CN102188359A - Application of leech to nursing of hair or scalp of head, composition and preparation method - Google Patents
Application of leech to nursing of hair or scalp of head, composition and preparation method Download PDFInfo
- Publication number
- CN102188359A CN102188359A CN 201110106890 CN201110106890A CN102188359A CN 102188359 A CN102188359 A CN 102188359A CN 201110106890 CN201110106890 CN 201110106890 CN 201110106890 A CN201110106890 A CN 201110106890A CN 102188359 A CN102188359 A CN 102188359A
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- China
- Prior art keywords
- hair
- scalp
- head
- hirudo
- nurse
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 210000003128 head Anatomy 0.000 title claims abstract description 37
- 210000004761 scalp Anatomy 0.000 title claims abstract description 30
- 238000002360 preparation method Methods 0.000 title claims abstract description 20
- 239000000203 mixture Substances 0.000 title claims abstract description 15
- 230000000474 nursing effect Effects 0.000 title abstract description 7
- 241000545744 Hirudinea Species 0.000 title abstract description 6
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- 108010007267 Hirudins Proteins 0.000 claims abstract description 27
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- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 235000018102 proteins Nutrition 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 210000003296 saliva Anatomy 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 229920002545 silicone oil Polymers 0.000 description 1
- 230000009759 skin aging Effects 0.000 description 1
- 230000037394 skin elasticity Effects 0.000 description 1
- 238000002791 soaking Methods 0.000 description 1
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 1
- 235000019832 sodium triphosphate Nutrition 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 239000003868 thrombin inhibitor Substances 0.000 description 1
- 230000008736 traumatic injury Effects 0.000 description 1
- XPFJYKARVSSRHE-UHFFFAOYSA-K trisodium;2-hydroxypropane-1,2,3-tricarboxylate;2-hydroxypropane-1,2,3-tricarboxylic acid Chemical compound [Na+].[Na+].[Na+].OC(=O)CC(O)(C(O)=O)CC(O)=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O XPFJYKARVSSRHE-UHFFFAOYSA-K 0.000 description 1
- 229940099259 vaseline Drugs 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
Abstract
The invention belongs to the field of cosmetics and relates to novel application of leech, i.e. application of the leech to nursing of hair or scalp of a head, a composition which is prepared by using the leech as the main raw material and is used for nursing the hair or the scalp of the head, and a preparation method of the composition. For the novel application of the leech, the effects of hirudin on activating blood, dissolving stasis, promoting blood circulation and removing obstruction in channels are utilized for nursing the hair or the scalp of the head, so that blood circulation of the head is strengthened, the blood flow is enhanced, the scalp is nourished, capillary waste of the scalp is removed, melanin is timely conveyed for hair papilla and the hair is blackened and brightened. A research process also shows that the hirudin has capabilities of promoting the metabolism of the scalp, activating hair follicle tissues and strengthening hair roots so as to achieve the effects on hair promotion, hair nourishment and alopecia prevention, fundamentally improve the physiological status of the hair, promote the hair growth and integrate three effects on alopecia prevention, alopecia treatment and hair growth into a whole; and the hirudin also has an effect of repairing damaged hair, so that the hair becomes smooth and tenacious.
Description
Technical field
The invention belongs to cosmetic field, the new application Hirudo that relates to Hirudo is used to nurse the purposes of head hair or scalp, and is primary raw material with the Hirudo, is used to nurse the compositions and the preparation method of head hair or scalp.
