CN102188331B - Hair or head skin cosmetics composite - Google Patents

Hair or head skin cosmetics composite Download PDF

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Publication number
CN102188331B
CN102188331B CN201010122699.0A CN201010122699A CN102188331B CN 102188331 B CN102188331 B CN 102188331B CN 201010122699 A CN201010122699 A CN 201010122699A CN 102188331 B CN102188331 B CN 102188331B
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hair
weight
cosmetic composition
present
pantothenylol
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CN102188331A (en
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李起贤
姜秉夏
朴元锡
闵大珍
韩芝淑
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Amorepacific Corp
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Amorepacific Corp
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Abstract

The present invention relates to a kind of compositions improving hair or scalp state, especially will be selected from i) Zinc Pyrithione;Ii) pantothenylol;And iii) salicylic acid, nicotiamide and Cacumen Platycladi core extract more than one materials as effective ingredient, thus obtain there is Anti-hair loss and promote hair or the head skin cosmetics composite of hair growth effect.

Description

Hair or head skin cosmetics composite
Technical field
The present invention relates to a kind of compositions improving hair or scalp state, especially will be selected from i) pyridine Thioketone zinc;Ii) pantothenylol;And iii) salicylic acid, nicotiamide and more than one things of Cacumen Platycladi core extract Matter is as effective ingredient, thus obtains having Anti-hair loss and the hair of promotion hair growth effect or scalp Cosmetic compositions.
Background technology
In the today increasingly pursuing beauty, depilation phenomenon becomes a big problem of beauty treatment fields.Cause de- The reason sent out has heredity, androgen, aging, pressure, malnutrition and other causes for pathological etc..Its In, the depilation phenomenon caused by the depilation phenomenon being caused androgen or genetic cause, in medical science side Face has conducted in-depth research, and in terms for the treatment of, has already been developed to suppression and has participated in male The medicine of the 5-alpha-reductase that hormone dihydrotestosterone generates, the most representational is to have obtained U.S. FDA Finasteride (Finasteride, the Prppecia of accreditation;MSD).It addition, pressure and undernutrition etc. Reason can cause peripheral blood disorder, thus reduces the function of the hair follicle of synthesis hair, thus causes alopecia, Therefore, develop by promoting that peripheral blood circulation strengthens the Anti-hair loss medicine of hair follicle function, Qi Zhongyi The topical minoxidil obtaining U.S. FDA accreditation is to expand blood vessel by open calcium channel, thus has There is Anti-hair loss effect.The hair follicle being in resting stage can be guided to trophophase it addition, minoxidil also has And continue to trophophase activity effect (British Journal of Dermatology., 2004;150: 186-194).Such as a lot of Anti-hair loss medicines such as minoxidils, although have a significant effect clinically, But its mechanism of action can not be specified.Ebrean Registered Patent publication the 10-0839588th discloses containing Chinese herbaceous peony The Anti-hair loss of the extract of the plants such as medicine, Cacumen Platycladi core, Radix Polygoni Multiflori and green tea and trichogenous combination Thing, and Korean Patent Laid the 2007-0065950th discloses containing water-soluble (vitamin) B race And pyridine oxide with by expanding hair follicle blood flow and trichogenous compositions.
It addition, recently in addition to demand in terms of promoting hair growth, there is also by daily management with The demand of Anti-hair loss, these demands continue to increase in women and youngster, and in order to cater to such need Ask, every day use by cleaning for the purpose of shampoo composite in add Anti-hair loss effective ingredient in case Alopecia has become a kind of trend.Ebrean Registered Patent publication the 10-0581316th discloses containing Herba Leonuri Grass, Nardostachys chinensis Batal., Flos Chrysanthemi, Semen Persicae, Fructus Corni, Semen Cuscutae, Fructus Schisandrae Chinensis, the Rhizoma Atractylodis Macrocephalae, Folium Pini and Radix Angelicae Sinensis etc. The Anti-hair loss of Chinese herbal medicine hybrid extraction liquid and promotion hair growth stimulant compositions;Ebrean Registered Patent publication The Hair-loss-preventingshampoo shampoo group that No. 10-0609210 discloses containing angelica root and the ethanolic extract of Radix Arctii Compound, by utilizing the cupreol of angelica root suppress 5-alpha-reductase and utilize the inulin of Radix Arctii Composition improves blood flow, thus has Anti-hair loss effect;Ebrean Registered Patent publication the 10-0579710th Disclose the ginkalide A (ginkgolide A) from Folium Ginkgo extraction by containing, ginkalide B And bilobalide (bilobalide) thus there is anti-dandruff simultaneously and generate and the shampoo group of Anti-hair loss effect Compound;Ebrean Registered Patent publication the 10-0763437th discloses containing the total soap of Radix Ginseng Rubra, Radix Glycyrrhizae, dimension There is Anti-hair loss and promote that hair growth is made of raw element H, copper peptide and the nanometer liposome containing cytokine Head skin cosmetics composite;Ebrean Registered Patent publication the 10-0806125th discloses by inciting somebody to action In the gold silver water dissolve Jin Heyin, put into various natural Chinese medicinal herb and boil the extract mixing of extraction extremely In shampoo composite, thus obtain the manufacture method with the shampoo of Anti-hair loss and effect of defending the doctrine.
