CN107550749A - A kind of hair growth composition and its application - Google Patents
A kind of hair growth composition and its application Download PDFInfo
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- CN107550749A CN107550749A CN201710956197.XA CN201710956197A CN107550749A CN 107550749 A CN107550749 A CN 107550749A CN 201710956197 A CN201710956197 A CN 201710956197A CN 107550749 A CN107550749 A CN 107550749A
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Abstract
The invention discloses a kind of hair growth composition and its application.Described hair growth composition mainly includes the component of following mass parts：0.1 5 parts of pyrrole alkyl amino pyrimidine oxide, 0.1 5 parts of dimethyl sulfone.Pyrrole alkyl amino pyrimidine oxide therein can promote telogen to the anagen in hair cycle to change, dimethyl sulfone provides the organic sulfur nutrient source of necessary condition for keratin fiber synthesis, free radical can also be removed, suppress inflammation, both share, the multiple effect to stimulate circulation with potassium channels opening, the expression for promoting hair follicle cell to breed, promoting human keratin fiber can be played, realizes good hair-growing effects from inside to outside.
Description
Technical field
The present invention relates to cosmetic field, is specifically related to a kind of hair growth composition and its application.
Background technology
There is ten hundreds of hairs on human tau, general hair monthly grows about 1 centimetre.The growth and replacement of hair are to be in
Periodically.The growth cycle of normal hair can mitogenetic long-term, catagen and stand-down three phases, in growth period, hair from
Hair follicle base portion is grown, and can continuously grow 2-6, until being fully grown-up to;It it is 3 weeks, hair stops during this period followed by catagen
Only grow, root of hair atrophy;It is finally stand-down, lasts about 3 months, epilation.Then a new hair start again growth,
Another growth cycle is repeated, hair is usually in the different phase of growth cycle, comes off and grow in dynamic equilibrium, puts down
The epilation of 100 or so is there are about daily.Coming off with new life for it is the state in relative equilibrium in general.If
Because of various internal other factors, destroy this normal growth cycle or broken this balance, or even destroy the knot of hair follicle
Structure, then trichomadesis is excessive, or can not grow new hair again for a long time, will cause oligotrichosis symptom.
The interior research to hair tonic of industry at present is relatively more, for example Chinese patent ZL2011101053360 discloses a kind of life
Agent is sent out, is made up of the component of following parts by weight：Ginseng 10-50 parts, psoralea corylifolia 10-50 parts, fleece-flower root 10-50 parts, Semen sesami nigrum 10-
50 parts, Radix Angelicae Sinensis 10-50 parts, rhizoma Gastrodiae 10-50 parts, tuber of dwarf lilyturf 10-50 part, cultivated land 10-50 parts, fructus viticis 10-50 parts, root bark of white mulberry 5-40
Part, Eclipta prostrata 5-40 parts, Flos Chrysanthemi 5-40 parts, cacumen biotae 5-40 parts；Declare that anti-aging preparation for baldness treated effect reaches 99%.
Chinese patent ZL2005100202292 discloses a kind of rapid-acting hair promoting liquid, by the fleece-flower root, camphor, official osmanthus, myrobalan, cultivated land, radix glycyrrhizae
And sesame oil, through crushing, soaking and press filtration is formulated, declare total effective rate more than 98%.
However, it is found by the inventors that in product for improving hair-growing disclosed in prior art, complicated component and species is various, between component
Correlation it is indefinite, and mostly use natural plants, it plays the component content of effect and is difficult to control, the matter of products obtained therefrom
Measure it is unstable, in this way, will increase product for improving hair-growing uncertain risk.Based on above-mentioned, there is provided a kind of composition is simple, and mechanism is bright
Really, safe and reliable hair growth composition is very necessary.
The content of the invention
Technical problem to be solved of the embodiment of the present invention is, there is provided a kind of hair growth composition.
Concrete technical scheme is as follows：
In a first aspect, the embodiments of the invention provide a kind of hair growth composition, include the component of following mass parts：Pyrrolidinyl two
Aminopyrimidine oxide 0.1-5 parts, dimethyl sulfone 0.1-5 parts.
In wherein some embodiments, described hair growth composition includes the component of following mass parts：Pyrrolidinyl diamino
Yl pyrimidines oxide 0.5-2 parts, dimethyl sulfone 1-3 parts.
In wherein some embodiments, described hair growth composition also includes the component of following mass parts：Panthenol 0.1-5
Part, niacinamide 0.1-5 parts, adenosine 0.1-1 parts.
