellulose 6 parts, aminoacid protect Humectant 6 parts, dodecylbenzene sodium sulfonate 8 parts, lauroyl lysine 8 parts, emulsified silicone oil 5 parts, cocamido propyl betaine 2.2 Part, Kazon 1.8 parts, macadamia nut oil 4.2 parts, rosemary ethereal oil 2.9 parts, Jojoba oil 2.3 parts, deionized water 41 parts.

Preparation method and usage and dosage are with embodiment 1.

Embodiment 5: this effectively prevents the shampoo of pathologic alopecia, its active component is made up of the raw material of following weight (every part takes 25kg): collagen protein powder 14 parts, 13 parts of Rhizoma Zingiberis Recens, Radix Ginseng 5 parts, Bulbilus boussingaultiae pseudobaselloidis 11 parts, Cortex Dictamni 14 parts, Fructus Gleditsia 11 parts, Cacumen Platycladi 14 parts, Cortex Albiziae 12 parts, Semen Sesami Nigrum 14 parts, grass 10 parts, bamboo salt 8 parts, Flos Chrysanthemi Indici 16 parts, Rhizoma Polygonati Odorati 9 parts, Pericarpium Granati 10 Part, 9 parts of Semen Armeniacae Amarum, Exocarpium Citri Rubrum 12 parts, alkyl polyglucoside 6 parts, Zinc Pyrithione 3 parts, hydroxypropyl methyl cellulose 6 parts, aminoacid moisturizing Agent 5 parts, dodecylbenzene sodium sulfonate 7 parts, lauroyl lysine 7 parts, emulsified silicone oil 4 parts, cocamido propyl betaine 2.2 Part, Kazon 1.8 parts, macadamia nut oil 4.2 parts, rosemary ethereal oil 2.8 parts, Jojoba oil 2.2 parts, deionized water 39 parts.

Preparation method and usage and dosage are with embodiment 1.

Test example:

Effectively prevent the shampoo of pathologic alopecia for gained of the present invention, we have done stability test, safety respectively Property test and anticreep efficacy test.

Experiment 1: stability test

Effectively prevent from that the shampoo of pathologic alopecia is randomly drawed 60g sample respectively from embodiment 1-5 gained to carry out surely Qualitative experiment, is divided into three parts by the 60g that each embodiment is extracted, every part of 20g, is individually positioned in-3 DEG C, 40 DEG C, 60 DEG C Closed environment in carry out study on the stability, after placing 1 month, observe steadiness.Criterion: sample does not occur point Layer, variable color spoiled, obvious, low temperature can flow, then its study on the stability can be identified as passing through, and is exactly otherwise not pass through. Concrete condition is shown in Table 1:

Table 1: steadiness

Detection sample Embodiment 1 Embodiment 2 Embodiment 3 Embodiment 4 Embodiment 5 -3 DEG C of cold performances Pass through Pass through Pass through Pass through Pass through 40 DEG C of heat resistances Pass through Pass through Pass through Pass through Pass through 60 DEG C of heat resistances Pass through Pass through Pass through Pass through Pass through

Experimental result: either still stable the heat resistance of 40 DEG C and 60 DEG C the cold performance stability of-3 DEG C Property, embodiment of the present invention 1-5 gained effectively prevent the shampoo of pathologic alopecia the most do not occur layering, spoiled, obvious Metachromatism, low temperature can flow, so gained of the present invention effectively prevents the good stability of the shampoo of pathologic alopecia.

Experiment 2: safety testing

Effectively prevent from from gained of the present invention 60g sample randomly drawed respectively by the shampoo (embodiment 5) of pathologic alopecia Carry out safety experiment, carry out acute dermal toxicity test respectively and acute skin irritation is tested.

2.1, acute dermal toxicity test

Randomly selecting 50 healthy SPF levels to grow up kunming mice, weight (20 ± 2) g, male and female half and half are (big by Shandong Learn experimental animal center to provide).Test chamber temperature is 23-28 DEG C, relative humidity 50%-70%, well-ventilated, feeds with special Grain Mus feedstuff (feedstuff: provided by experimental animal center, Shandong Province).