Summary of the invention
Therefore, the present inventor develops energetically and gets final product letter as shampoo in daily management Anti-hair loss just it is provided and promotes the compositions of hair growth effect, thus completing the present invention.The present invention is led to Crossing will be selected from i) Zinc Pyrithione;Ii) pantothenylol;And iii) salicylic acid, nicotiamide and Cacumen Platycladi core extraction More than one materials of thing, can be with the hair week of longer time maintenance trophophase as compositions useful Phase, thus there is Anti-hair loss and promote hair growth effect.
Therefore, it is an object of the invention to provide a kind of hair or head skin cosmetics composite, these cosmetics Compositions by promote to from resting stage to the guiding in anagen hair cycle and maintain growth for a long time The hair cycle of phase, thus there is Anti-hair loss and promote hair growth effect.
The object of the present invention is achieved like this: provides and has Anti-hair loss and promote the hair of hair growth effect Sending out or head skin cosmetics composite, this cosmetic composition will be selected from i) Zinc Pyrithione;Ii) pantothenylol; And iii) salicylic acid, nicotiamide and Cacumen Platycladi core extract more than one materials as effective ingredient.
The hair of the present invention or head skin cosmetics composite pass through will be selected from i) Zinc Pyrithione;Ii) pantothenylol; And iii) salicylic acid, nicotiamide and Cacumen Platycladi core extract more than one materials as effective ingredient, with Promote guiding to the anagen hair cycle from resting stage and maintaining the hair of trophophase all for a long time Phase, thus reduce the depilation phenomenon of scalp, promote hair growth.
Accompanying drawing explanation
Fig. 1 is to represent the chart that the compositions of the present invention has Anti-hair loss effect;
Fig. 2 is to represent that the compositions of the present invention has the chart promoting white mice hair growth effect.
Detailed description of the invention
The present invention is described in detail further below.
The present invention relates to that there is Anti-hair loss and the hair of promotion hair growth effect or scalp cosmetics combination Thing, this cosmetic composition will be selected from i) Zinc Pyrithione;Ii) pantothenylol;And iii) salicylic acid, cigarette More than one materials of amide and Cacumen Platycladi core extract are as effective ingredient.
Described Zinc Pyrithione (Zinc pyrithione) for the present invention can be conventional use of antibacterial The one of agent, Zinc Pyrithione is the composition of the anti-mycotic efficiency with suppression scurf brood cell bacterium growth, can Represent with following chemical formula 1:
Chemical formula 1:
The anti-dandruff of present commercial type and the alleviation shampoo of scalp itch, hair dye and conditioner, Also have in the major part product such as emulsion or curry and all contain mentioned component.
In the present invention, it act as purpose, described cosmetic composition with Anti-hair loss and promotion hair growth To be advisable containing the Zinc Pyrithione accounting for gross weight 0.01-2.0 weight %.If the content of Zinc Pyrithione is low In 0.01 weight %, then function and poor effect, and if more than 2.0 weight %, then formula is stablized Property can produce impact.
Described pantothenylol for the present invention can be D-panthenol or DL-Panthenol, available following chemical formula 2 Represent:
Chemical formula 2:
Described pantothenylol is the another name of pantothenic acid, refers to absorb to the internal vitamin that can be converted into vitamin afterwards Former B5.Pantothenylol is mainly used as wetting agent, softening agent and wetting agent in cosmetics, is possible to prevent inflammation And pruritus, make hair submissive, improve hair strength.