Further, preferably, hair growth composition of the present invention also contains the component of following mass parts：Radix glycyrrhizae time
Sour 0.1-1 parts, madecassoside 0.1-1 parts, azelaic acid 0.1-1 parts.
Second aspect, hair growth composition of the present invention can be used as a kind of additive application in hair care product
In, often it is prepared with hair-washing hair-care field with auxiliary material.Specifically, the hair care product can be shampoo, hair conditioner,
Treatment wax, hair film, hair-cream, hair care spraying, hair nutrition liquid.
The third aspect, the embodiment of the present invention additionally provide a kind of hair tonic nutrient solution, include the component of following mass percent：
Deodorization alcohol 1-10%
Butanediol 1-10%
Saualane 1-10%
Caffeine 0.1-2%
PEG-20 methyl sesquistearates 0.1-0.5%
Ammonium acryloyldime-thyltaurate/VP copolymers 0.1-0.5%
Xanthans 0.1-0.5%
Hydroxypropyl cyclodextrin 0.1-0.5%
Menthol 0.1-0.5%
Citric acid 0.1-0.5%
Above-mentioned hair growth composition 0.2-24%
Water surplus.
Compared with prior art, the beneficial effect that technical scheme provided in an embodiment of the present invention is brought is：The present invention is carried
The hair growth composition of confession, formed through effective ratio science compounding, pyrrole alkyl amino pyrimidine oxide therein can promote hair
Telogen to the anagen transformation in life cycle is sent out, dimethyl sulfone provides necessary bar for keratin fiber synthesis
The organic sulfur nutrient source of part, moreover it is possible to remove free radical, suppress inflammation, both share, and can play stimulating circulation and potassium channel
The multiple effect of the expression of human keratin fiber is bred, promoted to open, promotion hair follicle cell, realizes good hair tonic from inside to outside
Effect.The addition of panthenol, niacinamide, adenosine, enoxolone, madecassoside, azelaic acid, supplement scalp nutrition can be played,
The effect to enhance metabolism, there is obvious facilitation to the hair-growing effects of composition.
Embodiment
To make the object, technical solutions and advantages of the present invention clearer, embodiment of the present invention will be made into one below
Step ground is described in detail, but the implementation of the present invention is not limited to this, for especially not dated technological parameter or condition, can refer to
Routine techniques is carried out.
Pyrrole alkyl amino pyrimidine oxide of the present invention, entitled 6- pyrrolidinyls -2, the 4- Diaminopyrimidines of chemistry
Pyridine -3- oxides, its structural formula are：
。
Dimethyl sulfone of the present invention, the very important organic sulfur source of life entity.The basic function of organic sulfur includes dimension
The composition of people's vivo protein is held, keratin necessary to forming the growth of hair and nail is helped and maintains exempting from for immune system
The generation of epidemic disease globulin, while to food conversion is played into catalytic action for the chemical reaction of energy.Dimethyl sulfone is that glutathione resists
The source of oxygen agent sulphur, glutathione are most important antioxidants in human body, are risen emphatically to eliminating oxygen radical caused by human body
Act on, improve the immunoregulation effect of skin.Dimethyl sulfone also has anti-inflammatory and antioxidation, can alleviate skin to environment
Allergy, remove the free radicals such as hydrogen peroxide, superoxides.The molecular formula of dimethyl sulfone is C2H6O2S, structural formula are：
。
Panthenol of the present invention, it is the precursor of vitamin B5, the metabolism of human body protein, fat, carbohydrate can be promoted,
The growth of epithelial cell is stimulated, promotes wound healing, prevents hair jag, is damaged, increases the density of hair, improves the light of hair quality
Pool.
Niacinamide of the present invention, participate in oxidation-reduction reaction, intervene the physiology courses such as energetic supersession, remaining thin
Played a significant role in the normal activities of born of the same parents；Pharmacological action with DNA reparations, anti-aging etc..
Adenosine of the present invention, refer to the change being formed by connecting by the N-9 of adenine and the C-1 of D-ribose by β glycosidic bonds
Compound.Adenosine is a kind of endogenous nucleoside for spreading all over human body cell, and adenylate can be converted into human body, participates in energetic supersession,
Expansion coronary artery blood vessel is also participated in simultaneously, increases CBF.Many other systems and tissue of the adenosine to cardiovascular system and human body
There is physiological action.