Background technology
Hirudo is a Chinese medicine simply, and history is stated from Shennong's Herbal, and the successive dynasties book on Chinese herbal medicine all has record.The traditional Chinese medical science thinks that it has the function of removing blood stasis, eliminating blood stasis and inducing menstruation, always is used for the treatment of lump in the abdomen, mass in the abdomen, blood stasis amenorrhea, traumatic injury.Chinese Pharmacopoeia version in 2000 is recorded the dry body into Hirudinidae animal whitmania WhitmanpigraWhitman, Hirudo HinudenipponicaWhitman or Folium Salicis Babylonicae Hirudo WhitmaniaacranulataWhitman.In the Hirudo there be main component: 1, directly act on the composition of blood coagulation system, comprise thrombin inhibitor, and the material of other inhibition blood coagulation, as hirudin (Hirudin), Hirudinaria manillensis element (Bufrudin), forest mountain trematodiasis element (Haemadin) etc.2, other protease inhibitor and other active component are as Cellosolve (Hementerin), treating can gloomy (Decorsin) etc.3, other compositions: the Hirudo master contains protein, contain 17 seed amino acids in addition, comprise 8 seed amino acids of needed by human, also contain 14 kinds of elements such as Zn, Mn, Fe, Co, Cr, Se, Mo, Ni, kiss nutritional labelings such as trematodiasis element, heparin, antithrombotic element, aminoacid ingredient in addition.
At present, use extract or its main component hirudin of Hirudo in the existing more cosmetics.Extract as Hirudo can be used for speckle dispelling, anti-acne, skin moistening, skin care, whitens, prevents skin aging, strengthens the effect of skin elasticity.
Dense, pitch-black, bright hair and attractive in appearance, generous, clean and tidy hair style can not only set off the people radiantly, beautiful colourful, and are healthy signs, and therefore, of all times, men and women, old and young nearly all pay much attention to the protection and the modification of hair.Protection and modification hair except needs are are often washed and dressed, kept clean, also need scientifically to use some hair care articles.People's hair condition is subjected to the influence of inherited genetic factors, but daily nursing is improper and the various diseases of hair also can cause hair injury or hair is withered, bifurcated, come off, thereby can influence people's looks and spirit to some extent.What notice when common people take care of hair is the maintenance of hair quality, but most people have ignored the maintenance of scalp.If the care of incorrect skin has add, consequence is well-known---alopecia, fat secretion are vigorous, dandruff problem, pruritus, allergy etc. all take place easily.If hair follicle sustains damage, be in " false death " state, then can not be from scalp from absorbing nutrient substance, ball top cell notice increases, the beginning atrophy, hair will attenuate, flavescence, change are withered.After hair follicle degeneration and atrophy, hair will stop growing, and withered gradually coming off.Shang Weijian uses report and the application of Hirudo in head hair, scalp care separately, more do not see Hirudo is applied to educate send out, hair care, anticreep, make the hair blackening brighten, submissive tough.
Summary of the invention
Technical problem solved by the invention provides the new purposes of a kind of Hirudo, is used to nurse head hair or scalp.
New purposes of the present invention mainly is to utilize hirudin to have blood circulation promoting and blood stasis dispelling, and the effect of promoting blood circulation to remove obstruction in the collateral strengthens the head blood circulation, strengthens blood flow, nourishes scalp, clears away scalp blood capillary rubbish, in time carries melanin for hair papilla, makes the hair blackening brighten.Research process finds that also hirudin can promote the scalp metabolism, and activation hair follicle tissue strengthens root of hair, thus reach educate send out, the effect of hair care, anticreep, improve scalp ecology, promote hair growth from root, with anticreep, anti-avulsion, the unification of hair growth promoting triple effect.Hirudin can also be repaired impaired hair quality, makes healthy hair become submissive tough.
Utilize the new purposes of Hirudo, can be made into the head care product.The head care product specifically can be divided into free wool hair cosmetic and hair care and apply some make up, and product form has the fragrant quilt of liquid hair washing, paste shampoo, hair washing gel, hair conditioner (comprise and washing and disposable two kinds), suppurative mastitis, hair lotion, hair oil, hairdressing gel, sends out film, pomade etc.Also can add suitable adjuvant according to the needs of dosage form separately.
The present invention utilize Hirudo make the hair blackening brighten, submissive tough, realize educating send out, the function of hair care, anticreep, for the public provides a kind of brand-new selection.