In the present invention, it act as purpose, described cosmetic composition with Anti-hair loss and promotion hair growth To be advisable containing the pantothenylol accounting for gross weight 0.01-2.0 weight %.If the content of pantothenylol is less than 0.01 weight %, Then function and poor effect, and if more than 2.0 weight %, then the stability of formula can be produced impact.
Salicylic acid for the present invention can represent with following chemical formula 3:
Chemical formula 3:
Salicylic acid is always widely used in the medicine of the various diseases relevant to skin, for pimple, head The treatment of bits, white macula, cutin, verruca vulgaris and clavus etc..It addition, because salicylic acid has antiinflammatory action, Therefore the raw material of aspirin (hexanoyl salicylic acid) as analgesics is also served as.
In the present invention, it act as purpose, described cosmetic composition with Anti-hair loss and promotion hair growth To be advisable containing the salicylic acid accounting for gross weight 0.01-2.0 weight %.If salicylic content is less than 0.01 weight Amount %, then function and poor effect, and if more than 2.0 weight %, then the stability of formula can be produced Impact.
Described nicotiamide for the present invention can represent with following chemical formula 4:
Chemical formula 4:
Nicotiamide refers to vitamin B3, is a kind of water soluble vitamins, plays and protein in human body The effect of the auxiliary enzymes of the enzyme reaction that metabolism is relevant.It addition, because nicotiamide has the effect of expansion blood vessel, So may be used for expanding blood flow of the tip.
In the present invention, it act as purpose, described cosmetic composition with Anti-hair loss and promotion hair growth To be advisable containing the nicotiamide accounting for gross weight 0.01-2.0 weight %.If the content of nicotiamide is less than 0.01 weight Amount %, then function and poor effect, and if more than 2.0 weight %, then the stability of formula can be produced Impact.
Cacumen Platycladi core (Thujae semen) is Cacumen Platycladi (Thuja orientalis (occidentalis) (Cacumen Platycladi section) Curpressaceae) seed, in oval to oblong shape or elongated cylindrical, a length of 3-5mm, A diameter of 2-3mm.Cacumen Platycladi core has effect (outline is learned by Japan) of tranquilizing by nourishing the heart, loosening bowel to relieve constipation, its In containing the fatty oil (fatty oil) of high-load.In a hair piece for Dong-eui-bo-gam, the prescription of three holy cream is Being made up of Radix Aconiti Lateralis Preparata, Fructus Viticis and Cacumen Platycladi core, primary efficacy is vibrissa or the hair regrowth making to come off, Concrete grammar is, takes each 20 grams of Radix Aconiti Lateralis Preparata, Fructus Viticis and Cacumen Platycladi core and pulverizes into powder, puts into Gallus Domesticus fat, dry Dry, after being subsequently placed in porcelain vessel sealing placement 100 days, take out the position being applied in alopecia 3-5 days, the hair (a Dong-eui-bo-gam hair piece " three holy cream " (Nan Shantang)) made new advances can be grown.It addition, Cacumen Platycladi core shows inhibitory activity to 5-alpha-reductase (5-α reductase), and at two kinds of animal moulds In type, show height and educate knitting, therefore, Cacumen Platycladi core can be made for losing hair or feathers by regulation androgen The treatment (Journal of Dermatological Science, 2003,31:91-98) of disease.
Cacumen Platycladi core extract for the present invention, it is possible to use the published method in this area is from the kind of Cacumen Platycladi Son extracts and obtains.Can be, but not limited to profit extract with the following method.Utilize 95% ethanol extraction of 2 times of volumes Take Cacumen Platycladi core, after filtering, concentrating, put into the water of 5 times of volumes and the ethyl acetate vibration of 5 times of volumes, So that layering.After utilizing magnesium sulfate to remove the moisture in ethyl acetate layer, filter, be concentrated to give Cacumen Platycladi Core extract.
In the present invention, it act as purpose, described cosmetic composition with Anti-hair loss and promotion hair growth To be advisable containing the Cacumen Platycladi core extract accounting for gross weight 0.01-2.0 weight %.If containing of Cacumen Platycladi core extract Amount less than 0.01 weight %, then function and poor effect, and if more than 2.0 weight %, then to formula Stability can produce impact.