Use according to the acute dermal toxicity test method in Ministry of Public Health " cosmetics health specification " (2007 editions) and once limit Mensuration, dosage is 2180mg/kg BW, and result of the test is shown in 2:

Table 2: tested material is to chmice acute percutaneous toxicity test situation

As can be seen from Table 2, smear gained of the present invention and effectively prevent the kunming mice after the shampoo of pathologic alopecia not The phenomena of mortality occur, and during the 7th day, the 14th day and the 21st day after smearing, the situation of weightening finish all occurs in body weight, so Can deduce gained of the present invention effectively prevents the shampoo of pathologic alopecia without acute dermal toxicity.

2.2 acute skin irritation tests

Randomly select 10 healthy New Zealand White rabbit, male and female half and half, body weight (2.4 ± 0.3) kg, Jinan match good fortune Laboratory animal cultivates company limited and provides.Rearing conditions: temperature 16-26 DEG C, humidity 40%-70%.

25cm is chosen in both sides, back every rabbit respectively2Square area, the phase at back on the left of every rabbit Answer region to smear gained of the present invention and effectively prevent the shampoo of pathologic alopecia, as experimental group, simultaneously on the right side of every rabbit The respective regions at back smears other shampoos (such as overlord's shampoo), as a control group, observe respectively skin erythema and Red and swollen situation, the results are shown in Table 3:

Table 3: tested material is to Rabbits with Acute skin irritation implementations

During observation, rabbit activity during testing is normal, and behavior is active, for there is uncomfortable rabbit, for seeing Seeing that feces is abnormal, mouth, nose, eye are without the pathological change such as secretions and dyspnea.Body weight is basically identical, has no significant effect.

Being obtained by table 3, when smearing 1h after other shampoos, there is slight erythema, skin irritation in some rabbit Mark reaches 0.6, and erythema or red and swollen phenomenon, skin irritation mark does not all occur in the rabbit smearing gained shampoo of the present invention It is 0;When smearing 24h after other shampoos, major part rabbit all occurs in that erythema in various degree or red and swollen phenomenon, skin irritation Property mark reached 1.7, and there is erythema or red and swollen phenomenon, skin in the part rabbit that also only has smearing gained shampoo of the present invention Zest mark is 0.6;And, during 72h after smearing the rabbit of gained shampoo of the present invention 48h after smearing and smearing All without erythema or red and swollen phenomenon, all rabbit recover normal, and that the rabbit smearing other shampoos has in various degree always is red Speckle or red and swollen phenomenon.

To sum up, from the point of view of security test result, gained of the present invention effectively prevents the toxicity of the shampoo of pathologic alopecia Almost 0, and much lower more than the toxicity of existing shampoo, can be inferred that gained of the present invention effectively prevents pathologic from taking off The shampoo sent out is the least to human body skin side effect, gentle safety, can relieved use.

Experiment 3: anticreep efficacy test

In order to verify that gained of the present invention effectively prevents the anticreep effect of the shampoo of pathologic alopecia, inventor was in 2013 March, in JIUYUE ,-2013 did contrast test, and the mode selecting human body directly to try out is tested.

Screening 120 volunteers, in 18-45 year, all there is an obvious alopecia phenomenon at the age, average every day alopecia 100-300 Root.Use single blind test form, 120 volunteers are randomly divided into experimental group and matched group two groups, wherein experimental group 100 People, matched group 20 people, 100 people in experimental group are randomly divided into 5 groups again, and each group 20 people, experimental group uses respectively Gained of the present invention effectively prevents the shampoo (embodiment 1-5) of pathologic alopecia, and matched group uses other shampoos (as overlord prevents De-shampoo), every day has one's hair wash once.

Any other cosmetics influential on result, medicine and health product are not used during test;Can be very well by test The requirement compatibility test of scheme, can keep regularity in one's life during studying.Follow up a case by regular visits to one by one after using 1 month, statistics Alopecia situation.