Enoxolone of the present invention, there is removing toxic substances, anti-inflammatory, analgesia, antineoplastic action.Enoxolone is to big white mouse
Granuloma induced by implantation of cotton pellets and swollen, the subcutaneous granuloma inflammation of formaldehyde pin etc. have inhibitory action, its anti-inflammatory potency is about cortisone
Or hydrogenation can pine 1/10.Rat Experimental arthritis has inhibitory action caused by enoxolone Carrageenan, to horse serum
Or cavy allergic reaction has different degrees of inhibitory action caused by Egg-white.Its anti-inflammatory, antianaphylaxis may be with suppression
Capillary permeability, antihistamine reduce cell to the reactive relevant of stimulation.
Madecassoside of the present invention, from centella.Madecassoside can suppress collagenous fibres, have
Suppress the effect of proliferation of fibrous tissue, promote skin growth, the stable effect of calmness.
Azelaic acid of the present invention, molecular formula are HOOC (CH2) 7-COOH, are slightly soluble in water.Research shows that azelaic acid has
Have and suppress the aerobic bacterias such as gold staphylococcus, MRSE, pseudomonas aeruginosa, Candida albicans, propionibacterium acnes
With the effect of anaerobic bacteria, (it is more than 250mmolL-1) in higher concentration, there is killing action to above-mentioned bacterium；In addition, can
The enzyme process of Reverse transcriptase dihydrotestosterone, the skin oil and fat that reduction dihydrotestosterone factor induces is excessive, reduces skin surface trip
From aliphatic acid and the composition of lipid；Also anti-keratinous effect, its action principle mainly due to the synthesis for reducing thread keratin, from
And reduce follicular hyperkeratosis.
Embodiment 1
A kind of hair tonic nutrient solution, include the component of following mass percent：
Deodorization alcohol 1%
Butanediol 10%
Saualane 1%
Dimethyl sulfone 5%
Pyrrole alkyl amino pyrimidine oxide 0.1%
Caffeine 2%
PEG-20 methyls sesquistearate 0.1%
Ammonium acryloyldime-thyltaurate/VP copolymers 0.5%
Xanthans 0.1%
Hydroxypropyl cyclodextrin 0.5%
Menthol 0.1%
Citric acid 0.5%
Water surplus.
Embodiment 2
A kind of hair tonic nutrient solution, include the component of following mass percent：
Deodorization alcohol 10%
Butanediol 1%
Saualane 10%
Dimethyl sulfone 0.1%
Pyrrole alkyl amino pyrimidine oxide 5%
Caffeine 0.1%
PEG-20 methyls sesquistearate 0.5%
Ammonium acryloyldime-thyltaurate/VP copolymers 0.1%
Xanthans 0.5%
Hydroxypropyl cyclodextrin 0.1%
Menthol 0.5%
Citric acid 0.1%
Water surplus.
Embodiment 3
A kind of hair tonic nutrient solution, include the component of following mass percent：
Deodorization alcohol 5%
Butanediol 5%
Saualane 5%
Dimethyl sulfone 1%
Pyrrole alkyl amino pyrimidine oxide 2%
Caffeine 1%
PEG-20 methyls sesquistearate 0.25%
Ammonium acryloyldime-thyltaurate/VP copolymers 0.25%
Xanthans 0.25%
Hydroxypropyl cyclodextrin 0.25%
Menthol 0.25%
Citric acid 0.25%
Water surplus.
Embodiment 4
A kind of hair tonic nutrient solution, include the component of following mass percent：
Deodorization alcohol 5%
Butanediol 5%
Saualane 5%
Dimethyl sulfone 3%
Pyrrole alkyl amino pyrimidine oxide 0.5%
Caffeine 1%
PEG-20 methyls sesquistearate 0.25%
Ammonium acryloyldime-thyltaurate/VP copolymers 0.25%
Xanthans 0.25%
Hydroxypropyl cyclodextrin 0.25%
Menthol 0.25%
Citric acid 0.25%
Water surplus.
Embodiment 5
A kind of hair tonic nutrient solution, include the component of following mass percent：
Deodorization alcohol 5%
Butanediol 5%
Saualane 5%
Dimethyl sulfone 2%
Pyrrole alkyl amino pyrimidine oxide 1%
Caffeine 1%
PEG-20 methyls sesquistearate 0.25%
Ammonium acryloyldime-thyltaurate/VP copolymers 0.25%
Xanthans 0.25%
Hydroxypropyl cyclodextrin 0.25%
Menthol 0.25%
Citric acid 0.25%
Panthenol 0.1%
Niacinamide 5%
Adenosine 0.1%
Water surplus.