The hair of the present invention or head skin cosmetics composite, can be used in mixed way the one in above-mentioned effective ingredient Or two or more, especially, when being used in mixed way three kinds of effective above compositions, the most more can improve anticreep Hair and trichogenous effect.
According to one embodiment of present invention, the hair of the present invention or effectively becoming of head skin cosmetics composite Divide and can contain Zinc Pyrithione, pantothenylol and salicylic acid, or containing thioketone zinc, pantothenylol, nicotiamide and side Bai Ren extract.
According to one embodiment of present invention, hair or the head skin cosmetics composite of the present invention can also contain There are the normally used anion surfactant in this area, cationic polymer and modifying ingredients.
Anion surfactant for the present invention can be, but not limited to as alkyl sulfate (Alkyl Sulfate), ethoxylated alkyl sulfates (Ethoxylated alkyl sulfate), alcohol ether carboxylate (Alkyl Ethoxy carboxylate), alkyl glyceryl ether sulfonate (Alkyl glyceryl ether sulfonate), second Oxygen ether sulfonate (Ethoxy ether sulfonate), ethoxy ether sulfate (Methyl acyl Taurate), sulfonylmethyl taurine (Alkyl sulfosuccinate), ethyoxyl alkyl sulfosuccinic (Alkyl ethoxy sulfosuccinate), α-alpha-sulfonated fatty acid, its salt and/or its ester, alkyl phosphoric acid Ester (Alkyl phosphate ester), ethoxylated alkyl phosphate ester (Ethoxylated alkyl phosphate Ester), linear alkylbenzene sulfonate (LAS) (Straight-chain alkyl benzene sulfonate), paraffin sulfonic acid Salt (Paraffin sulfonate), α-alkenes sulfonate (α-olefin sulfonate), alkyl sodium sulfate alcoxyl Base (Alkyl alkoxy sulfate) and mixture thereof.The alkyl of above-mentioned surface activity and/or the chain of acyl group A length of C12-18, preferably C12-14.If the chain length of alkyl and/or acyl group is less than C12, then because of surface activity power The most weak cannot use, and if the chain length of alkyl and/or acyl group is more than C18, then cannot because of less bubble power Use.In the present invention, the content of described anion surfactant accounts for described cosmetic composition gross weight 1-50 weight % of amount, preferably 5-20 weight %.If the content of described anion surfactant is less than 1 Weight %, it is impossible to obtain the cleaning force possessed needed for cleaning agent, and if more than 50 weight %, then can possess Too strong cleaning force and the stimulation to human body.
Cationic polymer for the present invention can be, but not limited to as hydroxyethyl cellulose Polymeric quaternary ammonium salts (the Polymeric quaternary ammonium of (Hydroxyethyl cellulose) Salt) it is and hydroxypropyl guar bean oronain (Guar Hydroxypropyl triammonium chloride) is Deng.Cationic polymer have regulation hair, make hair surface submissive, improve bubble power and increase foam Effect.In the present invention, the content of described cationic polymer accounts for described cosmetic composition gross weight 0.1-1.0 weight %, preferably 0.1-0.5 weight %.If the content of described cationic polymer is less than 0.1 Weight %, does not the most have above-mentioned effect, and if more than 1.0 weight %, then be difficult to control to its viscosity, mistake Degree is attached to hair, thus is substantially reduced use sense.
Modifying ingredients for the present invention can be, but not limited to as Cyclomethicone (Cyclomethicone), simethicone (dimethyl polysiloxane) (Dimethicone (Dimethyl Polysiloxane)), dimethicone copolyol (Dimethicone copolyol), alkyl poly-two Methylsiloxane copolyol (Alkyl dimethicone copolyol), esters of silicon acis (Silicon ester), fluorine Dimethyl siloxane (Fluoro dimethicone), alkyl dimethicone (Alkyl dimethicone), Dimethicone copolyol amine (Dimethicone copolyol amine), carboxylic acid silicon (carboxylic Silicon), silicon phosphate ester (Silicon phosphate ester), silicones (silicone resin), silicon phosphorus Fat (Silicon phospholipid), amino-terminated dimethyl polysiloxane (Amodimethicone), poly- Aminopropyl dimethyl siloxane (Aminopropyl dimethicone) and silicon quaternary ammonium compound (silicone Quats) silicon.In the present invention, the content of described modifying ingredients accounts for described cosmetic composition gross weight 0.01-5.0 weight %, preferably 1.3-3.0 weight %.If the content of described modifying ingredients is less than 0.01 weight Amount %, then cannot obtain regulating effect, and if more than 5.0 weight %, then cause because of the instability of formula The decline of quality.