Statistical standard: " healing ": after using one month, alopecia phenomenon substantially reduces, average every day, alopecia was less than 50; " effective ": after using one month, alopecia phenomenon significantly reduces, average every day alopecia less than 100 or alopecia ratio reduces More than 50%;" effectively ": after using one month, alopecia phenomenon has certain alleviation, but alopecia ratio reduces less than 50%;" nothing Effect ": after using one month, without any alleviation, even there is the situation that alopecia is more serious in alopecia phenomenon.

Concrete condition is shown in Table 4:

Table 4: anticreep effect situation

Interpretation of result: can obtain from table 4, uses gained of the present invention effectively to prevent the cure rate of shampoo of pathologic alopecia equal Reach more than 55%, and use the cure rate of other anticreep shampoos to only reach 20%;Meanwhile, from the point of view of inefficiency, use this Invention gained effectively prevents the inefficiency majority of the shampoo of pathologic alopecia from having reached 0, and only part volunteer occurs in that nothing The situation of anticreep effect.Obviously, gained of the present invention effectively prevents the anticreep effect of the shampoo of pathologic alopecia more significantly, value Must promote the use of.

Finally it should be noted that embodiment is the optimum detailed description of the invention of the present invention, be not limited to this Invention, although being described in detail the present invention with reference to previous embodiment, for a person skilled in the art, it depends on So the technical scheme described in foregoing embodiments can be modified, or wherein portion of techniques feature is carried out equivalent replace Change.All within the spirit and principles in the present invention, any modification, equivalent substitution and improvement etc. made, should be included in the present invention Protection domain within.

Claims (3)