The specific embodiment
The present invention utilizes hirudin to have blood circulation promoting and blood stasis dispelling, the effect of promoting blood circulation to remove obstruction in the collateral, make the hair blackening brighten, submissive tough, realize educating send out, the effect of hair care, anticreep.
One, determining of active component dose-effect relationship of the present invention:
Hirudo extract, natural hirudin and lepirudin 023 ludon solution in different concentration are used separately, and everyone respectively uses weekly 2～3 times, use one month continuously after, according to the valid density of active component in the effect screening product.
Hirudo extract of the present invention, natural hirudin and lepirudin 023 ludon are respectively:
1, the conventional preparation method of Hirudo extract is: get all rubbing of fresh Hirudo and make the Hirudo slurry, proportioning by volume: 1 part in Hirudo slurry: the batching of 0.01～0.1 part of concentrated hydrochloric acid, 1～10 part in acetone is extracted; get acetone solution; residue reuse acetone extraction; filter; merge acetone extract, dry getting final product.
2, the natural hirudin extraction process is: get fresh Hirudo saliva, add acetone, and cooling, it is centrifugal to get supernatant, and residue adds the trichloroacetic acid dissolving, column chromatography in the sampling:
(1) anion exchange chromatography: get an amount of DEAE-C52 adding distil water and make its expansion, be washed with distilled water to neutrality after respectively soaking 30min with NaOH-NaCl mixed liquor, dilute hydrochloric acid solution and NaOH-NaCl mixed liquor successively according to a conventional method, behind the dress post, citric acid-sodium citrate buffer balance with pH4.6, sample carries out gradient elution and draws elution curve with monitor on the above-mentioned trichloroacetic acid solution, the Fractional Collections eluent, to have vigor partly to concentrate in the bag filter concentrates with glycerol, the two vena contracta methods of reuse are surveyed total protein content, continue following column chromatography;
(2) gel filtration chromatography is got an amount of Sephadex-G25 adding distil water immersion 4h, uses NaOH-NaCl mixed liquid dipping 0.5h according to a conventional method, and sucking filtration is removed alkali liquor and is washed with distilled water to neutrality, and heated and boiled is removed bubble.The dress post with the buffer balance of pH7.4, is drawn elution curve with sample on the above-mentioned concentrated solution that the vigor eluent arranged, eluting and with monitor, and Fractional Collections has the vigor eluent; Reclaim solvent, get final product after the drying.
Or directly buy the commercially available prod.
3, (patent No.: 01105798.X), the 32nd to 35 of its molecule and the 53rd to 66 amino acids sequence are lepirudin 023 ludon: Arg32-Gly33-Asp34-Ser35; Gln53-Gly54-Asp55-Phe56-Glu57-Pro58-Ile59-Pro60-Glu61-As p62-Ala63-Tyr64-Asp65-Glu66.
Test result sees Table 1:
The no positive effect of (-) expression
(+) expression produces effect
(++) expression has positive effect
(+++) expression has very positive effect
Table 1 active component dose-effect relationship
The above table explanation, adopt the difference on effect of the Hirudo medicine of variable concentrations to be: when concentration was lower than 5%, hair growth promoting amount and toughness had no significant change in the shiny black degree of hair, the hair follicle; When concentration is 5% when above, it is more shiny black that hair becomes, and the hair growth promoting amount also obviously increases in the hair follicle, and simultaneously, the hair toughness is strengthened; But when concentration is increased to 15% when above, head pruritus, phenomenon that dandruff is many can appear in tester's reflection.To sum up experimental result is finally selected 5-15% (%, concentration range g/g).
Two, the preparation of hair conditioning of the present invention and scalp product:
Utilize Hirudo to can be used for nursing the new purposes of head hair or scalp, can be made into the fragrant quilt of liquid hair washing, paste shampoo, hair washing gel, hair conditioner, hair conditioner (disposable), suppurative mastitis, hair lotion, hair oil, hairdressing gel, send out head care products such as film, pomade, the percentage by weight that Hirudo extract or natural hirudin or lepirudin 023 ludon account for outer head care product is 5-15%.