It addition, according to one embodiment of present invention, maintaining within the scope of stability, hair of the present invention Send out or head skin cosmetics composite can also containing appropriate pigment commonly used in the art, preservative, Metal ion sealant and spice etc..
In one embodiment of the present of invention, hair or head skin cosmetics composite can be hair cleanser Compositions, can be shampoo, hair dye, hair conditioner, hair style inorganic agent, ointment, scalp curing The formula of agent, hair lotion, suppurative mastitis, trichotrophy astringent or general ointment etc..
The following detailed description of about hair or head skin cosmetics composite presently preferred embodiments of the present invention and Comparative example.But, following embodiment is only preferred embodiment of the present invention, and the present invention is not real by these Execute the restriction of example.
Reference example 1
To 1kg be dried Cacumen Platycladi core in add 2L 95% ethanol water, carry out three times backflow Extract and filter, concentrate, be subsequently added into water and each 5L of ethyl acetate, after vibration layering, utilize sulfur Acid magnesium is removed the moisture of ethyl acetate layer and filters, is concentrated to give Cacumen Platycladi core extract.
Embodiment 1-2 and comparative example 1
Mix each composition according to the ratio shown in table 1 below and prepare embodiment 1-2 and the compositions of comparative example 1 (unit: weight %).Pyrithione zinc solution is that food pharmaceuticals State Security Department announces the 48% of specification Zinc Pyrithione dispersion liquid (API CORPORATION (2-3-4, NIHONBASHT, CHUO-KU, TOKYO, 103-0027, JAPAN)) directly it is scattered in embodiment 1-2 and comparative example The formula of 1 uses, and pantothenylol is by U.S. pharmacopoeia specification (DSM Nutritional Products LTD. water and surfactant (Darly Ayrshire Scotland UK KA25JJ)) it are dissolved at normal temperatures Mixed liquor uses.It addition, salicylic acid is by Pharmacopoeia Coreana specification (Rhodia Organique (Rue Gaston Monmousseau 38556 Roussillon, France)) raw material the technique of heating of 65 DEG C In be dissolved in the mixed liquor of water and surfactant use.Nicotiamide is by British Pharmacopoeia specification (Amsal Chem.Pvt.Ltd. (A-1/401/402/403, G.I.D.C., Ankleshwar, Gujarat State, India.)) It is dissolved at normal temperatures in the mixed liquor of water and surfactant and using, and side prepared in reference example 1 Bai Ren extract be by pharmacopeia outside independent specification ((strain) Korea Spro Buddhist agriculture (coltfoal city, Long Ren city of Gyeonggi 505-1 in city is upper and lower)) it is added directly in formula use.
Table 1
Composition Comparative example 1 Embodiment 1 Embodiment 2
Purify water Surplus Surplus Surplus
Pyrithione zinc solution 0.5 0.4 0.3
Pantothenylol 0.5 0.4 0.3
Salicylic acid - 0.2 -
Nicotiamide - - 0.2
Cacumen Platycladi core extract (reference example 1) - - 0.2
Ammonium lauryl sulfate solution 30 30 30
Ten diester ammonium sulfates 20 20 20
Dodecyl dimethylamine oxide solution 5 5 5
Benzoic acid formicester 0.1 0.1 0.1
Cortex cocois radicis vinegar amine MEA 1.0 1.0 1.0
Spermol 0.5 0.5 0.5
Polyquaternary ammonium salt 10 0.5 0.5 0.5
Spice 1.0 1.0 1.0
Test example 1
With 30 experimenters with initial stage depilation phenomenon for object carried out 16 weeks by a definite date about anticreep The test of outbreak.Experimenter uses above-described embodiment 1-2 and the compositions of comparative example 1, once-a-day, After totally 16 weeks, collecting alopecia when wash my hair and count, its result is as shown in table 2 and Fig. 1.
Table 2
Process group Average (the individual)/standard deviation of alopecia quantity
Comparative example 1 81.20/10.10
Embodiment 1 74.87/8.71
Embodiment 2 73.50/7.55
Knowable to the result of above-mentioned table 2 and Fig. 1, compared with the compositions of comparative example 1, utilize the present invention The result of the compositions-treated of embodiment 1-2, the quantity of experimenter's alopecia significantly reduces.