1. effectively prevent a shampoo for pathologic alopecia, it is characterized in that: its active component is by the raw material of following parts by weight Make: collagen protein powder 12-15 part, Rhizoma Zingiberis Recens 12-14 part, Radix Ginseng 3-6 part, Bulbilus boussingaultiae pseudobaselloidis 9-12 part, Cortex Dictamni 12-15 part, Fructus Gleditsia 9-13 part, Cacumen Platycladi 12-15 part, Cortex Albiziae 10-13 part, Semen Sesami Nigrum 12-15 part, grass 8-12 part, bamboo salt 6-9 part, Flos Chrysanthemi Indici 14-18 part, Rhizoma Polygonati Odorati 7-11 part, Pericarpium Granati 8-12 part, Semen Armeniacae Amarum 7-10 part, Exocarpium Citri Rubrum 10-13 part, alkyl polyglucoside 5-7 part, pyrithione Zinc 2-4 part, hydroxypropyl methyl cellulose 4-7 part, amino acid humectant 4-6 part, dodecylbenzene sodium sulfonate 6-8 part, lauroyl Lysine 6-8 part, emulsified silicone oil 3-5 part, cocamido propyl betaine 1.8-2.5 part, Kazon 1.6-1.9 part, macadamia nut oil 3.4-4.6 part, rosemary ethereal oil 2.4-3.2 part, Jojoba oil 1.8-2.6 part, deionized water 35-43 part.
The shampoo effectively preventing pathologic alopecia the most according to claim 1, is characterized in that: its active component is by following The raw material of parts by weight is made: collagen protein powder 14 parts, 13 parts of Rhizoma Zingiberis Recens, Radix Ginseng 5 parts, Bulbilus boussingaultiae pseudobaselloidis 11 parts, Cortex Dictamni 14 parts, Fructus Gleditsia 11 parts, Cacumen Platycladi 14 parts, Cortex Albiziae 12 parts, Semen Sesami Nigrum 14 parts, grass 10 parts, bamboo salt 8 parts, Flos Chrysanthemi Indici 16 parts, Rhizoma Polygonati Odorati 9 parts, stone Pomegranate skin 10 parts, 9 parts of Semen Armeniacae Amarum, Exocarpium Citri Rubrum 12 parts, alkyl polyglucoside 6 parts, Zinc Pyrithione 3 parts, hydroxypropyl methyl cellulose 6 parts, amino Acid wetting agent 5 parts, dodecylbenzene sodium sulfonate 7 parts, lauroyl lysine 7 parts, emulsified silicone oil 4 parts, cocamidopropyl propyl amide Radix Betae 2.2 parts of alkali, Kazon 1.8 parts, macadamia nut oil 4.2 parts, rosemary ethereal oil 2.8 parts, Jojoba oil 2.2 parts, deionized water 39 parts.
3., according to the preparation method of the arbitrary described shampoo effectively preventing pathologic alopecia of claim 1-2, it is characterized in that, Comprise the steps:
(1) Bulbilus boussingaultiae pseudobaselloidis and Fructus Gleditsia are placed in glass container, add 4-6 times of Bulbilus boussingaultiae pseudobaselloidis and 28-32 ° of rice wine of Fructus Gleditsia quality sum, Place 2-4 days at a temperature of 35-45 DEG C, filter, obtain the Bulbilus boussingaultiae pseudobaselloidis after moistening and Fructus Gleditsia;By the Bulbilus boussingaultiae pseudobaselloidis after moistening and Fructus Gleditsia Being placed in non iron frying pan, add Semen Sesami Nigrum and Semen Armeniacae Amarum, moderate heat stir-fries 30-40 minute, dries, and pulverizes, and crosses 100-140 mesh sieve;
(2) Cortex Dictamni, Cacumen Platycladi, grass, Rhizoma Polygonati Odorati and Exocarpium Citri Rubrum are placed in frying pan, add 2-4 times of Cortex Dictamni, Cacumen Platycladi, grass, Rhizoma Polygonati Odorati and the Testa Tritici of Exocarpium Citri Rubrum quality sum, moderate heat stir-fries 30-40 minute, takes out, cools, and sieve removes Testa Tritici, the Cortex Dictamni that must process, Cacumen Platycladi, grass, Rhizoma Polygonati Odorati and Exocarpium Citri Rubrum;
(3) Rhizoma Zingiberis Recens is pounded Rhizoma Zingiberis Recens mud, is placed in squeezer, add macadamia nut oil, under the rotating speed of 75-85 rev/min, squeeze extracting juice, Obtain the first Sucus Zingberis;In squeezer, add the pure water of 2-4 times of Rhizoma Zingiberis Recens dregs quality, again carry out under the rotating speed of 75-85 rev/min Squeezing, obtains the second Sucus Zingberis, merges the first Sucus Zingberis and the second Sucus Zingberis, and when being concentrated into 55 DEG C-65 DEG C, relative density is 1.12-1.16's Rhizoma Zingiberis Recens cream, gained Rhizoma Zingiberis Recens cream and Rhizoma Zingiberis Recens dregs are standby;
(4) step (3) gained Rhizoma Zingiberis Recens dregs is placed in glass container, adds the rice vinegar of 4-6 times of Rhizoma Zingiberis Recens dregs quality, mix thoroughly, at 2 DEG C-6 DEG C Lower seal cold preservation 3-5 hour, is placed in the Rhizoma Zingiberis Recens dregs after cold preservation in Chinese medicine extracting tank, adds Radix Ginseng, Cortex Albiziae, Flos Chrysanthemi Indici and Punica granatum L. Skin, adds 7-10 times of Radix Ginseng, Cortex Albiziae, Flos Chrysanthemi Indici and the water of Pericarpium Granati quality sum, extracts 40-50 minute, obtain filtering residue and extraction Liquid A;
(5) step (4) gained filtering residue is again placed in the Chinese medicine extracting tank that step (4) uses, adds step (2) gained and process Cortex Dictamni, Cacumen Platycladi, grass, Rhizoma Polygonati Odorati and the Exocarpium Citri Rubrum crossed, adds 4-7 times of Cortex Dictamni, Cacumen Platycladi, grass, Rhizoma Polygonati Odorati and Exocarpium Citri Rubrum quality The water of sum, extracts twice, extracts 45-55 minute, united extraction liquid every time, mixes with the extracting solution A of step (4) gained, stands 3-5 hour, filter, obtain medicinal liquid;Collagen protein powder, amino acid humectant and Kazon, mix homogeneously is added in gained medicinal liquid;
(6) bamboo salt is pulverized, be placed in dissolving tank, add deionized water, stir and be completely dissolved to bamboo salt, add hydroxypropyl methyl Cellulose, dodecylbenzene sodium sulfonate, lauroyl lysine and step (1) gained sieve after powder, the most slowly add Heat to temperature is 60-70 DEG C, and isothermal holding, after 2-3 hour, is cooled to when 24-28 DEG C add alkyl polyglucoside, Zinc Pyrithione, coconut palm Oleamide CAB and step (3) gained Rhizoma Zingiberis Recens cream, mix homogeneously, isothermal holding 2-4 hour;
(7) by step (5) products therefrom and step (6) products therefrom mix homogeneously, add emulsified silicone oil, be slowly stirred clockwise 20-30 minute, at 38 DEG C-43 DEG C, it is concentrated into the thick liquid that relative density is 1.15-1.25, adds rosemary ethereal oil and He He Bar oil, stirs, and sterilizes 20-30 minute at 130-150 DEG C, and addition sodium citrate is until pH value is 5.8-6.3, and stirring is all Even, encapsulation, obtain the described shampoo effectively preventing pathologic alopecia.
CN201610874686.6A 2016-09-30 2016-09-30 A kind of shampoo effectively preventing pathologic alopecia and preparation method thereof CN106265370A (en)