Embodiment 6
A kind of hair tonic nutrient solution, include the component of following mass percent：
Deodorization alcohol 5%
Butanediol 5%
Saualane 5%
Dimethyl sulfone 2%
Pyrrole alkyl amino pyrimidine oxide 1%
Caffeine 1%
PEG-20 methyls sesquistearate 0.25%
Ammonium acryloyldime-thyltaurate/VP copolymers 0.25%
Xanthans 0.25%
Hydroxypropyl cyclodextrin 0.25%
Menthol 0.25%
Citric acid 0.25%
Panthenol 5%
Niacinamide 0.1%
Adenosine 1%
Water surplus.
Embodiment 7
A kind of hair tonic nutrient solution, include the component of following mass percent：
Deodorization alcohol 5%
Butanediol 5%
Saualane 5%
Dimethyl sulfone 2%
Pyrrole alkyl amino pyrimidine oxide 1%
Caffeine 1%
PEG-20 methyls sesquistearate 0.25%
Ammonium acryloyldime-thyltaurate/VP copolymers 0.25%
Xanthans 0.25%
Hydroxypropyl cyclodextrin 0.25%
Menthol 0.25%
Citric acid 0.25%
Panthenol 5%
Niacinamide 0.1%
Adenosine 1%
Enoxolone 0.1%
Madecassoside 1%
Azelaic acid 0.1%
Water surplus.
Embodiment 8
A kind of hair tonic nutrient solution, include the component of following mass percent：
Deodorization alcohol 5%
Butanediol 5%
Saualane 5%
Dimethyl sulfone 2%
Pyrrole alkyl amino pyrimidine oxide 1%
Caffeine 1%
PEG-20 methyls sesquistearate 0.25%
Ammonium acryloyldime-thyltaurate/VP copolymers 0.25%
Xanthans 0.25%
Hydroxypropyl cyclodextrin 0.25%
Menthol 0.25%
Citric acid 0.25%
Panthenol 5%
Niacinamide 0.1%
Adenosine 1%
Enoxolone 1%
Madecassoside 0.1%
Azelaic acid 1%
Water surplus.
The preparation method of hair growth liquor described in embodiment 1-8 is as follows：
（1）Water is put into emulsification pot, then puts into hydroxypropyl cyclodextrin, is dispersed with stirring uniformly；
（2）Advance butanediol, xanthans are well mixed, and in input emulsification pot, are stirred；Then caffeine, propylene are added
Acyl dimethyltaurine ammonium/VP copolymers, stirs, and is heated to 85 DEG C；
（3）By saualane, PEG-20 methyls sesquistearate, menthol input oil phase pot, 80 DEG C are heated to, stirring
Dissolving；
（4）Oil phase is pumped into emulsification pot under stirring, opens 3000rpm homogeneous 5 minutes, vacuumizing and defoaming, is incubated 20 minutes, so
After cool to 48 DEG C；
（5）By deodorization alcohol, citric acid, above-mentioned hair growth composition input emulsification pot, stir, you can.
Comparative example 1
The difference of comparative example 1 and embodiment 4 is：Comparative example 1 is not comprising dimethyl sulfone.
Comparative example 2
The difference of comparative example 2 and embodiment 4 is：Comparative example 2 is not comprising pyrrole alkyl amino pyrimidine oxide.
Comparative example 3
The difference of comparative example 3 and embodiment 6 is：Comparative example 3 is not comprising panthenol.
Comparative example 4
The difference of comparative example 4 and embodiment 6 is：Comparative example 4 is not comprising adenosine.
Comparative example 5
The difference of comparative example 5 and embodiment 8 is：Comparative example 5 is not comprising azelaic acid.
Comparative example 6
The difference of comparative example 6 and embodiment 8 is：Comparative example 6 is not comprising enoxolone.
Embodiment 8
To obtained by embodiment 1-8 and comparative example 1-7/the hair tonic nutrient solution with hair tonic effect bought carries out effect test and appraisal
（Comparative example 7 is a commercially available hair growth liquor for declaring to have hair tonic effect）.