Preparation head care product, it mainly consists of following percentage by weight:
The effect of above-mentioned surfactant mainly is to promote Hirudo extract, natural hirudin or lepirudin 023 ludon and water, additive etc. to dissolve each other.Adoptable surfactant has: aliphatic alcohol sulfate; fatty alcohol polyoxyethylene ether sulfate; glycerine monofatty ester sulfate; alcohol ether sulfosuccinic acid monoesters disodium salt; sulphosuccinates; the fatty acyl sodium glutamate; Oleum Cocois single ethanol amide 2-Sulfosuccinic acid monoester disodium salt; alkenyl sulphonate; the N-acyl glutamate; the alkyl phosphoric acid esters; dodecyldimethylammonium hydroxide inner salt; the imidazoline type betanin; amine oxide; N-alkyl aminopropionic acid salt; alkylolamides; ethylene oxide condensate etc.
Additive is for preparation head nursing materials typical additives, as conditioner, thickening agent, dandruff removing agent, moisturizing agent, opacifier, clarifier, acidulant, chelating agen, antiseptic, pigment etc.
The preparation example is as follows:
Embodiment 1: Hirudo extract shampoo body note ripple prescription and preparation method thereof
Method for making: AES is slowly added in 70 ℃ of hot water, K12 also is dissolved in the hot water under stirring, after treating all dissolvings, add lauric acid diethyl amide, after treating to dissolve fully, be cooled to 45 ℃ and add hirudin extract, EDTA, antiseptic, essence etc. again, add purified water at last to capacity, with the required scope of pH value of citric acid adjustment shampoo, reuse sodium chloride is adjusted the viscosity of shampoo.
Embodiment 2: the prescription and the preparation method of natural hirudin shampoo body note ripple:
Method for making: lauryl alcohol ammonium sulfate is dissolved in 70 ℃ of hot water, lauramide diethanolamine, imidazolinium betaine, alcohol ether sulfosuccinic acid monoesters disodium salt, DOE-120, emulsified silicone oil are adorned with another container, be dissolved in the hot water, after fully miscible, again with lauryl alcohol ammonium sulfate stirring and evenly mixing, to be cooled to 45 ℃, add natural hirudin, Pearl Concentrate and antiseptic, essence etc., mix.Add purified water at last to capacity, adjust pH value with an amount of citric acid, reuse sodium chloride is adjusted the viscosity of shampoo, promptly.
Embodiment 3: natural hirudin hair cream prescription and preparation method thereof
Method for making: sodium lauryl sulphate, NaOH are added in the entry, be heated to 90 ℃, stirring makes its dissolving evenly, add again and dissolve good stearic acid, lanolin mixture, stir, add sodium tripolyphosphate, glycerol, antiseptic, pigment etc. then successively and stir, adding natural hirudin, essence stir evenly and get final product when being cooled to 45 ℃.
Embodiment 4: lepirudin 023 ludon hair washing gel prescription and preparation method thereof
Method for making: under the strong agitation, Carbopol980 slowly is scattered in the water about 20 ℃, stirs, form the aqueous solution of concentration about 30%; Other gets other component mix homogeneously, adds to the formation gel that neutralizes in the Carbopol980 dispersion liquid, promptly gets (note, behind the formation gel, can not carry out vigorous stirring again, otherwise can make the gel viscosity degradation).
Embodiment 5: Hirudo extract hair conditioner prescription and preparation method:
Method for making: polyoxyethylene (20) anhydrous sorbitol, glycerol, polyvinyl alcohol, polyoxyethylene (20) anhydrous sorbitol, monostearate are mixed and heated to 90 ℃ (components 1), with the hexadecanol heat fused, in the time of 75 ℃, component 1 is mixed with Hirudo extract, add in the hexadecanol, stirring and emulsifying adds essence, pigment, antiseptic etc. when being cooled to 45 ℃, stir to be cooled to room temperature and to get final product.