Test example 2
Hair growth effect is promoted for test, right for test with the white mice (C57BL/6) being born 7 weeks As, after scraping off the hair at back, for each group of material select skin of back preferable 10 be only used as testing right As.Above-described embodiment 1-2 of 150 μ L and the compositions of comparative example 1 smear to the individuality often organized by every day The afterwash of totally 21 days.The weight measuring the hair newly grown afterwards in 23 days, compares, and its result is such as Shown in table 3 below and Fig. 2.
Table 3
Process group Hair weight average (mg)/standard deviation
Comparative example 1 44.20/6.44
Embodiment 1 52.00/6.58
Embodiment 2 54.80/8.22
Knowable to the result of above-mentioned table 3 and Fig. 2, compared with the compositions of comparative example 1, the present invention is real Execute the compositions of example 1-2 when the white mice being in resting stage hair cycle, can promote to growth stage hair The change in the cycle of sending out, therefore, the compositions of the present invention has more outstanding trichogenous effect.

Claims (3)

1. it is used for Anti-hair loss or promotes hair or a head skin cosmetics composite, this change of natural on-off cycles of hair growth Cosmetic compositions contains
I) Zinc Pyrithione,
Ii) pantothenylol and
Iii) salicylic acid,
As effective ingredient;
Wherein, the content of described Zinc Pyrithione accounts for the 0.01-2.0 weight of described cosmetic composition gross weight Amount %;
The content of described pantothenylol accounts for 0.01-2.0 weight % of described cosmetic composition gross weight;
Described salicylic content accounts for 0.01-2.0 weight % of described cosmetic composition gross weight.
Cosmetic composition the most according to claim 1, wherein, described Zinc Pyrithione, general Alcohol and salicylic content account for 0.4 weight % of described cosmetic composition gross weight, 0.4 weight respectively Amount % and 0.2 weight %.
Cosmetic composition the most according to claim 1, wherein, described cosmetic composition is Shampoo, hair dye, hair conditioner, hair style inorganic agent, scalp curing agent, hair lotion, suppurative mastitis, hair Nutrition astringent or the formula of ointment.
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US8440237B2 (en) 2009-04-27 2013-05-14 Mary Kay Inc. Botanical anti-acne formulations
CN107961192B (en) 2011-12-19 2021-09-24 玫琳凯有限公司 Application of composition containing red bean extract
KR101510939B1 (en) * 2013-05-16 2015-04-10 제주대학교 산학협력단 Composition containing extracts of wheat bran as an active ingredient for preventing of hair loss or for promoting hair growth
US9937119B2 (en) 2013-10-29 2018-04-10 Mary Kay Inc. Cosmetic compositions
CN105078827B (en) * 2015-08-26 2018-01-12 拉芳家化股份有限公司 A kind of functions of nourishing hair and growing hair liquid containing shrubby sophora extract
WO2017127344A1 (en) 2016-01-20 2017-07-27 The Procter & Gamble Company Hair conditioning composition comprising monoalkyl glyceryl ether
CN106474016A (en) * 2016-12-16 2017-03-08 深圳市聚华太科技有限公司 A kind of scalp topical composition and scalp tonic liquid
CN106619230A (en) * 2017-01-20 2017-05-10 冷梦亮 Camellia seed balanced liquid for repairing hair
WO2019048288A1 (en) * 2017-09-11 2019-03-14 Unilever N.V. An antimicrobial composition

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CN1079142A (en) * 1992-02-17 1993-12-08 野村学 Hair grower
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CN101342127A (en) * 2008-08-25 2009-01-14 许庆华 Concave-convex stick alopecia-proof anti-dandruff shampoo
CN101461762A (en) * 2009-01-13 2009-06-24 徐艳萍 Shampoo composition containing vitamin active additive agent

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CN1079142A (en) * 1992-02-17 1993-12-08 野村学 Hair grower
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CN101342127A (en) * 2008-08-25 2009-01-14 许庆华 Concave-convex stick alopecia-proof anti-dandruff shampoo
CN101461762A (en) * 2009-01-13 2009-06-24 徐艳萍 Shampoo composition containing vitamin active additive agent

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