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Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107034051A (en) * 2017-05-08 2017-08-11 北京联合大学 One kind is containing amygdalate hair soap and preparation method thereof
CN107034050A (en) * 2017-05-08 2017-08-11 北京联合大学 One kind contains gleditsia sinensis and the two-in-one hair soap of semen armeniacae amarae and preparation method thereof
CN107157894A (en) * 2017-06-13 2017-09-15 张挺 A kind of Chinese medicine shampoo containing ginger
CN107412108A (en) * 2017-09-01 2017-12-01 安庆徽云博冠化妆品科技有限公司 A kind of Anti-hair loss shampoo and preparation method thereof
CN108261369A (en) * 2018-02-09 2018-07-10 广州御延堂生物科技有限公司 A kind of composite plant shampoo and preparation method thereof
CN108354877A (en) * 2018-03-30 2018-08-03 四川自然菲科技有限公司 A kind of shampoo prescription and preparation method thereof containing mixing nut component

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104814884A (en) * 2015-04-21 2015-08-05 山东福瑞达生物科技有限公司 Liquid shampoo capable of preventing hair loss and promoting hair growth and preparation method thereof
CN105214022A (en) * 2014-07-06 2016-01-06 辛海峰 A kind of Traditional Chinese drug mixture of hair growth

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105214022A (en) * 2014-07-06 2016-01-06 辛海峰 A kind of Traditional Chinese drug mixture of hair growth
CN104814884A (en) * 2015-04-21 2015-08-05 山东福瑞达生物科技有限公司 Liquid shampoo capable of preventing hair loss and promoting hair growth and preparation method thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
(韩)金昭亨: "《韩医皮肤专家金昭亨教你打造韩式肌肤》", 31 January 2010, 中国轻工业出版社 *

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107034051A (en) * 2017-05-08 2017-08-11 北京联合大学 One kind is containing amygdalate hair soap and preparation method thereof
CN107034050A (en) * 2017-05-08 2017-08-11 北京联合大学 One kind contains gleditsia sinensis and the two-in-one hair soap of semen armeniacae amarae and preparation method thereof
CN107034050B (en) * 2017-05-08 2019-11-15 北京联合大学 One kind containing gleditsia sinensis and the two-in-one hair soap of semen armeniacae amarae and preparation method thereof
CN107034051B (en) * 2017-05-08 2019-11-15 北京联合大学 One kind is containing amygdalate hair soap and preparation method thereof
CN107157894A (en) * 2017-06-13 2017-09-15 张挺 A kind of Chinese medicine shampoo containing ginger
CN107412108A (en) * 2017-09-01 2017-12-01 安庆徽云博冠化妆品科技有限公司 A kind of Anti-hair loss shampoo and preparation method thereof
CN108261369A (en) * 2018-02-09 2018-07-10 广州御延堂生物科技有限公司 A kind of composite plant shampoo and preparation method thereof
CN108354877A (en) * 2018-03-30 2018-08-03 四川自然菲科技有限公司 A kind of shampoo prescription and preparation method thereof containing mixing nut component

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