Embodiment 6: natural hirudin hair oil prescription and preparation method:
Method for making: at normal temperatures with whole oil phase component mixed dissolutions, heat up, stir simultaneously, slowly add natural hirudin, tween 80 when being heated to 40～60 ℃, stir and make its abundant mix homogeneously, add essence, antioxidant, pigment etc. again, it is Clear ﹠ Transparent to hair oil to stir, cool off, filter, leave standstill, fill, promptly.
Embodiment 7: lepirudin 023 ludon suppurative mastitis prescription and preparation method:
Method for making: C16～C18 mixed alcohol, vaseline, acetylated lanolin, white oil, glyceryl monostearate are heated to 70～75 ℃ (components 1); Glycerol, octodecyl alcohol polyoxyethylene (25) ether, Tween-60 be the device splendid attire in addition, is heated to 70～75 ℃ (components 2); Behind component 2 and lepirudin 023 ludon mixing, add component 1 homogenizing stirring and emulsifying slowly, add essence, antiseptic when continuing to be stirred to 45 ℃, be cooled to below 40 ℃, fill, promptly.
Embodiment 8: leech Ti Qu Wu hairdressing gel prescription and preparation method:
Method for making: oil phase component oleyl alcohol, glyceryl monostearate, Fructus Maydis oil, dimethyl-silicon wet goods are mixed and heated to 70～75 ℃, make its fusion, in addition with glycerol, Hirudo extract, tween 20 and water and antiseptic Hybrid Heating to 70～75 ℃, making becomes homogeneous solution, and under agitation it is added in the oil phase, emulsifying adds silk peptide albumen and essence, pigment when being cooled to 40 ℃, be cooled to room temperature again, promptly.
Three, the compliance test result of product of the present invention:
Application Example 1: hair growth promoting experiment
Rat divide at random hirudin extract liquid shampoo (press embodiment 1 preparation) little, in, heavy dose of group, 4 groups of common shampoo groups, hirudin extract liquid shampoo is little, in, heavy dose presses respectively 1g/ time, 2g/ time, 4g/ time; Common shampoo is pressed 2g/ use.Each treated animal is in advance prior to back same area cropping, and the cropping area is 3 * 3cm, brings into use the same day in cropping, and use once every day, and continuous 7 days, cut newborn hair at cropping position last time on the 8th day, the electronic balance precision is weighed.The results are shown in Table 2:
Table 2 Hirudo extract liquid shampoo to the rat cropping after the influence of hair growth
| Group | Mus number (only) | Dosage (g/ time) | Newborn gross weight amount (mg) |
| Hirudo extract liquid shampoo | 5 | 1 | 65.8±8.67 |
| Hirudo extract liquid shampoo | 5 | 2 | 76.41±14.38* |
| Hirudo extract liquid shampoo | 5 | 4 | 89.25±12.40** |
| Common shampoo | 5 | 2 | 54.2±9.01 |
Compare with common shampoo group
*P＜0.05,
*P＜0.01.
The result shows that Hirudo extract liquid shampoo can obviously promote cropping rat hair growth, and newborn gross weight amount is apparently higher than common shampoo group.
Application Example 2: mass method is measured hair moisture
The tester is divided into 5 groups at random, is respectively common shampoo and cooperates common hair conditioner group, and embodiment 1～4 product cooperation embodiment 5 hair conditioner groups, everyone respectively uses weekly 2～3 times, and consumption is with used hair washing product is consistent at ordinary times.Use after one month continuously, cut a small amount of hair of tester and measure hair moisture, the results are shown in Table 3:
The determination of moisture of table 3 hair
| Group | Tester's (individual) | Dosage (g/ time) | Hair moisture (%) |
| Common shampoo cooperates common hair conditioner group | 3 | 10+5 | 16.76 |
| Embodiment 1 product cooperates embodiment 5 hair conditioner groups | 3 | 10+5 | 25.12 |
| Embodiment 2 products cooperate embodiment 5 hair conditioner groups | 3 | 10+5 | 26.45 |
| Embodiment 3 products cooperate embodiment 5 hair conditioner groups | 3 | 10+5 | 28.02 |
| Embodiment 4 products cooperate embodiment 5 hair conditioner groups | 3 | 10+5 | 25.65 |
The result shows that embodiment 1～4 product cooperates embodiment 5 hair conditioner can obviously increase the hair water content, and the hair water content is protected group of products apparently higher than common washing.