Specific method of testing is as follows：Each experimental group chooses 10 volunteers, age 40-60 year, exiguous human hair be present
Symptom；Application method：It is dry to seventy percent to clean hair post processing, takes appropriate hair tonic nutrient solution rubbing hair root, then gently press
Rub 3-5 minutes, combed with horn comb, each 1 time sooner or later, continuous on probation 12 weeks, mug, and trier is returned
Visit.Evaluation method：The 0th day and the 12nd week photo are contrasted, wherein hair is obvious dense to be effective；What hair was increased slightly is to have
Effect；Exiguous human hair phenomenon do not have to change to be invalid.Specific test result such as table 1.All paid a return visit on probation after on probation 12 weeks,
Without there is allergic phenomenon, show that the hair tonic nutrient solution is safe and non-toxic.
The test result record sheet of table 1
| It is effective | Effectively | It is invalid | |
| Embodiment 1 | 3 | 4 | 3 |
| Embodiment 2 | 3 | 3 | 4 |
| Embodiment 3 | 4 | 4 | 2 |
| Embodiment 4 | 5 | 3 | 2 |
| Embodiment 5 | 6 | 3 | 1 |
| Embodiment 6 | 7 | 2 | 1 |
| Embodiment 7 | 9 | 0 | 1 |
| Embodiment 8 | 8 | 2 | 0 |
| Comparative example 1 | 0 | 1 | 9 |
| Comparative example 2 | 0 | 2 | 8 |
| Comparative example 3 | 3 | 4 | 3 |
| Comparative example 4 | 4 | 3 | 3 |
| Comparative example 5 | 6 | 3 | 1 |
| Comparative example 6 | 5 | 3 | 2 |
| Comparative example 7 | 1 | 3 | 6 |
From the result of table 1：
Embodiment 1-4 and comparative example 1-2,7 contrasts are visible, and the hair tonic nutrient solution significant effect obtained by the present invention is better than contrast
Example.
Embodiment 5-6 and embodiment 3-4, comparative example 3-4 contrast are visible, and panthenol, niacinamide, gland are added in hair tonic nutrient solution
Hair-growing effects are obviously improved after glycosides, and just have synergistic effect during above-mentioned 3 kinds of raw materials compounding.
Embodiment 7-8 and embodiment 5-6, comparative example 5-6 contrast are visible, and enoxolone, hydroxyl are added in hair tonic nutrient solution
Hair-growing effects are further improved after Asiaticoside, azelaic acid, and just have synergistic effect during above-mentioned 3 kinds of raw materials compounding.
The above described is only a preferred embodiment of the present invention, any formal limitation not is done to the present invention, therefore
All contents without departing from technical solution of the present invention, the technical spirit according to the present invention any are simply repaiied to made for any of the above embodiments
Change, equivalent variations and modification, in the range of still falling within technical solution of the present invention.
Claims (7)
1. a kind of hair growth composition, it is characterised in that include the component of following mass parts：Pyrrole alkyl amino pyrimidine oxide
0.1-5 parts, dimethyl sulfone 0.1-5 parts.
2. hair growth composition according to claim 1, it is characterised in that described hair growth composition includes following mass parts
Component：Pyrrole alkyl amino pyrimidine oxide 0.5-2 parts, dimethyl sulfone 1-3 parts.
3. hair growth composition according to claim 1 or 2, it is characterised in that described hair growth composition also includes following
The component of mass parts：Panthenol 0.1-5 parts, niacinamide 0.1-5 parts, adenosine 0.1-1 parts.
4. hair growth composition according to claim 1 or 2, it is characterised in that hair growth composition of the present invention also contains
There is the component of following mass parts：Enoxolone 0.1-1 parts, madecassoside 0.1-1 parts, azelaic acid 0.1-1 parts.
5. a kind of hair care product with hair tonic effect, it is characterised in that the hair care product is by claim 1-4
Hair growth composition and hair-washing hair-care field described in any one are often prepared with auxiliary material.
6. hair growth composition according to claim 5, it is characterised in that the hair care product is shampoo, hair care
Su, treatment waxes, hair film, hair-cream, hair care spraying, hair nutrition liquid.
7. a kind of hair tonic nutrient solution, it is characterised in that include the component of following mass percent：
Deodorization alcohol 1-10%
Butanediol 1-10%
Saualane 1-10%
Caffeine 0.1-2%
PEG-20 methyl sesquistearates 0.1-0.5%
Ammonium acryloyldime-thyltaurate/VP copolymers 0.1-0.5%
Xanthans 0.1-0.5%
Hydroxypropyl cyclodextrin 0.1-0.5%
Menthol 0.1-0.5%
Citric acid 0.1-0.5%
Hair growth composition 0.2-24% described in claim any one of 1-4
Water surplus.
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