Application Example 3: sensory testing
The tester is divided into 5 groups at random, is respectively common shampoo and cooperates common hair conditioner group, and embodiment 1～4 product cooperation embodiment 5 hair conditioner groups, everyone respectively uses weekly 2～3 times, and consumption is with used hair washing product is consistent at ordinary times.Use after one month continuously, assessed by tester's sensory evaluation scores system by the Specialty Experiment personnel, full marks are in 5 minutes, and 5 to be divided into effect best, the easy combing of hair, submissive, good hand touch, to weaken be 4 minutes to effect successively, 3 minutes, and 2 minutes, 1 minute, effect was the poorest in 1 minute, and it is serious to tangle during combing, hair coarse, dry and astringent.The results are shown in Table 4:
Table 4 sensory testing
| Group | Tester's (individual) | Dosage (g/ time) | Sensory evaluation scores |
| Common shampoo cooperates common hair conditioner group | 3 | 10+5 | 3.5 |
| Embodiment 1 product cooperates embodiment 5 hair conditioner groups | 3 | 10+5 | 4.5 |
| Embodiment 2 products cooperate embodiment 5 hair conditioner groups | 3 | 10+5 | 5 |
| Embodiment 3 products cooperate embodiment 5 hair conditioner groups | 3 | 10+5 | 5 |
| Embodiment 4 products cooperate embodiment 5 hair conditioner groups | 3 | 10+5 | 5 |
The result shows that embodiment 1～4 product cooperates the easy combing of embodiment 5 hair conditioner hairs, submissive, good hand touch, and the submissive degree of hair is protected group of products apparently higher than common washing.
To sum up, the present invention utilize Hirudo make the hair blackening brighten, submissive tough, realize educating send out, the function of hair care, anticreep, for the public provides a kind of brand-new selection.
Claims (10)
1. Hirudo is used to nurse the application of head hair or scalp, it is characterized in that: the extract or natural hirudin or the lepirudin 023 ludon that adopt Hirudo.
2. Hirudo according to claim 1 is used to nurse the application of head hair or scalp, it is characterized in that: extract of employing Hirudo or natural hirudin or lepirudin 023 ludon are active component, add conventional adjuvant and make the head care product.
3. Hirudo according to claim 2 is used to nurse the application of head hair or scalp, it is characterized in that: described head care product is that free wool hair cosmetic and hair care apply some make up.
4. Hirudo according to claim 2 is used to nurse the application of head hair or scalp, it is characterized in that: described head care product is liquid shampoo, paste shampoo, hair washing gel, hair conditioner, suppurative mastitis, hair lotion, hair oil, hairdressing gel, sends out film or pomade.
5. Hirudo according to claim 2 is used to nurse the application of head hair or scalp, it is characterized in that: to account for the percentage by weight of outer head care product be 5-15% to active component in the described head care product;
When described head care product was the free wool hair cosmetic, the percentage by weight that active component accounts for outer free wool hair cosmetic was 5-15%;
When described head care product applied some make up for the cleaning hair care, it was 5-15% that active component accounts for the outer percentage by weight that applies some make up of taking care of hair.
6. Hirudo according to claim 2 is used to nurse the application of head hair or scalp, it is characterized in that: described head care product is made up of the component of following weight percentage ratio:
7. be used to nurse the compositions of head hair or scalp, it is characterized in that: the component by following weight percentage ratio is formed:
8. the compositions that is used to nurse head hair or scalp according to claim 7 is characterized in that:
Described additive is a kind of or its combination in any in conditioner, thickening agent, dandruff removing agent, moisturizing agent, opacifier, clarifier, acidulant, chelating agen, antiseptic, the pigment;
Described surfactant is an aliphatic alcohol sulfate; fatty alcohol polyoxyethylene ether sulfate; glycerine monofatty ester sulfate; alcohol ether sulfosuccinic acid monoesters disodium salt; sulphosuccinates; the fatty acyl sodium glutamate; Oleum Cocois single ethanol amide 2-Sulfosuccinic acid monoester disodium salt; alkenyl sulphonate; the N-acyl glutamate; the alkyl phosphoric acid esters; dodecyldimethylammonium hydroxide inner salt; the imidazoline type betanin; amine oxide; N-alkyl aminopropionic acid salt; alkylolamides; a kind of or its any mixing in the ethylene oxide condensate.
9. be used to nurse the preparation of compositions method of head hair or scalp, it is characterized in that: extract of employing Hirudo or natural hirudin or lepirudin 023 ludon are active component, add conventional adjuvant, are prepared from according to conventional method;
Wherein, the percentage by weight of active component and adjuvant is as follows:
10. the preparation of compositions method that is used to nurse head hair or scalp according to claim 9 is characterized in that: described additive is a kind of or its combination in any in conditioner, thickening agent, dandruff removing agent, moisturizing agent, opacifier, clarifier, acidulant, chelating agen, antiseptic, the pigment; Described surfactant is an aliphatic alcohol sulfate; fatty alcohol polyoxyethylene ether sulfate; glycerine monofatty ester sulfate; alcohol ether sulfosuccinic acid monoesters disodium salt; sulphosuccinates; the fatty acyl sodium glutamate; Oleum Cocois single ethanol amide 2-Sulfosuccinic acid monoester disodium salt; alkenyl sulphonate; the N-acyl glutamate; the alkyl phosphoric acid esters; dodecyldimethylammonium hydroxide inner salt; the imidazoline type betanin; amine oxide; N-alkyl aminopropionic acid salt; alkylolamides; a kind of or its any mixing in the ethylene oxide condensate.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108186484A (en) * | 2018-02-05 | 2018-06-22 | 潘康奕 | A kind of Haircare composition and preparation method containing rice washing water and its extract, application |
| CN108743426A (en) * | 2018-07-25 | 2018-11-06 | 宁波博睿修存生物科技有限公司 | Maintenance lotion |
| CN110604746A (en) * | 2019-10-25 | 2019-12-24 | 云南三相科技有限公司 | Method for preparing hair-nourishing product from active extract of Poecilobdella manillensis lyophilized powder |
| CN111957228A (en) * | 2020-08-11 | 2020-11-20 | 广州碧涛化妆品有限公司 | Emulsifying device and preparation method of pomade |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1522689A (en) * | 2003-09-12 | 2004-08-25 | 周维海 | Leech extract cosmetics and method for making same |
| CN1732897A (en) * | 2005-08-16 | 2006-02-15 | 周维海 | Face-beautifying skin-caring lotion with leech extract and its preparation process |
-
2011
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1522689A (en) * | 2003-09-12 | 2004-08-25 | 周维海 | Leech extract cosmetics and method for making same |
| CN1732897A (en) * | 2005-08-16 | 2006-02-15 | 周维海 | Face-beautifying skin-caring lotion with leech extract and its preparation process |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108186484A (en) * | 2018-02-05 | 2018-06-22 | 潘康奕 | A kind of Haircare composition and preparation method containing rice washing water and its extract, application |
| CN108743426A (en) * | 2018-07-25 | 2018-11-06 | 宁波博睿修存生物科技有限公司 | Maintenance lotion |
| CN110604746A (en) * | 2019-10-25 | 2019-12-24 | 云南三相科技有限公司 | Method for preparing hair-nourishing product from active extract of Poecilobdella manillensis lyophilized powder |
| CN111957228A (en) * | 2020-08-11 | 2020-11-20 | 广州碧涛化妆品有限公司 | Emulsifying device and preparation method of pomade |
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